-- dump date 20140619_112220 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1206745000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1206745000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1206745000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000004 Walker A motif; other site 1206745000005 ATP binding site [chemical binding]; other site 1206745000006 Walker B motif; other site 1206745000007 arginine finger; other site 1206745000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1206745000009 DnaA box-binding interface [nucleotide binding]; other site 1206745000010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206745000011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745000012 putative substrate translocation pore; other site 1206745000013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206745000014 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1206745000015 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1206745000016 generic binding surface II; other site 1206745000017 ssDNA binding site; other site 1206745000018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745000019 ATP binding site [chemical binding]; other site 1206745000020 putative Mg++ binding site [ion binding]; other site 1206745000021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745000022 nucleotide binding region [chemical binding]; other site 1206745000023 ATP-binding site [chemical binding]; other site 1206745000024 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1206745000025 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1206745000026 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1206745000027 short chain dehydrogenase; Provisional; Region: PRK07024 1206745000028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745000029 NAD(P) binding site [chemical binding]; other site 1206745000030 active site 1206745000031 Sulfatase; Region: Sulfatase; pfam00884 1206745000032 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206745000033 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206745000034 catalytic residues [active] 1206745000035 Predicted membrane protein [Function unknown]; Region: COG2855 1206745000036 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1206745000037 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971 1206745000038 putative active site [active] 1206745000039 putative metal binding site [ion binding]; other site 1206745000040 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1206745000041 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1206745000042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000043 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 1206745000044 FeS/SAM binding site; other site 1206745000045 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1206745000046 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1206745000047 classical (c) SDRs; Region: SDR_c; cd05233 1206745000048 NAD(P) binding site [chemical binding]; other site 1206745000049 active site 1206745000050 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206745000051 TPP-binding site [chemical binding]; other site 1206745000052 dimer interface [polypeptide binding]; other site 1206745000053 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1206745000054 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206745000055 PYR/PP interface [polypeptide binding]; other site 1206745000056 dimer interface [polypeptide binding]; other site 1206745000057 TPP binding site [chemical binding]; other site 1206745000058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206745000059 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1206745000060 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1206745000061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745000062 acyl-activating enzyme (AAE) consensus motif; other site 1206745000063 AMP binding site [chemical binding]; other site 1206745000064 active site 1206745000065 CoA binding site [chemical binding]; other site 1206745000066 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1206745000067 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1206745000068 NAD(P) binding site [chemical binding]; other site 1206745000069 catalytic residues [active] 1206745000070 Cache domain; Region: Cache_1; pfam02743 1206745000071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745000072 putative CheW interface [polypeptide binding]; other site 1206745000073 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1206745000074 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1206745000075 putative NAD(P) binding site [chemical binding]; other site 1206745000076 putative substrate binding site [chemical binding]; other site 1206745000077 catalytic Zn binding site [ion binding]; other site 1206745000078 structural Zn binding site [ion binding]; other site 1206745000079 dimer interface [polypeptide binding]; other site 1206745000080 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1206745000081 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1206745000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745000083 S-adenosylmethionine binding site [chemical binding]; other site 1206745000084 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206745000085 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206745000086 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206745000087 hypothetical protein; Provisional; Region: PRK10621 1206745000088 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1206745000089 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 1206745000090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206745000091 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1206745000092 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1206745000093 Mg++ binding site [ion binding]; other site 1206745000094 putative catalytic motif [active] 1206745000095 putative substrate binding site [chemical binding]; other site 1206745000096 phosphoglyceromutase; Provisional; Region: PRK05434 1206745000097 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1206745000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1206745000099 Fic/DOC family; Region: Fic; cl00960 1206745000100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1206745000101 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1206745000102 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1206745000103 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1206745000104 N-terminal plug; other site 1206745000105 ligand-binding site [chemical binding]; other site 1206745000106 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1206745000107 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1206745000108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206745000109 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1206745000110 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206745000111 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1206745000112 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1206745000113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206745000114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206745000115 DNA binding residues [nucleotide binding] 1206745000116 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1206745000117 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1206745000118 flagellar motor switch protein FliY; Validated; Region: PRK08432 1206745000119 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1206745000120 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1206745000121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206745000122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206745000123 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1206745000124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1206745000125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745000126 dimer interface [polypeptide binding]; other site 1206745000127 putative CheW interface [polypeptide binding]; other site 1206745000128 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1206745000129 Dynamin family; Region: Dynamin_N; pfam00350 1206745000130 G1 box; other site 1206745000131 GTP/Mg2+ binding site [chemical binding]; other site 1206745000132 G2 box; other site 1206745000133 Switch I region; other site 1206745000134 G3 box; other site 1206745000135 Switch II region; other site 1206745000136 G4 box; other site 1206745000137 G5 box; other site 1206745000138 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1206745000139 Dynamin family; Region: Dynamin_N; pfam00350 1206745000140 G1 box; other site 1206745000141 GTP/Mg2+ binding site [chemical binding]; other site 1206745000142 G2 box; other site 1206745000143 Switch I region; other site 1206745000144 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1206745000145 G3 box; other site 1206745000146 Switch II region; other site 1206745000147 GTP/Mg2+ binding site [chemical binding]; other site 1206745000148 G4 box; other site 1206745000149 G5 box; other site 1206745000150 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1206745000151 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1206745000152 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1206745000153 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1206745000154 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1206745000155 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1206745000156 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1206745000157 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1206745000158 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1206745000159 trimer interface [polypeptide binding]; other site 1206745000160 active site 1206745000161 UDP-GlcNAc binding site [chemical binding]; other site 1206745000162 lipid binding site [chemical binding]; lipid-binding site 1206745000163 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1206745000164 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1206745000165 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1206745000166 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745000167 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745000168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1206745000169 ATP binding site [chemical binding]; other site 1206745000170 Mg2+ binding site [ion binding]; other site 1206745000171 G-X-G motif; other site 1206745000172 Virulence protein [General function prediction only]; Region: COG3943 1206745000173 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1206745000174 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206745000175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206745000176 ATP binding site [chemical binding]; other site 1206745000177 putative Mg++ binding site [ion binding]; other site 1206745000178 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1206745000179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745000180 dimer interface [polypeptide binding]; other site 1206745000181 putative CheW interface [polypeptide binding]; other site 1206745000182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745000183 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1206745000184 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206745000185 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206745000186 metal-binding site [ion binding] 1206745000187 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206745000188 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206745000189 hypothetical protein; Provisional; Region: PRK08444 1206745000190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000191 FeS/SAM binding site; other site 1206745000192 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1206745000193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000194 FeS/SAM binding site; other site 1206745000195 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1206745000196 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1206745000197 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1206745000198 GTP binding site; other site 1206745000199 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1206745000200 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1206745000201 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206745000202 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745000203 septum formation inhibitor; Reviewed; Region: minC; PRK00556 1206745000204 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1206745000205 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1206745000206 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1206745000207 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1206745000208 homoserine kinase; Provisional; Region: PRK01212 1206745000209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206745000210 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1206745000211 putative RNA binding cleft [nucleotide binding]; other site 1206745000212 translation initiation factor IF-2; Region: IF-2; TIGR00487 1206745000213 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1206745000214 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1206745000215 G1 box; other site 1206745000216 putative GEF interaction site [polypeptide binding]; other site 1206745000217 GTP/Mg2+ binding site [chemical binding]; other site 1206745000218 Switch I region; other site 1206745000219 G2 box; other site 1206745000220 G3 box; other site 1206745000221 Switch II region; other site 1206745000222 G4 box; other site 1206745000223 G5 box; other site 1206745000224 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1206745000225 Translation-initiation factor 2; Region: IF-2; pfam11987 1206745000226 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1206745000227 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1206745000228 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1206745000229 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1206745000230 catalytic triad [active] 1206745000231 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1206745000232 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1206745000233 homodimer interface [polypeptide binding]; other site 1206745000234 NAD synthetase; Provisional; Region: PRK13980 1206745000235 NAD binding pocket [chemical binding]; other site 1206745000236 ATP binding pocket [chemical binding]; other site 1206745000237 Mg binding site [ion binding]; other site 1206745000238 active-site loop [active] 1206745000239 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1206745000240 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1206745000241 iron-sulfur cluster [ion binding]; other site 1206745000242 [2Fe-2S] cluster binding site [ion binding]; other site 1206745000243 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1206745000244 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1206745000245 intrachain domain interface; other site 1206745000246 interchain domain interface [polypeptide binding]; other site 1206745000247 heme bH binding site [chemical binding]; other site 1206745000248 Qi binding site; other site 1206745000249 heme bL binding site [chemical binding]; other site 1206745000250 Qo binding site; other site 1206745000251 interchain domain interface [polypeptide binding]; other site 1206745000252 intrachain domain interface; other site 1206745000253 Qi binding site; other site 1206745000254 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1206745000255 Qo binding site; other site 1206745000256 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1206745000257 Cytochrome c; Region: Cytochrom_C; pfam00034 1206745000258 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1206745000259 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1206745000260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745000261 Walker A/P-loop; other site 1206745000262 ATP binding site [chemical binding]; other site 1206745000263 Q-loop/lid; other site 1206745000264 ABC transporter signature motif; other site 1206745000265 Walker B; other site 1206745000266 D-loop; other site 1206745000267 H-loop/switch region; other site 1206745000268 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1206745000269 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206745000270 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1206745000271 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1206745000272 active site 1206745000273 catalytic triad [active] 1206745000274 oxyanion hole [active] 1206745000275 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1206745000276 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1206745000277 active site 1206745000278 oxyanion hole [active] 1206745000279 catalytic triad [active] 1206745000280 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1206745000281 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1206745000282 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745000283 Predicted membrane protein [Function unknown]; Region: COG2860 1206745000284 UPF0126 domain; Region: UPF0126; pfam03458 1206745000285 UPF0126 domain; Region: UPF0126; pfam03458 1206745000286 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 1206745000287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000288 Walker A motif; other site 1206745000289 ATP binding site [chemical binding]; other site 1206745000290 Walker B motif; other site 1206745000291 arginine finger; other site 1206745000292 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1206745000293 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1206745000294 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1206745000295 Walker A/P-loop; other site 1206745000296 ATP binding site [chemical binding]; other site 1206745000297 Q-loop/lid; other site 1206745000298 ABC transporter signature motif; other site 1206745000299 Walker B; other site 1206745000300 D-loop; other site 1206745000301 H-loop/switch region; other site 1206745000302 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1206745000303 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1206745000304 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1206745000305 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1206745000306 ICEA Protein; Region: ICEA; pfam05315 1206745000307 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1206745000308 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 1206745000309 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1206745000310 rRNA interaction site [nucleotide binding]; other site 1206745000311 S8 interaction site; other site 1206745000312 putative laminin-1 binding site; other site 1206745000313 elongation factor Ts; Provisional; Region: tsf; PRK09377 1206745000314 UBA/TS-N domain; Region: UBA; pfam00627 1206745000315 Elongation factor TS; Region: EF_TS; pfam00889 1206745000316 Elongation factor TS; Region: EF_TS; pfam00889 1206745000317 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1206745000318 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1206745000319 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1206745000320 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1206745000321 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1206745000322 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1206745000323 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1206745000324 NAD(P) binding pocket [chemical binding]; other site 1206745000325 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1206745000326 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1206745000327 catalytic residue [active] 1206745000328 putative FPP diphosphate binding site; other site 1206745000329 putative FPP binding hydrophobic cleft; other site 1206745000330 dimer interface [polypeptide binding]; other site 1206745000331 putative IPP diphosphate binding site; other site 1206745000332 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1206745000333 putative trimer interface [polypeptide binding]; other site 1206745000334 putative active site [active] 1206745000335 putative substrate binding site [chemical binding]; other site 1206745000336 putative CoA binding site [chemical binding]; other site 1206745000337 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745000338 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1206745000339 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1206745000340 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745000341 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1206745000342 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1206745000343 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 1206745000344 catalytic residues [active] 1206745000345 ferrochelatase; Reviewed; Region: hemH; PRK00035 1206745000346 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1206745000347 active site 1206745000348 C-terminal domain interface [polypeptide binding]; other site 1206745000349 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1206745000350 active site 1206745000351 N-terminal domain interface [polypeptide binding]; other site 1206745000352 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1206745000353 RNA methyltransferase, RsmE family; Region: TIGR00046 1206745000354 prephenate dehydrogenase; Validated; Region: PRK08507 1206745000355 Prephenate dehydrogenase; Region: PDH; pfam02153 1206745000356 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1206745000357 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1206745000358 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1206745000359 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1206745000360 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1206745000361 Surface antigen; Region: Bac_surface_Ag; pfam01103 1206745000362 hypothetical protein; Provisional; Region: PRK08445 1206745000363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000364 FeS/SAM binding site; other site 1206745000365 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1206745000366 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1206745000367 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1206745000368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745000369 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745000370 Ion transport protein; Region: Ion_trans; pfam00520 1206745000371 Ion transport protein; Region: Ion_trans; pfam00520 1206745000372 TM2 domain; Region: TM2; pfam05154 1206745000373 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206745000374 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1206745000375 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1206745000376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206745000377 nucleotide binding site [chemical binding]; other site 1206745000378 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 1206745000379 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1206745000380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1206745000381 putative acyl-acceptor binding pocket; other site 1206745000382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000383 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1206745000384 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000385 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000386 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745000387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206745000388 active site 1206745000389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 1206745000390 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1206745000391 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206745000392 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206745000393 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 1206745000394 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1206745000395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000396 FeS/SAM binding site; other site 1206745000397 HemN C-terminal domain; Region: HemN_C; pfam06969 1206745000398 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1206745000399 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206745000400 Cysteine-rich domain; Region: CCG; pfam02754 1206745000401 Cysteine-rich domain; Region: CCG; pfam02754 1206745000402 HDOD domain; Region: HDOD; pfam08668 1206745000403 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1206745000404 thiS-thiF/thiG interaction site; other site 1206745000405 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 1206745000406 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1206745000407 Substrate binding site; other site 1206745000408 Mg++ binding site; other site 1206745000409 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1206745000410 active site 1206745000411 substrate binding site [chemical binding]; other site 1206745000412 CoA binding site [chemical binding]; other site 1206745000413 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1206745000414 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1206745000415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745000416 S-adenosylmethionine binding site [chemical binding]; other site 1206745000417 SurA N-terminal domain; Region: SurA_N; pfam09312 1206745000418 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1206745000419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1206745000420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1206745000421 binding surface 1206745000422 TPR motif; other site 1206745000423 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1206745000424 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1206745000425 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206745000426 active site 1206745000427 ribonuclease III; Reviewed; Region: rnc; PRK00102 1206745000428 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1206745000429 dimerization interface [polypeptide binding]; other site 1206745000430 active site 1206745000431 metal binding site [ion binding]; metal-binding site 1206745000432 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1206745000433 dsRNA binding site [nucleotide binding]; other site 1206745000434 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1206745000435 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1206745000436 Tetramer interface [polypeptide binding]; other site 1206745000437 active site 1206745000438 FMN-binding site [chemical binding]; other site 1206745000439 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1206745000440 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1206745000441 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1206745000442 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206745000443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1206745000444 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1206745000445 active site 1206745000446 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1206745000447 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1206745000448 META domain; Region: META; pfam03724 1206745000449 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1206745000450 generic binding surface I; other site 1206745000451 generic binding surface II; other site 1206745000452 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1206745000453 PHP domain; Region: PHP; pfam02811 1206745000454 active site 1206745000455 PHP Thumb interface [polypeptide binding]; other site 1206745000456 metal binding site [ion binding]; metal-binding site 1206745000457 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1206745000458 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 1206745000459 NusA N-terminal domain; Region: NusA_N; pfam08529 1206745000460 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1206745000461 RNA binding site [nucleotide binding]; other site 1206745000462 homodimer interface [polypeptide binding]; other site 1206745000463 NusA-like KH domain; Region: KH_5; pfam13184 1206745000464 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1206745000465 G-X-X-G motif; other site 1206745000466 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1206745000467 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1206745000468 trimer interface [polypeptide binding]; other site 1206745000469 active site 1206745000470 dimer interface [polypeptide binding]; other site 1206745000471 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206745000472 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1206745000473 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1206745000474 active site 1206745000475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 1206745000476 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1206745000477 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1206745000478 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 1206745000479 RimM N-terminal domain; Region: RimM; pfam01782 1206745000480 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1206745000481 KH domain; Region: KH_4; pfam13083 1206745000482 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1206745000483 signal recognition particle protein; Provisional; Region: PRK10867 1206745000484 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1206745000485 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1206745000486 P loop; other site 1206745000487 GTP binding site [chemical binding]; other site 1206745000488 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1206745000489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206745000490 metal binding site 2 [ion binding]; metal-binding site 1206745000491 putative DNA binding helix; other site 1206745000492 metal binding site 1 [ion binding]; metal-binding site 1206745000493 dimer interface [polypeptide binding]; other site 1206745000494 structural Zn2+ binding site [ion binding]; other site 1206745000495 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206745000496 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1206745000497 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206745000498 active site residue [active] 1206745000499 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1206745000500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206745000501 active site 1206745000502 HIGH motif; other site 1206745000503 nucleotide binding site [chemical binding]; other site 1206745000504 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206745000505 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1206745000506 active site 1206745000507 KMSKS motif; other site 1206745000508 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1206745000509 tRNA binding surface [nucleotide binding]; other site 1206745000510 anticodon binding site; other site 1206745000511 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1206745000512 FliW protein; Region: FliW; cl00740 1206745000513 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1206745000514 Part of AAA domain; Region: AAA_19; pfam13245 1206745000515 Family description; Region: UvrD_C_2; pfam13538 1206745000516 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1206745000517 Flagellin N-methylase; Region: FliB; pfam03692 1206745000518 DDE superfamily endonuclease; Region: DDE_5; cl17874 1206745000519 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1206745000520 ligand binding site [chemical binding]; other site 1206745000521 active site 1206745000522 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1206745000523 active site 1206745000524 putative catalytic site [active] 1206745000525 DNA binding site [nucleotide binding] 1206745000526 putative phosphate binding site [ion binding]; other site 1206745000527 metal binding site A [ion binding]; metal-binding site 1206745000528 AP binding site [nucleotide binding]; other site 1206745000529 metal binding site B [ion binding]; metal-binding site 1206745000530 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206745000531 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1206745000532 Lysine efflux permease [General function prediction only]; Region: COG1279 1206745000533 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1206745000534 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1206745000535 active site 1206745000536 homodimer interface [polypeptide binding]; other site 1206745000537 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1206745000538 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206745000539 active site 1206745000540 HIGH motif; other site 1206745000541 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206745000542 active site 1206745000543 KMSKS motif; other site 1206745000544 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1206745000545 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206745000546 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1206745000547 Dihydroneopterin aldolase; Region: FolB; pfam02152 1206745000548 active site 1206745000549 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1206745000550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206745000551 active site residue [active] 1206745000552 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1206745000553 Competence-damaged protein; Region: CinA; pfam02464 1206745000554 heat-inducible transcription repressor; Provisional; Region: PRK03911 1206745000555 heat shock protein GrpE; Provisional; Region: PRK14140 1206745000556 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1206745000557 dimer interface [polypeptide binding]; other site 1206745000558 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1206745000559 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1206745000560 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1206745000561 nucleotide binding site [chemical binding]; other site 1206745000562 NEF interaction site [polypeptide binding]; other site 1206745000563 SBD interface [polypeptide binding]; other site 1206745000564 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1206745000565 active site 1206745000566 homotetramer interface [polypeptide binding]; other site 1206745000567 homodimer interface [polypeptide binding]; other site 1206745000568 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 1206745000569 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1206745000570 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1206745000571 tetramer interface [polypeptide binding]; other site 1206745000572 heme binding pocket [chemical binding]; other site 1206745000573 NADPH binding site [chemical binding]; other site 1206745000574 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206745000575 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1206745000576 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1206745000577 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1206745000578 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206745000579 RF-1 domain; Region: RF-1; pfam00472 1206745000580 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1206745000581 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206745000582 putative active site [active] 1206745000583 YopX protein; Region: YopX; cl09859 1206745000584 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1206745000585 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1206745000586 intersubunit interface [polypeptide binding]; other site 1206745000587 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1206745000588 N-terminal plug; other site 1206745000589 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1206745000590 ligand-binding site [chemical binding]; other site 1206745000591 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1206745000592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206745000593 ABC-ATPase subunit interface; other site 1206745000594 dimer interface [polypeptide binding]; other site 1206745000595 putative PBP binding regions; other site 1206745000596 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1206745000597 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1206745000598 Walker A/P-loop; other site 1206745000599 ATP binding site [chemical binding]; other site 1206745000600 Q-loop/lid; other site 1206745000601 ABC transporter signature motif; other site 1206745000602 Walker B; other site 1206745000603 D-loop; other site 1206745000604 H-loop/switch region; other site 1206745000605 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1206745000606 Predicted transcriptional regulator [Transcription]; Region: COG3905 1206745000607 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206745000608 AAA domain; Region: AAA_25; pfam13481 1206745000609 Walker B motif; other site 1206745000610 ParA-like protein; Provisional; Region: PHA02518 1206745000611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206745000612 P-loop; other site 1206745000613 Magnesium ion binding site [ion binding]; other site 1206745000614 Protein of unknown function DUF86; Region: DUF86; cl01031 1206745000615 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1206745000616 active site 1206745000617 NTP binding site [chemical binding]; other site 1206745000618 metal binding triad [ion binding]; metal-binding site 1206745000619 antibiotic binding site [chemical binding]; other site 1206745000620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745000621 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745000622 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206745000623 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745000624 inhibitor-cofactor binding pocket; inhibition site 1206745000625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745000626 catalytic residue [active] 1206745000627 shikimate kinase; Reviewed; Region: aroK; PRK00131 1206745000628 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1206745000629 ADP binding site [chemical binding]; other site 1206745000630 magnesium binding site [ion binding]; other site 1206745000631 putative shikimate binding site; other site 1206745000632 AMIN domain; Region: AMIN; pfam11741 1206745000633 enolase; Provisional; Region: eno; PRK00077 1206745000634 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1206745000635 dimer interface [polypeptide binding]; other site 1206745000636 metal binding site [ion binding]; metal-binding site 1206745000637 substrate binding pocket [chemical binding]; other site 1206745000638 recombinase A; Provisional; Region: recA; PRK09354 1206745000639 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1206745000640 hexamer interface [polypeptide binding]; other site 1206745000641 Walker A motif; other site 1206745000642 ATP binding site [chemical binding]; other site 1206745000643 Walker B motif; other site 1206745000644 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1206745000645 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206745000646 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206745000647 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1206745000648 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1206745000649 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1206745000650 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1206745000651 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206745000652 homodimer interface [polypeptide binding]; other site 1206745000653 substrate-cofactor binding pocket; other site 1206745000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745000655 catalytic residue [active] 1206745000656 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1206745000657 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1206745000658 proposed active site lysine [active] 1206745000659 conserved cys residue [active] 1206745000660 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1206745000661 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1206745000662 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1206745000663 Putative zinc ribbon domain; Region: DUF164; pfam02591 1206745000664 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1206745000665 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1206745000666 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206745000667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1206745000668 RNA binding surface [nucleotide binding]; other site 1206745000669 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206745000670 active site 1206745000671 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1206745000672 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1206745000673 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1206745000674 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1206745000675 Outer membrane efflux protein; Region: OEP; pfam02321 1206745000676 Outer membrane efflux protein; Region: OEP; pfam02321 1206745000677 dihydropteroate synthase; Region: DHPS; TIGR01496 1206745000678 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1206745000679 substrate binding pocket [chemical binding]; other site 1206745000680 dimer interface [polypeptide binding]; other site 1206745000681 inhibitor binding site; inhibition site 1206745000682 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1206745000683 DNA replication regulator; Region: HobA; pfam12163 1206745000684 aspartate kinase; Reviewed; Region: PRK06635 1206745000685 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1206745000686 putative catalytic residues [active] 1206745000687 putative nucleotide binding site [chemical binding]; other site 1206745000688 putative aspartate binding site [chemical binding]; other site 1206745000689 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1206745000690 putative allosteric regulatory site; other site 1206745000691 