-- dump date 20140619_112314 -- class Genbank::misc_feature -- table misc_feature_note -- id note 936155000001 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000002 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000003 1 probable transmembrane helix predicted for Hfelis16780 by TMHMM2.0 at aa 20-42 936155000004 HMMPfam hit to PF08238, Sel1, score 8.7e-06 936155000005 Integrase core domain; Region: rve; pfam00665 936155000006 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 936155000007 HMMPfam hit to PF00665, rve, score 3.2e-17 936155000008 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 936155000009 Pleckstrin homology-like domain; Region: PH-like; cl17171 936155000010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936155000011 Predicted helix-turn-helix motif with score 1559.000, SD 4.50 at aa 5-37, sequence KELEAFISEFGLSQAQVARSINKSPALISSYIK 936155000012 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000013 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 936155000014 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 936155000015 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 936155000016 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000017 HMMPfam hit to PF07282, Transposase_35, score 5.8e-05 936155000018 Protein of unknown function (DUF935); Region: DUF935; pfam06074 936155000019 PS00636 Nt-dnaJ domain signature 936155000020 Terminase-like family; Region: Terminase_6; pfam03237 936155000021 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 936155000022 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 936155000023 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 936155000024 triacylglycerol lipase; Region: PLN02324 936155000025 Homeodomain-like domain; Region: HTH_23; cl17451 936155000026 Predicted helix-turn-helix motif with score 1186.000, SD 3.23 at aa 29-50, sequence KSYEYICQTLNITKNTINSHRK 936155000027 1 probable transmembrane helix predicted for Hfelis00520 by TMHMM2.0 at aa 66-88 936155000028 1 probable transmembrane helix predicted for Hfelis00530 by TMHMM2.0 at aa 7-29 936155000029 3 probable transmembrane helices predicted for Hfelis00540 by TMHMM2.0 at aa 15-34, 53-75 and 79-98 936155000030 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 936155000031 1 probable transmembrane helix predicted for Hfelis00550 by TMHMM2.0 at aa 22-44 936155000032 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936155000033 amidase catalytic site [active] 936155000034 Zn binding residues [ion binding]; other site 936155000035 substrate binding site [chemical binding]; other site 936155000036 HMMPfam hit to PF01510, Amidase_2, score 3.7e-07 936155000037 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 936155000038 HMMPfam hit to PF10123, Mu-like_Pro, score 1.1e-09 936155000039 2 probable transmembrane helices predicted for Hfelis00610 by TMHMM2.0 at aa 856-878 and 899-921 936155000040 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 936155000041 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 936155000042 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 936155000043 HMMPfam hit to PF10124, Mu-like_gpT, score 1.8e-23 936155000044 HMMPfam hit to PF10124, Mu-like_gpT, score 3.5e-18 936155000045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 936155000046 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 936155000047 Probable transposase; Region: OrfB_IS605; pfam01385 936155000048 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 936155000049 HMMPfam hit to PF07282, Transposase_35, score 3.1e-29 936155000050 HMMPfam hit to PF01385, Transposase_2, score 2.8e-109 936155000051 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000052 HMMPfam hit to PF08238, Sel1, score 0.00014 936155000053 HMMPfam hit to PF08238, Sel1, score 0.00023 936155000054 HMMPfam hit to PF08238, Sel1, score 0.00069 936155000055 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000057 binding surface 936155000058 TPR motif; other site 936155000059 Sel1-like repeats; Region: SEL1; smart00671 936155000060 Sel1-like repeats; Region: SEL1; smart00671 936155000061 HMMPfam hit to PF08238, Sel1, score 1.2e-09 936155000062 HMMPfam hit to PF08238, Sel1, score 0.00037 936155000063 HMMPfam hit to PF08238, Sel1, score 1.6e-05 936155000064 HMMPfam hit to PF08238, Sel1, score 1.5e-09 936155000065 HMMPfam hit to PF08238, Sel1, score 2.8e-07 936155000066 HMMPfam hit to PF08238, Sel1, score 0.00012 936155000067 HMMPfam hit to PF08238, Sel1, score 1.3e-08 936155000068 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 936155000069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000070 1 probable transmembrane helix predicted for Hfelis00700 by TMHMM2.0 at aa 7-29 936155000071 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000072 3 probable transmembrane helices predicted for Hfelis00770 by TMHMM2.0 at aa 5-27, 37-54 and 61-83 936155000073 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000074 3 probable transmembrane helices predicted for Hfelis00780 by TMHMM2.0 at aa 7-29, 39-58 and 70-92 936155000075 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000076 3 probable transmembrane helices predicted for Hfelis00790 by TMHMM2.0 at aa 7-29, 39-56 and 68-90 936155000077 2 probable transmembrane helices predicted for Hfelis00800 by TMHMM2.0 at aa 20-42 and 54-76 936155000078 3 probable transmembrane helices predicted for Hfelis00810 by TMHMM2.0 at aa 12-34, 44-61 and 68-90 936155000079 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000080 3 probable transmembrane helices predicted for Hfelis00820 by TMHMM2.0 at aa 12-34, 38-55 and 67-89 936155000081 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000082 4 probable transmembrane helices predicted for Hfelis00830 by TMHMM2.0 at aa 4-26, 47-69, 79-98 and 111-133 936155000083 4 probable transmembrane helices predicted for Hfelis00850 by TMHMM2.0 at aa 9-26, 36-58, 63-82 and 86-103 936155000084 3 probable transmembrane helices predicted for Hfelis00870 by TMHMM2.0 at aa 7-29, 33-55 and 76-98 936155000085 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000086 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000087 Sel1 repeat; Region: Sel1; cl02723 936155000088 HMMPfam hit to PF08238, Sel1, score 0.00043 936155000089 HMMPfam hit to PF08238, Sel1, score 8.2e-10 936155000090 HMMPfam hit to PF08238, Sel1, score 9.9e-08 936155000091 HMMPfam hit to PF08238, Sel1, score 0.026 936155000092 HMMPfam hit to PF08238, Sel1, score 7.8e-06 936155000093 HMMPfam hit to PF08238, Sel1, score 0.0027 936155000094 HMMPfam hit to PF07690, MFS_1, score 1.6e-23 936155000095 12 probable transmembrane helices predicted for Hfelis00950 by TMHMM2.0 at aa 5-24, 29-48, 61-83, 87-109, 116-138, 143-165, 185-207, 227-249, 254-276, 280-302, 311-333 and 337-359 936155000096 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000097 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000098 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000099 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 936155000100 HMMPfam hit to PF01197, Ribosomal_L31, score 5.9e-43 936155000101 PS01143 Ribosomal protein L31 signature 936155000102 Predicted methyltransferases [General function prediction only]; Region: COG0313 936155000103 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 936155000104 putative SAM binding site [chemical binding]; other site 936155000105 putative homodimer interface [polypeptide binding]; other site 936155000106 HMMPfam hit to PF00590, TP_methylase, score 2.9e-17 936155000107 PS01296 Uncharacterized protein family UPF0011 signature 936155000108 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 936155000109 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 936155000110 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936155000111 HMMPfam hit to PF08032, SpoU_sub_bind, score 4.4e-06 936155000112 HMMPfam hit to PF00588, SpoU_methylase, score 3e-40 936155000113 1 probable transmembrane helix predicted for Hfelis00990 by TMHMM2.0 at aa 123-140 936155000114 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 936155000115 YceI-like domain; Region: YceI; cl01001 936155000116 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 936155000117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936155000118 inhibitor-cofactor binding pocket; inhibition site 936155000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155000120 catalytic residue [active] 936155000121 HMMPfam hit to PF00202, Aminotran_3, score 3.4e-74 936155000122 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site 936155000123 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000124 2 probable transmembrane helices predicted for Hfelis01030 by TMHMM2.0 at aa 13-35 and 40-62 936155000125 4 probable transmembrane helices predicted for Hfelis01040 by TMHMM2.0 at aa 7-26, 30-48, 69-91 and 101-120 936155000126 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155000127 HMMPfam hit to PF01856, HP_OMP, score 1.1e-42 936155000128 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 936155000129 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 936155000130 metal binding site [ion binding]; metal-binding site 936155000131 putative dimer interface [polypeptide binding]; other site 936155000132 HMMPfam hit to PF01546, Peptidase_M20, score 1.7e-48 936155000133 HMMPfam hit to PF07687, M20_dimer, score 2.5e-09 936155000134 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 936155000135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155000136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155000137 dimer interface [polypeptide binding]; other site 936155000138 putative CheW interface [polypeptide binding]; other site 936155000139 HMMPfam hit to PF00015, MCPsignal, score 1.5e-29 936155000140 1 probable transmembrane helix predicted for Hfelis01080 by TMHMM2.0 at aa 196-218 936155000141 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 936155000142 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 936155000143 dimerization interface [polypeptide binding]; other site 936155000144 HMMPfam hit to PF02618, ADC_lyase, score 4.9e-49 936155000145 1 probable transmembrane helix predicted for Hfelis01090 by TMHMM2.0 at aa 26-45 936155000146 Protein of unknown function; Region: DUF3971; pfam13116 936155000147 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 936155000148 PS00107 Protein kinases ATP-binding region signature 936155000149 FeoA domain; Region: FeoA; pfam04023 936155000150 HMMPfam hit to PF04023, FeoA, score 6.1e-11 936155000151 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 936155000152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936155000153 minor groove reading motif; other site 936155000154 helix-hairpin-helix signature motif; other site 936155000155 substrate binding pocket [chemical binding]; other site 936155000156 active site 936155000157 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 936155000158 HMMPfam hit to PF00730, HhH-GPD, score 4e-23 936155000159 HMMPfam hit to PF10576, EndIII_4Fe-2S, score 0.00019 936155000160 flagellar motor switch protein; Validated; Region: PRK08433 936155000161 HMMPfam hit to PF01052, SpoA, score 4.4e-24 936155000162 2 probable transmembrane helices predicted for Hfelis01140 by TMHMM2.0 at aa 20-39 and 164-186 936155000163 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 936155000164 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 936155000165 1 probable transmembrane helix predicted for Hfelis01150 by TMHMM2.0 at aa 21-43 936155000166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936155000167 active site 936155000168 HMMPfam hit to PF04909, Amidohydro_2, score 1.7e-05 936155000169 PS00482 Dihydroorotase signature 1 936155000170 PS00483 Dihydroorotase signature 2 936155000171 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 936155000172 BNR repeat-like domain; Region: BNR_2; pfam13088 936155000173 1 probable transmembrane helix predicted for Hfelis01170 by TMHMM2.0 at aa 5-23 936155000174 PS00120 Lipases, serine active site 936155000175 5 probable transmembrane helices predicted for Hfelis01180 by TMHMM2.0 at aa 4-20, 25-47, 57-79, 92-114 and 124-146 936155000176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000177 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 936155000178 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 936155000179 Walker A motif; other site 936155000180 hexamer interface [polypeptide binding]; other site 936155000181 ATP binding site [chemical binding]; other site 936155000182 Walker B motif; other site 936155000183 HMMPfam hit to PF00437, GSPII_E, score 3.9e-27 936155000184 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000185 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 936155000186 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 936155000187 Ligand binding site; other site 936155000188 oligomer interface; other site 936155000189 HMMPfam hit to PF02348, CTP_transf_3, score 1.1e-49 936155000190 Uncharacterized conserved protein [Function unknown]; Region: COG1565 936155000191 HMMPfam hit to PF02636, DUF185, score 4.7e-05 936155000192 heat shock protein 90; Provisional; Region: PRK05218 936155000193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155000194 ATP binding site [chemical binding]; other site 936155000195 Mg2+ binding site [ion binding]; other site 936155000196 G-X-G motif; other site 936155000197 HMMPfam hit to PF00183, HSP90, score 8.7e-82 936155000198 HMMPfam hit to PF02518, HATPase_c, score 5.2e-12 936155000199 PS00298 Heat shock hsp90 proteins family signature 936155000200 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 936155000201 active site 936155000202 substrate binding site [chemical binding]; other site 936155000203 cosubstrate binding site; other site 936155000204 catalytic site [active] 936155000205 HMMPfam hit to PF00551, Formyl_trans_N, score 6.1e-26 936155000206 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 936155000207 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 936155000208 12 probable transmembrane helices predicted for Hfelis01250 by TMHMM2.0 at aa 4-23, 28-47, 57-74, 81-103, 107-126, 138-160, 175-197, 222-244, 264-286, 293-315, 325-347 and 354-376 936155000209 HMMPfam hit to PF00999, Na_H_Exchanger, score 3.1e-39 936155000210 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000211 Sel1-like repeats; Region: SEL1; smart00671 936155000212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000213 TPR motif; other site 936155000214 binding surface 936155000215 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155000216 Sel1-like repeats; Region: SEL1; smart00671 936155000217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000218 binding surface 936155000219 TPR motif; other site 936155000220 HMMPfam hit to PF08238, Sel1, score 6.2e-06 936155000221 HMMPfam hit to PF08238, Sel1, score 1.1e-07 936155000222 HMMPfam hit to PF08238, Sel1, score 1.8e-08 936155000223 HMMPfam hit to PF08238, Sel1, score 1e-07 936155000224 HMMPfam hit to PF08238, Sel1, score 1e-08 936155000225 HMMPfam hit to PF08238, Sel1, score 2.7e-09 936155000226 HMMPfam hit to PF08238, Sel1, score 0.0005 936155000227 HMMPfam hit to PF08238, Sel1, score 9.4e-08 936155000228 HMMPfam hit to PF08238, Sel1, score 0.0023 936155000229 Uncharacterized conserved protein [Function unknown]; Region: COG2353 936155000230 HMMPfam hit to PF04264, YceI, score 1.9e-43 936155000231 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 936155000232 Part of AAA domain; Region: AAA_19; pfam13245 936155000233 Family description; Region: UvrD_C_2; pfam13538 936155000234 HMMPfam hit to PF00580, UvrD-helicase, score 1.3e-83 936155000235 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 936155000237 PAS domain; Region: PAS_9; pfam13426 936155000238 putative active site [active] 936155000239 heme pocket [chemical binding]; other site 936155000240 HMMPfam hit to PF08447, PAS_3, score 1.2e-05 936155000241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155000242 dimer interface [polypeptide binding]; other site 936155000243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155000244 putative CheW interface [polypeptide binding]; other site 936155000245 HMMPfam hit to PF00015, MCPsignal, score 1.7e-27 936155000246 Protein of unknown function (DUF541); Region: SIMPL; cl01077 936155000247 1 probable transmembrane helix predicted for Hfelis01320 by TMHMM2.0 at aa 7-29 936155000248 aspartate aminotransferase; Provisional; Region: PRK05764 936155000249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936155000250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155000251 homodimer interface [polypeptide binding]; other site 936155000252 catalytic residue [active] 936155000253 HMMPfam hit to PF00155, Aminotran_1_2, score 8.3e-90 936155000254 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site 936155000255 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155000256 HMMPfam hit to PF01856, HP_OMP, score 6.9e-52 936155000257 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 936155000258 HMMPfam hit to PF09982, DUF2219, score 1.7e-74 936155000259 1 probable transmembrane helix predicted for Hfelis01360 by TMHMM2.0 at aa 3-20 936155000260 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 936155000261 HMMPfam hit to PF01219, DAGK_prokar, score 2.3e-26 936155000262 2 probable transmembrane helices predicted for Hfelis01370 by TMHMM2.0 at aa 28-50 and 92-111 936155000263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000264 PS01069 Prokaryotic diacylglycerol kinase signature 936155000265 DNA gyrase subunit A; Validated; Region: PRK05560 936155000266 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 936155000267 CAP-like domain; other site 936155000268 active site 936155000269 primary dimer interface [polypeptide binding]; other site 936155000270 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936155000271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936155000272 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936155000273 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936155000274 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936155000275 HMMPfam hit to PF00521, DNA_topoisoIV, score 1e-293 936155000276 HMMPfam hit to PF03989, DNA_gyraseA_C, score 2.7e-14 936155000277 HMMPfam hit to PF03989, DNA_gyraseA_C, score 4e-12 936155000278 HMMPfam hit to PF03989, DNA_gyraseA_C, score 3.8e-10 936155000279 HMMPfam hit to PF03989, DNA_gyraseA_C, score 3.1e-15 936155000280 HMMPfam hit to PF03989, DNA_gyraseA_C, score 7.3e-12 936155000281 HMMPfam hit to PF03989, DNA_gyraseA_C, score 3.2e-12 936155000282 Response regulator receiver domain; Region: Response_reg; pfam00072 936155000283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155000284 active site 936155000285 phosphorylation site [posttranslational modification] 936155000286 intermolecular recognition site; other site 936155000287 dimerization interface [polypeptide binding]; other site 936155000288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155000289 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936155000290 Walker A motif; other site 936155000291 ATP binding site [chemical binding]; other site 936155000292 Walker B motif; other site 936155000293 arginine finger; other site 936155000294 HMMPfam hit to PF00072, Response_reg, score 1e-26 936155000295 HMMPfam hit to PF00158, Sigma54_activat, score 7e-143 936155000296 PS00676 Sigma-54 interaction domain ATP-binding region B signature 936155000297 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936155000298 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936155000299 dimer interface [polypeptide binding]; other site 936155000300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155000301 catalytic residue [active] 936155000302 HMMPfam hit to PF00291, PALP, score 3.1e-117 936155000303 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site 936155000304 serine O-acetyltransferase; Region: cysE; TIGR01172 936155000305 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 936155000306 trimer interface [polypeptide binding]; other site 936155000307 active site 936155000308 substrate binding site [chemical binding]; other site 936155000309 CoA binding site [chemical binding]; other site 936155000310 HMMPfam hit to PF00132, Hexapep, score 18 936155000311 HMMPfam hit to PF00132, Hexapep, score 0.02 936155000312 HMMPfam hit to PF00132, Hexapep, score 16 936155000313 PS00101 Hexapeptide-repeat containing-transferases signature 936155000314 HMMPfam hit to PF00132, Hexapep, score 5.1 936155000315 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 936155000316 dimerization interface [polypeptide binding]; other site 936155000317 putative ATP binding site [chemical binding]; other site 936155000318 HMMPfam hit to PF00586, AIRS, score 4.7e-22 936155000319 HMMPfam hit to PF02769, AIRS_C, score 9.7e-17 936155000320 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 936155000321 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 936155000322 Ligand Binding Site [chemical binding]; other site 936155000323 HMMPfam hit to PF06508, ExsB, score 3.1e-07 936155000324 DNA primase; Validated; Region: dnaG; PRK05667 936155000325 CHC2 zinc finger; Region: zf-CHC2; pfam01807 936155000326 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 936155000327 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 936155000328 active site 936155000329 metal binding site [ion binding]; metal-binding site 936155000330 interdomain interaction site; other site 936155000331 HMMPfam hit to PF01751, Toprim, score 1.2e-16 936155000332 HMMPfam hit to PF08275, Toprim_N, score 1.3e-42 936155000333 HMMPfam hit to PF01807, zf-CHC2, score 2.1e-49 936155000334 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 936155000335 oligomerisation interface [polypeptide binding]; other site 936155000336 mobile loop; other site 936155000337 roof hairpin; other site 936155000338 HMMPfam hit to PF00166, Cpn10, score 3e-37 936155000339 PS00681 Chaperonins cpn10 signature 936155000340 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 936155000341 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 936155000342 ring oligomerisation interface [polypeptide binding]; other site 936155000343 ATP/Mg binding site [chemical binding]; other site 936155000344 stacking interactions; other site 936155000345 hinge regions; other site 936155000346 HMMPfam hit to PF00118, Cpn60_TCP1, score 3.5e-188 936155000347 PS00296 Chaperonins cpn60 signature 936155000348 1 probable transmembrane helix predicted for Hfelis01500 by TMHMM2.0 at aa 7-29 936155000349 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155000350 HMMPfam hit to PF01856, HP_OMP, score 2.6e-37 936155000351 1 probable transmembrane helix predicted for Hfelis01520 by TMHMM2.0 at aa 35-57 936155000352 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000353 Cytochrome c [Energy production and conversion]; Region: COG3258 936155000354 Cytochrome c; Region: Cytochrom_C; pfam00034 936155000355 HMMPfam hit to PF00034, Cytochrom_C, score 2.8e-06 936155000356 Protein of unknown function (DUF535); Region: DUF535; cl01128 936155000357 HMMPfam hit to PF04393, DUF535, score 4.3e-16 936155000358 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 936155000359 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 936155000360 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 936155000361 HMMPfam hit to PF00037, Fer4, score 3.6e-05 936155000362 HMMPfam hit to PF00037, Fer4, score 6.7e-08 936155000363 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155000364 HMMPfam hit to PF00037, Fer4, score 0.00034 936155000365 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155000366 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155000367 HMMPfam hit to PF04879, Molybdop_Fe4S4, score 3.9e-08 936155000368 HMMPfam hit to PF00384, Molybdopterin, score 6.6e-11 936155000369 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155000370 molybdopterin cofactor binding site; other site 936155000371 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 936155000372 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 936155000373 molybdopterin cofactor binding site; other site 936155000374 HMMPfam hit to PF00384, Molybdopterin, score 7.3e-23 936155000375 HMMPfam hit to PF00384, Molybdopterin, score 6.9e-07 936155000376 HMMPfam hit to PF01568, Molydop_binding, score 1.9e-17 936155000377 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936155000378 HMMPfam hit to PF00037, Fer4, score 6.6e-09 936155000379 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155000380 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 936155000381 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 936155000382 5 probable transmembrane helices predicted for Hfelis01620 by TMHMM2.0 at aa 51-73, 94-116, 129-151, 190-212 and 235-257 936155000383 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 936155000384 active site 1 [active] 936155000385 dimer interface [polypeptide binding]; other site 936155000386 hexamer interface [polypeptide binding]; other site 936155000387 active site 2 [active] 936155000388 HMMPfam hit to PF01361, Tautomerase, score 2.2e-16 936155000389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 936155000390 HMMPfam hit to PF04325, DUF465, score 1.2e-11 936155000391 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936155000392 HSP70 interaction site [polypeptide binding]; other site 936155000393 HMMPfam hit to PF00226, DnaJ, score 1.4e-10 936155000394 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936155000395 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 936155000396 12 probable transmembrane helices predicted for Hfelis01670 by TMHMM2.0 at aa 13-32, 47-69, 89-111, 126-148, 161-183, 193-215, 236-258, 268-290, 310-332, 359-381, 388-410 and 414-436 936155000397 HMMPfam hit to PF01554, MatE, score 5.7e-21 936155000398 HMMPfam hit to PF01554, MatE, score 1.1e-31 936155000399 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 936155000400 HMMPfam hit to PF00380, Ribosomal_S9, score 2.7e-43 936155000401 PS00360 Ribosomal protein S9 signature 936155000402 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 936155000403 23S rRNA interface [nucleotide binding]; other site 936155000404 L3 interface [polypeptide binding]; other site 936155000405 HMMPfam hit to PF00572, Ribosomal_L13, score 2.9e-56 936155000406 PS00783 Ribosomal protein L13 signature 936155000407 DNA polymerase I; Provisional; Region: PRK05755 936155000408 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 936155000409 active site 936155000410 metal binding site 1 [ion binding]; metal-binding site 936155000411 putative 5' ssDNA interaction site; other site 936155000412 metal binding site 3; metal-binding