-- dump date   	20140619_111801
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
65093000001	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
65093000002	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
65093000003	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
65093000004	trimer interface [polypeptide binding]; other site
65093000005	putative metal binding site [ion binding]; other site
65093000006	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
65093000007	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
65093000008	oligomer interface [polypeptide binding]; other site
65093000009	metal binding site [ion binding]; metal-binding site
65093000010	metal binding site [ion binding]; metal-binding site
65093000011	Cl binding site [ion binding]; other site
65093000012	aspartate ring; other site
65093000013	basic sphincter; other site
65093000014	putative hydrophobic gate; other site
65093000015	periplasmic entrance; other site
65093000016	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
65093000017	DnaA N-terminal domain; Region: DnaA_N; pfam11638
65093000018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093000019	Walker A motif; other site
65093000020	ATP binding site [chemical binding]; other site
65093000021	Walker B motif; other site
65093000022	arginine finger; other site
65093000023	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
65093000024	DnaA box-binding interface [nucleotide binding]; other site
65093000025	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093000026	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
65093000027	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
65093000028	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
65093000029	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65093000030	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
65093000031	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
65093000032	MutS domain I; Region: MutS_I; pfam01624
65093000033	MutS domain II; Region: MutS_II; pfam05188
65093000034	MutS domain III; Region: MutS_III; pfam05192
65093000035	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
65093000036	Walker A/P-loop; other site
65093000037	ATP binding site [chemical binding]; other site
65093000038	Q-loop/lid; other site
65093000039	ABC transporter signature motif; other site
65093000040	Walker B; other site
65093000041	D-loop; other site
65093000042	H-loop/switch region; other site
65093000043	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
65093000044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093000045	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65093000046	Coenzyme A binding pocket [chemical binding]; other site
65093000047	methionine sulfoxide reductase A; Provisional; Region: PRK13014
65093000048	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
65093000049	Radical SAM superfamily; Region: Radical_SAM; pfam04055
65093000050	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
65093000051	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
65093000052	DNA binding residues [nucleotide binding]
65093000053	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
65093000054	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
65093000055	CHAT domain; Region: CHAT; cl17868
65093000056	NACHT domain; Region: NACHT; pfam05729
65093000057	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
65093000058	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65093000059	metal ion-dependent adhesion site (MIDAS); other site
65093000060	Protein phosphatase 2C; Region: PP2C_2; pfam13672
65093000061	active site
65093000062	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093000063	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65093000064	active site
65093000065	ATP binding site [chemical binding]; other site
65093000066	substrate binding site [chemical binding]; other site
65093000067	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65093000068	substrate binding site [chemical binding]; other site
65093000069	activation loop (A-loop); other site
65093000070	activation loop (A-loop); other site
65093000071	Part of AAA domain; Region: AAA_19; pfam13245
65093000072	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
65093000073	AAA domain; Region: AAA_12; pfam13087
65093000074	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
65093000075	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
65093000076	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
65093000077	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
65093000078	Predicted transcriptional regulators [Transcription]; Region: COG1725
65093000079	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
65093000080	DNA-binding site [nucleotide binding]; DNA binding site
65093000081	PsaD; Region: PsaD; pfam02531
65093000082	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
65093000083	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
65093000084	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
65093000085	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
65093000086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093000087	S-adenosylmethionine binding site [chemical binding]; other site
65093000088	ribosomal protein L21; Region: rpl21; CHL00075
65093000089	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
65093000090	PBP superfamily domain; Region: PBP_like_2; cl17296
65093000091	hydrolase, alpha/beta fold family protein; Region: PLN02824
65093000092	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093000093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093000094	active site
65093000095	phosphorylation site [posttranslational modification]
65093000096	intermolecular recognition site; other site
65093000097	dimerization interface [polypeptide binding]; other site
65093000098	GAF domain; Region: GAF; cl17456
65093000099	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093000100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093000101	putative active site [active]
65093000102	heme pocket [chemical binding]; other site
65093000103	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65093000104	Histidine kinase; Region: HisKA_2; pfam07568
65093000105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093000106	ATP binding site [chemical binding]; other site
65093000107	Mg2+ binding site [ion binding]; other site
65093000108	G-X-G motif; other site
65093000109	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
65093000110	Dehydroquinase class II; Region: DHquinase_II; pfam01220
65093000111	trimer interface [polypeptide binding]; other site
65093000112	active site
65093000113	dimer interface [polypeptide binding]; other site
65093000114	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
65093000115	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
65093000116	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65093000117	Zn2+ binding site [ion binding]; other site
65093000118	Mg2+ binding site [ion binding]; other site
65093000119	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65093000120	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093000121	catalytic residues [active]
65093000122	Conserved TM helix; Region: TM_helix; pfam05552
65093000123	Conserved TM helix; Region: TM_helix; pfam05552
65093000124	Conserved TM helix; Region: TM_helix; pfam05552
65093000125	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
65093000126	hydrophobic ligand binding site; other site
65093000127	Uncharacterized conserved protein [Function unknown]; Region: COG2912
65093000128	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
65093000129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000130	TPR motif; other site
65093000131	binding surface
65093000132	recombination protein RecR; Reviewed; Region: recR; PRK00076
65093000133	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
65093000134	RecR protein; Region: RecR; pfam02132
65093000135	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
65093000136	putative active site [active]
65093000137	putative metal-binding site [ion binding]; other site
65093000138	tetramer interface [polypeptide binding]; other site
65093000139	Predicted permease [General function prediction only]; Region: COG3329
65093000140	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65093000141	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
65093000142	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093000143	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65093000144	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093000145	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65093000146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093000147	Probable transposase; Region: OrfB_IS605; pfam01385
65093000148	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093000149	Bacterial Ig-like domain; Region: Big_5; pfam13205
65093000150	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093000151	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093000152	Methyltransferase domain; Region: Methyltransf_25; pfam13649
65093000153	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
65093000154	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65093000155	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65093000156	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65093000157	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
65093000158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093000159	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65093000160	NAD(P) binding site [chemical binding]; other site
65093000161	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
65093000162	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65093000163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093000164	active site
65093000165	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
65093000166	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
65093000167	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
65093000168	putative active site [active]
65093000169	putative metal binding site [ion binding]; other site
65093000170	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
65093000171	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093000172	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
65093000173	Integral membrane protein TerC family; Region: TerC; cl10468
65093000174	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65093000175	EamA-like transporter family; Region: EamA; cl17759
65093000176	EamA-like transporter family; Region: EamA; cl17759
65093000177	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
65093000178	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
65093000179	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65093000180	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65093000181	NAD(P) binding site [chemical binding]; other site
65093000182	putative active site [active]
65093000183	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
65093000184	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093000185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093000186	active site
65093000187	phosphorylation site [posttranslational modification]
65093000188	intermolecular recognition site; other site
65093000189	dimerization interface [polypeptide binding]; other site
65093000190	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093000191	DNA binding site [nucleotide binding]
65093000192	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
65093000193	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093000194	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
65093000195	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
65093000196	active site
65093000197	catalytic site [active]
65093000198	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
65093000199	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093000200	putative ADP-binding pocket [chemical binding]; other site
65093000201	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093000202	Probable transposase; Region: OrfB_IS605; pfam01385
65093000203	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093000204	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65093000205	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65093000206	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65093000207	ketol-acid reductoisomerase; Provisional; Region: PRK05479
65093000208	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
65093000209	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
65093000210	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093000211	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
65093000212	cofactor binding site; other site
65093000213	DNA binding site [nucleotide binding]
65093000214	substrate interaction site [chemical binding]; other site
65093000215	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093000216	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093000217	active site
65093000218	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
65093000219	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
65093000220	active site
65093000221	homotetramer interface [polypeptide binding]; other site
65093000222	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
65093000223	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
65093000224	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
65093000225	Ligand Binding Site [chemical binding]; other site
65093000226	Molecular Tunnel; other site
65093000227	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
65093000228	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
65093000229	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
65093000230	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65093000231	catalytic residue [active]
65093000232	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093000233	putative active site [active]
65093000234	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
65093000235	active site
65093000236	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
65093000237	Ligand Binding Site [chemical binding]; other site
65093000238	Molecular Tunnel; other site
65093000239	E3 Ubiquitin ligase; Region: GIDE; pfam12483
65093000240	flavoprotein, HI0933 family; Region: TIGR00275
65093000241	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
65093000242	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
65093000243	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
65093000244	trimer interface [polypeptide binding]; other site
65093000245	active site
65093000246	UDP-GlcNAc binding site [chemical binding]; other site
65093000247	lipid binding site [chemical binding]; lipid-binding site
65093000248	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
65093000249	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
65093000250	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093000251	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
65093000252	putative homodimer interface [polypeptide binding]; other site
65093000253	putative homotetramer interface [polypeptide binding]; other site
65093000254	putative metal binding site [ion binding]; other site
65093000255	putative homodimer-homodimer interface [polypeptide binding]; other site
65093000256	putative allosteric switch controlling residues; other site
65093000257	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
65093000258	NifU-like domain; Region: NifU; pfam01106
65093000259	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
65093000260	Peptidase family M50; Region: Peptidase_M50; pfam02163
65093000261	active site
65093000262	putative substrate binding region [chemical binding]; other site
65093000263	ribonuclease Z; Region: RNase_Z; TIGR02651
65093000264	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
65093000265	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
65093000266	FMN binding site [chemical binding]; other site
65093000267	substrate binding site [chemical binding]; other site
65093000268	putative catalytic residue [active]
65093000269	magnesium chelatase subunit H; Provisional; Region: PLN03241
65093000270	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093000271	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093000272	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
65093000273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65093000274	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
65093000275	metal ion-dependent adhesion site (MIDAS); other site
65093000276	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
65093000277	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
65093000278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093000279	Mg2+ binding site [ion binding]; other site
65093000280	G-X-G motif; other site
65093000281	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
65093000282	anchoring element; other site
65093000283	dimer interface [polypeptide binding]; other site
65093000284	ATP binding site [chemical binding]; other site
65093000285	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093000286	protein-splicing catalytic site; other site
65093000287	thioester formation/cholesterol transfer; other site
65093000288	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
65093000289	active site
65093000290	putative metal-binding site [ion binding]; other site
65093000291	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
65093000292	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
65093000293	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
65093000294	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
65093000295	active site
65093000296	dimerization interface [polypeptide binding]; other site
65093000297	Probable transposase; Region: OrfB_IS605; pfam01385
65093000298	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093000299	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093000300	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
65093000301	Nitrogen regulatory protein P-II; Region: P-II; smart00938
65093000302	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
65093000303	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
65093000304	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
65093000305	Secretin and TonB N terminus short domain; Region: STN; pfam07660
65093000306	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
65093000307	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
65093000308	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
65093000309	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
65093000310	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
65093000311	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
65093000312	oligomerization interface [polypeptide binding]; other site
65093000313	active site
65093000314	metal binding site [ion binding]; metal-binding site
65093000315	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093000316	Ligand Binding Site [chemical binding]; other site
65093000317	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
65093000318	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
65093000319	GTP/Mg2+ binding site [chemical binding]; other site
65093000320	G4 box; other site
65093000321	G5 box; other site
65093000322	G1 box; other site
65093000323	Switch I region; other site
65093000324	G2 box; other site
65093000325	G3 box; other site
65093000326	Switch II region; other site
65093000327	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
65093000328	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65093000329	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
65093000330	dimer interface [polypeptide binding]; other site
65093000331	decamer (pentamer of dimers) interface [polypeptide binding]; other site
65093000332	catalytic triad [active]
65093000333	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65093000334	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
65093000335	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
65093000336	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
65093000337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65093000338	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
65093000339	OstA-like protein; Region: OstA; pfam03968
65093000340	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
65093000341	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
65093000342	Walker A/P-loop; other site
65093000343	ATP binding site [chemical binding]; other site
65093000344	Q-loop/lid; other site
65093000345	ABC transporter signature motif; other site
65093000346	Walker B; other site
65093000347	D-loop; other site
65093000348	H-loop/switch region; other site
65093000349	CP12 domain; Region: CP12; pfam02672
65093000350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093000351	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65093000352	active site
65093000353	catalytic tetrad [active]
65093000354	AMIN domain; Region: AMIN; pfam11741
65093000355	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093000356	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093000357	phosphopeptide binding site; other site
65093000358	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093000359	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
65093000360	cyclase homology domain; Region: CHD; cd07302
65093000361	nucleotidyl binding site; other site
65093000362	metal binding site [ion binding]; metal-binding site
65093000363	dimer interface [polypeptide binding]; other site
65093000364	alpha-mannosidase; Provisional; Region: PRK09819
65093000365	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
65093000366	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
65093000367	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
65093000368	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
65093000369	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
65093000370	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
65093000371	dimerization interface [polypeptide binding]; other site
65093000372	putative ATP binding site [chemical binding]; other site
65093000373	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
65093000374	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
65093000375	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
65093000376	Pantoate-beta-alanine ligase; Region: PanC; cd00560
65093000377	active site
65093000378	ATP-binding site [chemical binding]; other site
65093000379	pantoate-binding site; other site
65093000380	HXXH motif; other site
65093000381	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
65093000382	CMP-binding site; other site
65093000383	The sites determining sugar specificity; other site
65093000384	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
65093000385	active site
65093000386	catalytic triad [active]
65093000387	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
65093000388	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
65093000389	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
65093000390	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
65093000391	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
65093000392	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65093000393	AMIN domain; Region: AMIN; pfam11741
65093000394	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
65093000395	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
65093000396	N-terminal plug; other site
65093000397	ligand-binding site [chemical binding]; other site
65093000398	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
65093000399	muropeptide transporter; Validated; Region: ampG; cl17669
65093000400	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
65093000401	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
65093000402	FAD binding domain; Region: FAD_binding_4; pfam01565
65093000403	Berberine and berberine like; Region: BBE; pfam08031
65093000404	AMIN domain; Region: AMIN; pfam11741
65093000405	phycobillisome linker protein; Region: apcE; CHL00091
65093000406	Phycobilisome protein; Region: Phycobilisome; cl08227
65093000407	Phycobilisome protein; Region: Phycobilisome; cl08227
65093000408	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093000409	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093000410	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093000411	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093000412	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
65093000413	Sporulation related domain; Region: SPOR; cl10051
65093000414	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
65093000415	active site
65093000416	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65093000417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000418	binding surface
65093000419	TPR motif; other site
65093000420	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
65093000421	methionine sulfoxide reductase A; Provisional; Region: PRK00058
65093000422	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
65093000423	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
65093000424	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
65093000425	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
65093000426	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
65093000427	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
65093000428	active site
65093000429	zinc binding site [ion binding]; other site
65093000430	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
65093000431	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
65093000432	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
65093000433	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
65093000434	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093000435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093000436	Walker A/P-loop; other site
65093000437	ATP binding site [chemical binding]; other site
65093000438	Q-loop/lid; other site
65093000439	ABC transporter signature motif; other site
65093000440	Walker B; other site
65093000441	D-loop; other site
65093000442	H-loop/switch region; other site
65093000443	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
65093000444	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
65093000445	putative active site [active]
65093000446	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093000447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093000448	Walker A/P-loop; other site
65093000449	ATP binding site [chemical binding]; other site
65093000450	Q-loop/lid; other site
65093000451	ABC transporter signature motif; other site
65093000452	Walker B; other site
65093000453	D-loop; other site
65093000454	H-loop/switch region; other site
65093000455	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
65093000456	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093000457	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093000458	ligand binding site [chemical binding]; other site
65093000459	flexible hinge region; other site
65093000460	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
65093000461	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
65093000462	Domain of unknown function (DUF814); Region: DUF814; pfam05670
65093000463	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093000464	active site
65093000465	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
65093000466	Predicted transcriptional regulator [Transcription]; Region: COG1959
65093000467	Transcriptional regulator; Region: Rrf2; cl17282
65093000468	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
65093000469	RNA polymerase sigma factor; Validated; Region: PRK05949
65093000470	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65093000471	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093000472	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65093000473	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093000474	DNA binding residues [nucleotide binding]
65093000475	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093000476	HSP70 interaction site [polypeptide binding]; other site
65093000477	TPR repeat; Region: TPR_11; pfam13414
65093000478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000479	binding surface
65093000480	TPR motif; other site
65093000481	TPR repeat; Region: TPR_11; pfam13414
65093000482	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
65093000483	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65093000484	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65093000485	active site
65093000486	ATP binding site [chemical binding]; other site
65093000487	substrate binding site [chemical binding]; other site
65093000488	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
65093000489	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
65093000490	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
65093000491	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
65093000492	Mg++ binding site [ion binding]; other site
65093000493	putative catalytic motif [active]
65093000494	putative substrate binding site [chemical binding]; other site
65093000495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093000496	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093000497	putative substrate translocation pore; other site
65093000498	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
65093000499	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
65093000500	C-terminal domain interface [polypeptide binding]; other site
65093000501	active site
65093000502	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
65093000503	active site
65093000504	N-terminal domain interface [polypeptide binding]; other site
65093000505	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093000506	reverse gyrase; Provisional; Region: PRK14701
65093000507	cytochrome c biogenesis protein; Region: ccsA; CHL00045
65093000508	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
65093000509	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
65093000510	Ligand Binding Site [chemical binding]; other site
65093000511	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
65093000512	Response regulator receiver domain; Region: Response_reg; pfam00072
65093000513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093000514	active site
65093000515	phosphorylation site [posttranslational modification]
65093000516	intermolecular recognition site; other site
65093000517	dimerization interface [polypeptide binding]; other site
65093000518	Response regulator receiver domain; Region: Response_reg; pfam00072
65093000519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093000520	active site
65093000521	phosphorylation site [posttranslational modification]
65093000522	intermolecular recognition site; other site
65093000523	dimerization interface [polypeptide binding]; other site
65093000524	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65093000525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000526	binding surface
65093000527	TPR repeat; Region: TPR_11; pfam13414
65093000528	TPR motif; other site
65093000529	HAMP domain; Region: HAMP; pfam00672
65093000530	dimerization interface [polypeptide binding]; other site
65093000531	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093000532	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093000533	dimer interface [polypeptide binding]; other site
65093000534	putative CheW interface [polypeptide binding]; other site
65093000535	Permease; Region: Permease; cl00510
65093000536	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
65093000537	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
65093000538	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
65093000539	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
65093000540	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65093000541	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
65093000542	putative NAD(P) binding site [chemical binding]; other site
65093000543	active site
65093000544	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
65093000545	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
65093000546	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093000547	active site
65093000548	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
65093000549	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
65093000550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000551	binding surface
65093000552	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093000553	TPR motif; other site
65093000554	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65093000555	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
65093000556	HD domain; Region: HD_4; pfam13328
65093000557	CpeS-like protein; Region: CpeS; pfam09367
65093000558	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
65093000559	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
65093000560	Walker A/P-loop; other site
65093000561	ATP binding site [chemical binding]; other site
65093000562	Q-loop/lid; other site
65093000563	ABC transporter signature motif; other site
65093000564	Walker B; other site
65093000565	D-loop; other site
65093000566	H-loop/switch region; other site
65093000567	Protein kinase domain; Region: Pkinase; pfam00069
65093000568	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093000569	active site
65093000570	ATP binding site [chemical binding]; other site
65093000571	substrate binding site [chemical binding]; other site
65093000572	activation loop (A-loop); other site
65093000573	TPR repeat; Region: TPR_11; pfam13414
65093000574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000575	binding surface
65093000576	TPR motif; other site
65093000577	TPR repeat; Region: TPR_11; pfam13414
65093000578	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000579	binding surface
65093000580	TPR motif; other site
65093000581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000582	binding surface
65093000583	TPR repeat; Region: TPR_11; pfam13414
65093000584	TPR motif; other site
65093000585	TPR repeat; Region: TPR_11; pfam13414
65093000586	S-layer homology domain; Region: SLH; pfam00395
65093000587	S-layer homology domain; Region: SLH; pfam00395
65093000588	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093000589	putative active site [active]
65093000590	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093000591	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65093000592	Walker A/P-loop; other site
65093000593	ATP binding site [chemical binding]; other site
65093000594	Q-loop/lid; other site
65093000595	ABC transporter signature motif; other site
65093000596	Walker B; other site
65093000597	D-loop; other site
65093000598	H-loop/switch region; other site
65093000599	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
65093000600	OstA-like protein; Region: OstA; cl00844
65093000601	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
65093000602	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
65093000603	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
65093000604	putative dimer interface [polypeptide binding]; other site
65093000605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093000606	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65093000607	NAD(P) binding site [chemical binding]; other site
65093000608	active site
65093000609	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
65093000610	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
65093000611	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093000612	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65093000613	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
65093000614	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093000615	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
65093000616	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65093000617	TM2 domain; Region: TM2; cl00984
65093000618	Short C-terminal domain; Region: SHOCT; pfam09851
65093000619	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
65093000620	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
65093000621	hypothetical protein; Reviewed; Region: PRK09588
65093000622	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
65093000623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093000624	active site
65093000625	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093000626	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093000627	H+ Antiporter protein; Region: 2A0121; TIGR00900
65093000628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093000629	putative substrate translocation pore; other site
65093000630	Recombination protein O N terminal; Region: RecO_N; pfam11967
65093000631	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
65093000632	Recombination protein O C terminal; Region: RecO_C; pfam02565
65093000633	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
65093000634	intersubunit interface [polypeptide binding]; other site
65093000635	active site
65093000636	catalytic residue [active]
65093000637	FOG: CBS domain [General function prediction only]; Region: COG0517
65093000638	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
65093000639	CP12 domain; Region: CP12; pfam02672
65093000640	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
65093000641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
65093000642	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
65093000643	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
65093000644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093000645	S-adenosylmethionine binding site [chemical binding]; other site
65093000646	Protein of unknown function (DUF972); Region: DUF972; pfam06156
65093000647	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
65093000648	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
65093000649	tetramerization interface [polypeptide binding]; other site
65093000650	active site
65093000651	XisI protein; Region: XisI; pfam08869
65093000652	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
65093000653	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
65093000654	RuvA N terminal domain; Region: RuvA_N; pfam01330
65093000655	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
65093000656	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
65093000657	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
65093000658	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
65093000659	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65093000660	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093000661	catalytic residues [active]
65093000662	FtsH Extracellular; Region: FtsH_ext; pfam06480
65093000663	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
65093000664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093000665	Walker A motif; other site
65093000666	ATP binding site [chemical binding]; other site
65093000667	Walker B motif; other site
65093000668	arginine finger; other site
65093000669	Peptidase family M41; Region: Peptidase_M41; pfam01434
65093000670	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
65093000671	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
65093000672	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
65093000673	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093000674	protein-splicing catalytic site; other site
65093000675	thioester formation/cholesterol transfer; other site
65093000676	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
65093000677	Homing endonuclease; Region: Hom_end; pfam05204
65093000678	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
65093000679	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
65093000680	active site
65093000681	Cytochrome c; Region: Cytochrom_C; cl11414
65093000682	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65093000683	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65093000684	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65093000685	B12 binding site [chemical binding]; other site
65093000686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093000687	FeS/SAM binding site; other site
65093000688	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
65093000689	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093000690	catalytic core [active]
65093000691	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093000692	catalytic core [active]
65093000693	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093000694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093000695	S-adenosylmethionine binding site [chemical binding]; other site
65093000696	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
65093000697	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
65093000698	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
65093000699	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
65093000700	active site
65093000701	metal binding site [ion binding]; metal-binding site
65093000702	DNA binding site [nucleotide binding]
65093000703	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
65093000704	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
65093000705	Active Sites [active]
65093000706	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
65093000707	putative active site [active]
65093000708	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
65093000709	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65093000710	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65093000711	active site
65093000712	catalytic site [active]
65093000713	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
65093000714	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
65093000715	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
65093000716	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093000717	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65093000718	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65093000719	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093000720	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093000721	ligand binding site [chemical binding]; other site
65093000722	flexible hinge region; other site
65093000723	S-layer homology domain; Region: SLH; pfam00395
65093000724	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
65093000725	YacP-like NYN domain; Region: NYN_YacP; pfam05991
65093000726	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
65093000727	Rhomboid family; Region: Rhomboid; pfam01694
65093000728	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
65093000729	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65093000730	Catalytic site [active]
65093000731	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65093000732	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
65093000733	tellurite resistance protein terB; Region: terB; cd07176
65093000734	putative metal binding site [ion binding]; other site
65093000735	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
65093000736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093000737	FeS/SAM binding site; other site
65093000738	HemN C-terminal domain; Region: HemN_C; pfam06969
65093000739	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
65093000740	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
65093000741	putative active site [active]
65093000742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
65093000743	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
65093000744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093000745	S-adenosylmethionine binding site [chemical binding]; other site
65093000746	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
65093000747	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
65093000748	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
65093000749	triosephosphate isomerase; Provisional; Region: PRK14565
65093000750	dimer interface [polypeptide binding]; other site
65093000751	substrate binding site [chemical binding]; other site
65093000752	catalytic triad [active]
65093000753	Uncharacterized conserved protein [Function unknown]; Region: COG1543
65093000754	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
65093000755	active site
65093000756	substrate binding site [chemical binding]; other site
65093000757	catalytic site [active]
65093000758	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
65093000759	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65093000760	nudix motif; other site
65093000761	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
65093000762	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
65093000763	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
65093000764	HicB family; Region: HicB; pfam05534
65093000765	PIN domain; Region: PIN_3; pfam13470
65093000766	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
65093000767	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
65093000768	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
65093000769	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
65093000770	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093000771	putative active site [active]
65093000772	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093000773	putative active site [active]
65093000774	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
65093000775	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
65093000776	active site
65093000777	PAS domain; Region: PAS_9; pfam13426
65093000778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093000779	putative active site [active]
65093000780	heme pocket [chemical binding]; other site
65093000781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093000782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093000783	metal binding site [ion binding]; metal-binding site
65093000784	active site
65093000785	I-site; other site
65093000786	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093000787	dephospho-CoA kinase; Region: TIGR00152
65093000788	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
65093000789	CoA-binding site [chemical binding]; other site
65093000790	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
65093000791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093000792	Walker A motif; other site
65093000793	ATP binding site [chemical binding]; other site
65093000794	Walker B motif; other site
65093000795	arginine finger; other site
65093000796	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
65093000797	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
65093000798	metal ion-dependent adhesion site (MIDAS); other site
65093000799	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
65093000800	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65093000801	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093000802	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65093000803	HicB family; Region: HicB; pfam05534
65093000804	Ycf46; Provisional; Region: ycf46; CHL00195
65093000805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093000806	Walker A motif; other site
65093000807	ATP binding site [chemical binding]; other site
65093000808	Walker B motif; other site
65093000809	arginine finger; other site
65093000810	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
65093000811	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
65093000812	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
65093000813	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
65093000814	hypothetical protein; Validated; Region: PRK00029
65093000815	Uncharacterized conserved protein [Function unknown]; Region: COG0397
65093000816	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
65093000817	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65093000818	Walker A/P-loop; other site
65093000819	ATP binding site [chemical binding]; other site
65093000820	Q-loop/lid; other site
65093000821	ABC transporter signature motif; other site
65093000822	Walker B; other site
65093000823	D-loop; other site
65093000824	H-loop/switch region; other site
65093000825	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65093000826	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65093000827	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65093000828	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
65093000829	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
65093000830	motif 1; other site
65093000831	active site
65093000832	motif 2; other site
65093000833	motif 3; other site
65093000834	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
65093000835	RRXRR protein; Region: RRXRR; pfam14239
65093000836	Staphylococcal nuclease homologues; Region: SNc; smart00318
65093000837	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
65093000838	Catalytic site; other site
65093000839	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
65093000840	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
65093000841	putative catalytic residues [active]
65093000842	TPR repeat; Region: TPR_11; pfam13414
65093000843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093000844	binding surface
65093000845	TPR motif; other site
65093000846	TPR repeat; Region: TPR_11; pfam13414
65093000847	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
65093000848	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
65093000849	putative active site [active]
65093000850	substrate binding site [chemical binding]; other site
65093000851	putative cosubstrate binding site; other site
65093000852	catalytic site [active]
65093000853	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
65093000854	substrate binding site [chemical binding]; other site
65093000855	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093000856	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65093000857	Hexamer interface [polypeptide binding]; other site
65093000858	Hexagonal pore residue; other site
65093000859	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093000860	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
65093000861	Hexamer interface [polypeptide binding]; other site
65093000862	Hexagonal pore residue; other site
65093000863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
65093000864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093000865	non-specific DNA binding site [nucleotide binding]; other site
65093000866	salt bridge; other site
65093000867	sequence-specific DNA binding site [nucleotide binding]; other site
65093000868	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
65093000869	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65093000870	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
65093000871	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
65093000872	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093000873	Ligand Binding Site [chemical binding]; other site
65093000874	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093000875	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093000876	active site
65093000877	ATP binding site [chemical binding]; other site
65093000878	substrate binding site [chemical binding]; other site
65093000879	activation loop (A-loop); other site
65093000880	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
65093000881	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
65093000882	tartrate dehydrogenase; Region: TTC; TIGR02089
65093000883	Exocyst complex subunit Sec15-like; Region: Sec15; pfam04091
65093000884	Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785
65093000885	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
65093000886	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
65093000887	hydrolase, alpha/beta fold family protein; Region: PLN02824
65093000888	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093000889	Tannase and feruloyl esterase; Region: Tannase; pfam07519
65093000890	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
65093000891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093000892	Walker A/P-loop; other site
65093000893	ATP binding site [chemical binding]; other site
65093000894	Q-loop/lid; other site
65093000895	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65093000896	ABC transporter signature motif; other site
65093000897	Walker B; other site
65093000898	D-loop; other site
65093000899	ABC transporter; Region: ABC_tran_2; pfam12848
65093000900	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65093000901	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65093000902	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
65093000903	Precorrin-8X methylmutase; Region: CbiC; pfam02570
65093000904	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65093000905	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093000906	active site
65093000907	ATP binding site [chemical binding]; other site
65093000908	substrate binding site [chemical binding]; other site
65093000909	activation loop (A-loop); other site
65093000910	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
65093000911	GIY-YIG motif/motif A; other site
65093000912	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65093000913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093000914	Coenzyme A binding pocket [chemical binding]; other site
65093000915	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
65093000916	Ca2+ binding site [ion binding]; other site
65093000917	VCBS repeat; Region: VCBS_repeat; TIGR01965
65093000918	Uncharacterized conserved protein [Function unknown]; Region: COG4095
65093000919	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
65093000920	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
65093000921	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
65093000922	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
65093000923	active site
65093000924	catalytic residues [active]
65093000925	DNA polymerase III subunit delta'; Validated; Region: PRK07399
65093000926	AAA ATPase domain; Region: AAA_16; pfam13191
65093000927	DNA polymerase III subunit delta'; Validated; Region: PRK08485
65093000928	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
65093000929	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
65093000930	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
65093000931	NADP binding site [chemical binding]; other site
65093000932	active site
65093000933	putative substrate binding site [chemical binding]; other site
65093000934	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
65093000935	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
65093000936	substrate binding site; other site
65093000937	metal-binding site
65093000938	Oligomer interface; other site
65093000939	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65093000940	pantothenate kinase; Reviewed; Region: PRK13331
65093000941	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
65093000942	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
65093000943	NAD(P) binding site [chemical binding]; other site
65093000944	homotetramer interface [polypeptide binding]; other site
65093000945	homodimer interface [polypeptide binding]; other site
65093000946	active site
65093000947	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
65093000948	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
65093000949	hinge; other site
65093000950	active site
65093000951	amidase; Provisional; Region: PRK09201
65093000952	Amidase; Region: Amidase; cl11426
65093000953	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
65093000954	ligand binding site [chemical binding]; other site
65093000955	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
65093000956	active site
65093000957	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65093000958	YGGT family; Region: YGGT; pfam02325
65093000959	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65093000960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
65093000961	Predicted kinase [General function prediction only]; Region: COG0645
65093000962	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
65093000963	ATP-binding site [chemical binding]; other site
65093000964	Gluconate-6-phosphate binding site [chemical binding]; other site
65093000965	PBP superfamily domain; Region: PBP_like_2; cl17296
65093000966	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
65093000967	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65093000968	substrate binding site [chemical binding]; other site
65093000969	ATP binding site [chemical binding]; other site
65093000970	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093000971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093000972	active site
65093000973	phosphorylation site [posttranslational modification]
65093000974	intermolecular recognition site; other site
65093000975	dimerization interface [polypeptide binding]; other site
65093000976	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093000977	DNA binding site [nucleotide binding]
65093000978	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
65093000979	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65093000980	Membrane protein of unknown function; Region: DUF360; pfam04020
65093000981	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65093000982	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65093000983	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65093000984	protein binding site [polypeptide binding]; other site
65093000985	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
65093000986	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
65093000987	substrate-cofactor binding pocket; other site
65093000988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093000989	catalytic residue [active]
65093000990	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
65093000991	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
65093000992	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
65093000993	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
65093000994	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
65093000995	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
65093000996	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
65093000997	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
65093000998	active site
65093000999	SAM binding site [chemical binding]; other site
65093001000	homodimer interface [polypeptide binding]; other site
65093001001	Domain of unknown function DUF39; Region: DUF39; pfam01837
65093001002	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
65093001003	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
65093001004	DNA binding site [nucleotide binding]
65093001005	catalytic residue [active]
65093001006	H2TH interface [polypeptide binding]; other site
65093001007	putative catalytic residues [active]
65093001008	turnover-facilitating residue; other site
65093001009	intercalation triad [nucleotide binding]; other site
65093001010	8OG recognition residue [nucleotide binding]; other site
65093001011	putative reading head residues; other site
65093001012	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
65093001013	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
65093001014	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585
65093001015	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
65093001016	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093001017	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093001018	ligand binding site [chemical binding]; other site
65093001019	flexible hinge region; other site
65093001020	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65093001021	putative switch regulator; other site
65093001022	non-specific DNA interactions [nucleotide binding]; other site
65093001023	DNA binding site [nucleotide binding]
65093001024	sequence specific DNA binding site [nucleotide binding]; other site
65093001025	putative cAMP binding site [chemical binding]; other site
65093001026	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
65093001027	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
65093001028	TM-ABC transporter signature motif; other site
65093001029	Cupin domain; Region: Cupin_2; cl17218
65093001030	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
65093001031	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65093001032	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093001033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093001034	S-adenosylmethionine binding site [chemical binding]; other site
65093001035	Predicted helicase [General function prediction only]; Region: COG4889
65093001036	N-ATPase, AtpR subunit; Region: AtpR; cl11871
65093001037	ATP synthase CF0 A subunit; Region: atpI; CHL00046
65093001038	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
65093001039	ATP synthase CF0 C subunit; Region: atpH; CHL00061
65093001040	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
65093001041	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
65093001042	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
65093001043	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
65093001044	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
65093001045	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
65093001046	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
65093001047	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65093001048	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
65093001049	beta subunit interaction interface [polypeptide binding]; other site
65093001050	Walker A motif; other site
65093001051	ATP binding site [chemical binding]; other site
65093001052	Walker B motif; other site
65093001053	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65093001054	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
65093001055	core domain interface [polypeptide binding]; other site
65093001056	delta subunit interface [polypeptide binding]; other site
65093001057	epsilon subunit interface [polypeptide binding]; other site
65093001058	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093001059	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093001060	active site
65093001061	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
65093001062	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
65093001063	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
65093001064	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
65093001065	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
65093001066	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093001067	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
65093001068	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093001069	recombinase A; Provisional; Region: recA; PRK09354
65093001070	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
65093001071	hexamer interface [polypeptide binding]; other site
65093001072	Walker A motif; other site
65093001073	ATP binding site [chemical binding]; other site
65093001074	Walker B motif; other site
65093001075	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
65093001076	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
65093001077	putative tRNA-binding site [nucleotide binding]; other site
65093001078	B3/4 domain; Region: B3_4; pfam03483
65093001079	tRNA synthetase B5 domain; Region: B5; cl08394
65093001080	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
65093001081	dimer interface [polypeptide binding]; other site
65093001082	motif 1; other site
65093001083	motif 3; other site
65093001084	motif 2; other site
65093001085	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
65093001086	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65093001087	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093001088	active site
65093001089	ATP binding site [chemical binding]; other site
65093001090	substrate binding site [chemical binding]; other site
65093001091	activation loop (A-loop); other site
65093001092	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
65093001093	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093001094	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093001095	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093001096	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093001097	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093001098	catalytic core [active]
65093001099	RRXRR protein; Region: RRXRR; pfam14239
65093001100	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093001101	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093001102	active site
65093001103	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
65093001104	DHH family; Region: DHH; pfam01368
65093001105	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093001106	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093001107	active site
65093001108	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
65093001109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093001110	S-adenosylmethionine binding site [chemical binding]; other site
65093001111	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093001112	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65093001113	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
65093001114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093001115	motif II; other site
65093001116	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
65093001117	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
65093001118	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
65093001119	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
65093001120	nucleotide binding pocket [chemical binding]; other site
65093001121	K-X-D-G motif; other site
65093001122	catalytic site [active]
65093001123	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
65093001124	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
65093001125	Helix-hairpin-helix motif; Region: HHH; pfam00633
65093001126	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
65093001127	Dimer interface [polypeptide binding]; other site
65093001128	BRCT sequence motif; other site
65093001129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001130	binding surface
65093001131	TPR motif; other site
65093001132	TPR repeat; Region: TPR_11; pfam13414
65093001133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001134	binding surface
65093001135	TPR motif; other site
65093001136	TPR repeat; Region: TPR_11; pfam13414
65093001137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001138	binding surface
65093001139	TPR motif; other site
65093001140	TPR repeat; Region: TPR_11; pfam13414
65093001141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001142	binding surface
65093001143	TPR motif; other site
65093001144	TPR repeat; Region: TPR_11; pfam13414
65093001145	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65093001146	tetramer interface [polypeptide binding]; other site
65093001147	dimer interface [polypeptide binding]; other site
65093001148	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
65093001149	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
65093001150	Walker A motif; other site
65093001151	ATP binding site [chemical binding]; other site
65093001152	Walker B motif; other site
65093001153	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
65093001154	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
65093001155	putative NAD(P) binding site [chemical binding]; other site
65093001156	active site
65093001157	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
65093001158	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
65093001159	active site residue [active]
65093001160	Phosphoglycerate kinase; Region: PGK; pfam00162
65093001161	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
65093001162	substrate binding site [chemical binding]; other site
65093001163	hinge regions; other site
65093001164	ADP binding site [chemical binding]; other site
65093001165	catalytic site [active]
65093001166	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093001167	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093001168	ligand binding site [chemical binding]; other site
65093001169	flexible hinge region; other site
65093001170	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
65093001171	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
65093001172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
65093001173	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
65093001174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
65093001175	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
65093001176	4-alpha-glucanotransferase; Provisional; Region: PRK14508
65093001177	TrkA-N domain; Region: TrkA_N; pfam02254
65093001178	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
65093001179	TrkA-N domain; Region: TrkA_N; pfam02254
65093001180	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65093001181	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
65093001182	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
65093001183	Helix-turn-helix domain; Region: HTH_37; pfam13744
65093001184	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093001185	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093001186	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65093001187	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65093001188	ribonuclease III; Reviewed; Region: rnc; PRK00102
65093001189	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
65093001190	dimerization interface [polypeptide binding]; other site
65093001191	active site
65093001192	metal binding site [ion binding]; metal-binding site
65093001193	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
65093001194	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
65093001195	Domain of unknown function DUF21; Region: DUF21; pfam01595
65093001196	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65093001197	Transporter associated domain; Region: CorC_HlyC; smart01091
65093001198	Response regulator receiver domain; Region: Response_reg; pfam00072
65093001199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001200	active site
65093001201	phosphorylation site [posttranslational modification]
65093001202	intermolecular recognition site; other site
65093001203	dimerization interface [polypeptide binding]; other site
65093001204	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093001205	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001206	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001207	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001208	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001209	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001210	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001211	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001212	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001213	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001214	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001215	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001216	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001217	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
65093001218	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093001219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093001220	dimer interface [polypeptide binding]; other site
65093001221	putative CheW interface [polypeptide binding]; other site
65093001222	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
65093001223	four helix bundle protein; Region: TIGR02436
65093001224	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093001225	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093001226	putative binding surface; other site
65093001227	active site
65093001228	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093001229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093001230	ATP binding site [chemical binding]; other site
65093001231	Mg2+ binding site [ion binding]; other site
65093001232	G-X-G motif; other site
65093001233	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093001234	Response regulator receiver domain; Region: Response_reg; pfam00072
65093001235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001236	active site
65093001237	phosphorylation site [posttranslational modification]
65093001238	intermolecular recognition site; other site
65093001239	dimerization interface [polypeptide binding]; other site
65093001240	CheW-like domain; Region: CheW; pfam01584
65093001241	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
65093001242	rRNA interaction site [nucleotide binding]; other site
65093001243	S8 interaction site; other site
65093001244	putative laminin-1 binding site; other site
65093001245	elongation factor Ts; Reviewed; Region: tsf; PRK12332
65093001246	UBA/TS-N domain; Region: UBA; pfam00627
65093001247	Elongation factor TS; Region: EF_TS; pfam00889
65093001248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001249	putative active site [active]
65093001250	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
65093001251	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
65093001252	ssDNA binding site; other site
65093001253	generic binding surface II; other site
65093001254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093001255	ATP binding site [chemical binding]; other site
65093001256	putative Mg++ binding site [ion binding]; other site
65093001257	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093001258	nucleotide binding region [chemical binding]; other site
65093001259	ATP-binding site [chemical binding]; other site
65093001260	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
65093001261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093001262	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
65093001263	catalytic center binding site [active]
65093001264	ATP binding site [chemical binding]; other site
65093001265	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
65093001266	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
65093001267	dimer interface [polypeptide binding]; other site
65093001268	ADP-ribose binding site [chemical binding]; other site
65093001269	active site
65093001270	nudix motif; other site
65093001271	metal binding site [ion binding]; metal-binding site
65093001272	Gas vesicle protein G; Region: GvpG; pfam05120
65093001273	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
65093001274	Gas vesicle protein K; Region: GvpK; pfam05121
65093001275	Gas vesicle protein; Region: Gas_vesicle; pfam00741
65093001276	Gas vesicle protein; Region: Gas_vesicle; pfam00741
65093001277	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
65093001278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093001279	Walker A motif; other site
65093001280	ATP binding site [chemical binding]; other site
65093001281	Walker B motif; other site
65093001282	Gas vesicle protein; Region: Gas_vesicle; cl02954
65093001283	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
65093001284	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
65093001285	glucokinase, proteobacterial type; Region: glk; TIGR00749
65093001286	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
65093001287	nucleotide binding site [chemical binding]; other site
65093001288	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093001289	catalytic core [active]
65093001290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001291	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
65093001292	active site
65093001293	phosphorylation site [posttranslational modification]
65093001294	intermolecular recognition site; other site
65093001295	dimerization interface [polypeptide binding]; other site
65093001296	GAF domain; Region: GAF; pfam01590
65093001297	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093001298	metal binding site [ion binding]; metal-binding site
65093001299	active site
65093001300	I-site; other site
65093001301	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
65093001302	PhoH-like protein; Region: PhoH; pfam02562
65093001303	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
65093001304	KH domain; Region: KH_4; pfam13083
65093001305	ribosomal protein S16; Region: rps16; CHL00005
65093001306	dihydrodipicolinate reductase; Provisional; Region: PRK00048
65093001307	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
65093001308	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
65093001309	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
65093001310	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
65093001311	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
65093001312	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
65093001313	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
65093001314	multifunctional aminopeptidase A; Provisional; Region: PRK00913
65093001315	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
65093001316	interface (dimer of trimers) [polypeptide binding]; other site
65093001317	Substrate-binding/catalytic site; other site
65093001318	Zn-binding sites [ion binding]; other site
65093001319	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
65093001320	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
65093001321	NAD binding site [chemical binding]; other site
65093001322	dimer interface [polypeptide binding]; other site
65093001323	substrate binding site [chemical binding]; other site
65093001324	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65093001325	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65093001326	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093001327	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093001328	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65093001329	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001330	putative active site [active]
65093001331	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001332	putative active site [active]
65093001333	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
65093001334	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65093001335	DnaJ domain; Region: DnaJ; pfam00226
65093001336	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
65093001337	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
65093001338	dimerization interface [polypeptide binding]; other site
65093001339	domain crossover interface; other site
65093001340	redox-dependent activation switch; other site
65093001341	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
65093001342	putative active site [active]
65093001343	substrate binding site [chemical binding]; other site
65093001344	redox center [active]
65093001345	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
65093001346	phosphate binding site [ion binding]; other site
65093001347	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
65093001348	acyl carrier protein; Provisional; Region: acpP; PRK00982
65093001349	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
65093001350	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
65093001351	dimer interface [polypeptide binding]; other site
65093001352	active site
65093001353	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
65093001354	transketolase; Region: PLN02790
65093001355	TPP-binding site [chemical binding]; other site
65093001356	dimer interface [polypeptide binding]; other site
65093001357	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
65093001358	PYR/PP interface [polypeptide binding]; other site
65093001359	dimer interface [polypeptide binding]; other site
65093001360	TPP binding site [chemical binding]; other site
65093001361	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65093001362	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
65093001363	catalytic triad [active]
65093001364	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
65093001365	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
65093001366	putative metal binding residues [ion binding]; other site
65093001367	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
65093001368	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
65093001369	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