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1206745000692 putative allosteric regulatory residue; other site 1206745000693 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1206745000694 putative active site [active] 1206745000695 Ap4A binding site [chemical binding]; other site 1206745000696 nudix motif; other site 1206745000697 putative metal binding site [ion binding]; other site 1206745000698 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 1206745000699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745000700 FeS/SAM binding site; other site 1206745000701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206745000705 Walker A motif; other site 1206745000706 ATP binding site [chemical binding]; other site 1206745000707 Walker B motif; other site 1206745000708 arginine finger; other site 1206745000709 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206745000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000711 Walker A motif; other site 1206745000712 ATP binding site [chemical binding]; other site 1206745000713 Walker B motif; other site 1206745000714 arginine finger; other site 1206745000715 Protein of unknown function DUF262; Region: DUF262; pfam03235 1206745000716 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1206745000717 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1206745000718 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1206745000719 oligomeric interface; other site 1206745000720 putative active site [active] 1206745000721 homodimer interface [polypeptide binding]; other site 1206745000722 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1206745000723 HTH domain; Region: HTH_11; cl17392 1206745000724 Predicted transcriptional regulator [Transcription]; Region: COG2378 1206745000725 WYL domain; Region: WYL; cl14852 1206745000726 WYL domain; Region: WYL; pfam13280 1206745000727 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1206745000728 Peptidase family U32; Region: Peptidase_U32; pfam01136 1206745000729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745000730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206745000731 Walker A/P-loop; other site 1206745000732 ATP binding site [chemical binding]; other site 1206745000733 Q-loop/lid; other site 1206745000734 ABC transporter signature motif; other site 1206745000735 Walker B; other site 1206745000736 D-loop; other site 1206745000737 H-loop/switch region; other site 1206745000738 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1206745000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745000740 dimer interface [polypeptide binding]; other site 1206745000741 conserved gate region; other site 1206745000742 putative PBP binding loops; other site 1206745000743 ABC-ATPase subunit interface; other site 1206745000744 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1206745000745 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1206745000746 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1206745000747 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1206745000748 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1206745000749 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1206745000750 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206745000751 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1206745000752 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1206745000753 Cysteine-rich domain; Region: CCG; pfam02754 1206745000754 Cysteine-rich domain; Region: CCG; pfam02754 1206745000755 L-lactate permease; Region: Lactate_perm; cl00701 1206745000756 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1206745000757 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 1206745000758 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206745000759 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1206745000760 NAD binding site [chemical binding]; other site 1206745000761 putative substrate binding site 2 [chemical binding]; other site 1206745000762 putative substrate binding site 1 [chemical binding]; other site 1206745000763 active site 1206745000764 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1206745000765 hypothetical protein; Provisional; Region: PRK07208 1206745000766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206745000767 UDP-galactopyranose mutase; Region: GLF; pfam03275 1206745000768 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1206745000769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745000770 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1206745000771 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1206745000772 NAD binding site [chemical binding]; other site 1206745000773 homodimer interface [polypeptide binding]; other site 1206745000774 active site 1206745000775 substrate binding site [chemical binding]; other site 1206745000776 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 1206745000777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000781 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1206745000782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000783 putative ADP-binding pocket [chemical binding]; other site 1206745000784 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745000785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206745000786 active site 1206745000787 Sulfatase; Region: Sulfatase; cl17466 1206745000788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745000789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206745000790 active site 1206745000791 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745000792 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745000794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745000795 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1206745000796 metal-binding site 1206745000797 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1206745000798 active site 1206745000799 substrate binding pocket [chemical binding]; other site 1206745000800 dimer interface [polypeptide binding]; other site 1206745000801 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1206745000802 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1206745000803 active site 1206745000804 substrate binding site [chemical binding]; other site 1206745000805 metal binding site [ion binding]; metal-binding site 1206745000806 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1206745000807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206745000808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745000809 homodimer interface [polypeptide binding]; other site 1206745000810 catalytic residue [active] 1206745000811 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1206745000812 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1206745000813 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1206745000814 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1206745000815 FliG C-terminal domain; Region: FliG_C; pfam01706 1206745000816 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1206745000817 Flagellar assembly protein FliH; Region: FliH; pfam02108 1206745000818 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1206745000819 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1206745000820 TPP-binding site; other site 1206745000821 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206745000822 PYR/PP interface [polypeptide binding]; other site 1206745000823 dimer interface [polypeptide binding]; other site 1206745000824 TPP binding site [chemical binding]; other site 1206745000825 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206745000826 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1206745000827 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1206745000828 dimer interface [polypeptide binding]; other site 1206745000829 putative radical transfer pathway; other site 1206745000830 diiron center [ion binding]; other site 1206745000831 tyrosyl radical; other site 1206745000832 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1206745000833 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1206745000834 active site 1206745000835 catalytic triad [active] 1206745000836 dimer interface [polypeptide binding]; other site 1206745000837 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1206745000838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745000839 S-adenosylmethionine binding site [chemical binding]; other site 1206745000840 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1206745000841 Predicted permeases [General function prediction only]; Region: COG0795 1206745000842 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1206745000843 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1206745000844 dimerization interface 3.5A [polypeptide binding]; other site 1206745000845 active site 1206745000846 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1206745000847 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1206745000848 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1206745000849 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1206745000850 RDD family; Region: RDD; cl00746 1206745000851 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1206745000852 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1206745000853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745000854 active site 1206745000855 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1206745000856 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1206745000857 oligomer interface [polypeptide binding]; other site 1206745000858 RNA binding site [nucleotide binding]; other site 1206745000859 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1206745000860 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1206745000861 oligomer interface [polypeptide binding]; other site 1206745000862 RNA binding site [nucleotide binding]; other site 1206745000863 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1206745000864 putative nucleic acid binding region [nucleotide binding]; other site 1206745000865 G-X-X-G motif; other site 1206745000866 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1206745000867 RNA binding site [nucleotide binding]; other site 1206745000868 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 1206745000869 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1206745000870 DNA repair protein RadA; Provisional; Region: PRK11823 1206745000871 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1206745000872 Walker A motif/ATP binding site; other site 1206745000873 ATP binding site [chemical binding]; other site 1206745000874 Walker B motif; other site 1206745000875 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1206745000876 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1206745000877 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1206745000878 P loop; other site 1206745000879 GTP binding site [chemical binding]; other site 1206745000880 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1206745000881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206745000882 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1206745000883 phosphodiesterase; Provisional; Region: PRK12704 1206745000884 KH domain; Region: KH_1; pfam00013 1206745000885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206745000886 Zn2+ binding site [ion binding]; other site 1206745000887 Mg2+ binding site [ion binding]; other site 1206745000888 putative arabinose transporter; Provisional; Region: PRK03545 1206745000889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745000890 putative substrate translocation pore; other site 1206745000891 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1206745000892 Sel1-like repeats; Region: SEL1; smart00671 1206745000893 Sel1-like repeats; Region: SEL1; smart00671 1206745000894 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1206745000895 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1206745000896 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1206745000897 FMN binding site [chemical binding]; other site 1206745000898 active site 1206745000899 catalytic residues [active] 1206745000900 substrate binding site [chemical binding]; other site 1206745000901 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1206745000902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1206745000903 dimer interface [polypeptide binding]; other site 1206745000904 active site 1206745000905 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206745000906 catalytic residues [active] 1206745000907 substrate binding site [chemical binding]; other site 1206745000908 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1206745000909 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1206745000910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745000911 active site 1206745000912 phosphorylation site [posttranslational modification] 1206745000913 intermolecular recognition site; other site 1206745000914 dimerization interface [polypeptide binding]; other site 1206745000915 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1206745000916 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1206745000917 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1206745000918 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1206745000919 FtsH Extracellular; Region: FtsH_ext; pfam06480 1206745000920 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1206745000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000922 Walker A motif; other site 1206745000923 ATP binding site [chemical binding]; other site 1206745000924 Walker B motif; other site 1206745000925 arginine finger; other site 1206745000926 Peptidase family M41; Region: Peptidase_M41; pfam01434 1206745000927 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1206745000928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745000929 S-adenosylmethionine binding site [chemical binding]; other site 1206745000930 Response regulator receiver domain; Region: Response_reg; pfam00072 1206745000931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745000932 active site 1206745000933 phosphorylation site [posttranslational modification] 1206745000934 intermolecular recognition site; other site 1206745000935 dimerization interface [polypeptide binding]; other site 1206745000936 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1206745000937 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1206745000938 catalytic residues [active] 1206745000939 Securin sister-chromatid separation inhibitor; Region: Securin; pfam04856 1206745000940 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1206745000941 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1206745000942 active site 1206745000943 metal binding site [ion binding]; metal-binding site 1206745000944 Nitronate monooxygenase; Region: NMO; pfam03060 1206745000945 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206745000946 FMN binding site [chemical binding]; other site 1206745000947 substrate binding site [chemical binding]; other site 1206745000948 putative catalytic residue [active] 1206745000949 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1206745000950 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1206745000951 active site 1206745000952 HIGH motif; other site 1206745000953 dimer interface [polypeptide binding]; other site 1206745000954 KMSKS motif; other site 1206745000955 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206745000956 RNA binding surface [nucleotide binding]; other site 1206745000957 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1206745000958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206745000959 Zn2+ binding site [ion binding]; other site 1206745000960 Mg2+ binding site [ion binding]; other site 1206745000961 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1206745000962 synthetase active site [active] 1206745000963 NTP binding site [chemical binding]; other site 1206745000964 metal binding site [ion binding]; metal-binding site 1206745000965 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1206745000966 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1206745000967 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1206745000968 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1206745000969 putative nucleotide binding site [chemical binding]; other site 1206745000970 uridine monophosphate binding site [chemical binding]; other site 1206745000971 homohexameric interface [polypeptide binding]; other site 1206745000972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745000973 S-adenosylmethionine binding site [chemical binding]; other site 1206745000974 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1206745000975 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1206745000976 catalytic motif [active] 1206745000977 Zn binding site [ion binding]; other site 1206745000978 RibD C-terminal domain; Region: RibD_C; cl17279 1206745000979 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1206745000980 Sm and related proteins; Region: Sm_like; cl00259 1206745000981 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1206745000982 putative oligomer interface [polypeptide binding]; other site 1206745000983 putative RNA binding site [nucleotide binding]; other site 1206745000984 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1206745000985 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1206745000986 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1206745000987 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1206745000988 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1206745000989 flagellar assembly protein FliW; Provisional; Region: PRK13282 1206745000990 Tetratricopeptide repeat; Region: TPR_18; pfam13512 1206745000991 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1206745000992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745000993 Walker A motif; other site 1206745000994 ATP binding site [chemical binding]; other site 1206745000995 Walker B motif; other site 1206745000996 arginine finger; other site 1206745000997 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1206745000998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745000999 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206745001000 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206745001001 dimer interface [polypeptide binding]; other site 1206745001002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745001003 catalytic residue [active] 1206745001004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745001005 Dehydratase family; Region: ILVD_EDD; cl00340 1206745001006 Dehydratase family; Region: ILVD_EDD; cl00340 1206745001007 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206745001008 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206745001009 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1206745001010 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206745001011 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1206745001012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745001013 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1206745001014 FeS/SAM binding site; other site 1206745001015 AAA domain; Region: AAA_17; pfam13207 1206745001016 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1206745001017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745001018 active site 1206745001019 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206745001020 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206745001021 metal-binding site [ion binding] 1206745001022 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206745001023 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206745001024 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 1206745001025 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 1206745001026 glutamine synthetase, type I; Region: GlnA; TIGR00653 1206745001027 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1206745001028 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206745001029 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1206745001030 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1206745001031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206745001032 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1206745001033 active site 1206745001034 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1206745001035 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1206745001036 active site 1206745001037 HIGH motif; other site 1206745001038 dimer interface [polypeptide binding]; other site 1206745001039 KMSKS motif; other site 1206745001040 pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844 1206745001041 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 1206745001042 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 1206745001043 4Fe-4S binding domain; Region: Fer4; cl02805 1206745001044 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 1206745001045 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1206745001046 dimer interface [polypeptide binding]; other site 1206745001047 PYR/PP interface [polypeptide binding]; other site 1206745001048 TPP binding site [chemical binding]; other site 1206745001049 substrate binding site [chemical binding]; other site 1206745001050 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206745001051 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1206745001052 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 1206745001053 TPP-binding site [chemical binding]; other site 1206745001054 putative dimer interface [polypeptide binding]; other site 1206745001055 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1206745001056 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1206745001057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206745001058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1206745001059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206745001060 DNA binding residues [nucleotide binding] 1206745001061 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1206745001062 16S/18S rRNA binding site [nucleotide binding]; other site 1206745001063 S13e-L30e interaction site [polypeptide binding]; other site 1206745001064 25S rRNA binding site [nucleotide binding]; other site 1206745001065 Predicted exporter [General function prediction only]; Region: COG4258 1206745001066 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1206745001067 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206745001068 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206745001069 dimer interface [polypeptide binding]; other site 1206745001070 ssDNA binding site [nucleotide binding]; other site 1206745001071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206745001072 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1206745001073 DNA polymerase III subunit delta; Validated; Region: PRK08487 1206745001074 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1206745001075 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1206745001076 RNB domain; Region: RNB; pfam00773 1206745001077 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1206745001078 active site 1206745001079 metal binding site [ion binding]; metal-binding site 1206745001080 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206745001081 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 1206745001082 active site 1206745001083 Zn binding site [ion binding]; other site 1206745001084 Bacterial SH3 domain; Region: SH3_3; pfam08239 1206745001085 Bacterial SH3 domain; Region: SH3_3; pfam08239 1206745001086 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1206745001087 dimer interface [polypeptide binding]; other site 1206745001088 motif 1; other site 1206745001089 active site 1206745001090 motif 2; other site 1206745001091 motif 3; other site 1206745001092 Protein of unknown function DUF89; Region: DUF89; cl15397 1206745001093 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 1206745001094 AIR carboxylase; Region: AIRC; smart01001 1206745001095 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1206745001096 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1206745001097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745001098 catalytic residue [active] 1206745001099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1206745001100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1206745001101 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1206745001102 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1206745001103 hinge; other site 1206745001104 active site 1206745001105 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1206745001106 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1206745001107 active site 1206745001108 tetramer interface; other site 1206745001109 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1206745001110 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206745001111 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206745001112 catalytic residue [active] 1206745001113 YGGT family; Region: YGGT; pfam02325 1206745001114 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 1206745001115 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206745001116 active site 1206745001117 HIGH motif; other site 1206745001118 nucleotide binding site [chemical binding]; other site 1206745001119 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206745001120 active site 1206745001121 KMSKS motif; other site 1206745001122 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206745001123 MarR family; Region: MarR_2; pfam12802 1206745001124 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1206745001125 putative homodimer interface [polypeptide binding]; other site 1206745001126 putative homotetramer interface [polypeptide binding]; other site 1206745001127 putative allosteric switch controlling residues; other site 1206745001128 putative metal binding site [ion binding]; other site 1206745001129 putative homodimer-homodimer interface [polypeptide binding]; other site 1206745001130 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1206745001131 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1206745001132 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1206745001133 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1206745001134 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1206745001135 active site 1206745001136 catalytic residues [active] 1206745001137 metal binding site [ion binding]; metal-binding site 1206745001138 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1206745001139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1206745001140 I-site; other site 1206745001141 active site 1206745001142 metal binding site [ion binding]; metal-binding site 1206745001143 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1206745001144 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1206745001145 oligomer interface [polypeptide binding]; other site 1206745001146 active site residues [active] 1206745001147 trigger factor; Provisional; Region: tig; PRK01490 1206745001148 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1206745001149 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1206745001150 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 1206745001151 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1206745001152 Walker A motif/ATP binding site; other site 1206745001153 Walker B motif; other site 1206745001154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745001155 dimer interface [polypeptide binding]; other site 1206745001156 putative CheW interface [polypeptide binding]; other site 1206745001157 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1206745001158 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206745001159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745001160 S-adenosylmethionine binding site [chemical binding]; other site 1206745001161 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1206745001162 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1206745001163 active site 1206745001164 HIGH motif; other site 1206745001165 KMSKS motif; other site 1206745001166 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1206745001167 tRNA binding surface [nucleotide binding]; other site 1206745001168 anticodon binding site; other site 1206745001169 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1206745001170 dimer interface [polypeptide binding]; other site 1206745001171 putative tRNA-binding site [nucleotide binding]; other site 1206745001172 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 1206745001173 active site 1206745001174 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1206745001175 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1206745001176 substrate binding site [chemical binding]; other site 1206745001177 hexamer interface [polypeptide binding]; other site 1206745001178 metal binding site [ion binding]; metal-binding site 1206745001179 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 1206745001180 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1206745001181 active site 1206745001182 catalytic site [active] 1206745001183 substrate binding site [chemical binding]; other site 1206745001184 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1206745001185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745001186 Peptidase family M48; Region: Peptidase_M48; pfam01435 1206745001187 CTP synthetase; Validated; Region: pyrG; PRK05380 1206745001188 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1206745001189 Catalytic site [active] 1206745001190 active site 1206745001191 UTP binding site [chemical binding]; other site 1206745001192 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1206745001193 active site 1206745001194 putative oxyanion hole; other site 1206745001195 catalytic triad [active] 1206745001196 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 1206745001197 DHH family; Region: DHH; pfam01368 1206745001198 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1206745001199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206745001200 substrate binding pocket [chemical binding]; other site 1206745001201 membrane-bound complex binding site; other site 1206745001202 hinge residues; other site 1206745001203 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1206745001204 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1206745001205 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 1206745001206 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1206745001207 dimer interface [polypeptide binding]; other site 1206745001208 active site 1206745001209 acyl carrier protein; Provisional; Region: acpP; PRK00982 1206745001210 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1206745001211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745001212 NAD(P) binding site [chemical binding]; other site 1206745001213 active site 1206745001214 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1206745001215 Transglycosylase; Region: Transgly; pfam00912 1206745001216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1206745001217 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1206745001218 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1206745001219 MG2 domain; Region: A2M_N; pfam01835 1206745001220 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1206745001221 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1206745001222 surface patch; other site 1206745001223 thioester region; other site 1206745001224 specificity defining residues; other site 1206745001225 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206745001226 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206745001227 active site 1206745001228 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1206745001229 putative acyl-acceptor binding pocket; other site 1206745001230 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206745001231 CoA binding domain; Region: CoA_binding; cl17356 1206745001232 PBP superfamily domain; Region: PBP_like_2; cl17296 1206745001233 PBP superfamily domain; Region: PBP_like_2; cl17296 1206745001234 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1206745001235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745001236 dimer interface [polypeptide binding]; other site 1206745001237 conserved gate region; other site 1206745001238 putative PBP binding loops; other site 1206745001239 ABC-ATPase subunit interface; other site 1206745001240 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1206745001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745001242 dimer interface [polypeptide binding]; other site 1206745001243 conserved gate region; other site 1206745001244 putative PBP binding loops; other site 1206745001245 ABC-ATPase subunit interface; other site 1206745001246 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1206745001247 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1206745001248 Walker A/P-loop; other site 1206745001249 ATP binding site [chemical binding]; other site 1206745001250 Q-loop/lid; other site 1206745001251 ABC transporter signature motif; other site 1206745001252 Walker B; other site 1206745001253 D-loop; other site 1206745001254 H-loop/switch region; other site 1206745001255 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206745001256 PhoU domain; Region: PhoU; pfam01895 1206745001257 PhoU domain; Region: PhoU; pfam01895 1206745001258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206745001259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745001260 active site 1206745001261 phosphorylation site [posttranslational modification] 1206745001262 intermolecular recognition site; other site 1206745001263 dimerization interface [polypeptide binding]; other site 1206745001264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206745001265 DNA binding site [nucleotide binding] 1206745001266 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1206745001267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206745001268 dimer interface [polypeptide binding]; other site 1206745001269 phosphorylation site [posttranslational modification] 1206745001270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745001271 ATP binding site [chemical binding]; other site 1206745001272 Mg2+ binding site [ion binding]; other site 1206745001273 G-X-G motif; other site 1206745001274 T5orf172 domain; Region: T5orf172; pfam10544 1206745001275 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1206745001276 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1206745001277 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1206745001278 trimerization site [polypeptide binding]; other site 1206745001279 active site 1206745001280 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1206745001281 NifU-like domain; Region: NifU; cl00484 1206745001282 R.HinP1I restriction endonuclease; Region: R-HINP1I; pfam11463 1206745001283 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1206745001284 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1206745001285 cofactor binding site; other site 1206745001286 DNA binding site [nucleotide binding] 1206745001287 substrate interaction site [chemical binding]; other site 1206745001288 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 1206745001289 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1206745001290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206745001291 catalytic residue [active] 1206745001292 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1206745001293 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1206745001294 transmembrane helices; other site 1206745001295 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1206745001296 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1206745001297 active site 1206745001298 catalytic triad [active] 1206745001299 dimer interface [polypeptide binding]; other site 1206745001300 adenylosuccinate lyase; Provisional; Region: PRK08470 1206745001301 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1206745001302 tetramer interface [polypeptide binding]; other site 1206745001303 active site 1206745001304 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1206745001305 Protein of unknown function (DUF511); Region: DUF511; cl01114 1206745001306 type II citrate synthase; Reviewed; Region: gltA; PRK05614 1206745001307 Citrate synthase; Region: Citrate_synt; pfam00285 1206745001308 oxalacetate binding site [chemical binding]; other site 1206745001309 citrylCoA binding site [chemical binding]; other site 1206745001310 coenzyme A binding site [chemical binding]; other site 1206745001311 catalytic triad [active] 1206745001312 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1206745001313 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1206745001314 5S rRNA interface [nucleotide binding]; other site 1206745001315 CTC domain interface [polypeptide binding]; other site 1206745001316 L16 interface [polypeptide binding]; other site 1206745001317 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1206745001318 putative active site [active] 1206745001319 catalytic residue [active] 1206745001320 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1206745001321 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1206745001322 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1206745001323 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1206745001324 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1206745001325 thiamine phosphate binding site [chemical binding]; other site 1206745001326 active site 1206745001327 pyrophosphate binding site [ion binding]; other site 1206745001328 Sulfatase; Region: Sulfatase; cl17466 1206745001329 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1206745001330 EamA-like transporter family; Region: EamA; pfam00892 1206745001331 TRL-like protein family; Region: TRL; pfam13146 1206745001332 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 1206745001333 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1206745001334 NodB motif; other site 1206745001335 putative active site [active] 1206745001336 putative catalytic site [active] 1206745001337 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1206745001338 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1206745001339 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1206745001340 Predicted permeases [General function prediction only]; Region: COG0679 1206745001341 antiporter inner membrane protein; Provisional; Region: PRK11670 1206745001342 Domain of unknown function DUF59; Region: DUF59; pfam01883 1206745001343 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1206745001344 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1206745001345 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1206745001346 active site 1206745001347 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206745001348 substrate binding site [chemical binding]; other site 1206745001349 catalytic residues [active] 1206745001350 dimer interface [polypeptide binding]; other site 1206745001351 Chorismate mutase type II; Region: CM_2; smart00830 1206745001352 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1206745001353 Prephenate dehydratase; Region: PDT; pfam00800 1206745001354 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1206745001355 putative L-Phe binding site [chemical binding]; other site 1206745001356 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1206745001357 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1206745001358 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1206745001359 active site 1206745001360 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1206745001361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206745001362 PGAP1-like protein; Region: PGAP1; pfam07819 1206745001363 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206745001364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206745001365 active site 1206745001366 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1206745001367 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1206745001368 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1206745001369 active site 1206745001370 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1206745001371 alanine racemase; Reviewed; Region: alr; PRK00053 1206745001372 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206745001373 catalytic residue [active] 1206745001374 Cytochrome c; Region: Cytochrom_C; cl11414 1206745001375 recombination protein RecR; Reviewed; Region: recR; PRK00076 1206745001376 RecR protein; Region: RecR; pfam02132 1206745001377 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1206745001378 putative active site [active] 1206745001379 putative metal-binding site [ion binding]; other site 1206745001380 tetramer interface [polypeptide binding]; other site 1206745001381 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1206745001382 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206745001383 HSP70 interaction site [polypeptide binding]; other site 1206745001384 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1206745001385 Zn binding sites [ion binding]; other site 1206745001386 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1206745001387 dimer interface [polypeptide binding]; other site 1206745001388 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1206745001389 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1206745001390 dimer interface [polypeptide binding]; other site 1206745001391 active site 1206745001392 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1206745001393 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1206745001394 putative ribose interaction site [chemical binding]; other site 1206745001395 putative ADP binding