site 936155000413 metal binding site 2 [ion binding]; metal-binding site 936155000414 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 936155000415 putative DNA binding site [nucleotide binding]; other site 936155000416 putative metal binding site [ion binding]; other site 936155000417 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 936155000418 active site 936155000419 DNA binding site [nucleotide binding] 936155000420 catalytic site [active] 936155000421 HMMPfam hit to PF00476, DNA_pol_A, score 1.2e-90 936155000422 PS00447 DNA polymerase family A signature 936155000423 HMMPfam hit to PF01367, 5_3_exonuc, score 6.3e-26 936155000424 HMMPfam hit to PF02739, 5_3_exonuc_N, score 7.1e-34 936155000425 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 936155000426 HMMPfam hit to PF02511, Thy1, score 3.1e-53 936155000427 DDE superfamily endonuclease; Region: DDE_5; cl17874 936155000428 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 936155000429 Aspartase; Region: Aspartase; cd01357 936155000430 active sites [active] 936155000431 tetramer interface [polypeptide binding]; other site 936155000432 HMMPfam hit to PF10415, FumaraseC_C, score 2.2e-32 936155000433 HMMPfam hit to PF00206, Lyase_1, score 9e-148 936155000434 PS00163 Fumarate lyases signature 936155000435 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 936155000436 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 936155000437 14 probable transmembrane helices predicted for Hfelis01750 by TMHMM2.0 at aa 5-27, 47-69, 81-103, 309-331, 338-360, 636-658, 671-693, 708-725, 732-754, 769-791, 812-834, 849-866, 873-895 and 910-929 936155000438 HMMPfam hit to PF01578, Cytochrom_C_asm, score 4.6e-50 936155000439 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 936155000440 catalytic residues [active] 936155000441 ferrochelatase; Reviewed; Region: hemH; PRK00035 936155000442 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 936155000443 C-terminal domain interface [polypeptide binding]; other site 936155000444 active site 936155000445 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 936155000446 active site 936155000447 N-terminal domain interface [polypeptide binding]; other site 936155000448 HMMPfam hit to PF00762, Ferrochelatase, score 2.6e-111 936155000449 RNA methyltransferase, RsmE family; Region: TIGR00046 936155000450 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 936155000451 HMMPfam hit to PF04452, Methyltrans_RNA, score 1.1e-27 936155000452 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 936155000453 13 probable transmembrane helices predicted for Hfelis01790 by TMHMM2.0 at aa 20-42, 52-74, 81-100, 105-127, 134-156, 171-190, 195-214, 244-266, 278-300, 315-337, 344-366, 381-403 and 416-433 936155000454 HMMPfam hit to PF00860, Xan_ur_permease, score 9.3e-39 936155000455 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000456 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 936155000457 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 936155000458 HMMPfam hit to PF01171, ATP_bind_3, score 8.6e-62 936155000459 metal-binding heat shock protein; Provisional; Region: PRK00016 936155000460 HMMPfam hit to PF02130, UPF0054, score 2.3e-31 936155000461 PS01306 Uncharacterized protein family UPF0054 signature 936155000462 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000463 1 probable transmembrane helix predicted for Hfelis01830 by TMHMM2.0 at aa 5-27 936155000464 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 936155000465 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 936155000466 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 936155000467 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 936155000468 nucleotide binding site [chemical binding]; other site 936155000469 NEF interaction site [polypeptide binding]; other site 936155000470 SBD interface [polypeptide binding]; other site 936155000471 HMMPfam hit to PF00012, HSP70, score 0 936155000472 PS01036 Heat shock hsp70 proteins family signature 3 936155000473 PS00329 Heat shock hsp70 proteins family signature 2 936155000474 PS00297 Heat shock hsp70 proteins family signature 1 936155000475 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 936155000476 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 936155000477 dimer interface [polypeptide binding]; other site 936155000478 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 936155000479 HMMPfam hit to PF01025, GrpE, score 3.1e-58 936155000480 PS01071 grpE protein signature 936155000481 heat-inducible transcription repressor; Provisional; Region: PRK03911 936155000482 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 936155000483 Isochorismatase family; Region: Isochorismatase; pfam00857 936155000484 catalytic triad [active] 936155000485 conserved cis-peptide bond; other site 936155000486 HMMPfam hit to PF00857, Isochorismatase, score 0.0047 936155000487 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 936155000488 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 936155000489 dimerization interface 3.5A [polypeptide binding]; other site 936155000490 active site 936155000491 HMMPfam hit to PF01416, PseudoU_synth_1, score 6.3e-18 936155000492 HMMPfam hit to PF01416, PseudoU_synth_1, score 1.5e-21 936155000493 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 936155000494 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 936155000495 HMMPfam hit to PF03739, YjgP_YjgQ, score 8.3e-40 936155000496 6 probable transmembrane helices predicted for Hfelis01900 by TMHMM2.0 at aa 19-41, 56-78, 99-121, 268-290, 297-316 and 320-342 936155000497 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000498 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 936155000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155000500 S-adenosylmethionine binding site [chemical binding]; other site 936155000501 HMMPfam hit to PF01135, PCMT, score 3.2e-69 936155000502 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature 936155000503 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 936155000504 dimer interface [polypeptide binding]; other site 936155000505 putative radical transfer pathway; other site 936155000506 diiron center [ion binding]; other site 936155000507 tyrosyl radical; other site 936155000508 HMMPfam hit to PF00268, Ribonuc_red_sm, score 5.8e-23 936155000509 PS00368 Ribonucleotide reductase small subunit signature 936155000510 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936155000511 DNA glycosylase MutY; Provisional; Region: PRK13910 936155000512 minor groove reading motif; other site 936155000513 helix-hairpin-helix signature motif; other site 936155000514 substrate binding pocket [chemical binding]; other site 936155000515 active site 936155000516 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 936155000517 DNA binding and oxoG recognition site [nucleotide binding] 936155000518 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000519 HMMPfam hit to PF00730, HhH-GPD, score 4.9e-14 936155000520 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 936155000521 HMMPfam hit to PF01755, Glyco_transf_25, score 2.5e-46 936155000522 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936155000523 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 936155000524 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 936155000525 HMMPfam hit to PF02885, Glycos_trans_3N, score 3.4e-13 936155000526 HMMPfam hit to PF00591, Glycos_transf_3, score 9.5e-104 936155000527 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 936155000528 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 936155000529 active site 936155000530 ribulose/triose binding site [chemical binding]; other site 936155000531 phosphate binding site [ion binding]; other site 936155000532 substrate (anthranilate) binding pocket [chemical binding]; other site 936155000533 product (indole) binding pocket [chemical binding]; other site 936155000534 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 936155000535 active site 936155000536 HMMPfam hit to PF00218, IGPS, score 3.7e-117 936155000537 HMMPfam hit to PF00697, PRAI, score 4.6e-51 936155000538 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 936155000539 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 936155000540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155000541 catalytic residue [active] 936155000542 HMMPfam hit to PF00291, PALP, score 3.5e-123 936155000543 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site 936155000544 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000545 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 936155000546 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 936155000547 HMMPfam hit to PF09647, Hp0062, score 4.9e-18 936155000548 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 936155000549 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 936155000550 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 936155000551 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936155000552 HMMPfam hit to PF01580, FtsK_SpoIIIE, score 1.5e-30 936155000553 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000554 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155000555 HMMPfam hit to PF01856, HP_OMP, score 3e-51 936155000556 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 936155000557 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 936155000558 HMMPfam hit to PF02086, MethyltransfD12, score 6.2e-61 936155000559 PS00092 N-6 Adenine-specific DNA methylases signature 936155000560 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 936155000561 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 936155000562 substrate binding site [chemical binding]; other site 936155000563 active site 936155000564 catalytic residues [active] 936155000565 heterodimer interface [polypeptide binding]; other site 936155000566 HMMPfam hit to PF00290, Trp_syntA, score 3.6e-103 936155000567 PS00167 Tryptophan synthase alpha chain signature 936155000568 META domain; Region: META; cl01245 936155000569 1 probable transmembrane helix predicted for Hfelis02110 by TMHMM2.0 at aa 15-37 936155000570 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000571 HMMPfam hit to PF03724, META, score 6.9e-07 936155000572 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 936155000573 HMMPfam hit to PF01205, UPF0029, score 9.6e-15 936155000574 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 936155000575 HMMPfam hit to PF03653, UPF0093, score 1.5e-60 936155000576 4 probable transmembrane helices predicted for Hfelis02130 by TMHMM2.0 at aa 10-32, 53-75, 80-102 and 122-144 936155000577 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 936155000578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155000579 S-adenosylmethionine binding site [chemical binding]; other site 936155000580 HMMPfam hit to PF01209, Ubie_methyltran, score 5.7e-20 936155000581 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936155000582 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 936155000583 active site 936155000584 catalytic triad [active] 936155000585 dimer interface [polypeptide binding]; other site 936155000586 seryl-tRNA synthetase; Provisional; Region: PRK05431 936155000587 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 936155000588 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 936155000589 dimer interface [polypeptide binding]; other site 936155000590 active site 936155000591 motif 1; other site 936155000592 motif 2; other site 936155000593 motif 3; other site 936155000594 HMMPfam hit to PF02403, Seryl_tRNA_N, score 2.2e-13 936155000595 HMMPfam hit to PF00587, tRNA-synt_2b, score 2.4e-62 936155000596 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155000597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000598 binding surface 936155000599 TPR motif; other site 936155000600 Tetratricopeptide repeat; Region: TPR_16; pfam13432 936155000601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000602 TPR repeat; Region: TPR_11; pfam13414 936155000603 binding surface 936155000604 TPR motif; other site 936155000605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155000606 TPR motif; other site 936155000607 binding surface 936155000608 1 probable transmembrane helix predicted for Hfelis02170 by TMHMM2.0 at aa 47-69 936155000609 HMMPfam hit to PF00515, TPR_1, score 0.037 936155000610 HMMPfam hit to PF00515, TPR_1, score 0.001 936155000611 HMMPfam hit to PF00515, TPR_1, score 1.6e-06 936155000612 HMMPfam hit to PF00515, TPR_1, score 0.0072 936155000613 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 936155000614 Part of AAA domain; Region: AAA_19; pfam13245 936155000615 Family description; Region: UvrD_C_2; pfam13538 936155000616 HMMPfam hit to PF00580, UvrD-helicase, score 9e-147 936155000617 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000618 PS00881 Protein splicing signature 936155000619 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 936155000620 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 936155000621 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 936155000622 Flavoprotein; Region: Flavoprotein; pfam02441 936155000623 HMMPfam hit to PF02441, Flavoprotein, score 3.2e-41 936155000624 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 936155000625 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 936155000626 active site 936155000627 (T/H)XGH motif; other site 936155000628 HMMPfam hit to PF01467, CTP_transf_2, score 2.7e-32 936155000629 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 936155000630 thymidylate kinase; Validated; Region: tmk; PRK00698 936155000631 TMP-binding site; other site 936155000632 ATP-binding site [chemical binding]; other site 936155000633 HMMPfam hit to PF02223, Thymidylate_kin, score 1.8e-34 936155000634 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000635 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 936155000636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155000637 active site 936155000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155000639 Response regulator receiver domain; Region: Response_reg; pfam00072 936155000640 active site 936155000641 phosphorylation site [posttranslational modification] 936155000642 dimerization interface [polypeptide binding]; other site 936155000643 HMMPfam hit to PF02954, HTH_8, score 0.00012 936155000644 Predicted helix-turn-helix motif with score 1172.000, SD 3.18 at aa 262-283, sequence YTDTELAKHLGISRKSLWEKRR 936155000645 HMMPfam hit to PF00072, Response_reg, score 3.3e-09 936155000646 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 936155000647 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 936155000648 substrate binding site; other site 936155000649 dimer interface; other site 936155000650 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 936155000651 homotrimer interaction site [polypeptide binding]; other site 936155000652 zinc binding site [ion binding]; other site 936155000653 CDP-binding sites; other site 936155000654 HMMPfam hit to PF02542, YgbB, score 5.3e-76 936155000655 HMMPfam hit to PF01128, IspD, score 9.1e-14 936155000656 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 936155000657 ThiC family; Region: ThiC; pfam01964 936155000658 HMMPfam hit to PF01964, ThiC, score 1.8e-295 936155000659 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 936155000660 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 936155000661 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 936155000662 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 936155000663 homodimer interface [polypeptide binding]; other site 936155000664 NADP binding site [chemical binding]; other site 936155000665 substrate binding site [chemical binding]; other site 936155000666 HMMPfam hit to PF00763, THF_DHG_CYH, score 2.7e-63 936155000667 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1 936155000668 HMMPfam hit to PF02882, THF_DHG_CYH_C, score 1.9e-90 936155000669 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2 936155000670 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 936155000671 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936155000672 Catalytic site [active] 936155000673 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936155000674 1 probable transmembrane helix predicted for Hfelis02290 by TMHMM2.0 at aa 9-31 936155000675 HMMPfam hit to PF00717, Peptidase_S24, score 1.1e-15 936155000676 PS00761 Signal peptidases I signature 3 936155000677 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 936155000678 HMMPfam hit to PF02502, LacAB_rpiB, score 2.5e-67 936155000679 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000680 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 936155000681 1 probable transmembrane helix predicted for Hfelis02310 by TMHMM2.0 at aa 5-25 936155000682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155000683 active site 936155000684 HMMPfam hit to PF00156, Pribosyltran, score 2e-40 936155000685 1 probable transmembrane helix predicted for Hfelis02320 by TMHMM2.0 at aa 62-84 936155000686 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 936155000687 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936155000688 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936155000689 5 probable transmembrane helices predicted for Hfelis02330 by TMHMM2.0 at aa 20-42, 47-69, 87-109, 130-152 and 167-184 936155000690 multifunctional aminopeptidase A; Provisional; Region: PRK00913 936155000691 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 936155000692 interface (dimer of trimers) [polypeptide binding]; other site 936155000693 Substrate-binding/catalytic site; other site 936155000694 Zn-binding sites [ion binding]; other site 936155000695 HMMPfam hit to PF02789, Peptidase_M17_N, score 1.3e-05 936155000696 HMMPfam hit to PF00883, Peptidase_M17, score 6e-178 936155000697 PS00631 Cytosol aminopeptidase signature 936155000698 GTP-binding protein YchF; Reviewed; Region: PRK09601 936155000699 YchF GTPase; Region: YchF; cd01900 936155000700 G1 box; other site 936155000701 GTP/Mg2+ binding site [chemical binding]; other site 936155000702 Switch I region; other site 936155000703 G2 box; other site 936155000704 Switch II region; other site 936155000705 G3 box; other site 936155000706 G4 box; other site 936155000707 G5 box; other site 936155000708 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 936155000709 HMMPfam hit to PF01926, MMR_HSR1, score 4.6e-36 936155000710 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000711 PS00012 Phosphopantetheine attachment site 936155000712 HMMPfam hit to PF06071, YchF-GTPase_C, score 6.4e-59 936155000713 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 936155000714 Response regulator receiver domain; Region: Response_reg; pfam00072 936155000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155000716 active site 936155000717 phosphorylation site [posttranslational modification] 936155000718 intermolecular recognition site; other site 936155000719 dimerization interface [polypeptide binding]; other site 936155000720 HMMPfam hit to PF01584, CheW, score 8e-26 936155000721 HMMPfam hit to PF00072, Response_reg, score 7.4e-13 936155000722 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 936155000723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 936155000724 dimer interface [polypeptide binding]; other site 936155000725 active site 936155000726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936155000727 catalytic residues [active] 936155000728 substrate binding site [chemical binding]; other site 936155000729 HMMPfam hit to PF00278, Orn_DAP_Arg_deC, score 1.1e-23 936155000730 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000731 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 936155000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155000733 S-adenosylmethionine binding site [chemical binding]; other site 936155000734 PS00092 N-6 Adenine-specific DNA methylases signature 936155000735 HMMPfam hit to PF05175, MTS, score 5.7e-07 936155000736 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 936155000737 HMMPfam hit to PF02667, SCFA_trans, score 4.5e-222 936155000738 11 probable transmembrane helices predicted for Hfelis02390 by TMHMM2.0 at aa 20-40, 53-75, 95-117, 138-160, 187-209, 248-266, 270-287, 308-330, 343-365, 377-399 and 424-446 936155000739 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 936155000740 HMMPfam hit to PF02642, DUF191, score 4.1e-121 936155000741 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 936155000742 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936155000743 HMMPfam hit to PF00561, Abhydrolase_1, score 7.6e-11 936155000744 PS00120 Lipases, serine active site 936155000745 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 936155000746 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 936155000747 HMMPfam hit to PF01312, Bac_export_2, score 1.2e-96 936155000748 4 probable transmembrane helices predicted for Hfelis02420 by TMHMM2.0 at aa 29-51, 89-111, 143-165 and 186-208 936155000749 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 936155000750 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 936155000751 GTP binding site; other site 936155000752 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155000753 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 936155000754 HMMPfam hit to PF00534, Glycos_transf_1, score 1.3e-22 936155000755 1 probable transmembrane helix predicted for Hfelis02440 by TMHMM2.0 at aa 5-27 936155000756 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 936155000757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155000758 FeS/SAM binding site; other site 936155000759 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 936155000760 HMMPfam hit to PF04055, Radical_SAM, score 4.9e-38 936155000761 PS01305 moaA / nifB / pqqE family signature 936155000762 HMMPfam hit to PF06463, Mob_synth_C, score 3.6e-38 936155000763 hypothetical protein; Provisional; Region: PRK08444 936155000764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155000765 FeS/SAM binding site; other site 936155000766 HMMPfam hit to PF04055, Radical_SAM, score 3.5e-17 936155000767 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936155000768 HMMPfam hit to PF00218, IGPS, score 4e-05 936155000769 PS00148 Arginase family signature 2 936155000770 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 936155000771 Flagellin N-methylase; Region: FliB; pfam03692 936155000772 HMMPfam hit to PF03692, UPF0153, score 8.3e-13 936155000773 1 probable transmembrane helix predicted for Hfelis02500 by TMHMM2.0 at aa 22-44 936155000774 1 probable transmembrane helix predicted for Hfelis02510 by TMHMM2.0 at aa 20-39 936155000775 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 936155000776 putative acyl-acceptor binding pocket; other site 936155000777 HMMPfam hit to PF04028, DUF374, score 2.8e-31 936155000778 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936155000779 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 936155000780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155000781 FeS/SAM binding site; other site 936155000782 TRAM domain; Region: TRAM; cl01282 936155000783 HMMPfam hit to PF01938, TRAM, score 1.2e-05 936155000784 HMMPfam hit to PF04055, Radical_SAM, score 2e-30 936155000785 PS01278 Uncharacterized protein family UPF0004 signature 936155000786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000787 HMMPfam hit to PF00919, UPF0004, score 2.2e-49 936155000788 chlorohydrolase; Provisional; Region: PRK08418 936155000789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936155000790 active site 936155000791 HMMPfam hit to PF01979, Amidohydro_1, score 4.1e-22 936155000792 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000793 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936155000794 dihydroorotase; Provisional; Region: PRK08417 936155000795 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936155000796 active site 936155000797 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 936155000798 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 936155000799 6 probable transmembrane helices predicted for Hfelis02580 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 140-162, 172-194 and 215-237 936155000800 HMMPfam hit to PF02683, DsbD, score 1.8e-62 936155000801 helicase 45; Provisional; Region: PTZ00424 936155000802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936155000803 ATP binding site [chemical binding]; other site 936155000804 Mg++ binding site [ion binding]; other site 936155000805 motif III; other site 936155000806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936155000807 nucleotide binding region [chemical binding]; other site 936155000808 ATP-binding site [chemical binding]; other site 936155000809 HMMPfam hit to PF00270, DEAD, score 8.9e-72 936155000810 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000811 HMMPfam hit to PF00271, Helicase_C, score 3e-37 936155000812 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 936155000813 SPFH domain / Band 7 family; Region: Band_7; pfam01145 936155000814 1 probable transmembrane helix predicted for Hfelis02600 by TMHMM2.0 at aa 45-67 936155000815 HMMPfam hit to PF01145, Band_7, score 8.7e-44 936155000816 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 936155000817 2 probable transmembrane helices predicted for Hfelis02610 by TMHMM2.0 at aa 21-43 and 47-69 936155000818 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 936155000819 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000820 flavodoxin FldA; Validated; Region: PRK09267 936155000821 HMMPfam hit to PF00258, Flavodoxin_1, score 1.8e-37 936155000822 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 936155000823 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000824 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 936155000825 tellurium resistance terB-like protein; Region: terB_like; cl11965 936155000826 metal binding site [ion binding]; metal-binding site 936155000827 1 probable transmembrane helix predicted for Hfelis02700 by TMHMM2.0 at aa 31-53 936155000828 1 probable transmembrane helix predicted for Hfelis02710 by TMHMM2.0 at aa 30-52 936155000829 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000830 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 936155000831 NeuB family; Region: NeuB; pfam03102 936155000832 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 936155000833 NeuB binding interface [polypeptide binding]; other site 936155000834 putative substrate binding site [chemical binding]; other site 936155000835 HMMPfam hit to PF03102, NeuB, score 1.3e-77 936155000836 HMMPfam hit to PF08666, SAF, score 1.9e-10 936155000837 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 