65093001370	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65093001371	ABC-ATPase subunit  interface; other site
65093001372	dimer interface [polypeptide binding]; other site
65093001373	putative PBP binding regions; other site
65093001374	phosphoribulokinase; Provisional; Region: PRK07429
65093001375	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
65093001376	active site
65093001377	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
65093001378	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
65093001379	putative catalytic cysteine [active]
65093001380	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
65093001381	putative active site [active]
65093001382	metal binding site [ion binding]; metal-binding site
65093001383	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
65093001384	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093001385	FeS/SAM binding site; other site
65093001386	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
65093001387	Pyruvate formate lyase 1; Region: PFL1; cd01678
65093001388	coenzyme A binding site [chemical binding]; other site
65093001389	active site
65093001390	catalytic residues [active]
65093001391	glycine loop; other site
65093001392	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65093001393	catalytic residues [active]
65093001394	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65093001395	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
65093001396	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
65093001397	dimerization interface [polypeptide binding]; other site
65093001398	FAD binding pocket [chemical binding]; other site
65093001399	FAD binding motif [chemical binding]; other site
65093001400	catalytic residues [active]
65093001401	NAD binding pocket [chemical binding]; other site
65093001402	phosphate binding motif [ion binding]; other site
65093001403	beta-alpha-beta structure motif; other site
65093001404	cell division protein; Validated; Region: ftsH; CHL00176
65093001405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093001406	Walker A motif; other site
65093001407	ATP binding site [chemical binding]; other site
65093001408	Walker B motif; other site
65093001409	arginine finger; other site
65093001410	Peptidase family M41; Region: Peptidase_M41; pfam01434
65093001411	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
65093001412	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
65093001413	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
65093001414	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65093001415	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093001416	catalytic residue [active]
65093001417	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
65093001418	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
65093001419	HIGH motif; other site
65093001420	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65093001421	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
65093001422	active site
65093001423	KMSKS motif; other site
65093001424	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
65093001425	tRNA binding surface [nucleotide binding]; other site
65093001426	anticodon binding site; other site
65093001427	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
65093001428	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093001429	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093001430	catalytic loop [active]
65093001431	iron binding site [ion binding]; other site
65093001432	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
65093001433	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
65093001434	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
65093001435	rod shape-determining protein MreB; Provisional; Region: PRK13927
65093001436	MreB and similar proteins; Region: MreB_like; cd10225
65093001437	nucleotide binding site [chemical binding]; other site
65093001438	Mg binding site [ion binding]; other site
65093001439	putative protofilament interaction site [polypeptide binding]; other site
65093001440	RodZ interaction site [polypeptide binding]; other site
65093001441	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
65093001442	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
65093001443	dimer interface [polypeptide binding]; other site
65093001444	ssDNA binding site [nucleotide binding]; other site
65093001445	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65093001446	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
65093001447	FAD binding site [chemical binding]; other site
65093001448	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
65093001449	active site
65093001450	putative lithium-binding site [ion binding]; other site
65093001451	substrate binding site [chemical binding]; other site
65093001452	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093001453	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
65093001454	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65093001455	Catalytic site [active]
65093001456	dihydroorotase; Provisional; Region: PRK07369
65093001457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
65093001458	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
65093001459	active site
65093001460	tellurium resistance terB-like protein; Region: terB_like; cl11965
65093001461	Prolamin-like; Region: Prolamin_like; cl05275
65093001462	cyanate hydratase; Validated; Region: PRK02866
65093001463	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
65093001464	oligomer interface [polypeptide binding]; other site
65093001465	active site
65093001466	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
65093001467	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
65093001468	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65093001469	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65093001470	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
65093001471	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65093001472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65093001473	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65093001474	GTP-binding protein LepA; Provisional; Region: PRK05433
65093001475	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
65093001476	G1 box; other site
65093001477	putative GEF interaction site [polypeptide binding]; other site
65093001478	GTP/Mg2+ binding site [chemical binding]; other site
65093001479	Switch I region; other site
65093001480	G2 box; other site
65093001481	G3 box; other site
65093001482	Switch II region; other site
65093001483	G4 box; other site
65093001484	G5 box; other site
65093001485	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
65093001486	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
65093001487	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
65093001488	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
65093001489	dimerization interface [polypeptide binding]; other site
65093001490	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
65093001491	ATP binding site [chemical binding]; other site
65093001492	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
65093001493	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
65093001494	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
65093001495	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
65093001496	active site
65093001497	ADP/pyrophosphate binding site [chemical binding]; other site
65093001498	dimerization interface [polypeptide binding]; other site
65093001499	allosteric effector site; other site
65093001500	fructose-1,6-bisphosphate binding site; other site
65093001501	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
65093001502	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
65093001503	putative active site [active]
65093001504	putative FMN binding site [chemical binding]; other site
65093001505	putative substrate binding site [chemical binding]; other site
65093001506	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
65093001507	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
65093001508	dimer interface [polypeptide binding]; other site
65093001509	PYR/PP interface [polypeptide binding]; other site
65093001510	TPP binding site [chemical binding]; other site
65093001511	substrate binding site [chemical binding]; other site
65093001512	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65093001513	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
65093001514	Domain of unknown function; Region: EKR; smart00890
65093001515	4Fe-4S binding domain; Region: Fer4_6; pfam12837
65093001516	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
65093001517	TPP-binding site [chemical binding]; other site
65093001518	dimer interface [polypeptide binding]; other site
65093001519	HupF/HypC family; Region: HupF_HypC; pfam01455
65093001520	Acylphosphatase; Region: Acylphosphatase; pfam00708
65093001521	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
65093001522	HypF finger; Region: zf-HYPF; pfam07503
65093001523	HypF finger; Region: zf-HYPF; pfam07503
65093001524	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
65093001525	VCBS repeat; Region: VCBS_repeat; TIGR01965
65093001526	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
65093001527	Ca2+ binding site [ion binding]; other site
65093001528	Uncharacterized conserved protein [Function unknown]; Region: COG5276
65093001529	Bacterial Ig-like domain; Region: Big_5; pfam13205
65093001530	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
65093001531	active site
65093001532	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
65093001533	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
65093001534	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
65093001535	active site
65093001536	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
65093001537	active site
65093001538	pheophorbide a oxygenase; Region: PLN02518
65093001539	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65093001540	iron-sulfur cluster [ion binding]; other site
65093001541	[2Fe-2S] cluster binding site [ion binding]; other site
65093001542	Pheophorbide a oxygenase; Region: PaO; pfam08417
65093001543	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
65093001544	catalytic triad [active]
65093001545	dimer interface [polypeptide binding]; other site
65093001546	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001547	putative active site [active]
65093001548	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
65093001549	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
65093001550	HIGH motif; other site
65093001551	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
65093001552	active site
65093001553	KMSKS motif; other site
65093001554	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
65093001555	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
65093001556	glutamine binding [chemical binding]; other site
65093001557	catalytic triad [active]
65093001558	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
65093001559	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
65093001560	proline aminopeptidase P II; Provisional; Region: PRK10879
65093001561	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
65093001562	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
65093001563	active site
65093001564	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65093001565	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001566	putative active site [active]
65093001567	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093001568	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093001569	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65093001570	Walker A/P-loop; other site
65093001571	ATP binding site [chemical binding]; other site
65093001572	Q-loop/lid; other site
65093001573	ABC transporter signature motif; other site
65093001574	Walker B; other site
65093001575	D-loop; other site
65093001576	H-loop/switch region; other site
65093001577	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65093001578	Cytochrome c; Region: Cytochrom_C; pfam00034
65093001579	shikimate kinase; Reviewed; Region: aroK; PRK00131
65093001580	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
65093001581	ADP binding site [chemical binding]; other site
65093001582	magnesium binding site [ion binding]; other site
65093001583	putative shikimate binding site; other site
65093001584	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
65093001585	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
65093001586	Ferredoxin [Energy production and conversion]; Region: COG1146
65093001587	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093001588	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
65093001589	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
65093001590	Walker A/P-loop; other site
65093001591	ATP binding site [chemical binding]; other site
65093001592	Q-loop/lid; other site
65093001593	ABC transporter signature motif; other site
65093001594	Walker B; other site
65093001595	D-loop; other site
65093001596	H-loop/switch region; other site
65093001597	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
65093001598	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
65093001599	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
65093001600	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093001601	non-specific DNA binding site [nucleotide binding]; other site
65093001602	salt bridge; other site
65093001603	sequence-specific DNA binding site [nucleotide binding]; other site
65093001604	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
65093001605	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65093001606	B12 binding site [chemical binding]; other site
65093001607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093001608	FeS/SAM binding site; other site
65093001609	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
65093001610	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
65093001611	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65093001612	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
65093001613	Putative addiction module component; Region: Unstab_antitox; pfam09720
65093001614	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
65093001615	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
65093001616	homodimer interface [polypeptide binding]; other site
65093001617	substrate-cofactor binding pocket; other site
65093001618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093001619	catalytic residue [active]
65093001620	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
65093001621	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
65093001622	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
65093001623	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
65093001624	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
65093001625	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001626	putative active site [active]
65093001627	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001628	putative active site [active]
65093001629	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001630	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
65093001631	tetramer interface [polypeptide binding]; other site
65093001632	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
65093001633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093001634	catalytic residue [active]
65093001635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093001636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001637	active site
65093001638	phosphorylation site [posttranslational modification]
65093001639	intermolecular recognition site; other site
65093001640	dimerization interface [polypeptide binding]; other site
65093001641	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
65093001642	dimerization interface [polypeptide binding]; other site
65093001643	DNA binding residues [nucleotide binding]
65093001644	Response regulator receiver domain; Region: Response_reg; pfam00072
65093001645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001646	active site
65093001647	phosphorylation site [posttranslational modification]
65093001648	intermolecular recognition site; other site
65093001649	dimerization interface [polypeptide binding]; other site
65093001650	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093001651	dimer interface [polypeptide binding]; other site
65093001652	phosphorylation site [posttranslational modification]
65093001653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093001654	ATP binding site [chemical binding]; other site
65093001655	Mg2+ binding site [ion binding]; other site
65093001656	G-X-G motif; other site
65093001657	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093001658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001659	active site
65093001660	phosphorylation site [posttranslational modification]
65093001661	intermolecular recognition site; other site
65093001662	dimerization interface [polypeptide binding]; other site
65093001663	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
65093001664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093001665	Probable transposase; Region: OrfB_IS605; pfam01385
65093001666	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65093001667	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65093001668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
65093001669	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65093001670	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65093001671	Surface antigen; Region: Bac_surface_Ag; pfam01103
65093001672	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093001673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001674	active site
65093001675	phosphorylation site [posttranslational modification]
65093001676	intermolecular recognition site; other site
65093001677	dimerization interface [polypeptide binding]; other site
65093001678	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093001679	dimerization interface [polypeptide binding]; other site
65093001680	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093001681	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093001682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093001683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093001684	dimer interface [polypeptide binding]; other site
65093001685	putative CheW interface [polypeptide binding]; other site
65093001686	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65093001687	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65093001688	CHASE2 domain; Region: CHASE2; pfam05226
65093001689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093001690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093001691	metal binding site [ion binding]; metal-binding site
65093001692	active site
65093001693	I-site; other site
65093001694	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65093001695	CHASE2 domain; Region: CHASE2; pfam05226
65093001696	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093001697	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093001698	metal binding site [ion binding]; metal-binding site
65093001699	active site
65093001700	I-site; other site
65093001701	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093001702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001703	active site
65093001704	phosphorylation site [posttranslational modification]
65093001705	cytochrome f; Region: petA; CHL00037
65093001706	apocytochrome f; Reviewed; Region: PRK02693
65093001707	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
65093001708	Probable transposase; Region: OrfB_IS605; pfam01385
65093001709	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093001710	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093001711	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
65093001712	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
65093001713	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65093001714	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
65093001715	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093001716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093001717	active site
65093001718	phosphorylation site [posttranslational modification]
65093001719	intermolecular recognition site; other site
65093001720	dimerization interface [polypeptide binding]; other site
65093001721	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093001722	DNA binding site [nucleotide binding]
65093001723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093001724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093001725	dimer interface [polypeptide binding]; other site
65093001726	phosphorylation site [posttranslational modification]
65093001727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093001728	ATP binding site [chemical binding]; other site
65093001729	Mg2+ binding site [ion binding]; other site
65093001730	G-X-G motif; other site
65093001731	RRXRR protein; Region: RRXRR; pfam14239
65093001732	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65093001733	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65093001734	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65093001735	putative active site [active]
65093001736	putative NTP binding site [chemical binding]; other site
65093001737	putative nucleic acid binding site [nucleotide binding]; other site
65093001738	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65093001739	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093001740	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093001741	active site
65093001742	RRXRR protein; Region: RRXRR; pfam14239
65093001743	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
65093001744	TIGR03790 family protein; Region: TIGR03790
65093001745	Flagellin N-methylase; Region: FliB; pfam03692
65093001746	Predicted membrane protein [Function unknown]; Region: COG2119
65093001747	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
65093001748	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093001749	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65093001750	active site
65093001751	catalytic tetrad [active]
65093001752	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
65093001753	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
65093001754	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
65093001755	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
65093001756	homodimer interface [polypeptide binding]; other site
65093001757	Walker A motif; other site
65093001758	ATP binding site [chemical binding]; other site
65093001759	hydroxycobalamin binding site [chemical binding]; other site
65093001760	Walker B motif; other site
65093001761	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65093001762	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
65093001763	putative C-terminal domain interface [polypeptide binding]; other site
65093001764	putative GSH binding site (G-site) [chemical binding]; other site
65093001765	putative dimer interface [polypeptide binding]; other site
65093001766	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65093001767	N-terminal domain interface [polypeptide binding]; other site
65093001768	hypothetical protein; Reviewed; Region: PRK00024
65093001769	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
65093001770	MPN+ (JAMM) motif; other site
65093001771	Zinc-binding site [ion binding]; other site
65093001772	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
65093001773	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
65093001774	heme binding pocket [chemical binding]; other site
65093001775	heme ligand [chemical binding]; other site
65093001776	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093001777	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093001778	catalytic loop [active]
65093001779	iron binding site [ion binding]; other site
65093001780	cobyric acid synthase; Provisional; Region: PRK00784
65093001781	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093001782	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093001783	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
65093001784	catalytic triad [active]
65093001785	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
65093001786	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
65093001787	D1 interface; other site
65093001788	chlorophyll binding site; other site
65093001789	pheophytin binding site; other site
65093001790	beta carotene binding site; other site
65093001791	cytochrome b559 beta interface; other site
65093001792	quinone binding site; other site
65093001793	cytochrome b559 alpha interface; other site
65093001794	protein J interface; other site
65093001795	protein H interface; other site
65093001796	protein X interface; other site
65093001797	core light harvesting protein interface; other site
65093001798	protein L interface; other site
65093001799	CP43 interface; other site
65093001800	protein T interface; other site
65093001801	Fe binding site [ion binding]; other site
65093001802	protein M interface; other site
65093001803	Mn-stabilizing polypeptide interface; other site
65093001804	bromide binding site; other site
65093001805	cytochrome c-550 interface; other site
65093001806	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65093001807	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
65093001808	active site
65093001809	dimer interface [polypeptide binding]; other site
65093001810	metal binding site [ion binding]; metal-binding site
65093001811	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
65093001812	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
65093001813	DctM-like transporters; Region: DctM; pfam06808
65093001814	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
65093001815	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
65093001816	phosphate binding site [ion binding]; other site
65093001817	putative substrate binding pocket [chemical binding]; other site
65093001818	dimer interface [polypeptide binding]; other site
65093001819	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
65093001820	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093001821	putative active site [active]
65093001822	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65093001823	PemK-like protein; Region: PemK; pfam02452
65093001824	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65093001825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093001826	ATP binding site [chemical binding]; other site
65093001827	putative Mg++ binding site [ion binding]; other site
65093001828	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093001829	nucleotide binding region [chemical binding]; other site
65093001830	ATP-binding site [chemical binding]; other site
65093001831	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
65093001832	Repair protein; Region: Repair_PSII; pfam04536
65093001833	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
65093001834	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
65093001835	Short C-terminal domain; Region: SHOCT; pfam09851
65093001836	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093001837	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093001838	Probable transposase; Region: OrfB_IS605; pfam01385
65093001839	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093001840	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
65093001841	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
65093001842	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65093001843	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
65093001844	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
65093001845	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65093001846	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65093001847	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65093001848	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
65093001849	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
65093001850	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
65093001851	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
65093001852	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
65093001853	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
65093001854	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
65093001855	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
65093001856	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
65093001857	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
65093001858	Protein of unknown function DUF86; Region: DUF86; pfam01934
65093001859	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093001860	active site
65093001861	NTP binding site [chemical binding]; other site
65093001862	metal binding triad [ion binding]; metal-binding site
65093001863	antibiotic binding site [chemical binding]; other site
65093001864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65093001865	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
65093001866	WYL domain; Region: WYL; pfam13280
65093001867	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
65093001868	pheophytin binding site; other site
65093001869	chlorophyll binding site; other site
65093001870	quinone binding site; other site
65093001871	Fe binding site [ion binding]; other site
65093001872	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
65093001873	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093001874	putative catalytic residue [active]
65093001875	ABC1 family; Region: ABC1; cl17513
65093001876	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65093001877	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
65093001878	dimer interface [polypeptide binding]; other site
65093001879	substrate binding site [chemical binding]; other site
65093001880	metal binding sites [ion binding]; metal-binding site
65093001881	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
65093001882	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
65093001883	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
65093001884	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
65093001885	shikimate binding site; other site
65093001886	NAD(P) binding site [chemical binding]; other site
65093001887	DNA gyrase subunit A; Validated; Region: PRK05560
65093001888	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
65093001889	CAP-like domain; other site
65093001890	active site
65093001891	primary dimer interface [polypeptide binding]; other site
65093001892	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093001893	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093001894	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093001895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001896	TPR motif; other site
65093001897	binding surface
65093001898	TPR repeat; Region: TPR_11; pfam13414
65093001899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001900	binding surface
65093001901	TPR motif; other site
65093001902	TPR repeat; Region: TPR_11; pfam13414
65093001903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093001904	binding surface
65093001905	TPR motif; other site
65093001906	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
65093001907	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
65093001908	dimer interface [polypeptide binding]; other site
65093001909	catalytic triad [active]
65093001910	adaptive-response sensory kinase; Validated; Region: PRK09303
65093001911	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65093001912	tetramer interface [polypeptide binding]; other site
65093001913	dimer interface [polypeptide binding]; other site
65093001914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093001915	dimer interface [polypeptide binding]; other site
65093001916	phosphorylation site [posttranslational modification]
65093001917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093001918	ATP binding site [chemical binding]; other site
65093001919	Mg2+ binding site [ion binding]; other site
65093001920	G-X-G motif; other site
65093001921	BolA-like protein; Region: BolA; pfam01722
65093001922	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
65093001923	putative GSH binding site [chemical binding]; other site
65093001924	catalytic residues [active]
65093001925	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
65093001926	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
65093001927	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
65093001928	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
65093001929	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65093001930	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65093001931	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65093001932	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
65093001933	FAD binding domain; Region: FAD_binding_4; pfam01565
65093001934	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
65093001935	hypothetical protein; Validated; Region: PRK00153
65093001936	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
65093001937	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093001938	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
65093001939	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
65093001940	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
65093001941	active site
65093001942	Substrate binding site; other site
65093001943	Mg++ binding site; other site
65093001944	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65093001945	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
65093001946	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
65093001947	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
65093001948	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
65093001949	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
65093001950	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65093001951	C-terminal domain interface [polypeptide binding]; other site
65093001952	GSH binding site (G-site) [chemical binding]; other site
65093001953	dimer interface [polypeptide binding]; other site
65093001954	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65093001955	N-terminal domain interface [polypeptide binding]; other site
65093001956	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
65093001957	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
65093001958	putative catalytic cysteine [active]
65093001959	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
65093001960	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
65093001961	putative active site [active]
65093001962	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
65093001963	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
65093001964	homopentamer interface [polypeptide binding]; other site
65093001965	active site
65093001966	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
65093001967	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65093001968	P loop; other site
65093001969	Nucleotide binding site [chemical binding]; other site
65093001970	DTAP/Switch II; other site
65093001971	Switch I; other site
65093001972	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65093001973	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
65093001974	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65093001975	SPFH domain / Band 7 family; Region: Band_7; pfam01145
65093001976	agmatinase; Region: agmatinase; TIGR01230
65093001977	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
65093001978	putative active site [active]
65093001979	Mn binding site [ion binding]; other site
65093001980	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65093001981	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093001982	active site
65093001983	ATP binding site [chemical binding]; other site
65093001984	substrate binding site [chemical binding]; other site
65093001985	activation loop (A-loop); other site
65093001986	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
65093001987	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
65093001988	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65093001989	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65093001990	Peptidase family M23; Region: Peptidase_M23; pfam01551
65093001991	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
65093001992	RNA/DNA hybrid binding site [nucleotide binding]; other site
65093001993	active site
65093001994	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093001995	active site
65093001996	Predicted membrane protein [Function unknown]; Region: COG2324
65093001997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093001998	Coenzyme A binding pocket [chemical binding]; other site
65093001999	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
65093002000	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
65093002001	16S/18S rRNA binding site [nucleotide binding]; other site
65093002002	S13e-L30e interaction site [polypeptide binding]; other site
65093002003	25S rRNA binding site [nucleotide binding]; other site
65093002004	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
65093002005	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
65093002006	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
65093002007	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
65093002008	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
65093002009	putative dimer interface [polypeptide binding]; other site
65093002010	Exoribonuclease R [Transcription]; Region: VacB; COG0557
65093002011	RNB domain; Region: RNB; pfam00773
65093002012	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
65093002013	ribosomal protein L33; Region: rpl33; CHL00104
65093002014	RDD family; Region: RDD; pfam06271
65093002015	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
65093002016	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
65093002017	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
65093002018	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
65093002019	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
65093002020	MOSC domain; Region: MOSC; pfam03473
65093002021	TIGR03943 family protein; Region: TIGR03943
65093002022	Bacterial Ig-like domain; Region: Big_5; pfam13205
65093002023	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65093002024	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65093002025	putative acyl-acceptor binding pocket; other site
65093002026	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
65093002027	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
65093002028	homodimer interface [polypeptide binding]; other site
65093002029	substrate-cofactor binding pocket; other site
65093002030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093002031	catalytic residue [active]
65093002032	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
65093002033	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
65093002034	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
65093002035	putative hydrophobic ligand binding site [chemical binding]; other site
65093002036	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093002037	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093002038	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093002039	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093002040	dimer interface [polypeptide binding]; other site
65093002041	phosphorylation site [posttranslational modification]
65093002042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093002043	ATP binding site [chemical binding]; other site
65093002044	Mg2+ binding site [ion binding]; other site
65093002045	G-X-G motif; other site
65093002046	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
65093002047	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65093002048	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
65093002049	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
65093002050	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65093002051	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65093002052	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
65093002053	IMP binding site; other site
65093002054	dimer interface [polypeptide binding]; other site
65093002055	partial ornithine binding site; other site
65093002056	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
65093002057	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
65093002058	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
65093002059	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093002060	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65093002061	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65093002062	DNA polymerase III subunit beta; Validated; Region: PRK05643
65093002063	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
65093002064	putative DNA binding surface [nucleotide binding]; other site
65093002065	dimer interface [polypeptide binding]; other site
65093002066	beta-clamp/clamp loader binding surface; other site
65093002067	beta-clamp/translesion DNA polymerase binding surface; other site
65093002068	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
65093002069	Fasciclin domain; Region: Fasciclin; pfam02469
65093002070	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65093002071	DNA methylase; Region: N6_N4_Mtase; pfam01555
65093002072	Restriction endonuclease; Region: Mrr_cat; pfam04471
65093002073	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093002074	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093002075	YcfA-like protein; Region: YcfA; cl00752
65093002076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093002077	non-specific DNA binding site [nucleotide binding]; other site
65093002078	salt bridge; other site
65093002079	sequence-specific DNA binding site [nucleotide binding]; other site
65093002080	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
65093002081	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65093002082	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
65093002083	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
65093002084	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093002085	active site
65093002086	NTP binding site [chemical binding]; other site
65093002087	metal binding triad [ion binding]; metal-binding site
65093002088	antibiotic binding site [chemical binding]; other site
65093002089	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65093002090	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
65093002091	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
65093002092	Protein export membrane protein; Region: SecD_SecF; cl14618
65093002093	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
65093002094	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65093002095	active site residue [active]
65093002096	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
65093002097	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65093002098	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093002099	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65093002100	dimerization interface [polypeptide binding]; other site
65093002101	putative DNA binding site [nucleotide binding]; other site
65093002102	putative Zn2+ binding site [ion binding]; other site
65093002103	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093002104	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
65093002105	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093002106	YcfA-like protein; Region: YcfA; pfam07927
65093002107	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093002108	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
65093002109	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
65093002110	Protein required for attachment to host cells; Region: Host_attach; pfam10116
65093002111	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
65093002112	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65093002113	active site residue [active]
65093002114	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65093002115	Predicted transcriptional regulator [Transcription]; Region: COG3682
65093002116	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
65093002117	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
65093002118	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65093002119	P loop; other site
65093002120	Nucleotide binding site [chemical binding]; other site
65093002121	DTAP/Switch II; other site
65093002122	Switch I; other site
65093002123	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
65093002124	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
65093002125	DNA binding residues [nucleotide binding]
65093002126	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082
65093002127	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
65093002128	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
65093002129	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093002130	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65093002131	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002132	putative active site [active]
65093002133	FeoC like transcriptional regulator; Region: FeoC; pfam09012
65093002134	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
65093002135	diiron binding motif [ion binding]; other site
65093002136	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
65093002137	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
65093002138	G1 box; other site
65093002139	GTP/Mg2+ binding site [chemical binding]; other site
65093002140	Switch I region; other site
65093002141	G2 box; other site
65093002142	G3 box; other site
65093002143	Switch II region; other site
65093002144	G4 box; other site
65093002145	G5 box; other site
65093002146	Nucleoside recognition; Region: Gate; pfam07670
65093002147	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
65093002148	Nucleoside recognition; Region: Gate; pfam07670
65093002149	FeoA domain; Region: FeoA; pfam04023
65093002150	FeoA domain; Region: FeoA; pfam04023
65093002151	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65093002152	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65093002153	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
65093002154	substrate binding site [chemical binding]; other site
65093002155	dimer interface [polypeptide binding]; other site
65093002156	ATP binding site [chemical binding]; other site
65093002157	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
65093002158	homotrimer interface [polypeptide binding]; other site
65093002159	Walker A motif; other site
65093002160	GTP binding site [chemical binding]; other site
65093002161	Walker B motif; other site
65093002162	Probable transposase; Region: OrfB_IS605; pfam01385
65093002163	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093002164	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093002165	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65093002166	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
65093002167	catalytic residues [active]
65093002168	catalytic nucleophile [active]
65093002169	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
65093002170	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
65093002171	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
65093002172	protoporphyrinogen oxidase; Region: PLN02576
65093002173	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093002174	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
65093002175	putative active site [active]
65093002176	catalytic residue [active]
65093002177	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
65093002178	nucleoside/Zn binding site; other site
65093002179	dimer interface [polypeptide binding]; other site
65093002180	catalytic motif [active]
65093002181	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
65093002182	GSH binding site [chemical binding]; other site
65093002183	catalytic residues [active]
65093002184	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
65093002185	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
65093002186	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093002187	RNA binding surface [nucleotide binding]; other site
65093002188	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
65093002189	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093002190	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093002191	active site
65093002192	ATP binding site [chemical binding]; other site
65093002193	substrate binding site [chemical binding]; other site
65093002194	activation loop (A-loop); other site
65093002195	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65093002196	WD domain, G-beta repeat; Region: WD40; pfam00400
65093002197	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65093002198	structural tetrad; other site
65093002199	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002200	putative active site [active]
65093002201	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002202	putative active site [active]
65093002203	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65093002204	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65093002205	active site
65093002206	metal binding site [ion binding]; metal-binding site
65093002207	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
65093002208	Trypsin; Region: Trypsin; pfam00089
65093002209	active site
65093002210	substrate binding sites [chemical binding]; other site
65093002211	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093002212	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093002213	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093002214	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093002215	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
65093002216	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
65093002217	trmE is a tRNA modification GTPase; Region: trmE; cd04164
65093002218	G1 box; other site
65093002219	GTP/Mg2+ binding site [chemical binding]; other site
65093002220	Switch I region; other site
65093002221	G2 box; other site
65093002222	Switch II region; other site
65093002223	G3 box; other site
65093002224	G4 box; other site
65093002225	G5 box; other site
65093002226	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
65093002227	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
65093002228	dimer interface [polypeptide binding]; other site
65093002229	motif 1; other site
65093002230	active site
65093002231	motif 2; other site
65093002232	motif 3; other site
65093002233	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65093002234	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
65093002235	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
65093002236	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
65093002237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093002238	Probable transposase; Region: OrfB_IS605; pfam01385
65093002239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093002240	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093002241	putative substrate translocation pore; other site
65093002242	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
65093002243	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
65093002244	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
65093002245	hydrophobic ligand binding site; other site
65093002246	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
65093002247	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
65093002248	Thf1-like protein; Reviewed; Region: PRK13266
65093002249	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
65093002250	hypothetical protein; Provisional; Region: PRK04194
65093002251	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
65093002252	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65093002253	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
65093002254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093002255	Probable transposase; Region: OrfB_IS605; pfam01385
65093002256	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093002257	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
65093002258	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
65093002259	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093002260	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093002261	catalytic loop [active]
65093002262	iron binding site [ion binding]; other site
65093002263	spermidine synthase; Provisional; Region: PRK00811
65093002264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093002265	S-adenosylmethionine binding site [chemical binding]; other site
65093002266	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
65093002267	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
65093002268	catalytic site [active]
65093002269	G-X2-G-X-G-K; other site
65093002270	hypothetical protein; Provisional; Region: PRK04323
65093002271	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
65093002272	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
65093002273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093002274	S-adenosylmethionine binding site [chemical binding]; other site
65093002275	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
65093002276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093002277	Walker A/P-loop; other site
65093002278	ATP binding site [chemical binding]; other site
65093002279	Q-loop/lid; other site
65093002280	ABC transporter signature motif; other site
65093002281	Walker B; other site
65093002282	D-loop; other site
65093002283	H-loop/switch region; other site
65093002284	TOBE domain; Region: TOBE_2; pfam08402
65093002285	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
65093002286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093002287	dimer interface [polypeptide binding]; other site
65093002288	conserved gate region; other site
65093002289	putative PBP binding loops; other site
65093002290	ABC-ATPase subunit interface; other site
65093002291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093002292	dimer interface [polypeptide binding]; other site
65093002293	conserved gate region; other site
65093002294	putative PBP binding loops; other site
65093002295	ABC-ATPase subunit interface; other site
65093002296	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65093002297	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
65093002298	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
65093002299	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
65093002300	Ion channel; Region: Ion_trans_2; pfam07885
65093002301	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65093002302	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65093002303	Response regulator receiver domain; Region: Response_reg; pfam00072
65093002304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002305	active site
65093002306	phosphorylation site [posttranslational modification]
65093002307	intermolecular recognition site; other site
65093002308	dimerization interface [polypeptide binding]; other site
65093002309	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
65093002310	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65093002311	nucleotide binding site [chemical binding]; other site
65093002312	NEF interaction site [polypeptide binding]; other site
65093002313	SBD interface [polypeptide binding]; other site
65093002314	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
65093002315	ribonuclease P; Reviewed; Region: rnpA; PRK03031
65093002316	Bacterial PH domain; Region: DUF304; pfam03703
65093002317	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
65093002318	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
65093002319	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
65093002320	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
65093002321	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
65093002322	G-X-X-G motif; other site
65093002323	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
65093002324	RxxxH motif; other site
65093002325	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
65093002326	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
65093002327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093002328	FeS/SAM binding site; other site
65093002329	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002330	putative active site [active]
65093002331	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
65093002332	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
65093002333	putative NAD(P) binding site [chemical binding]; other site
65093002334	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65093002335	PGAP1-like protein; Region: PGAP1; pfam07819
65093002336	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
65093002337	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65093002338	dimer interface [polypeptide binding]; other site
65093002339	[2Fe-2S] cluster binding site [ion binding]; other site
65093002340	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093002341	GAF domain; Region: GAF_3; pfam13492
65093002342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093002343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093002344	dimer interface [polypeptide binding]; other site
65093002345	phosphorylation site [posttranslational modification]
65093002346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093002347	ATP binding site [chemical binding]; other site
65093002348	Mg2+ binding site [ion binding]; other site
65093002349	G-X-G motif; other site
65093002350	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093002351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002352	active site
65093002353	phosphorylation site [posttranslational modification]
65093002354	intermolecular recognition site; other site
65093002355	dimerization interface [polypeptide binding]; other site
65093002356	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
65093002357	active site
65093002358	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65093002359	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65093002360	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65093002361	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
65093002362	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65093002363	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
65093002364	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
65093002365	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
65093002366	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
65093002367	RNase E interface [polypeptide binding]; other site
65093002368	trimer interface [polypeptide binding]; other site
65093002369	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
65093002370	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
65093002371	RNase E interface [polypeptide binding]; other site
65093002372	trimer interface [polypeptide binding]; other site
65093002373	active site
65093002374	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
65093002375	putative nucleic acid binding region [nucleotide binding]; other site
65093002376	G-X-X-G motif; other site
65093002377	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
65093002378	RNA binding site [nucleotide binding]; other site
65093002379	domain interface; other site
65093002380	SNF2 Helicase protein; Region: DUF3670; pfam12419
65093002381	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
65093002382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093002383	ATP binding site [chemical binding]; other site
65093002384	putative Mg++ binding site [ion binding]; other site
65093002385	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093002386	nucleotide binding region [chemical binding]; other site
65093002387	ATP-binding site [chemical binding]; other site
65093002388	Predicted membrane protein [Function unknown]; Region: COG3431
65093002389	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
65093002390	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
65093002391	hinge; other site
65093002392	active site
65093002393	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
65093002394	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
65093002395	PLD-like domain; Region: PLDc_2; pfam13091
65093002396	putative active site [active]
65093002397	catalytic site [active]
65093002398	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
65093002399	putative active site [active]
65093002400	catalytic site [active]
65093002401	Part of AAA domain; Region: AAA_19; pfam13245
65093002402	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
65093002403	AAA domain; Region: AAA_12; pfam13087
65093002404	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
65093002405	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
65093002406	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
65093002407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65093002408	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
65093002409	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
65093002410	nucleotide binding site [chemical binding]; other site
65093002411	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
65093002412	RNA/DNA hybrid binding site [nucleotide binding]; other site
65093002413	active site
65093002414	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
65093002415	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
65093002416	prephenate dehydratase; Provisional; Region: PRK11898
65093002417	Prephenate dehydratase; Region: PDT; pfam00800
65093002418	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
65093002419	putative L-Phe binding site [chemical binding]; other site
65093002420	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
65093002421	PLD-like domain; Region: PLDc_2; pfam13091
65093002422	putative active site [active]
65093002423	catalytic site [active]
65093002424	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
65093002425	PLD-like domain; Region: PLDc_2; pfam13091
65093002426	putative active site [active]
65093002427	catalytic site [active]
65093002428	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65093002429	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65093002430	dimerization interface [polypeptide binding]; other site
65093002431	DPS ferroxidase diiron center [ion binding]; other site
65093002432	ion pore; other site
65093002433	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002434	putative active site [active]
65093002435	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
65093002436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
65093002437	Histidine kinase; Region: HisKA_3; pfam07730
65093002438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093002439	ATP binding site [chemical binding]; other site
65093002440	Mg2+ binding site [ion binding]; other site
65093002441	G-X-G motif; other site
65093002442	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093002443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002444	active site
65093002445	phosphorylation site [posttranslational modification]
65093002446	intermolecular recognition site; other site
65093002447	dimerization interface [polypeptide binding]; other site
65093002448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093002449	DNA binding residues [nucleotide binding]
65093002450	dimerization interface [polypeptide binding]; other site
65093002451	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
65093002452	active site
65093002453	SAM binding site [chemical binding]; other site
65093002454	homodimer interface [polypeptide binding]; other site
65093002455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093002456	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65093002457	NADPH bind site [chemical binding]; other site
65093002458	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65093002459	putative FMN binding site [chemical binding]; other site
65093002460	NADPH bind site [chemical binding]; other site
65093002461	aromatic acid decarboxylase; Validated; Region: PRK05920
65093002462	Flavoprotein; Region: Flavoprotein; pfam02441
65093002463	Exoribonuclease R [Transcription]; Region: VacB; COG0557
65093002464	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
65093002465	RNB domain; Region: RNB; pfam00773
65093002466	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
65093002467	RNA binding site [nucleotide binding]; other site
65093002468	Clp protease; Region: CLP_protease; pfam00574
65093002469	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65093002470	oligomer interface [polypeptide binding]; other site
65093002471	active site residues [active]
65093002472	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
65093002473	MoaE homodimer interface [polypeptide binding]; other site
65093002474	MoaD interaction [polypeptide binding]; other site
65093002475	active site residues [active]
65093002476	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
65093002477	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
65093002478	Walker A/P-loop; other site
65093002479	ATP binding site [chemical binding]; other site
65093002480	Q-loop/lid; other site
65093002481	ABC transporter signature motif; other site
65093002482	Walker B; other site
65093002483	D-loop; other site
65093002484	H-loop/switch region; other site
65093002485	TOBE domain; Region: TOBE_2; pfam08402
65093002486	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65093002487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093002488	NAD(P) binding site [chemical binding]; other site
65093002489	active site
65093002490	allophycocyanin, beta subunit; Region: apcB; TIGR01337
65093002491	DNA adenine methylase (dam); Region: dam; TIGR00571
65093002492	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093002493	active site
65093002494	NTP binding site [chemical binding]; other site
65093002495	metal binding triad [ion binding]; metal-binding site
65093002496	antibiotic binding site [chemical binding]; other site
65093002497	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
65093002498	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
65093002499	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
65093002500	acyl-ACP reductase; Provisional; Region: PRK14982
65093002501	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
65093002502	NAD(P) binding pocket [chemical binding]; other site
65093002503	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
65093002504	dinuclear metal binding motif [ion binding]; other site
65093002505	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
65093002506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093002507	dimer interface [polypeptide binding]; other site
65093002508	conserved gate region; other site
65093002509	putative PBP binding loops; other site
65093002510	ABC-ATPase subunit interface; other site
65093002511	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
65093002512	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
65093002513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
65093002514	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093002515	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
65093002516	putative ADP-binding pocket [chemical binding]; other site
65093002517	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
65093002518	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
65093002519	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
65093002520	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
65093002521	dimer interface [polypeptide binding]; other site
65093002522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093002523	catalytic residue [active]
65093002524	BON domain; Region: BON; pfam04972
65093002525	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
65093002526	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
65093002527	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
65093002528	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
65093002529	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
65093002530	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093002531	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
65093002532	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093002533	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
65093002534	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65093002535	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65093002536	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093002537	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
65093002538	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65093002539	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65093002540	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002541	putative active site [active]
65093002542	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
65093002543	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65093002544	Walker A/P-loop; other site
65093002545	ATP binding site [chemical binding]; other site
65093002546	Q-loop/lid; other site
65093002547	ABC transporter signature motif; other site
65093002548	Walker B; other site
65093002549	D-loop; other site
65093002550	H-loop/switch region; other site
65093002551	FtsX-like permease family; Region: FtsX; pfam02687
65093002552	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65093002553	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
65093002554	FtsX-like permease family; Region: FtsX; pfam02687
65093002555	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093002556	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093002557	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093002558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002559	binding surface
65093002560	TPR motif; other site
65093002561	TPR repeat; Region: TPR_11; pfam13414
65093002562	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093002563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002564	binding surface
65093002565	TPR motif; other site
65093002566	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
65093002567	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
65093002568	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
65093002569	substrate binding pocket [chemical binding]; other site
65093002570	chain length determination region; other site
65093002571	substrate-Mg2+ binding site; other site
65093002572	catalytic residues [active]
65093002573	aspartate-rich region 1; other site
65093002574	active site lid residues [active]
65093002575	aspartate-rich region 2; other site
65093002576	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
65093002577	Fe-S cluster binding site [ion binding]; other site
65093002578	active site
65093002579	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
65093002580	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093002581	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65093002582	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093002583	DNA binding residues [nucleotide binding]
65093002584	ribosome recycling factor; Reviewed; Region: frr; PRK00083
65093002585	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
65093002586	hinge region; other site
65093002587	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
65093002588	putative nucleotide binding site [chemical binding]; other site
65093002589	uridine monophosphate binding site [chemical binding]; other site
65093002590	homohexameric interface [polypeptide binding]; other site
65093002591	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093002592	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093002593	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65093002594	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
65093002595	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65093002596	TrkA-N domain; Region: TrkA_N; pfam02254
65093002597	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65093002598	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
65093002599	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65093002600	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65093002601	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093002602	catalytic residue [active]
65093002603	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
65093002604	RNase_H superfamily; Region: RNase_H_2; pfam13482
65093002605	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093002606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093002607	S-adenosylmethionine binding site [chemical binding]; other site
65093002608	S4 domain; Region: S4_2; pfam13275
65093002609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
65093002610	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
65093002611	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
65093002612	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
65093002613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093002614	S-adenosylmethionine binding site [chemical binding]; other site
65093002615	TPR repeat; Region: TPR_11; pfam13414
65093002616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002617	TPR motif; other site
65093002618	binding surface
65093002619	CHASE3 domain; Region: CHASE3; cl05000
65093002620	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093002621	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093002622	dimer interface [polypeptide binding]; other site
65093002623	putative CheW interface [polypeptide binding]; other site
65093002624	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65093002625	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65093002626	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093002627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002628	active site
65093002629	phosphorylation site [posttranslational modification]
65093002630	intermolecular recognition site; other site
65093002631	dimerization interface [polypeptide binding]; other site
65093002632	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093002633	putative binding surface; other site
65093002634	active site
65093002635	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093002636	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093002637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093002638	ATP binding site [chemical binding]; other site
65093002639	Mg2+ binding site [ion binding]; other site
65093002640	G-X-G motif; other site
65093002641	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
65093002642	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093002643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002644	active site
65093002645	phosphorylation site [posttranslational modification]
65093002646	intermolecular recognition site; other site
65093002647	dimerization interface [polypeptide binding]; other site
65093002648	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
65093002649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002650	active site
65093002651	phosphorylation site [posttranslational modification]
65093002652	intermolecular recognition site; other site
65093002653	dimerization interface [polypeptide binding]; other site
65093002654	CheB methylesterase; Region: CheB_methylest; pfam01339
65093002655	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
65093002656	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
65093002657	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65093002658	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
65093002659	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65093002660	putative ribose interaction site [chemical binding]; other site
65093002661	putative ADP binding site [chemical binding]; other site
65093002662	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
65093002663	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
65093002664	active site
65093002665	Substrate binding site; other site
65093002666	Mg++ binding site; other site
65093002667	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65093002668	putative trimer interface [polypeptide binding]; other site
65093002669	putative CoA binding site [chemical binding]; other site
65093002670	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
65093002671	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
65093002672	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
65093002673	dimerization interface [polypeptide binding]; other site
65093002674	putative active cleft [active]
65093002675	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093002676	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
65093002677	catalytic triad [active]
65093002678	putative active site [active]
65093002679	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
65093002680	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65093002681	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
65093002682	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
65093002683	spermidine synthase; Provisional; Region: PRK03612
65093002684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093002685	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
65093002686	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093002687	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093002688	catalytic loop [active]
65093002689	iron binding site [ion binding]; other site
65093002690	TPR repeat; Region: TPR_11; pfam13414
65093002691	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65093002692	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65093002693	putative ligand binding site [chemical binding]; other site
65093002694	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65093002695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
65093002696	cobalt transport protein CbiM; Validated; Region: PRK06265
65093002697	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
65093002698	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
65093002699	TPR repeat; Region: TPR_11; pfam13414
65093002700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002701	binding surface
65093002702	TPR motif; other site
65093002703	TPR repeat; Region: TPR_11; pfam13414
65093002704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002705	binding surface
65093002706	TPR motif; other site
65093002707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093002708	binding surface
65093002709	TPR motif; other site
65093002710	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093002711	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
65093002712	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
65093002713	active site
65093002714	catalytic site [active]
65093002715	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
65093002716	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
65093002717	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
65093002718	active site
65093002719	substrate binding site [chemical binding]; other site
65093002720	cosubstrate binding site; other site
65093002721	catalytic site [active]
65093002722	YCII-related domain; Region: YCII; cl00999
65093002723	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
65093002724	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
65093002725	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
65093002726	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
65093002727	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
65093002728	active site
65093002729	homodimer interface [polypeptide binding]; other site
65093002730	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
65093002731	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
65093002732	catalytic residue [active]
65093002733	putative FPP diphosphate  binding site; other site
65093002734	putative FPP binding hydrophobic cleft; other site
65093002735	dimer interface [polypeptide binding]; other site
65093002736	putative IPP diphosphate binding site; other site
65093002737	Uncharacterized conserved protein [Function unknown]; Region: COG1624
65093002738	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
65093002739	diaminopimelate decarboxylase; Region: lysA; TIGR01048