site [chemical binding]; other site 1206745001396 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1206745001397 active site 1206745001398 HIGH motif; other site 1206745001399 nucleotide binding site [chemical binding]; other site 1206745001400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745001401 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1206745001402 NAD(P) binding site [chemical binding]; other site 1206745001403 active site 1206745001404 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 1206745001405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206745001406 active site 1206745001407 motif I; other site 1206745001408 motif II; other site 1206745001409 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 1206745001410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1206745001411 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1206745001412 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1206745001413 dimer interface [polypeptide binding]; other site 1206745001414 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1206745001415 catalytic triad [active] 1206745001416 peroxidatic and resolving cysteines [active] 1206745001417 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1206745001418 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1206745001419 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1206745001420 Na binding site [ion binding]; other site 1206745001421 glycoprotein BALF4; Provisional; Region: PHA03231 1206745001422 excinuclease ABC subunit B; Provisional; Region: PRK05298 1206745001423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745001424 ATP binding site [chemical binding]; other site 1206745001425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745001426 nucleotide binding region [chemical binding]; other site 1206745001427 ATP-binding site [chemical binding]; other site 1206745001428 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1206745001429 UvrB/uvrC motif; Region: UVR; pfam02151 1206745001430 primosome assembly protein PriA; Validated; Region: PRK05580 1206745001431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745001432 ATP binding site [chemical binding]; other site 1206745001433 putative Mg++ binding site [ion binding]; other site 1206745001434 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1206745001435 ATP-binding site [chemical binding]; other site 1206745001436 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1206745001437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745001438 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1206745001439 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1206745001440 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1206745001441 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1206745001442 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1206745001443 active site 1206745001444 (T/H)XGH motif; other site 1206745001445 nickel responsive regulator; Provisional; Region: PRK00630 1206745001446 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206745001447 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1206745001448 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 1206745001449 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1206745001450 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1206745001451 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1206745001452 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1206745001453 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206745001454 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206745001455 Walker A/P-loop; other site 1206745001456 ATP binding site [chemical binding]; other site 1206745001457 Q-loop/lid; other site 1206745001458 ABC transporter signature motif; other site 1206745001459 Walker B; other site 1206745001460 D-loop; other site 1206745001461 H-loop/switch region; other site 1206745001462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745001463 dimer interface [polypeptide binding]; other site 1206745001464 conserved gate region; other site 1206745001465 putative PBP binding loops; other site 1206745001466 ABC-ATPase subunit interface; other site 1206745001467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745001468 dimer interface [polypeptide binding]; other site 1206745001469 conserved gate region; other site 1206745001470 putative PBP binding loops; other site 1206745001471 ABC-ATPase subunit interface; other site 1206745001472 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1206745001473 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1206745001474 AAA ATPase domain; Region: AAA_15; pfam13175 1206745001475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745001476 Walker B; other site 1206745001477 D-loop; other site 1206745001478 H-loop/switch region; other site 1206745001479 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1206745001480 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1206745001481 putative active site; other site 1206745001482 catalytic triad [active] 1206745001483 putative dimer interface [polypeptide binding]; other site 1206745001484 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1206745001485 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1206745001486 ATP binding site [chemical binding]; other site 1206745001487 substrate interface [chemical binding]; other site 1206745001488 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1206745001489 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206745001490 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206745001491 substrate binding pocket [chemical binding]; other site 1206745001492 chain length determination region; other site 1206745001493 substrate-Mg2+ binding site; other site 1206745001494 catalytic residues [active] 1206745001495 aspartate-rich region 1; other site 1206745001496 active site lid residues [active] 1206745001497 aspartate-rich region 2; other site 1206745001498 PDZ domain; Region: PDZ_2; pfam13180 1206745001499 hypothetical protein; Provisional; Region: PRK03762 1206745001500 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1206745001501 tetramerization interface [polypeptide binding]; other site 1206745001502 active site 1206745001503 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1206745001504 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1206745001505 dinuclear metal binding motif [ion binding]; other site 1206745001506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206745001507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745001508 putative substrate translocation pore; other site 1206745001509 Phosphoglycerate kinase; Region: PGK; pfam00162 1206745001510 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1206745001511 substrate binding site [chemical binding]; other site 1206745001512 hinge regions; other site 1206745001513 ADP binding site [chemical binding]; other site 1206745001514 catalytic site [active] 1206745001515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745001516 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745001517 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1206745001518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745001519 active site 1206745001520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745001521 Acylphosphatase; Region: Acylphosphatase; pfam00708 1206745001522 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1206745001523 HypF finger; Region: zf-HYPF; pfam07503 1206745001524 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1206745001525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206745001526 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 1206745001527 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1206745001528 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1206745001529 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1206745001530 AAA domain; Region: AAA_11; pfam13086 1206745001531 Part of AAA domain; Region: AAA_19; pfam13245 1206745001532 AAA domain; Region: AAA_12; pfam13087 1206745001533 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1206745001534 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1206745001535 dimerization interface [polypeptide binding]; other site 1206745001536 ATP binding site [chemical binding]; other site 1206745001537 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1206745001538 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1206745001539 FtsX-like permease family; Region: FtsX; pfam02687 1206745001540 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1206745001541 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1206745001542 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1206745001543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745001544 nucleotide binding region [chemical binding]; other site 1206745001545 ATP-binding site [chemical binding]; other site 1206745001546 SEC-C motif; Region: SEC-C; pfam02810 1206745001547 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1206745001548 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1206745001549 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1206745001550 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1206745001551 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206745001552 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 1206745001553 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1206745001554 glutamine binding [chemical binding]; other site 1206745001555 catalytic triad [active] 1206745001556 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1206745001557 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1206745001558 Protein of unknown function DUF45; Region: DUF45; pfam01863 1206745001559 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1206745001560 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1206745001561 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1206745001562 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1206745001563 active site 1206745001564 HslU subunit interaction site [polypeptide binding]; other site 1206745001565 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1206745001566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001567 Walker A motif; other site 1206745001568 ATP binding site [chemical binding]; other site 1206745001569 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1206745001570 Walker B motif; other site 1206745001571 arginine finger; other site 1206745001572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1206745001573 GTPase Era; Reviewed; Region: era; PRK00089 1206745001574 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1206745001575 G1 box; other site 1206745001576 GTP/Mg2+ binding site [chemical binding]; other site 1206745001577 Switch I region; other site 1206745001578 G2 box; other site 1206745001579 Switch II region; other site 1206745001580 G3 box; other site 1206745001581 G4 box; other site 1206745001582 G5 box; other site 1206745001583 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1206745001584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1206745001585 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 1206745001586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745001587 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1206745001588 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206745001589 putative acyl-acceptor binding pocket; other site 1206745001590 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1206745001591 acyl-activating enzyme (AAE) consensus motif; other site 1206745001592 putative AMP binding site [chemical binding]; other site 1206745001593 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1206745001594 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1206745001595 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1206745001596 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1206745001597 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1206745001598 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1206745001599 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1206745001600 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1206745001601 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1206745001602 putative translocon binding site; other site 1206745001603 protein-rRNA interface [nucleotide binding]; other site 1206745001604 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1206745001605 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1206745001606 G-X-X-G motif; other site 1206745001607 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1206745001608 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1206745001609 23S rRNA interface [nucleotide binding]; other site 1206745001610 5S rRNA interface [nucleotide binding]; other site 1206745001611 putative antibiotic binding site [chemical binding]; other site 1206745001612 L25 interface [polypeptide binding]; other site 1206745001613 L27 interface [polypeptide binding]; other site 1206745001614 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1206745001615 23S rRNA interface [nucleotide binding]; other site 1206745001616 putative translocon interaction site; other site 1206745001617 signal recognition particle (SRP54) interaction site; other site 1206745001618 L23 interface [polypeptide binding]; other site 1206745001619 trigger factor interaction site; other site 1206745001620 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1206745001621 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1206745001622 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1206745001623 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1206745001624 RNA binding site [nucleotide binding]; other site 1206745001625 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1206745001626 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1206745001627 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1206745001628 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1206745001629 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1206745001630 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1206745001631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206745001632 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206745001633 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1206745001634 23S rRNA interface [nucleotide binding]; other site 1206745001635 5S rRNA interface [nucleotide binding]; other site 1206745001636 L27 interface [polypeptide binding]; other site 1206745001637 L5 interface [polypeptide binding]; other site 1206745001638 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1206745001639 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1206745001640 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1206745001641 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1206745001642 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1206745001643 SecY translocase; Region: SecY; pfam00344 1206745001644 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1206745001645 active site 1206745001646 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1206745001647 rRNA binding site [nucleotide binding]; other site 1206745001648 predicted 30S ribosome binding site; other site 1206745001649 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1206745001650 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1206745001651 30S ribosomal protein S11; Validated; Region: PRK05309 1206745001652 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1206745001653 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1206745001654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206745001655 RNA binding surface [nucleotide binding]; other site 1206745001656 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1206745001657 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1206745001658 alphaNTD homodimer interface [polypeptide binding]; other site 1206745001659 alphaNTD - beta interaction site [polypeptide binding]; other site 1206745001660 alphaNTD - beta' interaction site [polypeptide binding]; other site 1206745001661 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1206745001662 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1206745001663 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1206745001664 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1206745001665 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1206745001666 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1206745001667 substrate-cofactor binding pocket; other site 1206745001668 homodimer interface [polypeptide binding]; other site 1206745001669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745001670 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1206745001671 catalytic residue [active] 1206745001672 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1206745001673 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1206745001674 glutamine binding [chemical binding]; other site 1206745001675 catalytic triad [active] 1206745001676 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1206745001677 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1206745001678 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206745001679 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1206745001680 molybdopterin cofactor binding site; other site 1206745001681 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1206745001682 molybdopterin cofactor binding site; other site 1206745001683 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1206745001684 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1206745001685 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1206745001686 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1206745001687 Outer membrane efflux protein; Region: OEP; pfam02321 1206745001688 Outer membrane efflux protein; Region: OEP; pfam02321 1206745001689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1206745001690 HlyD family secretion protein; Region: HlyD_3; pfam13437 1206745001691 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1206745001692 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1206745001693 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1206745001694 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1206745001695 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1206745001696 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1206745001697 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1206745001698 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1206745001699 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745001700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745001701 S-adenosylmethionine binding site [chemical binding]; other site 1206745001702 O-methyltransferase; Region: Methyltransf_2; pfam00891 1206745001703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745001704 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1206745001705 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1206745001706 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1206745001707 putative active site [active] 1206745001708 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1206745001709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1206745001710 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745001712 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745001713 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1206745001714 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1206745001715 putative active site [active] 1206745001716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745001717 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1206745001718 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745001719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745001720 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1206745001721 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1206745001722 dimerization interface [polypeptide binding]; other site 1206745001723 DPS ferroxidase diiron center [ion binding]; other site 1206745001724 ion pore; other site 1206745001725 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 1206745001726 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1206745001727 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1206745001728 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1206745001729 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1206745001730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206745001731 active site 1206745001732 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1206745001733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206745001734 UDP-galactopyranose mutase; Region: GLF; pfam03275 1206745001735 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1206745001736 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1206745001737 ATP binding site [chemical binding]; other site 1206745001738 substrate interface [chemical binding]; other site 1206745001739 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1206745001740 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1206745001741 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206745001742 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1206745001743 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206745001744 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1206745001745 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1206745001746 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206745001747 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1206745001748 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1206745001749 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1206745001750 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1206745001751 4Fe-4S binding domain; Region: Fer4; pfam00037 1206745001752 4Fe-4S binding domain; Region: Fer4; pfam00037 1206745001753 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1206745001754 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1206745001755 NADH dehydrogenase subunit G; Validated; Region: PRK08493 1206745001756 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206745001757 catalytic loop [active] 1206745001758 iron binding site [ion binding]; other site 1206745001759 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1206745001760 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206745001761 NADH dehydrogenase subunit G; Validated; Region: PRK08493 1206745001762 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1206745001763 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1206745001764 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1206745001765 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1206745001766 NADH dehydrogenase subunit A; Validated; Region: PRK08489 1206745001767 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1206745001768 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1206745001769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206745001770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1206745001771 dimer interface [polypeptide binding]; other site 1206745001772 phosphorylation site [posttranslational modification] 1206745001773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745001774 ATP binding site [chemical binding]; other site 1206745001775 Mg2+ binding site [ion binding]; other site 1206745001776 G-X-G motif; other site 1206745001777 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1206745001778 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1206745001779 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1206745001780 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1206745001781 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1206745001782 hinge; other site 1206745001783 active site 1206745001784 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1206745001785 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1206745001786 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1206745001787 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206745001788 RNA binding site [nucleotide binding]; other site 1206745001789 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1206745001790 RNA binding site [nucleotide binding]; other site 1206745001791 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1206745001792 RNA binding site [nucleotide binding]; other site 1206745001793 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206745001794 RNA binding site [nucleotide binding]; other site 1206745001795 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206745001796 RNA binding site [nucleotide binding]; other site 1206745001797 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1206745001798 RNA binding site [nucleotide binding]; other site 1206745001799 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1206745001800 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1206745001801 ligand binding site [chemical binding]; other site 1206745001802 NAD binding site [chemical binding]; other site 1206745001803 dimerization interface [polypeptide binding]; other site 1206745001804 catalytic site [active] 1206745001805 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1206745001806 putative L-serine binding site [chemical binding]; other site 1206745001807 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1206745001808 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206745001809 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206745001810 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1206745001811 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1206745001812 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1206745001813 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745001814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206745001815 Acylphosphatase; Region: Acylphosphatase; pfam00708 1206745001816 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1206745001817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206745001818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206745001819 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1206745001820 nucleotide binding site/active site [active] 1206745001821 HIT family signature motif; other site 1206745001822 catalytic residue [active] 1206745001823 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1206745001824 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1206745001825 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1206745001826 DNA gyrase subunit A; Validated; Region: PRK05560 1206745001827 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1206745001828 CAP-like domain; other site 1206745001829 active site 1206745001830 primary dimer interface [polypeptide binding]; other site 1206745001831 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001833 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001834 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001835 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001836 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206745001837 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1206745001838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745001839 active site 1206745001840 phosphorylation site [posttranslational modification] 1206745001841 intermolecular recognition site; other site 1206745001842 dimerization interface [polypeptide binding]; other site 1206745001843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001844 Walker A motif; other site 1206745001845 ATP binding site [chemical binding]; other site 1206745001846 Walker B motif; other site 1206745001847 arginine finger; other site 1206745001848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1206745001849 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 1206745001850 recombination factor protein RarA; Reviewed; Region: PRK13342 1206745001851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001852 Walker A motif; other site 1206745001853 ATP binding site [chemical binding]; other site 1206745001854 Walker B motif; other site 1206745001855 arginine finger; other site 1206745001856 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1206745001857 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1206745001858 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206745001859 DNA binding residues [nucleotide binding] 1206745001860 putative dimer interface [polypeptide binding]; other site 1206745001861 chaperone protein DnaJ; Provisional; Region: PRK14299 1206745001862 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206745001863 HSP70 interaction site [polypeptide binding]; other site 1206745001864 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1206745001865 substrate binding site [polypeptide binding]; other site 1206745001866 dimer interface [polypeptide binding]; other site 1206745001867 putative recombination protein RecB; Provisional; Region: PRK13909 1206745001868 Family description; Region: UvrD_C_2; pfam13538 1206745001869 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1206745001870 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1206745001871 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856 1206745001872 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1206745001873 protein-export membrane protein SecD; Region: secD; TIGR01129 1206745001874 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1206745001875 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1206745001876 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1206745001877 Protein export membrane protein; Region: SecD_SecF; cl14618 1206745001878 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1206745001879 flagellin A; Reviewed; Region: PRK12584 1206745001880 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1206745001881 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1206745001882 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1206745001883 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1206745001884 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 1206745001885 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1206745001886 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1206745001887 homodimer interface [polypeptide binding]; other site 1206745001888 NADP binding site [chemical binding]; other site 1206745001889 substrate binding site [chemical binding]; other site 1206745001890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206745001891 Catalytic site [active] 1206745001892 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206745001893 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1206745001894 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1206745001895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745001896 active site 1206745001897 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1206745001898 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206745001899 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1206745001900 Substrate-binding/catalytic site; other site 1206745001901 Zn-binding sites [ion binding]; other site 1206745001902 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1206745001903 interface (dimer of trimers) [polypeptide binding]; other site 1206745001904 Substrate-binding/catalytic site; other site 1206745001905 GTP-binding protein YchF; Reviewed; Region: PRK09601 1206745001906 YchF GTPase; Region: YchF; cd01900 1206745001907 G1 box; other site 1206745001908 GTP/Mg2+ binding site [chemical binding]; other site 1206745001909 Switch I region; other site 1206745001910 G2 box; other site 1206745001911 Switch II region; other site 1206745001912 G3 box; other site 1206745001913 G4 box; other site 1206745001914 G5 box; other site 1206745001915 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1206745001916 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1206745001917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001918 Walker B motif; other site 1206745001919 arginine finger; other site 1206745001920 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1206745001921 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 1206745001922 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1206745001923 Clp amino terminal domain; Region: Clp_N; pfam02861 1206745001924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001925 Walker A motif; other site 1206745001926 ATP binding site [chemical binding]; other site 1206745001927 Walker B motif; other site 1206745001928 arginine finger; other site 1206745001929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745001930 Walker A motif; other site 1206745001931 ATP binding site [chemical binding]; other site 1206745001932 Walker B motif; other site 1206745001933 arginine finger; other site 1206745001934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206745001935 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 1206745001936 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 1206745001937 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 1206745001938 putative catalytic site [active] 1206745001939 CdtC interface [polypeptide binding]; other site 1206745001940 heterotrimer interface [polypeptide binding]; other site 1206745001941 CdtA interface [polypeptide binding]; other site 1206745001942 putative metal binding site [ion binding]; other site 1206745001943 putative phosphate binding site [ion binding]; other site 1206745001944 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 1206745001945 elongation factor P; Validated; Region: PRK00529 1206745001946 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1206745001947 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1206745001948 RNA binding site [nucleotide binding]; other site 1206745001949 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1206745001950 RNA binding site [nucleotide binding]; other site 1206745001951 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1206745001952 intersubunit interface [polypeptide binding]; other site 1206745001953 active site 1206745001954 zinc binding site [ion binding]; other site 1206745001955 Na+ binding site [ion binding]; other site 1206745001956 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 1206745001957 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1206745001958 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1206745001959 active site 1206745001960 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1206745001961 cell division protein FtsW; Region: ftsW; TIGR02614 1206745001962 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745001963 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745001964 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1206745001965 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1206745001966 Ligand Binding Site [chemical binding]; other site 1206745001967 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1206745001968 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206745001969 putative trimer interface [polypeptide binding]; other site 1206745001970 putative CoA binding site [chemical binding]; other site 1206745001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745001972 S-adenosylmethionine binding site [chemical binding]; other site 1206745001973 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745001974 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 1206745001975 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1206745001976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206745001977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206745001978 catalytic residue [active] 1206745001979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745001980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745001981 S-adenosylmethionine binding site [chemical binding]; other site 1206745001982 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745001983 ligand binding site; other site 1206745001984 tetramer interface; other site 1206745001985 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745001986 ligand binding site; other site 1206745001987 tetramer interface; other site 1206745001988 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745001989 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745001990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745001991 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1206745001992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745001993 NAD(P) binding site [chemical binding]; other site 1206745001994 active site 1206745001995 classical (c) SDRs; Region: SDR_c; cd05233 1206745001996 NAD(P) binding site [chemical binding]; other site 1206745001997 active site 1206745001998 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745001999 ligand binding site; other site 1206745002000 tetramer interface; other site 1206745002001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745002002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745002003 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1206745002004 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745002005 ligand binding site; other site 1206745002006 tetramer interface; other site 1206745002007 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745002008 ligand binding site; other site 1206745002009 tetramer interface; other site 1206745002010 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745002011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002012 S-adenosylmethionine binding site [chemical binding]; other site 1206745002013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745002014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 1206745002015 FOG: CBS domain [General function prediction only]; Region: COG0517 1206745002016 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 1206745002017 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1206745002018 Substrate binding site; other site 1206745002019 metal-binding site 1206745002020 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1206745002021 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206745002022 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745002023 inhibitor-cofactor binding pocket; inhibition site 1206745002024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002025 catalytic residue [active] 1206745002026 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745002027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002028 S-adenosylmethionine binding site [chemical binding]; other site 1206745002029 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1206745002030 AP (apurinic/apyrimidinic) site pocket; other site 1206745002031 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1206745002032 DNA interaction; other site 1206745002033 Metal-binding active site; metal-binding site 1206745002034 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1206745002035 Ligand Binding Site [chemical binding]; other site 1206745002036 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745002037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002038 S-adenosylmethionine binding site [chemical binding]; other site 1206745002039 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1206745002040 GTP-binding protein LepA; Provisional; Region: PRK05433 1206745002041 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1206745002042 G1 box; other site 1206745002043 putative GEF interaction site [polypeptide binding]; other site 1206745002044 GTP/Mg2+ binding site [chemical binding]; other site 1206745002045 Switch I region; other site 1206745002046 G2 box; other site 1206745002047 G3 box; other site 1206745002048 Switch II region; other site 1206745002049 G4 box; other site 1206745002050 G5 box; other site 1206745002051 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1206745002052 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1206745002053 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1206745002054 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1206745002055 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745002056 inhibitor-cofactor binding pocket; inhibition site 1206745002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002058 catalytic residue [active] 1206745002059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745002060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745002061 dimer interface [polypeptide binding]; other site 1206745002062 putative CheW interface [polypeptide binding]; other site 1206745002063 DinB family; Region: DinB; cl17821 1206745002064 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206745002065 active site 1206745002066 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745002067 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745002068 DNA methylase; Region: N6_N4_Mtase; cl17433 1206745002069 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1206745002070 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1206745002071 cofactor binding site; other site 1206745002072 DNA binding site [nucleotide binding] 1206745002073 substrate interaction site [chemical binding]; other site 1206745002074 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206745002075 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206745002076 dimer interface [polypeptide binding]; other site 1206745002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002078 catalytic residue [active] 1206745002079 DpnII restriction endonuclease; Region: DpnII; pfam04556 1206745002080 DpnII restriction endonuclease; Region: DpnII; pfam04556 1206745002081 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745002082 