936155000838 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 936155000839 active site 936155000840 homodimer interface [polypeptide binding]; other site 936155000841 HMMPfam hit to PF02350, Epimerase_2, score 8.2e-64 936155000842 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 936155000843 ligand binding site; other site 936155000844 tetramer interface; other site 936155000845 HMMPfam hit to PF02348, CTP_transf_3, score 3.4e-21 936155000846 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 936155000847 HMMPfam hit to PF06002, CST-I, score 3.9e-26 936155000848 PS00225 Crystallins beta and gamma 'Greek key' motif signature 936155000849 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 936155000850 HMMPfam hit to PF06002, CST-I, score 1.2e-31 936155000851 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 936155000852 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 936155000853 G1 box; other site 936155000854 putative GEF interaction site [polypeptide binding]; other site 936155000855 GTP/Mg2+ binding site [chemical binding]; other site 936155000856 Switch I region; other site 936155000857 G2 box; other site 936155000858 G3 box; other site 936155000859 Switch II region; other site 936155000860 G4 box; other site 936155000861 G5 box; other site 936155000862 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 936155000863 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 936155000864 HMMPfam hit to PF00009, GTP_EFTU, score 1.7e-75 936155000865 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000866 PS00301 GTP-binding elongation factors signature 936155000867 HMMPfam hit to PF03144, GTP_EFTU_D2, score 3e-13 936155000868 HMMPfam hit to PF00679, EFG_C, score 1.2e-31 936155000869 PS00216 Sugar transport proteins signature 1 936155000870 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 936155000871 ATP cone domain; Region: ATP-cone; pfam03477 936155000872 Class I ribonucleotide reductase; Region: RNR_I; cd01679 936155000873 active site 936155000874 dimer interface [polypeptide binding]; other site 936155000875 catalytic residues [active] 936155000876 effector binding site; other site 936155000877 R2 peptide binding site; other site 936155000878 HMMPfam hit to PF03477, ATP-cone, score 2.6e-16 936155000879 HMMPfam hit to PF00317, Ribonuc_red_lgN, score 1.3e-31 936155000880 HMMPfam hit to PF02867, Ribonuc_red_lgC, score 7.2e-130 936155000881 PS00089 Ribonucleotide reductase large subunit signature 936155000882 2 probable transmembrane helices predicted for Hfelis02790 by TMHMM2.0 at aa 4-18 and 25-44 936155000883 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 936155000884 HMMPfam hit to PF02600, DsbB, score 9.4e-19 936155000885 5 probable transmembrane helices predicted for Hfelis02800 by TMHMM2.0 at aa 7-29, 44-63, 68-85, 114-136 and 157-179 936155000886 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 936155000887 active site 936155000888 HMMPfam hit to PF03061, 4HBT, score 1.6e-14 936155000889 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site 936155000890 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 936155000891 Na2 binding site [ion binding]; other site 936155000892 putative substrate binding site 1 [chemical binding]; other site 936155000893 Na binding site 1 [ion binding]; other site 936155000894 putative substrate binding site 2 [chemical binding]; other site 936155000895 HMMPfam hit to PF00209, SNF, score 3.5e-11 936155000896 12 probable transmembrane helices predicted for Hfelis02820 by TMHMM2.0 at aa 7-24, 34-56, 88-110, 138-157, 170-192, 212-234, 247-269, 274-292, 299-321, 336-358, 379-401 and 416-438 936155000897 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 936155000898 Na2 binding site [ion binding]; other site 936155000899 putative substrate binding site 1 [chemical binding]; other site 936155000900 Na binding site 1 [ion binding]; other site 936155000901 putative substrate binding site 2 [chemical binding]; other site 936155000902 HMMPfam hit to PF00209, SNF, score 8.1e-12 936155000903 11 probable transmembrane helices predicted for Hfelis02830 by TMHMM2.0 at aa 7-29, 33-55, 86-108, 136-158, 165-187, 212-234, 246-268, 297-319, 339-357, 377-399 and 419-441 936155000904 PS00610 Sodium:neurotransmitter symporter family signature 1 936155000905 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 936155000906 dimerization interface [polypeptide binding]; other site 936155000907 substrate binding site [chemical binding]; other site 936155000908 active site 936155000909 calcium binding site [ion binding]; other site 936155000910 HMMPfam hit to PF02253, PLA1, score 2.8e-144 936155000911 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 936155000912 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 936155000913 putative ligand binding site [chemical binding]; other site 936155000914 putative NAD binding site [chemical binding]; other site 936155000915 catalytic site [active] 936155000916 HMMPfam hit to PF02826, 2-Hacid_dh_C, score 2.8e-56 936155000917 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 936155000918 HMMPfam hit to PF00389, 2-Hacid_dh, score 6.2e-10 936155000919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936155000920 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 936155000921 putative active site [active] 936155000922 heme pocket [chemical binding]; other site 936155000923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936155000924 putative active site [active] 936155000925 heme pocket [chemical binding]; other site 936155000926 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155000927 dimer interface [polypeptide binding]; other site 936155000928 putative CheW interface [polypeptide binding]; other site 936155000929 HMMPfam hit to PF00015, MCPsignal, score 1.3e-38 936155000930 HMMPfam hit to PF08447, PAS_3, score 2.6e-14 936155000931 HMMPfam hit to PF08447, PAS_3, score 3.4e-12 936155000932 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 936155000933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936155000934 substrate binding pocket [chemical binding]; other site 936155000935 membrane-bound complex binding site; other site 936155000936 hinge residues; other site 936155000937 HMMPfam hit to PF00497, SBP_bac_3, score 8e-42 936155000938 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155000939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936155000940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936155000941 Walker A/P-loop; other site 936155000942 ATP binding site [chemical binding]; other site 936155000943 Q-loop/lid; other site 936155000944 ABC transporter signature motif; other site 936155000945 Walker B; other site 936155000946 D-loop; other site 936155000947 H-loop/switch region; other site 936155000948 HMMPfam hit to PF00005, ABC_tran, score 9.7e-64 936155000949 PS00211 ABC transporters family signature 936155000950 PS00017 ATP/GTP-binding site motif A (P-loop) 936155000951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155000952 dimer interface [polypeptide binding]; other site 936155000953 conserved gate region; other site 936155000954 putative PBP binding loops; other site 936155000955 ABC-ATPase subunit interface; other site 936155000956 5 probable transmembrane helices predicted for Hfelis02890 by TMHMM2.0 at aa 22-44, 65-87, 133-155, 162-181 and 191-213 936155000957 HMMPfam hit to PF00528, BPD_transp_1, score 7.1e-14 936155000958 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 936155000959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155000960 dimer interface [polypeptide binding]; other site 936155000961 conserved gate region; other site 936155000962 putative PBP binding loops; other site 936155000963 ABC-ATPase subunit interface; other site 936155000964 HMMPfam hit to PF00528, BPD_transp_1, score 2.5e-17 936155000965 3 probable transmembrane helices predicted for Hfelis02900 by TMHMM2.0 at aa 20-39, 75-97 and 181-203 936155000966 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 936155000967 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 936155000968 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 936155000969 substrate binding site [chemical binding]; other site 936155000970 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 936155000971 substrate binding site [chemical binding]; other site 936155000972 ligand binding site [chemical binding]; other site 936155000973 HMMPfam hit to PF00330, Aconitase, score 2.6e-16 936155000974 PS00450 Aconitase family signature 1 936155000975 HMMPfam hit to PF06434, Aconitase_2_N, score 2.7e-234 936155000976 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 936155000977 HMMPfam hit to PF02621, DUF178, score 5.9e-46 936155000978 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936155000979 8 probable transmembrane helices predicted for Hfelis02960 by TMHMM2.0 at aa 7-29, 44-62, 75-97, 101-118, 139-168, 178-197, 210-229 and 239-256 936155000980 HMMPfam hit to PF01925, DUF81, score 1.5e-31 936155000981 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 936155000982 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 936155000983 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 936155000984 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 936155000985 Autotransporter beta-domain; Region: Autotransporter; pfam03797 936155000986 HMMPfam hit to PF03077, VacA2, score 4.2e-24 936155000987 HMMPfam hit to PF03077, VacA2, score 1.4e-09 936155000988 HMMPfam hit to PF03077, VacA2, score 1.9e-24 936155000989 HMMPfam hit to PF03797, Autotransporter, score 2.5e-26 936155000990 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 936155000991 ATP-NAD kinase; Region: NAD_kinase; pfam01513 936155000992 HMMPfam hit to PF01513, NAD_kinase, score 1e-47 936155000993 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 936155000994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155000995 Walker A/P-loop; other site 936155000996 ATP binding site [chemical binding]; other site 936155000997 Q-loop/lid; other site 936155000998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155000999 ABC transporter signature motif; other site 936155001000 Walker B; other site 936155001001 D-loop; other site 936155001002 H-loop/switch region; other site 936155001003 HMMPfam hit to PF02463, SMC_N, score 2.5e-09 936155001004 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001005 PS00211 ABC transporters family signature 936155001006 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 936155001007 Domain of unknown function (DUF814); Region: DUF814; pfam05670 936155001008 HMMPfam hit to PF05833, FbpA, score 5.9e-08 936155001009 HMMPfam hit to PF05670, DUF814, score 3.7e-12 936155001010 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 936155001011 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 936155001012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155001013 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 936155001014 HMMPfam hit to PF02844, GARS_N, score 7.4e-34 936155001015 HMMPfam hit to PF01071, GARS_A, score 9.9e-40 936155001016 HMMPfam hit to PF02843, GARS_C, score 7.3e-18 936155001017 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001018 RDD family; Region: RDD; pfam06271 936155001019 HMMPfam hit to PF06271, RDD, score 0.0002 936155001020 2 probable transmembrane helices predicted for Hfelis03020 by TMHMM2.0 at aa 21-40 and 65-87 936155001021 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 936155001022 Organic solvent tolerance protein; Region: OstA_C; pfam04453 936155001023 HMMPfam hit to PF04453, OstA_C, score 9.3e-21 936155001024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155001025 active site 936155001026 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 936155001027 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 936155001028 oligomer interface [polypeptide binding]; other site 936155001029 RNA binding site [nucleotide binding]; other site 936155001030 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 936155001031 oligomer interface [polypeptide binding]; other site 936155001032 RNA binding site [nucleotide binding]; other site 936155001033 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 936155001034 putative nucleic acid binding region [nucleotide binding]; other site 936155001035 G-X-X-G motif; other site 936155001036 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 936155001037 RNA binding site [nucleotide binding]; other site 936155001038 HMMPfam hit to PF01138, RNase_PH, score 1.5e-15 936155001039 HMMPfam hit to PF03725, RNase_PH_C, score 1.7e-10 936155001040 HMMPfam hit to PF03726, PNPase, score 0.00061 936155001041 HMMPfam hit to PF01138, RNase_PH, score 6.4e-42 936155001042 HMMPfam hit to PF03725, RNase_PH_C, score 1.6e-16 936155001043 HMMPfam hit to PF00013, KH_1, score 2.9e-14 936155001044 HMMPfam hit to PF00575, S1, score 7.9e-06 936155001045 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 936155001046 3 probable transmembrane helices predicted for Hfelis03060 by TMHMM2.0 at aa 4-26, 33-55 and 75-97 936155001047 HMMPfam hit to PF00137, ATP-synt_C, score 3.2e-12 936155001048 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001049 PS00605 ATP synthase c subunit signature 936155001050 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 936155001051 HMMPfam hit to PF06518, DUF1104, score 4.5e-30 936155001052 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 936155001053 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 936155001054 TPP-binding site; other site 936155001055 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936155001056 PYR/PP interface [polypeptide binding]; other site 936155001057 dimer interface [polypeptide binding]; other site 936155001058 TPP binding site [chemical binding]; other site 936155001059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936155001060 HMMPfam hit to PF02780, Transketolase_C, score 2.2e-18 936155001061 HMMPfam hit to PF02779, Transket_pyr, score 2e-54 936155001062 HMMPfam hit to PF00456, Transketolase_N, score 4.2e-05 936155001063 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001064 PS00801 Transketolase signature 1 936155001065 flagellar assembly protein H; Validated; Region: fliH; PRK06669 936155001066 Flagellar assembly protein FliH; Region: FliH; pfam02108 936155001067 HMMPfam hit to PF02108, FliH, score 7.7e-26 936155001068 flagellar motor switch protein FliG; Region: fliG; TIGR00207 936155001069 FliG C-terminal domain; Region: FliG_C; pfam01706 936155001070 HMMPfam hit to PF01706, FliG_C, score 4e-49 936155001071 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 936155001072 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 936155001073 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 936155001074 2 probable transmembrane helices predicted for Hfelis03110 by TMHMM2.0 at aa 23-42 and 445-467 936155001075 HMMPfam hit to PF08345, YscJ_FliF_C, score 1.1e-68 936155001076 HMMPfam hit to PF01514, YscJ_FliF, score 2e-70 936155001077 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 936155001078 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936155001079 active site 936155001080 HMMPfam hit to PF01569, PAP2, score 5.8e-28 936155001081 5 probable transmembrane helices predicted for Hfelis03120 by TMHMM2.0 at aa 45-67, 74-96, 116-138, 145-163 and 173-195 936155001082 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 936155001083 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155001084 molybdopterin cofactor binding site; other site 936155001085 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155001086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155001087 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 936155001088 molybdopterin cofactor binding site; other site 936155001089 HMMPfam hit to PF04879, Molybdop_Fe4S4, score 1.2e-23 936155001090 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 936155001091 HMMPfam hit to PF00384, Molybdopterin, score 1.6e-94 936155001092 HMMPfam hit to PF01568, Molydop_binding, score 1.4e-28 936155001093 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 936155001094 RNA/DNA hybrid binding site [nucleotide binding]; other site 936155001095 active site 936155001096 HMMPfam hit to PF01351, RNase_HII, score 3.2e-43 936155001097 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001098 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155001099 HMMPfam hit to PF08238, Sel1, score 0.00016 936155001100 HMMPfam hit to PF08238, Sel1, score 2.5 936155001101 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 936155001102 HMMPfam hit to PF01245, Ribosomal_L19, score 1.2e-66 936155001103 PS01015 Ribosomal protein L19 signature 936155001104 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 936155001105 HMMPfam hit to PF01746, tRNA_m1G_MT, score 9.9e-48 936155001106 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 936155001107 RimM N-terminal domain; Region: RimM; pfam01782 936155001108 HMMPfam hit to PF01782, RimM, score 3.5e-08 936155001109 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 936155001110 KH domain; Region: KH_4; pfam13083 936155001111 G-X-X-G motif; other site 936155001112 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 936155001113 HMMPfam hit to PF00886, Ribosomal_S16, score 2e-31 936155001114 PS00732 Ribosomal protein S16 signature 936155001115 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 936155001116 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 936155001117 dimer interface [polypeptide binding]; other site 936155001118 active site 936155001119 CoA binding pocket [chemical binding]; other site 936155001120 HMMPfam hit to PF08541, ACP_syn_III_C, score 2e-49 936155001121 HMMPfam hit to PF08545, ACP_syn_III, score 1.7e-37 936155001122 putative phosphate acyltransferase; Provisional; Region: PRK05331 936155001123 HMMPfam hit to PF02504, FA_synthesis, score 2.4e-148 936155001124 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 936155001125 HMMPfam hit to PF01783, Ribosomal_L32p, score 2.3e-05 936155001126 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 936155001127 active site 936155001128 multimer interface [polypeptide binding]; other site 936155001129 HMMPfam hit to PF00334, NDK, score 3.4e-72 936155001130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 936155001131 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001132 HMMPfam hit to PF07282, Transposase_35, score 4.5e-25 936155001133 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 936155001134 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 936155001135 DNA binding residues [nucleotide binding] 936155001136 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 936155001137 catalytic residues [active] 936155001138 catalytic nucleophile [active] 936155001139 HMMPfam hit to PF00239, Resolvase, score 6.2e-17 936155001140 PS00397 Site-specific recombinases active site 936155001141 HMMPfam hit to PF00376, MerR, score 1.1e-12 936155001142 PS00552 Bacterial regulatory proteins, merR family signature 936155001143 Predicted helix-turn-helix motif with score 1993.000, SD 5.97 at aa 5-26, sequence LSIGQASKVLGVSIQTLRNWEK 936155001144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 936155001145 DNA polymerase III subunit beta; Validated; Region: PRK05643 936155001146 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 936155001147 putative DNA binding surface [nucleotide binding]; other site 936155001148 dimer interface [polypeptide binding]; other site 936155001149 beta-clamp/clamp loader binding surface; other site 936155001150 beta-clamp/translesion DNA polymerase binding surface; other site 936155001151 HMMPfam hit to PF02767, DNA_pol3_beta_2, score 1.8e-06 936155001152 HMMPfam hit to PF00712, DNA_pol3_beta, score 3.6e-07 936155001153 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936155001154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155001155 Walker A motif; other site 936155001156 ATP binding site [chemical binding]; other site 936155001157 Walker B motif; other site 936155001158 arginine finger; other site 936155001159 HMMPfam hit to PF00004, AAA, score 4.9e-41 936155001160 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001161 PS00589 PTS HPR component serine phosphorylation site signature 936155001162 GTP-binding protein Der; Reviewed; Region: PRK00093 936155001163 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 936155001164 G1 box; other site 936155001165 GTP/Mg2+ binding site [chemical binding]; other site 936155001166 Switch I region; other site 936155001167 G2 box; other site 936155001168 Switch II region; other site 936155001169 G3 box; other site 936155001170 G4 box; other site 936155001171 G5 box; other site 936155001172 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 936155001173 G1 box; other site 936155001174 GTP/Mg2+ binding site [chemical binding]; other site 936155001175 Switch I region; other site 936155001176 G2 box; other site 936155001177 G3 box; other site 936155001178 Switch II region; other site 936155001179 G4 box; other site 936155001180 G5 box; other site 936155001181 HMMPfam hit to PF01926, MMR_HSR1, score 1.1e-38 936155001182 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001183 HMMPfam hit to PF01926, MMR_HSR1, score 1.8e-36 936155001184 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001185 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001186 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 936155001187 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 936155001188 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 936155001189 HMMPfam hit to PF01039, Carboxyl_trans, score 1.1e-10 936155001190 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 936155001191 HMMPfam hit to PF02590, SPOUT_MTase, score 1.9e-42 936155001192 1 probable transmembrane helix predicted for Hfelis03400 by TMHMM2.0 at aa 55-77 936155001193 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936155001194 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 936155001195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936155001196 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936155001197 HMMPfam hit to PF07992, Pyr_redox_2, score 1e-42 936155001198 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001199 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site 936155001200 HMMPfam hit to PF02852, Pyr_redox_dim, score 1.6e-05 936155001201 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 936155001202 active site 936155001203 homodimer interface [polypeptide binding]; other site 936155001204 homotetramer interface [polypeptide binding]; other site 936155001205 HMMPfam hit to PF00710, Asparaginase, score 1.1e-152 936155001206 PS00144 Asparaginase / glutaminase active site signature 1 936155001207 PS00917 Asparaginase / glutaminase active site signature 2 936155001208 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 936155001209 HMMPfam hit to PF03150, CCP_MauG, score 2.9e-74 936155001210 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 936155001211 HMMPfam hit to PF00830, Ribosomal_L28, score 5.7e-15 936155001212 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 936155001213 TrkA-N domain; Region: TrkA_N; pfam02254 936155001214 TrkA-C domain; Region: TrkA_C; pfam02080 936155001215 2 probable transmembrane helices predicted for Hfelis03460 by TMHMM2.0 at aa 36-58 and 87-109 936155001216 HMMPfam hit to PF02254, TrkA_N, score 2.3e-20 936155001217 HMMPfam hit to PF02080, TrkA_C, score 1.2e-09 936155001218 PS00881 Protein splicing signature 936155001219 1 probable transmembrane helix predicted for Hfelis03490 by TMHMM2.0 at aa 21-40 936155001220 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 936155001221 HMMPfam hit to PF01227, GTP_cyclohydroI, score 3.6e-32 936155001222 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 936155001223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936155001224 active site 936155001225 HIGH motif; other site 936155001226 nucleotide binding site [chemical binding]; other site 936155001227 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 936155001228 active site 936155001229 KMSKS motif; other site 936155001230 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 936155001231 tRNA binding surface [nucleotide binding]; other site 936155001232 anticodon binding site; other site 936155001233 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 936155001234 HMMPfam hit to PF06827, zf-FPG_IleRS, score 0.00011 936155001235 HMMPfam hit to PF08264, Anticodon_1, score 3e-19 936155001236 HMMPfam hit to PF00133, tRNA-synt_1, score 7.6e-232 936155001237 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001238 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155001239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155001240 RNA binding surface [nucleotide binding]; other site 936155001241 HMMPfam hit to PF01479, S4, score 7.6e-10 936155001242 elongation factor G; Reviewed; Region: PRK00007 936155001243 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 936155001244 G1 box; other site 936155001245 putative GEF interaction site [polypeptide binding]; other site 936155001246 GTP/Mg2+ binding site [chemical binding]; other site 936155001247 Switch I region; other site 936155001248 G2 box; other site 936155001249 G3 box; other site 936155001250 Switch II region; other site 936155001251 G4 box; other site 936155001252 G5 box; other site 936155001253 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 936155001254 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 936155001255 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 936155001256 HMMPfam hit to PF00679, EFG_C, score 6.8e-46 936155001257 HMMPfam hit to PF03764, EFG_IV, score 2.8e-72 936155001258 HMMPfam hit to PF03144, GTP_EFTU_D2, score 1.8e-20 936155001259 HMMPfam hit to PF00009, GTP_EFTU, score 2.4e-138 936155001260 PS00301 GTP-binding elongation factors signature 936155001261 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001262 30S ribosomal protein S7; Validated; Region: PRK05302 936155001263 HMMPfam hit to PF00177, Ribosomal_S7, score 6.6e-79 936155001264 PS00052 Ribosomal protein S7 signature 936155001265 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 936155001266 S17 interaction site [polypeptide binding]; other site 936155001267 S8 interaction site; other site 936155001268 16S rRNA interaction site [nucleotide binding]; other site 936155001269 streptomycin interaction site [chemical binding]; other site 936155001270 23S rRNA interaction site [nucleotide binding]; other site 936155001271 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 936155001272 HMMPfam hit to PF00164, Ribosomal_S12, score 2.3e-72 936155001273 PS00055 Ribosomal protein S12 signature 