65093002740	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
65093002741	active site
65093002742	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65093002743	substrate binding site [chemical binding]; other site
65093002744	catalytic residues [active]
65093002745	dimer interface [polypeptide binding]; other site
65093002746	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093002747	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093002748	putative active site [active]
65093002749	recombination protein F; Reviewed; Region: recF; PRK00064
65093002750	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
65093002751	Walker A/P-loop; other site
65093002752	ATP binding site [chemical binding]; other site
65093002753	Q-loop/lid; other site
65093002754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093002755	ABC transporter signature motif; other site
65093002756	Walker B; other site
65093002757	D-loop; other site
65093002758	H-loop/switch region; other site
65093002759	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
65093002760	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093002761	active site
65093002762	catalytic tetrad [active]
65093002763	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
65093002764	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
65093002765	HAMP domain; Region: HAMP; pfam00672
65093002766	PAS fold; Region: PAS_4; pfam08448
65093002767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093002768	putative active site [active]
65093002769	heme pocket [chemical binding]; other site
65093002770	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093002771	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093002772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093002773	dimer interface [polypeptide binding]; other site
65093002774	phosphorylation site [posttranslational modification]
65093002775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093002776	ATP binding site [chemical binding]; other site
65093002777	Mg2+ binding site [ion binding]; other site
65093002778	G-X-G motif; other site
65093002779	Response regulator receiver domain; Region: Response_reg; pfam00072
65093002780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002781	active site
65093002782	phosphorylation site [posttranslational modification]
65093002783	intermolecular recognition site; other site
65093002784	dimerization interface [polypeptide binding]; other site
65093002785	Response regulator receiver domain; Region: Response_reg; pfam00072
65093002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002787	active site
65093002788	phosphorylation site [posttranslational modification]
65093002789	intermolecular recognition site; other site
65093002790	dimerization interface [polypeptide binding]; other site
65093002791	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093002792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002793	active site
65093002794	phosphorylation site [posttranslational modification]
65093002795	intermolecular recognition site; other site
65093002796	dimerization interface [polypeptide binding]; other site
65093002797	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093002798	DNA binding site [nucleotide binding]
65093002799	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
65093002800	ATP-NAD kinase; Region: NAD_kinase; pfam01513
65093002801	Ycf39; Provisional; Region: ycf39; CHL00194
65093002802	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65093002803	NAD(P) binding site [chemical binding]; other site
65093002804	putative active site [active]
65093002805	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
65093002806	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
65093002807	Tetramer interface [polypeptide binding]; other site
65093002808	active site
65093002809	FMN-binding site [chemical binding]; other site
65093002810	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
65093002811	catalytic motif [active]
65093002812	Catalytic residue [active]
65093002813	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
65093002814	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
65093002815	hexamer interface [polypeptide binding]; other site
65093002816	ligand binding site [chemical binding]; other site
65093002817	putative active site [active]
65093002818	NAD(P) binding site [chemical binding]; other site
65093002819	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
65093002820	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
65093002821	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
65093002822	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
65093002823	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
65093002824	Walker A motif; other site
65093002825	ATP binding site [chemical binding]; other site
65093002826	Walker B motif; other site
65093002827	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
65093002828	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
65093002829	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
65093002830	Walker A motif; other site
65093002831	ATP binding site [chemical binding]; other site
65093002832	Walker B motif; other site
65093002833	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
65093002834	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
65093002835	P-loop; other site
65093002836	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
65093002837	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
65093002838	PetN; Region: PetN; pfam03742
65093002839	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
65093002840	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
65093002841	RNA binding site [nucleotide binding]; other site
65093002842	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
65093002843	RNA binding site [nucleotide binding]; other site
65093002844	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
65093002845	RNA binding site [nucleotide binding]; other site
65093002846	Dienelactone hydrolase family; Region: DLH; pfam01738
65093002847	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
65093002848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093002849	Probable transposase; Region: OrfB_IS605; pfam01385
65093002850	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093002851	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
65093002852	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65093002853	Walker A/P-loop; other site
65093002854	ATP binding site [chemical binding]; other site
65093002855	Q-loop/lid; other site
65093002856	ABC transporter signature motif; other site
65093002857	Walker B; other site
65093002858	D-loop; other site
65093002859	H-loop/switch region; other site
65093002860	DevC protein; Region: devC; TIGR01185
65093002861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65093002862	FtsX-like permease family; Region: FtsX; pfam02687
65093002863	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
65093002864	active site
65093002865	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093002866	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
65093002867	putative RNA binding site [nucleotide binding]; other site
65093002868	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
65093002869	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
65093002870	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
65093002871	P loop; other site
65093002872	GTP binding site [chemical binding]; other site
65093002873	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
65093002874	KaiA domain; Region: KaiA; pfam07688
65093002875	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65093002876	tetramer interface [polypeptide binding]; other site
65093002877	dimer interface [polypeptide binding]; other site
65093002878	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
65093002879	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
65093002880	Walker A motif; other site
65093002881	ATP binding site [chemical binding]; other site
65093002882	Walker B motif; other site
65093002883	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65093002884	ATP binding site [chemical binding]; other site
65093002885	Walker B motif; other site
65093002886	polyphosphate kinase; Provisional; Region: PRK05443
65093002887	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
65093002888	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
65093002889	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
65093002890	putative domain interface [polypeptide binding]; other site
65093002891	putative active site [active]
65093002892	catalytic site [active]
65093002893	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
65093002894	putative domain interface [polypeptide binding]; other site
65093002895	putative active site [active]
65093002896	catalytic site [active]
65093002897	hypothetical protein; Reviewed; Region: PRK12497
65093002898	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
65093002899	MPT binding site; other site
65093002900	trimer interface [polypeptide binding]; other site
65093002901	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65093002902	hypothetical protein; Provisional; Region: PRK06849
65093002903	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65093002904	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
65093002905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093002906	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
65093002907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093002908	putative substrate translocation pore; other site
65093002909	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093002910	Probable transposase; Region: OrfB_IS605; pfam01385
65093002911	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093002912	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093002913	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
65093002914	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65093002915	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093002916	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65093002917	oligomeric interface; other site
65093002918	putative active site [active]
65093002919	homodimer interface [polypeptide binding]; other site
65093002920	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
65093002921	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
65093002922	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
65093002923	TPP-binding site; other site
65093002924	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
65093002925	PYR/PP interface [polypeptide binding]; other site
65093002926	dimer interface [polypeptide binding]; other site
65093002927	TPP binding site [chemical binding]; other site
65093002928	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65093002929	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093002930	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65093002931	Walker A/P-loop; other site
65093002932	ATP binding site [chemical binding]; other site
65093002933	Q-loop/lid; other site
65093002934	ABC transporter signature motif; other site
65093002935	Walker B; other site
65093002936	D-loop; other site
65093002937	H-loop/switch region; other site
65093002938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093002939	Probable transposase; Region: OrfB_IS605; pfam01385
65093002940	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093002941	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
65093002942	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
65093002943	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65093002944	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093002945	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093002946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093002947	ligand binding site [chemical binding]; other site
65093002948	flexible hinge region; other site
65093002949	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
65093002950	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
65093002951	putative active site [active]
65093002952	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093002953	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65093002954	Walker A/P-loop; other site
65093002955	ATP binding site [chemical binding]; other site
65093002956	Q-loop/lid; other site
65093002957	ABC transporter signature motif; other site
65093002958	Walker B; other site
65093002959	D-loop; other site
65093002960	H-loop/switch region; other site
65093002961	EamA-like transporter family; Region: EamA; pfam00892
65093002962	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
65093002963	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
65093002964	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
65093002965	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65093002966	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
65093002967	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65093002968	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65093002969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093002970	AAA domain; Region: AAA_23; pfam13476
65093002971	Walker A/P-loop; other site
65093002972	ATP binding site [chemical binding]; other site
65093002973	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093002974	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
65093002975	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
65093002976	Ycf35; Provisional; Region: ycf35; CHL00193
65093002977	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
65093002978	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65093002979	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093002980	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093002981	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093002982	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093002983	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
65093002984	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
65093002985	DnaJ domain; Region: DnaJ; pfam00226
65093002986	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
65093002987	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093002988	active site
65093002989	catalytic tetrad [active]
65093002990	Bifunctional nuclease; Region: DNase-RNase; pfam02577
65093002991	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
65093002992	Lumazine binding domain; Region: Lum_binding; pfam00677
65093002993	Lumazine binding domain; Region: Lum_binding; pfam00677
65093002994	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65093002995	Peptidase family M23; Region: Peptidase_M23; pfam01551
65093002996	Ycf27; Reviewed; Region: orf27; CHL00148
65093002997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093002998	active site
65093002999	phosphorylation site [posttranslational modification]
65093003000	intermolecular recognition site; other site
65093003001	dimerization interface [polypeptide binding]; other site
65093003002	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093003003	DNA binding site [nucleotide binding]
65093003004	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
65093003005	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
65093003006	RNA binding site [nucleotide binding]; other site
65093003007	active site
65093003008	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
65093003009	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
65093003010	E3 interaction surface; other site
65093003011	lipoyl attachment site [posttranslational modification]; other site
65093003012	e3 binding domain; Region: E3_binding; pfam02817
65093003013	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
65093003014	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
65093003015	Response regulator receiver domain; Region: Response_reg; pfam00072
65093003016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093003017	active site
65093003018	phosphorylation site [posttranslational modification]
65093003019	intermolecular recognition site; other site
65093003020	dimerization interface [polypeptide binding]; other site
65093003021	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093003022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093003023	active site
65093003024	phosphorylation site [posttranslational modification]
65093003025	intermolecular recognition site; other site
65093003026	dimerization interface [polypeptide binding]; other site
65093003027	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
65093003028	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093003029	dimerization interface [polypeptide binding]; other site
65093003030	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093003031	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093003032	dimer interface [polypeptide binding]; other site
65093003033	putative CheW interface [polypeptide binding]; other site
65093003034	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093003035	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093003036	putative binding surface; other site
65093003037	active site
65093003038	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093003039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093003040	ATP binding site [chemical binding]; other site
65093003041	Mg2+ binding site [ion binding]; other site
65093003042	G-X-G motif; other site
65093003043	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093003044	Response regulator receiver domain; Region: Response_reg; pfam00072
65093003045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093003046	active site
65093003047	phosphorylation site [posttranslational modification]
65093003048	intermolecular recognition site; other site
65093003049	dimerization interface [polypeptide binding]; other site
65093003050	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65093003051	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65093003052	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65093003053	Ligand Binding Site [chemical binding]; other site
65093003054	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093003055	Ligand Binding Site [chemical binding]; other site
65093003056	GMP synthase; Reviewed; Region: guaA; PRK00074
65093003057	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
65093003058	AMP/PPi binding site [chemical binding]; other site
65093003059	candidate oxyanion hole; other site
65093003060	catalytic triad [active]
65093003061	potential glutamine specificity residues [chemical binding]; other site
65093003062	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
65093003063	ATP Binding subdomain [chemical binding]; other site
65093003064	Ligand Binding sites [chemical binding]; other site
65093003065	Dimerization subdomain; other site
65093003066	TPR repeat; Region: TPR_11; pfam13414
65093003067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003068	binding surface
65093003069	TPR motif; other site
65093003070	TPR repeat; Region: TPR_11; pfam13414
65093003071	TPR repeat; Region: TPR_11; pfam13414
65093003072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003073	TPR motif; other site
65093003074	binding surface
65093003075	TPR repeat; Region: TPR_11; pfam13414
65093003076	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093003078	L-aspartate oxidase; Provisional; Region: PRK06175
65093003079	L-aspartate oxidase; Provisional; Region: PRK07395
65093003080	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
65093003081	tol-pal system protein YbgF; Provisional; Region: PRK10803
65093003082	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
65093003083	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
65093003084	dimer interface [polypeptide binding]; other site
65093003085	anticodon binding site; other site
65093003086	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
65093003087	homodimer interface [polypeptide binding]; other site
65093003088	motif 1; other site
65093003089	active site
65093003090	motif 2; other site
65093003091	GAD domain; Region: GAD; pfam02938
65093003092	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
65093003093	active site
65093003094	motif 3; other site
65093003095	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093003096	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093003097	ligand binding site [chemical binding]; other site
65093003098	flexible hinge region; other site
65093003099	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093003100	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093003101	ligand binding site [chemical binding]; other site
65093003102	flexible hinge region; other site
65093003103	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
65093003104	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
65093003105	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
65093003106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093003107	ABC-ATPase subunit interface; other site
65093003108	putative PBP binding loops; other site
65093003109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
65093003110	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
65093003111	AAA domain; Region: AAA_18; pfam13238
65093003112	ligand-binding site [chemical binding]; other site
65093003113	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
65093003114	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
65093003115	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
65093003116	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
65093003117	active site
65093003118	putative DNA-binding cleft [nucleotide binding]; other site
65093003119	dimer interface [polypeptide binding]; other site
65093003120	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
65093003121	metal binding site [ion binding]; metal-binding site
65093003122	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
65093003123	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
65093003124	Peptidase family M50; Region: Peptidase_M50; pfam02163
65093003125	active site
65093003126	putative substrate binding region [chemical binding]; other site
65093003127	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
65093003128	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
65093003129	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
65093003130	UGMP family protein; Validated; Region: PRK09604
65093003131	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
65093003132	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
65093003133	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
65093003134	active site
65093003135	interdomain interaction site; other site
65093003136	putative metal-binding site [ion binding]; other site
65093003137	nucleotide binding site [chemical binding]; other site
65093003138	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
65093003139	domain I; other site
65093003140	phosphate binding site [ion binding]; other site
65093003141	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
65093003142	domain II; other site
65093003143	domain III; other site
65093003144	nucleotide binding site [chemical binding]; other site
65093003145	DNA binding groove [nucleotide binding]
65093003146	catalytic site [active]
65093003147	domain IV; other site
65093003148	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65093003149	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65093003150	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65093003151	TMAO/DMSO reductase; Reviewed; Region: PRK05363
65093003152	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
65093003153	Moco binding site; other site
65093003154	metal coordination site [ion binding]; other site
65093003155	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
65093003156	Sm and related proteins; Region: Sm_like; cl00259
65093003157	ribosome maturation protein RimP; Reviewed; Region: PRK00092
65093003158	heptamer interface [polypeptide binding]; other site
65093003159	Sm1 motif; other site
65093003160	hexamer interface [polypeptide binding]; other site
65093003161	RNA binding site [nucleotide binding]; other site
65093003162	Sm2 motif; other site
65093003163	NusA N-terminal domain; Region: NusA_N; pfam08529
65093003164	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
65093003165	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
65093003166	RNA binding site [nucleotide binding]; other site
65093003167	homodimer interface [polypeptide binding]; other site
65093003168	NusA-like KH domain; Region: KH_5; pfam13184
65093003169	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
65093003170	G-X-X-G motif; other site
65093003171	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
65093003172	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
65093003173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093003174	ATP binding site [chemical binding]; other site
65093003175	Mg2+ binding site [ion binding]; other site
65093003176	G-X-G motif; other site
65093003177	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
65093003178	ATP binding site [chemical binding]; other site
65093003179	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
65093003180	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093003181	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
65093003182	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
65093003183	Low molecular weight phosphatase family; Region: LMWPc; cd00115
65093003184	active site
65093003185	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65093003186	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
65093003187	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
65093003188	aromatic arch; other site
65093003189	DCoH dimer interaction site [polypeptide binding]; other site
65093003190	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
65093003191	DCoH tetramer interaction site [polypeptide binding]; other site
65093003192	substrate binding site [chemical binding]; other site
65093003193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003194	TPR repeat; Region: TPR_11; pfam13414
65093003195	binding surface
65093003196	TPR motif; other site
65093003197	TPR repeat; Region: TPR_11; pfam13414
65093003198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003199	binding surface
65093003200	TPR motif; other site
65093003201	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093003202	Cation efflux family; Region: Cation_efflux; pfam01545
65093003203	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65093003204	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093003205	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093003206	motif I; other site
65093003207	motif II; other site
65093003208	EVE domain; Region: EVE; cl00728
65093003209	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093003210	active site
65093003211	NTP binding site [chemical binding]; other site
65093003212	metal binding triad [ion binding]; metal-binding site
65093003213	antibiotic binding site [chemical binding]; other site
65093003214	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
65093003215	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
65093003216	DNA binding residues [nucleotide binding]
65093003217	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
65093003218	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
65093003219	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093003220	ATP binding site [chemical binding]; other site
65093003221	putative Mg++ binding site [ion binding]; other site
65093003222	nucleotide binding region [chemical binding]; other site
65093003223	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
65093003224	ATP-binding site [chemical binding]; other site
65093003225	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
65093003226	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65093003227	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65093003228	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093003229	Protein of unknown function (DUF433); Region: DUF433; cl01030
65093003230	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093003231	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
65093003232	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093003233	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65093003234	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65093003235	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
65093003236	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093003237	putative active site [active]
65093003238	Homeodomain-like domain; Region: HTH_23; pfam13384
65093003239	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093003240	non-specific DNA binding site [nucleotide binding]; other site
65093003241	salt bridge; other site
65093003242	sequence-specific DNA binding site [nucleotide binding]; other site
65093003243	Uncharacterized conserved protein [Function unknown]; Region: COG1479
65093003244	Protein of unknown function DUF262; Region: DUF262; pfam03235
65093003245	Uncharacterized conserved protein [Function unknown]; Region: COG3472
65093003246	TIR domain; Region: TIR_2; pfam13676
65093003247	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093003248	active site
65093003249	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
65093003250	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
65093003251	putative dimer interface [polypeptide binding]; other site
65093003252	putative anticodon binding site; other site
65093003253	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
65093003254	homodimer interface [polypeptide binding]; other site
65093003255	motif 1; other site
65093003256	motif 2; other site
65093003257	active site
65093003258	motif 3; other site
65093003259	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
65093003260	Transglycosylase; Region: Transgly; pfam00912
65093003261	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
65093003262	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65093003263	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
65093003264	Predicted deacylase [General function prediction only]; Region: COG3608
65093003265	active site
65093003266	Zn binding site [ion binding]; other site
65093003267	GTPase Era; Reviewed; Region: era; PRK00089
65093003268	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
65093003269	G1 box; other site
65093003270	GTP/Mg2+ binding site [chemical binding]; other site
65093003271	Switch I region; other site
65093003272	G2 box; other site
65093003273	Switch II region; other site
65093003274	G3 box; other site
65093003275	G4 box; other site
65093003276	G5 box; other site
65093003277	KH domain; Region: KH_2; pfam07650
65093003278	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093003279	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093003280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093003281	ATP binding site [chemical binding]; other site
65093003282	Mg2+ binding site [ion binding]; other site
65093003283	G-X-G motif; other site
65093003284	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
65093003285	Response regulator receiver domain; Region: Response_reg; pfam00072
65093003286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093003287	active site
65093003288	phosphorylation site [posttranslational modification]
65093003289	intermolecular recognition site; other site
65093003290	dimerization interface [polypeptide binding]; other site
65093003291	Stage II sporulation protein; Region: SpoIID; pfam08486
65093003292	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
65093003293	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093003294	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
65093003295	ligand binding site [chemical binding]; other site
65093003296	flexible hinge region; other site
65093003297	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65093003298	putative switch regulator; other site
65093003299	non-specific DNA interactions [nucleotide binding]; other site
65093003300	DNA binding site [nucleotide binding]
65093003301	sequence specific DNA binding site [nucleotide binding]; other site
65093003302	putative cAMP binding site [chemical binding]; other site
65093003303	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
65093003304	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
65093003305	Protein of unknown function (DUF972); Region: DUF972; pfam06156
65093003306	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
65093003307	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
65093003308	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
65093003309	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65093003310	Clp protease ATP binding subunit; Region: clpC; CHL00095
65093003311	Clp amino terminal domain; Region: Clp_N; pfam02861
65093003312	Clp amino terminal domain; Region: Clp_N; pfam02861
65093003313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093003314	Walker A motif; other site
65093003315	ATP binding site [chemical binding]; other site
65093003316	Walker B motif; other site
65093003317	arginine finger; other site
65093003318	UvrB/uvrC motif; Region: UVR; pfam02151
65093003319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093003320	Walker A motif; other site
65093003321	ATP binding site [chemical binding]; other site
65093003322	Walker B motif; other site
65093003323	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65093003324	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
65093003325	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
65093003326	Probable Catalytic site; other site
65093003327	Protein of unknown function, DUF547; Region: DUF547; pfam04784
65093003328	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65093003329	active site residue [active]
65093003330	Predicted permeases [General function prediction only]; Region: COG0795
65093003331	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
65093003332	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
65093003333	HEAT repeats; Region: HEAT_2; pfam13646
65093003334	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65093003335	HEAT repeats; Region: HEAT_2; pfam13646
65093003336	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
65093003337	Part of AAA domain; Region: AAA_19; pfam13245
65093003338	Family description; Region: UvrD_C_2; pfam13538
65093003339	glycogen synthase; Provisional; Region: glgA; PRK00654
65093003340	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
65093003341	ADP-binding pocket [chemical binding]; other site
65093003342	homodimer interface [polypeptide binding]; other site
65093003343	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
65093003344	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
65093003345	G1 box; other site
65093003346	putative GEF interaction site [polypeptide binding]; other site
65093003347	GTP/Mg2+ binding site [chemical binding]; other site
65093003348	Switch I region; other site
65093003349	G2 box; other site
65093003350	G3 box; other site
65093003351	Switch II region; other site
65093003352	G4 box; other site
65093003353	G5 box; other site
65093003354	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
65093003355	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
65093003356	HEAT repeats; Region: HEAT_2; pfam13646
65093003357	HEAT repeats; Region: HEAT_2; pfam13646
65093003358	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093003359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003360	S-adenosylmethionine binding site [chemical binding]; other site
65093003361	ABC-2 type transporter; Region: ABC2_membrane; cl17235
65093003362	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
65093003363	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093003364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093003365	Walker A/P-loop; other site
65093003366	ATP binding site [chemical binding]; other site
65093003367	Q-loop/lid; other site
65093003368	ABC transporter signature motif; other site
65093003369	Walker B; other site
65093003370	D-loop; other site
65093003371	H-loop/switch region; other site
65093003372	4Fe-4S binding domain; Region: Fer4; pfam00037
65093003373	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65093003374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093003375	non-specific DNA binding site [nucleotide binding]; other site
65093003376	salt bridge; other site
65093003377	sequence-specific DNA binding site [nucleotide binding]; other site
65093003378	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65093003379	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
65093003380	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
65093003381	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093003382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093003383	homodimer interface [polypeptide binding]; other site
65093003384	catalytic residue [active]
65093003385	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65093003386	catalytic residues [active]
65093003387	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65093003388	nickel responsive regulator; Provisional; Region: PRK02967
65093003389	PemK-like protein; Region: PemK; pfam02452
65093003390	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
65093003391	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
65093003392	Na binding site [ion binding]; other site
65093003393	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65093003394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003395	binding surface
65093003396	TPR motif; other site
65093003397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003398	binding surface
65093003399	TPR motif; other site
65093003400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003401	binding surface
65093003402	TPR motif; other site
65093003403	Protein of unknown function (DUF563); Region: DUF563; pfam04577
65093003404	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003406	binding surface
65093003407	TPR motif; other site
65093003408	TPR repeat; Region: TPR_11; pfam13414
65093003409	TPR repeat; Region: TPR_11; pfam13414
65093003410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003411	binding surface
65093003412	TPR motif; other site
65093003413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003414	binding surface
65093003415	TPR motif; other site
65093003416	TPR repeat; Region: TPR_11; pfam13414
65093003417	TPR repeat; Region: TPR_11; pfam13414
65093003418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003419	binding surface
65093003420	TPR motif; other site
65093003421	TPR repeat; Region: TPR_11; pfam13414
65093003422	TPR repeat; Region: TPR_11; pfam13414
65093003423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003424	binding surface
65093003425	TPR motif; other site
65093003426	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093003428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003429	binding surface
65093003430	TPR repeat; Region: TPR_11; pfam13414
65093003431	TPR motif; other site
65093003432	TPR repeat; Region: TPR_11; pfam13414
65093003433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093003434	binding surface
65093003435	TPR motif; other site
65093003436	TPR repeat; Region: TPR_11; pfam13414
65093003437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093003438	binding surface
65093003439	TPR motif; other site
65093003440	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
65093003441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093003442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003443	binding surface
65093003444	TPR motif; other site
65093003445	TPR repeat; Region: TPR_11; pfam13414
65093003446	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093003447	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093003448	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
65093003449	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093003450	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093003451	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093003452	active site
65093003453	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65093003454	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65093003455	CHAT domain; Region: CHAT; cl17868
65093003456	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
65093003457	Aluminium resistance protein; Region: Alum_res; pfam06838
65093003458	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
65093003459	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65093003460	Di-iron ligands [ion binding]; other site
65093003461	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
65093003462	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
65093003463	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
65093003464	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
65093003465	dimer interface [polypeptide binding]; other site
65093003466	active site
65093003467	aspartate-rich active site metal binding site; other site
65093003468	allosteric magnesium binding site [ion binding]; other site
65093003469	Schiff base residues; other site
65093003470	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093003471	active site
65093003472	NTP binding site [chemical binding]; other site
65093003473	metal binding triad [ion binding]; metal-binding site
65093003474	antibiotic binding site [chemical binding]; other site
65093003475	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
65093003476	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
65093003477	Ligand Binding Site [chemical binding]; other site
65093003478	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
65093003479	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
65093003480	GIY-YIG motif/motif A; other site
65093003481	active site
65093003482	catalytic site [active]
65093003483	putative DNA binding site [nucleotide binding]; other site
65093003484	metal binding site [ion binding]; metal-binding site
65093003485	UvrB/uvrC motif; Region: UVR; pfam02151
65093003486	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
65093003487	Helix-hairpin-helix motif; Region: HHH; pfam00633
65093003488	TPR repeat; Region: TPR_11; pfam13414
65093003489	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003490	binding surface
65093003491	TPR motif; other site
65093003492	TPR repeat; Region: TPR_11; pfam13414
65093003493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003494	binding surface
65093003495	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003496	TPR motif; other site
65093003497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
65093003498	FIST N domain; Region: FIST; pfam08495
65093003499	FIST C domain; Region: FIST_C; pfam10442
65093003500	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
65093003501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003502	S-adenosylmethionine binding site [chemical binding]; other site
65093003503	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
65093003504	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
65093003505	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
65093003506	Probable Catalytic site; other site
65093003507	Tic20-like protein; Region: Tic20; pfam09685
65093003508	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65093003509	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65093003510	G1 box; other site
65093003511	GTP/Mg2+ binding site [chemical binding]; other site
65093003512	Switch I region; other site
65093003513	G2 box; other site
65093003514	Switch II region; other site
65093003515	G3 box; other site
65093003516	G4 box; other site
65093003517	G5 box; other site
65093003518	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65093003519	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
65093003520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093003521	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093003522	Probable transposase; Region: OrfB_IS605; pfam01385
65093003523	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093003524	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
65093003525	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
65093003526	active site
65093003527	dimer interface [polypeptide binding]; other site
65093003528	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
65093003529	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
65093003530	active site
65093003531	FMN binding site [chemical binding]; other site
65093003532	substrate binding site [chemical binding]; other site
65093003533	3Fe-4S cluster binding site [ion binding]; other site
65093003534	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
65093003535	domain interface; other site
65093003536	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
65093003537	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
65093003538	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093003539	Glycosyl hydrolase family 7; Region: GH7_CBH_EG; cd07999
65093003540	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
65093003541	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
65093003542	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093003543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003544	S-adenosylmethionine binding site [chemical binding]; other site
65093003545	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
65093003546	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093003547	active site
65093003548	motif I; other site
65093003549	motif II; other site
65093003550	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
65093003551	Family description; Region: UvrD_C_2; pfam13538
65093003552	CHAT domain; Region: CHAT; cl17868
65093003553	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
65093003554	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
65093003555	TPP-binding site [chemical binding]; other site
65093003556	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
65093003557	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093003558	putative active site [active]
65093003559	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093003560	Switch II region; other site
65093003561	G4 box; other site
65093003562	G5 box; other site
65093003563	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65093003564	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093003565	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
65093003566	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
65093003567	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
65093003568	nickel binding site [ion binding]; other site
65093003569	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
65093003570	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65093003571	P loop; other site
65093003572	Nucleotide binding site [chemical binding]; other site
65093003573	DTAP/Switch II; other site
65093003574	Switch I; other site
65093003575	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
65093003576	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65093003577	DTAP/Switch II; other site
65093003578	Switch I; other site
65093003579	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
65093003580	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
65093003581	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
65093003582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093003583	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093003584	Probable transposase; Region: OrfB_IS605; pfam01385
65093003585	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093003586	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
65093003587	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
65093003588	putative active site [active]
65093003589	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
65093003590	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093003591	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093003592	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
65093003593	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
65093003594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003595	binding surface
65093003596	TPR motif; other site
65093003597	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
65093003598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003599	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093003600	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093003601	sulfotransferase; Region: PLN02164
65093003602	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093003604	TPR motif; other site
65093003605	O-Antigen ligase; Region: Wzy_C; cl04850
65093003606	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
65093003607	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
65093003608	toxin interface [polypeptide binding]; other site
65093003609	Zn binding site [ion binding]; other site
65093003610	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
65093003611	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
65093003612	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
65093003613	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093003614	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
65093003615	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093003616	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65093003617	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
65093003618	PemK-like protein; Region: PemK; pfam02452
65093003619	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65093003620	oligomeric interface; other site
65093003621	putative active site [active]
65093003622	homodimer interface [polypeptide binding]; other site
65093003623	O-Antigen ligase; Region: Wzy_C; pfam04932
65093003624	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
65093003625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093003626	ATP binding site [chemical binding]; other site
65093003627	putative Mg++ binding site [ion binding]; other site
65093003628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093003629	nucleotide binding region [chemical binding]; other site
65093003630	ATP-binding site [chemical binding]; other site
65093003631	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
65093003632	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
65093003633	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
65093003634	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
65093003635	cytochrome b subunit interaction site [polypeptide binding]; other site
65093003636	[2Fe-2S] cluster binding site [ion binding]; other site
65093003637	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
65093003638	High-affinity nickel-transport protein; Region: NicO; cl00964
65093003639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003640	S-adenosylmethionine binding site [chemical binding]; other site
65093003641	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
65093003642	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
65093003643	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
65093003644	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
65093003645	putative active site [active]
65093003646	homotetrameric interface [polypeptide binding]; other site
65093003647	metal binding site [ion binding]; metal-binding site
65093003648	CRISPR-associated protein; Region: DUF3692; pfam12469
65093003649	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
65093003650	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
65093003651	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748
65093003652	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
65093003653	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65093003654	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
65093003655	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
65093003656	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
65093003657	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
65093003658	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
65093003659	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
65093003660	AAA domain; Region: AAA_33; pfam13671
65093003661	AAA domain; Region: AAA_17; pfam13207
65093003662	WYL domain; Region: WYL; pfam13280
65093003663	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093003664	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65093003665	active site
65093003666	catalytic tetrad [active]
65093003667	ferrochelatase; Reviewed; Region: hemH; PRK00035
65093003668	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
65093003669	active site
65093003670	C-terminal domain interface [polypeptide binding]; other site
65093003671	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
65093003672	active site
65093003673	N-terminal domain interface [polypeptide binding]; other site
65093003674	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
65093003675	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
65093003676	metal-binding site [ion binding]
65093003677	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
65093003678	putative active site pocket [active]
65093003679	dimerization interface [polypeptide binding]; other site
65093003680	putative catalytic residue [active]
65093003681	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
65093003682	active site
65093003683	Ribosomal L38e protein family; Region: Ribosomal_L38e; cl03352
65093003684	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
65093003685	MoaE interaction surface [polypeptide binding]; other site
65093003686	MoeB interaction surface [polypeptide binding]; other site
65093003687	thiocarboxylated glycine; other site
65093003688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
65093003689	O-Antigen ligase; Region: Wzy_C; pfam04932
65093003690	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093003691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093003692	active site
65093003693	phosphorylation site [posttranslational modification]
65093003694	intermolecular recognition site; other site
65093003695	dimerization interface [polypeptide binding]; other site
65093003696	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093003697	DNA binding residues [nucleotide binding]
65093003698	dimerization interface [polypeptide binding]; other site
65093003699	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65093003700	dimer interface [polypeptide binding]; other site
65093003701	[2Fe-2S] cluster binding site [ion binding]; other site
65093003702	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
65093003703	oligomerisation interface [polypeptide binding]; other site
65093003704	mobile loop; other site
65093003705	roof hairpin; other site
65093003706	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
65093003707	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
65093003708	ring oligomerisation interface [polypeptide binding]; other site
65093003709	ATP/Mg binding site [chemical binding]; other site
65093003710	stacking interactions; other site
65093003711	hinge regions; other site
65093003712	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
65093003713	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
65093003714	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
65093003715	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
65093003716	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
65093003717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093003718	FeS/SAM binding site; other site
65093003719	TRAM domain; Region: TRAM; pfam01938
65093003720	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093003721	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093003722	TAP-like protein; Region: Abhydrolase_4; pfam08386
65093003723	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
65093003724	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
65093003725	active site
65093003726	motif I; other site
65093003727	motif II; other site
65093003728	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
65093003729	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
65093003730	Walker A/P-loop; other site
65093003731	ATP binding site [chemical binding]; other site
65093003732	Q-loop/lid; other site
65093003733	ABC transporter signature motif; other site
65093003734	Walker B; other site
65093003735	D-loop; other site
65093003736	H-loop/switch region; other site
65093003737	mce related protein; Region: MCE; pfam02470
65093003738	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
65093003739	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093003740	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65093003741	putative switch regulator; other site
65093003742	non-specific DNA interactions [nucleotide binding]; other site
65093003743	DNA binding site [nucleotide binding]
65093003744	sequence specific DNA binding site [nucleotide binding]; other site
65093003745	putative cAMP binding site [chemical binding]; other site
65093003746	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
65093003747	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
65093003748	NAD binding site [chemical binding]; other site
65093003749	substrate binding site [chemical binding]; other site
65093003750	homodimer interface [polypeptide binding]; other site
65093003751	active site
65093003752	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
65093003753	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
65093003754	elongation factor Tu; Region: tufA; CHL00071
65093003755	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
65093003756	G1 box; other site
65093003757	GEF interaction site [polypeptide binding]; other site
65093003758	GTP/Mg2+ binding site [chemical binding]; other site
65093003759	Switch I region; other site
65093003760	G2 box; other site
65093003761	G3 box; other site
65093003762	Switch II region; other site
65093003763	G4 box; other site
65093003764	G5 box; other site
65093003765	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
65093003766	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
65093003767	Antibiotic Binding Site [chemical binding]; other site
65093003768	elongation factor G; Reviewed; Region: PRK00007
65093003769	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
65093003770	G1 box; other site
65093003771	putative GEF interaction site [polypeptide binding]; other site
65093003772	GTP/Mg2+ binding site [chemical binding]; other site
65093003773	Switch I region; other site
65093003774	G2 box; other site
65093003775	G3 box; other site
65093003776	Switch II region; other site
65093003777	G4 box; other site
65093003778	G5 box; other site
65093003779	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
65093003780	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
65093003781	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
65093003782	30S ribosomal protein S7; Validated; Region: PRK05302
65093003783	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
65093003784	S17 interaction site [polypeptide binding]; other site
65093003785	S8 interaction site; other site
65093003786	16S rRNA interaction site [nucleotide binding]; other site
65093003787	streptomycin interaction site [chemical binding]; other site
65093003788	23S rRNA interaction site [nucleotide binding]; other site
65093003789	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
65093003790	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
65093003791	Cupin domain; Region: Cupin_2; cl17218
65093003792	hypothetical protein; Validated; Region: PRK00110
65093003793	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
65093003794	lipoyl attachment site [posttranslational modification]; other site
65093003795	glycine dehydrogenase; Provisional; Region: PRK05367
65093003796	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
65093003797	tetramer interface [polypeptide binding]; other site
65093003798	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093003799	catalytic residue [active]
65093003800	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
65093003801	tetramer interface [polypeptide binding]; other site
65093003802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093003803	catalytic residue [active]
65093003804	T5orf172 domain; Region: T5orf172; pfam10544
65093003805	XisI protein; Region: XisI; pfam08869
65093003806	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093003807	YcfA-like protein; Region: YcfA; cl00752
65093003808	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
65093003809	dimer interface [polypeptide binding]; other site
65093003810	RNA polymerase sigma factor; Provisional; Region: PRK12518
65093003811	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093003812	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093003813	DNA binding residues [nucleotide binding]
65093003814	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
65093003815	catalytic site [active]
65093003816	putative active site [active]
65093003817	putative substrate binding site [chemical binding]; other site
65093003818	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
65093003819	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
65093003820	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
65093003821	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
65093003822	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
65093003823	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
65093003824	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
65093003825	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093003826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003827	S-adenosylmethionine binding site [chemical binding]; other site
65093003828	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
65093003829	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093003830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093003831	binding surface
65093003832	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003833	TPR motif; other site
65093003834	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093003835	16S rRNA methyltransferase B; Provisional; Region: PRK14901
65093003836	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
65093003837	putative RNA binding site [nucleotide binding]; other site
65093003838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003839	S-adenosylmethionine binding site [chemical binding]; other site
65093003840	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
65093003841	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
65093003842	dimer interface [polypeptide binding]; other site
65093003843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093003844	catalytic residue [active]
65093003845	Probable transposase; Region: OrfB_IS605; pfam01385
65093003846	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093003847	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093003848	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65093003849	DNA binding residues [nucleotide binding]
65093003850	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65093003851	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
65093003852	catalytic residues [active]
65093003853	catalytic nucleophile [active]
65093003854	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
65093003855	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
65093003856	active site
65093003857	PHP Thumb interface [polypeptide binding]; other site
65093003858	metal binding site [ion binding]; metal-binding site
65093003859	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093003860	protein-splicing catalytic site; other site
65093003861	thioester formation/cholesterol transfer; other site
65093003862	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093003863	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093003864	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093003865	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
65093003866	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
65093003867	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
65093003868	HEAT repeats; Region: HEAT_2; pfam13646
65093003869	HEAT repeats; Region: HEAT_2; pfam13646
65093003870	Transcriptional regulator [Transcription]; Region: LysR; COG0583
65093003871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65093003872	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
65093003873	dimerization interface [polypeptide binding]; other site
65093003874	hypothetical protein; Provisional; Region: PRK07394
65093003875	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
65093003876	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
65093003877	Bacterial TniB protein; Region: TniB; pfam05621
65093003878	AAA domain; Region: AAA_22; pfam13401
65093003879	TniQ; Region: TniQ; pfam06527
65093003880	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
65093003881	Divergent AAA domain; Region: AAA_4; pfam04326
65093003882	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
65093003883	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093003884	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
65093003885	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
65093003886	putative active site [active]
65093003887	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65093003888	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65093003889	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65093003890	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
65093003891	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
65093003892	DNA binding residues [nucleotide binding]
65093003893	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
65093003894	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
65093003895	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093003896	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
65093003897	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
65093003898	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
65093003899	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
65093003900	arogenate dehydrogenase; Reviewed; Region: PRK07417
65093003901	prephenate dehydrogenase; Validated; Region: PRK08507
65093003902	LlaMI restriction endonuclease; Region: RE_LlaMI; pfam09562
65093003903	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093003904	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65093003905	cofactor binding site; other site
65093003906	DNA binding site [nucleotide binding]
65093003907	substrate interaction site [chemical binding]; other site
65093003908	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
65093003909	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
65093003910	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
65093003911	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
65093003912	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093003913	putative ADP-binding pocket [chemical binding]; other site
65093003914	MASE1; Region: MASE1; pfam05231
65093003915	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093003916	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093003917	metal binding site [ion binding]; metal-binding site
65093003918	active site
65093003919	I-site; other site
65093003920	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093003921	Protein of unknown function, DUF393; Region: DUF393; pfam04134
65093003922	EamA-like transporter family; Region: EamA; pfam00892
65093003923	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
65093003924	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
65093003925	acyl-activating enzyme (AAE) consensus motif; other site
65093003926	putative AMP binding site [chemical binding]; other site
65093003927	putative active site [active]
65093003928	putative CoA binding site [chemical binding]; other site
65093003929	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65093003930	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
65093003931	putative phosphoketolase; Provisional; Region: PRK05261
65093003932	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
65093003933	TPP-binding site; other site
65093003934	XFP C-terminal domain; Region: XFP_C; pfam09363
65093003935	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65093003936	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
65093003937	active site
65093003938	PUCC protein; Region: PUCC; pfam03209
65093003939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093003940	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
65093003941	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65093003942	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093003943	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65093003944	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65093003945	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65093003946	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093003947	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093003948	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
65093003949	Walker A/P-loop; other site
65093003950	ATP binding site [chemical binding]; other site
65093003951	Q-loop/lid; other site
65093003952	ABC transporter signature motif; other site
65093003953	Walker B; other site
65093003954	D-loop; other site
65093003955	H-loop/switch region; other site
65093003956	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093003957	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
65093003958	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
65093003959	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
65093003960	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
65093003961	tandem repeat interface [polypeptide binding]; other site
65093003962	oligomer interface [polypeptide binding]; other site
65093003963	active site residues [active]
65093003964	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
65093003965	tandem repeat interface [polypeptide binding]; other site
65093003966	oligomer interface [polypeptide binding]; other site
65093003967	active site residues [active]
65093003968	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
65093003969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093003970	dimer interface [polypeptide binding]; other site
65093003971	conserved gate region; other site
65093003972	putative PBP binding loops; other site
65093003973	ABC-ATPase subunit interface; other site
65093003974	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
65093003975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093003976	S-adenosylmethionine binding site [chemical binding]; other site
65093003977	GAF domain; Region: GAF; pfam01590
65093003978	Phytochrome region; Region: PHY; pfam00360
65093003979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093003980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093003981	metal binding site [ion binding]; metal-binding site
65093003982	active site
65093003983	I-site; other site
65093003984	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093003985	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093003986	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093003987	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093003988	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093003989	metal binding site [ion binding]; metal-binding site
65093003990	active site
65093003991	I-site; other site
65093003992	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65093003993	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093003994	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093003995	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65093003996	Predicted membrane protein [Function unknown]; Region: COG3431
65093003997	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65093003998	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093003999	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093004000	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65093004001	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
65093004002	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093004003	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
65093004004	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
65093004005	Walker A/P-loop; other site
65093004006	ATP binding site [chemical binding]; other site
65093004007	Q-loop/lid; other site
65093004008	ABC transporter signature motif; other site
65093004009	Walker B; other site
65093004010	D-loop; other site
65093004011	H-loop/switch region; other site
65093004012	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
65093004013	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
65093004014	Walker A/P-loop; other site
65093004015	ATP binding site [chemical binding]; other site
65093004016	Q-loop/lid; other site
65093004017	ABC transporter signature motif; other site
65093004018	Walker B; other site
65093004019	D-loop; other site
65093004020	H-loop/switch region; other site
65093004021	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
65093004022	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65093004023	TM-ABC transporter signature motif; other site
65093004024	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
65093004025	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
65093004026	TM-ABC transporter signature motif; other site
65093004027	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
65093004028	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
65093004029	ligand binding site [chemical binding]; other site
65093004030	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65093004031	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093004032	catalytic triad [active]
65093004033	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
65093004034	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
65093004035	N- and C-terminal domain interface [polypeptide binding]; other site
65093004036	active site
65093004037	MgATP binding site [chemical binding]; other site
65093004038	catalytic site [active]
65093004039	metal binding site [ion binding]; metal-binding site
65093004040	glycerol binding site [chemical binding]; other site
65093004041	homotetramer interface [polypeptide binding]; other site
65093004042	homodimer interface [polypeptide binding]; other site
65093004043	FBP binding site [chemical binding]; other site
65093004044	protein IIAGlc interface [polypeptide binding]; other site
65093004045	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
65093004046	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
65093004047	putative dimer interface [polypeptide binding]; other site
65093004048	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
65093004049	hypothetical protein; Provisional; Region: PRK02509
65093004050	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
65093004051	Uncharacterized conserved protein [Function unknown]; Region: COG1615
65093004052	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
65093004053	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65093004054	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
65093004055	putative C-terminal domain interface [polypeptide binding]; other site
65093004056	putative GSH binding site (G-site) [chemical binding]; other site
65093004057	putative dimer interface [polypeptide binding]; other site
65093004058	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65093004059	N-terminal domain interface [polypeptide binding]; other site
65093004060	dimer interface [polypeptide binding]; other site
65093004061	substrate binding pocket (H-site) [chemical binding]; other site
65093004062	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65093004063	Protein of unknown function, DUF393; Region: DUF393; pfam04134
65093004064	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
65093004065	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
65093004066	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093004067	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
65093004068	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
65093004069	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093004070	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
65093004071	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
65093004072	domain interfaces; other site
65093004073	active site
65093004074	phosphoenolpyruvate synthase; Validated; Region: PRK06464
65093004075	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65093004076	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65093004077	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65093004078	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
65093004079	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
65093004080	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
65093004081	dimer interface [polypeptide binding]; other site
65093004082	motif 1; other site
65093004083	active site
65093004084	motif 2; other site
65093004085	motif 3; other site
65093004086	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093004087	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093004088	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093004089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093004090	metal binding site [ion binding]; metal-binding site
65093004091	active site
65093004092	I-site; other site
65093004093	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
65093004094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093004095	S-adenosylmethionine binding site [chemical binding]; other site
65093004096	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
65093004097	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
65093004098	substrate binding site [chemical binding]; other site
65093004099	hexamer interface [polypeptide binding]; other site
65093004100	metal binding site [ion binding]; metal-binding site
65093004101	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
65093004102	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
65093004103	active site
65093004104	catalytic residues [active]
65093004105	Uncharacterized conserved protein [Function unknown]; Region: COG4279
65093004106	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
65093004107	putative active site [active]
65093004108	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
65093004109	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
65093004110	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
65093004111	ring oligomerisation interface [polypeptide binding]; other site
65093004112	ATP/Mg binding site [chemical binding]; other site
65093004113	stacking interactions; other site
65093004114	hinge regions; other site
65093004115	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093004116	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65093004117	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093004118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004119	active site
65093004120	phosphorylation site [posttranslational modification]
65093004121	intermolecular recognition site; other site
65093004122	dimerization interface [polypeptide binding]; other site
65093004123	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
65093004124	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
65093004125	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093004126	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
65093004127	putative ADP-binding pocket [chemical binding]; other site
65093004128	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093004129	Methyltransferase domain; Region: Methyltransf_11; pfam08241
65093004130	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
65093004131	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
65093004132	active site
65093004133	substrate binding site [chemical binding]; other site
65093004134	metal binding site [ion binding]; metal-binding site
65093004135	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
65093004136	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