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745002083 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745002084 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745002085 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745002086 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1206745002087 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206745002088 homodimer interface [polypeptide binding]; other site 1206745002089 substrate-cofactor binding pocket; other site 1206745002090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002091 catalytic residue [active] 1206745002092 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1206745002093 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1206745002094 putative substrate-binding site; other site 1206745002095 nickel binding site [ion binding]; other site 1206745002096 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 1206745002097 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1206745002098 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1206745002099 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1206745002100 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1206745002101 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206745002102 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206745002103 catalytic residues [active] 1206745002104 putative metal dependent hydrolase; Provisional; Region: PRK11598 1206745002105 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1206745002106 Sulfatase; Region: Sulfatase; pfam00884 1206745002107 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1206745002108 hypothetical protein; Provisional; Region: PRK04081 1206745002109 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1206745002110 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1206745002111 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1206745002112 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1206745002113 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206745002114 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206745002115 ligand binding site [chemical binding]; other site 1206745002116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206745002117 non-specific DNA interactions [nucleotide binding]; other site 1206745002118 DNA binding site [nucleotide binding] 1206745002119 sequence specific DNA binding site [nucleotide binding]; other site 1206745002120 putative cAMP binding site [chemical binding]; other site 1206745002121 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1206745002122 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1206745002123 active site 1206745002124 homodimer interface [polypeptide binding]; other site 1206745002125 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1206745002126 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1206745002127 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1206745002128 active site 1206745002129 homodimer interface [polypeptide binding]; other site 1206745002130 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1206745002131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206745002132 motif II; other site 1206745002133 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1206745002134 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002135 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206745002136 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745002137 inhibitor-cofactor binding pocket; inhibition site 1206745002138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002139 catalytic residue [active] 1206745002140 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206745002141 extended (e) SDRs; Region: SDR_e; cd08946 1206745002142 NAD(P) binding site [chemical binding]; other site 1206745002143 substrate binding site [chemical binding]; other site 1206745002144 active site 1206745002145 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002146 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1206745002147 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002149 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206745002150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745002151 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1206745002152 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 1206745002153 putative active site [active] 1206745002154 putative substrate binding site [chemical binding]; other site 1206745002155 putative cosubstrate binding site; other site 1206745002156 catalytic site [active] 1206745002157 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1206745002158 active site 1206745002159 hexamer interface [polypeptide binding]; other site 1206745002160 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1206745002161 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1206745002162 active site 1206745002163 homodimer interface [polypeptide binding]; other site 1206745002164 HdeA/HdeB family; Region: HdeA; cl05752 1206745002165 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1206745002166 NeuB family; Region: NeuB; pfam03102 1206745002167 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1206745002168 NeuB binding interface [polypeptide binding]; other site 1206745002169 putative substrate binding site [chemical binding]; other site 1206745002170 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1206745002171 dimer interface [polypeptide binding]; other site 1206745002172 FMN binding site [chemical binding]; other site 1206745002173 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206745002174 putative trimer interface [polypeptide binding]; other site 1206745002175 putative CoA binding site [chemical binding]; other site 1206745002176 classical (c) SDRs; Region: SDR_c; cd05233 1206745002177 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1206745002178 NAD(P) binding site [chemical binding]; other site 1206745002179 active site 1206745002180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206745002181 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1206745002182 active site 1206745002183 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1206745002184 active site 1206745002185 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1206745002186 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1206745002187 trimer interface [polypeptide binding]; other site 1206745002188 active site 1206745002189 substrate binding site [chemical binding]; other site 1206745002190 CoA binding site [chemical binding]; other site 1206745002191 AMP-binding enzyme; Region: AMP-binding; pfam00501 1206745002192 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002194 acyl-activating enzyme (AAE) consensus motif; other site 1206745002195 acyl-activating enzyme (AAE) consensus motif; other site 1206745002196 active site 1206745002197 AMP binding site [chemical binding]; other site 1206745002198 CoA binding site [chemical binding]; other site 1206745002199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002200 CoA binding site [chemical binding]; other site 1206745002201 AMP-binding enzyme; Region: AMP-binding; pfam00501 1206745002202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002204 acyl-activating enzyme (AAE) consensus motif; other site 1206745002205 acyl-activating enzyme (AAE) consensus motif; other site 1206745002206 active site 1206745002207 AMP binding site [chemical binding]; other site 1206745002208 CoA binding site [chemical binding]; other site 1206745002209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206745002210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745002211 NAD(P) binding site [chemical binding]; other site 1206745002212 classical (c) SDRs; Region: SDR_c; cd05233 1206745002213 active site 1206745002214 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1206745002215 active site 1206745002216 substrate binding site [chemical binding]; other site 1206745002217 cosubstrate binding site; other site 1206745002218 catalytic site [active] 1206745002219 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1206745002220 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1206745002221 active site 1206745002222 cosubstrate binding site; other site 1206745002223 substrate binding site [chemical binding]; other site 1206745002224 catalytic site [active] 1206745002225 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1206745002226 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1206745002227 trimer interface [polypeptide binding]; other site 1206745002228 active site 1206745002229 substrate binding site [chemical binding]; other site 1206745002230 CoA binding site [chemical binding]; other site 1206745002231 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1206745002232 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1206745002233 putative trimer interface [polypeptide binding]; other site 1206745002234 putative CoA binding site [chemical binding]; other site 1206745002235 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1206745002236 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745002237 inhibitor-cofactor binding pocket; inhibition site 1206745002238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002239 catalytic residue [active] 1206745002240 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1206745002241 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1206745002242 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1206745002243 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 1206745002244 NAD binding site [chemical binding]; other site 1206745002245 substrate binding site [chemical binding]; other site 1206745002246 active site 1206745002247 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206745002248 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745002249 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1206745002250 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1206745002251 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745002252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1206745002253 active site 1206745002254 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1206745002255 GTP1/OBG; Region: GTP1_OBG; pfam01018 1206745002256 Obg GTPase; Region: Obg; cd01898 1206745002257 G1 box; other site 1206745002258 GTP/Mg2+ binding site [chemical binding]; other site 1206745002259 Switch I region; other site 1206745002260 G2 box; other site 1206745002261 G3 box; other site 1206745002262 Switch II region; other site 1206745002263 G4 box; other site 1206745002264 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1206745002265 trimer interface [polypeptide binding]; other site 1206745002266 active site 1206745002267 substrate binding site [chemical binding]; other site 1206745002268 CoA binding site [chemical binding]; other site 1206745002269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206745002270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206745002271 Walker A/P-loop; other site 1206745002272 ATP binding site [chemical binding]; other site 1206745002273 Q-loop/lid; other site 1206745002274 ABC transporter signature motif; other site 1206745002275 Walker B; other site 1206745002276 D-loop; other site 1206745002277 H-loop/switch region; other site 1206745002278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745002279 dimer interface [polypeptide binding]; other site 1206745002280 conserved gate region; other site 1206745002281 putative PBP binding loops; other site 1206745002282 ABC-ATPase subunit interface; other site 1206745002283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206745002284 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206745002285 substrate binding pocket [chemical binding]; other site 1206745002286 membrane-bound complex binding site; other site 1206745002287 hinge residues; other site 1206745002288 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1206745002289 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206745002290 active site 1206745002291 Hemerythrin; Region: Hemerythrin; cd12107 1206745002292 Fe binding site [ion binding]; other site 1206745002293 Hemerythrin; Region: Hemerythrin; cd12107 1206745002294 Fe binding site [ion binding]; other site 1206745002295 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1206745002296 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1206745002297 putative active site [active] 1206745002298 putative metal binding site [ion binding]; other site 1206745002299 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1206745002300 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1206745002301 active site 1206745002302 ribulose/triose binding site [chemical binding]; other site 1206745002303 phosphate binding site [ion binding]; other site 1206745002304 substrate (anthranilate) binding pocket [chemical binding]; other site 1206745002305 product (indole) binding pocket [chemical binding]; other site 1206745002306 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1206745002307 active site 1206745002308 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1206745002309 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1206745002310 Carbon starvation protein CstA; Region: CstA; pfam02554 1206745002311 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1206745002312 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1206745002313 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1206745002314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745002315 dimer interface [polypeptide binding]; other site 1206745002316 conserved gate region; other site 1206745002317 putative PBP binding loops; other site 1206745002318 ABC-ATPase subunit interface; other site 1206745002319 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1206745002320 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1206745002321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745002322 putative PBP binding loops; other site 1206745002323 dimer interface [polypeptide binding]; other site 1206745002324 ABC-ATPase subunit interface; other site 1206745002325 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1206745002326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206745002327 Walker A/P-loop; other site 1206745002328 ATP binding site [chemical binding]; other site 1206745002329 Q-loop/lid; other site 1206745002330 ABC transporter signature motif; other site 1206745002331 Walker B; other site 1206745002332 D-loop; other site 1206745002333 H-loop/switch region; other site 1206745002334 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206745002335 Walker A/P-loop; other site 1206745002336 ATP binding site [chemical binding]; other site 1206745002337 Q-loop/lid; other site 1206745002338 ABC transporter signature motif; other site 1206745002339 Walker B; other site 1206745002340 D-loop; other site 1206745002341 H-loop/switch region; other site 1206745002342 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 1206745002343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206745002344 minor groove reading motif; other site 1206745002345 helix-hairpin-helix signature motif; other site 1206745002346 active site 1206745002347 fumarate hydratase; Provisional; Region: PRK06246 1206745002348 Fumarase C-terminus; Region: Fumerase_C; cl00795 1206745002349 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1206745002350 generic binding surface I; other site 1206745002351 generic binding surface II; other site 1206745002352 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1206745002353 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1206745002354 heme binding pocket [chemical binding]; other site 1206745002355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1206745002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1206745002357 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1206745002358 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1206745002359 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1206745002360 oligomer interface [polypeptide binding]; other site 1206745002361 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1206745002362 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1206745002363 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1206745002364 active site 1206745002365 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1206745002366 protein binding site [polypeptide binding]; other site 1206745002367 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1206745002368 putative substrate binding region [chemical binding]; other site 1206745002369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1206745002370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206745002371 catalytic residue [active] 1206745002372 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1206745002373 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1206745002374 Protein of unknown function (DUF328); Region: DUF328; cl01143 1206745002375 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1206745002376 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1206745002377 active site 1206745002378 catalytic residues [active] 1206745002379 metal binding site [ion binding]; metal-binding site 1206745002380 homodimer binding site [polypeptide binding]; other site 1206745002381 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206745002382 carboxyltransferase (CT) interaction site; other site 1206745002383 biotinylation site [posttranslational modification]; other site 1206745002384 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1206745002385 homotrimer interaction site [polypeptide binding]; other site 1206745002386 putative active site [active] 1206745002387 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1206745002388 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1206745002389 oligomer interface [polypeptide binding]; other site 1206745002390 tandem repeat interface [polypeptide binding]; other site 1206745002391 active site residues [active] 1206745002392 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1206745002393 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1206745002394 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1206745002395 active site 1206745002396 substrate binding site [chemical binding]; other site 1206745002397 cosubstrate binding site; other site 1206745002398 catalytic site [active] 1206745002399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206745002400 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1206745002401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002402 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1206745002403 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1206745002404 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206745002405 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1206745002406 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002407 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1206745002408 IMP binding site; other site 1206745002409 dimer interface [polypeptide binding]; other site 1206745002410 interdomain contacts; other site 1206745002411 partial ornithine binding site; other site 1206745002412 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 1206745002413 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1206745002414 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1206745002415 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1206745002416 putative active site [active] 1206745002417 putative metal binding site [ion binding]; other site 1206745002418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206745002419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745002420 active site 1206745002421 phosphorylation site [posttranslational modification] 1206745002422 intermolecular recognition site; other site 1206745002423 dimerization interface [polypeptide binding]; other site 1206745002424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206745002425 DNA binding site [nucleotide binding] 1206745002426 spermidine synthase; Provisional; Region: speE; PRK00536 1206745002427 spermidine synthase; Provisional; Region: PRK00811 1206745002428 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1206745002429 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1206745002430 CoA-binding site [chemical binding]; other site 1206745002431 ATP-binding [chemical binding]; other site 1206745002432 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1206745002433 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206745002434 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206745002435 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1206745002436 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206745002437 RNA binding surface [nucleotide binding]; other site 1206745002438 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1206745002439 flagellar hook protein FlgE, epsilon proteobacterial; Region: flgE_epsilon; TIGR02489 1206745002440 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1206745002441 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1206745002442 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1206745002443 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745002444 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 1206745002445 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1206745002446 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 1206745002447 Sulfatase; Region: Sulfatase; cl17466 1206745002448 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206745002449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002450 S-adenosylmethionine binding site [chemical binding]; other site 1206745002451 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1206745002452 active site 1206745002453 hypothetical protein; Provisional; Region: PRK05849 1206745002454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1206745002455 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206745002456 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1206745002457 conserved cys residue [active] 1206745002458 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1206745002459 active site 1206745002460 substrate binding site [chemical binding]; other site 1206745002461 cosubstrate binding site; other site 1206745002462 catalytic site [active] 1206745002463 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1206745002464 active site 1206745002465 metal-binding site 1206745002466 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206745002467 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1206745002468 active site 1206745002469 nucleotide binding site [chemical binding]; other site 1206745002470 HIGH motif; other site 1206745002471 KMSKS motif; other site 1206745002472 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1206745002473 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1206745002474 tetramer interface [polypeptide binding]; other site 1206745002475 active site 1206745002476 Mg2+/Mn2+ binding site [ion binding]; other site 1206745002477 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206745002478 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1206745002479 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1206745002480 PYR/PP interface [polypeptide binding]; other site 1206745002481 TPP binding site [chemical binding]; other site 1206745002482 dimer interface [polypeptide binding]; other site 1206745002483 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206745002484 TPP binding site [chemical binding]; other site 1206745002485 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1206745002486 TPP-binding site [chemical binding]; other site 1206745002487 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1206745002488 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1206745002489 active site 1206745002490 NAD binding site [chemical binding]; other site 1206745002491 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1206745002492 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1206745002493 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1206745002494 metal binding site [ion binding]; metal-binding site 1206745002495 TrkA-N domain; Region: TrkA_N; pfam02254 1206745002496 putative oxidoreductase; Provisional; Region: PRK11445 1206745002497 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1206745002498 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1206745002499 active site 1206745002500 NTP binding site [chemical binding]; other site 1206745002501 metal binding triad [ion binding]; metal-binding site 1206745002502 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1206745002503 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1206745002504 R.Pab1 restriction endonuclease; Region: RE_R_Pab1; pfam09522 1206745002505 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745002506 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1206745002507 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1206745002508 AMP/PPi binding site [chemical binding]; other site 1206745002509 candidate oxyanion hole; other site 1206745002510 catalytic triad [active] 1206745002511 potential glutamine specificity residues [chemical binding]; other site 1206745002512 GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519 1206745002513 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1206745002514 ATP Binding subdomain [chemical binding]; other site 1206745002515 Ligand Binding sites [chemical binding]; other site 1206745002516 Dimerization subdomain; other site 1206745002517 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1206745002518 arsenical pump membrane protein; Provisional; Region: PRK15445 1206745002519 transmembrane helices; other site 1206745002520 methionine sulfoxide reductase B; Provisional; Region: PRK05508 1206745002521 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1206745002522 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1206745002523 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1206745002524 substrate binding site [chemical binding]; other site 1206745002525 active site 1206745002526 catalytic residues [active] 1206745002527 heterodimer interface [polypeptide binding]; other site 1206745002528 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1206745002529 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1206745002530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002531 catalytic residue [active] 1206745002532 AIPR protein; Region: AIPR; pfam10592 1206745002533 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1206745002534 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1206745002535 Walker A/P-loop; other site 1206745002536 ATP binding site [chemical binding]; other site 1206745002537 Q-loop/lid; other site 1206745002538 ABC transporter signature motif; other site 1206745002539 Walker B; other site 1206745002540 D-loop; other site 1206745002541 H-loop/switch region; other site 1206745002542 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 1206745002543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206745002544 substrate binding pocket [chemical binding]; other site 1206745002545 membrane-bound complex binding site; other site 1206745002546 hinge residues; other site 1206745002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745002548 dimer interface [polypeptide binding]; other site 1206745002549 conserved gate region; other site 1206745002550 putative PBP binding loops; other site 1206745002551 ABC-ATPase subunit interface; other site 1206745002552 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1206745002553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745002554 dimer interface [polypeptide binding]; other site 1206745002555 conserved gate region; other site 1206745002556 putative PBP binding loops; other site 1206745002557 ABC-ATPase subunit interface; other site 1206745002558 Protein of unknown function DUF262; Region: DUF262; pfam03235 1206745002559 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1206745002560 Protein of unknown function DUF262; Region: DUF262; pfam03235 1206745002561 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1206745002562 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745002563 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745002564 RDD family; Region: RDD; pfam06271 1206745002565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745002566 active site 1206745002567 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1206745002568 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1206745002569 Family description; Region: UvrD_C_2; pfam13538 1206745002570 SAF-like; Region: SAF_2; pfam13144 1206745002571 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 1206745002572 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1206745002573 Flavoprotein; Region: Flavoprotein; pfam02441 1206745002574 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1206745002575 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1206745002576 active site 1206745002577 (T/H)XGH motif; other site 1206745002578 thymidylate kinase; Validated; Region: tmk; PRK00698 1206745002579 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1206745002580 TMP-binding site; other site 1206745002581 ATP-binding site [chemical binding]; other site 1206745002582 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1206745002583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745002584 active site 1206745002585 Homeodomain-like domain; Region: HTH_23; cl17451 1206745002586 CHASE3 domain; Region: CHASE3; cl05000 1206745002587 Cache domain; Region: Cache_1; pfam02743 1206745002588 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745002589 dimer interface [polypeptide binding]; other site 1206745002590 putative CheW interface [polypeptide binding]; other site 1206745002591 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745002592 dimer interface [polypeptide binding]; other site 1206745002593 putative CheW interface [polypeptide binding]; other site 1206745002594 heat shock protein 90; Provisional; Region: PRK05218 1206745002595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745002596 ATP binding site [chemical binding]; other site 1206745002597 Mg2+ binding site [ion binding]; other site 1206745002598 G-X-G motif; other site 1206745002599 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206745002600 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1206745002601 active site 1206745002602 nucleophile elbow; other site 1206745002603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745002604 FeS/SAM binding site; other site 1206745002605 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745002606 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 1206745002607 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 1206745002608 Predicted methyltransferases [General function prediction only]; Region: COG0313 1206745002609 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1206745002610 putative SAM binding site [chemical binding]; other site 1206745002611 putative homodimer interface [polypeptide binding]; other site 1206745002612 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1206745002613 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1206745002614 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206745002615 Protein of unknown function (DUF2861); Region: DUF2861; pfam11060 1206745002616 aspartate aminotransferase; Provisional; Region: PRK08636 1206745002617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206745002618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745002619 homodimer interface [polypeptide binding]; other site 1206745002620 catalytic residue [active] 1206745002621 homoserine dehydrogenase; Provisional; Region: PRK06349 1206745002622 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1206745002623 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1206745002624 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1206745002625 hypothetical protein; Reviewed; Region: PRK12497 1206745002626 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1206745002627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1206745002628 ABC-ATPase subunit interface; other site 1206745002629 dimer interface [polypeptide binding]; other site 1206745002630 putative PBP binding regions; other site 1206745002631 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206745002632 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1206745002633 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1206745002634 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1206745002635 intersubunit interface [polypeptide binding]; other site 1206745002636 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 1206745002637 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1206745002638 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1206745002639 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206745002640 NlpC/P60 family; Region: NLPC_P60; cl17555 1206745002641 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1206745002642 ArsC family; Region: ArsC; pfam03960 1206745002643 catalytic residue [active] 1206745002644 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1206745002645 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1206745002646 active site 1206745002647 chlorohydrolase; Provisional; Region: PRK08418 1206745002648 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 1206745002649 active site 1206745002650 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1206745002651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1206745002652 dihydroorotase; Provisional; Region: PRK08417 1206745002653 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1206745002654 active site 1206745002655 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1206745002656 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1206745002657 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1206745002658 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1206745002659 ATP binding site [chemical binding]; other site 1206745002660 Mg++ binding site [ion binding]; other site 1206745002661 motif III; other site 1206745002662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745002663 nucleotide binding region [chemical binding]; other site 1206745002664 ATP-binding site [chemical binding]; other site 1206745002665 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1206745002666 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1206745002667 DNA binding site [nucleotide binding] 1206745002668 active site 1206745002669 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 1206745002670 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 1206745002671 adenylate kinase; Reviewed; Region: adk; PRK00279 1206745002672 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1206745002673 AMP-binding site [chemical binding]; other site 1206745002674 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1206745002675 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1206745002676 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1206745002677 dimer interface [polypeptide binding]; other site 1206745002678 anticodon binding site; other site 1206745002679 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1206745002680 homodimer interface [polypeptide binding]; other site 1206745002681 motif 1; other site 1206745002682 active site 1206745002683 motif 2; other site 1206745002684 GAD domain; Region: GAD; pfam02938 1206745002685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206745002686 active site 1206745002687 motif 3; other site 1206745002688 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1206745002689 Response regulator receiver domain; Region: Response_reg; pfam00072 1206745002690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745002691 active site 1206745002692 phosphorylation site [posttranslational modification] 1206745002693 intermolecular recognition site; other site 1206745002694 dimerization interface [polypeptide binding]; other site 1206745002695 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1206745002696 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1206745002697 nucleotide binding pocket [chemical binding]; other site 1206745002698 K-X-D-G motif; other site 1206745002699 catalytic site [active] 1206745002700 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1206745002701 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1206745002702 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1206745002703 Dimer interface [polypeptide binding]; other site 1206745002704 BRCT sequence motif; other site 1206745002705 Domain of unknown function (DUF386); Region: DUF386; cl01047 1206745002706 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1206745002707 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1206745002708 metal binding site [ion binding]; metal-binding site 1206745002709 dimer interface [polypeptide binding]; other site 1206745002710 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1206745002711 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1206745002712 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745002713 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1206745002714 putative active site [active] 1206745002715 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1206745002716 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1206745002717 dimer interface [polypeptide binding]; other site 1206745002718 motif 1; other site 1206745002719 active site 1206745002720 motif 2; other site 1206745002721 motif 3; other site 1206745002722 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1206745002723 anticodon binding site; other site 1206745002724 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1206745002725 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1206745002726 active site 1206745002727 Zn binding site [ion binding]; other site 1206745002728 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1206745002729 putative metal binding site [ion binding]; other site 1206745002730 LPP20 lipoprotein; Region: LPP20; pfam02169 1206745002731 LPP20 lipoprotein; Region: LPP20; pfam02169 1206745002732 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1206745002733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1206745002734 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1206745002735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1206745002736 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1206745002737 HlyD family secretion protein; Region: HlyD_3; pfam13437 1206745002738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206745002739 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206745002740 Walker A/P-loop; other site 1206745002741 ATP binding site [chemical binding]; other site 1206745002742 Q-loop/lid; other site 1206745002743 ABC transporter signature motif; other site 1206745002744 Walker B; other site 1206745002745 D-loop; other site 1206745002746 H-loop/switch region; other site 1206745002747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206745002748 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206745002749 FtsX-like permease family; Region: FtsX; pfam02687 1206745002750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002751 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1206745002752 ThiS interaction site; other site 1206745002753 putative active site [active] 1206745002754 tetramer interface [polypeptide binding]; other site 1206745002755 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1206745002756 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1206745002757 putative substrate binding site [chemical binding]; other site 1206745002758 putative ATP binding site [chemical binding]; other site 1206745002759 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 1206745002760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206745002761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206745002762 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206745002763 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1206745002764 dimer interface [polypeptide binding]; other site 1206745002765 substrate binding site [chemical binding]; other site 1206745002766 metal binding sites [ion binding]; metal-binding site 1206745002767 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1206745002768 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1206745002769 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1206745002770 active site 1206745002771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206745002772 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1206745002773 active site 1206745002774 DNA binding site [nucleotide binding] 1206745002775 Int/Topo IB signature motif; other site 1206745002776 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1206745002777 Initiator Replication protein; Region: Rep_3; pfam01051 1206745002778 DJ-1 family protein; Region: not_thiJ; TIGR01383 1206745002779 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1206745002780 conserved cys residue [active] 1206745002781 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1206745002782 UGMP family protein; Validated; Region: PRK09604 1206745002783 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1206745002784 quinolinate synthetase; Provisional; Region: PRK09375 1206745002785 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 1206745002786 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1206745002787 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1206745002788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1206745002789 