936155001274 Biofilm formation and stress response factor; Region: BsmA; cl01794 936155001275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936155001276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 936155001277 dimer interface [polypeptide binding]; other site 936155001278 phosphorylation site [posttranslational modification] 936155001279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155001280 ATP binding site [chemical binding]; other site 936155001281 Mg2+ binding site [ion binding]; other site 936155001282 G-X-G motif; other site 936155001283 HMMPfam hit to PF02518, HATPase_c, score 1.4e-14 936155001284 2 probable transmembrane helices predicted for Hfelis03560 by TMHMM2.0 at aa 15-35 and 152-174 936155001285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936155001286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155001287 active site 936155001288 phosphorylation site [posttranslational modification] 936155001289 intermolecular recognition site; other site 936155001290 dimerization interface [polypeptide binding]; other site 936155001291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936155001292 DNA binding site [nucleotide binding] 936155001293 HMMPfam hit to PF00486, Trans_reg_C, score 1.9e-21 936155001294 HMMPfam hit to PF00072, Response_reg, score 5.2e-24 936155001295 6 probable transmembrane helices predicted for Hfelis03580 by TMHMM2.0 at aa 11-33, 48-69, 76-98, 123-145, 152-174 and 184-206 936155001296 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001297 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936155001298 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936155001299 active site 936155001300 metal binding site [ion binding]; metal-binding site 936155001301 HMMPfam hit to PF01520, Amidase_3, score 1.6e-74 936155001302 Nitronate monooxygenase; Region: NMO; pfam03060 936155001303 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 936155001304 FMN binding site [chemical binding]; other site 936155001305 substrate binding site [chemical binding]; other site 936155001306 putative catalytic residue [active] 936155001307 HMMPfam hit to PF03060, NPD, score 1.4e-129 936155001308 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 936155001309 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 936155001310 active site 936155001311 HIGH motif; other site 936155001312 dimer interface [polypeptide binding]; other site 936155001313 KMSKS motif; other site 936155001314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155001315 RNA binding surface [nucleotide binding]; other site 936155001316 HMMPfam hit to PF01479, S4, score 0.013 936155001317 HMMPfam hit to PF00579, tRNA-synt_1b, score 5.2e-100 936155001318 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155001319 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 936155001320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936155001321 Zn2+ binding site [ion binding]; other site 936155001322 Mg2+ binding site [ion binding]; other site 936155001323 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936155001324 synthetase active site [active] 936155001325 NTP binding site [chemical binding]; other site 936155001326 metal binding site [ion binding]; metal-binding site 936155001327 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 936155001328 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 936155001329 HMMPfam hit to PF02824, TGS, score 4.7e-19 936155001330 HMMPfam hit to PF04607, RelA_SpoT, score 7.1e-44 936155001331 HMMPfam hit to PF01966, HD, score 1.3e-07 936155001332 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 936155001333 HMMPfam hit to PF01192, RNA_pol_Rpb6, score 2.2e-09 936155001334 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 936155001335 putative nucleotide binding site [chemical binding]; other site 936155001336 uridine monophosphate binding site [chemical binding]; other site 936155001337 homohexameric interface [polypeptide binding]; other site 936155001338 HMMPfam hit to PF00696, AA_kinase, score 3.6e-64 936155001339 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 936155001340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936155001341 inhibitor-cofactor binding pocket; inhibition site 936155001342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155001343 catalytic residue [active] 936155001344 PS00225 Crystallins beta and gamma 'Greek key' motif signature 936155001345 HMMPfam hit to PF00202, Aminotran_3, score 3.8e-101 936155001346 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001347 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site 936155001348 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 936155001349 SurA N-terminal domain; Region: SurA_N_3; cl07813 936155001350 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 936155001351 1 probable transmembrane helix predicted for Hfelis03660 by TMHMM2.0 at aa 7-29 936155001352 cell division protein FtsA; Region: ftsA; TIGR01174 936155001353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936155001354 nucleotide binding site [chemical binding]; other site 936155001355 Cell division protein FtsA; Region: FtsA; pfam14450 936155001356 HMMPfam hit to PF02491, FtsA, score 1.7e-53 936155001357 HMMPfam hit to PF02491, FtsA, score 3.7e-43 936155001358 cell division protein FtsZ; Validated; Region: PRK09330 936155001359 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 936155001360 nucleotide binding site [chemical binding]; other site 936155001361 SulA interaction site; other site 936155001362 HMMPfam hit to PF00091, Tubulin, score 3.2e-77 936155001363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001364 PS01135 FtsZ protein signature 2 936155001365 HMMPfam hit to PF03953, Tubulin_C, score 1.1e-16 936155001366 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 936155001367 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 936155001368 HMMPfam hit to PF01702, TGT, score 6e-121 936155001369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 936155001370 TrkA-C domain; Region: TrkA_C; pfam02080 936155001371 HMMPfam hit to PF02080, TrkA_C, score 1.4e-14 936155001372 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 936155001373 active site 936155001374 dimer interface [polypeptide binding]; other site 936155001375 metal binding site [ion binding]; metal-binding site 936155001376 HMMPfam hit to PF01761, DHQ_synthase, score 2.2e-139 936155001377 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936155001378 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936155001379 2 probable transmembrane helices predicted for Hfelis03720 by TMHMM2.0 at aa 224-241 and 262-284 936155001380 HMMPfam hit to PF00924, MS_channel, score 9.9e-18 936155001381 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936155001382 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936155001383 3 probable transmembrane helices predicted for Hfelis03730 by TMHMM2.0 at aa 231-253, 273-295 and 310-329 936155001384 HMMPfam hit to PF00924, MS_channel, score 9e-30 936155001385 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 936155001386 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936155001387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155001388 FeS/SAM binding site; other site 936155001389 HMMPfam hit to PF00919, UPF0004, score 1.2e-25 936155001390 HMMPfam hit to PF04055, Radical_SAM, score 5.9e-20 936155001391 PS01278 Uncharacterized protein family UPF0004 signature 936155001392 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 936155001393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155001394 Walker B motif; other site 936155001395 arginine finger; other site 936155001396 Peptidase family M41; Region: Peptidase_M41; pfam01434 936155001397 2 probable transmembrane helices predicted for Hfelis03750 by TMHMM2.0 at aa 15-35 and 106-128 936155001398 HMMPfam hit to PF00004, AAA, score 5.5e-87 936155001399 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001400 PS00674 AAA-protein family signature 936155001401 HMMPfam hit to PF01434, Peptidase_M41, score 5.8e-06 936155001402 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 936155001403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936155001404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936155001405 HMMPfam hit to PF01075, Glyco_transf_9, score 0.00038 936155001406 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 936155001407 HMMPfam hit to PF02525, Flavodoxin_2, score 1.1e-61 936155001408 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 936155001409 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 936155001410 Permutation of conserved domain; other site 936155001411 active site 936155001412 HMMPfam hit to PF01142, TruD, score 3.5e-91 936155001413 heat shock protein HtpX; Provisional; Region: PRK02870 936155001414 4 probable transmembrane helices predicted for Hfelis03810 by TMHMM2.0 at aa 13-35, 50-72, 179-201 and 211-233 936155001415 HMMPfam hit to PF01435, Peptidase_M48, score 2.2e-41 936155001416 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature 936155001417 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 936155001418 GTP cyclohydrolase I; Provisional; Region: PLN03044 936155001419 active site 936155001420 HMMPfam hit to PF01227, GTP_cyclohydroI, score 1.5e-46 936155001421 PS00860 GTP cyclohydrolase I signature 2 936155001422 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 936155001423 HMMPfam hit to PF01098, FTSW_RODA_SPOVE, score 1.1e-100 936155001424 10 probable transmembrane helices predicted for Hfelis03830 by TMHMM2.0 at aa 7-29, 39-58, 65-87, 102-124, 145-163, 167-186, 193-215, 293-315, 327-349 and 359-381 936155001425 PS00012 Phosphopantetheine attachment site 936155001426 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature 936155001427 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 936155001428 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 936155001429 HMMPfam hit to PF00460, Flg_bb_rod, score 0.00013 936155001430 PS00588 Flagella basal body rod proteins signature 936155001431 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 936155001432 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936155001433 HMMPfam hit to PF00460, Flg_bb_rod, score 1.7e-05 936155001434 PS00588 Flagella basal body rod proteins signature 936155001435 HMMPfam hit to PF06429, DUF1078, score 4.2e-07 936155001436 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 936155001437 HMMPfam hit to PF02049, FliE, score 2.4e-29 936155001438 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 936155001439 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936155001440 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936155001441 1 probable transmembrane helix predicted for Hfelis03870 by TMHMM2.0 at aa 27-49 936155001442 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001443 HMMPfam hit to PF03717, PBP_dimer, score 2.7e-12 936155001444 HMMPfam hit to PF00905, Transpeptidase, score 5.9e-77 936155001445 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001446 Domain of unknown function DUF59; Region: DUF59; pfam01883 936155001447 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 936155001448 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 936155001449 HMMPfam hit to PF01883, DUF59, score 0.0012 936155001450 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001451 PS01215 Mrp family signature 936155001452 HMMPfam hit to PF10609, ParA, score 3.8e-50 936155001453 Predicted membrane protein [Function unknown]; Region: COG1289 936155001454 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936155001455 8 probable transmembrane helices predicted for Hfelis03890 by TMHMM2.0 at aa 27-49, 69-86, 91-113, 147-166, 361-383, 403-425, 430-452 and 467-489 936155001456 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001457 Cache domain; Region: Cache_1; pfam02743 936155001458 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155001459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936155001460 dimerization interface [polypeptide binding]; other site 936155001461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155001462 dimer interface [polypeptide binding]; other site 936155001463 putative CheW interface [polypeptide binding]; other site 936155001464 HMMPfam hit to PF00015, MCPsignal, score 4e-34 936155001465 HMMPfam hit to PF00672, HAMP, score 2.2e-11 936155001466 2 probable transmembrane helices predicted for Hfelis03900 by TMHMM2.0 at aa 5-27 and 278-300 936155001467 HMMPfam hit to PF02743, Cache_1, score 7e-12 936155001468 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 936155001469 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936155001470 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936155001471 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 936155001472 HMMPfam hit to PF00005, ABC_tran, score 5.4e-24 936155001473 PS00211 ABC transporters family signature 936155001474 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001475 PS00211 ABC transporters family signature 936155001476 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001477 1 probable transmembrane helix predicted for Hfelis03920 by TMHMM2.0 at aa 15-37 936155001478 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 936155001479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155001480 Walker A/P-loop; other site 936155001481 ATP binding site [chemical binding]; other site 936155001482 Q-loop/lid; other site 936155001483 ABC transporter signature motif; other site 936155001484 Walker B; other site 936155001485 D-loop; other site 936155001486 H-loop/switch region; other site 936155001487 HMMPfam hit to PF00005, ABC_tran, score 7.8e-18 936155001488 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001489 6 probable transmembrane helices predicted for Hfelis03940 by TMHMM2.0 at aa 20-39, 54-76, 83-105, 109-131, 140-162 and 193-215 936155001490 HMMPfam hit to PF01061, ABC2_membrane, score 3.3e-06 936155001491 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155001492 HMMPfam hit to PF01856, HP_OMP, score 3.3e-05 936155001493 3 probable transmembrane helices predicted for Hfelis03950 by TMHMM2.0 at aa 5-24, 68-87 and 128-150 936155001494 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155001495 HMMPfam hit to PF01856, HP_OMP, score 0.001 936155001496 Predicted helix-turn-helix motif with score 1069.000, SD 2.83 at aa 769-790, sequence VPLTDASRQLVLTQSASTNVIT 936155001497 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155001498 HMMPfam hit to PF01856, HP_OMP, score 0.00054 936155001499 1 probable transmembrane helix predicted for Hfelis03970 by TMHMM2.0 at aa 699-721 936155001500 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936155001501 Peptidase family U32; Region: Peptidase_U32; pfam01136 936155001502 HMMPfam hit to PF01136, Peptidase_U32, score 3.8e-95 936155001503 PS01276 Peptidase family U32 signature 936155001504 peptide chain release factor 2; Validated; Region: prfB; PRK00578 936155001505 PCRF domain; Region: PCRF; pfam03462 936155001506 RF-1 domain; Region: RF-1; pfam00472 936155001507 HMMPfam hit to PF00472, RF-1, score 1.2e-69 936155001508 PS00745 Prokaryotic-type class I peptide chain release factors signature 936155001509 HMMPfam hit to PF03462, PCRF, score 6.4e-42 936155001510 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 936155001511 HMMPfam hit to PF01165, Ribosomal_S21, score 4.3e-29 936155001512 PS01181 Ribosomal protein S21 signature 936155001513 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 936155001514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936155001515 NAD(P) binding site [chemical binding]; other site 936155001516 active site 936155001517 HMMPfam hit to PF00106, adh_short, score 1.4e-27 936155001518 PS00061 Short-chain dehydrogenases/reductases family signature 936155001519 acyl carrier protein; Provisional; Region: acpP; PRK00982 936155001520 HMMPfam hit to PF00550, PP-binding, score 6.2e-19 936155001521 PS00012 Phosphopantetheine attachment site 936155001522 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 936155001523 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 936155001524 dimer interface [polypeptide binding]; other site 936155001525 active site 936155001526 HMMPfam hit to PF00109, ketoacyl-synt, score 1.4e-53 936155001527 HMMPfam hit to PF02801, Ketoacyl-synt_C, score 4.8e-46 936155001528 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 936155001529 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 936155001530 HMMPfam hit to PF03255, ACCA, score 2.2e-72 936155001531 HMMPfam hit to PF01039, Carboxyl_trans, score 5.1e-05 936155001532 flagellin A; Reviewed; Region: PRK12584 936155001533 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936155001534 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 936155001535 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 936155001536 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936155001537 HMMPfam hit to PF00669, Flagellin_N, score 4e-63 936155001538 HMMPfam hit to PF07196, Flagellin_IN, score 4.6e-10 936155001539 HMMPfam hit to PF07196, Flagellin_IN, score 8e-11 936155001540 HMMPfam hit to PF00700, Flagellin_C, score 9.3e-36 936155001541 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 936155001542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155001543 FeS/SAM binding site; other site 936155001544 HemN C-terminal domain; Region: HemN_C; pfam06969 936155001545 HMMPfam hit to PF06969, HemN_C, score 5.7e-19 936155001546 HMMPfam hit to PF04055, Radical_SAM, score 4.9e-19 936155001547 Cytochrome c; Region: Cytochrom_C; cl11414 936155001548 HMMPfam hit to PF00034, Cytochrom_C, score 0.0067 936155001549 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 936155001550 putative active site [active] 936155001551 Ap4A binding site [chemical binding]; other site 936155001552 nudix motif; other site 936155001553 putative metal binding site [ion binding]; other site 936155001554 HMMPfam hit to PF00293, NUDIX, score 2.4e-20 936155001555 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001556 PS00893 mutT domain signature 936155001557 aspartate kinase; Reviewed; Region: PRK06635 936155001558 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 936155001559 putative nucleotide binding site [chemical binding]; other site 936155001560 putative catalytic residues [active] 936155001561 putative Mg ion binding site [ion binding]; other site 936155001562 putative aspartate binding site [chemical binding]; other site 936155001563 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 936155001564 putative allosteric regulatory site; other site 936155001565 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 936155001566 putative allosteric regulatory residue; other site 936155001567 HMMPfam hit to PF00696, AA_kinase, score 2.8e-68 936155001568 PS00324 Aspartokinase signature 936155001569 HMMPfam hit to PF01842, ACT, score 1.9e-07 936155001570 HMMPfam hit to PF01842, ACT, score 3.2e-10 936155001571 DNA replication regulator; Region: HobA; pfam12163 936155001572 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001573 DNA polymerase III subunit delta'; Validated; Region: PRK08485 936155001574 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 936155001575 dihydropteroate synthase; Region: DHPS; TIGR01496 936155001576 substrate binding pocket [chemical binding]; other site 936155001577 dimer interface [polypeptide binding]; other site 936155001578 inhibitor binding site; inhibition site 936155001579 HMMPfam hit to PF00809, Pterin_bind, score 9.3e-61 936155001580 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936155001581 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 936155001582 HMMPfam hit to PF01490, Aa_trans, score 0.035 936155001583 11 probable transmembrane helices predicted for Hfelis04140 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 128-145, 152-174, 189-211, 232-254, 282-304, 335-357, 361-380 and 393-412 936155001584 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001585 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 936155001586 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936155001587 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 936155001588 HMMPfam hit to PF03315, SDH_beta, score 5.4e-45 936155001589 HMMPfam hit to PF03313, SDH_alpha, score 2.5e-141 936155001590 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 936155001591 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 936155001592 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 936155001593 HMMPfam hit to PF07715, Plug, score 7e-16 936155001594 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155001595 HMMPfam hit to PF00593, TonB_dep_Rec, score 3.2e-15 936155001596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936155001597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936155001598 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936155001599 HMMPfam hit to PF01408, GFO_IDH_MocA, score 5.5e-24 936155001600 HMMPfam hit to PF02894, GFO_IDH_MocA_C, score 5.7e-06 936155001601 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936155001602 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 936155001603 HMMPfam hit to PF01027, UPF0005, score 7.3e-46 936155001604 7 probable transmembrane helices predicted for Hfelis04180 by TMHMM2.0 at aa 35-57, 62-79, 86-108, 113-135, 148-165, 169-188 and 205-227 936155001605 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 936155001606 2 probable transmembrane helices predicted for Hfelis04200 by TMHMM2.0 at aa 20-42 and 63-85 936155001607 chaperone protein DnaJ; Provisional; Region: PRK14288 936155001608 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936155001609 HSP70 interaction site [polypeptide binding]; other site 936155001610 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 936155001611 substrate binding site [polypeptide binding]; other site 936155001612 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 936155001613 Zn binding sites [ion binding]; other site 936155001614 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 936155001615 dimer interface [polypeptide binding]; other site 936155001616 HMMPfam hit to PF01556, DnaJ_C, score 8.8e-38 936155001617 HMMPfam hit to PF00684, DnaJ_CXXCXGXG, score 1.2e-17 936155001618 PS00637 CXXCXGXG dnaJ domain signature 936155001619 HMMPfam hit to PF00226, DnaJ, score 1.1e-39 936155001620 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 936155001621 Flavoprotein; Region: Flavoprotein; pfam02441 936155001622 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 936155001623 HMMPfam hit to PF04127, DFP, score 1.4e-09 936155001624 HMMPfam hit to PF02441, Flavoprotein, score 8.4e-46 936155001625 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 936155001626 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 936155001627 NAD(P) binding site [chemical binding]; other site 936155001628 homodimer interface [polypeptide binding]; other site 936155001629 substrate binding site [chemical binding]; other site 936155001630 active site 936155001631 HMMPfam hit to PF02719, Polysacc_synt_2, score 1.6e-140 936155001632 LysE type translocator; Region: LysE; cl00565 936155001633 4 probable transmembrane helices predicted for Hfelis04260 by TMHMM2.0 at aa 36-58, 65-87, 137-159 and 178-195 936155001634 HMMPfam hit to PF01810, LysE, score 4.4e-39 936155001635 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 936155001636 active site 1 [active] 936155001637 dimer interface [polypeptide binding]; other site 936155001638 hexamer interface [polypeptide binding]; other site 936155001639 active site 2 [active] 936155001640 HMMPfam hit to PF01361, Tautomerase, score 3.8e-21 936155001641 ribosome maturation protein RimP; Reviewed; Region: PRK00092 936155001642 Sm and related proteins; Region: Sm_like; cl00259 936155001643 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 936155001644 putative oligomer interface [polypeptide binding]; other site 936155001645 putative RNA binding site [nucleotide binding]; other site 936155001646 HMMPfam hit to PF02576, DUF150, score 4.6e-43 936155001647 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 936155001648 HMMPfam hit to PF02033, RBFA, score 1.6e-05 936155001649 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936155001650 translation initiation factor IF-2; Region: IF-2; TIGR00487 936155001651 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936155001652 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 936155001653 G1 box; other site 936155001654 putative GEF interaction site [polypeptide binding]; other site 936155001655 GTP/Mg2+ binding site [chemical binding]; other site 936155001656 Switch I region; other site 936155001657 G2 box; other site 936155001658 G3 box; other site 936155001659 Switch II region; other site 936155001660 G4 box; other site 936155001661 G5 box; other site 936155001662 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 936155001663 Translation-initiation factor 2; Region: IF-2; pfam11987 936155001664 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 936155001665 HMMPfam hit to PF03144, GTP_EFTU_D2, score 4.4e-09 936155001666 PS01176 Initiation factor 2 signature 936155001667 HMMPfam hit to PF03144, GTP_EFTU_D2, score 6.1e-12 936155001668 HMMPfam hit to PF00009, GTP_EFTU, score 3.8e-60 936155001669 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001670 HMMPfam hit to PF04760, IF2_N, score 1.3e-17 936155001671 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 936155001672 putative RNA binding cleft [nucleotide binding]; other site 936155001673 HMMPfam hit to PF04296, DUF448, score 1.7e-05 936155001674 homoserine kinase; Provisional; Region: PRK01212 936155001675 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936155001676 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 936155001677 HMMPfam hit to PF08544, GHMP_kinases_C, score 9.8e-05 936155001678 HMMPfam hit to PF00288, GHMP_kinases_N, score 2.9e-14 936155001679 PS00627 GHMP kinases putative ATP-binding domain 936155001680 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 936155001681 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 936155001682 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 936155001683 HMMPfam hit to PF03331, LpxC, score 2.3e-142 936155001684 septum formation inhibitor; Reviewed; Region: minC; PRK00556 936155001685 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 936155001686 HMMPfam hit to PF03775, MinC_C, score 9.3e-08 936155001687 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936155001688 Peptidase family M23; Region: Peptidase_M23; pfam01551 936155001689 HMMPfam hit to PF01551, Peptidase_M23, score 7.3e-18 936155001690 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155001691 HMMPfam hit to