65093004137	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
65093004138	dimer interface [polypeptide binding]; other site
65093004139	catalytic residues [active]
65093004140	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
65093004141	UreF; Region: UreF; pfam01730
65093004142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093004143	Coenzyme A binding pocket [chemical binding]; other site
65093004144	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093004145	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
65093004146	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
65093004147	alpha-gamma subunit interface [polypeptide binding]; other site
65093004148	beta-gamma subunit interface [polypeptide binding]; other site
65093004149	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
65093004150	gamma-beta subunit interface [polypeptide binding]; other site
65093004151	alpha-beta subunit interface [polypeptide binding]; other site
65093004152	urease subunit alpha; Reviewed; Region: ureC; PRK13207
65093004153	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
65093004154	subunit interactions [polypeptide binding]; other site
65093004155	active site
65093004156	flap region; other site
65093004157	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65093004158	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
65093004159	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
65093004160	RimK-like ATP-grasp domain; Region: RimK; pfam08443
65093004161	Predicted deacylase [General function prediction only]; Region: COG3608
65093004162	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
65093004163	putative active site [active]
65093004164	Zn binding site [ion binding]; other site
65093004165	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
65093004166	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
65093004167	active site
65093004168	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
65093004169	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
65093004170	dimer interface [polypeptide binding]; other site
65093004171	active site
65093004172	glycine-pyridoxal phosphate binding site [chemical binding]; other site
65093004173	folate binding site [chemical binding]; other site
65093004174	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
65093004175	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
65093004176	Mg++ binding site [ion binding]; other site
65093004177	putative catalytic motif [active]
65093004178	substrate binding site [chemical binding]; other site
65093004179	competence damage-inducible protein A; Provisional; Region: PRK00549
65093004180	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
65093004181	putative MPT binding site; other site
65093004182	Competence-damaged protein; Region: CinA; pfam02464
65093004183	glutathione reductase; Validated; Region: PRK06116
65093004184	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093004185	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093004186	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65093004187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093004188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093004189	putative substrate translocation pore; other site
65093004190	HEAT repeats; Region: HEAT_2; pfam13646
65093004191	HEAT repeats; Region: HEAT_2; pfam13646
65093004192	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093004193	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093004194	ligand binding site [chemical binding]; other site
65093004195	flexible hinge region; other site
65093004196	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
65093004197	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
65093004198	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65093004199	active site
65093004200	Response regulator receiver domain; Region: Response_reg; pfam00072
65093004201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004202	active site
65093004203	phosphorylation site [posttranslational modification]
65093004204	intermolecular recognition site; other site
65093004205	dimerization interface [polypeptide binding]; other site
65093004206	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
65093004207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093004208	Walker A motif; other site
65093004209	ATP binding site [chemical binding]; other site
65093004210	Walker B motif; other site
65093004211	arginine finger; other site
65093004212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093004213	Walker A motif; other site
65093004214	ATP binding site [chemical binding]; other site
65093004215	Walker B motif; other site
65093004216	arginine finger; other site
65093004217	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
65093004218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093004219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093004220	DNA binding residues [nucleotide binding]
65093004221	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
65093004222	Putative zinc-finger; Region: zf-HC2; pfam13490
65093004223	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
65093004224	putative active site pocket [active]
65093004225	dimerization interface [polypeptide binding]; other site
65093004226	putative catalytic residue [active]
65093004227	phosphoribulokinase; Provisional; Region: PRK07429
65093004228	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093004229	active site
65093004230	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
65093004231	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
65093004232	FMN binding site [chemical binding]; other site
65093004233	active site
65093004234	catalytic residues [active]
65093004235	substrate binding site [chemical binding]; other site
65093004236	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093004237	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
65093004238	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65093004239	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65093004240	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093004241	Ligand Binding Site [chemical binding]; other site
65093004242	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093004243	Ligand Binding Site [chemical binding]; other site
65093004244	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
65093004245	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093004246	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65093004247	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65093004248	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093004249	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093004250	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
65093004251	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093004252	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093004253	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65093004254	catalytic site [active]
65093004255	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093004256	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
65093004257	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65093004258	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65093004259	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
65093004260	dimer interface [polypeptide binding]; other site
65093004261	decamer (pentamer of dimers) interface [polypeptide binding]; other site
65093004262	catalytic triad [active]
65093004263	peroxidatic and resolving cysteines [active]
65093004264	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
65093004265	pyrroline-5-carboxylate reductase; Region: PLN02688
65093004266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
65093004267	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
65093004268	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65093004269	catalytic residue [active]
65093004270	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
65093004271	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65093004272	classical (c) SDRs; Region: SDR_c; cd05233
65093004273	NAD(P) binding site [chemical binding]; other site
65093004274	active site
65093004275	short chain dehydrogenase; Provisional; Region: PRK08303
65093004276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093004277	NAD(P) binding site [chemical binding]; other site
65093004278	active site
65093004279	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
65093004280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093004281	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65093004282	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
65093004283	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
65093004284	dimer interface [polypeptide binding]; other site
65093004285	putative functional site; other site
65093004286	putative MPT binding site; other site
65093004287	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
65093004288	DNA photolyase; Region: DNA_photolyase; pfam00875
65093004289	S-layer homology domain; Region: SLH; pfam00395
65093004290	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65093004291	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65093004292	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65093004293	NAD(P) binding site [chemical binding]; other site
65093004294	putative active site [active]
65093004295	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
65093004296	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
65093004297	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
65093004298	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
65093004299	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
65093004300	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
65093004301	substrate binding site [chemical binding]; other site
65093004302	active site
65093004303	catalytic residues [active]
65093004304	heterodimer interface [polypeptide binding]; other site
65093004305	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
65093004306	active site
65093004307	catalytic residues [active]
65093004308	homoserine dehydrogenase; Provisional; Region: PRK06349
65093004309	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
65093004310	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
65093004311	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
65093004312	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
65093004313	polymerase nucleotide-binding site; other site
65093004314	DNA-binding residues [nucleotide binding]; DNA binding site
65093004315	nucleotide binding site [chemical binding]; other site
65093004316	primase nucleotide-binding site [nucleotide binding]; other site
65093004317	CHC2 zinc finger; Region: zf-CHC2; cl17510
65093004318	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
65093004319	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
65093004320	active site
65093004321	NTP binding site [chemical binding]; other site
65093004322	metal binding triad [ion binding]; metal-binding site
65093004323	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
65093004324	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
65093004325	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
65093004326	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65093004327	EamA-like transporter family; Region: EamA; pfam00892
65093004328	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093004329	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
65093004330	Peptidase family M50; Region: Peptidase_M50; pfam02163
65093004331	active site
65093004332	putative substrate binding region [chemical binding]; other site
65093004333	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
65093004334	SmpB-tmRNA interface; other site
65093004335	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
65093004336	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
65093004337	cytochrome c-550; Region: PS_II_C550; TIGR03045
65093004338	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65093004339	Cytochrome b562; Region: Cytochrom_B562; cl01546
65093004340	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
65093004341	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093004342	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093004343	active site
65093004344	ATP binding site [chemical binding]; other site
65093004345	substrate binding site [chemical binding]; other site
65093004346	activation loop (A-loop); other site
65093004347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093004348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093004349	metal binding site [ion binding]; metal-binding site
65093004350	active site
65093004351	I-site; other site
65093004352	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65093004353	D-xylulose kinase; Region: XylB; TIGR01312
65093004354	nucleotide binding site [chemical binding]; other site
65093004355	DNA methylase; Region: N6_N4_Mtase; cl17433
65093004356	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65093004357	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
65093004358	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
65093004359	active site
65093004360	dimer interface [polypeptide binding]; other site
65093004361	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
65093004362	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
65093004363	active site
65093004364	FMN binding site [chemical binding]; other site
65093004365	substrate binding site [chemical binding]; other site
65093004366	3Fe-4S cluster binding site [ion binding]; other site
65093004367	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
65093004368	domain interface; other site
65093004369	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
65093004370	active site
65093004371	NAD binding site [chemical binding]; other site
65093004372	metal binding site [ion binding]; metal-binding site
65093004373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093004374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093004375	putative substrate translocation pore; other site
65093004376	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65093004377	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65093004378	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093004379	FOG: CBS domain [General function prediction only]; Region: COG0517
65093004380	FOG: CBS domain [General function prediction only]; Region: COG0517
65093004381	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
65093004382	PAS domain S-box; Region: sensory_box; TIGR00229
65093004383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004384	putative active site [active]
65093004385	heme pocket [chemical binding]; other site
65093004386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093004387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093004388	dimer interface [polypeptide binding]; other site
65093004389	phosphorylation site [posttranslational modification]
65093004390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093004391	ATP binding site [chemical binding]; other site
65093004392	Mg2+ binding site [ion binding]; other site
65093004393	G-X-G motif; other site
65093004394	Response regulator receiver domain; Region: Response_reg; pfam00072
65093004395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004396	active site
65093004397	phosphorylation site [posttranslational modification]
65093004398	intermolecular recognition site; other site
65093004399	dimerization interface [polypeptide binding]; other site
65093004400	Response regulator receiver domain; Region: Response_reg; pfam00072
65093004401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004402	active site
65093004403	phosphorylation site [posttranslational modification]
65093004404	intermolecular recognition site; other site
65093004405	dimerization interface [polypeptide binding]; other site
65093004406	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093004407	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093004408	metal binding site [ion binding]; metal-binding site
65093004409	active site
65093004410	I-site; other site
65093004411	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093004412	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093004413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004414	active site
65093004415	phosphorylation site [posttranslational modification]
65093004416	intermolecular recognition site; other site
65093004417	dimerization interface [polypeptide binding]; other site
65093004418	Response regulator receiver domain; Region: Response_reg; pfam00072
65093004419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004420	active site
65093004421	phosphorylation site [posttranslational modification]
65093004422	intermolecular recognition site; other site
65093004423	dimerization interface [polypeptide binding]; other site
65093004424	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093004425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65093004426	Histidine kinase; Region: HisKA_2; pfam07568
65093004427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093004428	ATP binding site [chemical binding]; other site
65093004429	Mg2+ binding site [ion binding]; other site
65093004430	G-X-G motif; other site
65093004431	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
65093004432	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
65093004433	Cl- selectivity filter; other site
65093004434	Cl- binding residues [ion binding]; other site
65093004435	pore gating glutamate residue; other site
65093004436	dimer interface [polypeptide binding]; other site
65093004437	H+/Cl- coupling transport residue; other site
65093004438	FOG: CBS domain [General function prediction only]; Region: COG0517
65093004439	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
65093004440	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65093004441	Ligand Binding Site [chemical binding]; other site
65093004442	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093004443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093004444	Probable transposase; Region: OrfB_IS605; pfam01385
65093004445	septum formation inhibitor; Reviewed; Region: minC; PRK00513
65093004446	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
65093004447	septum site-determining protein MinD; Region: minD_bact; TIGR01968
65093004448	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
65093004449	Switch I; other site
65093004450	Switch II; other site
65093004451	cell division topological specificity factor MinE; Provisional; Region: PRK13988
65093004452	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
65093004453	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
65093004454	putative active site [active]
65093004455	putative dimer interface [polypeptide binding]; other site
65093004456	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
65093004457	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65093004458	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
65093004459	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
65093004460	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
65093004461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65093004462	Walker A/P-loop; other site
65093004463	ATP binding site [chemical binding]; other site
65093004464	Q-loop/lid; other site
65093004465	ABC transporter signature motif; other site
65093004466	Walker B; other site
65093004467	D-loop; other site
65093004468	H-loop/switch region; other site
65093004469	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
65093004470	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65093004471	Walker A/P-loop; other site
65093004472	ATP binding site [chemical binding]; other site
65093004473	Q-loop/lid; other site
65093004474	ABC transporter signature motif; other site
65093004475	Walker B; other site
65093004476	D-loop; other site
65093004477	H-loop/switch region; other site
65093004478	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
65093004479	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
65093004480	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65093004481	Zn2+ binding site [ion binding]; other site
65093004482	Mg2+ binding site [ion binding]; other site
65093004483	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
65093004484	synthetase active site [active]
65093004485	NTP binding site [chemical binding]; other site
65093004486	metal binding site [ion binding]; metal-binding site
65093004487	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
65093004488	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
65093004489	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
65093004490	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093004491	chorismate binding enzyme; Region: Chorismate_bind; cl10555
65093004492	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
65093004493	catalytic triad [active]
65093004494	conserved cis-peptide bond; other site
65093004495	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004496	putative active site [active]
65093004497	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004498	putative active site [active]
65093004499	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
65093004500	ATP-sulfurylase; Region: ATPS; cd00517
65093004501	active site
65093004502	HXXH motif; other site
65093004503	flexible loop; other site
65093004504	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004505	putative active site [active]
65093004506	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65093004507	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65093004508	protein binding site [polypeptide binding]; other site
65093004509	Sensors of blue-light using FAD; Region: BLUF; pfam04940
65093004510	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
65093004511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093004512	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
65093004513	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
65093004514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093004515	ornithine carbamoyltransferase; Provisional; Region: PRK00779
65093004516	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
65093004517	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
65093004518	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
65093004519	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
65093004520	active site
65093004521	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65093004522	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
65093004523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093004524	Probable transposase; Region: OrfB_IS605; pfam01385
65093004525	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093004526	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65093004527	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
65093004528	putative ligand binding site [chemical binding]; other site
65093004529	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
65093004530	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
65093004531	Flavoprotein; Region: Flavoprotein; pfam02441
65093004532	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
65093004533	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
65093004534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093004535	dimer interface [polypeptide binding]; other site
65093004536	conserved gate region; other site
65093004537	putative PBP binding loops; other site
65093004538	ABC-ATPase subunit interface; other site
65093004539	excinuclease ABC subunit B; Provisional; Region: PRK05298
65093004540	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093004541	ATP binding site [chemical binding]; other site
65093004542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093004543	nucleotide binding region [chemical binding]; other site
65093004544	ATP-binding site [chemical binding]; other site
65093004545	Ultra-violet resistance protein B; Region: UvrB; pfam12344
65093004546	UvrB/uvrC motif; Region: UVR; pfam02151
65093004547	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
65093004548	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
65093004549	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
65093004550	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093004551	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
65093004552	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65093004553	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093004554	Walker A/P-loop; other site
65093004555	ATP binding site [chemical binding]; other site
65093004556	Q-loop/lid; other site
65093004557	ABC transporter signature motif; other site
65093004558	Walker B; other site
65093004559	D-loop; other site
65093004560	H-loop/switch region; other site
65093004561	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093004562	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65093004563	Walker A/P-loop; other site
65093004564	ATP binding site [chemical binding]; other site
65093004565	Q-loop/lid; other site
65093004566	ABC transporter signature motif; other site
65093004567	Walker B; other site
65093004568	D-loop; other site
65093004569	H-loop/switch region; other site
65093004570	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
65093004571	Na binding site [ion binding]; other site
65093004572	hypothetical protein; Provisional; Region: PRK10279
65093004573	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
65093004574	active site
65093004575	nucleophile elbow; other site
65093004576	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093004577	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093004578	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
65093004579	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
65093004580	dimer interface [polypeptide binding]; other site
65093004581	motif 1; other site
65093004582	active site
65093004583	motif 2; other site
65093004584	motif 3; other site
65093004585	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
65093004586	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
65093004587	active site
65093004588	homodimer interface [polypeptide binding]; other site
65093004589	acylphosphatase; Provisional; Region: PRK14423
65093004590	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
65093004591	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093004592	active site
65093004593	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65093004594	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
65093004595	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
65093004596	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
65093004597	YceG-like family; Region: YceG; pfam02618
65093004598	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
65093004599	dimerization interface [polypeptide binding]; other site
65093004600	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093004601	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65093004602	Hexamer interface [polypeptide binding]; other site
65093004603	Hexagonal pore residue; other site
65093004604	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65093004605	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093004606	Hexamer interface [polypeptide binding]; other site
65093004607	Hexagonal pore residue; other site
65093004608	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65093004609	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65093004610	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
65093004611	putative active site [active]
65093004612	putative NTP binding site [chemical binding]; other site
65093004613	putative nucleic acid binding site [nucleotide binding]; other site
65093004614	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
65093004615	Part of AAA domain; Region: AAA_19; pfam13245
65093004616	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
65093004617	active site
65093004618	catalytic site [active]
65093004619	substrate binding site [chemical binding]; other site
65093004620	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
65093004621	Family description; Region: UvrD_C_2; pfam13538
65093004622	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
65093004623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093004624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093004625	homodimer interface [polypeptide binding]; other site
65093004626	catalytic residue [active]
65093004627	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
65093004628	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
65093004629	glutaminase active site [active]
65093004630	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
65093004631	dimer interface [polypeptide binding]; other site
65093004632	active site
65093004633	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
65093004634	dimer interface [polypeptide binding]; other site
65093004635	active site
65093004636	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
65093004637	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
65093004638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093004639	ATP-binding site [chemical binding]; other site
65093004640	Ras GTPase Activating Domain; Region: RasGAP; cl02569
65093004641	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
65093004642	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093004643	active site
65093004644	NTP binding site [chemical binding]; other site
65093004645	metal binding triad [ion binding]; metal-binding site
65093004646	antibiotic binding site [chemical binding]; other site
65093004647	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
65093004648	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
65093004649	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
65093004650	G1 box; other site
65093004651	GTP/Mg2+ binding site [chemical binding]; other site
65093004652	Switch I region; other site
65093004653	G2 box; other site
65093004654	G3 box; other site
65093004655	Switch II region; other site
65093004656	G4 box; other site
65093004657	G5 box; other site
65093004658	Nucleoside recognition; Region: Gate; pfam07670
65093004659	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
65093004660	FeoA domain; Region: FeoA; pfam04023
65093004661	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
65093004662	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
65093004663	Ferritin-like domain; Region: Ferritin; pfam00210
65093004664	ferroxidase diiron center [ion binding]; other site
65093004665	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
65093004666	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
65093004667	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
65093004668	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
65093004669	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093004670	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
65093004671	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
65093004672	citrate synthase; Provisional; Region: PRK14036
65093004673	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
65093004674	dimer interface [polypeptide binding]; other site
65093004675	active site
65093004676	citrylCoA binding site [chemical binding]; other site
65093004677	oxalacetate/citrate binding site [chemical binding]; other site
65093004678	coenzyme A binding site [chemical binding]; other site
65093004679	catalytic triad [active]
65093004680	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
65093004681	phosphatidate cytidylyltransferase; Region: PLN02953
65093004682	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093004683	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093004684	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093004685	TrkA-N domain; Region: TrkA_N; pfam02254
65093004686	Protein of unknown function (DUF1012); Region: DUF1012; pfam06241
65093004687	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
65093004688	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65093004689	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
65093004690	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
65093004691	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
65093004692	protein binding site [polypeptide binding]; other site
65093004693	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004694	putative active site [active]
65093004695	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093004696	YcfA-like protein; Region: YcfA; pfam07927
65093004697	Putative addiction module component; Region: Unstab_antitox; cl09921
65093004698	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093004699	YcfA-like protein; Region: YcfA; pfam07927
65093004700	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
65093004701	diiron binding motif [ion binding]; other site
65093004702	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
65093004703	heme binding pocket [chemical binding]; other site
65093004704	heme ligand [chemical binding]; other site
65093004705	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
65093004706	HemN C-terminal domain; Region: HemN_C; pfam06969
65093004707	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65093004708	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
65093004709	metal-binding site [ion binding]
65093004710	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093004711	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65093004712	FtsI repressor; Provisional; Region: PRK10883
65093004713	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
65093004714	Multicopper oxidase; Region: Cu-oxidase; pfam00394
65093004715	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
65093004716	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004717	putative active site [active]
65093004718	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
65093004719	DNA binding residues [nucleotide binding]
65093004720	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
65093004721	dimer interface [polypeptide binding]; other site
65093004722	metal binding site [ion binding]; metal-binding site
65093004723	Predicted metal-binding protein [General function prediction only]; Region: COG3019
65093004724	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093004725	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093004726	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093004727	YtkA-like; Region: YtkA; pfam13115
65093004728	YtkA-like; Region: YtkA; pfam13115
65093004729	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
65093004730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093004731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004732	active site
65093004733	phosphorylation site [posttranslational modification]
65093004734	intermolecular recognition site; other site
65093004735	dimerization interface [polypeptide binding]; other site
65093004736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093004737	DNA binding site [nucleotide binding]
65093004738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093004739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093004740	dimer interface [polypeptide binding]; other site
65093004741	phosphorylation site [posttranslational modification]
65093004742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093004743	ATP binding site [chemical binding]; other site
65093004744	Mg2+ binding site [ion binding]; other site
65093004745	G-X-G motif; other site
65093004746	Cation efflux family; Region: Cation_efflux; cl00316
65093004747	Cache domain; Region: Cache_1; pfam02743
65093004748	PAS fold; Region: PAS_4; pfam08448
65093004749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004750	putative active site [active]
65093004751	heme pocket [chemical binding]; other site
65093004752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093004753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093004754	metal binding site [ion binding]; metal-binding site
65093004755	active site
65093004756	I-site; other site
65093004757	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
65093004758	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
65093004759	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
65093004760	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093004761	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
65093004762	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
65093004763	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093004764	Putative transcription activator [Transcription]; Region: TenA; COG0819
65093004765	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
65093004766	GSH binding site [chemical binding]; other site
65093004767	catalytic residues [active]
65093004768	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093004769	dimerization interface [polypeptide binding]; other site
65093004770	PAS fold; Region: PAS; pfam00989
65093004771	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004772	putative active site [active]
65093004773	heme pocket [chemical binding]; other site
65093004774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093004775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093004776	dimer interface [polypeptide binding]; other site
65093004777	phosphorylation site [posttranslational modification]
65093004778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093004779	ATP binding site [chemical binding]; other site
65093004780	Mg2+ binding site [ion binding]; other site
65093004781	G-X-G motif; other site
65093004782	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093004783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004784	active site
65093004785	phosphorylation site [posttranslational modification]
65093004786	dimerization interface [polypeptide binding]; other site
65093004787	FOG: CBS domain [General function prediction only]; Region: COG0517
65093004788	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093004789	FOG: CBS domain [General function prediction only]; Region: COG0517
65093004790	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
65093004791	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093004792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004793	putative active site [active]
65093004794	heme pocket [chemical binding]; other site
65093004795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004796	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093004797	putative active site [active]
65093004798	heme pocket [chemical binding]; other site
65093004799	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004800	putative active site [active]
65093004801	heme pocket [chemical binding]; other site
65093004802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004803	PAS fold; Region: PAS_3; pfam08447
65093004804	putative active site [active]
65093004805	heme pocket [chemical binding]; other site
65093004806	PAS fold; Region: PAS_4; pfam08448
65093004807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093004808	putative active site [active]
65093004809	heme pocket [chemical binding]; other site
65093004810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093004811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093004812	dimer interface [polypeptide binding]; other site
65093004813	phosphorylation site [posttranslational modification]
65093004814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093004815	ATP binding site [chemical binding]; other site
65093004816	Mg2+ binding site [ion binding]; other site
65093004817	G-X-G motif; other site
65093004818	Response regulator receiver domain; Region: Response_reg; pfam00072
65093004819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093004820	active site
65093004821	phosphorylation site [posttranslational modification]
65093004822	intermolecular recognition site; other site
65093004823	dimerization interface [polypeptide binding]; other site
65093004824	glutathione synthetase; Provisional; Region: PRK05246
65093004825	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
65093004826	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
65093004827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
65093004828	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
65093004829	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
65093004830	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65093004831	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65093004832	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
65093004833	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
65093004834	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65093004835	putative ADP-binding pocket [chemical binding]; other site
65093004836	aspartate aminotransferase; Provisional; Region: PRK05764
65093004837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093004838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093004839	homodimer interface [polypeptide binding]; other site
65093004840	catalytic residue [active]
65093004841	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
65093004842	ligand binding site [chemical binding]; other site
65093004843	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
65093004844	tartrate dehydrogenase; Region: TTC; TIGR02089
65093004845	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
65093004846	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
65093004847	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65093004848	Walker A/P-loop; other site
65093004849	ATP binding site [chemical binding]; other site
65093004850	Q-loop/lid; other site
65093004851	ABC transporter signature motif; other site
65093004852	Walker B; other site
65093004853	D-loop; other site
65093004854	H-loop/switch region; other site
65093004855	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
65093004856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093004857	dimer interface [polypeptide binding]; other site
65093004858	conserved gate region; other site
65093004859	putative PBP binding loops; other site
65093004860	ABC-ATPase subunit interface; other site
65093004861	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
65093004862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093004863	dimer interface [polypeptide binding]; other site
65093004864	conserved gate region; other site
65093004865	putative PBP binding loops; other site
65093004866	ABC-ATPase subunit interface; other site
65093004867	PBP superfamily domain; Region: PBP_like_2; cl17296
65093004868	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
65093004869	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
65093004870	Walker A/P-loop; other site
65093004871	ATP binding site [chemical binding]; other site
65093004872	Q-loop/lid; other site
65093004873	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
65093004874	ABC transporter signature motif; other site
65093004875	Walker B; other site
65093004876	D-loop; other site
65093004877	H-loop/switch region; other site
65093004878	amidophosphoribosyltransferase; Provisional; Region: PRK07349
65093004879	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
65093004880	active site
65093004881	tetramer interface [polypeptide binding]; other site
65093004882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093004883	active site
65093004884	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093004885	putative active site [active]
65093004886	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
65093004887	Protein of unknown function DUF58; Region: DUF58; pfam01882
65093004888	intracellular protease, PfpI family; Region: PfpI; TIGR01382
65093004889	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
65093004890	conserved cys residue [active]
65093004891	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65093004892	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65093004893	WHG domain; Region: WHG; pfam13305
65093004894	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65093004895	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65093004896	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
65093004897	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093004898	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093004899	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093004900	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
65093004901	Protein export membrane protein; Region: SecD_SecF; cl14618
65093004902	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
65093004903	dimer interface [polypeptide binding]; other site
65093004904	putative tRNA-binding site [nucleotide binding]; other site
65093004905	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
65093004906	MutS domain III; Region: MutS_III; pfam05192
65093004907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093004908	Walker A/P-loop; other site
65093004909	ATP binding site [chemical binding]; other site
65093004910	Q-loop/lid; other site
65093004911	ABC transporter signature motif; other site
65093004912	Walker B; other site
65093004913	D-loop; other site
65093004914	H-loop/switch region; other site
65093004915	Smr domain; Region: Smr; pfam01713
65093004916	calcium/proton exchanger (cax); Region: cax; TIGR00378
65093004917	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65093004918	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65093004919	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
65093004920	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
65093004921	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
65093004922	active site
65093004923	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093004924	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65093004925	Walker A/P-loop; other site
65093004926	ATP binding site [chemical binding]; other site
65093004927	Q-loop/lid; other site
65093004928	ABC transporter signature motif; other site
65093004929	Walker B; other site
65093004930	D-loop; other site
65093004931	H-loop/switch region; other site
65093004932	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
65093004933	active site 1 [active]
65093004934	dimer interface [polypeptide binding]; other site
65093004935	hexamer interface [polypeptide binding]; other site
65093004936	active site 2 [active]
65093004937	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65093004938	dimer interface [polypeptide binding]; other site
65093004939	[2Fe-2S] cluster binding site [ion binding]; other site
65093004940	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
65093004941	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
65093004942	dimer interface [polypeptide binding]; other site
65093004943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093004944	catalytic residue [active]
65093004945	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
65093004946	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
65093004947	NifT/FixU protein; Region: NifT; pfam06988
65093004948	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
65093004949	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
65093004950	active site
65093004951	catalytic residues [active]
65093004952	metal binding site [ion binding]; metal-binding site
65093004953	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65093004954	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65093004955	dimerization interface [polypeptide binding]; other site
65093004956	DPS ferroxidase diiron center [ion binding]; other site
65093004957	ion pore; other site
65093004958	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
65093004959	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
65093004960	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
65093004961	trimer interface [polypeptide binding]; other site
65093004962	active site
65093004963	substrate binding site [chemical binding]; other site
65093004964	CoA binding site [chemical binding]; other site
65093004965	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
65093004966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093004967	FeS/SAM binding site; other site
65093004968	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
65093004969	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093004970	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65093004971	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
65093004972	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65093004973	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093004974	catalytic residue [active]
65093004975	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
65093004976	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
65093004977	trimerization site [polypeptide binding]; other site
65093004978	active site
65093004979	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
65093004980	NifU-like domain; Region: NifU; pfam01106
65093004981	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
65093004982	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
65093004983	Nucleotide-binding sites [chemical binding]; other site
65093004984	Walker A motif; other site
65093004985	Switch I region of nucleotide binding site; other site
65093004986	Fe4S4 binding sites [ion binding]; other site
65093004987	Switch II region of nucleotide binding site; other site
65093004988	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
65093004989	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
65093004990	MoFe protein alpha/beta subunit interactions; other site
65093004991	Alpha subunit P cluster binding residues; other site
65093004992	FeMoco binding residues [chemical binding]; other site
65093004993	MoFe protein alpha subunit/Fe protein contacts; other site
65093004994	MoFe protein dimer/ dimer interactions; other site
65093004995	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
65093004996	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
65093004997	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
65093004998	MoFe protein beta/alpha subunit interactions; other site
65093004999	Beta subunit P cluster binding residues; other site
65093005000	MoFe protein beta subunit/Fe protein contacts; other site
65093005001	MoFe protein dimer/ dimer interactions; other site
65093005002	NifZ domain; Region: NifZ; pfam04319
65093005003	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
65093005004	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
65093005005	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
65093005006	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
65093005007	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
65093005008	Protein of unknown function, DUF269; Region: DUF269; pfam03270
65093005009	Rop-like; Region: Rop-like; pfam05082
65093005010	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
65093005011	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
65093005012	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
65093005013	ATP binding site [chemical binding]; other site
65093005014	substrate interface [chemical binding]; other site
65093005015	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
65093005016	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093005017	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093005018	catalytic loop [active]
65093005019	iron binding site [ion binding]; other site
65093005020	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65093005021	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
65093005022	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
65093005023	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
65093005024	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
65093005025	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65093005026	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093005027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005028	S-adenosylmethionine binding site [chemical binding]; other site
65093005029	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
65093005030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093005031	dimer interface [polypeptide binding]; other site
65093005032	conserved gate region; other site
65093005033	putative PBP binding loops; other site
65093005034	ABC-ATPase subunit interface; other site
65093005035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093005036	Walker A/P-loop; other site
65093005037	ATP binding site [chemical binding]; other site
65093005038	ABC transporter; Region: ABC_tran; pfam00005
65093005039	Q-loop/lid; other site
65093005040	ABC transporter signature motif; other site
65093005041	Walker B; other site
65093005042	D-loop; other site
65093005043	H-loop/switch region; other site
65093005044	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
65093005045	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
65093005046	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
65093005047	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
65093005048	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
65093005049	Nuclease-related domain; Region: NERD; pfam08378
65093005050	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
65093005051	Family description; Region: UvrD_C_2; pfam13538
65093005052	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093005053	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093005054	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093005055	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093005056	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093005057	Ligand Binding Site [chemical binding]; other site
65093005058	Predicted integral membrane protein [Function unknown]; Region: COG0762
65093005059	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
65093005060	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
65093005061	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65093005062	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
65093005063	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65093005064	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65093005065	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65093005066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
65093005067	phosphorylation site [posttranslational modification]
65093005068	intermolecular recognition site; other site
65093005069	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093005070	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
65093005071	putative active site [active]
65093005072	putative metal binding site [ion binding]; other site
65093005073	Clp protease ATP binding subunit; Region: clpC; CHL00095
65093005074	Clp amino terminal domain; Region: Clp_N; pfam02861
65093005075	Clp amino terminal domain; Region: Clp_N; pfam02861
65093005076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093005077	Walker A motif; other site
65093005078	ATP binding site [chemical binding]; other site
65093005079	Walker B motif; other site
65093005080	arginine finger; other site
65093005081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093005082	Walker A motif; other site
65093005083	ATP binding site [chemical binding]; other site
65093005084	Walker B motif; other site
65093005085	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65093005086	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
65093005087	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
65093005088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65093005089	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65093005090	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093005091	Ligand Binding Site [chemical binding]; other site
65093005092	ferredoxin-sulfite reductase; Region: sir; TIGR02042
65093005093	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65093005094	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65093005095	ParG; Region: ParG; pfam09274
65093005096	Predicted membrane protein [Function unknown]; Region: COG1971
65093005097	Domain of unknown function DUF; Region: DUF204; pfam02659
65093005098	Domain of unknown function DUF; Region: DUF204; pfam02659
65093005099	C factor cell-cell signaling protein; Provisional; Region: PRK09009
65093005100	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
65093005101	NADP binding site [chemical binding]; other site
65093005102	homodimer interface [polypeptide binding]; other site
65093005103	active site
65093005104	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
65093005105	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65093005106	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093005107	catalytic residue [active]
65093005108	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
65093005109	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
65093005110	putative NADP binding site [chemical binding]; other site
65093005111	putative substrate binding site [chemical binding]; other site
65093005112	active site
65093005113	Response regulator receiver domain; Region: Response_reg; pfam00072
65093005114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093005115	active site
65093005116	phosphorylation site [posttranslational modification]
65093005117	intermolecular recognition site; other site
65093005118	dimerization interface [polypeptide binding]; other site
65093005119	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093005120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093005121	active site
65093005122	phosphorylation site [posttranslational modification]
65093005123	intermolecular recognition site; other site
65093005124	dimerization interface [polypeptide binding]; other site
65093005125	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093005126	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093005127	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093005128	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093005129	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093005130	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093005131	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093005132	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093005133	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093005134	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093005135	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093005136	dimer interface [polypeptide binding]; other site
65093005137	putative CheW interface [polypeptide binding]; other site
65093005138	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65093005139	oligomeric interface; other site
65093005140	putative active site [active]
65093005141	homodimer interface [polypeptide binding]; other site
65093005142	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093005143	putative binding surface; other site
65093005144	active site
65093005145	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093005146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093005147	ATP binding site [chemical binding]; other site
65093005148	Mg2+ binding site [ion binding]; other site
65093005149	G-X-G motif; other site
65093005150	Two component signalling adaptor domain; Region: CheW; smart00260
65093005151	Response regulator receiver domain; Region: Response_reg; pfam00072
65093005152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093005153	active site
65093005154	phosphorylation site [posttranslational modification]
65093005155	intermolecular recognition site; other site
65093005156	dimerization interface [polypeptide binding]; other site
65093005157	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
65093005158	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093005159	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
65093005160	PBP superfamily domain; Region: PBP_like_2; pfam12849
65093005161	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
65093005162	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
65093005163	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
65093005164	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
65093005165	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
65093005166	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65093005167	ABC1 family; Region: ABC1; pfam03109
65093005168	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65093005169	active site
65093005170	ATP binding site [chemical binding]; other site
65093005171	aspartate kinase; Provisional; Region: PRK07431
65093005172	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
65093005173	putative catalytic residues [active]
65093005174	putative nucleotide binding site [chemical binding]; other site
65093005175	putative aspartate binding site [chemical binding]; other site
65093005176	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
65093005177	putative allosteric regulatory site; other site
65093005178	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
65093005179	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
65093005180	putative allosteric regulatory site; other site
65093005181	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
65093005182	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
65093005183	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
65093005184	active site
65093005185	Zn binding site [ion binding]; other site
65093005186	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093005187	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65093005188	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65093005189	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
65093005190	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
65093005191	Protein of unknown function (DUF512); Region: DUF512; pfam04459
65093005192	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
65093005193	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093005194	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093005195	catalytic loop [active]
65093005196	iron binding site [ion binding]; other site
65093005197	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
65093005198	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65093005199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093005200	NAD(P) binding site [chemical binding]; other site
65093005201	active site
65093005202	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
65093005203	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
65093005204	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
65093005205	LDH/MDH dimer interface [polypeptide binding]; other site
65093005206	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
65093005207	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
65093005208	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093005209	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65093005210	active site
65093005211	catalytic tetrad [active]
65093005212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005213	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
65093005214	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093005215	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005217	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
65093005218	putative ADP-binding pocket [chemical binding]; other site
65093005219	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
65093005220	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65093005221	putative CoA binding site [chemical binding]; other site
65093005222	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093005223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005224	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005225	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093005226	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093005227	Methyltransferase domain; Region: Methyltransf_11; pfam08241
65093005228	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093005229	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093005230	active site
65093005231	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005232	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
65093005233	putative ADP-binding pocket [chemical binding]; other site
65093005234	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
65093005235	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
65093005236	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
65093005237	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
65093005238	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093005239	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093005240	active site
65093005241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093005242	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
65093005243	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
65093005244	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
65093005245	Acyltransferase family; Region: Acyl_transf_3; pfam01757
65093005246	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093005247	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093005248	active site
65093005249	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
65093005250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093005251	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093005252	Walker A/P-loop; other site
65093005253	ATP binding site [chemical binding]; other site
65093005254	Q-loop/lid; other site
65093005255	ABC transporter signature motif; other site
65093005256	Walker B; other site
65093005257	D-loop; other site
65093005258	H-loop/switch region; other site
65093005259	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
65093005260	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
65093005261	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093005262	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
65093005263	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
65093005264	Predicted dehydrogenase [General function prediction only]; Region: COG0579
65093005265	hydroxyglutarate oxidase; Provisional; Region: PRK11728
65093005266	GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103
65093005267	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093005268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005269	S-adenosylmethionine binding site [chemical binding]; other site
65093005270	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
65093005271	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093005272	Methyltransferase domain; Region: Methyltransf_12; pfam08242
65093005273	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
65093005274	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
65093005275	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093005276	Methyltransferase domain; Region: Methyltransf_12; pfam08242
65093005277	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
65093005278	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65093005279	extended (e) SDRs; Region: SDR_e; cd08946
65093005280	NAD(P) binding site [chemical binding]; other site
65093005281	active site
65093005282	substrate binding site [chemical binding]; other site
65093005283	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
65093005284	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
65093005285	substrate binding site; other site
65093005286	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
65093005287	Chain length determinant protein; Region: Wzz; pfam02706
65093005288	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
65093005289	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
65093005290	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
65093005291	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
65093005292	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65093005293	folate/biopterin transporter; Region: fbt; TIGR00788
65093005294	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093005295	hydrolase, alpha/beta fold family protein; Region: PLN02824
65093005296	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65093005297	catalytic site [active]
65093005298	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
65093005299	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
65093005300	GTP binding site; other site
65093005301	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005302	putative active site [active]
65093005303	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65093005304	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65093005305	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65093005306	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
65093005307	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
65093005308	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
65093005309	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
65093005310	glycogen branching enzyme; Provisional; Region: PRK05402
65093005311	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
65093005312	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
65093005313	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
65093005314	active site
65093005315	catalytic site [active]
65093005316	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65093005317	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
65093005318	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65093005319	Walker A/P-loop; other site
65093005320	ATP binding site [chemical binding]; other site
65093005321	Q-loop/lid; other site
65093005322	ABC transporter signature motif; other site
65093005323	Walker B; other site
65093005324	D-loop; other site
65093005325	H-loop/switch region; other site
65093005326	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
65093005327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093005328	dimer interface [polypeptide binding]; other site
65093005329	conserved gate region; other site
65093005330	putative PBP binding loops; other site
65093005331	ABC-ATPase subunit interface; other site
65093005332	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
65093005333	plastocyanin; Provisional; Region: PRK02710
65093005334	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
65093005335	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
65093005336	plastocyanin; Provisional; Region: PRK02710
65093005337	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
65093005338	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
65093005339	putative active site [active]
65093005340	Zn binding site [ion binding]; other site
65093005341	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
65093005342	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65093005343	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
65093005344	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65093005345	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65093005346	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
65093005347	dimer interface [polypeptide binding]; other site
65093005348	putative metal binding site [ion binding]; other site
65093005349	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
65093005350	Recombinase; Region: Recombinase; pfam07508
65093005351	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
65093005352	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
65093005353	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
65093005354	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
65093005355	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65093005356	active site
65093005357	dimer interface [polypeptide binding]; other site
65093005358	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
65093005359	CoA binding domain; Region: CoA_binding_2; pfam13380
65093005360	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
65093005361	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
65093005362	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65093005363	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093005364	Coenzyme A binding pocket [chemical binding]; other site
65093005365	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
65093005366	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
65093005367	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
65093005368	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
65093005369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093005370	NAD(P) binding site [chemical binding]; other site
65093005371	active site
65093005372	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
65093005373	protein-splicing catalytic site; other site
65093005374	thioester formation/cholesterol transfer; other site
65093005375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093005376	active site
65093005377	TrkA-N domain; Region: TrkA_N; pfam02254
65093005378	TrkA-N domain; Region: TrkA_N; pfam02254
65093005379	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
65093005380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005381	S-adenosylmethionine binding site [chemical binding]; other site
65093005382	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
65093005383	prolyl-tRNA synthetase; Provisional; Region: PRK09194
65093005384	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
65093005385	dimer interface [polypeptide binding]; other site
65093005386	motif 1; other site
65093005387	active site
65093005388	motif 2; other site
65093005389	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
65093005390	putative deacylase active site [active]
65093005391	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
65093005392	active site
65093005393	motif 3; other site
65093005394	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
65093005395	anticodon binding site; other site
65093005396	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65093005397	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65093005398	Peptidase family M23; Region: Peptidase_M23; pfam01551
65093005399	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65093005400	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
65093005401	[2Fe-2S] cluster binding site [ion binding]; other site
65093005402	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
65093005403	alpha subunit interface [polypeptide binding]; other site
65093005404	active site
65093005405	substrate binding site [chemical binding]; other site
65093005406	Fe binding site [ion binding]; other site
65093005407	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
65093005408	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65093005409	Walker A/P-loop; other site
65093005410	ATP binding site [chemical binding]; other site
65093005411	Q-loop/lid; other site
65093005412	ABC transporter signature motif; other site
65093005413	Walker B; other site
65093005414	D-loop; other site
65093005415	H-loop/switch region; other site
65093005416	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65093005417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093005418	dimer interface [polypeptide binding]; other site
65093005419	conserved gate region; other site
65093005420	putative PBP binding loops; other site
65093005421	ABC-ATPase subunit interface; other site
65093005422	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
65093005423	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
65093005424	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
65093005425	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
65093005426	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
65093005427	agmatinase; Region: agmatinase; TIGR01230
65093005428	Agmatinase-like family; Region: Agmatinase-like; cd09990
65093005429	active site
65093005430	oligomer interface [polypeptide binding]; other site
65093005431	Mn binding site [ion binding]; other site
65093005432	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
65093005433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093005434	Walker A motif; other site
65093005435	ATP binding site [chemical binding]; other site
65093005436	Walker B motif; other site
65093005437	arginine finger; other site
65093005438	Peptidase family M41; Region: Peptidase_M41; pfam01434
65093005439	Protein of unknown function (DUF98); Region: DUF98; pfam01947
65093005440	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
65093005441	active site
65093005442	putative homodimer interface [polypeptide binding]; other site
65093005443	SAM binding site [chemical binding]; other site
65093005444	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
65093005445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005446	S-adenosylmethionine binding site [chemical binding]; other site
65093005447	precorrin-8X methylmutase; Provisional; Region: PRK05954
65093005448	Precorrin-8X methylmutase; Region: CbiC; pfam02570
65093005449	DNA polymerase III subunit delta; Validated; Region: PRK07452
65093005450	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
65093005451	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65093005452	L-asparaginase II; Region: Asparaginase_II; pfam06089
65093005453	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
65093005454	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
65093005455	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65093005456	Zn2+ binding site [ion binding]; other site
65093005457	Mg2+ binding site [ion binding]; other site
65093005458	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
65093005459	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
65093005460	dimer interface [polypeptide binding]; other site
65093005461	motif 1; other site
65093005462	active site
65093005463	motif 2; other site
65093005464	motif 3; other site
65093005465	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
65093005466	anticodon binding site; other site
65093005467	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
65093005468	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
65093005469	dimer interface [polypeptide binding]; other site
65093005470	substrate binding site [chemical binding]; other site
65093005471	ATP binding site [chemical binding]; other site
65093005472	cell division protein FtsZ; Validated; Region: PRK09330
65093005473	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
65093005474	nucleotide binding site [chemical binding]; other site
65093005475	SulA interaction site; other site
65093005476	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
65093005477	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
65093005478	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
65093005479	C-terminal peptidase (prc); Region: prc; TIGR00225
65093005480	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65093005481	protein binding site [polypeptide binding]; other site
65093005482	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65093005483	Catalytic dyad [active]
65093005484	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
65093005485	MgtE intracellular N domain; Region: MgtE_N; smart00924
65093005486	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
65093005487	Divalent cation transporter; Region: MgtE; pfam01769
65093005488	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
65093005489	active site
65093005490	thiamine monophosphate kinase; Provisional; Region: PRK05731
65093005491	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
65093005492	ATP binding site [chemical binding]; other site
65093005493	dimerization interface [polypeptide binding]; other site
65093005494	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093005495	HSP70 interaction site [polypeptide binding]; other site
65093005496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093005497	TPR repeat; Region: TPR_11; pfam13414
65093005498	binding surface
65093005499	TPR motif; other site
65093005500	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65093005501	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
65093005502	active site
65093005503	dimerization interface [polypeptide binding]; other site
65093005504	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
65093005505	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65093005506	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