ligand binding site [chemical binding]; other site 1206745002790 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1206745002791 active site 1206745002792 dimerization interface [polypeptide binding]; other site 1206745002793 thiamine monophosphate kinase; Provisional; Region: PRK05731 1206745002794 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1206745002795 dimerization interface [polypeptide binding]; other site 1206745002796 ATP binding site [chemical binding]; other site 1206745002797 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 1206745002798 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1206745002799 dimerization interface [polypeptide binding]; other site 1206745002800 active site 1206745002801 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1206745002802 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1206745002803 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1206745002804 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 1206745002805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745002806 FeS/SAM binding site; other site 1206745002807 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1206745002808 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1206745002809 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206745002810 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206745002811 catalytic residue [active] 1206745002812 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1206745002813 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1206745002814 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1206745002815 Predicted helicase [General function prediction only]; Region: COG4889 1206745002816 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1206745002817 thiamine phosphate binding site [chemical binding]; other site 1206745002818 active site 1206745002819 pyrophosphate binding site [ion binding]; other site 1206745002820 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1206745002821 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1206745002822 dimerization interface [polypeptide binding]; other site 1206745002823 ATP binding site [chemical binding]; other site 1206745002824 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1206745002825 dimerization interface [polypeptide binding]; other site 1206745002826 ATP binding site [chemical binding]; other site 1206745002827 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1206745002828 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1206745002829 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206745002830 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1206745002831 Sporulation related domain; Region: SPOR; pfam05036 1206745002832 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206745002833 NlpC/P60 family; Region: NLPC_P60; pfam00877 1206745002834 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1206745002835 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206745002836 putative active site [active] 1206745002837 PhoH-like protein; Region: PhoH; pfam02562 1206745002838 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1206745002839 dimer interface [polypeptide binding]; other site 1206745002840 catalytic triad [active] 1206745002841 peroxidatic and resolving cysteines [active] 1206745002842 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1206745002843 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1206745002844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206745002845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206745002846 NifU-like domain; Region: NifU; cl00484 1206745002847 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1206745002848 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1206745002849 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1206745002850 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1206745002851 DctM-like transporters; Region: DctM; pfam06808 1206745002852 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1206745002853 Phosphate transporter family; Region: PHO4; pfam01384 1206745002854 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1206745002855 Domain of unknown function DUF21; Region: DUF21; pfam01595 1206745002856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1206745002857 Transporter associated domain; Region: CorC_HlyC; smart01091 1206745002858 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1206745002859 substrate binding site [chemical binding]; other site 1206745002860 active site 1206745002861 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1206745002862 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206745002863 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745002864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745002865 S-adenosylmethionine binding site [chemical binding]; other site 1206745002866 Predicted permease [General function prediction only]; Region: COG2056 1206745002867 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1206745002868 Predicted helicase [General function prediction only]; Region: COG4889 1206745002869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745002870 nucleotide binding region [chemical binding]; other site 1206745002871 ATP-binding site [chemical binding]; other site 1206745002872 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1206745002873 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1206745002874 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1206745002875 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 1206745002876 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1206745002877 active site 1206745002878 substrate binding site [chemical binding]; other site 1206745002879 metal binding site [ion binding]; metal-binding site 1206745002880 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1206745002881 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1206745002882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206745002883 RF-1 domain; Region: RF-1; pfam00472 1206745002884 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 1206745002885 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1206745002886 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 1206745002887 ATP cone domain; Region: ATP-cone; pfam03477 1206745002888 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1206745002889 active site 1206745002890 dimer interface [polypeptide binding]; other site 1206745002891 catalytic residues [active] 1206745002892 effector binding site; other site 1206745002893 R2 peptide binding site; other site 1206745002894 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1206745002895 dimer interface [polypeptide binding]; other site 1206745002896 FMN binding site [chemical binding]; other site 1206745002897 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1206745002898 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1206745002899 G1 box; other site 1206745002900 putative GEF interaction site [polypeptide binding]; other site 1206745002901 GTP/Mg2+ binding site [chemical binding]; other site 1206745002902 Switch I region; other site 1206745002903 G2 box; other site 1206745002904 G3 box; other site 1206745002905 Switch II region; other site 1206745002906 G4 box; other site 1206745002907 G5 box; other site 1206745002908 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1206745002909 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1206745002910 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206745002911 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206745002912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206745002913 catalytic residue [active] 1206745002914 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1206745002915 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1206745002916 substrate binding site [chemical binding]; other site 1206745002917 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1206745002918 substrate binding site [chemical binding]; other site 1206745002919 ligand binding site [chemical binding]; other site 1206745002920 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 1206745002921 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1206745002922 CPxP motif; other site 1206745002923 DsrE/DsrF-like family; Region: DrsE; pfam02635 1206745002924 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1206745002925 dimerization interface [polypeptide binding]; other site 1206745002926 putative ATP binding site [chemical binding]; other site 1206745002927 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1206745002928 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1206745002929 generic binding surface II; other site 1206745002930 generic binding surface I; other site 1206745002931 biotin synthase; Provisional; Region: PRK08508 1206745002932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745002933 FeS/SAM binding site; other site 1206745002934 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1206745002935 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1206745002936 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1206745002937 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1206745002938 domain interfaces; other site 1206745002939 active site 1206745002940 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1206745002941 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1206745002942 dimer interface [polypeptide binding]; other site 1206745002943 motif 1; other site 1206745002944 active site 1206745002945 motif 2; other site 1206745002946 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1206745002947 putative deacylase active site [active] 1206745002948 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206745002949 active site 1206745002950 motif 3; other site 1206745002951 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1206745002952 anticodon binding site; other site 1206745002953 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1206745002954 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1206745002955 tRNA; other site 1206745002956 putative tRNA binding site [nucleotide binding]; other site 1206745002957 putative NADP binding site [chemical binding]; other site 1206745002958 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1206745002959 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206745002960 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206745002961 substrate binding pocket [chemical binding]; other site 1206745002962 chain length determination region; other site 1206745002963 substrate-Mg2+ binding site; other site 1206745002964 catalytic residues [active] 1206745002965 aspartate-rich region 1; other site 1206745002966 active site lid residues [active] 1206745002967 aspartate-rich region 2; other site 1206745002968 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 1206745002969 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1206745002970 histidinol dehydrogenase; Region: hisD; TIGR00069 1206745002971 NAD binding site [chemical binding]; other site 1206745002972 dimerization interface [polypeptide binding]; other site 1206745002973 product binding site; other site 1206745002974 substrate binding site [chemical binding]; other site 1206745002975 zinc binding site [ion binding]; other site 1206745002976 catalytic residues [active] 1206745002977 malate:quinone oxidoreductase; Validated; Region: PRK05257 1206745002978 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1206745002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745002981 S-adenosylmethionine binding site [chemical binding]; other site 1206745002982 argininosuccinate lyase; Provisional; Region: PRK00855 1206745002983 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1206745002984 active sites [active] 1206745002985 tetramer interface [polypeptide binding]; other site 1206745002986 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1206745002987 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1206745002988 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1206745002989 META domain; Region: META; pfam03724 1206745002990 histidinol-phosphatase; Provisional; Region: PRK07328 1206745002991 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1206745002992 active site 1206745002993 dimer interface [polypeptide binding]; other site 1206745002994 DNA topoisomerase I; Validated; Region: PRK05582 1206745002995 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1206745002996 active site 1206745002997 interdomain interaction site; other site 1206745002998 putative metal-binding site [ion binding]; other site 1206745002999 nucleotide binding site [chemical binding]; other site 1206745003000 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1206745003001 domain I; other site 1206745003002 phosphate binding site [ion binding]; other site 1206745003003 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206745003004 domain III; other site 1206745003005 DNA binding groove [nucleotide binding] 1206745003006 catalytic site [active] 1206745003007 nucleotide binding site [chemical binding]; other site 1206745003008 domain II; other site 1206745003009 domain IV; other site 1206745003010 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206745003011 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206745003012 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1206745003013 flagellin B; Provisional; Region: PRK13588 1206745003014 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1206745003015 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1206745003016 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1206745003017 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1206745003018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 1206745003019 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1206745003020 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1206745003021 Sulfatase; Region: Sulfatase; cl17466 1206745003022 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1206745003023 BNR repeat-like domain; Region: BNR_2; pfam13088 1206745003024 aspartate aminotransferase; Provisional; Region: PRK05764 1206745003025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206745003026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745003027 homodimer interface [polypeptide binding]; other site 1206745003028 catalytic residue [active] 1206745003029 prenyltransferase; Reviewed; Region: ubiA; PRK12874 1206745003030 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206745003031 Colicin V production protein; Region: Colicin_V; pfam02674 1206745003032 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1206745003033 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1206745003034 dimer interface [polypeptide binding]; other site 1206745003035 putative anticodon binding site; other site 1206745003036 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1206745003037 motif 1; other site 1206745003038 active site 1206745003039 motif 2; other site 1206745003040 motif 3; other site 1206745003041 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1206745003042 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1206745003043 dimer interface [polypeptide binding]; other site 1206745003044 active site 1206745003045 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1206745003046 folate binding site [chemical binding]; other site 1206745003047 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 1206745003048 Sporulation related domain; Region: SPOR; pfam05036 1206745003049 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206745003050 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1206745003051 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1206745003052 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206745003053 putative trimer interface [polypeptide binding]; other site 1206745003054 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1206745003055 putative CoA binding site [chemical binding]; other site 1206745003056 putative trimer interface [polypeptide binding]; other site 1206745003057 putative active site [active] 1206745003058 putative substrate binding site [chemical binding]; other site 1206745003059 putative CoA binding site [chemical binding]; other site 1206745003060 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1206745003061 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1206745003062 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1206745003063 Competence protein; Region: Competence; pfam03772 1206745003064 replicative DNA helicase; Provisional; Region: PRK08506 1206745003065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1206745003066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1206745003067 Walker A motif; other site 1206745003068 ATP binding site [chemical binding]; other site 1206745003069 Walker B motif; other site 1206745003070 DNA binding loops [nucleotide binding] 1206745003071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206745003072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206745003073 dimer interface [polypeptide binding]; other site 1206745003074 phosphorylation site [posttranslational modification] 1206745003075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745003076 ATP binding site [chemical binding]; other site 1206745003077 Mg2+ binding site [ion binding]; other site 1206745003078 G-X-G motif; other site 1206745003079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206745003080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745003081 active site 1206745003082 phosphorylation site [posttranslational modification] 1206745003083 intermolecular recognition site; other site 1206745003084 dimerization interface [polypeptide binding]; other site 1206745003085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206745003086 DNA binding site [nucleotide binding] 1206745003087 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 1206745003088 hypothetical protein; Provisional; Region: PRK10621 1206745003089 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1206745003090 GTP cyclohydrolase I; Provisional; Region: PLN03044 1206745003091 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1206745003092 active site 1206745003093 heat shock protein HtpX; Provisional; Region: PRK02870 1206745003094 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1206745003095 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1206745003096 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1206745003097 active site 1206745003098 ATP-binding site [chemical binding]; other site 1206745003099 pantoate-binding site; other site 1206745003100 HXXH motif; other site 1206745003101 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1206745003102 active site 1206745003103 dimer interface [polypeptide binding]; other site 1206745003104 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1206745003105 putative RNA binding site [nucleotide binding]; other site 1206745003106 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1206745003107 homopentamer interface [polypeptide binding]; other site 1206745003108 active site 1206745003109 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1206745003110 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1206745003111 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1206745003112 active site clefts [active] 1206745003113 zinc binding site [ion binding]; other site 1206745003114 dimer interface [polypeptide binding]; other site 1206745003115 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1206745003116 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206745003117 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1206745003118 dimerization interface [polypeptide binding]; other site 1206745003119 active site 1206745003120 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1206745003121 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1206745003122 dimer interface [polypeptide binding]; other site 1206745003123 putative functional site; other site 1206745003124 putative MPT binding site; other site 1206745003125 ThiS family; Region: ThiS; pfam02597 1206745003126 charged pocket; other site 1206745003127 hydrophobic patch; other site 1206745003128 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1206745003129 MoaE homodimer interface [polypeptide binding]; other site 1206745003130 MoaD interaction [polypeptide binding]; other site 1206745003131 active site residues [active] 1206745003132 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1206745003133 Walker A motif; other site 1206745003134 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1206745003135 MPT binding site; other site 1206745003136 trimer interface [polypeptide binding]; other site 1206745003137 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1206745003138 trimer interface [polypeptide binding]; other site 1206745003139 dimer interface [polypeptide binding]; other site 1206745003140 putative active site [active] 1206745003141 RmuC family; Region: RmuC; pfam02646 1206745003142 L-aspartate oxidase; Provisional; Region: PRK06175 1206745003143 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1206745003144 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206745003145 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1206745003146 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1206745003147 GIY-YIG motif/motif A; other site 1206745003148 active site 1206745003149 catalytic site [active] 1206745003150 putative DNA binding site [nucleotide binding]; other site 1206745003151 metal binding site [ion binding]; metal-binding site 1206745003152 UvrB/uvrC motif; Region: UVR; pfam02151 1206745003153 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1206745003154 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1206745003155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206745003156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1206745003157 dimer interface [polypeptide binding]; other site 1206745003158 phosphorylation site [posttranslational modification] 1206745003159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745003160 ATP binding site [chemical binding]; other site 1206745003161 G-X-G motif; other site 1206745003162 Response regulator receiver domain; Region: Response_reg; pfam00072 1206745003163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745003164 active site 1206745003165 phosphorylation site [posttranslational modification] 1206745003166 intermolecular recognition site; other site 1206745003167 dimerization interface [polypeptide binding]; other site 1206745003168 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 1206745003169 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1206745003170 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1206745003171 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1206745003172 RNA binding site [nucleotide binding]; other site 1206745003173 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1206745003174 multimer interface [polypeptide binding]; other site 1206745003175 Walker A motif; other site 1206745003176 ATP binding site [chemical binding]; other site 1206745003177 Walker B motif; other site 1206745003178 glutamate racemase; Provisional; Region: PRK00865 1206745003179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003180 FeS/SAM binding site; other site 1206745003181 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745003182 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1206745003183 active site 1206745003184 oxyanion hole [active] 1206745003185 catalytic triad [active] 1206745003186 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1206745003187 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1206745003188 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206745003189 TPP-binding site [chemical binding]; other site 1206745003190 dimer interface [polypeptide binding]; other site 1206745003191 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206745003192 PYR/PP interface [polypeptide binding]; other site 1206745003193 dimer interface [polypeptide binding]; other site 1206745003194 TPP binding site [chemical binding]; other site 1206745003195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206745003196 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 1206745003197 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1206745003198 putative tRNA-binding site [nucleotide binding]; other site 1206745003199 tRNA synthetase B5 domain; Region: B5; smart00874 1206745003200 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1206745003201 dimer interface [polypeptide binding]; other site 1206745003202 motif 1; other site 1206745003203 motif 3; other site 1206745003204 motif 2; other site 1206745003205 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1206745003206 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1206745003207 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1206745003208 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1206745003209 dimer interface [polypeptide binding]; other site 1206745003210 motif 1; other site 1206745003211 active site 1206745003212 motif 2; other site 1206745003213 motif 3; other site 1206745003214 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1206745003215 nucleotide binding site/active site [active] 1206745003216 HIT family signature motif; other site 1206745003217 catalytic residue [active] 1206745003218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003219 S-adenosylmethionine binding site [chemical binding]; other site 1206745003220 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1206745003221 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1206745003222 flagellin modification protein A; Provisional; Region: PRK09186 1206745003223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745003224 NAD(P) binding site [chemical binding]; other site 1206745003225 active site 1206745003226 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1206745003227 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 1206745003228 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1206745003229 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1206745003230 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1206745003231 substrate binding site; other site 1206745003232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003233 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1206745003234 FeS/SAM binding site; other site 1206745003235 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745003236 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1206745003237 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1206745003238 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1206745003239 G1 box; other site 1206745003240 GTP/Mg2+ binding site [chemical binding]; other site 1206745003241 Switch I region; other site 1206745003242 G2 box; other site 1206745003243 G3 box; other site 1206745003244 Switch II region; other site 1206745003245 G4 box; other site 1206745003246 G5 box; other site 1206745003247 Nucleoside recognition; Region: Gate; pfam07670 1206745003248 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1206745003249 Nucleoside recognition; Region: Gate; pfam07670 1206745003250 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1206745003251 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1206745003252 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206745003253 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206745003254 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206745003255 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206745003256 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 1206745003257 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1206745003258 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1206745003259 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745003260 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1206745003261 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1206745003262 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1206745003263 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1206745003264 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1206745003265 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1206745003266 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1206745003267 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1206745003268 catalytic residue [active] 1206745003269 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1206745003270 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1206745003271 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1206745003272 G1 box; other site 1206745003273 GTP/Mg2+ binding site [chemical binding]; other site 1206745003274 Switch I region; other site 1206745003275 G2 box; other site 1206745003276 Switch II region; other site 1206745003277 G3 box; other site 1206745003278 G4 box; other site 1206745003279 G5 box; other site 1206745003280 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1206745003281 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1206745003282 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1206745003283 membrane protein insertase; Provisional; Region: PRK01318 1206745003284 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1206745003285 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1206745003286 flagellar motor protein MotS; Reviewed; Region: PRK06925 1206745003287 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1206745003288 ligand binding site [chemical binding]; other site 1206745003289 Tht1-like nuclear fusion protein; Region: Tht1; pfam04163 1206745003290 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1206745003291 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1206745003292 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 1206745003293 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1206745003294 SmpB-tmRNA interface; other site 1206745003295 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 1206745003296 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1206745003297 carbon storage regulator; Provisional; Region: PRK00568 1206745003298 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 1206745003299 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1206745003300 RNA binding site [nucleotide binding]; other site 1206745003301 active site 1206745003302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1206745003303 PAS domain; Region: PAS_9; pfam13426 1206745003304 putative active site [active] 1206745003305 heme pocket [chemical binding]; other site 1206745003306 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1206745003307 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1206745003308 TPR repeat; Region: TPR_11; pfam13414 1206745003309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1206745003310 binding surface 1206745003311 TPR motif; other site 1206745003312 TPR repeat; Region: TPR_11; pfam13414 1206745003313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1206745003314 binding surface 1206745003315 TPR motif; other site 1206745003316 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 1206745003317 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1206745003318 active site 1206745003319 catalytic triad [active] 1206745003320 dimer interface [polypeptide binding]; other site 1206745003321 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 1206745003322 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1206745003323 putative NAD(P) binding site [chemical binding]; other site 1206745003324 active site 1206745003325 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1206745003326 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1206745003327 dimer interface [polypeptide binding]; other site 1206745003328 active site 1206745003329 catalytic residue [active] 1206745003330 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1206745003331 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1206745003332 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1206745003333 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1206745003334 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1206745003335 quinone interaction residues [chemical binding]; other site 1206745003336 active site 1206745003337 catalytic residues [active] 1206745003338 FMN binding site [chemical binding]; other site 1206745003339 substrate binding site [chemical binding]; other site 1206745003340 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1206745003341 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1206745003342 putative active site [active] 1206745003343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003345 S-adenosylmethionine binding site [chemical binding]; other site 1206745003346 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1206745003347 classical (c) SDRs; Region: SDR_c; cd05233 1206745003348 NAD(P) binding site [chemical binding]; other site 1206745003349 active site 1206745003350 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1206745003351 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745003352 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003354 S-adenosylmethionine binding site [chemical binding]; other site 1206745003355 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745003356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003357 S-adenosylmethionine binding site [chemical binding]; other site 1206745003358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003359 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1206745003360 FeS/SAM binding site; other site 1206745003361 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206745003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003363 S-adenosylmethionine binding site [chemical binding]; other site 1206745003364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003365 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1206745003366 FeS/SAM binding site; other site 1206745003367 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745003368 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1206745003369 classical (c) SDRs; Region: SDR_c; cd05233 1206745003370 NAD(P) binding site [chemical binding]; other site 1206745003371 active site 1206745003372 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1206745003373 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206745003374 PYR/PP interface [polypeptide binding]; other site 1206745003375 dimer interface [polypeptide binding]; other site 1206745003376 TPP binding site [chemical binding]; other site 1206745003377 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206745003378 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206745003379 TPP-binding site [chemical binding]; other site 1206745003380 dimer interface [polypeptide binding]; other site 1206745003381 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206745003382 TPP-binding site [chemical binding]; other site 1206745003383 dimer interface [polypeptide binding]; other site 1206745003384 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206745003385 PYR/PP interface [polypeptide binding]; other site 1206745003386 dimer interface [polypeptide binding]; other site 1206745003387 TPP binding site [chemical binding]; other site 1206745003388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003389 S-adenosylmethionine binding site [chemical binding]; other site 1206745003390 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745003391 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1206745003392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003393 FeS/SAM binding site; other site 1206745003394 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1206745003395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003396 FeS/SAM binding site; other site 1206745003397 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1206745003398 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1206745003399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745003400 FeS/SAM binding site; other site 1206745003401 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206745003402 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206745003403 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206745003404 putative acyl-acceptor binding pocket; other site 1206745003405 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1206745003406 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1206745003407 putative active site [active] 1206745003408 catalytic triad [active] 1206745003409 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1206745003410 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1206745003411 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1206745003412 ATP binding site [chemical binding]; other site 1206745003413 active site 1206745003414 substrate binding site [chemical binding]; other site 1206745003415 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1206745003416 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1206745003417 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1206745003418 protein binding site [polypeptide binding]; other site 1206745003419 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1206745003420 Catalytic dyad [active] 1206745003421 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1206745003422 active site 1206745003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745003424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206745003425 putative substrate translocation pore; other site 1206745003426 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1206745003427 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1206745003428 Ligand Binding Site [chemical binding]; other site 1206745003429 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 1206745003430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206745003431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745003432 active site 1206745003433 phosphorylation site [posttranslational modification] 1206745003434 intermolecular recognition site; other site 1206745003435 dimerization interface [polypeptide binding]; other site 1206745003436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206745003437 DNA binding site [nucleotide binding] 1206745003438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206745003439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745003440 ATP binding site [chemical binding]; other site 1206745003441 Mg2+ binding site [ion binding]; other site 1206745003442 G-X-G motif; other site 1206745003443 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1206745003444 dimer interface [polypeptide binding]; other site 1206745003445 active site 1206745003446 Schiff base residues; other site 1206745003447 hypothetical protein; Provisional; Region: PRK12378 1206745003448 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1206745003449 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1206745003450 Sel1-like repeats; Region: SEL1; smart00671 1206745003451 Sel1-like repeats; Region: SEL1; smart00671 1206745003452 Sel1-like repeats; Region: SEL1; smart00671 1206745003453 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1206745003454 Sel1-like repeats; Region: SEL1; smart00671 1206745003455 Sel1 repeat; Region: Sel1; cl02723 1206745003456 Sel1-like repeats; Region: SEL1; smart00671 1206745003457 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1206745003458 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1206745003459 pantothenate kinase; Reviewed; Region: PRK13333 1206745003460 PQQ-like domain; Region: PQQ_2; pfam13360 1206745003461 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1206745003462 trimer interface [polypeptide binding]; other site 1206745003463 active site 1206745003464 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1206745003465 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1206745003466 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1206745003467 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1206745003468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206745003469 active site 1206745003470 motif I; other site 1206745003471 motif II; other site 1206745003472 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1206745003473 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206745003474 molybdopterin cofactor binding site; other site 1206745003475 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206745003476 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1206745003477 molybdopterin cofactor binding site; other site 1206745003478 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1206745003479 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206745003480 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1206745003481 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1206745003482 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206745003483 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1206745003484 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1206745003485 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1206745003486 structural tetrad; other site 1206745003487 NapD protein; Region: NapD; cl01163 1206745003488 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1206745003489 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1206745003490 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1206745003491 apolar tunnel; other site 1206745003492 heme binding site [chemical binding]; other site 1206745003493 dimerization interface [polypeptide binding]; other site 1206745003494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1206745003495 