PF01856, HP_OMP, score 1.8e-07 936155001692 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155001693 HMMPfam hit to PF01856, HP_OMP, score 1.4e-25 936155001694 1 probable transmembrane helix predicted for Hfelis04380 by TMHMM2.0 at aa 10-27 936155001695 Uncharacterized protein family (UPF0254); Region: UPF0254; cl01641 936155001696 HMMPfam hit to PF01856, HP_OMP, score 0.0024 936155001697 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 936155001698 active site 936155001699 oligomerization interface [polypeptide binding]; other site 936155001700 metal binding site [ion binding]; metal-binding site 936155001701 HMMPfam hit to PF02548, Pantoate_transf, score 2.4e-132 936155001702 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001703 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001704 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 936155001705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155001706 Walker A motif; other site 936155001707 ATP binding site [chemical binding]; other site 936155001708 Walker B motif; other site 936155001709 arginine finger; other site 936155001710 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 936155001711 HMMPfam hit to PF05496, RuvB_N, score 3.8e-18 936155001712 HMMPfam hit to PF00004, AAA, score 8.8e-33 936155001713 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001714 HMMPfam hit to PF05491, RuvB_C, score 3.7e-31 936155001715 NapD protein; Region: NapD; pfam03927 936155001716 ferredoxin-type protein; Provisional; Region: PRK10194 936155001717 HMMPfam hit to PF00037, Fer4, score 1.6e-05 936155001718 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155001719 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 936155001720 active site 936155001721 putative catalytic site [active] 936155001722 DNA binding site [nucleotide binding] 936155001723 putative phosphate binding site [ion binding]; other site 936155001724 metal binding site A [ion binding]; metal-binding site 936155001725 AP binding site [nucleotide binding]; other site 936155001726 metal binding site B [ion binding]; metal-binding site 936155001727 HMMPfam hit to PF03372, Exo_endo_phos, score 1.3e-64 936155001728 PS00728 AP endonucleases family 1 signature 3 936155001729 PS00727 AP endonucleases family 1 signature 2 936155001730 PS00726 AP endonucleases family 1 signature 1 936155001731 hypothetical protein; Provisional; Region: PRK10621 936155001732 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936155001733 6 probable transmembrane helices predicted for Hfelis04460 by TMHMM2.0 at aa 5-27, 75-97, 104-121, 150-172, 193-215 and 230-248 936155001734 HMMPfam hit to PF01925, DUF81, score 4.1e-48 936155001735 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001736 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 936155001737 metal ion-dependent adhesion site (MIDAS); other site 936155001738 regulatory ATPase RavA; Provisional; Region: PRK13531 936155001739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155001740 Walker A motif; other site 936155001741 ATP binding site [chemical binding]; other site 936155001742 Walker B motif; other site 936155001743 arginine finger; other site 936155001744 HMMPfam hit to PF07728, AAA_5, score 1.1e-34 936155001745 biotin synthase; Provisional; Region: PRK08508 936155001746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155001747 FeS/SAM binding site; other site 936155001748 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 936155001749 HMMPfam hit to PF04055, Radical_SAM, score 3.2e-22 936155001750 HMMPfam hit to PF06968, BATS, score 3.5e-19 936155001751 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 936155001752 HMMPfam hit to PF03631, Ribonuclease_BN, score 4e-17 936155001753 6 probable transmembrane helices predicted for Hfelis04510 by TMHMM2.0 at aa 48-70, 105-127, 147-169, 184-201, 213-235 and 250-272 936155001754 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 936155001755 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936155001756 tetramer interface [polypeptide binding]; other site 936155001757 catalytic Zn binding site [ion binding]; other site 936155001758 NADP binding site [chemical binding]; other site 936155001759 HMMPfam hit to PF08240, ADH_N, score 4.1e-14 936155001760 PS00059 Zinc-containing alcohol dehydrogenases signature 936155001761 HMMPfam hit to PF00107, ADH_zinc_N, score 6.7e-33 936155001762 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 936155001763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936155001764 HMMPfam hit to PF00070, Pyr_redox, score 1.6e-11 936155001765 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 936155001766 ligand binding site [chemical binding]; other site 936155001767 active site 936155001768 UGI interface [polypeptide binding]; other site 936155001769 catalytic site [active] 936155001770 HMMPfam hit to PF03167, UDG, score 1.9e-50 936155001771 carbon starvation protein A; Provisional; Region: PRK15015 936155001772 Carbon starvation protein CstA; Region: CstA; pfam02554 936155001773 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 936155001774 16 probable transmembrane helices predicted for Hfelis04570 by TMHMM2.0 at aa 7-26, 36-58, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 321-343, 363-385, 460-482, 511-533, 543-565, 572-594 and 640-662 936155001775 HMMPfam hit to PF02554, CstA, score 2.2e-267 936155001776 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001777 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001778 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 936155001779 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936155001780 active site 936155001781 HIGH motif; other site 936155001782 nucleotide binding site [chemical binding]; other site 936155001783 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936155001784 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 936155001785 active site 936155001786 KMSKS motif; other site 936155001787 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 936155001788 tRNA binding surface [nucleotide binding]; other site 936155001789 anticodon binding site; other site 936155001790 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 936155001791 HMMPfam hit to PF00133, tRNA-synt_1, score 1.5e-189 936155001792 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155001793 HMMPfam hit to PF08264, Anticodon_1, score 3.4e-33 936155001794 HMMPfam hit to PF10458, Val_tRNA-synt_C, score 1.9e-07 936155001795 signal recognition particle protein; Provisional; Region: PRK10867 936155001796 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 936155001797 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 936155001798 P loop; other site 936155001799 GTP binding site [chemical binding]; other site 936155001800 Signal peptide binding domain; Region: SRP_SPB; pfam02978 936155001801 HMMPfam hit to PF02881, SRP54_N, score 7e-14 936155001802 HMMPfam hit to PF00448, SRP54, score 3.8e-100 936155001803 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001804 PS00300 SRP54-type proteins GTP-binding domain signature 936155001805 HMMPfam hit to PF02978, SRP_SPB, score 9.8e-45 936155001806 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 936155001807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936155001808 catalytic residue [active] 936155001809 HMMPfam hit to PF00266, Aminotran_5, score 4.4e-08 936155001810 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site 936155001811 PS00626 Regulator of chromosome condensation (RCC1) signature 2 936155001812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155001813 active site 936155001814 HMMPfam hit to PF00156, Pribosyltran, score 1.3e-07 936155001815 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 936155001816 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936155001817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155001818 FeS/SAM binding site; other site 936155001819 HMMPfam hit to PF00919, UPF0004, score 8.5e-39 936155001820 HMMPfam hit to PF04055, Radical_SAM, score 4.1e-14 936155001821 PS01278 Uncharacterized protein family UPF0004 signature 936155001822 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155001823 1 probable transmembrane helix predicted for Hfelis04650 by TMHMM2.0 at aa 105-127 936155001824 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001825 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 936155001826 HMMPfam hit to PF03892, NapB, score 1.8e-10 936155001827 1 probable transmembrane helix predicted for Hfelis04660 by TMHMM2.0 at aa 7-24 936155001828 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 936155001829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155001830 FeS/SAM binding site; other site 936155001831 HMMPfam hit to PF04055, Radical_SAM, score 5.1e-06 936155001832 DNA topoisomerase I; Validated; Region: PRK05582 936155001833 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 936155001834 active site 936155001835 interdomain interaction site; other site 936155001836 putative metal-binding site [ion binding]; other site 936155001837 nucleotide binding site [chemical binding]; other site 936155001838 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 936155001839 domain I; other site 936155001840 DNA binding groove [nucleotide binding] 936155001841 phosphate binding site [ion binding]; other site 936155001842 domain II; other site 936155001843 domain III; other site 936155001844 nucleotide binding site [chemical binding]; other site 936155001845 catalytic site [active] 936155001846 domain IV; other site 936155001847 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936155001848 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936155001849 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936155001850 HMMPfam hit to PF01396, zf-C4_Topoisom, score 1.3e-15 936155001851 HMMPfam hit to PF01396, zf-C4_Topoisom, score 1.3e-17 936155001852 HMMPfam hit to PF01396, zf-C4_Topoisom, score 4.4e-20 936155001853 HMMPfam hit to PF01131, Topoisom_bac, score 4.9e-161 936155001854 PS00396 Prokaryotic DNA topoisomerase I active site 936155001855 HMMPfam hit to PF01751, Toprim, score 1.6e-26 936155001856 flagellin B; Provisional; Region: PRK13588 936155001857 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936155001858 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 936155001859 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 936155001860 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936155001861 HMMPfam hit to PF00669, Flagellin_N, score 3.9e-70 936155001862 HMMPfam hit to PF07196, Flagellin_IN, score 2.8e-10 936155001863 HMMPfam hit to PF07196, Flagellin_IN, score 8.8e-11 936155001864 HMMPfam hit to PF00700, Flagellin_C, score 7.6e-30 936155001865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 936155001866 HMMPfam hit to PF01973, DUF115, score 3.3e-55 936155001867 Uncharacterized conserved protein [Function unknown]; Region: COG4278 936155001868 Predicted helix-turn-helix motif with score 1574.000, SD 4.55 at aa 7-28, sequence YTQRDKARILKITTRTLQRWRY 936155001869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155001870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 936155001871 active site 936155001872 ATP binding site [chemical binding]; other site 936155001873 substrate binding site [chemical binding]; other site 936155001874 activation loop (A-loop); other site 936155001875 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 936155001876 metal ion-dependent adhesion site (MIDAS); other site 936155001877 HMMPfam hit to PF00092, VWA, score 1.4e-05 936155001878 Protein phosphatase 2C; Region: PP2C_2; pfam13672 936155001879 Protein phosphatase 2C; Region: PP2C_2; pfam13672 936155001880 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 936155001881 DEAD-like helicases superfamily; Region: DEXDc; smart00487 936155001882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936155001883 ATP binding site [chemical binding]; other site 936155001884 putative Mg++ binding site [ion binding]; other site 936155001885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936155001886 nucleotide binding region [chemical binding]; other site 936155001887 ATP-binding site [chemical binding]; other site 936155001888 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 936155001889 HMMPfam hit to PF03461, TRCF, score 2.6e-19 936155001890 HMMPfam hit to PF00271, Helicase_C, score 2.5e-16 936155001891 HMMPfam hit to PF00270, DEAD, score 3e-29 936155001892 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001893 HMMPfam hit to PF02559, CarD_TRCF, score 1.6e-32 936155001894 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 936155001895 HMMPfam hit to PF04519, DUF583, score 6.6e-17 936155001896 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936155001897 Peptidase family M23; Region: Peptidase_M23; pfam01551 936155001898 HMMPfam hit to PF01551, Peptidase_M23, score 7.2e-52 936155001899 1 probable transmembrane helix predicted for Hfelis04800 by TMHMM2.0 at aa 29-51 936155001900 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936155001901 Peptidase family M23; Region: Peptidase_M23; pfam01551 936155001902 HMMPfam hit to PF01551, Peptidase_M23, score 3.3e-31 936155001903 1 probable transmembrane helix predicted for Hfelis04810 by TMHMM2.0 at aa 26-48 936155001904 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 936155001905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936155001906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936155001907 HMMPfam hit to PF08245, Mur_ligase_M, score 0.001 936155001908 Lipopolysaccharide-assembly; Region: LptE; pfam04390 936155001909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001910 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 936155001911 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 936155001912 HIGH motif; other site 936155001913 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936155001914 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936155001915 active site 936155001916 KMSKS motif; other site 936155001917 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 936155001918 tRNA binding surface [nucleotide binding]; other site 936155001919 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001920 HMMPfam hit to PF09334, tRNA-synt_1g, score 2.7e-10 936155001921 HMMPfam hit to PF09334, tRNA-synt_1g, score 4e-13 936155001922 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155001923 4 probable transmembrane helices predicted for Hfelis04850 by TMHMM2.0 at aa 7-24, 29-48, 55-77 and 81-103 936155001924 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 936155001925 Protein export membrane protein; Region: SecD_SecF; pfam02355 936155001926 HMMPfam hit to PF02355, SecD_SecF, score 9.5e-79 936155001927 6 probable transmembrane helices predicted for Hfelis04860 by TMHMM2.0 at aa 13-35, 137-154, 161-180, 190-209, 244-266 and 270-292 936155001928 HMMPfam hit to PF07549, Sec_GG, score 8e-05 936155001929 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 936155001930 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 936155001931 HMMPfam hit to PF02355, SecD_SecF, score 4.4e-06 936155001932 6 probable transmembrane helices predicted for Hfelis04870 by TMHMM2.0 at aa 7-26, 351-373, 378-400, 404-426, 454-476 and 480-502 936155001933 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 936155001934 HMMPfam hit to PF02699, YajC, score 5.1e-36 936155001935 1 probable transmembrane helix predicted for Hfelis04880 by TMHMM2.0 at aa 7-26 936155001936 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 936155001937 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001938 12 probable transmembrane helices predicted for Hfelis04890 by TMHMM2.0 at aa 21-43, 63-81, 94-116, 126-148, 157-179, 184-201, 203-220, 225-242, 308-327, 337-359, 371-393 and 408-430 936155001939 HMMPfam hit to PF06965, Na_H_antiport_1, score 5.5e-209 936155001940 putative recombination protein RecB; Provisional; Region: PRK13909 936155001941 Part of AAA domain; Region: AAA_19; pfam13245 936155001942 Family description; Region: UvrD_C_2; pfam13538 936155001943 HMMPfam hit to PF00580, UvrD-helicase, score 3.8e-19 936155001944 HMMPfam hit to PF00580, UvrD-helicase, score 9.8e-20 936155001945 PS00017 ATP/GTP-binding site motif A (P-loop) 936155001946 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 936155001947 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 936155001948 active site 936155001949 intersubunit interface [polypeptide binding]; other site 936155001950 catalytic residue [active] 936155001951 HMMPfam hit to PF01081, Aldolase, score 8.9e-98 936155001952 PS00160 KDPG and KHG aldolases Schiff-base forming residue 936155001953 PS00159 KDPG and KHG aldolases active site 936155001954 6-phosphogluconate dehydratase; Region: edd; TIGR01196 936155001955 phosphogluconate dehydratase; Validated; Region: PRK09054 936155001956 HMMPfam hit to PF00920, ILVD_EDD, score 8.4e-259 936155001957 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2 936155001958 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1 936155001959 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 936155001960 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 936155001961 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 936155001962 HMMPfam hit to PF00479, G6PD_N, score 7.6e-76 936155001963 PS00069 Glucose-6-phosphate dehydrogenase active site 936155001964 HMMPfam hit to PF02781, G6PD_C, score 2.4e-84 936155001965 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 936155001966 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 936155001967 putative active site [active] 936155001968 glucokinase; Provisional; Region: glk; PRK00292 936155001969 glucokinase, proteobacterial type; Region: glk; TIGR00749 936155001970 HMMPfam hit to PF02685, Glucokinase, score 3.4e-165 936155001971 2 probable transmembrane helices predicted for Hfelis04950 by TMHMM2.0 at aa 251-273 and 294-313 936155001972 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 936155001973 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 936155001974 active site 936155001975 dimer interface [polypeptide binding]; other site 936155001976 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 936155001977 dimer interface [polypeptide binding]; other site 936155001978 active site 936155001979 PS00430 TonB-dependent receptor proteins signature 1 936155001980 HMMPfam hit to PF00342, PGI, score 3e-266 936155001981 PS00765 Phosphoglucose isomerase signature 1 936155001982 PS00174 Phosphoglucose isomerase signature 2 936155001983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936155001984 putative substrate translocation pore; other site 936155001985 glucose/galactose transporter; Region: gluP; TIGR01272 936155001986 12 probable transmembrane helices predicted for Hfelis04970 by TMHMM2.0 at aa 7-26, 46-63, 70-92, 102-124, 137-159, 174-196, 225-247, 262-279, 292-309, 313-335, 347-369 and 374-396 936155001987 HMMPfam hit to PF07690, MFS_1, score 4.3e-28 936155001988 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155001989 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 936155001990 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 936155001991 nucleotide binding pocket [chemical binding]; other site 936155001992 K-X-D-G motif; other site 936155001993 catalytic site [active] 936155001994 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 936155001995 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 936155001996 Dimer interface [polypeptide binding]; other site 936155001997 HMMPfam hit to PF00533, BRCT, score 3.5e-11 936155001998 HMMPfam hit to PF03120, DNA_ligase_OB, score 7e-35 936155001999 PS01056 NAD-dependent DNA ligase signature 2 936155002000 HMMPfam hit to PF01653, DNA_ligase_aden, score 6.5e-126 936155002001 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature 936155002002 PS01055 NAD-dependent DNA ligase signature 1 936155002003 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 936155002004 Response regulator receiver domain; Region: Response_reg; pfam00072 936155002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155002006 active site 936155002007 phosphorylation site [posttranslational modification] 936155002008 intermolecular recognition site; other site 936155002009 dimerization interface [polypeptide binding]; other site 936155002010 HMMPfam hit to PF01584, CheW, score 9.7e-20 936155002011 HMMPfam hit to PF00072, Response_reg, score 8.5e-19 936155002012 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 936155002013 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 936155002014 dimer interface [polypeptide binding]; other site 936155002015 anticodon binding site; other site 936155002016 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 936155002017 homodimer interface [polypeptide binding]; other site 936155002018 motif 1; other site 936155002019 active site 936155002020 motif 2; other site 936155002021 GAD domain; Region: GAD; pfam02938 936155002022 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936155002023 active site 936155002024 motif 3; other site 936155002025 HMMPfam hit to PF01336, tRNA_anti, score 1.1e-23 936155002026 HMMPfam hit to PF00152, tRNA-synt_2, score 3.8e-206 936155002027 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155002028 HMMPfam hit to PF02938, GAD, score 1.6e-30 936155002029 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 487-508, sequence ETQAKVFELLGISPQEAQEKFG 936155002030 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155002031 adenylate kinase; Reviewed; Region: adk; PRK00279 936155002032 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 936155002033 AMP-binding site [chemical binding]; other site 936155002034 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 936155002035 HMMPfam hit to PF00406, ADK, score 1e-39 936155002036 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002037 PS00113 Adenylate kinase signature 936155002038 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 936155002039 dimer interface [polypeptide binding]; other site 936155002040 substrate binding site [chemical binding]; other site 936155002041 metal binding sites [ion binding]; metal-binding site 936155002042 HMMPfam hit to PF00719, Pyrophosphatase, score 3.5e-61 936155002043 Protein of unknown function (DUF507); Region: DUF507; pfam04368 936155002044 HMMPfam hit to PF04368, DUF507, score 4.7e-92 936155002045 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 936155002046 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 936155002047 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 936155002048 catalytic site [active] 936155002049 subunit interface [polypeptide binding]; other site 936155002050 HMMPfam hit to PF00988, CPSase_sm_chain, score 5.7e-46 936155002051 HMMPfam hit to PF00117, GATase, score 2.3e-44 936155002052 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 936155002053 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 936155002054 HMMPfam hit to PF02684, LpxB, score 2.2e-104 936155002055 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 936155002056 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 936155002057 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 936155002058 HMMPfam hit to PF01155, HypA, score 7.9e-27 936155002059 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 936155002060 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936155002061 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 936155002062 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 936155002063 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936155002064 HMMPfam hit to PF06429, DUF1078, score 1e-18 936155002065 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002066 HMMPfam hit to PF07559, FlaE, score 4.3e-20 936155002067 HMMPfam hit to PF07196, Flagellin_IN, score 3e-11 936155002068 HMMPfam hit to PF00460, Flg_bb_rod, score 1.3e-12 936155002069 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 936155002070 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 936155002071 DHH family; Region: DHH; pfam01368 936155002072 HMMPfam hit to PF01368, DHH, score 3.7e-19 936155002073 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 936155002074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155002075 FeS/SAM binding site; other site 936155002076 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 936155002077 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002078 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 936155002079 HMMPfam hit to PF01975, SurE, score 5.9e-76 936155002080 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936155002081 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936155002082 substrate binding pocket [chemical binding]; other site 936155002083 chain length determination region; other site 936155002084 substrate-Mg2+ binding site; other site 936155002085 catalytic residues [active] 936155002086 aspartate-rich region 1; other site 936155002087 active site lid residues [active] 936155002088 aspartate-rich region 2; other site 936155002089 HMMPfam hit to PF00348, polyprenyl_synt, score 1.5e-55 936155002090 PS00444 Polyprenyl synthetases signature 2 936155002091 PDZ domain; Region: PDZ_2; pfam13180 936155002092 hypothetical protein; Provisional; Region: PRK03762 936155002093 HMMPfam hit to PF02575, DUF149, score 1e-26 936155002094 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 936155002095 tetramerization interface [polypeptide binding]; other site 936155002096 active site 936155002097 HMMPfam hit to PF02261, Asp_decarbox, score 8.1e-57 936155002098 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 936155002099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155002100 Walker A motif; other site 936155002101 ATP binding site [chemical binding]; other site 936155002102 Walker B motif; other site 936155002103 arginine finger; other site 936155002104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155002105 Walker A motif; other site 936155002106 ATP binding site [chemical binding]; other site 936155002107 Walker B motif; other site 936155002108 arginine finger; other site 936155002109 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 936155002110 HMMPfam hit to PF10431, ClpB_D2-small, score 2.2e-19 936155002111 HMMPfam hit to PF07724, AAA_2, score 3.7e-76 936155002112 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002113 HMMPfam hit to PF00004, AAA, score 1.9e-19 936155002114 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002115 HMMPfam hit to PF02861, Clp_N, score 2e-06 936155002116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936155002117 Ligand Binding Site [chemical binding]; other site 936155002118 HMMPfam hit to PF00582, Usp, score 1.9e-11 936155002119 