65093005507	alpha subunit interaction interface [polypeptide binding]; other site
65093005508	Walker A motif; other site
65093005509	ATP binding site [chemical binding]; other site
65093005510	Walker B motif; other site
65093005511	inhibitor binding site; inhibition site
65093005512	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65093005513	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
65093005514	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
65093005515	gamma subunit interface [polypeptide binding]; other site
65093005516	epsilon subunit interface [polypeptide binding]; other site
65093005517	LBP interface [polypeptide binding]; other site
65093005518	hypothetical protein; Provisional; Region: PRK02724
65093005519	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
65093005520	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65093005521	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
65093005522	cyclase homology domain; Region: CHD; cd07302
65093005523	nucleotidyl binding site; other site
65093005524	metal binding site [ion binding]; metal-binding site
65093005525	dimer interface [polypeptide binding]; other site
65093005526	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
65093005527	cyclase homology domain; Region: CHD; cd07302
65093005528	nucleotidyl binding site; other site
65093005529	metal binding site [ion binding]; metal-binding site
65093005530	dimer interface [polypeptide binding]; other site
65093005531	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65093005532	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
65093005533	Cache domain; Region: Cache_1; pfam02743
65093005534	HAMP domain; Region: HAMP; pfam00672
65093005535	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
65093005536	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
65093005537	HIGH motif; other site
65093005538	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65093005539	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
65093005540	active site
65093005541	KMSKS motif; other site
65093005542	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
65093005543	tRNA binding surface [nucleotide binding]; other site
65093005544	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
65093005545	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
65093005546	putative metal binding site [ion binding]; other site
65093005547	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
65093005548	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
65093005549	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
65093005550	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
65093005551	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
65093005552	nickel binding site [ion binding]; other site
65093005553	PBP superfamily domain; Region: PBP_like_2; cl17296
65093005554	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65093005555	metal ion-dependent adhesion site (MIDAS); other site
65093005556	PhoD-like phosphatase; Region: PhoD; pfam09423
65093005557	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
65093005558	putative active site [active]
65093005559	putative metal binding site [ion binding]; other site
65093005560	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
65093005561	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093005562	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65093005563	active site
65093005564	metal binding site [ion binding]; metal-binding site
65093005565	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65093005566	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
65093005567	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
65093005568	FMN binding site [chemical binding]; other site
65093005569	active site
65093005570	catalytic residues [active]
65093005571	substrate binding site [chemical binding]; other site
65093005572	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
65093005573	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
65093005574	Competence protein; Region: Competence; pfam03772
65093005575	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093005576	carotene isomerase; Region: carot_isom; TIGR02730
65093005577	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
65093005578	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
65093005579	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
65093005580	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
65093005581	Late competence development protein ComFB; Region: ComFB; pfam10719
65093005582	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
65093005583	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
65093005584	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
65093005585	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
65093005586	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093005587	DRTGG domain; Region: DRTGG; pfam07085
65093005588	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
65093005589	substrate binding site [chemical binding]; other site
65093005590	active site
65093005591	HEAT repeats; Region: HEAT_2; pfam13646
65093005592	HEAT repeats; Region: HEAT_2; pfam13646
65093005593	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
65093005594	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65093005595	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
65093005596	Uncharacterized conserved protein [Function unknown]; Region: COG0062
65093005597	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
65093005598	putative substrate binding site [chemical binding]; other site
65093005599	putative ATP binding site [chemical binding]; other site
65093005600	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
65093005601	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65093005602	oligomer interface [polypeptide binding]; other site
65093005603	active site residues [active]
65093005604	Clp protease; Region: CLP_protease; pfam00574
65093005605	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65093005606	oligomer interface [polypeptide binding]; other site
65093005607	active site residues [active]
65093005608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093005609	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093005610	Probable transposase; Region: OrfB_IS605; pfam01385
65093005611	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093005612	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65093005613	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
65093005614	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
65093005615	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
65093005616	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
65093005617	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65093005618	allophycocyanin beta subunit; Region: apcB; CHL00088
65093005619	Phycobilisome protein; Region: Phycobilisome; cl08227
65093005620	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
65093005621	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
65093005622	Walker A/P-loop; other site
65093005623	ATP binding site [chemical binding]; other site
65093005624	Q-loop/lid; other site
65093005625	ABC transporter signature motif; other site
65093005626	Walker B; other site
65093005627	D-loop; other site
65093005628	H-loop/switch region; other site
65093005629	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
65093005630	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65093005631	ABC-ATPase subunit  interface; other site
65093005632	dimer interface [polypeptide binding]; other site
65093005633	putative PBP binding regions; other site
65093005634	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
65093005635	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65093005636	ABC-ATPase subunit  interface; other site
65093005637	dimer interface [polypeptide binding]; other site
65093005638	putative PBP binding regions; other site
65093005639	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093005640	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093005641	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093005642	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093005643	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093005644	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093005645	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65093005646	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093005647	hybrid cluster protein; Provisional; Region: PRK05290
65093005648	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093005649	ACS interaction site; other site
65093005650	CODH interaction site; other site
65093005651	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
65093005652	hybrid metal cluster; other site
65093005653	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
65093005654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005655	S-adenosylmethionine binding site [chemical binding]; other site
65093005656	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093005657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093005658	ligand binding site [chemical binding]; other site
65093005659	flexible hinge region; other site
65093005660	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
65093005661	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
65093005662	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
65093005663	metal ion-dependent adhesion site (MIDAS); other site
65093005664	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005665	putative active site [active]
65093005666	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
65093005667	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
65093005668	G1 box; other site
65093005669	GTP/Mg2+ binding site [chemical binding]; other site
65093005670	Switch I region; other site
65093005671	G2 box; other site
65093005672	G3 box; other site
65093005673	Switch II region; other site
65093005674	G4 box; other site
65093005675	G5 box; other site
65093005676	Nucleoside recognition; Region: Gate; pfam07670
65093005677	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
65093005678	FeoA domain; Region: FeoA; pfam04023
65093005679	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
65093005680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093005681	dimerization interface [polypeptide binding]; other site
65093005682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093005683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093005684	dimer interface [polypeptide binding]; other site
65093005685	putative CheW interface [polypeptide binding]; other site
65093005686	Response regulator receiver domain; Region: Response_reg; pfam00072
65093005687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093005688	active site
65093005689	phosphorylation site [posttranslational modification]
65093005690	intermolecular recognition site; other site
65093005691	dimerization interface [polypeptide binding]; other site
65093005692	magnesium chelatase subunit H; Provisional; Region: PRK12493
65093005693	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093005694	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093005695	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
65093005696	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65093005697	inhibitor-cofactor binding pocket; inhibition site
65093005698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093005699	catalytic residue [active]
65093005700	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
65093005701	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093005702	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
65093005703	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
65093005704	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
65093005705	transmembrane helices; other site
65093005706	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
65093005707	TrkA-C domain; Region: TrkA_C; pfam02080
65093005708	TrkA-C domain; Region: TrkA_C; pfam02080
65093005709	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
65093005710	Mg chelatase-related protein; Region: TIGR00368
65093005711	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
65093005712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093005713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65093005714	Walker A motif; other site
65093005715	ATP binding site [chemical binding]; other site
65093005716	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
65093005717	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
65093005718	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
65093005719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093005720	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
65093005721	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
65093005722	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
65093005723	ATP adenylyltransferase; Region: ATP_transf; pfam09830
65093005724	short chain dehydrogenase; Provisional; Region: PRK07454
65093005725	classical (c) SDRs; Region: SDR_c; cd05233
65093005726	NAD(P) binding site [chemical binding]; other site
65093005727	active site
65093005728	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
65093005729	homodecamer interface [polypeptide binding]; other site
65093005730	GTP cyclohydrolase I; Provisional; Region: PLN03044
65093005731	active site
65093005732	putative catalytic site residues [active]
65093005733	zinc binding site [ion binding]; other site
65093005734	GTP-CH-I/GFRP interaction surface; other site
65093005735	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
65093005736	feedback inhibition sensing region; other site
65093005737	homohexameric interface [polypeptide binding]; other site
65093005738	nucleotide binding site [chemical binding]; other site
65093005739	N-acetyl-L-glutamate binding site [chemical binding]; other site
65093005740	Predicted transcriptional regulator [Transcription]; Region: COG1959
65093005741	Transcriptional regulator; Region: Rrf2; pfam02082
65093005742	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
65093005743	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
65093005744	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
65093005745	ATP-grasp domain; Region: ATP-grasp; pfam02222
65093005746	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093005747	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093005748	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093005749	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093005750	dimerization interface [polypeptide binding]; other site
65093005751	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65093005752	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093005753	putative active site [active]
65093005754	heme pocket [chemical binding]; other site
65093005755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093005756	dimer interface [polypeptide binding]; other site
65093005757	phosphorylation site [posttranslational modification]
65093005758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093005759	ATP binding site [chemical binding]; other site
65093005760	Mg2+ binding site [ion binding]; other site
65093005761	G-X-G motif; other site
65093005762	adenylosuccinate lyase; Provisional; Region: PRK07380
65093005763	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
65093005764	tetramer interface [polypeptide binding]; other site
65093005765	active site
65093005766	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
65093005767	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
65093005768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093005769	S-adenosylmethionine binding site [chemical binding]; other site
65093005770	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
65093005771	GXWXG protein; Region: GXWXG; pfam14231
65093005772	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
65093005773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093005774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093005775	ligand binding site [chemical binding]; other site
65093005776	flexible hinge region; other site
65093005777	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
65093005778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093005779	Walker A motif; other site
65093005780	ATP binding site [chemical binding]; other site
65093005781	Walker B motif; other site
65093005782	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
65093005783	4Fe-4S binding domain; Region: Fer4_5; pfam12801
65093005784	4Fe-4S binding domain; Region: Fer4_5; pfam12801
65093005785	photosystem II 47 kDa protein; Region: psbB; CHL00062
65093005786	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
65093005787	30S ribosomal protein S1; Reviewed; Region: PRK07400
65093005788	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
65093005789	RNA binding site [nucleotide binding]; other site
65093005790	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
65093005791	RNA binding site [nucleotide binding]; other site
65093005792	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
65093005793	RNA binding site [nucleotide binding]; other site
65093005794	Transcriptional regulators [Transcription]; Region: FadR; COG2186
65093005795	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
65093005796	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093005797	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093005798	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093005799	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093005800	Clostripain family; Region: Peptidase_C11; pfam03415
65093005801	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
65093005802	Ca2+ binding site [ion binding]; other site
65093005803	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65093005804	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093005805	motif II; other site
65093005806	S-adenosylmethionine synthetase; Validated; Region: PRK05250
65093005807	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
65093005808	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
65093005809	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
65093005810	DNA primase; Validated; Region: dnaG; PRK05667
65093005811	CHC2 zinc finger; Region: zf-CHC2; pfam01807
65093005812	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
65093005813	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
65093005814	active site
65093005815	metal binding site [ion binding]; metal-binding site
65093005816	interdomain interaction site; other site
65093005817	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
65093005818	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65093005819	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
65093005820	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
65093005821	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
65093005822	Caspase domain; Region: Peptidase_C14; pfam00656
65093005823	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093005824	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65093005825	Walker A/P-loop; other site
65093005826	ATP binding site [chemical binding]; other site
65093005827	Q-loop/lid; other site
65093005828	ABC transporter signature motif; other site
65093005829	Walker B; other site
65093005830	D-loop; other site
65093005831	H-loop/switch region; other site
65093005832	hypothetical protein; Provisional; Region: PRK13683
65093005833	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
65093005834	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093005835	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
65093005836	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
65093005837	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
65093005838	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093005839	RNA binding surface [nucleotide binding]; other site
65093005840	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
65093005841	active site
65093005842	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
65093005843	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
65093005844	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
65093005845	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
65093005846	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
65093005847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093005848	dimer interface [polypeptide binding]; other site
65093005849	conserved gate region; other site
65093005850	ABC-ATPase subunit interface; other site
65093005851	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093005852	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093005853	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093005854	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093005855	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65093005856	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093005857	Ligand Binding Site [chemical binding]; other site
65093005858	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
65093005859	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
65093005860	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
65093005861	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093005862	cofactor binding site; other site
65093005863	DNA binding site [nucleotide binding]
65093005864	substrate interaction site [chemical binding]; other site
65093005865	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093005866	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
65093005867	Dynamin family; Region: Dynamin_N; pfam00350
65093005868	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093005869	G1 box; other site
65093005870	GTP/Mg2+ binding site [chemical binding]; other site
65093005871	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005872	putative active site [active]
65093005873	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
65093005874	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
65093005875	substrate binding site; other site
65093005876	dimer interface; other site
65093005877	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
65093005878	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
65093005879	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
65093005880	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
65093005881	oxyanion hole [active]
65093005882	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
65093005883	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
65093005884	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
65093005885	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
65093005886	metal binding site [ion binding]; metal-binding site
65093005887	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093005888	active site
65093005889	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
65093005890	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
65093005891	trimer interface [polypeptide binding]; other site
65093005892	active site
65093005893	substrate binding site [chemical binding]; other site
65093005894	CoA binding site [chemical binding]; other site
65093005895	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
65093005896	AIR carboxylase; Region: AIRC; smart01001
65093005897	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
65093005898	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
65093005899	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
65093005900	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093005901	active site
65093005902	metal binding site [ion binding]; metal-binding site
65093005903	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
65093005904	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
65093005905	catalytic residues [active]
65093005906	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005907	putative active site [active]
65093005908	Protein of unknown function (DUF554); Region: DUF554; pfam04474
65093005909	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
65093005910	alanine racemase; Reviewed; Region: alr; PRK00053
65093005911	active site
65093005912	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65093005913	dimer interface [polypeptide binding]; other site
65093005914	substrate binding site [chemical binding]; other site
65093005915	catalytic residues [active]
65093005916	RloB-like protein; Region: RloB; pfam13707
65093005917	Predicted ATPases [General function prediction only]; Region: COG1106
65093005918	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
65093005919	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
65093005920	nucleotide binding site [chemical binding]; other site
65093005921	putative NEF/HSP70 interaction site [polypeptide binding]; other site
65093005922	SBD interface [polypeptide binding]; other site
65093005923	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
65093005924	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
65093005925	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
65093005926	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
65093005927	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
65093005928	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
65093005929	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
65093005930	DNA binding site [nucleotide binding]
65093005931	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
65093005932	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
65093005933	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
65093005934	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
65093005935	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
65093005936	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
65093005937	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
65093005938	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
65093005939	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
65093005940	RPB10 interaction site [polypeptide binding]; other site
65093005941	RPB1 interaction site [polypeptide binding]; other site
65093005942	RPB11 interaction site [polypeptide binding]; other site
65093005943	RPB3 interaction site [polypeptide binding]; other site
65093005944	RPB12 interaction site [polypeptide binding]; other site
65093005945	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
65093005946	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
65093005947	active site
65093005948	ribosomal protein S20; Region: rps20; CHL00102
65093005949	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
65093005950	histidinol dehydrogenase; Region: hisD; TIGR00069
65093005951	NAD binding site [chemical binding]; other site
65093005952	dimerization interface [polypeptide binding]; other site
65093005953	product binding site; other site
65093005954	substrate binding site [chemical binding]; other site
65093005955	zinc binding site [ion binding]; other site
65093005956	catalytic residues [active]
65093005957	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
65093005958	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
65093005959	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093005960	FeS/SAM binding site; other site
65093005961	photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047
65093005962	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
65093005963	2TM domain; Region: 2TM; pfam13239
65093005964	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
65093005965	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005966	putative active site [active]
65093005967	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
65093005968	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
65093005969	DXD motif; other site
65093005970	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
65093005971	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
65093005972	short chain dehydrogenase; Provisional; Region: PRK12367
65093005973	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093005974	putative active site [active]
65093005975	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
65093005976	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
65093005977	homodimer interface [polypeptide binding]; other site
65093005978	oligonucleotide binding site [chemical binding]; other site
65093005979	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
65093005980	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
65093005981	ligand binding site; other site
65093005982	oligomer interface; other site
65093005983	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
65093005984	dimer interface [polypeptide binding]; other site
65093005985	N-terminal domain interface [polypeptide binding]; other site
65093005986	sulfate 1 binding site; other site
65093005987	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
65093005988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093005989	binding surface
65093005990	TPR motif; other site
65093005991	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
65093005992	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
65093005993	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
65093005994	putative NAD(P) binding site [chemical binding]; other site
65093005995	homodimer interface [polypeptide binding]; other site
65093005996	homotetramer interface [polypeptide binding]; other site
65093005997	active site
65093005998	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65093005999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093006000	Coenzyme A binding pocket [chemical binding]; other site
65093006001	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
65093006002	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
65093006003	G1 box; other site
65093006004	putative GEF interaction site [polypeptide binding]; other site
65093006005	GTP/Mg2+ binding site [chemical binding]; other site
65093006006	Switch I region; other site
65093006007	G2 box; other site
65093006008	G3 box; other site
65093006009	Switch II region; other site
65093006010	G4 box; other site
65093006011	G5 box; other site
65093006012	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
65093006013	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
65093006014	isocitrate dehydrogenase; Validated; Region: PRK07362
65093006015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093006016	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093006017	putative substrate translocation pore; other site
65093006018	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
65093006019	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
65093006020	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65093006021	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
65093006022	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
65093006023	thiS-thiF/thiG interaction site; other site
65093006024	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
65093006025	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
65093006026	thiamine phosphate binding site [chemical binding]; other site
65093006027	active site
65093006028	pyrophosphate binding site [ion binding]; other site
65093006029	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006030	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093006031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006032	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006033	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
65093006034	nickel binding site [ion binding]; other site
65093006035	Uncharacterized conserved protein [Function unknown]; Region: COG0393
65093006036	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
65093006037	arsenical-resistance protein; Region: acr3; TIGR00832
65093006038	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65093006039	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
65093006040	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093006041	catalytic residue [active]
65093006042	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
65093006043	FeS assembly protein SufD; Region: sufD; TIGR01981
65093006044	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
65093006045	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
65093006046	Walker A/P-loop; other site
65093006047	ATP binding site [chemical binding]; other site
65093006048	Q-loop/lid; other site
65093006049	ABC transporter signature motif; other site
65093006050	Walker B; other site
65093006051	D-loop; other site
65093006052	H-loop/switch region; other site
65093006053	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
65093006054	putative ABC transporter; Region: ycf24; CHL00085
65093006055	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65093006056	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
65093006057	putative DNA binding site [nucleotide binding]; other site
65093006058	putative Zn2+ binding site [ion binding]; other site
65093006059	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65093006060	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65093006061	putative acyl-acceptor binding pocket; other site
65093006062	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
65093006063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093006064	Walker A/P-loop; other site
65093006065	ATP binding site [chemical binding]; other site
65093006066	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
65093006067	AMP binding site [chemical binding]; other site
65093006068	metal binding site [ion binding]; metal-binding site
65093006069	active site
65093006070	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
65093006071	putative active site [active]
65093006072	transaldolase; Provisional; Region: PRK03903
65093006073	catalytic residue [active]
65093006074	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
65093006075	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
65093006076	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
65093006077	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
65093006078	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
65093006079	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
65093006080	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093006081	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
65093006082	catalytic triad [active]
65093006083	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
65093006084	Cytochrome B6-F complex subunit 5; Region: PetG; cl03637
65093006085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006086	active site
65093006087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093006088	phosphorylation site [posttranslational modification]
65093006089	intermolecular recognition site; other site
65093006090	dimerization interface [polypeptide binding]; other site
65093006091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006092	dimer interface [polypeptide binding]; other site
65093006093	phosphorylation site [posttranslational modification]
65093006094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006095	ATP binding site [chemical binding]; other site
65093006096	Mg2+ binding site [ion binding]; other site
65093006097	G-X-G motif; other site
65093006098	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
65093006099	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
65093006100	NAD(P) binding site [chemical binding]; other site
65093006101	catalytic residues [active]
65093006102	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
65093006103	dihydropteroate synthase; Region: DHPS; TIGR01496
65093006104	substrate binding pocket [chemical binding]; other site
65093006105	dimer interface [polypeptide binding]; other site
65093006106	inhibitor binding site; inhibition site
65093006107	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
65093006108	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
65093006109	active site
65093006110	catalytic residues [active]
65093006111	metal binding site [ion binding]; metal-binding site
65093006112	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
65093006113	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65093006114	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65093006115	P-loop; other site
65093006116	Magnesium ion binding site [ion binding]; other site
65093006117	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65093006118	Magnesium ion binding site [ion binding]; other site
65093006119	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
65093006120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093006121	Walker A motif; other site
65093006122	ATP binding site [chemical binding]; other site
65093006123	Walker B motif; other site
65093006124	arginine finger; other site
65093006125	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
65093006126	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
65093006127	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
65093006128	substrate binding site [chemical binding]; other site
65093006129	glutamase interaction surface [polypeptide binding]; other site
65093006130	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
65093006131	Uncharacterized conserved protein [Function unknown]; Region: COG3472
65093006132	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
65093006133	PLD-like domain; Region: PLDc_2; pfam13091
65093006134	putative active site [active]
65093006135	catalytic site [active]
65093006136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093006137	ATP binding site [chemical binding]; other site
65093006138	putative Mg++ binding site [ion binding]; other site
65093006139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093006140	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
65093006141	nucleotide binding region [chemical binding]; other site
65093006142	ATP-binding site [chemical binding]; other site
65093006143	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65093006144	non-specific DNA binding site [nucleotide binding]; other site
65093006145	salt bridge; other site
65093006146	sequence-specific DNA binding site [nucleotide binding]; other site
65093006147	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093006148	putative active site [active]
65093006149	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093006150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093006151	S-adenosylmethionine binding site [chemical binding]; other site
65093006152	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65093006153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006154	putative active site [active]
65093006155	heme pocket [chemical binding]; other site
65093006156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006157	dimer interface [polypeptide binding]; other site
65093006158	phosphorylation site [posttranslational modification]
65093006159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006160	ATP binding site [chemical binding]; other site
65093006161	Mg2+ binding site [ion binding]; other site
65093006162	G-X-G motif; other site
65093006163	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093006164	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
65093006165	FAD binding domain; Region: FAD_binding_4; pfam01565
65093006166	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
65093006167	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
65093006168	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
65093006169	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
65093006170	putative active site [active]
65093006171	oxyanion strand; other site
65093006172	catalytic triad [active]
65093006173	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
65093006174	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
65093006175	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
65093006176	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65093006177	Protein phosphatase 2C; Region: PP2C; pfam00481
65093006178	active site
65093006179	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65093006180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093006181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093006182	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
65093006183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093006184	motif II; other site
65093006185	High-affinity nickel-transport protein; Region: NicO; cl00964
65093006186	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
65093006187	proline aminopeptidase P II; Provisional; Region: PRK10879
65093006188	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
65093006189	active site
65093006190	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093006191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006192	active site
65093006193	phosphorylation site [posttranslational modification]
65093006194	intermolecular recognition site; other site
65093006195	dimerization interface [polypeptide binding]; other site
65093006196	AIR carboxylase; Region: AIRC; pfam00731
65093006197	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
65093006198	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
65093006199	Walker A/P-loop; other site
65093006200	ATP binding site [chemical binding]; other site
65093006201	Q-loop/lid; other site
65093006202	ABC transporter signature motif; other site
65093006203	Walker B; other site
65093006204	D-loop; other site
65093006205	H-loop/switch region; other site
65093006206	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093006207	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
65093006208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093006209	dimer interface [polypeptide binding]; other site
65093006210	conserved gate region; other site
65093006211	putative PBP binding loops; other site
65093006212	ABC-ATPase subunit interface; other site
65093006213	PAS domain S-box; Region: sensory_box; TIGR00229
65093006214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006215	putative active site [active]
65093006216	heme pocket [chemical binding]; other site
65093006217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006218	PAS fold; Region: PAS_3; pfam08447
65093006219	putative active site [active]
65093006220	heme pocket [chemical binding]; other site
65093006221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006222	PAS fold; Region: PAS_3; pfam08447
65093006223	putative active site [active]
65093006224	heme pocket [chemical binding]; other site
65093006225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093006226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006227	dimer interface [polypeptide binding]; other site
65093006228	phosphorylation site [posttranslational modification]
65093006229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006230	ATP binding site [chemical binding]; other site
65093006231	Mg2+ binding site [ion binding]; other site
65093006232	G-X-G motif; other site
65093006233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006234	active site
65093006235	phosphorylation site [posttranslational modification]
65093006236	dimerization interface [polypeptide binding]; other site
65093006237	Response regulator receiver domain; Region: Response_reg; pfam00072
65093006238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006239	active site
65093006240	phosphorylation site [posttranslational modification]
65093006241	intermolecular recognition site; other site
65093006242	dimerization interface [polypeptide binding]; other site
65093006243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093006244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006245	dimer interface [polypeptide binding]; other site
65093006246	phosphorylation site [posttranslational modification]
65093006247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006248	ATP binding site [chemical binding]; other site
65093006249	Mg2+ binding site [ion binding]; other site
65093006250	G-X-G motif; other site
65093006251	DNA photolyase; Region: DNA_photolyase; pfam00875
65093006252	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
65093006253	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
65093006254	putative lipid kinase; Reviewed; Region: PRK13057
65093006255	Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185
65093006256	Low molecular weight phosphatase family; Region: LMWPc; cd00115
65093006257	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
65093006258	active site
65093006259	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
65093006260	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
65093006261	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
65093006262	NAD(P) binding site [chemical binding]; other site
65093006263	methionine sulfoxide reductase B; Provisional; Region: PRK00222
65093006264	SelR domain; Region: SelR; pfam01641
65093006265	photosystem II protein K; Region: psbK; CHL00047
65093006266	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
65093006267	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
65093006268	cobalamin synthase; Reviewed; Region: cobS; PRK00235
65093006269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093006270	TPR repeat; Region: TPR_11; pfam13414
65093006271	binding surface
65093006272	TPR motif; other site
65093006273	thymidylate kinase; Validated; Region: tmk; PRK00698
65093006274	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
65093006275	TMP-binding site; other site
65093006276	ATP-binding site [chemical binding]; other site
65093006277	phosphoglucomutase; Region: PLN02307
65093006278	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
65093006279	substrate binding site [chemical binding]; other site
65093006280	dimer interface [polypeptide binding]; other site
65093006281	active site
65093006282	metal binding site [ion binding]; metal-binding site
65093006283	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65093006284	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65093006285	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
65093006286	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
65093006287	KGK domain; Region: KGK; pfam08872
65093006288	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
65093006289	Ycf46; Provisional; Region: ycf46; CHL00195
65093006290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093006291	Walker A motif; other site
65093006292	ATP binding site [chemical binding]; other site
65093006293	Walker B motif; other site
65093006294	arginine finger; other site
65093006295	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
65093006296	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
65093006297	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65093006298	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093006299	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093006300	putative active site [active]
65093006301	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
65093006302	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65093006303	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65093006304	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
65093006305	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
65093006306	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
65093006307	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65093006308	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
65093006309	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
65093006310	nucleotide binding site [chemical binding]; other site
65093006311	putative NEF/HSP70 interaction site [polypeptide binding]; other site
65093006312	SBD interface [polypeptide binding]; other site
65093006313	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
65093006314	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006315	GAF domain; Region: GAF; pfam01590
65093006316	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093006317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006318	dimer interface [polypeptide binding]; other site
65093006319	phosphorylation site [posttranslational modification]
65093006320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006321	ATP binding site [chemical binding]; other site
65093006322	Mg2+ binding site [ion binding]; other site
65093006323	G-X-G motif; other site
65093006324	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093006325	phosphopeptide binding site; other site
65093006326	Transglycosylase; Region: Transgly; pfam00912
65093006327	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
65093006328	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
65093006329	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
65093006330	lipoprotein signal peptidase; Provisional; Region: PRK14787
65093006331	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
65093006332	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
65093006333	active site
65093006334	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
65093006335	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
65093006336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093006337	Walker A/P-loop; other site
65093006338	ATP binding site [chemical binding]; other site
65093006339	Q-loop/lid; other site
65093006340	ABC transporter signature motif; other site
65093006341	Walker B; other site
65093006342	D-loop; other site
65093006343	sucrose synthase; Region: sucr_synth; TIGR02470
65093006344	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65093006345	putative ADP-binding pocket [chemical binding]; other site
65093006346	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
65093006347	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
65093006348	Ligand binding site; other site
65093006349	Putative Catalytic site; other site
65093006350	DXD motif; other site
65093006351	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
65093006352	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
65093006353	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
65093006354	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
65093006355	active site residue [active]
65093006356	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
65093006357	active site residue [active]
65093006358	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
65093006359	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
65093006360	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
65093006361	Protein of unknown function (DUF760); Region: DUF760; pfam05542
65093006362	GTPase CgtA; Reviewed; Region: obgE; PRK12299
65093006363	GTP1/OBG; Region: GTP1_OBG; pfam01018
65093006364	Obg GTPase; Region: Obg; cd01898
65093006365	G1 box; other site
65093006366	GTP/Mg2+ binding site [chemical binding]; other site
65093006367	Switch I region; other site
65093006368	G2 box; other site
65093006369	G3 box; other site
65093006370	Switch II region; other site
65093006371	G4 box; other site
65093006372	G5 box; other site
65093006373	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
65093006374	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65093006375	minor groove reading motif; other site
65093006376	helix-hairpin-helix signature motif; other site
65093006377	substrate binding pocket [chemical binding]; other site
65093006378	active site
65093006379	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
65093006380	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
65093006381	active site
65093006382	8-oxo-dGMP binding site [chemical binding]; other site
65093006383	nudix motif; other site
65093006384	metal binding site [ion binding]; metal-binding site
65093006385	Protein of unknown function (DUF760); Region: DUF760; pfam05542
65093006386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006387	PAS domain; Region: PAS_9; pfam13426
65093006388	putative active site [active]
65093006389	heme pocket [chemical binding]; other site
65093006390	PAS domain S-box; Region: sensory_box; TIGR00229
65093006391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006392	putative active site [active]
65093006393	heme pocket [chemical binding]; other site
65093006394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093006395	metal binding site [ion binding]; metal-binding site
65093006396	active site
65093006397	I-site; other site
65093006398	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093006399	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
65093006400	active site
65093006401	dimer interface [polypeptide binding]; other site
65093006402	PsbP; Region: PsbP; pfam01789
65093006403	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093006404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093006405	S-adenosylmethionine binding site [chemical binding]; other site
65093006406	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
65093006407	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
65093006408	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65093006409	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
65093006410	metal-binding site [ion binding]
65093006411	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093006412	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093006413	motif II; other site
65093006414	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006415	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093006416	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006417	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093006418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093006419	TPR repeat; Region: TPR_11; pfam13414
65093006420	TPR motif; other site
65093006421	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
65093006422	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
65093006423	Zn binding site [ion binding]; other site
65093006424	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65093006425	Membrane fusogenic activity; Region: BMFP; cl01115
65093006426	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
65093006427	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
65093006428	putative Iron-sulfur protein interface [polypeptide binding]; other site
65093006429	proximal heme binding site [chemical binding]; other site
65093006430	distal heme binding site [chemical binding]; other site
65093006431	putative dimer interface [polypeptide binding]; other site
65093006432	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
65093006433	L-aspartate oxidase; Provisional; Region: PRK06175
65093006434	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
65093006435	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
65093006436	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093006437	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
65093006438	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
65093006439	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65093006440	Peptidase family M23; Region: Peptidase_M23; pfam01551
65093006441	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65093006442	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65093006443	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093006444	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
65093006445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093006446	NAD(P) binding site [chemical binding]; other site
65093006447	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
65093006448	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
65093006449	active site
65093006450	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
65093006451	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
65093006452	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
65093006453	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
65093006454	Hemerythrin; Region: Hemerythrin; cd12107
65093006455	Fe binding site [ion binding]; other site
65093006456	Hemerythrin; Region: Hemerythrin; cd12107
65093006457	Fe binding site [ion binding]; other site
65093006458	Hemerythrin; Region: Hemerythrin; cd12107
65093006459	Fe binding site [ion binding]; other site
65093006460	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
65093006461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093006462	motif II; other site
65093006463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
65093006464	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093006465	active site
65093006466	phosphorylation site [posttranslational modification]
65093006467	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093006468	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093006469	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
65093006470	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
65093006471	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
65093006472	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093006473	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093006474	HSP70 interaction site [polypeptide binding]; other site
65093006475	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65093006476	substrate binding site [polypeptide binding]; other site
65093006477	dimer interface [polypeptide binding]; other site
65093006478	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65093006479	active site
65093006480	NTP binding site [chemical binding]; other site
65093006481	metal binding triad [ion binding]; metal-binding site
65093006482	antibiotic binding site [chemical binding]; other site
65093006483	Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250
65093006484	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
65093006485	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093006486	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
65093006487	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
65093006488	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
65093006489	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
65093006490	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65093006491	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
65093006492	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
65093006493	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65093006494	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65093006495	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
65093006496	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
65093006497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093006498	Walker A motif; other site
65093006499	ATP binding site [chemical binding]; other site
65093006500	Walker B motif; other site
65093006501	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
65093006502	RxxxH motif; other site
65093006503	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
65093006504	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093006505	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
65093006506	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
65093006507	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
65093006508	putative metal binding site [ion binding]; other site
65093006509	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
65093006510	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
65093006511	putative metal binding site [ion binding]; other site
65093006512	rod shape-determining protein MreC; Provisional; Region: PRK13922
65093006513	rod shape-determining protein MreC; Region: MreC; pfam04085
65093006514	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65093006515	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
65093006516	DNA protecting protein DprA; Region: dprA; TIGR00732
65093006517	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
65093006518	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
65093006519	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
65093006520	Protein of unknown function (DUF938); Region: DUF938; pfam06080
65093006521	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
65093006522	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
65093006523	active site
65093006524	SAM binding site [chemical binding]; other site
65093006525	homodimer interface [polypeptide binding]; other site
65093006526	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093006527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006528	active site
65093006529	phosphorylation site [posttranslational modification]
65093006530	intermolecular recognition site; other site
65093006531	dimerization interface [polypeptide binding]; other site
65093006532	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093006533	DNA binding residues [nucleotide binding]
65093006534	dimerization interface [polypeptide binding]; other site
65093006535	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
65093006536	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
65093006537	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65093006538	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
65093006539	active site
65093006540	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
65093006541	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65093006542	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
65093006543	Protein of unknown function (DUF565); Region: DUF565; pfam04483
65093006544	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65093006545	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
65093006546	FtsX-like permease family; Region: FtsX; pfam02687
65093006547	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65093006548	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65093006549	GTP-binding protein YchF; Reviewed; Region: PRK09601
65093006550	YchF GTPase; Region: YchF; cd01900
65093006551	G1 box; other site
65093006552	GTP/Mg2+ binding site [chemical binding]; other site
65093006553	Switch I region; other site
65093006554	G2 box; other site
65093006555	Switch II region; other site
65093006556	G3 box; other site
65093006557	G4 box; other site
65093006558	G5 box; other site
65093006559	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
65093006560	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093006561	putative active site [active]
65093006562	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
65093006563	light-harvesting-like protein 3; Provisional; Region: PLN00014
65093006564	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65093006565	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65093006566	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65093006567	protein binding site [polypeptide binding]; other site
65093006568	CHASE3 domain; Region: CHASE3; pfam05227
65093006569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006570	dimer interface [polypeptide binding]; other site
65093006571	phosphorylation site [posttranslational modification]
65093006572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006573	ATP binding site [chemical binding]; other site
65093006574	Mg2+ binding site [ion binding]; other site
65093006575	G-X-G motif; other site
65093006576	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093006577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006578	active site
65093006579	phosphorylation site [posttranslational modification]
65093006580	intermolecular recognition site; other site
65093006581	dimerization interface [polypeptide binding]; other site
65093006582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093006583	active site
65093006584	phosphorylation site [posttranslational modification]
65093006585	intermolecular recognition site; other site
65093006586	dimerization interface [polypeptide binding]; other site
65093006587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006588	PAS fold; Region: PAS_3; pfam08447
65093006589	putative active site [active]
65093006590	heme pocket [chemical binding]; other site
65093006591	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006592	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093006593	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006594	GAF domain; Region: GAF_3; pfam13492
65093006595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093006596	dimer interface [polypeptide binding]; other site
65093006597	phosphorylation site [posttranslational modification]
65093006598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093006599	ATP binding site [chemical binding]; other site
65093006600	Mg2+ binding site [ion binding]; other site
65093006601	G-X-G motif; other site
65093006602	signal recognition particle protein; Provisional; Region: PRK10867
65093006603	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
65093006604	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
65093006605	P loop; other site
65093006606	GTP binding site [chemical binding]; other site
65093006607	Signal peptide binding domain; Region: SRP_SPB; pfam02978
65093006608	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
65093006609	nudix motif; other site
65093006610	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093006611	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
65093006612	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
65093006613	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
65093006614	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
65093006615	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
65093006616	putative active site [active]
65093006617	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
65093006618	putative active site [active]
65093006619	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
65093006620	active site
65093006621	SAM binding site [chemical binding]; other site
65093006622	homodimer interface [polypeptide binding]; other site
65093006623	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
65093006624	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
65093006625	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
65093006626	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093006627	G1 box; other site
65093006628	GTP/Mg2+ binding site [chemical binding]; other site
65093006629	G2 box; other site
65093006630	Switch I region; other site
65093006631	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093006632	G3 box; other site
65093006633	Switch II region; other site
65093006634	GTP/Mg2+ binding site [chemical binding]; other site
65093006635	G4 box; other site
65093006636	G5 box; other site
65093006637	KGK domain; Region: KGK; pfam08872
65093006638	KGK domain; Region: KGK; pfam08872
65093006639	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093006640	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093006641	active site
65093006642	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093006643	putative active site [active]
65093006644	GUN4-like; Region: GUN4; pfam05419
65093006645	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
65093006646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093006647	S-adenosylmethionine binding site [chemical binding]; other site
65093006648	Tic22-like family; Region: Tic22; pfam04278
65093006649	Cytochrome P450; Region: p450; cl12078
65093006650	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65093006651	GLTT repeat (6 copies); Region: GLTT; pfam01744
65093006652	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65093006653	Cytochrome P450; Region: p450; pfam00067
65093006654	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
65093006655	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
65093006656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
65093006657	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
65093006658	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
65093006659	dimer interface [polypeptide binding]; other site
65093006660	active site
65093006661	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093006662	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
65093006663	active site
65093006664	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
65093006665	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
65093006666	D1 interface; other site
65093006667	chlorophyll binding site; other site
65093006668	pheophytin binding site; other site
65093006669	beta carotene binding site; other site
65093006670	cytochrome b559 beta interface; other site
65093006671	quinone binding site; other site
65093006672	cytochrome b559 alpha interface; other site
65093006673	protein J interface; other site
65093006674	protein H interface; other site
65093006675	protein X interface; other site
65093006676	core light harvesting protein interface; other site
65093006677	protein L interface; other site
65093006678	CP43 interface; other site
65093006679	protein T interface; other site
65093006680	Fe binding site [ion binding]; other site
65093006681	protein M interface; other site
65093006682	Mn-stabilizing polypeptide interface; other site
65093006683	bromide binding site; other site
65093006684	cytochrome c-550 interface; other site
65093006685	Photosystem II protein; Region: PSII; cl08223
65093006686	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
65093006687	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
65093006688	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
65093006689	Ligand binding site; other site
65093006690	metal-binding site
65093006691	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
65093006692	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
65093006693	XdhC Rossmann domain; Region: XdhC_C; pfam13478
65093006694	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
65093006695	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
65093006696	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
65093006697	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
65093006698	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
65093006699	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
65093006700	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
65093006701	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
65093006702	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093006703	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093006704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093006705	Walker A/P-loop; other site
65093006706	ATP binding site [chemical binding]; other site
65093006707	Q-loop/lid; other site
65093006708	ABC transporter signature motif; other site
65093006709	Walker B; other site
65093006710	D-loop; other site
65093006711	H-loop/switch region; other site
65093006712	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
65093006713	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093006714	Protein kinase domain; Region: Pkinase; pfam00069
65093006715	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093006716	active site
65093006717	ATP binding site [chemical binding]; other site
65093006718	substrate binding site [chemical binding]; other site
65093006719	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65093006720	substrate binding site [chemical binding]; other site
65093006721	activation loop (A-loop); other site
65093006722	activation loop (A-loop); other site
65093006723	AAA ATPase domain; Region: AAA_16; pfam13191
65093006724	Predicted ATPase [General function prediction only]; Region: COG3899
65093006725	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006726	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093006727	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
65093006728	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65093006729	putative substrate binding site [chemical binding]; other site
65093006730	putative ATP binding site [chemical binding]; other site
65093006731	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65093006732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093006733	ATP binding site [chemical binding]; other site
65093006734	putative Mg++ binding site [ion binding]; other site
65093006735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093006736	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
65093006737	nucleotide binding region [chemical binding]; other site
65093006738	ATP-binding site [chemical binding]; other site
65093006739	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
65093006740	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65093006741	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
65093006742	translation initiation factor IF-2; Region: IF-2; TIGR00487
65093006743	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
65093006744	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
65093006745	G1 box; other site
65093006746	putative GEF interaction site [polypeptide binding]; other site
65093006747	GTP/Mg2+ binding site [chemical binding]; other site
65093006748	Switch I region; other site
65093006749	G2 box; other site
65093006750	G3 box; other site
65093006751	Switch II region; other site
65093006752	G4 box; other site
65093006753	G5 box; other site
65093006754	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
65093006755	Translation-initiation factor 2; Region: IF-2; pfam11987
65093006756	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
65093006757	Protein of unknown function (DUF448); Region: DUF448; pfam04296
65093006758	putative RNA binding cleft [nucleotide binding]; other site
65093006759	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
65093006760	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
65093006761	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
65093006762	[4Fe-4S] binding site [ion binding]; other site
65093006763	molybdopterin cofactor binding site; other site
65093006764	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
65093006765	molybdopterin cofactor binding site; other site
65093006766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093006767	putative substrate translocation pore; other site
65093006768	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093006769	putative active site [active]
65093006770	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65093006771	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65093006772	active site
65093006773	catalytic tetrad [active]
65093006774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093006775	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093006776	replicative DNA helicase; Region: DnaB; TIGR00665
65093006777	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
65093006778	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
65093006779	Walker A motif; other site
65093006780	ATP binding site [chemical binding]; other site
65093006781	Walker B motif; other site
65093006782	DNA binding loops [nucleotide binding]
65093006783	CheB methylesterase; Region: CheB_methylest; pfam01339
65093006784	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
65093006785	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
65093006786	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
65093006787	PAS domain; Region: PAS_10; pfam13596
65093006788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006789	PAS domain; Region: PAS_9; pfam13426
65093006790	putative active site [active]
65093006791	heme pocket [chemical binding]; other site
65093006792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093006793	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093006794	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093006795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006796	PAS domain; Region: PAS_9; pfam13426
65093006797	putative active site [active]
65093006798	heme pocket [chemical binding]; other site
65093006799	PAS fold; Region: PAS_4; pfam08448
65093006800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093006802	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093006803	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093006804	metal binding site [ion binding]; metal-binding site
65093006805	active site
65093006806	I-site; other site
65093006807	CAAX protease self-immunity; Region: Abi; pfam02517
65093006808	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65093006809	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65093006810	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
65093006811	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
65093006812	DXD motif; other site
65093006813	Cellulose synthase-like protein; Region: PLN02893
65093006814	PilZ domain; Region: PilZ; pfam07238
65093006815	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093006816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093006817	Probable transposase; Region: OrfB_IS605; pfam01385
65093006818	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093006819	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
65093006820	active site pocket [active]
65093006821	putative dimer interface [polypeptide binding]; other site
65093006822	putative cataytic base [active]
65093006823	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
65093006824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65093006825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093006826	catalytic residue [active]
65093006827	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
65093006828	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
65093006829	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006830	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093006831	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093006832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006833	putative active site [active]
65093006834	heme pocket [chemical binding]; other site
65093006835	PAS domain; Region: PAS_8; pfam13188
65093006836	putative active site [active]
65093006837	heme pocket [chemical binding]; other site
65093006838	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
65093006839	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093006840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093006841	metal binding site [ion binding]; metal-binding site
65093006842	active site
65093006843	I-site; other site
65093006844	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093006845	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
65093006846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093006847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093006848	homodimer interface [polypeptide binding]; other site
65093006849	catalytic residue [active]
65093006850	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
65093006851	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
65093006852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093006853	catalytic residue [active]
65093006854	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
65093006855	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
65093006856	catalytic site [active]
65093006857	putative active site [active]
65093006858	putative substrate binding site [chemical binding]; other site
65093006859	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
65093006860	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
65093006861	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
65093006862	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
65093006863	active site
65093006864	SAM binding site [chemical binding]; other site
65093006865	homodimer interface [polypeptide binding]; other site
65093006866	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
65093006867	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65093006868	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
65093006869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093006870	Probable transposase; Region: OrfB_IS605; pfam01385
65093006871	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093006872	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
65093006873	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
65093006874	PAS fold; Region: PAS_4; pfam08448
65093006875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006876	putative active site [active]
65093006877	heme pocket [chemical binding]; other site
65093006878	GAF domain; Region: GAF; pfam01590
65093006879	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093006880	PAS domain S-box; Region: sensory_box; TIGR00229