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206745003496 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206745003497 ligand binding site [chemical binding]; other site 1206745003498 non-specific DNA interactions [nucleotide binding]; other site 1206745003499 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1206745003500 DNA binding site [nucleotide binding] 1206745003501 sequence specific DNA binding site [nucleotide binding]; other site 1206745003502 putative cAMP binding site [chemical binding]; other site 1206745003503 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1206745003504 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1206745003505 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1206745003506 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1206745003507 Ligand binding site; other site 1206745003508 oligomer interface; other site 1206745003509 Predicted membrane protein [Function unknown]; Region: COG2246 1206745003510 GtrA-like protein; Region: GtrA; pfam04138 1206745003511 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1206745003512 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745003513 dimer interface [polypeptide binding]; other site 1206745003514 putative CheW interface [polypeptide binding]; other site 1206745003515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745003516 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745003517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745003518 active site 1206745003519 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1206745003520 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1206745003521 Ligand binding site; other site 1206745003522 Putative Catalytic site; other site 1206745003523 DXD motif; other site 1206745003524 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1206745003525 HD domain; Region: HD_3; pfam13023 1206745003526 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206745003527 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1206745003528 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1206745003529 NADP-binding site; other site 1206745003530 homotetramer interface [polypeptide binding]; other site 1206745003531 substrate binding site [chemical binding]; other site 1206745003532 homodimer interface [polypeptide binding]; other site 1206745003533 active site 1206745003534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206745003535 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206745003536 Walker A/P-loop; other site 1206745003537 ATP binding site [chemical binding]; other site 1206745003538 Q-loop/lid; other site 1206745003539 ABC transporter signature motif; other site 1206745003540 Walker B; other site 1206745003541 D-loop; other site 1206745003542 H-loop/switch region; other site 1206745003543 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1206745003544 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1206745003545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745003546 dimer interface [polypeptide binding]; other site 1206745003547 conserved gate region; other site 1206745003548 putative PBP binding loops; other site 1206745003549 ABC-ATPase subunit interface; other site 1206745003550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206745003551 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1206745003552 Walker A/P-loop; other site 1206745003553 ATP binding site [chemical binding]; other site 1206745003554 Q-loop/lid; other site 1206745003555 ABC transporter signature motif; other site 1206745003556 Walker B; other site 1206745003557 D-loop; other site 1206745003558 H-loop/switch region; other site 1206745003559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745003560 dimer interface [polypeptide binding]; other site 1206745003561 conserved gate region; other site 1206745003562 putative PBP binding loops; other site 1206745003563 ABC-ATPase subunit interface; other site 1206745003564 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1206745003565 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1206745003566 substrate binding site [chemical binding]; other site 1206745003567 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1206745003568 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1206745003569 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1206745003570 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1206745003571 NADP binding site [chemical binding]; other site 1206745003572 active site 1206745003573 putative substrate binding site [chemical binding]; other site 1206745003574 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1206745003575 nucleotide binding site [chemical binding]; other site 1206745003576 homotetrameric interface [polypeptide binding]; other site 1206745003577 putative phosphate binding site [ion binding]; other site 1206745003578 putative allosteric binding site; other site 1206745003579 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1206745003580 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1206745003581 putative active site [active] 1206745003582 substrate binding site [chemical binding]; other site 1206745003583 putative cosubstrate binding site; other site 1206745003584 catalytic site [active] 1206745003585 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1206745003586 substrate binding site [chemical binding]; other site 1206745003587 biotin--protein ligase; Provisional; Region: PRK08477 1206745003588 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1206745003589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1206745003590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206745003591 P-loop; other site 1206745003592 Magnesium ion binding site [ion binding]; other site 1206745003593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206745003594 Magnesium ion binding site [ion binding]; other site 1206745003595 ParB-like nuclease domain; Region: ParBc; pfam02195 1206745003596 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1206745003597 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 1206745003598 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1206745003599 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 1206745003600 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1206745003601 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 1206745003602 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1206745003603 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1206745003604 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206745003605 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1206745003606 beta subunit interaction interface [polypeptide binding]; other site 1206745003607 Walker A motif; other site 1206745003608 ATP binding site [chemical binding]; other site 1206745003609 Walker B motif; other site 1206745003610 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206745003611 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1206745003612 core domain interface [polypeptide binding]; other site 1206745003613 delta subunit interface [polypeptide binding]; other site 1206745003614 epsilon subunit interface [polypeptide binding]; other site 1206745003615 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1206745003616 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206745003617 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1206745003618 alpha subunit interaction interface [polypeptide binding]; other site 1206745003619 Walker A motif; other site 1206745003620 ATP binding site [chemical binding]; other site 1206745003621 Walker B motif; other site 1206745003622 inhibitor binding site; inhibition site 1206745003623 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206745003624 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1206745003625 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1206745003626 gamma subunit interface [polypeptide binding]; other site 1206745003627 epsilon subunit interface [polypeptide binding]; other site 1206745003628 LBP interface [polypeptide binding]; other site 1206745003629 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1206745003630 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1206745003631 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1206745003632 TolR protein; Region: tolR; TIGR02801 1206745003633 TonB C terminal; Region: TonB_2; pfam13103 1206745003634 translocation protein TolB; Provisional; Region: tolB; PRK04043 1206745003635 TolB amino-terminal domain; Region: TolB_N; pfam04052 1206745003636 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1206745003637 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1206745003638 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1206745003639 ligand binding site [chemical binding]; other site 1206745003640 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1206745003641 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1206745003642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1206745003643 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1206745003644 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 1206745003645 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1206745003646 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00095 1206745003647 Predicted membrane protein [Function unknown]; Region: COG2246 1206745003648 GtrA-like protein; Region: GtrA; pfam04138 1206745003649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745003650 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1206745003651 DXD motif; other site 1206745003652 Putative Catalytic site; other site 1206745003653 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1206745003654 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1206745003655 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1206745003656 hinge region; other site 1206745003657 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1206745003658 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1206745003659 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1206745003660 active site 1206745003661 dimer interface [polypeptide binding]; other site 1206745003662 motif 1; other site 1206745003663 motif 2; other site 1206745003664 motif 3; other site 1206745003665 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1206745003666 anticodon binding site; other site 1206745003667 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1206745003668 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1206745003669 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1206745003670 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1206745003671 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1206745003672 23S rRNA binding site [nucleotide binding]; other site 1206745003673 L21 binding site [polypeptide binding]; other site 1206745003674 L13 binding site [polypeptide binding]; other site 1206745003675 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1206745003676 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206745003677 putative active site [active] 1206745003678 putative metal binding site [ion binding]; other site 1206745003679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1206745003680 TPR motif; other site 1206745003681 seryl-tRNA synthetase; Provisional; Region: PRK05431 1206745003682 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1206745003683 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1206745003684 dimer interface [polypeptide binding]; other site 1206745003685 active site 1206745003686 motif 1; other site 1206745003687 motif 2; other site 1206745003688 motif 3; other site 1206745003689 sec-independent translocase; Provisional; Region: PRK04098 1206745003690 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1206745003691 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 1206745003692 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1206745003693 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1206745003694 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1206745003695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1206745003696 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1206745003697 CheB methylesterase; Region: CheB_methylest; pfam01339 1206745003698 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1206745003699 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1206745003700 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1206745003701 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1206745003702 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206745003703 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1206745003704 protein binding site [polypeptide binding]; other site 1206745003705 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1206745003706 protein binding site [polypeptide binding]; other site 1206745003707 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1206745003708 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206745003709 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1206745003710 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206745003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745003712 Walker A/P-loop; other site 1206745003713 ATP binding site [chemical binding]; other site 1206745003714 Q-loop/lid; other site 1206745003715 ABC transporter signature motif; other site 1206745003716 Walker B; other site 1206745003717 D-loop; other site 1206745003718 H-loop/switch region; other site 1206745003719 ABC transporter; Region: ABC_tran_2; pfam12848 1206745003720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206745003721 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1206745003722 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1206745003723 homodimer interface [polypeptide binding]; other site 1206745003724 substrate-cofactor binding pocket; other site 1206745003725 catalytic residue [active] 1206745003726 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206745003727 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1206745003728 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1206745003729 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1206745003730 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1206745003731 metal binding site [ion binding]; metal-binding site 1206745003732 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 1206745003733 Cache domain; Region: Cache_1; pfam02743 1206745003734 GTP-binding protein Der; Reviewed; Region: PRK00093 1206745003735 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1206745003736 G1 box; other site 1206745003737 GTP/Mg2+ binding site [chemical binding]; other site 1206745003738 Switch I region; other site 1206745003739 G2 box; other site 1206745003740 Switch II region; other site 1206745003741 G3 box; other site 1206745003742 G4 box; other site 1206745003743 G5 box; other site 1206745003744 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1206745003745 G1 box; other site 1206745003746 GTP/Mg2+ binding site [chemical binding]; other site 1206745003747 Switch I region; other site 1206745003748 G2 box; other site 1206745003749 G3 box; other site 1206745003750 Switch II region; other site 1206745003751 G4 box; other site 1206745003752 G5 box; other site 1206745003753 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1206745003754 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1206745003755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745003756 active site 1206745003757 Family description; Region: DsbD_2; pfam13386 1206745003758 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745003759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745003760 S-adenosylmethionine binding site [chemical binding]; other site 1206745003761 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745003762 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1206745003763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745003764 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1206745003765 AAA domain; Region: AAA_12; pfam13087 1206745003766 Histone acetyl transferase HAT1 N-terminus; Region: Hat1_N; pfam10394 1206745003767 AAA domain; Region: AAA_30; pfam13604 1206745003768 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 1206745003769 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1206745003770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745003771 ATP binding site [chemical binding]; other site 1206745003772 putative Mg++ binding site [ion binding]; other site 1206745003773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745003774 nucleotide binding region [chemical binding]; other site 1206745003775 ATP-binding site [chemical binding]; other site 1206745003776 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1206745003777 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1206745003778 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1206745003779 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206745003780 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745003781 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745003782 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206745003783 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1206745003784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206745003785 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1206745003786 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1206745003787 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1206745003788 HIGH motif; other site 1206745003789 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206745003790 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1206745003791 active site 1206745003792 KMSKS motif; other site 1206745003793 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1206745003794 tRNA binding surface [nucleotide binding]; other site 1206745003795 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1206745003796 ParB-like nuclease domain; Region: ParB; smart00470 1206745003797 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1206745003798 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1206745003799 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1206745003800 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 1206745003801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206745003802 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1206745003803 active site 1206745003804 DNA binding site [nucleotide binding] 1206745003805 Int/Topo IB signature motif; other site 1206745003806 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1206745003807 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 1206745003808 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1206745003809 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 1206745003810 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 1206745003811 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1206745003812 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 1206745003813 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206745003814 AAA-like domain; Region: AAA_10; pfam12846 1206745003815 Walker A motif; other site 1206745003816 ATP binding site [chemical binding]; other site 1206745003817 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1206745003818 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206745003819 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1206745003820 active site 1206745003821 metal binding site [ion binding]; metal-binding site 1206745003822 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1206745003823 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1206745003824 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745003825 DNA methylase; Region: N6_N4_Mtase; cl17433 1206745003826 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1206745003827 GIY-YIG motif/motif A; other site 1206745003828 active site 1206745003829 catalytic site [active] 1206745003830 metal binding site [ion binding]; metal-binding site 1206745003831 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1206745003832 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1206745003833 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1206745003834 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1206745003835 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1206745003836 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003837 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003838 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1206745003839 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206745003840 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206745003841 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003842 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003843 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206745003844 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 1206745003845 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003846 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003847 hypothetical protein; Provisional; Region: PRK13688 1206745003848 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003849 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003850 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 1206745003851 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003852 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003853 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003854 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003855 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003856 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1206745003857 active site 1206745003858 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003859 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206745003860 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206745003861 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1206745003862 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1206745003863 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1206745003864 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003865 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003866 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1206745003867 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1206745003868 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1206745003869 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1206745003870 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1206745003871 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003872 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003873 ribonuclease; Region: Ribonuclease; pfam00545 1206745003874 active site 1206745003875 Casein kinase II regulatory subunit; Region: CK_II_beta; cl02099 1206745003876 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1206745003877 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1206745003878 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1206745003879 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1206745003880 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1206745003881 TIGR02594 family protein; Region: TIGR02594 1206745003882 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003883 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003884 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1206745003885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1206745003886 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745003887 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745003888 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003889 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003890 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003891 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1206745003892 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1206745003893 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1206745003894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206745003895 nucleophilic elbow; other site 1206745003896 catalytic triad; other site 1206745003897 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1206745003898 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1206745003899 nucleophilic elbow; other site 1206745003900 catalytic triad; other site 1206745003901 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1206745003902 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1206745003903 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1206745003904 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1206745003905 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1206745003906 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1206745003907 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1206745003908 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1206745003909 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1206745003910 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1206745003911 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1206745003912 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1206745003913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206745003914 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1206745003915 active site 1206745003916 metal binding site [ion binding]; metal-binding site 1206745003917 Fic/DOC family; Region: Fic; pfam02661 1206745003918 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1206745003919 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1206745003920 Fic family protein [Function unknown]; Region: COG3177 1206745003921 Fic/DOC family; Region: Fic; pfam02661 1206745003922 PemK-like protein; Region: PemK; pfam02452 1206745003923 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1206745003924 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1206745003925 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1206745003926 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206745003927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745003928 ATP binding site [chemical binding]; other site 1206745003929 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1206745003930 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1206745003931 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1206745003932 SEA domain; Region: SEA; cl02507 1206745003933 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 1206745003934 PemK-like protein; Region: PemK; pfam02452 1206745003935 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 1206745003936 CHC2 zinc finger; Region: zf-CHC2; cl17510 1206745003937 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1206745003938 active site 1206745003939 metal binding site [ion binding]; metal-binding site 1206745003940 interdomain interaction site; other site 1206745003941 LabA_like proteins; Region: LabA_like; cd06167 1206745003942 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1206745003943 putative metal binding site [ion binding]; other site 1206745003944 RecT family; Region: RecT; cl04285 1206745003945 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1206745003946 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1206745003947 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1206745003948 Divergent AAA domain; Region: AAA_4; pfam04326 1206745003949 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 1206745003950 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1206745003951 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206745003952 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1206745003953 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1206745003954 FHIPEP family; Region: FHIPEP; pfam00771 1206745003955 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1206745003956 DHH family; Region: DHH; pfam01368 1206745003957 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1206745003958 active site 1206745003959 substrate binding site [chemical binding]; other site 1206745003960 cosubstrate binding site; other site 1206745003961 catalytic site [active] 1206745003962 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1206745003963 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1206745003964 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1206745003965 Na2 binding site [ion binding]; other site 1206745003966 putative substrate binding site 1 [chemical binding]; other site 1206745003967 Na binding site 1 [ion binding]; other site 1206745003968 putative substrate binding site 2 [chemical binding]; other site 1206745003969 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206745003970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1206745003971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206745003972 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1206745003973 Walker A/P-loop; other site 1206745003974 ATP binding site [chemical binding]; other site 1206745003975 Q-loop/lid; other site 1206745003976 ABC transporter signature motif; other site 1206745003977 Walker B; other site 1206745003978 D-loop; other site 1206745003979 H-loop/switch region; other site 1206745003980 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206745003981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745003982 Walker A motif; other site 1206745003983 ATP binding site [chemical binding]; other site 1206745003984 Walker B motif; other site 1206745003985 arginine finger; other site 1206745003986 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1206745003987 AAA domain; Region: AAA_14; pfam13173 1206745003988 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1206745003989 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1206745003990 purine monophosphate binding site [chemical binding]; other site 1206745003991 dimer interface [polypeptide binding]; other site 1206745003992 putative catalytic residues [active] 1206745003993 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1206745003994 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1206745003995 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1206745003996 active site 1206745003997 catalytic site [active] 1206745003998 substrate binding site [chemical binding]; other site 1206745003999 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1206745004000 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1206745004001 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1206745004002 putative active site [active] 1206745004003 oxyanion strand; other site 1206745004004 catalytic triad [active] 1206745004005 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1206745004006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206745004007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206745004008 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1206745004009 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1206745004010 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1206745004011 amidophosphoribosyltransferase; Provisional; Region: PRK08525 1206745004012 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1206745004013 active site 1206745004014 tetramer interface [polypeptide binding]; other site 1206745004015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206745004016 active site 1206745004017 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1206745004018 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 1206745004019 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1206745004020 dimer interface [polypeptide binding]; other site 1206745004021 active site 1206745004022 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1206745004023 dimer interface [polypeptide binding]; other site 1206745004024 active site 1206745004025 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1206745004026 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1206745004027 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1206745004028 polyphosphate kinase; Provisional; Region: PRK05443 1206745004029 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1206745004030 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1206745004031 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1206745004032 putative domain interface [polypeptide binding]; other site 1206745004033 putative active site [active] 1206745004034 catalytic site [active] 1206745004035 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1206745004036 putative domain interface [polypeptide binding]; other site 1206745004037 putative active site [active] 1206745004038 catalytic site [active] 1206745004039 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 1206745004040 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1206745004041 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1206745004042 23S rRNA interface [nucleotide binding]; other site 1206745004043 L3 interface [polypeptide binding]; other site 1206745004044 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1206745004045 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206745004046 flagellar motor protein MotA; Validated; Region: PRK08456 1206745004047 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1206745004048 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 1206745004049 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1206745004050 ligand binding site [chemical binding]; other site 1206745004051 Cytochrome c; Region: Cytochrom_C; cl11414 1206745004052 elongation factor G; Reviewed; Region: PRK00007 1206745004053 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1206745004054 G1 box; other site 1206745004055 putative GEF interaction site [polypeptide binding]; other site 1206745004056 GTP/Mg2+ binding site [chemical binding]; other site 1206745004057 Switch I region; other site 1206745004058 G2 box; other site 1206745004059 G3 box; other site 1206745004060 Switch II region; other site 1206745004061 G4 box; other site 1206745004062 G5 box; other site 1206745004063 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1206745004064 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1206745004065 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1206745004066 30S ribosomal protein S7; Validated; Region: PRK05302 1206745004067 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1206745004068 S17 interaction site [polypeptide binding]; other site 1206745004069 S8 interaction site; other site 1206745004070 16S rRNA interaction site [nucleotide binding]; other site 1206745004071 streptomycin interaction site [chemical binding]; other site 1206745004072 23S rRNA interaction site [nucleotide binding]; other site 1206745004073 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1206745004074 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1206745004075 DNA binding site [nucleotide binding] 1206745004076 clamp; other site 1206745004077 Rpb1 - Rpb2 interaction site [polypeptide binding]; other site 1206745004078 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1206745004079 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 1206745004080 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1206745004081 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1206745004082 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1206745004083 RPB11 interaction site [polypeptide binding]; other site 1206745004084 RPB12 interaction site [polypeptide binding]; other site 1206745004085 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1206745004086 RPB3 interaction site [polypeptide binding]; other site 1206745004087 RPB1 interaction site [polypeptide binding]; other site 1206745004088 RPB11 interaction site [polypeptide binding]; other site 1206745004089 RPB10 interaction site [polypeptide binding]; other site 1206745004090 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1206745004091 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1206745004092 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1206745004093 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1206745004094 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1206745004095 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1206745004096 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1206745004097 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1206745004098 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1206745004099 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1206745004100 core dimer interface [polypeptide binding]; other site 1206745004101 peripheral dimer interface [polypeptide binding]; other site 1206745004102 L10 interface [polypeptide binding]; other site 1206745004103 L11 interface [polypeptide binding]; other site 1206745004104 putative EF-Tu interaction site [polypeptide binding]; other site 1206745004105 putative EF-G interaction site [polypeptide binding]; other site 1206745004106 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1206745004107 23S rRNA interface [nucleotide binding]; other site 1206745004108 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1206745004109 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1206745004110 mRNA/rRNA interface [nucleotide binding]; other site 1206745004111 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1206745004112 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1206745004113 23S rRNA interface [nucleotide binding]; other site 1206745004114 L7/L12 interface [polypeptide binding]; other site 1206745004115 putative thiostrepton binding site; other site 1206745004116 L25 interface [polypeptide binding]; other site 1206745004117 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1206745004118 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1206745004119 putative homodimer interface [polypeptide binding]; other site 1206745004120 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1206745004121 heterodimer interface [polypeptide binding]; other site 1206745004122 homodimer interface [polypeptide binding]; other site 1206745004123 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1206745004124 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1206745004125 elongation factor Tu; Reviewed; Region: PRK00049 1206745004126 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1206745004127 G1 box; other site 1206745004128 GEF interaction site [polypeptide binding]; other site 1206745004129 GTP/Mg2+ binding site [chemical binding]; other site 1206745004130 Switch I region; other site 1206745004131 G2 box; other site 1206745004132 G3 box; other site 1206745004133 Switch II region; other site 1206745004134 G4 box; other site 1206745004135 G5 box; other site 1206745004136 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1206745004137 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1206745004138 Antibiotic Binding Site [chemical binding]; other site 1206745004139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745004140 hypothetical protein; Provisional; Region: PRK05839 1206745004141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206745004142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745004143 homodimer interface [polypeptide binding]; other site 1206745004144 catalytic residue [active] 1206745004145 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1206745004146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206745004147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206745004148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206745004149 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1206745004150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745004151 Walker A/P-loop; other site 1206745004152 ATP binding site [chemical binding]; other site 1206745004153 Q-loop/lid; other site 1206745004154 ABC transporter signature motif; other site 1206745004155 Walker B; other site 1206745004156 D-loop; other site 1206745004157 H-loop/switch region; other site 1206745004158 Smr domain; Region: Smr; pfam01713 1206745004159 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1206745004160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745004161 dimer interface [polypeptide binding]; other site 1206745004162 putative CheW interface [polypeptide binding]; other site 1206745004163 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206745004164 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206745004165 inhibitor-cofactor binding pocket; inhibition site 1206745004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745004167 catalytic residue [active] 1206745004168 biotin carboxylase; Validated; Region: PRK08462 1206745004169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206745004170 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206745004171 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206745004172 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1206745004173 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206745004174 carboxyltransferase (CT) interaction site; other site 1206745004175 biotinylation site [posttranslational modification]; other site 1206745004176 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1206745004177 trimer interface [polypeptide binding]; other site 1206745004178 active site 1206745004179 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1206745004180 active site 1206745004181 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1206745004182 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1206745004183 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 1206745004184 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1206745004185 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1206745004186 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 1206745004187 