AAA domain; Region: AAA_26; pfam13500 936155002120 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 936155002121 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 936155002122 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 936155002123 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 936155002124 HMMPfam hit to PF00081, Sod_Fe_N, score 5.2e-29 936155002125 HMMPfam hit to PF02777, Sod_Fe_C, score 1.3e-55 936155002126 PS00088 Manganese and iron superoxide dismutases signature 936155002127 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 936155002128 ThiS interaction site; other site 936155002129 putative active site [active] 936155002130 tetramer interface [polypeptide binding]; other site 936155002131 HMMPfam hit to PF05690, ThiG, score 1.2e-145 936155002132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155002133 S-adenosylmethionine binding site [chemical binding]; other site 936155002134 HMMPfam hit to PF08241, Methyltransf_11, score 4.2e-14 936155002135 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155002136 Sel1-like repeats; Region: SEL1; smart00671 936155002137 Sel1-like repeats; Region: SEL1; smart00671 936155002138 HMMPfam hit to PF08238, Sel1, score 0.00033 936155002139 HMMPfam hit to PF08238, Sel1, score 2.3 936155002140 HMMPfam hit to PF08238, Sel1, score 9.8e-06 936155002141 HMMPfam hit to PF08238, Sel1, score 1.3e-08 936155002142 HMMPfam hit to PF08238, Sel1, score 9.3e-12 936155002143 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 936155002144 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 936155002145 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 936155002146 HMMPfam hit to PF00926, DHBP_synthase, score 5.4e-118 936155002147 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 936155002148 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 936155002149 HMMPfam hit to PF01048, PNP_UDP_1, score 2.2e-55 936155002150 elongation factor Tu; Reviewed; Region: PRK00049 936155002151 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 936155002152 G1 box; other site 936155002153 GEF interaction site [polypeptide binding]; other site 936155002154 GTP/Mg2+ binding site [chemical binding]; other site 936155002155 Switch I region; other site 936155002156 G2 box; other site 936155002157 G3 box; other site 936155002158 Switch II region; other site 936155002159 G4 box; other site 936155002160 G5 box; other site 936155002161 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 936155002162 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 936155002163 Antibiotic Binding Site [chemical binding]; other site 936155002164 HMMPfam hit to PF00009, GTP_EFTU, score 1.1e-102 936155002165 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002166 PS00301 GTP-binding elongation factors signature 936155002167 HMMPfam hit to PF03144, GTP_EFTU_D2, score 3.3e-27 936155002168 HMMPfam hit to PF03143, GTP_EFTU_D3, score 2.2e-58 936155002169 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002170 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 936155002171 HMMPfam hit to PF00471, Ribosomal_L33, score 5.1e-17 936155002172 PS00582 Ribosomal protein L33 signature 936155002173 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 936155002174 1 probable transmembrane helix predicted for Hfelis05300 by TMHMM2.0 at aa 33-55 936155002175 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 936155002176 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 936155002177 putative homodimer interface [polypeptide binding]; other site 936155002178 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 936155002179 heterodimer interface [polypeptide binding]; other site 936155002180 homodimer interface [polypeptide binding]; other site 936155002181 HMMPfam hit to PF02357, NusG, score 1.4e-42 936155002182 HMMPfam hit to PF00467, KOW, score 4.3e-08 936155002183 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 936155002184 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 936155002185 23S rRNA interface [nucleotide binding]; other site 936155002186 L7/L12 interface [polypeptide binding]; other site 936155002187 putative thiostrepton binding site; other site 936155002188 L25 interface [polypeptide binding]; other site 936155002189 HMMPfam hit to PF03946, Ribosomal_L11_N, score 6e-33 936155002190 HMMPfam hit to PF00298, Ribosomal_L11, score 3.5e-28 936155002191 PS00359 Ribosomal protein L11 signature 936155002192 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 936155002193 mRNA/rRNA interface [nucleotide binding]; other site 936155002194 HMMPfam hit to PF00687, Ribosomal_L1, score 1.3e-116 936155002195 PS01199 Ribosomal protein L1 signature 936155002196 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 936155002197 23S rRNA interface [nucleotide binding]; other site 936155002198 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 936155002199 HMMPfam hit to PF00466, Ribosomal_L10, score 2.2e-22 936155002200 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 936155002201 core dimer interface [polypeptide binding]; other site 936155002202 peripheral dimer interface [polypeptide binding]; other site 936155002203 L10 interface [polypeptide binding]; other site 936155002204 L11 interface [polypeptide binding]; other site 936155002205 putative EF-Tu interaction site [polypeptide binding]; other site 936155002206 putative EF-G interaction site [polypeptide binding]; other site 936155002207 HMMPfam hit to PF00542, Ribosomal_L12, score 3.4e-33 936155002208 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 936155002209 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 936155002210 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 936155002211 RPB11 interaction site [polypeptide binding]; other site 936155002212 RPB12 interaction site [polypeptide binding]; other site 936155002213 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 936155002214 RPB1 interaction site [polypeptide binding]; other site 936155002215 RNA polymerase Rpb2, domain 7; Region: RNA_pol_Rpb2_7; pfam04560 936155002216 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 936155002217 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 936155002218 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 936155002219 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 936155002220 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 936155002221 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 936155002222 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 936155002223 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 936155002224 DNA binding site [nucleotide binding] 936155002225 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 936155002226 HMMPfam hit to PF04563, RNA_pol_Rpb2_1, score 9e-16 936155002227 HMMPfam hit to PF04561, RNA_pol_Rpb2_2, score 4.2e-16 936155002228 HMMPfam hit to PF04561, RNA_pol_Rpb2_2, score 8.3e-24 936155002229 HMMPfam hit to PF04565, RNA_pol_Rpb2_3, score 3e-42 936155002230 HMMPfam hit to PF10385, RNA_pol_Rpb2_45, score 2.4e-13 936155002231 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 936155002232 HMMPfam hit to PF00562, RNA_pol_Rpb2_6, score 1.9e-160 936155002233 PS01166 RNA polymerases beta chain signature 936155002234 HMMPfam hit to PF04560, RNA_pol_Rpb2_7, score 3.3e-46 936155002235 HMMPfam hit to PF04997, RNA_pol_Rpb1_1, score 4.7e-140 936155002236 HMMPfam hit to PF00623, RNA_pol_Rpb1_2, score 1.7e-82 936155002237 HMMPfam hit to PF04983, RNA_pol_Rpb1_3, score 2.7e-46 936155002238 HMMPfam hit to PF05000, RNA_pol_Rpb1_4, score 3.9e-29 936155002239 HMMPfam hit to PF04998, RNA_pol_Rpb1_5, score 3.6e-88 936155002240 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 936155002241 NusA N-terminal domain; Region: NusA_N; pfam08529 936155002242 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 936155002243 RNA binding site [nucleotide binding]; other site 936155002244 homodimer interface [polypeptide binding]; other site 936155002245 NusA-like KH domain; Region: KH_5; pfam13184 936155002246 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 936155002247 G-X-X-G motif; other site 936155002248 HMMPfam hit to PF08529, NusA_N, score 6.9e-05 936155002249 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 936155002250 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 936155002251 11 probable transmembrane helices predicted for Hfelis05390 by TMHMM2.0 at aa 20-42, 49-71, 96-118, 131-153, 168-190, 219-238, 248-270, 283-305, 320-339, 366-388 and 411-433 936155002252 HMMPfam hit to PF03605, DcuA_DcuB, score 2.4e-189 936155002253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002254 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 936155002255 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 936155002256 Domain of unknown function DUF87; Region: DUF87; pfam01935 936155002257 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 936155002258 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002259 HMMPfam hit to PF03135, CagE_TrbE_VirB, score 4.4e-52 936155002260 VirB8 protein; Region: VirB8; cl01500 936155002261 1 probable transmembrane helix predicted for Hfelis05410 by TMHMM2.0 at aa 56-78 936155002262 HMMPfam hit to PF04335, VirB8, score 2.5e-55 936155002263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002264 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 936155002265 6 probable transmembrane helices predicted for Hfelis05430 by TMHMM2.0 at aa 30-49, 62-80, 152-174, 181-203, 213-235 and 242-264 936155002266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002267 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155002268 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155002269 HMMPfam hit to PF08238, Sel1, score 0.00013 936155002270 HMMPfam hit to PF08238, Sel1, score 0.018 936155002271 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002272 1 probable transmembrane helix predicted for Hfelis05460 by TMHMM2.0 at aa 7-26 936155002273 Restriction endonuclease; Region: Mrr_cat; pfam04471 936155002274 TPR repeat; Region: TPR_11; pfam13414 936155002275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155002276 binding surface 936155002277 TPR motif; other site 936155002278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936155002279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155002280 TPR motif; other site 936155002281 binding surface 936155002282 HMMPfam hit to PF08238, Sel1, score 2.2e-10 936155002283 HMMPfam hit to PF08238, Sel1, score 3.2e-11 936155002284 HMMPfam hit to PF08238, Sel1, score 4e-11 936155002285 HMMPfam hit to PF08238, Sel1, score 5.2e-08 936155002286 GTPase CgtA; Reviewed; Region: obgE; PRK12299 936155002287 GTP1/OBG; Region: GTP1_OBG; pfam01018 936155002288 Obg GTPase; Region: Obg; cd01898 936155002289 G1 box; other site 936155002290 GTP/Mg2+ binding site [chemical binding]; other site 936155002291 Switch I region; other site 936155002292 G2 box; other site 936155002293 G3 box; other site 936155002294 Switch II region; other site 936155002295 G4 box; other site 936155002296 G5 box; other site 936155002297 HMMPfam hit to PF01926, MMR_HSR1, score 1.4e-39 936155002298 PS00905 GTP1/OBG family signature 936155002299 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002300 HMMPfam hit to PF01018, GTP1_OBG, score 2.5e-80 936155002301 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 936155002302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936155002303 Walker A/P-loop; other site 936155002304 ATP binding site [chemical binding]; other site 936155002305 Q-loop/lid; other site 936155002306 ABC transporter signature motif; other site 936155002307 Walker B; other site 936155002308 D-loop; other site 936155002309 H-loop/switch region; other site 936155002310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936155002311 HMMPfam hit to PF08352, oligo_HPY, score 2.7e-09 936155002312 HMMPfam hit to PF00005, ABC_tran, score 2.5e-64 936155002313 PS00211 ABC transporters family signature 936155002314 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 936155002316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936155002317 Walker A/P-loop; other site 936155002318 ATP binding site [chemical binding]; other site 936155002319 Q-loop/lid; other site 936155002320 ABC transporter signature motif; other site 936155002321 Walker B; other site 936155002322 D-loop; other site 936155002323 H-loop/switch region; other site 936155002324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936155002325 HMMPfam hit to PF08352, oligo_HPY, score 2.8e-16 936155002326 HMMPfam hit to PF00005, ABC_tran, score 3.7e-54 936155002327 PS00211 ABC transporters family signature 936155002328 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936155002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155002331 putative PBP binding loops; other site 936155002332 dimer interface [polypeptide binding]; other site 936155002333 ABC-ATPase subunit interface; other site 936155002334 HMMPfam hit to PF00528, BPD_transp_1, score 2.7e-39 936155002335 4 probable transmembrane helices predicted for Hfelis05520 by TMHMM2.0 at aa 9-26, 30-49, 79-101 and 134-156 936155002336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936155002337 2 probable transmembrane helices predicted for Hfelis05530 by TMHMM2.0 at aa 16-38 and 81-103 936155002338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936155002339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155002340 dimer interface [polypeptide binding]; other site 936155002341 conserved gate region; other site 936155002342 putative PBP binding loops; other site 936155002343 ABC-ATPase subunit interface; other site 936155002344 HMMPfam hit to PF00528, BPD_transp_1, score 5e-57 936155002345 6 probable transmembrane helices predicted for Hfelis05540 by TMHMM2.0 at aa 9-31, 100-122, 135-157, 200-217, 255-277 and 305-327 936155002346 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 936155002347 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 936155002348 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 936155002349 peptide binding site [polypeptide binding]; other site 936155002350 HMMPfam hit to PF00496, SBP_bac_5, score 6.6e-96 936155002351 PS00501 Signal peptidases I serine active site 936155002352 1 probable transmembrane helix predicted for Hfelis05550 by TMHMM2.0 at aa 7-29 936155002353 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 936155002354 HMMPfam hit to PF01016, Ribosomal_L27, score 5.5e-55 936155002355 PS00831 Ribosomal protein L27 signature 936155002356 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 936155002357 HMMPfam hit to PF00829, Ribosomal_L21p, score 3.1e-45 936155002358 PS01169 Ribosomal protein L21 signature 936155002359 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 936155002360 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936155002361 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936155002362 Sulfatase; Region: Sulfatase; cl17466 936155002363 HMMPfam hit to PF00884, Sulfatase, score 2.3e-40 936155002364 5 probable transmembrane helices predicted for Hfelis05590 by TMHMM2.0 at aa 21-43, 74-93, 100-122, 151-173 and 180-202 936155002365 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 936155002366 HMMPfam hit to PF05211, NLBH, score 4e-87 936155002367 1 probable transmembrane helix predicted for Hfelis05600 by TMHMM2.0 at aa 7-29 936155002368 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002369 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 936155002370 dimer interface [polypeptide binding]; other site 936155002371 putative active site [active] 936155002372 trimer interface [polypeptide binding]; other site 936155002373 HMMPfam hit to PF01967, MoaC, score 1.5e-73 936155002374 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 936155002375 MPT binding site; other site 936155002376 trimer interface [polypeptide binding]; other site 936155002377 HMMPfam hit to PF00994, MoCF_biosynth, score 6.7e-37 936155002378 PS01078 Molybdenum cofactor biosynthesis proteins signature 1 936155002379 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 936155002380 MoaE homodimer interface [polypeptide binding]; other site 936155002381 MoaD interaction [polypeptide binding]; other site 936155002382 active site residues [active] 936155002383 HMMPfam hit to PF02391, MoaE, score 2.8e-05 936155002384 charged pocket; other site 936155002385 ThiS family; Region: ThiS; pfam02597 936155002386 hydrophobic patch; other site 936155002387 HMMPfam hit to PF02597, ThiS, score 4.7e-19 936155002388 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 936155002389 dimerization interface [polypeptide binding]; other site 936155002390 active site 936155002391 HMMPfam hit to PF00925, GTP_cyclohydro2, score 2.1e-84 936155002392 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 936155002393 3 probable transmembrane helices predicted for Hfelis05660 by TMHMM2.0 at aa 12-34, 67-89 and 150-172 936155002394 Domain of unknown function (DUF386); Region: DUF386; cl01047 936155002395 HMMPfam hit to PF04074, DUF386, score 2.2e-07 936155002396 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 936155002397 HMMPfam hit to PF09917, DUF2147, score 1.2e-18 936155002398 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 936155002399 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936155002400 HMMPfam hit to PF02774, Semialdhyde_dhC, score 8.4e-71 936155002401 PS01103 Aspartate-semialdehyde dehydrogenase signature 936155002402 HMMPfam hit to PF01118, Semialdhyde_dh, score 2.6e-45 936155002403 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 936155002404 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 936155002405 dimer interface [polypeptide binding]; other site 936155002406 motif 1; other site 936155002407 active site 936155002408 motif 2; other site 936155002409 motif 3; other site 936155002410 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 936155002411 anticodon binding site; other site 936155002412 HMMPfam hit to PF03129, HGTP_anticodon, score 1e-15 936155002413 HMMPfam hit to PF00587, tRNA-synt_2b, score 9.6e-36 936155002414 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155002415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 936155002416 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 936155002417 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155002418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936155002419 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155002420 dimer interface [polypeptide binding]; other site 936155002421 putative CheW interface [polypeptide binding]; other site 936155002422 HMMPfam hit to PF00015, MCPsignal, score 1.3e-29 936155002423 HMMPfam hit to PF00672, HAMP, score 1.4e-06 936155002424 2 probable transmembrane helices predicted for Hfelis05710 by TMHMM2.0 at aa 10-32 and 209-231 936155002425 PS00041 Bacterial regulatory proteins, araC family signature 936155002426 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 936155002427 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 936155002428 catalytic triad [active] 936155002429 HMMPfam hit to PF00578, AhpC-TSA, score 8.1e-55 936155002430 Uncharacterized conserved protein [Function unknown]; Region: COG1556 936155002431 HMMPfam hit to PF02589, DUF162, score 2.4e-24 936155002432 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 936155002433 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 936155002434 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936155002435 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 936155002436 HMMPfam hit to PF00037, Fer4, score 3.5e-05 936155002437 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155002438 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155002439 HMMPfam hit to PF02589, DUF162, score 3.1e-42 936155002440 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936155002441 Cysteine-rich domain; Region: CCG; pfam02754 936155002442 Cysteine-rich domain; Region: CCG; pfam02754 936155002443 HMMPfam hit to PF02754, CCG, score 1.3e-18 936155002444 HMMPfam hit to PF02754, CCG, score 4.4e-14 936155002445 Cache domain; Region: Cache_1; pfam02743 936155002446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936155002447 dimerization interface [polypeptide binding]; other site 936155002448 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155002449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155002450 dimer interface [polypeptide binding]; other site 936155002451 putative CheW interface [polypeptide binding]; other site 936155002452 2 probable transmembrane helices predicted for Hfelis05760 by TMHMM2.0 at aa 20-42 and 287-309 936155002453 HMMPfam hit to PF02743, Cache_1, score 2.4e-11 936155002454 HMMPfam hit to PF00672, HAMP, score 6.8e-15 936155002455 HMMPfam hit to PF00015, MCPsignal, score 4.9e-36 936155002456 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 936155002457 HMMPfam hit to PF09982, DUF2219, score 3.4e-66 936155002458 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155002459 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936155002460 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 936155002461 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936155002462 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936155002463 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936155002464 Surface antigen; Region: Bac_surface_Ag; pfam01103 936155002465 HMMPfam hit to PF07244, Surf_Ag_VNR, score 1.9e-13 936155002466 HMMPfam hit to PF07244, Surf_Ag_VNR, score 5.2e-12 936155002467 HMMPfam hit to PF07244, Surf_Ag_VNR, score 7.9e-05 936155002468 HMMPfam hit to PF07244, Surf_Ag_VNR, score 1.3e-10 936155002469 HMMPfam hit to PF07244, Surf_Ag_VNR, score 2.6e-18 936155002470 HMMPfam hit to PF01103, Bac_surface_Ag, score 3.1e-52 936155002471 hypothetical protein; Provisional; Region: PRK08445 936155002472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155002473 FeS/SAM binding site; other site 936155002474 HMMPfam hit to PF04055, Radical_SAM, score 1.8e-23 936155002475 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936155002476 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936155002477 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936155002478 HMMPfam hit to PF00675, Peptidase_M16, score 0.033 936155002479 HMMPfam hit to PF05193, Peptidase_M16_C, score 3.5e-25 936155002480 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 936155002481 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 936155002482 GatB domain; Region: GatB_Yqey; smart00845 936155002483 HMMPfam hit to PF02934, GatB_N, score 2.4e-155 936155002484 PS01234 PET112 family signature 936155002485 HMMPfam hit to PF01162, GatB, score 2.3e-24 936155002486 HMMPfam hit to PF02637, GatB_Yqey, score 5.1e-49 936155002487 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002488 PS00092 N-6 Adenine-specific DNA methylases signature 936155002489 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 936155002490 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 936155002491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155002492 HMMPfam hit to PF00534, Glycos_transf_1, score 4.5e-22 936155002493 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 936155002494 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 936155002495 9 probable transmembrane helices predicted for Hfelis05850 by TMHMM2.0 at aa 4-25, 32-54, 69-91, 121-143, 180-199, 218-237, 291-313, 334-356 and 403-424 936155002496 HMMPfam hit to PF02386, TrkH, score 1.8e-90 936155002497 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 936155002498 TrkA-N domain; Region: TrkA_N; pfam02254 936155002499 HMMPfam hit to PF02254, TrkA_N, score 8.4e-28 936155002500 HMMPfam hit to PF02080, TrkA_C, score 1.2e-05 936155002501 putative acyltransferase; Provisional; Region: PRK05790 936155002502 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936155002503 dimer interface [polypeptide binding]; other site 936155002504 active site 936155002505 HMMPfam hit to PF00108, Thiolase_N, score 1.5e-104 936155002506 PS00098 Thiolases acyl-enzyme intermediate signature 936155002507 HMMPfam hit to PF02803, Thiolase_C, score 6.6e-64 936155002508 PS00737 Thiolases signature 2 936155002509 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 936155002510 HMMPfam hit to PF01144, CoA_trans, score 9.1e-103 936155002511 PS01273 CoA transferases signature 1 936155002512 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 936155002513 HMMPfam hit to PF01144, CoA_trans, score 1e-54 936155002514 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 936155002515 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 936155002516 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 936155002517 HMMPfam hit to PF05378, Hydant_A_N, score 1.9e-13 936155002518 HMMPfam hit to PF01968, Hydantoinase_A, score 4.3e-75 936155002519 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 936155002520 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 936155002521 HMMPfam hit to PF08882, Acetone_carb_G, score 5.2e-70 936155002522 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 936155002523 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 936155002524 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 936155002525 HMMPfam hit to PF05378, Hydant_A_N, score 1.4e-45 936155002526 HMMPfam hit to PF01968, Hydantoinase_A, score 3.8e-76 936155002527 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 936155002528 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 936155002529 HMMPfam hit to PF02538, Hydantoinase_B, score 8.1e-13 936155002530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002531 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 936155002532 HMMPfam hit to PF09499, RE_ApaLI, score 1e-10 936155002533 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 936155002534 HMMPfam hit to PF09499, RE_ApaLI, score 1.4e-30 936155002535 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155002536 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155002537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155002538 S-adenosylmethionine binding site [chemical binding]; other site 936155002539 HMMPfam hit to PF01555, N6_N4_Mtase, score 8.8e-39 936155002540 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002541 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 936155002542 HMMPfam hit to PF05211, NLBH, score 9.1e-39 936155002543 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002544 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 936155002545 HMMPfam hit to PF01648, ACPS, score 5.5e-19 936155002546 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 936155002547 HMMPfam hit to PF03748, FliL, score 1.7e-44 936155002548 2 probable transmembrane helices predicted for Hfelis06010 by