65093006881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093006882	putative active site [active]
65093006883	heme pocket [chemical binding]; other site
65093006884	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093006885	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093006886	metal binding site [ion binding]; metal-binding site
65093006887	active site
65093006888	I-site; other site
65093006889	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65093006890	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
65093006891	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
65093006892	active site
65093006893	nucleotide binding site [chemical binding]; other site
65093006894	HIGH motif; other site
65093006895	KMSKS motif; other site
65093006896	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65093006897	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
65093006898	Protein of unknown function (DUF790); Region: DUF790; pfam05626
65093006899	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65093006900	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093006901	putative active site [active]
65093006902	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
65093006903	DNA gyrase subunit A; Validated; Region: PRK05560
65093006904	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
65093006905	CAP-like domain; other site
65093006906	active site
65093006907	primary dimer interface [polypeptide binding]; other site
65093006908	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006909	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006910	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006911	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006912	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006913	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65093006914	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
65093006915	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65093006916	metal binding site 2 [ion binding]; metal-binding site
65093006917	putative DNA binding helix; other site
65093006918	metal binding site 1 [ion binding]; metal-binding site
65093006919	dimer interface [polypeptide binding]; other site
65093006920	structural Zn2+ binding site [ion binding]; other site
65093006921	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65093006922	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093006923	ATP binding site [chemical binding]; other site
65093006924	putative Mg++ binding site [ion binding]; other site
65093006925	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093006926	nucleotide binding region [chemical binding]; other site
65093006927	ATP-binding site [chemical binding]; other site
65093006928	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
65093006929	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093006930	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
65093006931	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65093006932	putative switch regulator; other site
65093006933	non-specific DNA interactions [nucleotide binding]; other site
65093006934	DNA binding site [nucleotide binding]
65093006935	sequence specific DNA binding site [nucleotide binding]; other site
65093006936	putative cAMP binding site [chemical binding]; other site
65093006937	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65093006938	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
65093006939	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
65093006940	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093006941	putative active site [active]
65093006942	Uncharacterized conserved protein [Function unknown]; Region: COG1615
65093006943	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
65093006944	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
65093006945	TIGR02588 family protein; Region: TIGR02588
65093006946	Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935
65093006947	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
65093006948	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
65093006949	putative homodimer interface [polypeptide binding]; other site
65093006950	putative active site pocket [active]
65093006951	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
65093006952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093006953	binding surface
65093006954	TPR motif; other site
65093006955	TPR repeat; Region: TPR_11; pfam13414
65093006956	TPR repeat; Region: TPR_11; pfam13414
65093006957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093006958	binding surface
65093006959	TPR motif; other site
65093006960	TPR repeat; Region: TPR_11; pfam13414
65093006961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093006962	binding surface
65093006963	TPR motif; other site
65093006964	TPR repeat; Region: TPR_11; pfam13414
65093006965	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
65093006966	putative hexamer interface [polypeptide binding]; other site
65093006967	putative hexagonal pore; other site
65093006968	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
65093006969	Hexamer interface [polypeptide binding]; other site
65093006970	Hexagonal pore residue; other site
65093006971	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65093006972	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65093006973	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65093006974	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65093006975	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65093006976	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65093006977	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65093006978	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65093006979	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
65093006980	HEAT repeats; Region: HEAT_2; pfam13646
65093006981	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65093006982	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
65093006983	HEAT repeats; Region: HEAT_2; pfam13646
65093006984	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65093006985	NurA domain; Region: NurA; pfam09376
65093006986	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
65093006987	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
65093006988	ribosomal protein L32; Validated; Region: rpl32; CHL00152
65093006989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093006990	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093006991	Probable transposase; Region: OrfB_IS605; pfam01385
65093006992	yiaA/B two helix domain; Region: YiaAB; cl01759
65093006993	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
65093006994	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
65093006995	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
65093006996	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
65093006997	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
65093006998	HIGH motif; other site
65093006999	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65093007000	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
65093007001	active site
65093007002	KMSKS motif; other site
65093007003	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
65093007004	tRNA binding surface [nucleotide binding]; other site
65093007005	anticodon binding site; other site
65093007006	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
65093007007	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
65093007008	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
65093007009	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
65093007010	TIGR01777 family protein; Region: yfcH
65093007011	putative NAD(P) binding site [chemical binding]; other site
65093007012	putative active site [active]
65093007013	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093007014	HSP70 interaction site [polypeptide binding]; other site
65093007015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093007016	binding surface
65093007017	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093007018	TPR motif; other site
65093007019	Uncharacterized conserved protein [Function unknown]; Region: COG1565
65093007020	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65093007021	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65093007022	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65093007023	catalytic residue [active]
65093007024	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
65093007025	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
65093007026	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
65093007027	glutamine synthetase, type I; Region: GlnA; TIGR00653
65093007028	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
65093007029	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
65093007030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007031	S-adenosylmethionine binding site [chemical binding]; other site
65093007032	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
65093007033	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65093007034	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
65093007035	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
65093007036	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
65093007037	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
65093007038	active site
65093007039	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
65093007040	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
65093007041	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
65093007042	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
65093007043	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65093007044	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
65093007045	Surface antigen; Region: Bac_surface_Ag; pfam01103
65093007046	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
65093007047	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
65093007048	ATP binding site [chemical binding]; other site
65093007049	active site
65093007050	substrate binding site [chemical binding]; other site
65093007051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093007052	Probable transposase; Region: OrfB_IS605; pfam01385
65093007053	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093007054	heat shock protein 90; Provisional; Region: PRK05218
65093007055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007056	ATP binding site [chemical binding]; other site
65093007057	Mg2+ binding site [ion binding]; other site
65093007058	G-X-G motif; other site
65093007059	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65093007060	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65093007061	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
65093007062	putative active site [active]
65093007063	putative NTP binding site [chemical binding]; other site
65093007064	putative nucleic acid binding site [nucleotide binding]; other site
65093007065	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
65093007066	putative active site [active]
65093007067	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
65093007068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093007069	Walker A/P-loop; other site
65093007070	ATP binding site [chemical binding]; other site
65093007071	Q-loop/lid; other site
65093007072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093007073	ABC transporter signature motif; other site
65093007074	Walker B; other site
65093007075	D-loop; other site
65093007076	H-loop/switch region; other site
65093007077	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
65093007078	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
65093007079	tRNA; other site
65093007080	putative tRNA binding site [nucleotide binding]; other site
65093007081	putative NADP binding site [chemical binding]; other site
65093007082	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
65093007083	hypothetical protein; Validated; Region: PRK07413
65093007084	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
65093007085	homodimer interface [polypeptide binding]; other site
65093007086	Walker A motif; other site
65093007087	ATP binding site [chemical binding]; other site
65093007088	hydroxycobalamin binding site [chemical binding]; other site
65093007089	Walker B motif; other site
65093007090	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
65093007091	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
65093007092	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093007093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093007094	homodimer interface [polypeptide binding]; other site
65093007095	catalytic residue [active]
65093007096	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
65093007097	elongation factor G; Reviewed; Region: PRK12740
65093007098	G1 box; other site
65093007099	putative GEF interaction site [polypeptide binding]; other site
65093007100	GTP/Mg2+ binding site [chemical binding]; other site
65093007101	Switch I region; other site
65093007102	G2 box; other site
65093007103	G3 box; other site
65093007104	Switch II region; other site
65093007105	G4 box; other site
65093007106	G5 box; other site
65093007107	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
65093007108	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
65093007109	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
65093007110	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
65093007111	core domain interface [polypeptide binding]; other site
65093007112	delta subunit interface [polypeptide binding]; other site
65093007113	epsilon subunit interface [polypeptide binding]; other site
65093007114	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
65093007115	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65093007116	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
65093007117	beta subunit interaction interface [polypeptide binding]; other site
65093007118	Walker A motif; other site
65093007119	ATP binding site [chemical binding]; other site
65093007120	Walker B motif; other site
65093007121	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65093007122	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
65093007123	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
65093007124	ATP synthase subunit C; Region: ATP-synt_C; cl00466
65093007125	ATP synthase A chain; Region: ATP-synt_A; cl00413
65093007126	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
65093007127	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
65093007128	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
65093007129	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
65093007130	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
65093007131	gamma subunit interface [polypeptide binding]; other site
65093007132	epsilon subunit interface [polypeptide binding]; other site
65093007133	LBP interface [polypeptide binding]; other site
65093007134	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
65093007135	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65093007136	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
65093007137	alpha subunit interaction interface [polypeptide binding]; other site
65093007138	Walker A motif; other site
65093007139	ATP binding site [chemical binding]; other site
65093007140	Walker B motif; other site
65093007141	inhibitor binding site; inhibition site
65093007142	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65093007143	MgtC family; Region: MgtC; pfam02308
65093007144	lipoyl synthase; Provisional; Region: PRK05481
65093007145	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093007146	FeS/SAM binding site; other site
65093007147	S-layer homology domain; Region: SLH; pfam00395
65093007148	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65093007149	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093007150	putative active site [active]
65093007151	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65093007152	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
65093007153	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
65093007154	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65093007155	Walker A/P-loop; other site
65093007156	ATP binding site [chemical binding]; other site
65093007157	Q-loop/lid; other site
65093007158	ABC transporter signature motif; other site
65093007159	Walker B; other site
65093007160	D-loop; other site
65093007161	H-loop/switch region; other site
65093007162	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65093007163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
65093007164	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093007165	catalytic core [active]
65093007166	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093007167	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093007168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093007169	Walker A/P-loop; other site
65093007170	ATP binding site [chemical binding]; other site
65093007171	Q-loop/lid; other site
65093007172	ABC transporter signature motif; other site
65093007173	Walker B; other site
65093007174	D-loop; other site
65093007175	H-loop/switch region; other site
65093007176	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65093007177	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
65093007178	active site
65093007179	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007181	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
65093007182	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
65093007183	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093007184	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
65093007185	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
65093007186	putative ADP-binding pocket [chemical binding]; other site
65093007187	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
65093007188	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
65093007189	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
65093007190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093007191	dimerization interface [polypeptide binding]; other site
65093007192	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093007193	dimer interface [polypeptide binding]; other site
65093007194	phosphorylation site [posttranslational modification]
65093007195	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007196	ATP binding site [chemical binding]; other site
65093007197	Mg2+ binding site [ion binding]; other site
65093007198	G-X-G motif; other site
65093007199	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093007200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093007201	active site
65093007202	phosphorylation site [posttranslational modification]
65093007203	intermolecular recognition site; other site
65093007204	dimerization interface [polypeptide binding]; other site
65093007205	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093007206	DNA binding site [nucleotide binding]
65093007207	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65093007208	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65093007209	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65093007210	structural tetrad; other site
65093007211	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
65093007212	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
65093007213	intersubunit interface [polypeptide binding]; other site
65093007214	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
65093007215	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
65093007216	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
65093007217	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
65093007218	ABC-ATPase subunit  interface; other site
65093007219	dimer interface [polypeptide binding]; other site
65093007220	putative PBP binding regions; other site
65093007221	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093007222	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
65093007223	ligand binding site [chemical binding]; other site
65093007224	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65093007225	putative switch regulator; other site
65093007226	non-specific DNA interactions [nucleotide binding]; other site
65093007227	DNA binding site [nucleotide binding]
65093007228	sequence specific DNA binding site [nucleotide binding]; other site
65093007229	putative cAMP binding site [chemical binding]; other site
65093007230	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
65093007231	active site
65093007232	substrate binding pocket [chemical binding]; other site
65093007233	dimer interface [polypeptide binding]; other site
65093007234	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65093007235	dimerization interface [polypeptide binding]; other site
65093007236	putative DNA binding site [nucleotide binding]; other site
65093007237	putative Zn2+ binding site [ion binding]; other site
65093007238	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093007239	putative active site [active]
65093007240	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093007241	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
65093007242	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
65093007243	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093007244	active site
65093007245	metal binding site [ion binding]; metal-binding site
65093007246	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
65093007247	metal binding site [ion binding]; metal-binding site
65093007248	Predicted permease; Region: DUF318; cl17795
65093007249	Predicted permease; Region: DUF318; cl17795
65093007250	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
65093007251	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
65093007252	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
65093007253	DNA binding residues [nucleotide binding]
65093007254	dimer interface [polypeptide binding]; other site
65093007255	metal binding site [ion binding]; metal-binding site
65093007256	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
65093007257	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093007258	Ligand Binding Site [chemical binding]; other site
65093007259	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
65093007260	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65093007261	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093007262	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65093007263	cofactor binding site; other site
65093007264	DNA binding site [nucleotide binding]
65093007265	substrate interaction site [chemical binding]; other site
65093007266	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
65093007267	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
65093007268	active site
65093007269	Zn binding site [ion binding]; other site
65093007270	Phycobilisome protein; Region: Phycobilisome; cl08227
65093007271	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
65093007272	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
65093007273	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
65093007274	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
65093007275	Integral membrane protein DUF92; Region: DUF92; pfam01940
65093007276	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65093007277	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
65093007278	active site
65093007279	metal binding site [ion binding]; metal-binding site
65093007280	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
65093007281	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
65093007282	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
65093007283	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
65093007284	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
65093007285	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65093007286	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
65093007287	putative acyl-acceptor binding pocket; other site
65093007288	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
65093007289	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
65093007290	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
65093007291	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
65093007292	active site
65093007293	dimer interface [polypeptide binding]; other site
65093007294	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093007295	active site
65093007296	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65093007297	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65093007298	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
65093007299	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
65093007300	active site
65093007301	hydrophilic channel; other site
65093007302	dimerization interface [polypeptide binding]; other site
65093007303	catalytic residues [active]
65093007304	active site lid [active]
65093007305	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
65093007306	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
65093007307	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093007308	Divergent PAP2 family; Region: DUF212; pfam02681
65093007309	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
65093007310	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
65093007311	substrate binding pocket [chemical binding]; other site
65093007312	chain length determination region; other site
65093007313	substrate-Mg2+ binding site; other site
65093007314	catalytic residues [active]
65093007315	aspartate-rich region 1; other site
65093007316	active site lid residues [active]
65093007317	aspartate-rich region 2; other site
65093007318	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
65093007319	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
65093007320	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
65093007321	homodimer interface [polypeptide binding]; other site
65093007322	NADP binding site [chemical binding]; other site
65093007323	substrate binding site [chemical binding]; other site
65093007324	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
65093007325	C-terminal peptidase (prc); Region: prc; TIGR00225
65093007326	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65093007327	protein binding site [polypeptide binding]; other site
65093007328	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65093007329	Catalytic dyad [active]
65093007330	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
65093007331	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
65093007332	5S rRNA interface [nucleotide binding]; other site
65093007333	CTC domain interface [polypeptide binding]; other site
65093007334	L16 interface [polypeptide binding]; other site
65093007335	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
65093007336	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
65093007337	GDP-binding site [chemical binding]; other site
65093007338	ACT binding site; other site
65093007339	IMP binding site; other site
65093007340	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
65093007341	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
65093007342	active site
65093007343	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65093007344	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
65093007345	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093007346	FeS/SAM binding site; other site
65093007347	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
65093007348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65093007349	TPR motif; other site
65093007350	binding surface
65093007351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093007352	FO synthase subunit 2; Reviewed; Region: PRK07360
65093007353	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093007354	FeS/SAM binding site; other site
65093007355	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
65093007356	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
65093007357	HAMP domain; Region: HAMP; pfam00672
65093007358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093007359	dimer interface [polypeptide binding]; other site
65093007360	phosphorylation site [posttranslational modification]
65093007361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007362	ATP binding site [chemical binding]; other site
65093007363	Mg2+ binding site [ion binding]; other site
65093007364	G-X-G motif; other site
65093007365	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
65093007366	Peptidase family M48; Region: Peptidase_M48; pfam01435
65093007367	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
65093007368	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093007369	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093007370	dimer interface [polypeptide binding]; other site
65093007371	phosphorylation site [posttranslational modification]
65093007372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007373	ATP binding site [chemical binding]; other site
65093007374	Mg2+ binding site [ion binding]; other site
65093007375	G-X-G motif; other site
65093007376	CTP synthetase; Validated; Region: pyrG; PRK05380
65093007377	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
65093007378	Catalytic site [active]
65093007379	active site
65093007380	UTP binding site [chemical binding]; other site
65093007381	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
65093007382	active site
65093007383	putative oxyanion hole; other site
65093007384	catalytic triad [active]
65093007385	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
65093007386	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
65093007387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093007388	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65093007389	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007390	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007391	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007392	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093007395	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65093007396	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
65093007397	DNA-binding interface [nucleotide binding]; DNA binding site
65093007398	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
65093007399	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
65093007400	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
65093007401	23S rRNA binding site [nucleotide binding]; other site
65093007402	L21 binding site [polypeptide binding]; other site
65093007403	L13 binding site [polypeptide binding]; other site
65093007404	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65093007405	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
65093007406	substrate binding pocket [chemical binding]; other site
65093007407	membrane-bound complex binding site; other site
65093007408	hinge residues; other site
65093007409	TPR repeat; Region: TPR_11; pfam13414
65093007410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093007411	binding surface
65093007412	TPR motif; other site
65093007413	TPR repeat; Region: TPR_11; pfam13414
65093007414	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
65093007415	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
65093007416	active site
65093007417	intersubunit interface [polypeptide binding]; other site
65093007418	catalytic residue [active]
65093007419	Rubredoxin; Region: Rubredoxin; pfam00301
65093007420	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
65093007421	iron binding site [ion binding]; other site
65093007422	Ycf48-like protein; Provisional; Region: PRK13684
65093007423	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
65093007424	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
65093007425	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
65093007426	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
65093007427	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
65093007428	argininosuccinate synthase; Provisional; Region: PRK13820
65093007429	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
65093007430	ANP binding site [chemical binding]; other site
65093007431	Substrate Binding Site II [chemical binding]; other site
65093007432	Substrate Binding Site I [chemical binding]; other site
65093007433	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
65093007434	MPN+ (JAMM) motif; other site
65093007435	Zinc-binding site [ion binding]; other site
65093007436	hypothetical protein; Validated; Region: PRK07411
65093007437	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
65093007438	ATP binding site [chemical binding]; other site
65093007439	substrate interface [chemical binding]; other site
65093007440	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
65093007441	active site residue [active]
65093007442	AAA domain; Region: AAA_33; pfam13671
65093007443	AAA domain; Region: AAA_17; pfam13207
65093007444	WYL domain; Region: WYL; pfam13280
65093007445	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
65093007446	active site
65093007447	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
65093007448	active site
65093007449	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
65093007450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007451	S-adenosylmethionine binding site [chemical binding]; other site
65093007452	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
65093007453	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
65093007454	ligand binding site [chemical binding]; other site
65093007455	NAD binding site [chemical binding]; other site
65093007456	dimerization interface [polypeptide binding]; other site
65093007457	catalytic site [active]
65093007458	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
65093007459	putative L-serine binding site [chemical binding]; other site
65093007460	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
65093007461	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093007462	RNA binding surface [nucleotide binding]; other site
65093007463	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
65093007464	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65093007465	Walker A/P-loop; other site
65093007466	ATP binding site [chemical binding]; other site
65093007467	Q-loop/lid; other site
65093007468	ABC transporter signature motif; other site
65093007469	Walker B; other site
65093007470	D-loop; other site
65093007471	H-loop/switch region; other site
65093007472	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
65093007473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65093007474	Walker A/P-loop; other site
65093007475	ATP binding site [chemical binding]; other site
65093007476	Q-loop/lid; other site
65093007477	ABC transporter signature motif; other site
65093007478	Walker B; other site
65093007479	D-loop; other site
65093007480	H-loop/switch region; other site
65093007481	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
65093007482	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
65093007483	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
65093007484	Predicted RNA-binding protein, contains THUMP domain [General function prediction only]; Region: COG1818
65093007485	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
65093007486	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093007487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007488	S-adenosylmethionine binding site [chemical binding]; other site
65093007489	Rhomboid family; Region: Rhomboid; pfam01694
65093007490	Ion channel; Region: Ion_trans_2; pfam07885
65093007491	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65093007492	TrkA-N domain; Region: TrkA_N; pfam02254
65093007493	TrkA-C domain; Region: TrkA_C; pfam02080
65093007494	acetylornithine aminotransferase; Provisional; Region: PRK02627
65093007495	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65093007496	inhibitor-cofactor binding pocket; inhibition site
65093007497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093007498	catalytic residue [active]
65093007499	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
65093007500	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093007501	active site
65093007502	metal binding site [ion binding]; metal-binding site
65093007503	hexamer interface [polypeptide binding]; other site
65093007504	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
65093007505	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
65093007506	domain interfaces; other site
65093007507	active site
65093007508	molecular chaperone DnaK; Provisional; Region: PRK13410
65093007509	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65093007510	nucleotide binding site [chemical binding]; other site
65093007511	NEF interaction site [polypeptide binding]; other site
65093007512	SBD interface [polypeptide binding]; other site
65093007513	chaperone protein DnaJ; Provisional; Region: PRK14299
65093007514	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093007515	HSP70 interaction site [polypeptide binding]; other site
65093007516	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65093007517	substrate binding site [polypeptide binding]; other site
65093007518	dimer interface [polypeptide binding]; other site
65093007519	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
65093007520	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
65093007521	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093007522	ATP binding site [chemical binding]; other site
65093007523	putative Mg++ binding site [ion binding]; other site
65093007524	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093007525	nucleotide binding region [chemical binding]; other site
65093007526	ATP-binding site [chemical binding]; other site
65093007527	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
65093007528	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65093007529	DNA methylase; Region: N6_N4_Mtase; pfam01555
65093007530	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093007531	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
65093007532	Walker A/P-loop; other site
65093007533	ATP binding site [chemical binding]; other site
65093007534	Q-loop/lid; other site
65093007535	ABC transporter signature motif; other site
65093007536	Walker B; other site
65093007537	D-loop; other site
65093007538	H-loop/switch region; other site
65093007539	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
65093007540	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65093007541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093007542	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
65093007543	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
65093007544	iron-sulfur cluster [ion binding]; other site
65093007545	[2Fe-2S] cluster binding site [ion binding]; other site
65093007546	Uncharacterized conserved protein [Function unknown]; Region: COG3349
65093007547	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093007548	putative active site [active]
65093007549	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65093007550	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65093007551	iron-sulfur cluster [ion binding]; other site
65093007552	[2Fe-2S] cluster binding site [ion binding]; other site
65093007553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007554	S-adenosylmethionine binding site [chemical binding]; other site
65093007555	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
65093007556	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093007557	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093007558	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093007559	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093007560	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093007561	Walker A/P-loop; other site
65093007562	ATP binding site [chemical binding]; other site
65093007563	Q-loop/lid; other site
65093007564	ABC transporter signature motif; other site
65093007565	Walker B; other site
65093007566	D-loop; other site
65093007567	H-loop/switch region; other site
65093007568	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
65093007569	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
65093007570	tetramer interface [polypeptide binding]; other site
65093007571	TPP-binding site [chemical binding]; other site
65093007572	heterodimer interface [polypeptide binding]; other site
65093007573	phosphorylation loop region [posttranslational modification]
65093007574	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093007575	HSP70 interaction site [polypeptide binding]; other site
65093007576	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
65093007577	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
65093007578	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
65093007579	Malic enzyme, N-terminal domain; Region: malic; pfam00390
65093007580	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
65093007581	putative NAD(P) binding site [chemical binding]; other site
65093007582	Uncharacterized conserved protein [Function unknown]; Region: COG1434
65093007583	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65093007584	putative active site [active]
65093007585	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
65093007586	intracellular protease, PfpI family; Region: PfpI; TIGR01382
65093007587	proposed catalytic triad [active]
65093007588	conserved cys residue [active]
65093007589	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
65093007590	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65093007591	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
65093007592	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
65093007593	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65093007594	nudix motif; other site
65093007595	ParB-like nuclease domain; Region: ParBc; cl02129
65093007596	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65093007597	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65093007598	dimerization interface [polypeptide binding]; other site
65093007599	DPS ferroxidase diiron center [ion binding]; other site
65093007600	ion pore; other site
65093007601	Phytase; Region: Phytase; cl17685
65093007602	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
65093007603	active site
65093007604	catalytic triad [active]
65093007605	oxyanion hole [active]
65093007606	Phytase; Region: Phytase; cl17685
65093007607	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
65093007608	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
65093007609	Domain of unknown function DUF21; Region: DUF21; pfam01595
65093007610	FOG: CBS domain [General function prediction only]; Region: COG0517
65093007611	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65093007612	proton extrusion protein PcxA; Provisional; Region: PRK02507
65093007613	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
65093007614	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
65093007615	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
65093007616	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
65093007617	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
65093007618	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
65093007619	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
65093007620	Domain of unknown function (DUF309); Region: DUF309; pfam03745
65093007621	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
65093007622	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65093007623	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65093007624	active site
65093007625	metal binding site [ion binding]; metal-binding site
65093007626	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
65093007627	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
65093007628	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65093007629	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
65093007630	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
65093007631	dimer interface [polypeptide binding]; other site
65093007632	putative anticodon binding site; other site
65093007633	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
65093007634	motif 1; other site
65093007635	active site
65093007636	motif 2; other site
65093007637	motif 3; other site
65093007638	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
65093007639	argininosuccinate lyase; Provisional; Region: PRK00855
65093007640	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
65093007641	active sites [active]
65093007642	tetramer interface [polypeptide binding]; other site
65093007643	Stage II sporulation protein; Region: SpoIID; pfam08486
65093007644	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
65093007645	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
65093007646	4Fe-4S binding domain; Region: Fer4; pfam00037
65093007647	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65093007648	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
65093007649	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093007650	catalytic residues [active]
65093007651	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65093007652	protein I interface; other site
65093007653	D2 interface; other site
65093007654	protein T interface; other site
65093007655	chlorophyll binding site; other site
65093007656	beta carotene binding site; other site
65093007657	pheophytin binding site; other site
65093007658	manganese-stabilizing polypeptide interface; other site
65093007659	CP43 interface; other site
65093007660	protein L interface; other site
65093007661	oxygen evolving complex binding site; other site
65093007662	bromide binding site; other site
65093007663	quinone binding site; other site
65093007664	Fe binding site [ion binding]; other site
65093007665	core light harvesting interface; other site
65093007666	cytochrome b559 alpha subunit interface; other site
65093007667	cytochrome c-550 interface; other site
65093007668	protein J interface; other site
65093007669	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
65093007670	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
65093007671	NAD(P) binding site [chemical binding]; other site
65093007672	catalytic residues [active]
65093007673	acetolactate synthase; Reviewed; Region: PRK08322
65093007674	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65093007675	PYR/PP interface [polypeptide binding]; other site
65093007676	dimer interface [polypeptide binding]; other site
65093007677	TPP binding site [chemical binding]; other site
65093007678	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65093007679	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
65093007680	TPP-binding site [chemical binding]; other site
65093007681	dimer interface [polypeptide binding]; other site
65093007682	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
65093007683	pheophytin binding site; other site
65093007684	chlorophyll binding site; other site
65093007685	quinone binding site; other site
65093007686	Fe binding site [ion binding]; other site
65093007687	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
65093007688	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
65093007689	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
65093007690	active site
65093007691	substrate binding site [chemical binding]; other site
65093007692	metal binding site [ion binding]; metal-binding site
65093007693	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
65093007694	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
65093007695	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
65093007696	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
65093007697	dimer interface [polypeptide binding]; other site
65093007698	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
65093007699	active site
65093007700	Fe binding site [ion binding]; other site
65093007701	classical (c) SDRs; Region: SDR_c; cd05233
65093007702	NAD(P) binding site [chemical binding]; other site
65093007703	active site
65093007704	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
65093007705	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
65093007706	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
65093007707	active site
65093007708	dimer interface [polypeptide binding]; other site
65093007709	motif 1; other site
65093007710	motif 2; other site
65093007711	motif 3; other site
65093007712	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
65093007713	anticodon binding site; other site
65093007714	MAPEG family; Region: MAPEG; cl09190
65093007715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
65093007716	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
65093007717	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
65093007718	Predicted membrane protein [Function unknown]; Region: COG2261
65093007719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
65093007720	conserved hypothetical protein; Region: TIGR03492
65093007721	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
65093007722	RimM N-terminal domain; Region: RimM; pfam01782
65093007723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093007724	dimer interface [polypeptide binding]; other site
65093007725	conserved gate region; other site
65093007726	ABC-ATPase subunit interface; other site
65093007727	Peptidase family M48; Region: Peptidase_M48; cl12018
65093007728	Cache domain; Region: Cache_1; pfam02743
65093007729	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
65093007730	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093007731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093007732	putative active site [active]
65093007733	heme pocket [chemical binding]; other site
65093007734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093007735	putative active site [active]
65093007736	heme pocket [chemical binding]; other site
65093007737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093007738	putative active site [active]
65093007739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093007740	heme pocket [chemical binding]; other site
65093007741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093007742	dimer interface [polypeptide binding]; other site
65093007743	phosphorylation site [posttranslational modification]
65093007744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007745	ATP binding site [chemical binding]; other site
65093007746	Mg2+ binding site [ion binding]; other site
65093007747	G-X-G motif; other site
65093007748	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093007749	Response regulator receiver domain; Region: Response_reg; pfam00072
65093007750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093007751	active site
65093007752	phosphorylation site [posttranslational modification]
65093007753	intermolecular recognition site; other site
65093007754	dimerization interface [polypeptide binding]; other site
65093007755	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093007756	putative binding surface; other site
65093007757	active site
65093007758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093007759	Probable transposase; Region: OrfB_IS605; pfam01385
65093007760	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093007761	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093007762	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093007763	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
65093007764	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
65093007765	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
65093007766	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65093007767	substrate binding site [chemical binding]; other site
65093007768	ATP binding site [chemical binding]; other site
65093007769	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
65093007770	Domain of unknown function DUF59; Region: DUF59; pfam01883
65093007771	antiporter inner membrane protein; Provisional; Region: PRK11670
65093007772	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
65093007773	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
65093007774	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
65093007775	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093007776	HSP70 interaction site [polypeptide binding]; other site
65093007777	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
65093007778	Rhomboid family; Region: Rhomboid; pfam01694
65093007779	Predicted membrane protein [Function unknown]; Region: COG4094
65093007780	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
65093007781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65093007782	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
65093007783	putative dimerization interface [polypeptide binding]; other site
65093007784	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093007785	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093007786	active site
65093007787	ATP binding site [chemical binding]; other site
65093007788	substrate binding site [chemical binding]; other site
65093007789	activation loop (A-loop); other site
65093007790	tellurium resistance terB-like protein; Region: terB_like; cd07177
65093007791	metal binding site [ion binding]; metal-binding site
65093007792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
65093007793	Tic20-like protein; Region: Tic20; pfam09685
65093007794	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093007795	putative active site [active]
65093007796	TM2 domain; Region: TM2; cl00984
65093007797	light-harvesting-like protein 3; Provisional; Region: PLN00014
65093007798	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
65093007799	active site
65093007800	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
65093007801	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
65093007802	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
65093007803	active site
65093007804	multimer interface [polypeptide binding]; other site
65093007805	Predicted acyl esterases [General function prediction only]; Region: COG2936
65093007806	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093007807	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
65093007808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
65093007809	Protein of unknown function, DUF482; Region: DUF482; pfam04339
65093007810	Protein of unknown function (DUF751); Region: DUF751; pfam05421
65093007811	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
65093007812	Clp amino terminal domain; Region: Clp_N; pfam02861
65093007813	Clp amino terminal domain; Region: Clp_N; pfam02861
65093007814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093007815	Walker A motif; other site
65093007816	ATP binding site [chemical binding]; other site
65093007817	Walker B motif; other site
65093007818	arginine finger; other site
65093007819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093007820	Walker A motif; other site
65093007821	ATP binding site [chemical binding]; other site
65093007822	Walker B motif; other site
65093007823	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65093007824	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
65093007825	S-layer homology domain; Region: SLH; pfam00395
65093007826	S-layer homology domain; Region: SLH; pfam00395
65093007827	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
65093007828	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
65093007829	SLBB domain; Region: SLBB; pfam10531
65093007830	SLBB domain; Region: SLBB; pfam10531
65093007831	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65093007832	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093007833	Walker A/P-loop; other site
65093007834	ATP binding site [chemical binding]; other site
65093007835	Q-loop/lid; other site
65093007836	ABC transporter signature motif; other site
65093007837	Walker B; other site
65093007838	D-loop; other site
65093007839	H-loop/switch region; other site
65093007840	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093007841	putative active site [active]
65093007842	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093007843	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093007844	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
65093007845	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093007846	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093007847	sulfotransferase; Region: PLN02164
65093007848	TIGR03032 family protein; Region: TIGR03032
65093007849	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093007850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007851	S-adenosylmethionine binding site [chemical binding]; other site
65093007852	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093007853	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
65093007854	NAD(P) binding site [chemical binding]; other site
65093007855	active site
65093007856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007857	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093007858	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093007859	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
65093007860	metal-binding site
65093007861	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
65093007862	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
65093007863	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093007864	active site
65093007865	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007866	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093007867	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
65093007868	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007869	active site
65093007870	Exostosin family; Region: Exostosin; pfam03016
65093007871	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
65093007872	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65093007873	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093007874	putative active site [active]
65093007875	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
65093007876	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007877	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093007878	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093007879	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007880	active site
65093007881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093007882	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007883	active site
65093007884	Protein of unknown function (DUF563); Region: DUF563; pfam04577
65093007885	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093007886	YcfA-like protein; Region: YcfA; cl00752
65093007887	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093007888	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093007889	active site
65093007890	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093007891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007892	S-adenosylmethionine binding site [chemical binding]; other site
65093007893	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
65093007894	trimer interface [polypeptide binding]; other site
65093007895	active site
65093007896	substrate binding site [chemical binding]; other site
65093007897	CoA binding site [chemical binding]; other site
65093007898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093007899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
65093007900	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093007901	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007902	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65093007903	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093007904	active site
65093007905	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093007906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007907	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093007908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093007909	S-adenosylmethionine binding site [chemical binding]; other site
65093007910	Galactose-3-O-sulfotransferase; Region: Gal-3-0_sulfotr; pfam06990
65093007911	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093007912	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007913	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007914	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65093007915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093007916	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
65093007917	putative ADP-binding pocket [chemical binding]; other site
65093007918	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65093007919	putative active site [active]
65093007920	putative acyl transferase; Provisional; Region: PRK10502
65093007921	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
65093007922	putative trimer interface [polypeptide binding]; other site
65093007923	putative active site [active]
65093007924	putative substrate binding site [chemical binding]; other site
65093007925	putative CoA binding site [chemical binding]; other site
65093007926	Predicted permeases [General function prediction only]; Region: COG0701
65093007927	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
65093007928	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
65093007929	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093007930	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093007931	ligand binding site [chemical binding]; other site
65093007932	flexible hinge region; other site
65093007933	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
65093007934	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
65093007935	putative active site [active]
65093007936	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093007937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093007938	Walker A/P-loop; other site
65093007939	ATP binding site [chemical binding]; other site
65093007940	Q-loop/lid; other site
65093007941	ABC transporter signature motif; other site
65093007942	Walker B; other site
65093007943	D-loop; other site
65093007944	H-loop/switch region; other site
65093007945	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65093007946	GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428
65093007947	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093007948	peptide chain release factor 2; Validated; Region: prfB; PRK00578
65093007949	This domain is found in peptide chain release factors; Region: PCRF; smart00937
65093007950	RF-1 domain; Region: RF-1; pfam00472
65093007951	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
65093007952	metal-binding heat shock protein; Provisional; Region: PRK00016
65093007953	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
65093007954	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
65093007955	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
65093007956	Aspartase; Region: Aspartase; cd01357
65093007957	active sites [active]
65093007958	tetramer interface [polypeptide binding]; other site
65093007959	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093007960	putative binding surface; other site
65093007961	active site
65093007962	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65093007963	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093007964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093007965	ATP binding site [chemical binding]; other site
65093007966	Mg2+ binding site [ion binding]; other site
65093007967	G-X-G motif; other site
65093007968	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65093007969	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093007970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093007971	active site
65093007972	phosphorylation site [posttranslational modification]
65093007973	intermolecular recognition site; other site
65093007974	dimerization interface [polypeptide binding]; other site
65093007975	Two component signalling adaptor domain; Region: CheW; smart00260
65093007976	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093007977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093007978	active site
65093007979	phosphorylation site [posttranslational modification]
65093007980	intermolecular recognition site; other site
65093007981	dimerization interface [polypeptide binding]; other site
65093007982	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093007983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093007984	active site
65093007985	phosphorylation site [posttranslational modification]
65093007986	intermolecular recognition site; other site
65093007987	dimerization interface [polypeptide binding]; other site
65093007988	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65093007989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093007990	dimerization interface [polypeptide binding]; other site
65093007991	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093007992	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093007993	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093007994	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093007995	dimer interface [polypeptide binding]; other site
65093007996	putative CheW interface [polypeptide binding]; other site
65093007997	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
65093007998	heme-binding site [chemical binding]; other site
65093007999	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093008000	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093008001	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093008002	metal binding site [ion binding]; metal-binding site
65093008003	active site
65093008004	I-site; other site
65093008005	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
65093008006	Predicted membrane protein [Function unknown]; Region: COG3463
65093008007	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65093008008	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093008009	catalytic residues [active]
65093008010	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
65093008011	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
65093008012	Glycoprotease family; Region: Peptidase_M22; pfam00814
65093008013	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
65093008014	active site
65093008015	intersubunit interface [polypeptide binding]; other site
65093008016	catalytic residue [active]
65093008017	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
65093008018	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
65093008019	intersubunit interface [polypeptide binding]; other site
65093008020	active site
65093008021	zinc binding site [ion binding]; other site
65093008022	Na+ binding site [ion binding]; other site
65093008023	K+ potassium transporter; Region: K_trans; cl15781
65093008024	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
65093008025	active site
65093008026	catalytic residues [active]
65093008027	metal binding site [ion binding]; metal-binding site
65093008028	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093008029	Ligand Binding Site [chemical binding]; other site
65093008030	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093008031	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65093008032	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008033	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008034	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008035	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008036	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008037	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008038	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008039	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008040	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65093008041	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008042	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008043	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008044	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008046	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65093008047	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
65093008048	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65093008049	putative active site [active]
65093008050	putative NTP binding site [chemical binding]; other site
65093008051	putative nucleic acid binding site [nucleotide binding]; other site
65093008052	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65093008053	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093008054	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093008055	active site
65093008056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093008057	Probable transposase; Region: OrfB_IS605; pfam01385
65093008058	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
65093008059	generic binding surface I; other site
65093008060	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
65093008061	putative active site [active]
65093008062	putative catalytic site [active]
65093008063	putative Mg binding site IVb [ion binding]; other site
65093008064	putative phosphate binding site [ion binding]; other site
65093008065	putative DNA binding site [nucleotide binding]; other site
65093008066	putative Mg binding site IVa [ion binding]; other site
65093008067	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
65093008068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008069	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093008070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008071	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65093008072	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65093008073	iron-sulfur cluster [ion binding]; other site
65093008074	[2Fe-2S] cluster binding site [ion binding]; other site
65093008075	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
65093008076	hydrophobic ligand binding site; other site
65093008077	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093008078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008079	active site
65093008080	phosphorylation site [posttranslational modification]
65093008081	intermolecular recognition site; other site
65093008082	dimerization interface [polypeptide binding]; other site
65093008083	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008084	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093008085	putative active site [active]
65093008086	heme pocket [chemical binding]; other site
65093008087	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093008088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008089	putative active site [active]
65093008090	heme pocket [chemical binding]; other site
65093008091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008092	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093008093	putative active site [active]
65093008094	heme pocket [chemical binding]; other site
65093008095	PAS domain S-box; Region: sensory_box; TIGR00229
65093008096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008097	putative active site [active]
65093008098	heme pocket [chemical binding]; other site
65093008099	PAS fold; Region: PAS; pfam00989
65093008100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008101	putative active site [active]
65093008102	heme pocket [chemical binding]; other site
65093008103	PAS domain S-box; Region: sensory_box; TIGR00229
65093008104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008105	PAS fold; Region: PAS_3; pfam08447
65093008106	putative active site [active]
65093008107	heme pocket [chemical binding]; other site
65093008108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008109	PAS domain; Region: PAS_9; pfam13426
65093008110	putative active site [active]
65093008111	heme pocket [chemical binding]; other site
65093008112	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65093008113	Histidine kinase; Region: HisKA_2; pfam07568
65093008114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093008115	ATP binding site [chemical binding]; other site
65093008116	Mg2+ binding site [ion binding]; other site
65093008117	G-X-G motif; other site
65093008118	light-harvesting-like protein 3; Provisional; Region: PLN00014
65093008119	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
65093008120	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
65093008121	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65093008122	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65093008123	substrate binding pocket [chemical binding]; other site
65093008124	membrane-bound complex binding site; other site
65093008125	hinge residues; other site
65093008126	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093008127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008128	active site
65093008129	phosphorylation site [posttranslational modification]
65093008130	intermolecular recognition site; other site
65093008131	dimerization interface [polypeptide binding]; other site
65093008132	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093008133	DNA binding site [nucleotide binding]
65093008134	PAS fold; Region: PAS_3; pfam08447
65093008135	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008136	putative active site [active]
65093008137	heme pocket [chemical binding]; other site
65093008138	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
65093008139	homodimer interface [polypeptide binding]; other site
65093008140	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
65093008141	active site pocket [active]
65093008142	putative phosphoketolase; Provisional; Region: PRK05261
65093008143	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
65093008144	TPP-binding site; other site
65093008145	XFP C-terminal domain; Region: XFP_C; pfam09363
65093008146	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65093008147	catalytic core [active]
65093008148	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093008149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093008150	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093008151	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
65093008152	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093008153	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093008154	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65093008155	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65093008156	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65093008157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65093008158	substrate binding pocket [chemical binding]; other site
65093008159	membrane-bound complex binding site; other site
65093008160	hinge residues; other site
65093008161	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
65093008162	Family of unknown function (DUF490); Region: DUF490; pfam04357
65093008163	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
65093008164	Sodium Bile acid symporter family; Region: SBF; cl17470
65093008165	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
65093008166	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
65093008167	Sulfatase; Region: Sulfatase; pfam00884
65093008168	CNH domain; Region: CNH; cl02434
65093008169	Domain of unknown function (DUF202); Region: DUF202; cl09954
65093008170	Domain of unknown function (DUF202); Region: DUF202; cl09954
65093008171	Domain of unknown function (DUF202); Region: DUF202; cl09954
65093008172	Domain of unknown function (DUF202); Region: DUF202; cl09954
65093008173	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
65093008174	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
65093008175	Predicted membrane protein [Function unknown]; Region: COG4803
65093008176	Sodium Bile acid symporter family; Region: SBF; cl17470
65093008177	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
65093008178	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
65093008179	Sulfatase; Region: Sulfatase; pfam00884
65093008180	Sulfatase; Region: Sulfatase; cl17466
65093008181	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
65093008182	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65093008183	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65093008184	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
65093008185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093008186	TPR motif; other site
65093008187	binding surface
65093008188	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093008189	DNA binding residues [nucleotide binding]
65093008190	dimerization interface [polypeptide binding]; other site
65093008191	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093008192	Surface antigen; Region: Bac_surface_Ag; pfam01103
65093008193	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
65093008194	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65093008195	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65093008196	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
65093008197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093008198	dimer interface [polypeptide binding]; other site
65093008199	conserved gate region; other site
65093008200	putative PBP binding loops; other site
65093008201	ABC-ATPase subunit interface; other site
65093008202	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65093008203	active site
65093008204	catalytic site [active]
65093008205	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65093008206	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
65093008207	HSP70 interaction site [polypeptide binding]; other site
65093008208	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
65093008209	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
65093008210	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
65093008211	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
65093008212	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
65093008213	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
65093008214	cobalamin binding residues [chemical binding]; other site
65093008215	putative BtuC binding residues; other site
65093008216	dimer interface [polypeptide binding]; other site
65093008217	Transcriptional regulator [Transcription]; Region: LytR; COG1316
65093008218	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
65093008219	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65093008220	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65093008221	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65093008222	Cytochrome P450; Region: p450; pfam00067
65093008223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093008224	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093008225	Probable transposase; Region: OrfB_IS605; pfam01385
65093008226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008227	Walker A motif; other site
65093008228	ATP binding site [chemical binding]; other site
65093008229	Walker B motif; other site
65093008230	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093008231	protein-splicing catalytic site; other site
65093008232	thioester formation/cholesterol transfer; other site
65093008233	Pretoxin HINT domain; Region: PT-HINT; pfam07591
65093008234	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
65093008235	DNA polymerase III subunit delta'; Validated; Region: PRK08485
65093008236	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
65093008237	hypothetical protein; Provisional; Region: PRK13686
65093008238	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65093008239	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
65093008240	EamA-like transporter family; Region: EamA; pfam00892
65093008241	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65093008242	Spore germination protein [General function prediction only]; Region: COG5401
65093008243	Sporulation and spore germination; Region: Germane; smart00909
65093008244	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
65093008245	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
65093008246	carboxyltransferase (CT) interaction site; other site
65093008247	biotinylation site [posttranslational modification]; other site
65093008248	elongation factor P; Validated; Region: PRK00529
65093008249	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
65093008250	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
65093008251	RNA binding site [nucleotide binding]; other site