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1206745004188 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1206745004189 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1206745004190 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745004191 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1206745004192 AAA domain; Region: AAA_14; pfam13173 1206745004193 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1206745004194 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1206745004195 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1206745004196 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1206745004197 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1206745004198 PLD-like domain; Region: PLDc_2; pfam13091 1206745004199 putative active site [active] 1206745004200 catalytic site [active] 1206745004201 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206745004202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745004203 ATP binding site [chemical binding]; other site 1206745004204 putative Mg++ binding site [ion binding]; other site 1206745004205 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206745004206 nucleotide binding region [chemical binding]; other site 1206745004207 Fic/DOC family; Region: Fic; pfam02661 1206745004208 Sel1 repeat; Region: Sel1; cl02723 1206745004209 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1206745004210 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1206745004211 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1206745004212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206745004213 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 1206745004214 NAD(P) binding site [chemical binding]; other site 1206745004215 active site 1206745004216 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1206745004217 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1206745004218 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1206745004219 dimer interface [polypeptide binding]; other site 1206745004220 Citrate synthase; Region: Citrate_synt; pfam00285 1206745004221 active site 1206745004222 citrylCoA binding site [chemical binding]; other site 1206745004223 oxalacetate/citrate binding site [chemical binding]; other site 1206745004224 coenzyme A binding site [chemical binding]; other site 1206745004225 catalytic triad [active] 1206745004226 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1206745004227 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1206745004228 tetramer interface [polypeptide binding]; other site 1206745004229 active site 1206745004230 Mg2+/Mn2+ binding site [ion binding]; other site 1206745004231 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1206745004232 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1206745004233 acyl-activating enzyme (AAE) consensus motif; other site 1206745004234 putative AMP binding site [chemical binding]; other site 1206745004235 putative active site [active] 1206745004236 putative CoA binding site [chemical binding]; other site 1206745004237 Pirin-related protein [General function prediction only]; Region: COG1741 1206745004238 Pirin; Region: Pirin; pfam02678 1206745004239 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1206745004240 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1206745004241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1206745004242 HlyD family secretion protein; Region: HlyD_3; pfam13437 1206745004243 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1206745004244 Predicted membrane protein [Function unknown]; Region: COG1238 1206745004245 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1206745004246 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 1206745004247 putative ligand binding site [chemical binding]; other site 1206745004248 putative NAD binding site [chemical binding]; other site 1206745004249 catalytic site [active] 1206745004250 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1206745004251 feedback inhibition sensing region; other site 1206745004252 homohexameric interface [polypeptide binding]; other site 1206745004253 nucleotide binding site [chemical binding]; other site 1206745004254 N-acetyl-L-glutamate binding site [chemical binding]; other site 1206745004255 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1206745004256 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1206745004257 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1206745004258 tetramer interfaces [polypeptide binding]; other site 1206745004259 binuclear metal-binding site [ion binding]; other site 1206745004260 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1206745004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745004262 active site 1206745004263 intermolecular recognition site; other site 1206745004264 dimerization interface [polypeptide binding]; other site 1206745004265 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1206745004266 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1206745004267 substrate binding site; other site 1206745004268 dimer interface; other site 1206745004269 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1206745004270 homotrimer interaction site [polypeptide binding]; other site 1206745004271 zinc binding site [ion binding]; other site 1206745004272 CDP-binding sites; other site 1206745004273 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1206745004274 ThiC family; Region: ThiC; pfam01964 1206745004275 YCII-related domain; Region: YCII; cl00999 1206745004276 GAD domain; Region: GAD; pfam02938 1206745004277 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1206745004278 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1206745004279 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1206745004280 flagellar motor switch protein; Validated; Region: PRK08433 1206745004281 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1206745004282 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1206745004283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206745004284 minor groove reading motif; other site 1206745004285 helix-hairpin-helix signature motif; other site 1206745004286 substrate binding pocket [chemical binding]; other site 1206745004287 active site 1206745004288 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1206745004289 FeoA domain; Region: FeoA; pfam04023 1206745004290 Protein of unknown function; Region: DUF3971; pfam13116 1206745004291 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 1206745004292 YceG-like family; Region: YceG; pfam02618 1206745004293 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1206745004294 dimerization interface [polypeptide binding]; other site 1206745004295 malate dehydrogenase; Reviewed; Region: PRK06223 1206745004296 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1206745004297 NAD(P) binding site [chemical binding]; other site 1206745004298 dimer interface [polypeptide binding]; other site 1206745004299 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206745004300 substrate binding site [chemical binding]; other site 1206745004301 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 1206745004302 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1206745004303 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 1206745004304 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1206745004305 dimer interface [polypeptide binding]; other site 1206745004306 PYR/PP interface [polypeptide binding]; other site 1206745004307 TPP binding site [chemical binding]; other site 1206745004308 substrate binding site [chemical binding]; other site 1206745004309 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 1206745004310 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1206745004311 TPP-binding site [chemical binding]; other site 1206745004312 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 1206745004313 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1206745004314 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1206745004315 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1206745004316 Clp amino terminal domain; Region: Clp_N; pfam02861 1206745004317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745004318 Walker A motif; other site 1206745004319 ATP binding site [chemical binding]; other site 1206745004320 Walker B motif; other site 1206745004321 arginine finger; other site 1206745004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745004323 Walker A motif; other site 1206745004324 ATP binding site [chemical binding]; other site 1206745004325 Walker B motif; other site 1206745004326 arginine finger; other site 1206745004327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206745004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1206745004329 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1206745004330 S1 domain; Region: S1_2; pfam13509 1206745004331 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1206745004332 malonic semialdehyde reductase; Provisional; Region: PRK10538 1206745004333 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1206745004334 putative NAD(P) binding site [chemical binding]; other site 1206745004335 homodimer interface [polypeptide binding]; other site 1206745004336 homotetramer interface [polypeptide binding]; other site 1206745004337 active site 1206745004338 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1206745004339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745004340 dimer interface [polypeptide binding]; other site 1206745004341 putative CheW interface [polypeptide binding]; other site 1206745004342 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1206745004343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745004344 Walker A motif; other site 1206745004345 ATP binding site [chemical binding]; other site 1206745004346 Walker B motif; other site 1206745004347 arginine finger; other site 1206745004348 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1206745004349 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1206745004350 oligomerization interface [polypeptide binding]; other site 1206745004351 active site 1206745004352 metal binding site [ion binding]; metal-binding site 1206745004353 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1206745004354 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1206745004355 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1206745004356 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1206745004357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206745004358 dimerization interface [polypeptide binding]; other site 1206745004359 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1206745004360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745004361 dimer interface [polypeptide binding]; other site 1206745004362 putative CheW interface [polypeptide binding]; other site 1206745004363 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1206745004364 RuvA N terminal domain; Region: RuvA_N; pfam01330 1206745004365 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1206745004366 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1206745004367 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1206745004368 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1206745004369 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1206745004370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206745004371 active site 1206745004372 HIGH motif; other site 1206745004373 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206745004374 KMSKS motif; other site 1206745004375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1206745004376 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1206745004377 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206745004378 active site 1206745004379 nucleotide binding site [chemical binding]; other site 1206745004380 HIGH motif; other site 1206745004381 KMSKS motif; other site 1206745004382 Riboflavin kinase; Region: Flavokinase; pfam01687 1206745004383 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1206745004384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206745004385 RNA binding surface [nucleotide binding]; other site 1206745004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745004387 S-adenosylmethionine binding site [chemical binding]; other site 1206745004388 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1206745004389 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206745004390 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206745004391 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 1206745004392 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1206745004393 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1206745004394 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1206745004395 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1206745004396 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1206745004397 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1206745004398 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1206745004399 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1206745004400 metal binding site [ion binding]; metal-binding site 1206745004401 dimer interface [polypeptide binding]; other site 1206745004402 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1206745004403 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1206745004404 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1206745004405 Helix-turn-helix domain; Region: HTH_36; pfam13730 1206745004406 DNA primase; Validated; Region: dnaG; PRK05667 1206745004407 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1206745004408 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1206745004409 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 1206745004410 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 1206745004411 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1206745004412 selenocysteine synthase; Provisional; Region: PRK04311 1206745004413 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1206745004414 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1206745004415 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1206745004416 G1 box; other site 1206745004417 putative GEF interaction site [polypeptide binding]; other site 1206745004418 GTP/Mg2+ binding site [chemical binding]; other site 1206745004419 Switch I region; other site 1206745004420 G2 box; other site 1206745004421 G3 box; other site 1206745004422 Switch II region; other site 1206745004423 G4 box; other site 1206745004424 G5 box; other site 1206745004425 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1206745004426 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1206745004427 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206745004428 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1206745004429 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1206745004430 dimer interface [polypeptide binding]; other site 1206745004431 putative functional site; other site 1206745004432 putative MPT binding site; other site 1206745004433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206745004434 Ligand Binding Site [chemical binding]; other site 1206745004435 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1206745004436 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1206745004437 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745004438 putative metal binding site; other site 1206745004439 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206745004440 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 1206745004441 Substrate binding site; other site 1206745004442 metal-binding site 1206745004443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745004444 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745004445 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1206745004446 putative ADP-binding pocket [chemical binding]; other site 1206745004447 Sulfatase; Region: Sulfatase; pfam00884 1206745004448 hypothetical protein; Provisional; Region: PRK10649 1206745004449 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 1206745004450 Sulfatase; Region: Sulfatase; pfam00884 1206745004451 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1206745004452 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1206745004453 cell division protein FtsZ; Validated; Region: PRK09330 1206745004454 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1206745004455 nucleotide binding site [chemical binding]; other site 1206745004456 SulA interaction site; other site 1206745004457 cell division protein FtsA; Region: ftsA; TIGR01174 1206745004458 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1206745004459 nucleotide binding site [chemical binding]; other site 1206745004460 Cell division protein FtsA; Region: FtsA; pfam14450 1206745004461 SurA N-terminal domain; Region: SurA_N_3; cl07813 1206745004462 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1206745004463 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1206745004464 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1206745004465 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206745004466 active site 1206745004467 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1206745004468 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1206745004469 Interdomain contacts; other site 1206745004470 Cytokine receptor motif; other site 1206745004471 Fibronectin type 3 domain; Region: FN3; smart00060 1206745004472 Interdomain contacts; other site 1206745004473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1206745004474 Interdomain contacts; other site 1206745004475 Cytokine receptor motif; other site 1206745004476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206745004477 S-adenosylmethionine binding site [chemical binding]; other site 1206745004478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206745004479 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206745004480 Walker A/P-loop; other site 1206745004481 ATP binding site [chemical binding]; other site 1206745004482 Q-loop/lid; other site 1206745004483 ABC transporter signature motif; other site 1206745004484 Walker B; other site 1206745004485 D-loop; other site 1206745004486 H-loop/switch region; other site 1206745004487 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1206745004488 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745004489 FlaG protein; Region: FlaG; cl00591 1206745004490 flagellar capping protein; Validated; Region: fliD; PRK08453 1206745004491 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1206745004492 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1206745004493 flagellar protein FliS; Validated; Region: fliS; PRK05685 1206745004494 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1206745004495 IHF - DNA interface [nucleotide binding]; other site 1206745004496 IHF dimer interface [polypeptide binding]; other site 1206745004497 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1206745004498 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206745004499 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1206745004500 Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AspS; COG0173 1206745004501 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1206745004502 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1206745004503 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1206745004504 GatB domain; Region: GatB_Yqey; smart00845 1206745004505 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1206745004506 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1206745004507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1206745004508 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1206745004509 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1206745004510 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1206745004511 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1206745004512 putative catalytic cysteine [active] 1206745004513 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1206745004514 GcpE protein; Region: GcpE; pfam04551 1206745004515 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1206745004516 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 1206745004517 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1206745004518 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1206745004519 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1206745004520 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1206745004521 Ligand binding site; other site 1206745004522 Putative Catalytic site; other site 1206745004523 DXD motif; other site 1206745004524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745004525 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206745004526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206745004527 Peptidase family M13; Region: Peptidase_M13_N; pfam05649 1206745004528 Predicted membrane protein [Function unknown]; Region: COG2246 1206745004529 GtrA-like protein; Region: GtrA; pfam04138 1206745004530 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1206745004531 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1206745004532 EamA-like transporter family; Region: EamA; pfam00892 1206745004533 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1206745004534 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1206745004535 Na2 binding site [ion binding]; other site 1206745004536 putative substrate binding site 1 [chemical binding]; other site 1206745004537 Na binding site 1 [ion binding]; other site 1206745004538 putative substrate binding site 2 [chemical binding]; other site 1206745004539 TfoX N-terminal domain; Region: TfoX_N; cl17592 1206745004540 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1206745004541 FAD binding site [chemical binding]; other site 1206745004542 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1206745004543 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1206745004544 THF binding site; other site 1206745004545 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1206745004546 substrate binding site [chemical binding]; other site 1206745004547 THF binding site; other site 1206745004548 zinc-binding site [ion binding]; other site 1206745004549 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 1206745004550 dimerization interface [polypeptide binding]; other site 1206745004551 substrate binding site [chemical binding]; other site 1206745004552 active site 1206745004553 calcium binding site [ion binding]; other site 1206745004554 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1206745004555 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1206745004556 glutaminase active site [active] 1206745004557 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1206745004558 dimer interface [polypeptide binding]; other site 1206745004559 active site 1206745004560 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1206745004561 dimer interface [polypeptide binding]; other site 1206745004562 active site 1206745004563 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206745004564 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1206745004565 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745004566 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745004567 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745004568 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745004569 DNA methylase; Region: N6_N4_Mtase; cl17433 1206745004570 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745004571 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745004572 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745004573 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745004574 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745004575 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1206745004576 alanine--tRNA ligase; Region: alaS; TIGR00344 1206745004577 motif 1; other site 1206745004578 active site 1206745004579 motif 2; other site 1206745004580 motif 3; other site 1206745004581 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1206745004582 DHHA1 domain; Region: DHHA1; pfam02272 1206745004583 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1206745004584 active site 1206745004585 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1206745004586 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 1206745004587 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1206745004588 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1206745004589 active site 1206745004590 hydrophilic channel; other site 1206745004591 dimerization interface [polypeptide binding]; other site 1206745004592 catalytic residues [active] 1206745004593 active site lid [active] 1206745004594 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1206745004595 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1206745004596 putative valine binding site [chemical binding]; other site 1206745004597 dimer interface [polypeptide binding]; other site 1206745004598 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1206745004599 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 1206745004600 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206745004601 PYR/PP interface [polypeptide binding]; other site 1206745004602 dimer interface [polypeptide binding]; other site 1206745004603 TPP binding site [chemical binding]; other site 1206745004604 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206745004605 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1206745004606 TPP-binding site [chemical binding]; other site 1206745004607 dimer interface [polypeptide binding]; other site 1206745004608 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1206745004609 Ferredoxin [Energy production and conversion]; Region: COG1146 1206745004610 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1206745004611 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206745004612 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1206745004613 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1206745004614 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1206745004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1206745004616 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 1206745004617 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 1206745004618 FAD binding domain; Region: FAD_binding_4; pfam01565 1206745004619 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1206745004620 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1206745004621 dimer interface [polypeptide binding]; other site 1206745004622 ADP-ribose binding site [chemical binding]; other site 1206745004623 active site 1206745004624 nudix motif; other site 1206745004625 metal binding site [ion binding]; metal-binding site 1206745004626 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206745004627 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206745004628 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1206745004629 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 1206745004630 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1206745004631 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1206745004632 Peptidase family C69; Region: Peptidase_C69; cl17793 1206745004633 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1206745004634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745004635 Walker B motif; other site 1206745004636 arginine finger; other site 1206745004637 Peptidase family M41; Region: Peptidase_M41; pfam01434 1206745004638 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1206745004639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1206745004640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1206745004641 FeS/SAM binding site; other site 1206745004642 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1206745004643 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1206745004644 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1206745004645 active site 1206745004646 dimer interface [polypeptide binding]; other site 1206745004647 metal binding site [ion binding]; metal-binding site 1206745004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 1206745004649 TrkA-C domain; Region: TrkA_C; pfam02080 1206745004650 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1206745004651 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1206745004652 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206745004653 active site 1206745004654 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1206745004655 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1206745004656 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1206745004657 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 1206745004658 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1206745004659 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1206745004660 Protein of unknown function, DUF462; Region: DUF462; cl01190 1206745004661 CRISPR-associated protein; Region: TIGR03986 1206745004662 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1206745004663 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1206745004664 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1206745004665 Mg++ binding site [ion binding]; other site 1206745004666 putative catalytic motif [active] 1206745004667 substrate binding site [chemical binding]; other site 1206745004668 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1206745004669 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1206745004670 catalytic residues [active] 1206745004671 catalytic nucleophile [active] 1206745004672 Presynaptic Site I dimer interface [polypeptide binding]; other site 1206745004673 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1206745004674 Synaptic Flat tetramer interface [polypeptide binding]; other site 1206745004675 Synaptic Site I dimer interface [polypeptide binding]; other site 1206745004676 DNA binding site [nucleotide binding] 1206745004677 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1206745004678 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1206745004679 putative catalytic motif [active] 1206745004680 substrate binding site [chemical binding]; other site 1206745004681 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1206745004682 Na2 binding site [ion binding]; other site 1206745004683 putative substrate binding site 1 [chemical binding]; other site 1206745004684 Na binding site 1 [ion binding]; other site 1206745004685 putative substrate binding site 2 [chemical binding]; other site 1206745004686 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1206745004687 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1206745004688 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1206745004689 catalytic site [active] 1206745004690 subunit interface [polypeptide binding]; other site 1206745004691 Protein of unknown function (DUF507); Region: DUF507; pfam04368 1206745004692 Transglycosylase; Region: Transgly; pfam00912 1206745004693 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1206745004694 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1206745004695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745004696 dimer interface [polypeptide binding]; other site 1206745004697 putative CheW interface [polypeptide binding]; other site 1206745004698 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1206745004699 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206745004700 metal binding site 2 [ion binding]; metal-binding site 1206745004701 putative DNA binding helix; other site 1206745004702 metal binding site 1 [ion binding]; metal-binding site 1206745004703 dimer interface [polypeptide binding]; other site 1206745004704 structural Zn2+ binding site [ion binding]; other site 1206745004705 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1206745004706 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1206745004707 Fic family protein [Function unknown]; Region: COG3177 1206745004708 Fic/DOC family; Region: Fic; pfam02661 1206745004709 ParA-like protein; Provisional; Region: PHA02518 1206745004710 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206745004711 P-loop; other site 1206745004712 Magnesium ion binding site [ion binding]; other site 1206745004713 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1206745004714 active site 1206745004715 catalytic residues [active] 1206745004716 DNA binding site [nucleotide binding] 1206745004717 Int/Topo IB signature motif; other site 1206745004718 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206745004719 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206745004720 dimer interface [polypeptide binding]; other site 1206745004721 ssDNA binding site [nucleotide binding]; other site 1206745004722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206745004723 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1206745004724 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1206745004725 Staphylococcal nuclease homologues; Region: SNc; smart00318 1206745004726 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1206745004727 Catalytic site; other site 1206745004728 hypothetical protein; Provisional; Region: PRK12705 1206745004729 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1206745004730 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1206745004731 active site 1206745004732 metal binding site [ion binding]; metal-binding site 1206745004733 interdomain interaction site; other site 1206745004734 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1206745004735 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1206745004736 active site 1206745004737 metal binding site [ion binding]; metal-binding site 1206745004738 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206745004739 domain I; other site 1206745004740 DNA binding groove [nucleotide binding] 1206745004741 phosphate binding site [ion binding]; other site 1206745004742 domain II; other site 1206745004743 domain III; other site 1206745004744 nucleotide binding site [chemical binding]; other site 1206745004745 catalytic site [active] 1206745004746 domain IV; other site 1206745004747 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1206745004748 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206745004749 Walker A motif; other site 1206745004750 ATP binding site [chemical binding]; other site 1206745004751 Walker B motif; other site 1206745004752 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1206745004753 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1206745004754 Walker A motif; other site 1206745004755 hexamer interface [polypeptide binding]; other site 1206745004756 ATP binding site [chemical binding]; other site 1206745004757 Walker B motif; other site 1206745004758 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1206745004759 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 1206745004760 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1206745004761 VirB7 interaction site; other site 1206745004762 VirB8 protein; Region: VirB8; cl01500 1206745004763 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 1206745004764 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1206745004765 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1206745004766 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1206745004767 threonine dehydratase; Provisional; Region: PRK08526 1206745004768 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1206745004769 tetramer interface [polypeptide binding]; other site 1206745004770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745004771 catalytic residue [active] 1206745004772 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1206745004773 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1206745004774 EamA-like transporter family; Region: EamA; pfam00892 1206745004775 EamA-like transporter family; Region: EamA; cl17759 1206745004776 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1206745004777 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1206745004778 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1206745004779 ligand binding site; other site 1206745004780 tetramer interface; other site 1206745004781 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1206745004782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745004783 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1206745004784 Walker A motif; other site 1206745004785 ATP binding site [chemical binding]; other site 1206745004786 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1206745004787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206745004788 catalytic residue [active] 1206745004789 pseudaminic acid synthase; Region: PseI; TIGR03586 1206745004790 NeuB family; Region: NeuB; pfam03102 1206745004791 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1206745004792 NeuB binding interface [polypeptide binding]; other site 1206745004793 putative substrate binding site [chemical binding]; other site 1206745004794 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1206745004795 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1206745004796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206745004797 Coenzyme A binding pocket [chemical binding]; other site 1206745004798 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1206745004799 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1206745004800 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1206745004801 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1206745004802 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1206745004803 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1206745004804 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1206745004805 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 1206745004806 GDP-Fucose binding site [chemical binding]; other site 1206745004807 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1206745004808 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1206745004809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745004810 Walker A/P-loop; other site 1206745004811 ATP binding site [chemical binding]; other site 1206745004812 Q-loop/lid; other site 1206745004813 ABC transporter signature motif; other site 1206745004814 Walker B; other site 1206745004815 D-loop; other site 1206745004816 H-loop/switch region; other site 1206745004817 ABC transporter; Region: ABC_tran_2; pfam12848 1206745004818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206745004819 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1206745004820 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1206745004821 cofactor binding site; other site 1206745004822 DNA binding site [nucleotide binding] 1206745004823 substrate interaction site [chemical binding]; other site 1206745004824 hypothetical protein; Provisional; Region: PRK05834 1206745004825 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1206745004826 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1206745004827 metal binding site [ion binding]; metal-binding site 1206745004828 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1206745004829 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206745004830 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1206745004831 putative active site [active] 1206745004832 putative metal binding site [ion binding]; other site 1206745004833 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1206745004834 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1206745004835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745004836 active site 1206745004837 phosphorylation site [posttranslational modification] 1206745004838 intermolecular recognition site; other site 1206745004839 dimerization interface [polypeptide binding]; other site 1206745004840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1206745004841 putative binding surface; other site 1206745004842 active site 1206745004843 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1206745004844 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1206745004845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745004846 ATP binding site [chemical binding]; other site 1206745004847 Mg2+ binding site [ion binding]; other site 1206745004848 G-X-G motif; other site 1206745004849 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1206745004850 Response regulator receiver domain; Region: Response_reg; pfam00072 1206745004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206745004852 active site 1206745004853 phosphorylation site [posttranslational modification] 1206745004854 intermolecular recognition site; other site 1206745004855 dimerization interface [polypeptide binding]; other site 1206745004856 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1206745004857 putative CheA interaction surface; other site 1206745004858 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1206745004859 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1206745004860 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1206745004861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206745004862 active site 1206745004863 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1206745004864 FAD binding site [chemical binding]; other site 1206745004865 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1206745004866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206745004867 motif II; other site 1206745004868 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1206745004869 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1206745004870 Substrate binding site; other site 1206745004871 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1206745004872 DNA ligase; Provisional; Region: PRK09125 1206745004873 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1206745004874 DNA binding site [nucleotide binding] 1206745004875 active site 1206745004876 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1206745004877 DNA binding site [nucleotide binding] 1206745004878 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1206745004879 active site 1206745004880 multimer interface [polypeptide binding]; other site 1206745004881 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1206745004882 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1206745004883 putative phosphate acyltransferase; Provisional; Region: PRK05331 1206745004884 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1206745004885 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1206745004886 dimer interface [polypeptide binding]; other site 1206745004887 active site 1206745004888 CoA binding pocket [chemical binding]; other site 1206745004889 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206745004890 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206745004891 metal-binding site [ion binding] 1206745004892 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206745004893 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206745004894 metal-binding site [ion binding] 1206745004895 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1206745004896 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1206745004897 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1206745004898 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206745004899 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206745004900 metal-binding site [ion binding] 1206745004901 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206745004902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206745004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745004904 Walker A/P-loop; other site 1206745004905 ATP binding site [chemical binding]; other site 1206745004906 Q-loop/lid; other site 1206745004907 ABC transporter signature motif; other site 1206745004908 Walker B; other site 1206745004909 D-loop; other site 1206745004910 H-loop/switch region; other site 1206745004911 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 1206745004912 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1206745004913 Iron-sulfur protein interface; other site 1206745004914 proximal heme binding site [chemical binding]; other site 1206745004915 distal heme binding site [chemical binding]; other site 1206745004916 dimer interface [polypeptide binding]; other site 1206745004917 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1206745004918 L-aspartate oxidase; Provisional; Region: PRK06175 1206745004919 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206745004920 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1206745004921 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1206745004922 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1206745004923 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1206745004924 putative active site [active] 1206745004925 catalytic site [active] 1206745004926 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1206745004927 putative active site [active] 1206745004928 catalytic site [active] 1206745004929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1206745004930 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1206745004931 heterotetramer interface [polypeptide binding]; other site 1206745004932 active site pocket [active] 1206745004933 cleavage site 1206745004934 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1206745004935 TrkA-N domain; Region: TrkA_N; pfam02254 1206745004936 TrkA-C domain; Region: TrkA_C; pfam02080 1206745004937 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1206745004938 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1206745004939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1206745004940 HlyD family secretion protein; Region: HlyD_3; pfam13437 1206745004941 Outer membrane efflux protein; Region: OEP; pfam02321 1206745004942 Outer membrane efflux protein; Region: OEP; pfam02321 1206745004943 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 1206745004944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206745004945 catalytic core [active] 1206745004946 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1206745004947 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1206745004948 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1206745004949 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206745004950 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1206745004951 MraW methylase family; Region: Methyltransf_5; cl17771 1206745004952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1206745004953 putative acyl-acceptor binding pocket; other site 1206745004954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1206745004955 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 1206745004956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745004957 FeS/SAM binding site; other site 1206745004958 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1206745004959 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1206745004960 molybdopterin cofactor binding site [chemical binding]; other site 1206745004961 substrate binding site [chemical binding]; other site 1206745004962 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1206745004963 molybdopterin cofactor binding site; other site 1206745004964 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1206745004965 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1206745004966 Flagellar FliJ protein; Region: FliJ; pfam02050 1206745004967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1206745004968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1206745004969 GDP-binding site [chemical binding]; other site 1206745004970 ACT binding site; other site 1206745004971 IMP binding site; other site 1206745004972 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293 1206745004973 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206745004974 motif 1; other site 1206745004975 dimer interface [polypeptide binding]; other site 1206745004976 active site 1206745004977 motif 2; other site 1206745004978 motif 3; other site 1206745004979 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1206745004980 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1206745004981 Ligand Binding Site [chemical binding]; other site 1206745004982 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1206745004983 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1206745004984 N-terminal plug; other site 1206745004985 ligand-binding site [chemical binding]; other site 1206745004986 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1206745004987 Aspartase; Region: Aspartase; cd01357 1206745004988 active sites [active] 1206745004989 tetramer interface [polypeptide binding]; other site 1206745004990 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1206745004991 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1206745004992 GSCFA family; Region: GSCFA; pfam08885 1206745004993 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1206745004994 nuclease NucT; Provisional; Region: PRK13912 1206745004995 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1206745004996 putative active site [active] 1206745004997 catalytic site [active] 1206745004998 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1206745004999 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1206745005000 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1206745005001 catalytic site [active] 1206745005002 G-X2-G-X-G-K; other site 1206745005003 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 1206745005004 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1206745005005 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1206745005006 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1206745005007 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1206745005008 active site 1206745005009 HIGH motif; other site 1206745005010 KMSK motif region; other site 1206745005011 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1206745005012 tRNA binding surface [nucleotide binding]; other site 1206745005013 anticodon binding site; other site 1206745005014 AzlC protein; Region: AzlC; cl00570 1206745005015 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1206745005016 flavodoxin FldA; Validated; Region: PRK09267 1206745005017 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1206745005018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1206745005019 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1206745005020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745005021 dimer interface [polypeptide binding]; other site 1206745005022 putative CheW interface [polypeptide binding]; other site 1206745005023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1206745005024 PAS domain; Region: PAS_9; pfam13426 1206745005025 putative active site [active] 1206745005026 heme pocket [chemical binding]; other site 1206745005027 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1206745005028 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1206745005029 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1206745005030 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1206745005031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206745005032 dimer interface [polypeptide binding]; other site 1206745005033 conserved gate region; other site 1206745005034 ABC-ATPase subunit interface; other site 1206745005035 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1206745005036 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1206745005037 Walker A/P-loop; other site 1206745005038 ATP binding site [chemical binding]; other site 1206745005039 Q-loop/lid; other site 1206745005040 ABC transporter signature motif; other site 1206745005041 Walker B; other site 1206745005042 D-loop; other site 1206745005043 H-loop/switch region; other site 1206745005044 NIL domain; Region: NIL; pfam09383 1206745005045 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1206745005046 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1206745005047 active site 1206745005048 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1206745005049 Sel1-like repeats; Region: SEL1; smart00671 1206745005050 Sel1-like repeats; Region: SEL1; smart00671 1206745005051 Sel1-like repeats; Region: SEL1; smart00671 1206745005052 Sel1-like repeats; Region: SEL1; smart00671 1206745005053 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 1206745005054 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1206745005055 putative trimer interface [polypeptide binding]; other site 1206745005056 putative CoA binding site [chemical binding]; other site 1206745005057 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1206745005058 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1206745005059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206745005060 inhibitor-cofactor binding pocket; inhibition site 1206745005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745005062 catalytic residue [active] 1206745005063 YceI-like domain; Region: YceI; pfam04264 1206745005064 acetylornithine aminotransferase; Provisional; Region: PRK02627 1206745005065 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206745005066 inhibitor-cofactor binding pocket; inhibition site 1206745005067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745005068 catalytic residue [active] 1206745005069 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1206745005070 Cache domain; Region: Cache_1; pfam02743 1206745005071 HAMP domain; Region: HAMP; pfam00672 1206745005072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745005073 dimer interface [polypeptide binding]; other site 1206745005074 putative CheW interface [polypeptide binding]; other site 1206745005075 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1206745005076 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1206745005077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745005078 Walker A/P-loop; other site 1206745005079 ATP binding site [chemical binding]; other site 1206745005080 Q-loop/lid; other site 1206745005081 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1206745005082 ABC transporter signature motif; other site 1206745005083 Walker B; other site 1206745005084 D-loop; other site 1206745005085 H-loop/switch region; other site 1206745005086 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1206745005087 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1206745005088 Endonuclease I; Region: Endonuclease_1; pfam04231 1206745005089 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206745005090 HSP70 interaction site [polypeptide binding]; other site 1206745005091 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1206745005092 Isochorismatase family; Region: Isochorismatase; pfam00857 1206745005093 catalytic triad [active] 1206745005094 dimer interface [polypeptide binding]; other site 1206745005095 conserved cis-peptide bond; other site 1206745005096 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1206745005097 propionate/acetate kinase; Provisional; Region: PRK12379 1206745005098 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1206745005099 Nitrate and nitrite sensing; Region: NIT; pfam08376 1206745005100 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1206745005101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1206745005102 dimer interface [polypeptide binding]; other site 1206745005103 putative CheW interface [polypeptide binding]; other site 1206745005104 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1206745005105 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1206745005106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745005107 FeS/SAM binding site; other site 1206745005108 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 1206745005109 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1206745005110 NAD binding site [chemical binding]; other site 1206745005111 homotetramer interface [polypeptide binding]; other site 1206745005112 homodimer interface [polypeptide binding]; other site 1206745005113 substrate binding site [chemical binding]; other site 1206745005114 active site 1206745005115 triosephosphate isomerase; Provisional; Region: PRK14565 1206745005116 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1206745005117 substrate binding site [chemical binding]; other site 1206745005118 dimer interface [polypeptide binding]; other site 1206745005119 catalytic triad [active] 1206745005120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206745005121 active site 1206745005122 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 1206745005123 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1206745005124 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745005125 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745005126 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1206745005127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 1206745005128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206745005129 ATP binding site [chemical binding]; other site 1206745005130 putative Mg++ binding site [ion binding]; other site 1206745005131 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1206745005132 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1206745005133 DNA binding residues [nucleotide binding] 1206745005134 putative dimer interface [polypeptide binding]; other site 1206745005135 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1206745005136 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745005137 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745005138 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 1206745005139 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1206745005140 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1206745005141 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1206745005142 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1206745005143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206745005144 putative substrate translocation pore; other site 1206745005145 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1206745005146 CrcB-like protein; Region: CRCB; pfam02537 1206745005147 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1206745005148 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1206745005149 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1206745005150 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1206745005151 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1206745005152 Lumazine binding domain; Region: Lum_binding; pfam00677 1206745005153 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1206745005154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1206745005155 active site 1206745005156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206745005157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206745005158 catalytic residue [active] 1206745005159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206745005160 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1206745005161 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1206745005162 Sporulation related domain; Region: SPOR; pfam05036 1206745005163 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1206745005164 putative active site pocket [active] 1206745005165 4-fold oligomerization interface [polypeptide binding]; other site 1206745005166 metal binding residues [ion binding]; metal-binding site 1206745005167 3-fold/trimer interface [polypeptide binding]; other site 1206745005168 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1206745005169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206745005170 active site 1206745005171 motif I; other site 1206745005172 motif II; other site 1206745005173 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1206745005174 OstA-like protein; Region: OstA; pfam03968 1206745005175 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1206745005176 G1 box; other site 1206745005177 GTP/Mg2+ binding site [chemical binding]; other site 1206745005178 Switch I region; other site 1206745005179 G2 box; other site 1206745005180 G3 box; other site 1206745005181 Switch II region; other site 1206745005182 G4 box; other site 1206745005183 G5 box; other site 1206745005184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206745005185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206745005186 Coenzyme A binding pocket [chemical binding]; other site 1206745005187 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1206745005188 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206745005189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206745005190 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1206745005191 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1206745005192 NAD(P) binding site [chemical binding]; other site 1206745005193 homodimer interface [polypeptide binding]; other site 1206745005194 substrate binding site [chemical binding]; other site 1206745005195 active site 1206745005196 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1206745005197 Ferritin-like domain; Region: Ferritin; pfam00210 1206745005198 ferroxidase diiron center [ion binding]; other site 1206745005199 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1206745005200 Flavoprotein; Region: Flavoprotein; pfam02441 1206745005201 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1206745005202 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206745005203 FAD binding domain; Region: FAD_binding_4; pfam01565 1206745005204 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1206745005205 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1206745005206 Protein of unknown function (DUF511); Region: DUF511; cl01114 1206745005207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206745005208 non-specific DNA binding site [nucleotide binding]; other site 1206745005209 salt bridge; other site 1206745005210 sequence-specific DNA binding site [nucleotide binding]; other site 1206745005211 DNA polymerase I; Provisional; Region: PRK05755 1206745005212 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1206745005213 active site 1206745005214 metal binding site 1 [ion binding]; metal-binding site 1206745005215 putative 5' ssDNA interaction site; other site 1206745005216 metal binding site 3; metal-binding site 1206745005217 metal binding site 2 [ion binding]; metal-binding site 1206745005218 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1206745005219 putative DNA binding site [nucleotide binding]; other site 1206745005220 putative metal binding site [ion binding]; other site 1206745005221 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1206745005222 active site 1206745005223 catalytic site [active] 1206745005224 substrate binding site [chemical binding]; other site 1206745005225 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1206745005226 active site 1206745005227 DNA binding site [nucleotide binding] 1206745005228 catalytic site [active] 1206745005229 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1206745005230 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 1206745005231 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1206745005232 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1206745005233 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1206745005234 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 1206745005235 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1206745005236 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1206745005237 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 1206745005238 Low-spin heme binding site [chemical binding]; other site 1206745005239 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1206745005240 D-pathway; other site 1206745005241 Putative water exit pathway; other site 1206745005242 Binuclear center (active site) [active] 1206745005243 K-pathway; other site 1206745005244 Putative proton exit pathway; other site 1206745005245 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1206745005246 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1206745005247 Ligand Binding Site [chemical binding]; other site 1206745005248 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1206745005249 Citrate transporter; Region: CitMHS; pfam03600 1206745005250 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1206745005251 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1206745005252 Predicted permeases [General function prediction only]; Region: COG0730 1206745005253 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1206745005254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1206745005255 putative active site [active] 1206745005256 putative metal binding site [ion binding]; other site 1206745005257 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1206745005258 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1206745005259 TrkA-N domain; Region: TrkA_N; pfam02254 1206745005260 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1206745005261 ligand binding site [chemical binding]; other site 1206745005262 active site 1206745005263 UGI interface [polypeptide binding]; other site 1206745005264 catalytic site [active] 1206745005265 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1206745005266 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1206745005267 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1206745005268 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1206745005269 shikimate binding site; other site 1206745005270 NAD(P) binding site [chemical binding]; other site 1206745005271 Bacterial SH3 domain; Region: SH3_3; pfam08239 1206745005272 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1206745005273 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1206745005274 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1206745005275 dimerization interface [polypeptide binding]; other site 1206745005276 putative ATP binding site [chemical binding]; other site 1206745005277 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206745005278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206745005279 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1206745005280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206745005281 minor groove reading motif; other site 1206745005282 helix-hairpin-helix signature motif; other site 1206745005283 substrate binding pocket [chemical binding]; other site 1206745005284 active site 1206745005285 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1206745005286 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1206745005287 glutamate dehydrogenase; Provisional; Region: PRK09414 1206745005288 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1206745005289 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1206745005290 NAD(P) binding site [chemical binding]; other site 1206745005291 RecO N terminal; Region: RecO_N_2; cl15812 1206745005292 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1206745005293 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1206745005294 active site 1206745005295 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1206745005296 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1206745005297 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206745005298 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1206745005299 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1206745005300 serine O-acetyltransferase; Region: cysE; TIGR01172 1206745005301 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1206745005302 trimer interface [polypeptide binding]; other site 1206745005303 active site 1206745005304 substrate binding site [chemical binding]; other site 1206745005305 CoA binding site [chemical binding]; other site 1206745005306 arginine decarboxylase; Provisional; Region: PRK05354 1206745005307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1206745005308 dimer interface [polypeptide binding]; other site 1206745005309 active site 1206745005310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206745005311 catalytic residues [active] 1206745005312 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1206745005313 metal-binding heat shock protein; Provisional; Region: PRK00016 1206745005314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206745005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206745005316 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1206745005317 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1206745005318 DNA protecting protein DprA; Region: dprA; TIGR00732 1206745005319 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1206745005320 NodB motif; other site 1206745005321 putative active site [active] 1206745005322 putative catalytic site [active] 1206745005323 Zn binding site [ion binding]; other site 1206745005324 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1206745005325 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1206745005326 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1206745005327 P-loop; other site 1206745005328 ADP binding residues [chemical binding]; other site 1206745005329 Switch I; other site 1206745005330 Switch II; other site 1206745005331 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745005332 argininosuccinate synthase; Provisional; Region: PRK13820 1206745005333 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1206745005334 ANP binding site [chemical binding]; other site 1206745005335 Substrate Binding Site II [chemical binding]; other site 1206745005336 Substrate Binding Site I [chemical binding]; other site 1206745005337 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1206745005338 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1206745005339 Cation efflux family; Region: Cation_efflux; cl00316 1206745005340 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1206745005341 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1206745005342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206745005343 ATP binding site [chemical binding]; other site 1206745005344 putative Mg++ binding site [ion binding]; other site 1206745005345 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1206745005346 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206745005347 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206745005348 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206745005349 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1206745005350 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1206745005351 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206745005352 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206745005353 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206745005354 putative switch regulator; other site 1206745005355 non-specific DNA interactions [nucleotide binding]; other site 1206745005356 DNA binding site [nucleotide binding] 1206745005357 sequence specific DNA binding site [nucleotide binding]; other site 1206745005358 putative cAMP binding site [chemical binding]; other site 1206745005359 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1206745005360 DNA methylase; Region: N6_N4_Mtase; pfam01555 1206745005361 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1206745005362 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1206745005363 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1206745005364 gating phenylalanine in ion channel; other site 1206745005365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745005366 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1206745005367 FeS/SAM binding site; other site 1206745005368 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1206745005369 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1206745005370 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1206745005371 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1206745005372 active site 1206745005373 non-prolyl cis peptide bond; other site 1206745005374 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1206745005375 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1206745005376 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1206745005377 active site 1206745005378 dimer interface [polypeptide binding]; other site 1206745005379 non-prolyl cis peptide bond; other site 1206745005380 insertion regions; other site 1206745005381 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1206745005382 AAA domain; Region: AAA_26; pfam13500 1206745005383 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1206745005384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206745005385 inhibitor-cofactor binding pocket; inhibition site 1206745005386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206745005387 catalytic residue [active] 1206745005388 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1206745005389 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1206745005390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206745005391 catalytic residue [active] 1206745005392 Protein of unknown function (DUF452); Region: DUF452; cl01062 1206745005393 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1206745005394 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 1206745005395 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206745005396 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206745005397 catalytic residues [active] 1206745005398 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206745005399 active site 1206745005400 catalytic residues [active] 1206745005401 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1206745005402 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1206745005403 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1206745005404 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1206745005405 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1206745005406 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1206745005407 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1206745005408 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1206745005409 ring oligomerisation interface [polypeptide binding]; other site 1206745005410 ATP/Mg binding site [chemical binding]; other site 1206745005411 stacking interactions; other site 1206745005412 hinge regions; other site 1206745005413 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1206745005414 oligomerisation interface [polypeptide binding]; other site 1206745005415 mobile loop; other site 1206745005416 roof hairpin; other site 1206745005417 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1206745005418 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1206745005419 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1206745005420 Ligand Binding Site [chemical binding]; other site 1206745005421 DNA primase; Validated; Region: dnaG; PRK05667 1206745005422 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1206745005423 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1206745005424 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1206745005425 active site 1206745005426 metal binding site [ion binding]; metal-binding site 1206745005427 interdomain interaction site; other site 1206745005428 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1206745005429 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1206745005430 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1206745005431 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1206745005432 LysE type translocator; Region: LysE; cl00565 1206745005433 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1206745005434 PhnA protein; Region: PhnA; pfam03831 1206745005435 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1206745005436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1206745005437 N-terminal plug; other site 1206745005438 ligand-binding site [chemical binding]; other site 1206745005439 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1206745005440 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206745005441 active site 1206745005442 HIGH motif; other site 1206745005443 nucleotide binding site [chemical binding]; other site 1206745005444 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206745005445 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1206745005446 active site 1206745005447 KMSKS motif; other site 1206745005448 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1206745005449 tRNA binding surface [nucleotide binding]; other site 1206745005450 anticodon binding site; other site 1206745005451 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1206745005452 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1206745005453 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206745005454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206745005455 rod shape-determining protein MreC; Provisional; Region: PRK13922 1206745005456 rod shape-determining protein MreC; Region: MreC; pfam04085 1206745005457 rod shape-determining protein MreB; Provisional; Region: PRK13927 1206745005458 MreB and similar proteins; Region: MreB_like; cd10225 1206745005459 nucleotide binding site [chemical binding]; other site 1206745005460 Mg binding site [ion binding]; other site 1206745005461 putative protofilament interaction site [polypeptide binding]; other site 1206745005462 RodZ interaction site [polypeptide binding]; other site 1206745005463 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1206745005464 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1206745005465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206745005466 Walker A motif; other site 1206745005467 ATP binding site [chemical binding]; other site 1206745005468 Walker B motif; other site 1206745005469 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1206745005470 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1206745005471 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1206745005472 active site 1206745005473 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1206745005474 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 1206745005475 Ligand Binding Site [chemical binding]; other site 1206745005476 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 1206745005477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206745005478 FeS/SAM binding site; other site 1206745005479 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1206745005480 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1206745005481 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1206745005482 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1206745005483 substrate binding site [chemical binding]; other site 1206745005484 glutamase interaction surface [polypeptide binding]; other site 1206745005485 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1206745005486 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1206745005487 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1206745005488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1206745005489 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1206745005490 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1206745005491 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1206745005492 putative active site [active] 1206745005493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1206745005494 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 1206745005495 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1206745005496 catalytic center binding site [active] 1206745005497 ATP binding site [chemical binding]; other site 1206745005498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206745005499 2-isopropylmalate synthase; Validated; Region: PRK03739 1206745005500 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1206745005501 active site 1206745005502 catalytic residues [active] 1206745005503 metal binding site [ion binding]; metal-binding site 1206745005504 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1206745005505 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1206745005506 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1206745005507 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1206745005508 substrate binding site [chemical binding]; other site 1206745005509 ligand binding site [chemical binding]; other site 1206745005510 3-isopropylmalate dehydratase, small subunit; Region: leud; TIGR02084 1206745005511 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1206745005512 substrate binding site [chemical binding]; other site 1206745005513 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1206745005514 tartrate dehydrogenase; Region: TTC; TIGR02089 1206745005515 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1206745005516 putative active site [active] 1206745005517 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1206745005518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206745005519 Mg2+ binding site [ion binding]; other site 1206745005520 G-X-G motif; other site 1206745005521 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1206745005522 anchoring element; other site 1206745005523 dimer interface [polypeptide binding]; other site 1206745005524 ATP binding site [chemical binding]; other site 1206745005525 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1206745005526 active site 1206745005527 putative metal-binding site [ion binding]; other site 1206745005528 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1206745005529 DNA polymerase III subunit beta; Validated; Region: PRK05643 1206745005530 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1206745005531 putative DNA binding surface [nucleotide binding]; other site 1206745005532 dimer interface [polypeptide binding]; other site 1206745005533 beta-clamp/clamp loader binding surface; other site 1206745005534 beta-clamp/translesion DNA polymerase binding surface; other site 1206745005535 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206745005536 Permease; Region: Permease; cl00510 1206745005537 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1206745005538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206745005539 Walker A/P-loop; other site 1206745005540 ATP binding site [chemical binding]; other site 1206745005541 Q-loop/lid; other site 1206745005542 ABC transporter signature motif; other site 1206745005543 Walker B; other site 1206745005544 D-loop; other site 1206745005545 H-loop/switch region; other site 1206745005546 mce related protein; Region: MCE; pfam02470 1206745005547 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1206745005548 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 1206745005549 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1206745005550 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1206745005551 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1206745005552 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1206745005553 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206745005554 Walker A motif; other site 1206745005555 ATP binding site [chemical binding]; other site 1206745005556 Walker B motif; other site 1206745005557 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1206745005558 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1206745005559 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1206745005560 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1206745005561 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1206745005562 active site 1206745005563 putative DNA-binding cleft [nucleotide binding]; other site 1206745005564 dimer interface [polypeptide binding]; other site