TMHMM2.0 at aa 13-35 and 79-98 936155002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 936155002550 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 936155002551 HMMPfam hit to PF03602, Cons_hypoth95, score 1.7e-37 936155002552 PS00092 N-6 Adenine-specific DNA methylases signature 936155002553 GTP-binding protein LepA; Provisional; Region: PRK05433 936155002554 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 936155002555 G1 box; other site 936155002556 putative GEF interaction site [polypeptide binding]; other site 936155002557 GTP/Mg2+ binding site [chemical binding]; other site 936155002558 Switch I region; other site 936155002559 G2 box; other site 936155002560 G3 box; other site 936155002561 Switch II region; other site 936155002562 G4 box; other site 936155002563 G5 box; other site 936155002564 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 936155002565 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 936155002566 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 936155002567 HMMPfam hit to PF00009, GTP_EFTU, score 3.9e-73 936155002568 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002569 PS00301 GTP-binding elongation factors signature 936155002570 HMMPfam hit to PF03144, GTP_EFTU_D2, score 4.8e-10 936155002571 HMMPfam hit to PF00679, EFG_C, score 1.3e-32 936155002572 HMMPfam hit to PF06421, LepA_C, score 2.8e-75 936155002573 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 936155002574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155002575 Walker A motif; other site 936155002576 ATP binding site [chemical binding]; other site 936155002577 Walker B motif; other site 936155002578 HMMPfam hit to PF07724, AAA_2, score 1.5e-13 936155002579 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002580 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 936155002581 MutS domain III; Region: MutS_III; pfam05192 936155002582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155002583 Walker A/P-loop; other site 936155002584 ATP binding site [chemical binding]; other site 936155002585 Q-loop/lid; other site 936155002586 ABC transporter signature motif; other site 936155002587 Walker B; other site 936155002588 D-loop; other site 936155002589 H-loop/switch region; other site 936155002590 Smr domain; Region: Smr; pfam01713 936155002591 HMMPfam hit to PF01713, Smr, score 1.8e-23 936155002592 HMMPfam hit to PF00488, MutS_V, score 3.7e-05 936155002593 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002594 2 probable transmembrane helices predicted for Hfelis06070 by TMHMM2.0 at aa 2-24 and 30-48 936155002595 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 936155002596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936155002597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936155002598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936155002599 HMMPfam hit to PF02875, Mur_ligase_C, score 5.4e-15 936155002600 HMMPfam hit to PF08245, Mur_ligase_M, score 4.4e-07 936155002601 HMMPfam hit to PF01225, Mur_ligase, score 2.1e-30 936155002602 hypothetical protein; Provisional; Region: PRK05839 936155002603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936155002604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155002605 homodimer interface [polypeptide binding]; other site 936155002606 catalytic residue [active] 936155002607 HMMPfam hit to PF00155, Aminotran_1_2, score 8.7e-18 936155002608 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002609 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 936155002610 GIY-YIG motif/motif A; other site 936155002611 active site 936155002612 catalytic site [active] 936155002613 putative DNA binding site [nucleotide binding]; other site 936155002614 metal binding site [ion binding]; metal-binding site 936155002615 UvrB/uvrC motif; Region: UVR; pfam02151 936155002616 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 936155002617 HMMPfam hit to PF01541, GIY-YIG, score 2.9e-19 936155002618 HMMPfam hit to PF08459, UvrC_HhH_N, score 5.6e-56 936155002619 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site 936155002620 nickel responsive regulator; Provisional; Region: PRK00630 936155002621 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 936155002622 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 936155002623 HMMPfam hit to PF01402, RHH_1, score 2e-10 936155002624 HMMPfam hit to PF08753, NikR_C, score 1.4e-32 936155002625 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 936155002626 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 936155002627 active site 936155002628 (T/H)XGH motif; other site 936155002629 HMMPfam hit to PF01467, CTP_transf_2, score 1.9e-33 936155002630 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 936155002631 HMMPfam hit to PF02410, DUF143, score 1.1e-27 936155002632 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 936155002633 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 936155002634 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002635 HMMPfam hit to PF01715, IPPT, score 2.8e-75 936155002636 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 936155002637 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 936155002638 active site 936155002639 zinc binding site [ion binding]; other site 936155002640 HMMPfam hit to PF00194, Carb_anhydrase, score 4.9e-17 936155002641 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 936155002642 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 936155002643 dimerization interface [polypeptide binding]; other site 936155002644 DPS ferroxidase diiron center [ion binding]; other site 936155002645 ion pore; other site 936155002646 HMMPfam hit to PF00210, Ferritin, score 5e-22 936155002647 PS00819 Dps protein family signature 2 936155002648 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 936155002649 HMMPfam hit to PF09442, DUF2018, score 4.3e-18 936155002650 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936155002651 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936155002652 substrate binding pocket [chemical binding]; other site 936155002653 chain length determination region; other site 936155002654 substrate-Mg2+ binding site; other site 936155002655 catalytic residues [active] 936155002656 aspartate-rich region 1; other site 936155002657 active site lid residues [active] 936155002658 aspartate-rich region 2; other site 936155002659 HMMPfam hit to PF00348, polyprenyl_synt, score 3.7e-33 936155002660 PS00444 Polyprenyl synthetases signature 2 936155002661 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 936155002662 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 936155002663 tRNA; other site 936155002664 putative tRNA binding site [nucleotide binding]; other site 936155002665 putative NADP binding site [chemical binding]; other site 936155002666 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 936155002667 HMMPfam hit to PF05201, GlutR_N, score 1.7e-41 936155002668 HMMPfam hit to PF01488, Shikimate_DH, score 5.8e-36 936155002669 HMMPfam hit to PF00745, GlutR_dimer, score 9.6e-18 936155002670 prolyl-tRNA synthetase; Provisional; Region: PRK09194 936155002671 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 936155002672 dimer interface [polypeptide binding]; other site 936155002673 motif 1; other site 936155002674 active site 936155002675 motif 2; other site 936155002676 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 936155002677 putative deacylase active site [active] 936155002678 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936155002679 active site 936155002680 motif 3; other site 936155002681 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 936155002682 anticodon binding site; other site 936155002683 HMMPfam hit to PF00587, tRNA-synt_2b, score 4.2e-56 936155002684 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155002685 HMMPfam hit to PF04073, YbaK, score 1e-24 936155002686 HMMPfam hit to PF03129, HGTP_anticodon, score 2.3e-19 936155002687 HMMPfam hit to PF04186, FxsA, score 3e-05 936155002688 2 probable transmembrane helices predicted for Hfelis06230 by TMHMM2.0 at aa 7-29 and 73-95 936155002689 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 936155002690 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 936155002691 domain interfaces; other site 936155002692 active site 936155002693 HMMPfam hit to PF01379, Porphobil_deam, score 2.4e-104 936155002694 HMMPfam hit to PF03900, Porphobil_deamC, score 6.8e-19 936155002695 PS00533 Porphobilinogen deaminase cofactor-binding site 936155002696 Sulfatase; Region: Sulfatase; pfam00884 936155002697 HMMPfam hit to PF00884, Sulfatase, score 4.1e-47 936155002698 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002699 1 probable transmembrane helix predicted for Hfelis06250 by TMHMM2.0 at aa 13-32 936155002700 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 936155002701 4 probable transmembrane helices predicted for Hfelis06260 by TMHMM2.0 at aa 12-34, 44-66, 73-95 and 115-137 936155002702 HMMPfam hit to PF08019, DUF1705, score 5.2e-07 936155002703 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 936155002704 dimer interface [polypeptide binding]; other site 936155002705 Citrate synthase; Region: Citrate_synt; pfam00285 936155002706 active site 936155002707 citrylCoA binding site [chemical binding]; other site 936155002708 NADH binding [chemical binding]; other site 936155002709 cationic pore residues; other site 936155002710 oxalacetate/citrate binding site [chemical binding]; other site 936155002711 coenzyme A binding site [chemical binding]; other site 936155002712 catalytic triad [active] 936155002713 HMMPfam hit to PF00285, Citrate_synt, score 1.2e-152 936155002714 PS00480 Citrate synthase signature 936155002715 isocitrate dehydrogenase; Validated; Region: PRK07362 936155002716 isocitrate dehydrogenase; Reviewed; Region: PRK07006 936155002717 HMMPfam hit to PF00180, Iso_dh, score 3e-148 936155002718 PS00470 Isocitrate and isopropylmalate dehydrogenases signature 936155002719 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936155002720 8 probable transmembrane helices predicted for Hfelis06290 by TMHMM2.0 at aa 5-27, 34-56, 76-94, 101-120, 157-188, 195-217, 227-249 and 256-275 936155002721 HMMPfam hit to PF01925, DUF81, score 9.4e-30 936155002722 Cache domain; Region: Cache_1; pfam02743 936155002723 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 936155002724 dimerization interface [polypeptide binding]; other site 936155002725 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155002726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155002727 dimer interface [polypeptide binding]; other site 936155002728 putative CheW interface [polypeptide binding]; other site 936155002729 HMMPfam hit to PF00015, MCPsignal, score 4e-30 936155002730 HMMPfam hit to PF00672, HAMP, score 5.2e-07 936155002731 2 probable transmembrane helices predicted for Hfelis06310 by TMHMM2.0 at aa 22-44 and 290-312 936155002732 HMMPfam hit to PF02743, Cache_1, score 1.5e-09 936155002733 3 probable transmembrane helices predicted for Hfelis06320 by TMHMM2.0 at aa 29-51, 263-285 and 295-317 936155002734 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 936155002735 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936155002736 Walker A/P-loop; other site 936155002737 ATP binding site [chemical binding]; other site 936155002738 Q-loop/lid; other site 936155002739 ABC transporter signature motif; other site 936155002740 Walker B; other site 936155002741 D-loop; other site 936155002742 H-loop/switch region; other site 936155002743 HMMPfam hit to PF00005, ABC_tran, score 8.7e-29 936155002744 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002745 6 probable transmembrane helices predicted for Hfelis06340 by TMHMM2.0 at aa 13-31, 46-68, 102-124, 150-172, 179-201 and 226-248 936155002746 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 936155002747 HMMPfam hit to PF01474, DAHP_synth_2, score 6.9e-261 936155002748 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 936155002749 RuvA N terminal domain; Region: RuvA_N; pfam01330 936155002750 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 936155002751 HMMPfam hit to PF07499, RuvA_C, score 2.3e-10 936155002752 HMMPfam hit to PF01330, RuvA_N, score 5.9e-12 936155002753 Protein of unknown function (DUF342); Region: DUF342; pfam03961 936155002754 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 936155002755 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 936155002756 12 probable transmembrane helices predicted for Hfelis06400 by TMHMM2.0 at aa 34-53, 87-109, 129-151, 156-178, 198-220, 255-277, 281-300, 321-343, 363-385, 398-415, 419-441 and 454-476 936155002757 HMMPfam hit to PF03023, MVIN, score 9.7e-123 936155002758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002759 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936155002760 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 936155002761 active site 936155002762 HIGH motif; other site 936155002763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936155002764 KMSKS motif; other site 936155002765 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 936155002766 tRNA binding surface [nucleotide binding]; other site 936155002767 anticodon binding site; other site 936155002768 HMMPfam hit to PF01406, tRNA-synt_1e, score 3.8e-162 936155002769 AIR carboxylase; Region: AIRC; pfam00731 936155002770 HMMPfam hit to PF00731, AIRC, score 5e-80 936155002771 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 936155002772 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 936155002773 ATP binding site [chemical binding]; other site 936155002774 active site 936155002775 substrate binding site [chemical binding]; other site 936155002776 HMMPfam hit to PF01259, SAICAR_synt, score 4.8e-93 936155002777 PS01057 SAICAR synthetase signature 1 936155002778 PS01058 SAICAR synthetase signature 2 936155002779 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 936155002780 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 936155002781 active site 936155002782 tetramer interface [polypeptide binding]; other site 936155002783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155002784 active site 936155002785 PS00443 Glutamine amidotransferases class-II active site 936155002786 HMMPfam hit to PF00310, GATase_2, score 1e-21 936155002787 HMMPfam hit to PF00156, Pribosyltran, score 3.9e-12 936155002788 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 936155002789 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 936155002790 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 936155002791 dimerization interface [polypeptide binding]; other site 936155002792 putative ATP binding site [chemical binding]; other site 936155002793 HMMPfam hit to PF00586, AIRS, score 8.7e-32 936155002794 HMMPfam hit to PF02769, AIRS_C, score 4.4e-40 936155002795 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 936155002796 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 936155002797 HMMPfam hit to PF01808, AICARFT_IMPCHas, score 8e-106 936155002798 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 936155002799 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 936155002800 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 936155002801 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 936155002802 HMMPfam hit to PF02844, GARS_N, score 7.8e-29 936155002803 HMMPfam hit to PF01071, GARS_A, score 1.3e-101 936155002804 PS00184 Phosphoribosylglycinamide synthetase signature 936155002805 HMMPfam hit to PF02843, GARS_C, score 1.9e-15 936155002806 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 936155002807 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 936155002808 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 936155002809 dimerization interface [polypeptide binding]; other site 936155002810 ATP binding site [chemical binding]; other site 936155002811 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 936155002812 dimerization interface [polypeptide binding]; other site 936155002813 ATP binding site [chemical binding]; other site 936155002814 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 936155002815 conserved cys residue [active] 936155002816 HMMPfam hit to PF02769, AIRS_C, score 1.9e-24 936155002817 PS00881 Protein splicing signature 936155002818 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155002819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155002820 dimer interface [polypeptide binding]; other site 936155002821 putative CheW interface [polypeptide binding]; other site 936155002822 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 936155002823 2 probable transmembrane helices predicted for Hfelis06500 by TMHMM2.0 at aa 12-31 and 317-339 936155002824 HMMPfam hit to PF00015, MCPsignal, score 8.5e-36 936155002825 transcription termination factor Rho; Provisional; Region: rho; PRK09376 936155002826 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 936155002827 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 936155002828 RNA binding site [nucleotide binding]; other site 936155002829 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 936155002830 multimer interface [polypeptide binding]; other site 936155002831 Walker A motif; other site 936155002832 ATP binding site [chemical binding]; other site 936155002833 Walker B motif; other site 936155002834 HMMPfam hit to PF07498, Rho_N, score 2.1e-16 936155002835 HMMPfam hit to PF07497, Rho_RNA_bind, score 1.3e-42 936155002836 HMMPfam hit to PF00006, ATP-synt_ab, score 3.3e-74 936155002837 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002838 glutamate racemase; Provisional; Region: PRK00865 936155002839 HMMPfam hit to PF01177, Asp_Glu_race, score 1.8e-69 936155002840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002841 PS00924 Aspartate and glutamate racemases signature 2 936155002842 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 936155002843 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 936155002844 active site 936155002845 homodimer interface [polypeptide binding]; other site 936155002846 HMMPfam hit to PF04101, Glyco_tran_28_C, score 2.6e-39 936155002847 HMMPfam hit to PF03033, Glyco_transf_28, score 1.2e-28 936155002848 FliW protein; Region: FliW; cl00740 936155002849 HMMPfam hit to PF02623, FliW, score 1.6e-30 936155002850 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 936155002851 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 936155002852 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 936155002853 HMMPfam hit to PF06518, DUF1104, score 1e-10 936155002854 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 936155002855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 936155002856 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 936155002857 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155002858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936155002859 dimerization interface [polypeptide binding]; other site 936155002860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155002861 dimer interface [polypeptide binding]; other site 936155002862 putative CheW interface [polypeptide binding]; other site 936155002863 2 probable transmembrane helices predicted for Hfelis06580 by TMHMM2.0 at aa 4-26 and 207-229 936155002864 HMMPfam hit to PF08269, Cache_2, score 0.0013 936155002865 HMMPfam hit to PF00672, HAMP, score 1.1e-08 936155002866 HMMPfam hit to PF00015, MCPsignal, score 6.2e-37 936155002867 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 936155002868 active site 936155002869 putative DNA-binding cleft [nucleotide binding]; other site 936155002870 dimer interface [polypeptide binding]; other site 936155002871 HMMPfam hit to PF02075, RuvC, score 2.8e-67 936155002872 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 936155002873 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 936155002874 active site 936155002875 HMMPfam hit to PF02152, FolB, score 1.9e-18 936155002876 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 936155002877 HMMPfam hit to PF02660, DUF205, score 1.6e-60 936155002878 5 probable transmembrane helices predicted for Hfelis06620 by TMHMM2.0 at aa 10-32, 98-116, 126-148, 155-177 and 192-214 936155002879 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936155002880 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 936155002881 active site 936155002882 4 probable transmembrane helices predicted for Hfelis06640 by TMHMM2.0 at aa 20-42, 77-99, 140-159 and 163-185 936155002883 HMMPfam hit to PF01569, PAP2, score 9.2e-11 936155002884 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002885 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 936155002886 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 936155002887 putative acyl-acceptor binding pocket; other site 936155002888 HMMPfam hit to PF03279, Lip_A_acyltrans, score 5.4e-91 936155002889 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 936155002890 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 936155002891 putative active site [active] 936155002892 HMMPfam hit to PF01075, Glyco_transf_9, score 1e-45 936155002893 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 936155002894 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 936155002895 HMMPfam hit to PF02541, Ppx-GppA, score 1.1e-90 936155002896 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 936155002897 HMMPfam hit to PF00037, Fer4, score 6.2e-05 936155002898 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155002899 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155002900 HMMPfam hit to PF01856, HP_OMP, score 1.3e-42 936155002901 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 936155002902 trimer interface [polypeptide binding]; other site 936155002903 active site 936155002904 HMMPfam hit to PF00692, dUTPase, score 0.0028 936155002905 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 936155002906 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936155002907 carboxyltransferase (CT) interaction site; other site 936155002908 biotinylation site [posttranslational modification]; other site 936155002909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155002910 HMMPfam hit to PF00364, Biotin_lipoyl, score 3.8e-20 936155002911 biotin carboxylase; Validated; Region: PRK08462 936155002912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936155002913 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936155002914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936155002915 HMMPfam hit to PF00289, CPSase_L_chain, score 2.7e-38 936155002916 HMMPfam hit to PF02786, CPSase_L_D2, score 3.3e-102 936155002917 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 936155002918 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 936155002919 HMMPfam hit to PF02785, Biotin_carb_C, score 8.6e-71 936155002920 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 936155002921 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 936155002922 dimer interface [polypeptide binding]; other site 936155002923 PYR/PP interface [polypeptide binding]; other site 936155002924 TPP binding site [chemical binding]; other site 936155002925 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936155002926 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 936155002927 TPP-binding site [chemical binding]; other site 936155002928 dimer interface [polypeptide binding]; other site 936155002929 HMMPfam hit to PF02775, TPP_enzyme_C, score 4.2e-15 936155002930 HMMPfam hit to PF00205, TPP_enzyme_M, score 6.2e-24 936155002931 HMMPfam hit to PF02776, TPP_enzyme_N, score 5.5e-61 936155002932 peptide chain release factor 1; Validated; Region: prfA; PRK00591 936155002933 This domain is found in peptide chain release factors; Region: PCRF; smart00937 936155002934 RF-1 domain; Region: RF-1; pfam00472 936155002935 HMMPfam hit to PF00472, RF-1, score 2.5e-73 936155002936 PS00745 Prokaryotic-type class I peptide chain release factors signature 936155002937 HMMPfam hit to PF03462, PCRF, score 6.7e-59 936155002938 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 936155002939 HMMPfam hit to PF01649, Ribosomal_S20p, score 4.3e-38 936155002940 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 936155002941 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 936155002942 active site 936155002943 substrate binding site [chemical binding]; other site 936155002944 metal binding site [ion binding]; metal-binding site 936155002945 HMMPfam hit to PF02878, PGM_PMM_I, score 1.8e-57 936155002946 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature 936155002947 HMMPfam hit to PF02879, PGM_PMM_II, score 6.8e-43 936155002948 HMMPfam hit to PF02880, PGM_PMM_III, score 9e-36 936155002949 HMMPfam hit to PF00408, PGM_PMM_IV, score 5e-07 936155002950 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 936155002951 HMMPfam hit to PF01252, Peptidase_A8, score 1.4e-45 936155002952 4 probable transmembrane helices predicted for Hfelis06810 by TMHMM2.0 at aa 5-27, 51-73, 85-104 and 119-138 936155002953 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 936155002954 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 936155002955 active site 936155002956 HMMPfam hit to PF01844, HNH, score 2.7e-08 936155002957 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155002958 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155002959 HMMPfam hit to PF01555, N6_N4_Mtase, score 6.3e-57 936155002960 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 936155002961 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 936155002962 CoA-binding site [chemical binding]; other site 936155002963 ATP-binding [chemical binding]; other site 936155002964 HMMPfam hit to PF01121, CoaE, score 6.2e-41 936155002965 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 936155002967 HMMPfam hit to PF01564, Spermine_synth, score 5.5e-13 936155002968 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 936155002969 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 936155002970 HMMPfam hit to PF01019, G_glu_transpept, score 4.7e-254 936155002971 PS00462 Gamma-glutamyltranspeptidase signature 936155002972 1 probable transmembrane helix predicted for Hfelis06880 by TMHMM2.0 at aa 7-29 936155002973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155002974 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 936155002975 Walker A motif; other site 936155002976 ATP binding site [chemical binding]; other site 936155002977 Walker B motif; other site 936155002978 arginine finger; other site 936155002979 HMMPfam hit to PF00004, AAA, score 1.4e-12 936155002980 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002981 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 936155002982 HMMPfam hit to PF02367, UPF0079, score 