65093008252	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
65093008253	RNA binding site [nucleotide binding]; other site
65093008254	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
65093008255	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
65093008256	active site
65093008257	HIGH motif; other site
65093008258	dimer interface [polypeptide binding]; other site
65093008259	KMSKS motif; other site
65093008260	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093008261	RNA binding surface [nucleotide binding]; other site
65093008262	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
65093008263	Uncharacterized conserved protein [Function unknown]; Region: COG0432
65093008264	cell division protein; Validated; Region: ftsH; CHL00176
65093008265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008266	Walker A motif; other site
65093008267	ATP binding site [chemical binding]; other site
65093008268	Walker B motif; other site
65093008269	arginine finger; other site
65093008270	Peptidase family M41; Region: Peptidase_M41; pfam01434
65093008271	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
65093008272	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
65093008273	quinone interaction residues [chemical binding]; other site
65093008274	active site
65093008275	catalytic residues [active]
65093008276	FMN binding site [chemical binding]; other site
65093008277	substrate binding site [chemical binding]; other site
65093008278	M28 Zn-Peptidases; Region: M28_like_1; cd05640
65093008279	Peptidase family M28; Region: Peptidase_M28; pfam04389
65093008280	metal binding site [ion binding]; metal-binding site
65093008281	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65093008282	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093008283	catalytic loop [active]
65093008284	iron binding site [ion binding]; other site
65093008285	Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609
65093008286	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093008287	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
65093008288	putative active site [active]
65093008289	dimerization interface [polypeptide binding]; other site
65093008290	putative tRNAtyr binding site [nucleotide binding]; other site
65093008291	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
65093008292	MOSC domain; Region: MOSC; pfam03473
65093008293	Repair protein; Region: Repair_PSII; pfam04536
65093008294	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
65093008295	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093008296	Coenzyme A binding pocket [chemical binding]; other site
65093008297	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
65093008298	EVE domain; Region: EVE; cl00728
65093008299	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093008300	FOG: CBS domain [General function prediction only]; Region: COG0517
65093008301	FOG: CBS domain [General function prediction only]; Region: COG0517
65093008302	FOG: CBS domain [General function prediction only]; Region: COG0517
65093008303	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
65093008304	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65093008305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093008306	putative active site [active]
65093008307	heme pocket [chemical binding]; other site
65093008308	GAF domain; Region: GAF; pfam01590
65093008309	GAF domain; Region: GAF_2; pfam13185
65093008310	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093008311	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093008312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093008313	dimer interface [polypeptide binding]; other site
65093008314	phosphorylation site [posttranslational modification]
65093008315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093008316	ATP binding site [chemical binding]; other site
65093008317	Mg2+ binding site [ion binding]; other site
65093008318	G-X-G motif; other site
65093008319	Response regulator receiver domain; Region: Response_reg; pfam00072
65093008320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008321	active site
65093008322	phosphorylation site [posttranslational modification]
65093008323	intermolecular recognition site; other site
65093008324	dimerization interface [polypeptide binding]; other site
65093008325	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093008326	putative binding surface; other site
65093008327	active site
65093008328	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
65093008329	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
65093008330	active site
65093008331	(T/H)XGH motif; other site
65093008332	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
65093008333	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
65093008334	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
65093008335	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
65093008336	30S subunit binding site; other site
65093008337	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
65093008338	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
65093008339	NAD binding site [chemical binding]; other site
65093008340	homotetramer interface [polypeptide binding]; other site
65093008341	homodimer interface [polypeptide binding]; other site
65093008342	substrate binding site [chemical binding]; other site
65093008343	active site
65093008344	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
65093008345	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
65093008346	putative active site pocket [active]
65093008347	4-fold oligomerization interface [polypeptide binding]; other site
65093008348	metal binding residues [ion binding]; metal-binding site
65093008349	3-fold/trimer interface [polypeptide binding]; other site
65093008350	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
65093008351	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
65093008352	dimerization interface [polypeptide binding]; other site
65093008353	ATP binding site [chemical binding]; other site
65093008354	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
65093008355	dimerization interface [polypeptide binding]; other site
65093008356	ATP binding site [chemical binding]; other site
65093008357	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
65093008358	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
65093008359	NAD binding site [chemical binding]; other site
65093008360	substrate binding site [chemical binding]; other site
65093008361	catalytic Zn binding site [ion binding]; other site
65093008362	tetramer interface [polypeptide binding]; other site
65093008363	structural Zn binding site [ion binding]; other site
65093008364	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
65093008365	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
65093008366	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
65093008367	YcfA-like protein; Region: YcfA; pfam07927
65093008368	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
65093008369	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
65093008370	Ca binding site [ion binding]; other site
65093008371	active site
65093008372	catalytic site [active]
65093008373	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
65093008374	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
65093008375	Chromate transporter; Region: Chromate_transp; pfam02417
65093008376	enolase; Provisional; Region: eno; PRK00077
65093008377	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
65093008378	dimer interface [polypeptide binding]; other site
65093008379	metal binding site [ion binding]; metal-binding site
65093008380	substrate binding pocket [chemical binding]; other site
65093008381	O-succinylbenzoate synthase; Provisional; Region: PRK02714
65093008382	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
65093008383	active site
65093008384	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65093008385	oligomeric interface; other site
65093008386	putative active site [active]
65093008387	homodimer interface [polypeptide binding]; other site
65093008388	Response regulator receiver domain; Region: Response_reg; pfam00072
65093008389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008390	active site
65093008391	phosphorylation site [posttranslational modification]
65093008392	intermolecular recognition site; other site
65093008393	dimerization interface [polypeptide binding]; other site
65093008394	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
65093008395	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
65093008396	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
65093008397	putative hydrophobic ligand binding site [chemical binding]; other site
65093008398	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
65093008399	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093008400	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65093008401	protein I interface; other site
65093008402	D2 interface; other site
65093008403	protein T interface; other site
65093008404	chlorophyll binding site; other site
65093008405	beta carotene binding site; other site
65093008406	pheophytin binding site; other site
65093008407	manganese-stabilizing polypeptide interface; other site
65093008408	CP43 interface; other site
65093008409	protein L interface; other site
65093008410	oxygen evolving complex binding site; other site
65093008411	bromide binding site; other site
65093008412	quinone binding site; other site
65093008413	Fe binding site [ion binding]; other site
65093008414	core light harvesting interface; other site
65093008415	cytochrome b559 alpha subunit interface; other site
65093008416	cytochrome c-550 interface; other site
65093008417	protein J interface; other site
65093008418	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
65093008419	nucleotide binding site/active site [active]
65093008420	HIT family signature motif; other site
65093008421	catalytic residue [active]
65093008422	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65093008423	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65093008424	catalytic triad [active]
65093008425	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
65093008426	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
65093008427	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
65093008428	active site
65093008429	substrate binding site [chemical binding]; other site
65093008430	ATP binding site [chemical binding]; other site
65093008431	Haemolytic domain; Region: Haemolytic; pfam01809
65093008432	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
65093008433	putative ADP-binding pocket [chemical binding]; other site
65093008434	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093008435	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
65093008436	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65093008437	putative ADP-binding pocket [chemical binding]; other site
65093008438	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
65093008439	DHH family; Region: DHH; pfam01368
65093008440	DHHA1 domain; Region: DHHA1; pfam02272
65093008441	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093008442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008443	active site
65093008444	phosphorylation site [posttranslational modification]
65093008445	intermolecular recognition site; other site
65093008446	dimerization interface [polypeptide binding]; other site
65093008447	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093008448	DNA binding site [nucleotide binding]
65093008449	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
65093008450	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008451	putative active site [active]
65093008452	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65093008453	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
65093008454	active site
65093008455	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093008456	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093008457	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093008458	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093008459	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093008460	active site
65093008461	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65093008462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093008463	S-adenosylmethionine binding site [chemical binding]; other site
65093008464	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65093008465	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65093008466	active site
65093008467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65093008468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093008469	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008470	putative active site [active]
65093008471	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008472	putative active site [active]
65093008473	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008474	putative active site [active]
65093008475	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008476	putative active site [active]
65093008477	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093008478	putative active site [active]
65093008479	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65093008480	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65093008481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093008482	Walker A/P-loop; other site
65093008483	ATP binding site [chemical binding]; other site
65093008484	Q-loop/lid; other site
65093008485	ABC transporter signature motif; other site
65093008486	Walker B; other site
65093008487	D-loop; other site
65093008488	H-loop/switch region; other site
65093008489	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65093008490	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65093008491	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
65093008492	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65093008493	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65093008494	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093008495	putative active site [active]
65093008496	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
65093008497	PemK-like protein; Region: PemK; pfam02452
65093008498	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093008499	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
65093008500	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093008501	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
65093008502	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
65093008503	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093008504	ATP binding site [chemical binding]; other site
65093008505	putative Mg++ binding site [ion binding]; other site
65093008506	Protein of unknown function DUF45; Region: DUF45; pfam01863
65093008507	DNA-sulfur modification-associated; Region: DndB; pfam14072
65093008508	hypothetical protein; Provisional; Region: PRK06850
65093008509	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
65093008510	Active Sites [active]
65093008511	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
65093008512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093008513	Walker A/P-loop; other site
65093008514	ATP binding site [chemical binding]; other site
65093008515	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
65093008516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093008517	ABC transporter signature motif; other site
65093008518	Walker B; other site
65093008519	D-loop; other site
65093008520	H-loop/switch region; other site
65093008521	S-adenosylmethionine synthetase; Validated; Region: PRK05250
65093008522	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
65093008523	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
65093008524	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
65093008525	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65093008526	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
65093008527	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65093008528	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65093008529	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093008530	motif II; other site
65093008531	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65093008532	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093008533	phosphopeptide binding site; other site
65093008534	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093008535	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
65093008536	glutaminase A; Region: Gln_ase; TIGR03814
65093008537	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
65093008538	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093008539	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
65093008540	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
65093008541	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
65093008542	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
65093008543	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
65093008544	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65093008545	catalytic loop [active]
65093008546	iron binding site [ion binding]; other site
65093008547	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
65093008548	4Fe-4S binding domain; Region: Fer4; pfam00037
65093008549	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65093008550	dimer interface [polypeptide binding]; other site
65093008551	[2Fe-2S] cluster binding site [ion binding]; other site
65093008552	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
65093008553	Y-family of DNA polymerases; Region: PolY; cl12025
65093008554	SLBB domain; Region: SLBB; pfam10531
65093008555	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
65093008556	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
65093008557	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
65093008558	putative dimer interface [polypeptide binding]; other site
65093008559	[2Fe-2S] cluster binding site [ion binding]; other site
65093008560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093008561	Probable transposase; Region: OrfB_IS605; pfam01385
65093008562	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093008563	Uncharacterized conserved protein [Function unknown]; Region: COG2006
65093008564	Domain of unknown function (DUF362); Region: DUF362; pfam04015
65093008565	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
65093008566	PemK-like protein; Region: PemK; pfam02452
65093008567	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093008568	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093008569	anthranilate synthase component I-like protein; Validated; Region: PRK05940
65093008570	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65093008571	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
65093008572	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65093008573	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65093008574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093008575	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65093008576	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093008577	DNA binding residues [nucleotide binding]
65093008578	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
65093008579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093008580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
65093008581	Coenzyme A binding pocket [chemical binding]; other site
65093008582	Uncharacterized conserved protein [Function unknown]; Region: COG2928
65093008583	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
65093008584	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
65093008585	putative active site [active]
65093008586	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093008587	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093008588	phosphopeptide binding site; other site
65093008589	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
65093008590	BCCT family transporter; Region: BCCT; pfam02028
65093008591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093008592	Ligand Binding Site [chemical binding]; other site
65093008593	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093008594	Ligand Binding Site [chemical binding]; other site
65093008595	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
65093008596	active site
65093008597	DNA binding site [nucleotide binding]
65093008598	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
65093008599	nickel binding site [ion binding]; other site
65093008600	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
65093008601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
65093008602	RNA methyltransferase, RsmE family; Region: TIGR00046
65093008603	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
65093008604	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
65093008605	interchain domain interface [polypeptide binding]; other site
65093008606	intrachain domain interface; other site
65093008607	Qi binding site; other site
65093008608	Qo binding site; other site
65093008609	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
65093008610	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
65093008611	Qi binding site; other site
65093008612	intrachain domain interface; other site
65093008613	interchain domain interface [polypeptide binding]; other site
65093008614	heme bH binding site [chemical binding]; other site
65093008615	heme bL binding site [chemical binding]; other site
65093008616	Qo binding site; other site
65093008617	carboxyl-terminal processing protease; Provisional; Region: PLN00049
65093008618	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
65093008619	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65093008620	protein binding site [polypeptide binding]; other site
65093008621	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65093008622	Catalytic dyad [active]
65093008623	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
65093008624	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
65093008625	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093008626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008627	active site
65093008628	phosphorylation site [posttranslational modification]
65093008629	intermolecular recognition site; other site
65093008630	dimerization interface [polypeptide binding]; other site
65093008631	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093008632	DNA binding site [nucleotide binding]
65093008633	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
65093008634	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
65093008635	active site
65093008636	Riboflavin kinase; Region: Flavokinase; pfam01687
65093008637	MoxR-like ATPases [General function prediction only]; Region: COG0714
65093008638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008639	Walker A motif; other site
65093008640	ATP binding site [chemical binding]; other site
65093008641	Walker B motif; other site
65093008642	arginine finger; other site
65093008643	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
65093008644	EamA-like transporter family; Region: EamA; pfam00892
65093008645	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
65093008646	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
65093008647	NAD binding site [chemical binding]; other site
65093008648	homodimer interface [polypeptide binding]; other site
65093008649	active site
65093008650	substrate binding site [chemical binding]; other site
65093008651	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
65093008652	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
65093008653	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
65093008654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093008655	S-adenosylmethionine binding site [chemical binding]; other site
65093008656	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65093008657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093008658	Coenzyme A binding pocket [chemical binding]; other site
65093008659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
65093008660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65093008661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
65093008662	dimerization interface [polypeptide binding]; other site
65093008663	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
65093008664	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65093008665	Catalytic site [active]
65093008666	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
65093008667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008668	Walker A motif; other site
65093008669	ATP binding site [chemical binding]; other site
65093008670	Walker B motif; other site
65093008671	mercuric reductase; Validated; Region: PRK06370
65093008672	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093008673	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093008674	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65093008675	arginine decarboxylase; Provisional; Region: PRK05354
65093008676	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
65093008677	active site
65093008678	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65093008679	catalytic residues [active]
65093008680	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
65093008681	Response regulator receiver domain; Region: Response_reg; pfam00072
65093008682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008683	active site
65093008684	phosphorylation site [posttranslational modification]
65093008685	intermolecular recognition site; other site
65093008686	dimerization interface [polypeptide binding]; other site
65093008687	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
65093008688	geranylgeranyl reductase; Region: ChlP; TIGR02028
65093008689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093008690	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65093008691	GrpE; Region: GrpE; pfam01025
65093008692	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
65093008693	dimer interface [polypeptide binding]; other site
65093008694	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65093008695	molecular chaperone DnaK; Provisional; Region: PRK13411
65093008696	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65093008697	nucleotide binding site [chemical binding]; other site
65093008698	NEF interaction site [polypeptide binding]; other site
65093008699	SBD interface [polypeptide binding]; other site
65093008700	chaperone protein DnaJ; Provisional; Region: PRK14293
65093008701	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65093008702	HSP70 interaction site [polypeptide binding]; other site
65093008703	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
65093008704	substrate binding site [polypeptide binding]; other site
65093008705	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
65093008706	Zn binding sites [ion binding]; other site
65093008707	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65093008708	dimer interface [polypeptide binding]; other site
65093008709	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
65093008710	CPxP  motif; other site
65093008711	Predicted transcriptional regulators [Transcription]; Region: COG1695
65093008712	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
65093008713	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65093008714	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093008715	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093008716	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
65093008717	Protein export membrane protein; Region: SecD_SecF; cl14618
65093008718	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093008719	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093008720	EamA-like transporter family; Region: EamA; pfam00892
65093008721	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
65093008722	EamA-like transporter family; Region: EamA; pfam00892
65093008723	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
65093008724	Protein of function (DUF2518); Region: DUF2518; pfam10726
65093008725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
65093008726	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
65093008727	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
65093008728	active site
65093008729	HIGH motif; other site
65093008730	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
65093008731	KMSKS motif; other site
65093008732	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
65093008733	tRNA binding surface [nucleotide binding]; other site
65093008734	anticodon binding site; other site
65093008735	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
65093008736	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
65093008737	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65093008738	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
65093008739	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
65093008740	substrate binding site [chemical binding]; other site
65093008741	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
65093008742	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
65093008743	substrate binding site [chemical binding]; other site
65093008744	ligand binding site [chemical binding]; other site
65093008745	gamma-glutamyl kinase; Provisional; Region: PRK05429
65093008746	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
65093008747	nucleotide binding site [chemical binding]; other site
65093008748	homotetrameric interface [polypeptide binding]; other site
65093008749	putative phosphate binding site [ion binding]; other site
65093008750	putative allosteric binding site; other site
65093008751	PUA domain; Region: PUA; pfam01472
65093008752	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
65093008753	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
65093008754	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
65093008755	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
65093008756	catalytic residues [active]
65093008757	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
65093008758	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
65093008759	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
65093008760	dimerization interface [polypeptide binding]; other site
65093008761	active site
65093008762	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
65093008763	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
65093008764	PhoU domain; Region: PhoU; pfam01895
65093008765	PhoU domain; Region: PhoU; pfam01895
65093008766	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65093008767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093008768	dimer interface [polypeptide binding]; other site
65093008769	phosphorylation site [posttranslational modification]
65093008770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093008771	ATP binding site [chemical binding]; other site
65093008772	Mg2+ binding site [ion binding]; other site
65093008773	G-X-G motif; other site
65093008774	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65093008775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008776	active site
65093008777	phosphorylation site [posttranslational modification]
65093008778	intermolecular recognition site; other site
65093008779	dimerization interface [polypeptide binding]; other site
65093008780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093008781	DNA binding site [nucleotide binding]
65093008782	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
65093008783	DNA repair protein RadA; Provisional; Region: PRK11823
65093008784	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
65093008785	Walker A motif/ATP binding site; other site
65093008786	ATP binding site [chemical binding]; other site
65093008787	Walker B motif; other site
65093008788	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
65093008789	Ycf27; Reviewed; Region: orf27; CHL00148
65093008790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093008791	active site
65093008792	phosphorylation site [posttranslational modification]
65093008793	intermolecular recognition site; other site
65093008794	dimerization interface [polypeptide binding]; other site
65093008795	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65093008796	DNA binding site [nucleotide binding]
65093008797	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
65093008798	GAF domain; Region: GAF_2; pfam13185
65093008799	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
65093008800	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
65093008801	catalytic motif [active]
65093008802	Zn binding site [ion binding]; other site
65093008803	RibD C-terminal domain; Region: RibD_C; cl17279
65093008804	pyrophosphatase PpaX; Provisional; Region: PRK13288
65093008805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093008806	motif II; other site
65093008807	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
65093008808	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65093008809	metal ion-dependent adhesion site (MIDAS); other site
65093008810	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
65093008811	ribosomal protein L3; Validated; Region: rpl3; CHL00143
65093008812	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
65093008813	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
65093008814	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
65093008815	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
65093008816	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
65093008817	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
65093008818	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
65093008819	putative translocon binding site; other site
65093008820	protein-rRNA interface [nucleotide binding]; other site
65093008821	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
65093008822	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
65093008823	G-X-X-G motif; other site
65093008824	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
65093008825	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
65093008826	23S rRNA interface [nucleotide binding]; other site
65093008827	5S rRNA interface [nucleotide binding]; other site
65093008828	putative antibiotic binding site [chemical binding]; other site
65093008829	L25 interface [polypeptide binding]; other site
65093008830	L27 interface [polypeptide binding]; other site
65093008831	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
65093008832	23S rRNA interface [nucleotide binding]; other site
65093008833	putative translocon interaction site; other site
65093008834	signal recognition particle (SRP54) interaction site; other site
65093008835	L23 interface [polypeptide binding]; other site
65093008836	trigger factor interaction site; other site
65093008837	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
65093008838	ribosomal protein L14; Region: rpl14; CHL00057
65093008839	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
65093008840	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
65093008841	RNA binding site [nucleotide binding]; other site
65093008842	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
65093008843	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
65093008844	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
65093008845	ribosomal protein S8; Region: rps8; CHL00042
65093008846	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
65093008847	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
65093008848	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
65093008849	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
65093008850	23S rRNA interface [nucleotide binding]; other site
65093008851	L21e interface [polypeptide binding]; other site
65093008852	5S rRNA interface [nucleotide binding]; other site
65093008853	L27 interface [polypeptide binding]; other site
65093008854	L5 interface [polypeptide binding]; other site
65093008855	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
65093008856	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
65093008857	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
65093008858	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
65093008859	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
65093008860	SecY translocase; Region: SecY; pfam00344
65093008861	adenylate kinase; Reviewed; Region: adk; PRK00279
65093008862	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
65093008863	AMP-binding site [chemical binding]; other site
65093008864	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
65093008865	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
65093008866	rRNA binding site [nucleotide binding]; other site
65093008867	predicted 30S ribosome binding site; other site
65093008868	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
65093008869	30S ribosomal protein S13; Region: bact_S13; TIGR03631
65093008870	30S ribosomal protein S11; Validated; Region: PRK05309
65093008871	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
65093008872	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
65093008873	alphaNTD homodimer interface [polypeptide binding]; other site
65093008874	alphaNTD - beta interaction site [polypeptide binding]; other site
65093008875	alphaNTD - beta' interaction site [polypeptide binding]; other site
65093008876	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
65093008877	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
65093008878	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
65093008879	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
65093008880	dimerization interface 3.5A [polypeptide binding]; other site
65093008881	active site
65093008882	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
65093008883	23S rRNA interface [nucleotide binding]; other site
65093008884	L3 interface [polypeptide binding]; other site
65093008885	ribosomal protein S9; Region: rps9; CHL00079
65093008886	ribosomal protein L31; Validated; Region: rpl31; CHL00136
65093008887	peptide chain release factor 1; Validated; Region: prfA; PRK00591
65093008888	This domain is found in peptide chain release factors; Region: PCRF; smart00937
65093008889	RF-1 domain; Region: RF-1; pfam00472
65093008890	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
65093008891	phosphoglyceromutase; Provisional; Region: PRK05434
65093008892	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
65093008893	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093008894	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65093008895	cofactor binding site; other site
65093008896	DNA binding site [nucleotide binding]
65093008897	substrate interaction site [chemical binding]; other site
65093008898	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
65093008899	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
65093008900	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
65093008901	substrate binding pocket [chemical binding]; other site
65093008902	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
65093008903	B12 binding site [chemical binding]; other site
65093008904	cobalt ligand [ion binding]; other site
65093008905	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
65093008906	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65093008907	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65093008908	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
65093008909	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
65093008910	putative active site [active]
65093008911	metal binding site [ion binding]; metal-binding site
65093008912	aspartate aminotransferase; Provisional; Region: PRK05942
65093008913	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093008914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093008915	homodimer interface [polypeptide binding]; other site
65093008916	catalytic residue [active]
65093008917	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
65093008918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093008919	S-adenosylmethionine binding site [chemical binding]; other site
65093008920	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
65093008921	ribonucleoside-diphosphate reductase subunit alpha; Provisional; Region: nrdA; PHA02572
65093008922	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65093008923	YcfA-like protein; Region: YcfA; pfam07927
65093008924	T5orf172 domain; Region: T5orf172; pfam10544
65093008925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
65093008926	5-oxoprolinase; Region: PLN02666
65093008927	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
65093008928	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
65093008929	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
65093008930	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093008931	cofactor binding site; other site
65093008932	DNA binding site [nucleotide binding]
65093008933	substrate interaction site [chemical binding]; other site
65093008934	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093008935	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
65093008936	Clp amino terminal domain; Region: Clp_N; pfam02861
65093008937	Clp amino terminal domain; Region: Clp_N; pfam02861
65093008938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008939	Walker A motif; other site
65093008940	ATP binding site [chemical binding]; other site
65093008941	Walker B motif; other site
65093008942	arginine finger; other site
65093008943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093008944	Walker A motif; other site
65093008945	ATP binding site [chemical binding]; other site
65093008946	Walker B motif; other site
65093008947	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65093008948	Predicted membrane protein [Function unknown]; Region: COG2119
65093008949	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
65093008950	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
65093008951	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
65093008952	substrate binding site [chemical binding]; other site
65093008953	oxyanion hole (OAH) forming residues; other site
65093008954	trimer interface [polypeptide binding]; other site
65093008955	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65093008956	SnoaL-like domain; Region: SnoaL_2; pfam12680
65093008957	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
65093008958	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093008959	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
65093008960	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
65093008961	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
65093008962	putative active site [active]
65093008963	catalytic site [active]
65093008964	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
65093008965	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
65093008966	putative catalytic cysteine [active]
65093008967	putative hydrolase; Provisional; Region: PRK11460
65093008968	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
65093008969	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
65093008970	active site
65093008971	dimer interface [polypeptide binding]; other site
65093008972	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
65093008973	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
65093008974	homodimer interface [polypeptide binding]; other site
65093008975	metal binding site [ion binding]; metal-binding site
65093008976	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
65093008977	homodimer interface [polypeptide binding]; other site
65093008978	active site
65093008979	putative chemical substrate binding site [chemical binding]; other site
65093008980	metal binding site [ion binding]; metal-binding site
65093008981	Predicted membrane protein [Function unknown]; Region: COG2259
65093008982	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
65093008983	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65093008984	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
65093008985	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093008986	ATP binding site [chemical binding]; other site
65093008987	putative Mg++ binding site [ion binding]; other site
65093008988	helicase superfamily c-terminal domain; Region: HELICc; smart00490
65093008989	ATP-binding site [chemical binding]; other site
65093008990	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
65093008991	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65093008992	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093008993	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65093008994	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008995	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65093008996	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008997	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093008998	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65093008999	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65093009000	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65093009001	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
65093009002	Phycobilisome protein; Region: Phycobilisome; cl08227
65093009003	CpeS-like protein; Region: CpeS; pfam09367
65093009004	cell division protein MukB; Provisional; Region: mukB; PRK04863
65093009005	CpeS-like protein; Region: CpeS; pfam09367
65093009006	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
65093009007	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
65093009008	purine monophosphate binding site [chemical binding]; other site
65093009009	dimer interface [polypeptide binding]; other site
65093009010	putative catalytic residues [active]
65093009011	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
65093009012	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
65093009013	Response regulator receiver domain; Region: Response_reg; pfam00072
65093009014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093009015	active site
65093009016	phosphorylation site [posttranslational modification]
65093009017	intermolecular recognition site; other site
65093009018	dimerization interface [polypeptide binding]; other site
65093009019	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093009020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093009021	metal binding site [ion binding]; metal-binding site
65093009022	active site
65093009023	I-site; other site
65093009024	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
65093009025	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
65093009026	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
65093009027	Ligand binding site; other site
65093009028	Putative Catalytic site; other site
65093009029	DXD motif; other site
65093009030	Predicted membrane protein [Function unknown]; Region: COG2259
65093009031	Cytochrome c; Region: Cytochrom_C; cl11414
65093009032	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65093009033	Bacterial SH3 domain; Region: SH3_3; pfam08239
65093009034	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
65093009035	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
65093009036	active site
65093009037	metal binding site [ion binding]; metal-binding site
65093009038	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
65093009039	HEAT repeats; Region: HEAT_2; pfam13646
65093009040	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65093009041	pyruvate kinase; Provisional; Region: PRK06354
65093009042	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
65093009043	domain interfaces; other site
65093009044	active site
65093009045	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
65093009046	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
65093009047	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
65093009048	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
65093009049	Ca binding site [ion binding]; other site
65093009050	active site
65093009051	catalytic site [active]
65093009052	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
65093009053	alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515
65093009054	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65093009055	active site
65093009056	catalytic site [active]
65093009057	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65093009058	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65093009059	active site
65093009060	catalytic site [active]
65093009061	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
65093009062	DHH family; Region: DHH; pfam01368
65093009063	FOG: CBS domain [General function prediction only]; Region: COG0517
65093009064	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
65093009065	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
65093009066	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
65093009067	active site
65093009068	NTP binding site [chemical binding]; other site
65093009069	metal binding triad [ion binding]; metal-binding site
65093009070	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
65093009071	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
65093009072	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65093009073	dimerization interface [polypeptide binding]; other site
65093009074	putative DNA binding site [nucleotide binding]; other site
65093009075	putative Zn2+ binding site [ion binding]; other site
65093009076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093009077	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093009078	Probable transposase; Region: OrfB_IS605; pfam01385
65093009079	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093009080	HAS barrel domain; Region: HAS-barrel; pfam09378
65093009081	HerA helicase [Replication, recombination, and repair]; Region: COG0433
65093009082	Domain of unknown function DUF87; Region: DUF87; pfam01935
65093009083	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65093009084	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65093009085	Walker A/P-loop; other site
65093009086	ATP binding site [chemical binding]; other site
65093009087	Q-loop/lid; other site
65093009088	ABC transporter signature motif; other site
65093009089	Walker B; other site
65093009090	D-loop; other site
65093009091	H-loop/switch region; other site
65093009092	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
65093009093	cobalt transport protein CbiN; Provisional; Region: PRK02898
65093009094	cobalt transport protein CbiM; Validated; Region: PRK08319
65093009095	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
65093009096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093009097	AAA domain; Region: AAA_33; pfam13671
65093009098	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65093009099	active site
65093009100	Walker A/P-loop; other site
65093009101	ATP binding site [chemical binding]; other site
65093009102	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65093009103	active site
65093009104	metal binding site [ion binding]; metal-binding site
65093009105	RNA ligase; Region: RNA_lig_T4_1; pfam09511
65093009106	2-isopropylmalate synthase; Validated; Region: PRK00915
65093009107	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
65093009108	active site
65093009109	catalytic residues [active]
65093009110	metal binding site [ion binding]; metal-binding site
65093009111	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
65093009112	LabA_like proteins; Region: LabA; cd10911
65093009113	Uncharacterized conserved protein [Function unknown]; Region: COG1432
65093009114	putative metal binding site [ion binding]; other site
65093009115	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
65093009116	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
65093009117	putative active site [active]
65093009118	catalytic triad [active]
65093009119	putative dimer interface [polypeptide binding]; other site
65093009120	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
65093009121	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
65093009122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093009123	putative substrate translocation pore; other site
65093009124	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093009125	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093009126	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
65093009127	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093009128	dimerization interface [polypeptide binding]; other site
65093009129	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036
65093009130	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
65093009131	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
65093009132	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
65093009133	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
65093009134	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
65093009135	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
65093009136	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
65093009137	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
65093009138	MoaE interaction surface [polypeptide binding]; other site
65093009139	MoeB interaction surface [polypeptide binding]; other site
65093009140	thiocarboxylated glycine; other site
65093009141	threonine synthase; Validated; Region: PRK07591
65093009142	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
65093009143	homodimer interface [polypeptide binding]; other site
65093009144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093009145	catalytic residue [active]
65093009146	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
65093009147	heterotetramer interface [polypeptide binding]; other site
65093009148	active site pocket [active]
65093009149	cleavage site
65093009150	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
65093009151	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
65093009152	GatB domain; Region: GatB_Yqey; smart00845
65093009153	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
65093009154	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093009155	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093009156	metal binding site [ion binding]; metal-binding site
65093009157	active site
65093009158	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
65093009159	core dimer interface [polypeptide binding]; other site
65093009160	peripheral dimer interface [polypeptide binding]; other site
65093009161	L10 interface [polypeptide binding]; other site
65093009162	L11 interface [polypeptide binding]; other site
65093009163	putative EF-Tu interaction site [polypeptide binding]; other site
65093009164	putative EF-G interaction site [polypeptide binding]; other site
65093009165	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
65093009166	23S rRNA interface [nucleotide binding]; other site
65093009167	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
65093009168	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
65093009169	mRNA/rRNA interface [nucleotide binding]; other site
65093009170	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
65093009171	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
65093009172	23S rRNA interface [nucleotide binding]; other site
65093009173	L7/L12 interface [polypeptide binding]; other site
65093009174	putative thiostrepton binding site; other site
65093009175	L25 interface [polypeptide binding]; other site
65093009176	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
65093009177	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
65093009178	putative homodimer interface [polypeptide binding]; other site
65093009179	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
65093009180	heterodimer interface [polypeptide binding]; other site
65093009181	homodimer interface [polypeptide binding]; other site
65093009182	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
65093009183	ribosomal protein L19; Region: rpl19; CHL00084
65093009184	PBP superfamily domain; Region: PBP_like_2; cl17296
65093009185	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
65093009186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093009187	dimer interface [polypeptide binding]; other site
65093009188	conserved gate region; other site
65093009189	putative PBP binding loops; other site
65093009190	ABC-ATPase subunit interface; other site
65093009191	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
65093009192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093009193	dimer interface [polypeptide binding]; other site
65093009194	conserved gate region; other site
65093009195	putative PBP binding loops; other site
65093009196	ABC-ATPase subunit interface; other site
65093009197	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
65093009198	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65093009199	Walker A/P-loop; other site
65093009200	ATP binding site [chemical binding]; other site
65093009201	Q-loop/lid; other site
65093009202	ABC transporter signature motif; other site
65093009203	Walker B; other site
65093009204	D-loop; other site
65093009205	H-loop/switch region; other site
65093009206	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
65093009207	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
65093009208	HflX GTPase family; Region: HflX; cd01878
65093009209	G1 box; other site
65093009210	GTP/Mg2+ binding site [chemical binding]; other site
65093009211	Switch I region; other site
65093009212	G2 box; other site
65093009213	G3 box; other site
65093009214	Switch II region; other site
65093009215	G4 box; other site
65093009216	G5 box; other site
65093009217	quinolinate synthetase; Provisional; Region: PRK09375
65093009218	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093009219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093009220	S-adenosylmethionine binding site [chemical binding]; other site
65093009221	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009222	putative active site [active]
65093009223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093009224	S-adenosylmethionine binding site [chemical binding]; other site
65093009225	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
65093009226	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
65093009227	active site residue [active]
65093009228	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
65093009229	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65093009230	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
65093009231	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
65093009232	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
65093009233	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093009234	putative binding surface; other site
65093009235	active site
65093009236	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
65093009237	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
65093009238	ligand binding site [chemical binding]; other site
65093009239	homodimer interface [polypeptide binding]; other site
65093009240	NAD(P) binding site [chemical binding]; other site
65093009241	trimer interface B [polypeptide binding]; other site
65093009242	trimer interface A [polypeptide binding]; other site
65093009243	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
65093009244	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
65093009245	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
65093009246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009247	TPR repeat; Region: TPR_11; pfam13414
65093009248	binding surface
65093009249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009250	TPR motif; other site
65093009251	TPR repeat; Region: TPR_11; pfam13414
65093009252	binding surface
65093009253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009254	binding surface
65093009255	TPR motif; other site
65093009256	TPR repeat; Region: TPR_11; pfam13414
65093009257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009258	binding surface
65093009259	TPR motif; other site
65093009260	TPR repeat; Region: TPR_11; pfam13414
65093009261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009262	binding surface
65093009263	TPR motif; other site
65093009264	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65093009265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009266	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093009267	TPR motif; other site
65093009268	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093009269	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65093009270	Probable Catalytic site; other site
65093009271	metal-binding site
65093009272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093009273	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65093009274	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093009275	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65093009276	Probable Catalytic site; other site
65093009277	metal-binding site
65093009278	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
65093009279	Protein of unknown function (DUF563); Region: DUF563; pfam04577
65093009280	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
65093009281	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
65093009282	substrate binding site; other site
65093009283	metal-binding site
65093009284	Oligomer interface; other site
65093009285	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65093009286	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
65093009287	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
65093009288	NADP binding site [chemical binding]; other site
65093009289	active site
65093009290	putative substrate binding site [chemical binding]; other site
65093009291	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
65093009292	TPR repeat; Region: TPR_11; pfam13414
65093009293	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009294	binding surface
65093009295	TPR motif; other site
65093009296	TPR repeat; Region: TPR_11; pfam13414
65093009297	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093009298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009299	binding surface
65093009300	TPR motif; other site
65093009301	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093009302	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093009303	active site
65093009304	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093009305	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093009306	active site
65093009307	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65093009308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009309	binding surface
65093009310	TPR motif; other site
65093009311	TPR repeat; Region: TPR_11; pfam13414
65093009312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009313	binding surface
65093009314	TPR motif; other site
65093009315	TPR repeat; Region: TPR_11; pfam13414
65093009316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009317	binding surface
65093009318	TPR motif; other site
65093009319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009320	binding surface
65093009321	TPR motif; other site
65093009322	TPR repeat; Region: TPR_11; pfam13414
65093009323	Protein of unknown function (DUF563); Region: DUF563; pfam04577
65093009324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009325	binding surface
65093009326	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093009327	TPR motif; other site
65093009328	TPR repeat; Region: TPR_11; pfam13414
65093009329	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093009330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009331	binding surface
65093009332	TPR motif; other site
65093009333	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009334	binding surface
65093009335	TPR motif; other site
65093009336	TPR repeat; Region: TPR_11; pfam13414
65093009337	TPR repeat; Region: TPR_11; pfam13414
65093009338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009339	binding surface
65093009340	TPR motif; other site
65093009341	TPR repeat; Region: TPR_11; pfam13414
65093009342	TPR repeat; Region: TPR_11; pfam13414
65093009343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009344	binding surface
65093009345	TPR motif; other site
65093009346	TPR repeat; Region: TPR_11; pfam13414
65093009347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009348	binding surface
65093009349	TPR motif; other site
65093009350	TPR repeat; Region: TPR_11; pfam13414
65093009351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009352	TPR motif; other site
65093009353	binding surface
65093009354	TPR repeat; Region: TPR_11; pfam13414
65093009355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009356	binding surface
65093009357	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093009358	TPR motif; other site
65093009359	TPR repeat; Region: TPR_11; pfam13414
65093009360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009361	binding surface
65093009362	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093009363	TPR motif; other site
65093009364	TPR repeat; Region: TPR_11; pfam13414
65093009365	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65093009366	DNA binding residues [nucleotide binding]
65093009367	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65093009368	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
65093009369	catalytic residues [active]
65093009370	catalytic nucleophile [active]
65093009371	Probable transposase; Region: OrfB_IS605; pfam01385
65093009372	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093009373	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093009374	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
65093009375	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
65093009376	Amino acid permease; Region: AA_permease; pfam00324
65093009377	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093009378	Probable transposase; Region: OrfB_IS605; pfam01385
65093009379	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65093009380	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
65093009381	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65093009382	putative active site [active]
65093009383	putative NTP binding site [chemical binding]; other site
65093009384	putative nucleic acid binding site [nucleotide binding]; other site
65093009385	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65093009386	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65093009387	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65093009388	active site
65093009389	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
65093009390	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
65093009391	substrate binding site [chemical binding]; other site
65093009392	catalytic Zn binding site [ion binding]; other site
65093009393	NAD binding site [chemical binding]; other site
65093009394	structural Zn binding site [ion binding]; other site
65093009395	dimer interface [polypeptide binding]; other site
65093009396	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
65093009397	S-formylglutathione hydrolase; Region: PLN02442
65093009398	YrhK-like protein; Region: YrhK; pfam14145
65093009399	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
65093009400	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
65093009401	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
65093009402	hydrolase, alpha/beta fold family protein; Region: PLN02824
65093009403	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
65093009404	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65093009405	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
65093009406	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093009407	RNA binding surface [nucleotide binding]; other site
65093009408	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
65093009409	active site
65093009410	Helix-turn-helix domain; Region: HTH_25; pfam13413
65093009411	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
65093009412	biotin synthase; Validated; Region: PRK06256
65093009413	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093009414	FeS/SAM binding site; other site
65093009415	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
65093009416	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
65093009417	homotrimer interaction site [polypeptide binding]; other site
65093009418	active site
65093009419	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
65093009420	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
65093009421	tandem repeat interface [polypeptide binding]; other site
65093009422	oligomer interface [polypeptide binding]; other site
65093009423	active site residues [active]
65093009424	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65093009425	EamA-like transporter family; Region: EamA; pfam00892
65093009426	EamA-like transporter family; Region: EamA; pfam00892
65093009427	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
65093009428	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65093009429	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
65093009430	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
65093009431	Substrate binding site; other site
65093009432	Mg++ binding site; other site
65093009433	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
65093009434	active site
65093009435	substrate binding site [chemical binding]; other site
65093009436	CoA binding site [chemical binding]; other site
65093009437	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
65093009438	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
65093009439	putative active site [active]
65093009440	catalytic triad [active]
65093009441	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
65093009442	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65093009443	metal binding site 2 [ion binding]; metal-binding site
65093009444	putative DNA binding helix; other site
65093009445	metal binding site 1 [ion binding]; metal-binding site
65093009446	dimer interface [polypeptide binding]; other site
65093009447	structural Zn2+ binding site [ion binding]; other site
65093009448	Putative phosphatase (DUF442); Region: DUF442; cl17385
65093009449	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
65093009450	Response regulator receiver domain; Region: Response_reg; pfam00072
65093009451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093009452	active site
65093009453	phosphorylation site [posttranslational modification]
65093009454	intermolecular recognition site; other site
65093009455	dimerization interface [polypeptide binding]; other site
65093009456	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093009457	NMT1/THI5 like; Region: NMT1; pfam09084
65093009458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
65093009459	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65093009460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65093009461	dimer interface [polypeptide binding]; other site
65093009462	conserved gate region; other site
65093009463	putative PBP binding loops; other site
65093009464	ABC-ATPase subunit interface; other site
65093009465	Isochorismatase family; Region: Isochorismatase; pfam00857
65093009466	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
65093009467	catalytic triad [active]
65093009468	conserved cis-peptide bond; other site
65093009469	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
65093009470	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65093009471	Walker A/P-loop; other site
65093009472	ATP binding site [chemical binding]; other site
65093009473	Q-loop/lid; other site
65093009474	ABC transporter signature motif; other site
65093009475	Walker B; other site
65093009476	D-loop; other site
65093009477	H-loop/switch region; other site
65093009478	Response regulator receiver domain; Region: Response_reg; pfam00072
65093009479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093009480	active site
65093009481	phosphorylation site [posttranslational modification]
65093009482	intermolecular recognition site; other site
65093009483	dimerization interface [polypeptide binding]; other site
65093009484	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65093009485	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65093009486	dimerization interface [polypeptide binding]; other site
65093009487	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65093009488	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65093009489	dimer interface [polypeptide binding]; other site
65093009490	putative CheW interface [polypeptide binding]; other site
65093009491	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65093009492	putative binding surface; other site
65093009493	active site
65093009494	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65093009495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093009496	ATP binding site [chemical binding]; other site
65093009497	Mg2+ binding site [ion binding]; other site
65093009498	G-X-G motif; other site
65093009499	CheW-like domain; Region: CheW; pfam01584
65093009500	Response regulator receiver domain; Region: Response_reg; pfam00072
65093009501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093009502	active site
65093009503	phosphorylation site [posttranslational modification]
65093009504	intermolecular recognition site; other site
65093009505	dimerization interface [polypeptide binding]; other site
65093009506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093009507	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093009508	Probable transposase; Region: OrfB_IS605; pfam01385
65093009509	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093009510	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65093009511	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65093009512	DNA binding residues [nucleotide binding]
65093009513	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
65093009514	catalytic nucleophile [active]
65093009515	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
65093009516	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093009517	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65093009518	TPR repeat; Region: TPR_11; pfam13414
65093009519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009520	binding surface
65093009521	TPR motif; other site
65093009522	TPR repeat; Region: TPR_11; pfam13414
65093009523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009524	binding surface
65093009525	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093009526	TPR motif; other site
65093009527	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093009528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093009529	binding surface
65093009530	TPR motif; other site
65093009531	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65093009532	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
65093009533	active site
65093009534	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
65093009535	homotrimer interaction site [polypeptide binding]; other site
65093009536	putative active site [active]
65093009537	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
65093009538	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
65093009539	Walker A/P-loop; other site
65093009540	ATP binding site [chemical binding]; other site
65093009541	Q-loop/lid; other site
65093009542	ABC transporter signature motif; other site
65093009543	Walker B; other site
65093009544	D-loop; other site
65093009545	H-loop/switch region; other site
65093009546	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
65093009547	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65093009548	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65093009549	TM-ABC transporter signature motif; other site
65093009550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093009551	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093009552	Probable transposase; Region: OrfB_IS605; pfam01385
65093009553	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
65093009554	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
65093009555	putative active site [active]
65093009556	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
65093009557	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
65093009558	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
65093009559	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093009560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093009561	homodimer interface [polypeptide binding]; other site
65093009562	catalytic residue [active]
65093009563	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
65093009564	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
65093009565	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
65093009566	N-acetyl-D-glucosamine binding site [chemical binding]; other site
65093009567	catalytic residue [active]
65093009568	GAF domain; Region: GAF; cl17456
65093009569	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093009570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093009571	ATP binding site [chemical binding]; other site
65093009572	Mg2+ binding site [ion binding]; other site
65093009573	G-X-G motif; other site
65093009574	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
65093009575	Domain of unknown function DUF29; Region: DUF29; pfam01724
65093009576	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
65093009577	CAAX protease self-immunity; Region: Abi; pfam02517
65093009578	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
65093009579	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
65093009580	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
65093009581	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65093009582	active site residue [active]
65093009583	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
65093009584	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
65093009585	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
65093009586	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
65093009587	dihydrodipicolinate synthase; Region: dapA; TIGR00674
65093009588	dimer interface [polypeptide binding]; other site
65093009589	active site
65093009590	catalytic residue [active]
65093009591	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
65093009592	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
65093009593	trigger factor; Provisional; Region: tig; PRK01490
65093009594	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
65093009595	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65093009596	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
65093009597	Clp protease; Region: CLP_protease; pfam00574
65093009598	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65093009599	oligomer interface [polypeptide binding]; other site
65093009600	active site residues [active]
65093009601	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
65093009602	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
65093009603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093009604	Walker A motif; other site
65093009605	ATP binding site [chemical binding]; other site
65093009606	Walker B motif; other site
65093009607	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
65093009608	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
65093009609	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
65093009610	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65093009611	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65093009612	active site
65093009613	metal binding site [ion binding]; metal-binding site
65093009614	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
65093009615	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
65093009616	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
65093009617	ThiS interaction site; other site
65093009618	putative active site [active]
65093009619	tetramer interface [polypeptide binding]; other site
65093009620	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65093009621	deoxycytidine triphosphate deaminase; Reviewed; Region: dcd; PRK00416
65093009622	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093009623	protein-splicing catalytic site; other site
65093009624	thioester formation/cholesterol transfer; other site
65093009625	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
65093009626	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
65093009627	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
65093009628	trimer interface [polypeptide binding]; other site
65093009629	active site
65093009630	Thymidylate synthase complementing protein; Region: Thy1; cl03630
65093009631	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65093009632	protein-splicing catalytic site; other site
65093009633	thioester formation/cholesterol transfer; other site
65093009634	Thymidylate synthase complementing protein; Region: Thy1; cl03630
65093009635	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
65093009636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093009637	FeS/SAM binding site; other site
65093009638	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
65093009639	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
65093009640	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
65093009641	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093009642	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
65093009643	PAS domain S-box; Region: sensory_box; TIGR00229
65093009644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093009645	putative active site [active]
65093009646	heme pocket [chemical binding]; other site
65093009647	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
65093009648	Glutaminase; Region: Glutaminase; cl00907
65093009649	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
65093009650	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093009651	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65093009652	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
65093009653	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
65093009654	metal binding site [ion binding]; metal-binding site
65093009655	dimer interface [polypeptide binding]; other site
65093009656	AAA domain; Region: AAA_26; pfam13500
65093009657	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
65093009658	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
65093009659	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
65093009660	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093009661	active site
65093009662	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65093009663	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
65093009664	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
65093009665	NADP-binding site; other site
65093009666	homotetramer interface [polypeptide binding]; other site
65093009667	substrate binding site [chemical binding]; other site
65093009668	homodimer interface [polypeptide binding]; other site
65093009669	active site
65093009670	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
65093009671	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
65093009672	NADP binding site [chemical binding]; other site
65093009673	active site
65093009674	putative substrate binding site [chemical binding]; other site
65093009675	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65093009676	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65093009677	AMIN domain; Region: AMIN; pfam11741
65093009678	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
65093009679	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
65093009680	active site
65093009681	metal binding site [ion binding]; metal-binding site
65093009682	glutamate racemase; Provisional; Region: PRK00865
65093009683	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093009684	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65093009685	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65093009686	ligand binding site [chemical binding]; other site
65093009687	flexible hinge region; other site
65093009688	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
65093009689	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
65093009690	putative di-iron ligands [ion binding]; other site
65093009691	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
65093009692	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
65093009693	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
65093009694	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
65093009695	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
65093009696	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
65093009697	ResB-like family; Region: ResB; pfam05140
65093009698	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
65093009699	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
65093009700	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65093009701	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65093009702	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093009703	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
65093009704	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
65093009705	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
65093009706	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
65093009707	putative metal binding site [ion binding]; other site
65093009708	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
65093009709	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65093009710	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65093009711	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65093009712	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
65093009713	putative active site [active]
65093009714	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093009715	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
65093009716	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65093009717	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
65093009718	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
65093009719	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093009720	ATP binding site [chemical binding]; other site
65093009721	putative Mg++ binding site [ion binding]; other site
65093009722	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
65093009723	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
65093009724	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
65093009725	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
65093009726	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
65093009727	dimer interface [polypeptide binding]; other site
65093009728	active site
65093009729	CoA binding pocket [chemical binding]; other site
65093009730	putative phosphate acyltransferase; Provisional; Region: PRK05331
65093009731	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
65093009732	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
65093009733	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
65093009734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65093009735	Walker A/P-loop; other site
65093009736	ATP binding site [chemical binding]; other site
65093009737	Q-loop/lid; other site
65093009738	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65093009739	ABC transporter; Region: ABC_tran_2; pfam12848
65093009740	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65093009741	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65093009742	XisI protein; Region: XisI; pfam08869
65093009743	XisH protein; Region: XisH; pfam08814
65093009744	Protein of unknown function DUF104; Region: DUF104; cl11530
65093009745	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
65093009746	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009747	putative active site [active]
65093009748	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
65093009749	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
65093009750	substrate binding site [chemical binding]; other site
65093009751	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
65093009752	substrate binding site [chemical binding]; other site
65093009753	ligand binding site [chemical binding]; other site
65093009754	Cadherin repeat-like domain; Region: CA_like; cl15786
65093009755	Ca2+ binding site [ion binding]; other site
65093009756	VCBS repeat; Region: VCBS_repeat; TIGR01965
65093009757	VCBS repeat; Region: VCBS_repeat; TIGR01965
65093009758	VCBS repeat; Region: VCBS_repeat; TIGR01965
65093009759	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65093009760	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65093009761	Surface antigen; Region: Bac_surface_Ag; pfam01103
65093009762	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65093009763	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65093009764	CHAT domain; Region: CHAT; cl17868
65093009765	Uncharacterized conserved protein [Function unknown]; Region: COG0398
65093009766	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
65093009767	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
65093009768	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093009769	FeS/SAM binding site; other site
65093009770	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
65093009771	N2,N2-dimethylguanosine tRNA methyltransferase; Region: TRM; pfam02005
65093009772	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009773	putative active site [active]
65093009774	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
65093009775	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
65093009776	arginine-tRNA ligase; Region: PLN02286
65093009777	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
65093009778	active site
65093009779	HIGH motif; other site
65093009780	KMSK motif region; other site
65093009781	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
65093009782	tRNA binding surface [nucleotide binding]; other site
65093009783	anticodon binding site; other site
65093009784	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
65093009785	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
65093009786	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
65093009787	generic binding surface I; other site
65093009788	generic binding surface II; other site
65093009789	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
65093009790	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65093009791	Uncharacterized conserved protein [Function unknown]; Region: COG3937
65093009792	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65093009793	Ycf39; Provisional; Region: ycf39; CHL00194
65093009794	NAD(P) binding site [chemical binding]; other site
65093009795	putative active site [active]
65093009796	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
65093009797	putative catalytic site [active]
65093009798	putative phosphate binding site [ion binding]; other site
65093009799	active site
65093009800	metal binding site A [ion binding]; metal-binding site
65093009801	DNA binding site [nucleotide binding]
65093009802	putative AP binding site [nucleotide binding]; other site
65093009803	putative metal binding site B [ion binding]; other site
65093009804	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093009805	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65093009806	catalytic site [active]
65093009807	Predicted permeases [General function prediction only]; Region: COG0679
65093009808	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
65093009809	IHF dimer interface [polypeptide binding]; other site
65093009810	IHF - DNA interface [nucleotide binding]; other site
65093009811	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
65093009812	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65093009813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093009814	homodimer interface [polypeptide binding]; other site
65093009815	catalytic residue [active]
65093009816	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
65093009817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093009818	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65093009819	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093009820	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093009821	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093009822	active site
65093009823	ATP binding site [chemical binding]; other site
65093009824	substrate binding site [chemical binding]; other site
65093009825	activation loop (A-loop); other site
65093009826	S-layer homology domain; Region: SLH; pfam00395
65093009827	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
65093009828	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
65093009829	Caspase domain; Region: Peptidase_C14; pfam00656
65093009830	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65093009831	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093009832	Circadian oscillating protein COP23; Region: COP23; pfam14218
65093009833	CHAT domain; Region: CHAT; cl17868
65093009834	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093009835	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093009836	phosphopeptide binding site; other site
65093009837	DREPP plasma membrane polypeptide; Region: DREPP; pfam05558
65093009838	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65093009839	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65093009840	structural tetrad; other site
65093009841	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
65093009842	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65093009843	Prominin; Region: Prominin; pfam05478
65093009844	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093009845	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093009846	phosphopeptide binding site; other site
65093009847	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
65093009848	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65093009849	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65093009850	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
65093009851	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
65093009852	putative active site [active]
65093009853	homotetrameric interface [polypeptide binding]; other site
65093009854	metal binding site [ion binding]; metal-binding site
65093009855	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
65093009856	active site
65093009857	ribulose/triose binding site [chemical binding]; other site
65093009858	phosphate binding site [ion binding]; other site
65093009859	substrate (anthranilate) binding pocket [chemical binding]; other site
65093009860	product (indole) binding pocket [chemical binding]; other site
65093009861	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
65093009862	homodimer interface [polypeptide binding]; other site
65093009863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093009864	catalytic residue [active]
65093009865	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
65093009866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
65093009867	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
65093009868	Uncharacterized conserved protein [Function unknown]; Region: COG2006
65093009869	Domain of unknown function (DUF362); Region: DUF362; pfam04015
65093009870	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
65093009871	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
65093009872	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
65093009873	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093009874	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
65093009875	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093009876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
65093009877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65093009878	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
65093009879	putative dimerization interface [polypeptide binding]; other site
65093009880	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
65093009881	Uncharacterized conserved protein [Function unknown]; Region: COG1434
65093009882	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65093009883	putative active site [active]
65093009884	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
65093009885	active site
65093009886	dimer interface [polypeptide binding]; other site
65093009887	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
65093009888	active site
65093009889	dimer interface [polypeptide binding]; other site
65093009890	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65093009891	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
65093009892	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65093009893	PYR/PP interface [polypeptide binding]; other site
65093009894	dimer interface [polypeptide binding]; other site
65093009895	TPP binding site [chemical binding]; other site
65093009896	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65093009897	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
65093009898	TPP-binding site [chemical binding]; other site
65093009899	dimer interface [polypeptide binding]; other site
65093009900	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65093009901	Thioesterase domain; Region: Thioesterase; pfam00975
65093009902	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
65093009903	substrate binding site [chemical binding]; other site
65093009904	NACHT domain; Region: NACHT; pfam05729
65093009905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009906	putative active site [active]
65093009907	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093009908	G1 box; other site
65093009909	GTP/Mg2+ binding site [chemical binding]; other site
65093009910	G2 box; other site
65093009911	Switch I region; other site
65093009912	G3 box; other site
65093009913	Switch II region; other site
65093009914	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
65093009915	G1 box; other site
65093009916	GTP/Mg2+ binding site [chemical binding]; other site
65093009917	G2 box; other site
65093009918	Switch I region; other site
65093009919	G3 box; other site
65093009920	Switch II region; other site
65093009921	G4 box; other site
65093009922	G5 box; other site
65093009923	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009924	putative active site [active]
65093009925	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093009926	putative active site [active]
65093009927	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093009928	YcfA-like protein; Region: YcfA; cl00752
65093009929	recombination regulator RecX; Reviewed; Region: recX; PRK00117
65093009930	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
65093009931	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
65093009932	active site
65093009933	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
65093009934	protein binding site [polypeptide binding]; other site
65093009935	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
65093009936	putative substrate binding region [chemical binding]; other site
65093009937	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
65093009938	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65093009939	minor groove reading motif; other site
65093009940	helix-hairpin-helix signature motif; other site
65093009941	substrate binding pocket [chemical binding]; other site
65093009942	active site
65093009943	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
65093009944	ribosomal protein S14; Region: rps14; CHL00074
65093009945	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
65093009946	Predicted methyltransferases [General function prediction only]; Region: COG0313
65093009947	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
65093009948	putative SAM binding site [chemical binding]; other site
65093009949	putative homodimer interface [polypeptide binding]; other site
65093009950	phosphoglycolate phosphatase; Provisional; Region: PRK01158
65093009951	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093009952	active site
65093009953	motif I; other site
65093009954	motif II; other site
65093009955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093009956	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093009957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093009958	S-adenosylmethionine binding site [chemical binding]; other site
65093009959	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65093009960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093009961	S-adenosylmethionine binding site [chemical binding]; other site
65093009962	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
65093009963	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
65093009964	dimerization interface [polypeptide binding]; other site
65093009965	active site
65093009966	metal binding site [ion binding]; metal-binding site
65093009967	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
65093009968	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
65093009969	RibD C-terminal domain; Region: RibD_C; cl17279
65093009970	Late competence development protein ComFB; Region: ComFB; pfam10719
65093009971	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65093009972	Peptidase family M23; Region: Peptidase_M23; pfam01551
65093009973	Sm and related proteins; Region: Sm_like; cl00259
65093009974	heptamer interface [polypeptide binding]; other site
65093009975	Sm1 motif; other site
65093009976	hexamer interface [polypeptide binding]; other site
65093009977	RNA binding site [nucleotide binding]; other site
65093009978	Sm2 motif; other site
65093009979	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
65093009980	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
65093009981	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
65093009982	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
65093009983	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
65093009984	active site
65093009985	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
65093009986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093009987	S-adenosylmethionine binding site [chemical binding]; other site
65093009988	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
65093009989	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
65093009990	diiron binding motif [ion binding]; other site
65093009991	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
65093009992	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093009993	homoserine kinase; Provisional; Region: PRK01212
65093009994	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
65093009995	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093009996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093009997	active site
65093009998	phosphorylation site [posttranslational modification]
65093009999	intermolecular recognition site; other site
65093010000	dimerization interface [polypeptide binding]; other site
65093010001	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
65093010002	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
65093010003	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093010004	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
65093010005	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65093010006	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093010007	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65093010008	Hexamer interface [polypeptide binding]; other site
65093010009	Hexagonal pore residue; other site
65093010010	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65093010011	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65093010012	Hexamer interface [polypeptide binding]; other site
65093010013	Hexagonal pore residue; other site
65093010014	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
65093010015	Hexamer/Pentamer interface [polypeptide binding]; other site
65093010016	central pore; other site
65093010017	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
65093010018	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
65093010019	trimer interface [polypeptide binding]; other site
65093010020	active site
65093010021	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65093010022	putative multimerization interface [polypeptide binding]; other site
65093010023	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65093010024	putative multimerization interface [polypeptide binding]; other site
65093010025	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65093010026	putative multimerization interface [polypeptide binding]; other site
65093010027	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65093010028	putative multimerization interface [polypeptide binding]; other site
65093010029	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
65093010030	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
65093010031	homodimer interface [polypeptide binding]; other site
65093010032	active site
65093010033	heterodimer interface [polypeptide binding]; other site
65093010034	catalytic residue [active]
65093010035	metal binding site [ion binding]; metal-binding site
65093010036	RbcX protein; Region: RcbX; pfam02341
65093010037	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
65093010038	multimerization interface [polypeptide binding]; other site
65093010039	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
65093010040	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65093010041	RNA binding surface [nucleotide binding]; other site
65093010042	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
65093010043	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65093010044	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65093010045	phosphopeptide binding site; other site
65093010046	NAD synthetase; Provisional; Region: PRK13981
65093010047	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
65093010048	multimer interface [polypeptide binding]; other site
65093010049	active site
65093010050	catalytic triad [active]
65093010051	protein interface 1 [polypeptide binding]; other site
65093010052	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
65093010053	homodimer interface [polypeptide binding]; other site
65093010054	NAD binding pocket [chemical binding]; other site
65093010055	ATP binding pocket [chemical binding]; other site
65093010056	Mg binding site [ion binding]; other site
65093010057	active-site loop [active]
65093010058	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65093010059	nudix motif; other site
65093010060	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
65093010061	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
65093010062	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
65093010063	active site
65093010064	(T/H)XGH motif; other site
65093010065	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
65093010066	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
65093010067	active site
65093010068	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
65093010069	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65093010070	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093010071	FeS/SAM binding site; other site
65093010072	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
65093010073	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65093010074	Zn2+ binding site [ion binding]; other site
65093010075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010076	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093010077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010079	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093010080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010081	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093010082	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010083	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65093010084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010085	Probable transposase; Region: OrfB_IS605; pfam01385
65093010086	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
65093010087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093010088	FeS/SAM binding site; other site
65093010089	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65093010090	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65093010091	protein binding site [polypeptide binding]; other site
65093010092	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
65093010093	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65093010094	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65093010095	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
65093010096	C-terminal domain interface [polypeptide binding]; other site
65093010097	GSH binding site (G-site) [chemical binding]; other site
65093010098	dimer interface [polypeptide binding]; other site
65093010099	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
65093010100	N-terminal domain interface [polypeptide binding]; other site
65093010101	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
65093010102	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
65093010103	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
65093010104	dimer interface [polypeptide binding]; other site
65093010105	ssDNA binding site [nucleotide binding]; other site
65093010106	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65093010107	GTP-binding protein Der; Reviewed; Region: PRK00093
65093010108	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
65093010109	G1 box; other site
65093010110	GTP/Mg2+ binding site [chemical binding]; other site
65093010111	Switch I region; other site
65093010112	G2 box; other site
65093010113	Switch II region; other site
65093010114	G3 box; other site
65093010115	G4 box; other site
65093010116	G5 box; other site
65093010117	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
65093010118	G1 box; other site
65093010119	GTP/Mg2+ binding site [chemical binding]; other site
65093010120	Switch I region; other site
65093010121	G2 box; other site
65093010122	G3 box; other site
65093010123	Switch II region; other site
65093010124	G4 box; other site
65093010125	G5 box; other site
65093010126	Cobalt transport protein; Region: CbiQ; pfam02361
65093010127	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
65093010128	DHH family; Region: DHH; pfam01368
65093010129	DHHA1 domain; Region: DHHA1; pfam02272
65093010130	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
65093010131	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
65093010132	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
65093010133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093010134	putative substrate translocation pore; other site
65093010135	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
65093010136	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
65093010137	active site
65093010138	dimer interface [polypeptide binding]; other site
65093010139	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
65093010140	dimer interface [polypeptide binding]; other site
65093010141	active site
65093010142	FtsH Extracellular; Region: FtsH_ext; pfam06480
65093010143	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
65093010144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65093010145	Walker A motif; other site
65093010146	ATP binding site [chemical binding]; other site
65093010147	Walker B motif; other site
65093010148	arginine finger; other site
65093010149	Peptidase family M41; Region: Peptidase_M41; pfam01434
65093010150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010151	Probable transposase; Region: OrfB_IS605; pfam01385
65093010152	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65093010153	TrkA-N domain; Region: TrkA_N; pfam02254
65093010154	TrkA-C domain; Region: TrkA_C; pfam02080
65093010155	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
65093010156	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
65093010157	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
65093010158	homooctamer interface [polypeptide binding]; other site
65093010159	active site
65093010160	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
65093010161	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
65093010162	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
65093010163	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65093010164	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
65093010165	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65093010166	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65093010167	anti sigma factor interaction site; other site
65093010168	regulatory phosphorylation site [posttranslational modification]; other site
65093010169	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
65093010170	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
65093010171	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
65093010172	catalytic site [active]
65093010173	subunit interface [polypeptide binding]; other site
65093010174	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010175	putative active site [active]
65093010176	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010177	putative active site [active]
65093010178	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
65093010179	homotrimer interaction site [polypeptide binding]; other site
65093010180	zinc binding site [ion binding]; other site
65093010181	CDP-binding sites; other site
65093010182	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65093010183	ABC1 family; Region: ABC1; pfam03109
65093010184	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65093010185	active site
65093010186	ATP binding site [chemical binding]; other site
65093010187	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093010188	G4 box; other site
65093010189	flavodoxin FldA; Validated; Region: PRK09267
65093010190	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
65093010191	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
65093010192	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
65093010193	H+ Antiporter protein; Region: 2A0121; TIGR00900
65093010194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093010195	putative substrate translocation pore; other site
65093010196	AMIN domain; Region: AMIN; pfam11741
65093010197	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
65093010198	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
65093010199	N-terminal plug; other site
65093010200	ligand-binding site [chemical binding]; other site
65093010201	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
65093010202	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
65093010203	siderophore binding site; other site
65093010204	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
65093010205	putative dimer interface [polypeptide binding]; other site
65093010206	putative [2Fe-2S] cluster binding site [ion binding]; other site
65093010207	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
65093010208	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
65093010209	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
65093010210	putative dimer interface [polypeptide binding]; other site
65093010211	N-terminal domain interface [polypeptide binding]; other site
65093010212	putative substrate binding pocket (H-site) [chemical binding]; other site
65093010213	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
65093010214	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
65093010215	Substrate binding site; other site
65093010216	Cupin domain; Region: Cupin_2; cl17218
65093010217	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010218	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65093010219	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010220	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65093010221	Probable transposase; Region: OrfB_IS605; pfam01385
65093010222	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093010223	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65093010224	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
65093010225	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
65093010226	dimer interface [polypeptide binding]; other site
65093010227	tetramer interface [polypeptide binding]; other site
65093010228	PYR/PP interface [polypeptide binding]; other site
65093010229	TPP binding site [chemical binding]; other site
65093010230	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
65093010231	TPP-binding site; other site
65093010232	CAAX protease self-immunity; Region: Abi; pfam02517
65093010233	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
65093010234	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
65093010235	metal binding site [ion binding]; metal-binding site
65093010236	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
65093010237	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
65093010238	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
65093010239	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65093010240	ABC-ATPase subunit  interface; other site
65093010241	dimer interface [polypeptide binding]; other site
65093010242	putative PBP binding regions; other site
65093010243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010244	Probable transposase; Region: OrfB_IS605; pfam01385
65093010245	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093010246	acetyl-CoA synthetase; Provisional; Region: PRK00174
65093010247	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
65093010248	active site
65093010249	CoA binding site [chemical binding]; other site
65093010250	acyl-activating enzyme (AAE) consensus motif; other site
65093010251	AMP binding site [chemical binding]; other site
65093010252	acetate binding site [chemical binding]; other site
65093010253	Dynamin family; Region: Dynamin_N; pfam00350
65093010254	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65093010255	G1 box; other site
65093010256	GTP/Mg2+ binding site [chemical binding]; other site
65093010257	Switch I region; other site
65093010258	G2 box; other site
65093010259	Switch II region; other site
65093010260	G3 box; other site
65093010261	G4 box; other site
65093010262	G5 box; other site
65093010263	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65093010264	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010265	putative active site [active]
65093010266	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
65093010267	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65093010268	ATP binding site [chemical binding]; other site
65093010269	putative Mg++ binding site [ion binding]; other site
65093010270	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093010271	nucleotide binding region [chemical binding]; other site
65093010272	ATP-binding site [chemical binding]; other site
65093010273	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
65093010274	HRDC domain; Region: HRDC; pfam00570
65093010275	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
65093010276	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
65093010277	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
65093010278	putative active site [active]
65093010279	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
65093010280	putative active site [active]
65093010281	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
65093010282	MltA specific insert domain; Region: MltA; pfam03562
65093010283	3D domain; Region: 3D; pfam06725
65093010284	FOG: CBS domain [General function prediction only]; Region: COG0517
65093010285	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
65093010286	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
65093010287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093010288	putative substrate translocation pore; other site
65093010289	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
65093010290	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
65093010291	Ligand Binding Site [chemical binding]; other site
65093010292	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
65093010293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093010294	motif II; other site
65093010295	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093010296	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
65093010297	cofactor binding site; other site
65093010298	DNA binding site [nucleotide binding]
65093010299	substrate interaction site [chemical binding]; other site
65093010300	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65093010301	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65093010302	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093010303	DNA binding residues [nucleotide binding]
65093010304	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093010305	dimerization interface [polypeptide binding]; other site
65093010306	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
65093010307	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
65093010308	PRC-barrel domain; Region: PRC; pfam05239
65093010309	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65093010310	Cytochrome P450; Region: p450; cl12078
65093010311	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
65093010312	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
65093010313	tetramer interface [polypeptide binding]; other site
65093010314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093010315	catalytic residue [active]
65093010316	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
65093010317	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
65093010318	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
65093010319	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
65093010320	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65093010321	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65093010322	active site
65093010323	ATP binding site [chemical binding]; other site
65093010324	substrate binding site [chemical binding]; other site
65093010325	activation loop (A-loop); other site
65093010326	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
65093010327	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
65093010328	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65093010329	putative active site [active]
65093010330	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65093010331	DNA methylase; Region: N6_N4_Mtase; cl17433
65093010332	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
65093010333	addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607
65093010334	non-specific DNA binding site [nucleotide binding]; other site
65093010335	salt bridge; other site
65093010336	sequence-specific DNA binding site [nucleotide binding]; other site
65093010337	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
65093010338	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
65093010339	AAA domain; Region: AAA_23; pfam13476
65093010340	Walker A/P-loop; other site
65093010341	ATP binding site [chemical binding]; other site
65093010342	Q-loop/lid; other site
65093010343	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
65093010344	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
65093010345	ABC transporter signature motif; other site
65093010346	Walker B; other site
65093010347	D-loop; other site
65093010348	H-loop/switch region; other site
65093010349	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093010350	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
65093010351	cofactor binding site; other site
65093010352	DNA binding site [nucleotide binding]
65093010353	substrate interaction site [chemical binding]; other site
65093010354	HindVP restriction endonuclease; Region: RE_HindVP; pfam09519
65093010355	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
65093010356	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
65093010357	putative active site [active]
65093010358	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65093010359	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
65093010360	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
65093010361	Helix-turn-helix domain; Region: HTH_17; pfam12728
65093010362	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093010363	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65093010364	cofactor binding site; other site
65093010365	DNA binding site [nucleotide binding]
65093010366	substrate interaction site [chemical binding]; other site
65093010367	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093010368	NgoBV restriction endonuclease; Region: RE_NgoBV; pfam09564
65093010369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65093010370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65093010371	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
65093010372	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65093010373	HlyD family secretion protein; Region: HlyD_3; pfam13437
65093010374	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093010375	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65093010376	Walker A/P-loop; other site
65093010377	ATP binding site [chemical binding]; other site
65093010378	Q-loop/lid; other site
65093010379	ABC transporter signature motif; other site
65093010380	Walker B; other site
65093010381	D-loop; other site
65093010382	H-loop/switch region; other site
65093010383	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65093010384	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65093010385	Walker A/P-loop; other site
65093010386	ATP binding site [chemical binding]; other site
65093010387	Q-loop/lid; other site
65093010388	ABC transporter signature motif; other site
65093010389	Walker B; other site
65093010390	D-loop; other site
65093010391	H-loop/switch region; other site
65093010392	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65093010393	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65093010394	cofactor binding site; other site
65093010395	DNA binding site [nucleotide binding]
65093010396	substrate interaction site [chemical binding]; other site
65093010397	Bacitracin resistance protein BacA; Region: BacA; pfam02673
65093010398	FOG: CBS domain [General function prediction only]; Region: COG0517
65093010399	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
65093010400	CP12 domain; Region: CP12; pfam02672
65093010401	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
65093010402	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
65093010403	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
65093010404	active site
65093010405	catalytic site [active]
65093010406	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65093010407	dimerization interface [polypeptide binding]; other site
65093010408	putative DNA binding site [nucleotide binding]; other site
65093010409	putative Zn2+ binding site [ion binding]; other site
65093010410	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
65093010411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093010412	FeS/SAM binding site; other site
65093010413	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
65093010414	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65093010415	metal binding site 2 [ion binding]; metal-binding site
65093010416	putative DNA binding helix; other site
65093010417	metal binding site 1 [ion binding]; metal-binding site
65093010418	dimer interface [polypeptide binding]; other site
65093010419	structural Zn2+ binding site [ion binding]; other site
65093010420	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010421	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010422	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010423	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010424	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010425	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010426	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010427	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010428	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
65093010429	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65093010430	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65093010431	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
65093010432	propionate/acetate kinase; Provisional; Region: PRK12379
65093010433	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
65093010434	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093010435	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
65093010436	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093010437	phytoene desaturase; Region: phytoene_desat; TIGR02731
65093010438	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093010439	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
65093010440	active site lid residues [active]
65093010441	substrate binding pocket [chemical binding]; other site
65093010442	catalytic residues [active]
65093010443	substrate-Mg2+ binding site; other site
65093010444	aspartate-rich region 1; other site
65093010445	aspartate-rich region 2; other site
65093010446	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
65093010447	GIY-YIG motif/motif A; other site
65093010448	active site
65093010449	catalytic site [active]
65093010450	metal binding site [ion binding]; metal-binding site
65093010451	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
65093010452	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010453	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010454	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
65093010455	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
65093010456	homotetramer interface [polypeptide binding]; other site
65093010457	ligand binding site [chemical binding]; other site
65093010458	catalytic site [active]
65093010459	NAD binding site [chemical binding]; other site
65093010460	DNA polymerase I; Provisional; Region: PRK05755
65093010461	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
65093010462	active site
65093010463	metal binding site 1 [ion binding]; metal-binding site
65093010464	putative 5' ssDNA interaction site; other site
65093010465	metal binding site 3; metal-binding site
65093010466	metal binding site 2 [ion binding]; metal-binding site
65093010467	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
65093010468	putative DNA binding site [nucleotide binding]; other site
65093010469	putative metal binding site [ion binding]; other site
65093010470	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
65093010471	active site
65093010472	catalytic site [active]
65093010473	substrate binding site [chemical binding]; other site
65093010474	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
65093010475	active site
65093010476	DNA binding site [nucleotide binding]
65093010477	catalytic site [active]
65093010478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010479	Probable transposase; Region: OrfB_IS605; pfam01385
65093010480	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65093010481	DNA binding residues [nucleotide binding]
65093010482	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65093010483	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
65093010484	catalytic residues [active]
65093010485	catalytic nucleophile [active]
65093010486	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
65093010487	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
65093010488	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
65093010489	Family of unknown function (DUF490); Region: DUF490; pfam04357
65093010490	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65093010491	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
65093010492	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65093010493	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65093010494	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65093010495	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65093010496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65093010497	DNA binding residues [nucleotide binding]
65093010498	light-harvesting-like protein 3; Provisional; Region: PLN00014
65093010499	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
65093010500	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
65093010501	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
65093010502	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
65093010503	nitrilase; Region: PLN02798
65093010504	putative active site [active]
65093010505	catalytic triad [active]
65093010506	dimer interface [polypeptide binding]; other site
65093010507	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
65093010508	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
65093010509	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
65093010510	acyl-activating enzyme (AAE) consensus motif; other site
65093010511	putative AMP binding site [chemical binding]; other site
65093010512	putative active site [active]
65093010513	putative CoA binding site [chemical binding]; other site
65093010514	Uncharacterized conserved protein [Function unknown]; Region: COG5607
65093010515	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
65093010516	TPR repeat; Region: TPR_11; pfam13414
65093010517	TPR repeat; Region: TPR_11; pfam13414
65093010518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093010519	binding surface
65093010520	TPR motif; other site
65093010521	TPR repeat; Region: TPR_11; pfam13414
65093010522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093010523	binding surface
65093010524	TPR motif; other site
65093010525	TPR repeat; Region: TPR_11; pfam13414
65093010526	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65093010527	classical (c) SDRs; Region: SDR_c; cd05233
65093010528	NAD(P) binding site [chemical binding]; other site
65093010529	active site
65093010530	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
65093010531	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
65093010532	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
65093010533	dimerization interface [polypeptide binding]; other site
65093010534	active site
65093010535	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010536	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093010538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093010539	active site
65093010540	phosphorylation site [posttranslational modification]
65093010541	intermolecular recognition site; other site
65093010542	dimerization interface [polypeptide binding]; other site
65093010543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093010544	DNA binding residues [nucleotide binding]
65093010545	dimerization interface [polypeptide binding]; other site
65093010546	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093010547	active site
65093010548	tellurium resistance terB-like protein; Region: terB_like; cd07177
65093010549	metal binding site [ion binding]; metal-binding site
65093010550	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
65093010551	PsaX family; Region: PsaX; pfam08078
65093010552	lipoyl synthase; Provisional; Region: PRK12928
65093010553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093010554	FeS/SAM binding site; other site
65093010555	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
65093010556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65093010557	NAD(P) binding site [chemical binding]; other site
65093010558	active site
65093010559	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
65093010560	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
65093010561	active site
65093010562	HIGH motif; other site
65093010563	dimer interface [polypeptide binding]; other site
65093010564	KMSKS motif; other site
65093010565	PemK-like protein; Region: PemK; pfam02452
65093010566	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
65093010567	trimer interface [polypeptide binding]; other site
65093010568	dimer interface [polypeptide binding]; other site
65093010569	putative active site [active]
65093010570	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
65093010571	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65093010572	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65093010573	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65093010574	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
65093010575	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
65093010576	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65093010577	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65093010578	active site
65093010579	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
65093010580	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65093010581	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
65093010582	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
65093010583	Walker A/P-loop; other site
65093010584	ATP binding site [chemical binding]; other site
65093010585	Q-loop/lid; other site
65093010586	ABC transporter signature motif; other site
65093010587	Walker B; other site
65093010588	D-loop; other site
65093010589	H-loop/switch region; other site
65093010590	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
65093010591	putative carbohydrate binding site [chemical binding]; other site
65093010592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093010593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
65093010594	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
65093010595	Probable Catalytic site; other site
65093010596	metal-binding site
65093010597	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65093010598	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65093010599	Probable Catalytic site; other site
65093010600	metal-binding site
65093010601	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
65093010602	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
65093010603	inhibitor-cofactor binding pocket; inhibition site
65093010604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093010605	catalytic residue [active]
65093010606	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65093010607	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
65093010608	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65093010609	putative di-iron ligands [ion binding]; other site
65093010610	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65093010611	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65093010612	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65093010613	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65093010614	putative acyl-acceptor binding pocket; other site
65093010615	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
65093010616	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
65093010617	active site
65093010618	HIGH motif; other site
65093010619	KMSKS motif; other site
65093010620	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
65093010621	tRNA binding surface [nucleotide binding]; other site
65093010622	anticodon binding site; other site
65093010623	Uncharacterized conserved protein [Function unknown]; Region: COG1432
65093010624	LabA_like proteins; Region: LabA; cd10911
65093010625	putative metal binding site [ion binding]; other site
65093010626	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
65093010627	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
65093010628	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
65093010629	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
65093010630	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
65093010631	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65093010632	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65093010633	G1 box; other site
65093010634	GTP/Mg2+ binding site [chemical binding]; other site
65093010635	Switch I region; other site
65093010636	G2 box; other site
65093010637	Switch II region; other site
65093010638	G3 box; other site
65093010639	G4 box; other site
65093010640	G5 box; other site
65093010641	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65093010642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65093010643	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65093010644	putative substrate translocation pore; other site
65093010645	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
65093010646	carotene isomerase; Region: carot_isom; TIGR02730
65093010647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65093010648	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65093010649	active site
65093010650	GTPase RsgA; Reviewed; Region: PRK12289
65093010651	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
65093010652	RNA binding site [nucleotide binding]; other site
65093010653	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
65093010654	GTPase/Zn-binding domain interface [polypeptide binding]; other site
65093010655	GTP/Mg2+ binding site [chemical binding]; other site
65093010656	G4 box; other site
65093010657	G5 box; other site
65093010658	G1 box; other site
65093010659	Switch I region; other site
65093010660	G2 box; other site
65093010661	G3 box; other site
65093010662	Switch II region; other site
65093010663	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
65093010664	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
65093010665	photosystem I subunit VII; Region: psaC; CHL00065
65093010666	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093010667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010668	Probable transposase; Region: OrfB_IS605; pfam01385
65093010669	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093010670	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
65093010671	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
65093010672	alpha subunit interface [polypeptide binding]; other site
65093010673	TPP binding site [chemical binding]; other site
65093010674	heterodimer interface [polypeptide binding]; other site
65093010675	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65093010676	protein-export membrane protein SecD; Region: secD; TIGR01129
65093010677	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
65093010678	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
65093010679	Protein export membrane protein; Region: SecD_SecF; pfam02355
65093010680	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
65093010681	FAD binding domain; Region: FAD_binding_4; pfam01565
65093010682	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65093010683	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
65093010684	Cysteine-rich domain; Region: CCG; pfam02754
65093010685	Cysteine-rich domain; Region: CCG; pfam02754
65093010686	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
65093010687	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
65093010688	putative valine binding site [chemical binding]; other site
65093010689	dimer interface [polypeptide binding]; other site
65093010690	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
65093010691	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
65093010692	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65093010693	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
65093010694	30S subunit binding site; other site
65093010695	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
65093010696	Protein of unknown function (DUF561); Region: DUF561; pfam04481
65093010697	DoxX; Region: DoxX; pfam07681
65093010698	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
65093010699	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
65093010700	HEAT repeats; Region: HEAT_2; pfam13646
65093010701	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
65093010702	protein binding surface [polypeptide binding]; other site
65093010703	HEAT repeats; Region: HEAT_2; pfam13646
65093010704	HEAT repeats; Region: HEAT_2; pfam13646
65093010705	CpeS-like protein; Region: CpeS; pfam09367
65093010706	S-layer homology domain; Region: SLH; pfam00395
65093010707	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65093010708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65093010709	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65093010710	Probable transposase; Region: OrfB_IS605; pfam01385
65093010711	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65093010712	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
65093010713	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
65093010714	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65093010715	FeS/SAM binding site; other site
65093010716	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093010717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093010718	active site
65093010719	phosphorylation site [posttranslational modification]
65093010720	intermolecular recognition site; other site
65093010721	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
65093010722	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65093010723	Walker A/P-loop; other site
65093010724	ATP binding site [chemical binding]; other site
65093010725	Q-loop/lid; other site
65093010726	ABC transporter signature motif; other site
65093010727	Walker B; other site
65093010728	D-loop; other site
65093010729	H-loop/switch region; other site
65093010730	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
65093010731	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
65093010732	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
65093010733	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65093010734	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65093010735	TPR repeat; Region: TPR_11; pfam13414
65093010736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093010737	binding surface
65093010738	TPR motif; other site
65093010739	TPR repeat; Region: TPR_11; pfam13414
65093010740	TPR repeat; Region: TPR_11; pfam13414
65093010741	TPR repeat; Region: TPR_11; pfam13414
65093010742	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093010743	binding surface
65093010744	TPR motif; other site
65093010745	TPR repeat; Region: TPR_11; pfam13414
65093010746	TPR repeat; Region: TPR_11; pfam13414
65093010747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65093010748	binding surface
65093010749	TPR motif; other site
65093010750	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65093010751	Cadherin repeat-like domain; Region: CA_like; cl15786
65093010752	Ca2+ binding site [ion binding]; other site
65093010753	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
65093010754	Ca2+ binding site [ion binding]; other site
65093010755	Calx-beta domain; Region: Calx-beta; cl02522
65093010756	Calx-beta domain; Region: Calx-beta; cl02522
65093010757	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010758	putative active site [active]
65093010759	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010760	putative active site [active]
65093010761	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
65093010762	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
65093010763	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
65093010764	putative active site [active]
65093010765	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
65093010766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093010767	active site
65093010768	motif I; other site
65093010769	motif II; other site
65093010770	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65093010771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093010772	active site
65093010773	phosphorylation site [posttranslational modification]
65093010774	intermolecular recognition site; other site
65093010775	dimerization interface [polypeptide binding]; other site
65093010776	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65093010777	DNA binding residues [nucleotide binding]
65093010778	dimerization interface [polypeptide binding]; other site
65093010779	seryl-tRNA synthetase; Provisional; Region: PRK05431
65093010780	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
65093010781	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
65093010782	dimer interface [polypeptide binding]; other site
65093010783	active site
65093010784	motif 1; other site
65093010785	motif 2; other site
65093010786	motif 3; other site
65093010787	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
65093010788	Predicted transcriptional regulators [Transcription]; Region: COG1695
65093010789	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
65093010790	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
65093010791	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093010792	Ligand Binding Site [chemical binding]; other site
65093010793	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
65093010794	Uncharacterized conserved protein [Function unknown]; Region: COG3937
65093010795	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65093010796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65093010797	substrate binding pocket [chemical binding]; other site
65093010798	membrane-bound complex binding site; other site
65093010799	hinge residues; other site
65093010800	PAS fold; Region: PAS_3; pfam08447
65093010801	PAS domain; Region: PAS_9; pfam13426
65093010802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093010803	putative active site [active]
65093010804	heme pocket [chemical binding]; other site
65093010805	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093010806	GAF domain; Region: GAF; pfam01590
65093010807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65093010808	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093010809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65093010810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65093010811	metal binding site [ion binding]; metal-binding site
65093010812	active site
65093010813	I-site; other site
65093010814	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
65093010815	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
65093010816	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
65093010817	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
65093010818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093010819	active site
65093010820	motif I; other site
65093010821	motif II; other site
65093010822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65093010823	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65093010824	SnoaL-like domain; Region: SnoaL_3; pfam13474
65093010825	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65093010826	classical (c) SDRs; Region: SDR_c; cd05233
65093010827	NAD(P) binding site [chemical binding]; other site
65093010828	active site
65093010829	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65093010830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093010831	PAS fold; Region: PAS_3; pfam08447
65093010832	putative active site [active]
65093010833	heme pocket [chemical binding]; other site
65093010834	PAS domain; Region: PAS_9; pfam13426
65093010835	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093010836	putative active site [active]
65093010837	heme pocket [chemical binding]; other site
65093010838	PAS fold; Region: PAS_4; pfam08448
65093010839	PAS domain S-box; Region: sensory_box; TIGR00229
65093010840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093010841	putative active site [active]
65093010842	heme pocket [chemical binding]; other site
65093010843	PAS domain S-box; Region: sensory_box; TIGR00229
65093010844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65093010845	putative active site [active]
65093010846	heme pocket [chemical binding]; other site
65093010847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65093010848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65093010849	dimer interface [polypeptide binding]; other site
65093010850	phosphorylation site [posttranslational modification]
65093010851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65093010852	ATP binding site [chemical binding]; other site
65093010853	Mg2+ binding site [ion binding]; other site
65093010854	G-X-G motif; other site
65093010855	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65093010856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65093010857	active site
65093010858	phosphorylation site [posttranslational modification]
65093010859	intermolecular recognition site; other site
65093010860	dimerization interface [polypeptide binding]; other site
65093010861	Predicted GTPase [General function prediction only]; Region: COG3596
65093010862	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65093010863	G1 box; other site
65093010864	GTP/Mg2+ binding site [chemical binding]; other site
65093010865	G2 box; other site
65093010866	Switch I region; other site
65093010867	G3 box; other site
65093010868	Switch II region; other site
65093010869	G4 box; other site
65093010870	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65093010871	putative active site [active]
65093010872	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65093010873	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65093010874	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
65093010875	Predicted GTPase [General function prediction only]; Region: COG3596
65093010876	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
65093010877	G1 box; other site
65093010878	GTP/Mg2+ binding site [chemical binding]; other site
65093010879	G2 box; other site
65093010880	Switch I region; other site
65093010881	G3 box; other site
65093010882	Switch II region; other site
65093010883	G5 box; other site
65093010884	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
65093010885	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
65093010886	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65093010887	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65093010888	phosphoenolpyruvate synthase; Validated; Region: PRK06241
65093010889	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65093010890	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65093010891	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65093010892	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65093010893	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65093010894	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65093010895	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
65093010896	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65093010897	ATP binding site [chemical binding]; other site
65093010898	Mg++ binding site [ion binding]; other site
65093010899	motif III; other site
65093010900	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65093010901	nucleotide binding region [chemical binding]; other site
65093010902	ATP-binding site [chemical binding]; other site
65093010903	threonine synthase; Reviewed; Region: PRK06721
65093010904	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
65093010905	homodimer interface [polypeptide binding]; other site
65093010906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65093010907	catalytic residue [active]
65093010908	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
65093010909	Subunit I/III interface [polypeptide binding]; other site
65093010910	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
65093010911	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
65093010912	D-pathway; other site
65093010913	Putative ubiquinol binding site [chemical binding]; other site
65093010914	Low-spin heme (heme b) binding site [chemical binding]; other site
65093010915	Putative water exit pathway; other site
65093010916	Binuclear center (heme o3/CuB) [ion binding]; other site
65093010917	K-pathway; other site
65093010918	Putative proton exit pathway; other site
65093010919	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
65093010920	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
65093010921	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
65093010922	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
65093010923	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
65093010924	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
65093010925	UbiA prenyltransferase family; Region: UbiA; pfam01040
65093010926	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65093010927	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65093010928	active site
65093010929	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
65093010930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65093010931	S-adenosylmethionine binding site [chemical binding]; other site
65093010932	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65093010933	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
65093010934	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
65093010935	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65093010936	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65093010937	active site
65093010938	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65093010939	ABC1 family; Region: ABC1; cl17513
65093010940	GH3 auxin-responsive promoter; Region: GH3; pfam03321
65093010941	Cupin-like domain; Region: Cupin_8; pfam13621
65093010942	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
65093010943	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
65093010944	Protein of unknown function (DUF962); Region: DUF962; pfam06127
65093010945	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
65093010946	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65093010947	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65093010948	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65093010949	Ligand Binding Site [chemical binding]; other site
65093010950	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093010951	Ligand Binding Site [chemical binding]; other site
65093010952	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
65093010953	ligand binding site [chemical binding]; other site
65093010954	Tubulin like; Region: Tubulin_2; pfam13809
65093010955	Short C-terminal domain; Region: SHOCT; pfam09851
65093010956	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
65093010957	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65093010958	von Willebrand factor type A domain; Region: VWA_2; pfam13519
65093010959	metal ion-dependent adhesion site (MIDAS); other site
65093010960	Phosphotransferase enzyme family; Region: APH; pfam01636
65093010961	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65093010962	active site
65093010963	ATP binding site [chemical binding]; other site
65093010964	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
65093010965	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65093010966	protein I interface; other site
65093010967	D2 interface; other site
65093010968	protein T interface; other site
65093010969	chlorophyll binding site; other site
65093010970	beta carotene binding site; other site
65093010971	pheophytin binding site; other site
65093010972	manganese-stabilizing polypeptide interface; other site
65093010973	CP43 interface; other site
65093010974	protein L interface; other site
65093010975	oxygen evolving complex binding site; other site
65093010976	bromide binding site; other site
65093010977	quinone binding site; other site
65093010978	Fe binding site [ion binding]; other site
65093010979	core light harvesting interface; other site
65093010980	cytochrome b559 alpha subunit interface; other site
65093010981	cytochrome c-550 interface; other site
65093010982	protein J interface; other site
65093010983	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
65093010984	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
65093010985	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65093010986	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
65093010987	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
65093010988	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65093010989	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
65093010990	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65093010991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65093010992	Coenzyme A binding pocket [chemical binding]; other site
65093010993	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65093010994	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093010995	Ligand Binding Site [chemical binding]; other site
65093010996	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65093010997	Ligand Binding Site [chemical binding]; other site
65093010998	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
65093010999	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705