2.9e-10 936155002983 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002984 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 936155002985 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 936155002986 Walker A/P-loop; other site 936155002987 ATP binding site [chemical binding]; other site 936155002988 Q-loop/lid; other site 936155002989 ABC transporter signature motif; other site 936155002990 Walker B; other site 936155002991 D-loop; other site 936155002992 H-loop/switch region; other site 936155002993 HMMPfam hit to PF00005, ABC_tran, score 8.2e-61 936155002994 PS00017 ATP/GTP-binding site motif A (P-loop) 936155002995 PS00211 ABC transporters family signature 936155002996 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 936155002997 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 936155002998 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 936155002999 PS00430 TonB-dependent receptor proteins signature 1 936155003000 HMMPfam hit to PF04963, Sigma54_CBD, score 5.4e-09 936155003001 HMMPfam hit to PF04552, Sigma54_DBD, score 2.9e-64 936155003002 PS00717 Sigma-54 factors family signature 1 936155003003 Predicted helix-turn-helix motif with score 1866.000, SD 5.54 at aa 312-333, sequence MRLVDIANEFGYSTSTISRAIA 936155003004 PS00718 Sigma-54 factors family signature 2 936155003005 Sel1-like repeats; Region: SEL1; smart00671 936155003006 HMMPfam hit to PF08238, Sel1, score 7e-05 936155003007 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 936155003008 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 936155003009 motif 1; other site 936155003010 active site 936155003011 motif 2; other site 936155003012 motif 3; other site 936155003013 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 936155003014 HMMPfam hit to PF01411, tRNA-synt_2c, score 6.8e-240 936155003015 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155003016 HMMPfam hit to PF07973, tRNA_SAD, score 4.4e-16 936155003017 HMMPfam hit to PF03597, CcoS, score 1.2e-15 936155003018 1 probable transmembrane helix predicted for Hfelis06960 by TMHMM2.0 at aa 6-28 936155003019 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 936155003020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936155003021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936155003022 HMMPfam hit to PF07992, Pyr_redox_2, score 4.2e-11 936155003023 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 936155003024 substrate binding site [chemical binding]; other site 936155003025 HMMPfam hit to PF01161, PBP, score 1.1e-30 936155003026 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 936155003027 HMMPfam hit to PF07977, FabA, score 2.1e-54 936155003028 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 936155003029 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 936155003030 active site 936155003031 HMMPfam hit to PF00132, Hexapep, score 8.4 936155003032 PS00101 Hexapeptide-repeat containing-transferases signature 936155003033 HMMPfam hit to PF00132, Hexapep, score 2.2 936155003034 HMMPfam hit to PF00132, Hexapep, score 6.2 936155003035 HMMPfam hit to PF00132, Hexapep, score 44 936155003036 HMMPfam hit to PF00132, Hexapep, score 8.1 936155003037 HMMPfam hit to PF00132, Hexapep, score 0.11 936155003038 PS00101 Hexapeptide-repeat containing-transferases signature 936155003039 HMMPfam hit to PF00132, Hexapep, score 26 936155003040 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 936155003041 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 936155003042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155003043 Walker A motif; other site 936155003044 ATP binding site [chemical binding]; other site 936155003045 Walker B motif; other site 936155003046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936155003047 HMMPfam hit to PF07724, AAA_2, score 2.3e-83 936155003048 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003049 HMMPfam hit to PF10431, ClpB_D2-small, score 2.8e-13 936155003050 rod shape-determining protein MreB; Provisional; Region: PRK13927 936155003051 MreB and similar proteins; Region: MreB_like; cd10225 936155003052 nucleotide binding site [chemical binding]; other site 936155003053 Mg binding site [ion binding]; other site 936155003054 putative protofilament interaction site [polypeptide binding]; other site 936155003055 RodZ interaction site [polypeptide binding]; other site 936155003056 HMMPfam hit to PF06723, MreB_Mbl, score 1e-203 936155003057 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003058 rod shape-determining protein MreC; Region: MreC; pfam04085 936155003059 1 probable transmembrane helix predicted for Hfelis07030 by TMHMM2.0 at aa 7-29 936155003060 HMMPfam hit to PF04085, MreC, score 2.3e-15 936155003061 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 936155003062 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 936155003063 HMMPfam hit to PF00496, SBP_bac_5, score 1.9e-79 936155003064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936155003065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155003066 dimer interface [polypeptide binding]; other site 936155003067 conserved gate region; other site 936155003068 putative PBP binding loops; other site 936155003069 ABC-ATPase subunit interface; other site 936155003070 6 probable transmembrane helices predicted for Hfelis07050 by TMHMM2.0 at aa 13-35, 106-128, 148-170, 190-209, 251-273 and 293-315 936155003071 HMMPfam hit to PF00528, BPD_transp_1, score 3.3e-42 936155003072 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936155003073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155003074 ABC-ATPase subunit interface; other site 936155003075 putative PBP binding loops; other site 936155003076 6 probable transmembrane helices predicted for Hfelis07060 by TMHMM2.0 at aa 7-29, 68-87, 100-122, 127-149, 188-210 and 230-252 936155003077 HMMPfam hit to PF00528, BPD_transp_1, score 8.4e-14 936155003078 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 936155003079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155003080 Walker A/P-loop; other site 936155003081 ATP binding site [chemical binding]; other site 936155003082 Q-loop/lid; other site 936155003083 ABC transporter signature motif; other site 936155003084 Walker B; other site 936155003085 D-loop; other site 936155003086 H-loop/switch region; other site 936155003087 HMMPfam hit to PF00005, ABC_tran, score 1e-35 936155003088 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936155003090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936155003091 Walker A/P-loop; other site 936155003092 ATP binding site [chemical binding]; other site 936155003093 Q-loop/lid; other site 936155003094 ABC transporter signature motif; other site 936155003095 Walker B; other site 936155003096 D-loop; other site 936155003097 H-loop/switch region; other site 936155003098 HMMPfam hit to PF00005, ABC_tran, score 2.1e-47 936155003099 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003100 PS00211 ABC transporters family signature 936155003101 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 936155003102 HMMPfam hit to PF10117, McrBC, score 4.5e-108 936155003103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936155003104 HMMPfam hit to PF07728, AAA_5, score 1.2e-13 936155003105 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003106 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936155003107 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936155003108 dimer interface [polypeptide binding]; other site 936155003109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155003110 catalytic residue [active] 936155003111 HMMPfam hit to PF00291, PALP, score 3.2e-103 936155003112 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site 936155003113 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 936155003114 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936155003115 homodimer interface [polypeptide binding]; other site 936155003116 substrate-cofactor binding pocket; other site 936155003117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155003118 catalytic residue [active] 936155003119 HMMPfam hit to PF01053, Cys_Met_Meta_PP, score 4.2e-238 936155003120 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site 936155003121 S-ribosylhomocysteinase; Provisional; Region: PRK02260 936155003122 HMMPfam hit to PF02664, LuxS, score 7.6e-98 936155003123 selenocysteine synthase; Provisional; Region: PRK04311 936155003124 HMMPfam hit to PF03841, SelA, score 1.2e-05 936155003125 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003126 HMMPfam hit to PF01856, HP_OMP, score 7.2e-18 936155003127 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936155003128 HMMPfam hit to PF03841, SelA, score 8.7e-21 936155003129 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 936155003130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155003131 S-adenosylmethionine binding site [chemical binding]; other site 936155003132 HMMPfam hit to PF02353, CMAS, score 5.7e-161 936155003133 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 936155003134 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 936155003135 active site 936155003136 HIGH motif; other site 936155003137 KMSKS motif; other site 936155003138 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 936155003139 tRNA binding surface [nucleotide binding]; other site 936155003140 anticodon binding site; other site 936155003141 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 936155003142 dimer interface [polypeptide binding]; other site 936155003143 putative tRNA-binding site [nucleotide binding]; other site 936155003144 HMMPfam hit to PF09334, tRNA-synt_1g, score 1.1e-188 936155003145 HMMPfam hit to PF01588, tRNA_bind, score 1.2e-36 936155003146 Methyltransferase domain; Region: Methyltransf_31; pfam13847 936155003147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155003148 S-adenosylmethionine binding site [chemical binding]; other site 936155003149 HMMPfam hit to PF08003, Methyltransf_9, score 4.4e-54 936155003150 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 936155003151 active site 2 [active] 936155003152 active site 1 [active] 936155003153 1 probable transmembrane helix predicted for Hfelis07240 by TMHMM2.0 at aa 48-67 936155003154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155003155 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 936155003156 putative ADP-binding pocket [chemical binding]; other site 936155003157 HMMPfam hit to PF00534, Glycos_transf_1, score 1.1e-21 936155003158 PS00215 Mitochondrial energy transfer proteins signature 936155003159 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 936155003160 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 936155003161 HMMPfam hit to PF03548, LolA, score 3.5e-27 936155003162 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 936155003163 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 936155003164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936155003165 nucleotide binding region [chemical binding]; other site 936155003166 ATP-binding site [chemical binding]; other site 936155003167 SEC-C motif; Region: SEC-C; pfam02810 936155003168 HMMPfam hit to PF07517, SecA_DEAD, score 8.8e-181 936155003169 HMMPfam hit to PF01043, SecA_PP_bind, score 8.2e-67 936155003170 PS01312 Protein secA signatures 936155003171 HMMPfam hit to PF07516, SecA_SW, score 9.6e-85 936155003172 HMMPfam hit to PF02810, SEC-C, score 3.6e-08 936155003173 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 936155003174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936155003175 FtsX-like permease family; Region: FtsX; pfam02687 936155003176 4 probable transmembrane helices predicted for Hfelis07280 by TMHMM2.0 at aa 22-44, 275-297, 322-356 and 371-393 936155003177 HMMPfam hit to PF02687, FtsX, score 6.8e-22 936155003178 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 936155003179 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 936155003180 HMMPfam hit to PF00076, RRM_1, score 1e-22 936155003181 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 936155003182 hypothetical protein; Provisional; Region: PRK05834 936155003183 intersubunit interface [polypeptide binding]; other site 936155003184 active site 936155003185 Zn2+ binding site [ion binding]; other site 936155003186 HMMPfam hit to PF00596, Aldolase_II, score 1.1e-12 936155003187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155003188 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 936155003189 Walker A/P-loop; other site 936155003190 ATP binding site [chemical binding]; other site 936155003191 Q-loop/lid; other site 936155003192 ABC transporter signature motif; other site 936155003193 Walker B; other site 936155003194 D-loop; other site 936155003195 H-loop/switch region; other site 936155003196 HMMPfam hit to PF00005, ABC_tran, score 1.2e-49 936155003197 PS00211 ABC transporters family signature 936155003198 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003199 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 936155003200 putative heme binding pocket [chemical binding]; other site 936155003201 Integral membrane protein TerC family; Region: TerC; cl10468 936155003202 9 probable transmembrane helices predicted for Hfelis07330 by TMHMM2.0 at aa 5-22, 35-54, 64-86, 99-121, 125-144, 214-236, 251-273, 285-307 and 311-333 936155003203 HMMPfam hit to PF03741, TerC, score 1e-79 936155003204 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003205 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 936155003206 Ligand Binding Site [chemical binding]; other site 936155003207 HMMPfam hit to PF01171, ATP_bind_3, score 8.7e-13 936155003208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936155003209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936155003210 putative substrate translocation pore; other site 936155003211 12 probable transmembrane helices predicted for Hfelis07350 by TMHMM2.0 at aa 5-27, 37-59, 72-94, 99-118, 131-153, 157-174, 201-223, 238-260, 267-286, 296-318, 331-353 and 363-382 936155003212 HMMPfam hit to PF07690, MFS_1, score 1.8e-61 936155003213 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003214 1 probable transmembrane helix predicted for Hfelis07360 by TMHMM2.0 at aa 15-32 936155003215 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 936155003216 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 936155003217 tandem repeat interface [polypeptide binding]; other site 936155003218 oligomer interface [polypeptide binding]; other site 936155003219 active site residues [active] 936155003220 2 probable transmembrane helices predicted for Hfelis07370 by TMHMM2.0 at aa 15-34 and 128-150 936155003221 HMMPfam hit to PF01343, Peptidase_S49, score 3.8e-56 936155003222 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003223 HMMPfam hit to PF01856, HP_OMP, score 1.9e-77 936155003224 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003225 HMMPfam hit to PF01856, HP_OMP, score 9.7e-43 936155003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 936155003227 4 probable transmembrane helices predicted for Hfelis07400 by TMHMM2.0 at aa 7-29, 56-78, 90-107 and 122-144 936155003228 HMMPfam hit to PF04323, DUF474, score 4.3e-39 936155003229 S-methylmethionine transporter; Provisional; Region: PRK11387 936155003230 HMMPfam hit to PF00324, AA_permease, score 1.1e-124 936155003231 12 probable transmembrane helices predicted for Hfelis07410 by TMHMM2.0 at aa 21-43, 48-70, 91-113, 128-145, 158-180, 210-232, 251-273, 307-329, 349-371, 375-397, 420-442 and 447-466 936155003232 PS00218 Amino acid permeases signature 936155003233 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 936155003234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936155003235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936155003236 protein binding site [polypeptide binding]; other site 936155003237 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936155003238 protein binding site [polypeptide binding]; other site 936155003239 HMMPfam hit to PF00089, Trypsin, score 9.5e-21 936155003240 HMMPfam hit to PF00595, PDZ, score 1.3e-08 936155003241 Transglycosylase; Region: Transgly; pfam00912 936155003242 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 936155003243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936155003244 HMMPfam hit to PF00905, Transpeptidase, score 1.7e-34 936155003245 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003246 HMMPfam hit to PF00912, Transgly, score 3.9e-79 936155003247 1 probable transmembrane helix predicted for Hfelis07430 by TMHMM2.0 at aa 9-31 936155003248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155003249 dimer interface [polypeptide binding]; other site 936155003250 putative CheW interface [polypeptide binding]; other site 936155003251 HMMPfam hit to PF00015, MCPsignal, score 1e-31 936155003252 HMMPfam hit to PF00672, HAMP, score 0.0063 936155003253 3 probable transmembrane helices predicted for Hfelis07440 by TMHMM2.0 at aa 7-29, 177-196 and 304-326 936155003254 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 936155003255 putative CheA interaction surface; other site 936155003256 HMMPfam hit to PF01584, CheW, score 4.5e-22 936155003257 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936155003258 putative binding surface; other site 936155003259 active site 936155003260 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 936155003261 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 936155003262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155003263 ATP binding site [chemical binding]; other site 936155003264 Mg2+ binding site [ion binding]; other site 936155003265 G-X-G motif; other site 936155003266 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 936155003267 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 936155003268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155003269 active site 936155003270 phosphorylation site [posttranslational modification] 936155003271 intermolecular recognition site; other site 936155003272 dimerization interface [polypeptide binding]; other site 936155003273 HMMPfam hit to PF00072, Response_reg, score 2e-25 936155003274 PS00217 Sugar transport proteins signature 2 936155003275 HMMPfam hit to PF01584, CheW, score 7.4e-24 936155003276 HMMPfam hit to PF02518, HATPase_c, score 1.2e-28 936155003277 HMMPfam hit to PF02895, H-kinase_dim, score 2.9e-28 936155003278 HMMPfam hit to PF01627, Hpt, score 1.3e-12 936155003279 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 936155003280 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 936155003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155003282 active site 936155003283 phosphorylation site [posttranslational modification] 936155003284 intermolecular recognition site; other site 936155003285 dimerization interface [polypeptide binding]; other site 936155003286 HMMPfam hit to PF00072, Response_reg, score 8.8e-15 936155003287 HMMPfam hit to PF01584, CheW, score 4.5e-22 936155003288 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 936155003289 putative active site [active] 936155003290 putative metal binding site [ion binding]; other site 936155003291 PS00019 Actinin-type actin-binding domain signature 1 936155003292 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 936155003293 thiS-thiF/thiG interaction site; other site 936155003294 HMMPfam hit to PF02597, ThiS, score 7.6e-23 936155003295 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 936155003296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936155003297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 936155003298 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 936155003299 active site 936155003300 HMMPfam hit to PF00478, IMPDH, score 4.2e-230 936155003301 PS00487 IMP dehydrogenase / GMP reductase signature 936155003302 HMMPfam hit to PF00571, CBS, score 1.8e-30 936155003303 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 936155003304 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 936155003305 HMMPfam hit to PF01425, Amidase, score 9.4e-171 936155003306 PS00571 Amidases signature 936155003307 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003308 HMMPfam hit to PF01856, HP_OMP, score 2.3e-38 936155003309 Protein of unknown function (DUF511); Region: DUF511; cl01114 936155003310 HMMPfam hit to PF04373, DUF511, score 1.4e-41 936155003311 Pantoate-beta-alanine ligase; Region: PanC; cd00560 936155003312 pantoate--beta-alanine ligase; Region: panC; TIGR00018 936155003313 active site 936155003314 ATP-binding site [chemical binding]; other site 936155003315 pantoate-binding site; other site 936155003316 HXXH motif; other site 936155003317 HMMPfam hit to PF02569, Pantoate_ligase, score 3.5e-145 936155003318 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 936155003319 active site 936155003320 dimer interface [polypeptide binding]; other site 936155003321 HMMPfam hit to PF00215, OMPdecase, score 1.3e-58 936155003322 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 936155003323 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 936155003324 HMMPfam hit to PF00793, DAHP_synth_1, score 6.7e-70 936155003325 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 936155003326 homopentamer interface [polypeptide binding]; other site 936155003327 active site 936155003328 HMMPfam hit to PF00885, DMRL_synthase, score 1.1e-71 936155003329 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 936155003330 putative RNA binding site [nucleotide binding]; other site 936155003331 HMMPfam hit to PF01029, NusB, score 6.5e-42 936155003332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936155003333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936155003334 putative substrate translocation pore; other site 936155003335 12 probable transmembrane helices predicted for Hfelis07590 by TMHMM2.0 at aa 7-29, 49-68, 75-97, 102-124, 131-153, 158-180, 201-223, 238-257, 264-283, 293-312, 332-354 and 358-380 936155003336 HMMPfam hit to PF07690, MFS_1, score 4.7e-36 936155003337 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003338 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003339 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003340 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 936155003341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936155003342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936155003343 ABC transporter; Region: ABC_tran_2; pfam12848 936155003344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936155003345 HMMPfam hit to PF00005, ABC_tran, score 4.1e-39 936155003346 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003347 HMMPfam hit to PF00005, ABC_tran, score 5.7e-38 936155003348 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003349 5 probable transmembrane helices predicted for Hfelis07610 by TMHMM2.0 at aa 13-35, 42-59, 63-80, 111-133 and 143-165 936155003350 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 936155003351 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936155003352 putative active site [active] 936155003353 putative metal binding site [ion binding]; other site 936155003354 4 probable transmembrane helices predicted for Hfelis07620 by TMHMM2.0 at aa 5-23, 30-52, 67-89 and 111-133 936155003355 HMMPfam hit to PF00149, Metallophos, score 4.6e-14 936155003356 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature 936155003357 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003358 HMMPfam hit to PF01856, HP_OMP, score 6.5e-50 936155003359 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003360 HMMPfam hit to PF01856, HP_OMP, score 4.9e-53 936155003361 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 936155003362 tetramer interfaces [polypeptide binding]; other site 936155003363 binuclear metal-binding site [ion binding]; other site 936155003364 HMMPfam hit to PF04608, PgpA, score 2.1e-47 936155003365 4 probable transmembrane helices predicted for Hfelis07650 by TMHMM2.0 at aa 20-38, 43-60, 80-102 and 123-145 936155003366 phosphoserine phosphatase SerB; Region: serB; TIGR00338 936155003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936155003368 motif II; other site 936155003369 HMMPfam hit to PF00702, Hydrolase, score 3.4e-25 936155003370 PS00430 TonB-dependent receptor proteins signature 1 936155003371 T5orf172 domain; Region: T5orf172; pfam10544 936155003372 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 936155003373 HMMPfam hit to PF10544, T5orf172, score 1.3e-09 936155003374 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 936155003375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936155003376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936155003377 HMMPfam hit to PF00905, Transpeptidase, score 1.3e-47 936155003378 HMMPfam hit to PF03717, PBP_dimer, score 2e-34 936155003379 1 probable transmembrane helix predicted for Hfelis07680 by TMHMM2.0 at aa 7-29 936155003380 4 probable transmembrane helices predicted for Hfelis07690 by TMHMM2.0 at aa 9-26, 31-46, 59-88 and 108-130 936155003381 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 936155003382 G1 box; other site 936155003383 GTP/Mg2+ binding site [chemical binding]; other site 936155003384 Switch I region; other site 936155003385 G2 box; other site 936155003386 G3 box; other site 936155003387 Switch II region; other site 936155003388 G4 box; other site 936155003389 HMMPfam hit to PF01926, MMR_HSR1, score 1.2e-23 936155003390 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003391 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 936155003392 OstA-like protein; Region: OstA; pfam03968 936155003393 HMMPfam hit to PF03968, OstA, score 1.6e-23 936155003394 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 936155003395 rare lipoprotein A; Region: rlpA; TIGR00413 936155003396 Sporulation related domain; Region: SPOR; pfam05036 936155003397 HMMPfam hit to PF05036, SPOR, score 1.4e-11 936155003398 HMMPfam hit to PF03330, DPBB_1, score 1.1e-43 936155003399 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003400 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936155003401 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936155003402 catalytic residue [active] 936155003403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936155003404 HMMPfam hit to PF01476, LysM, score 4.8e-12 936155003405 HMMPfam hit to PF01464, SLT, score 4.7e-29 936155003406 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 936155003407 active site 936155003408 HMMPfam hit to PF01026, TatD_DNase, score 1.8e-100 936155003409 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 936155003410 Lumazine binding domain; Region: Lum_binding; pfam00677 936155003411 Lumazine binding domain; Region: Lum_binding; pfam00677 936155003412 HMMPfam hit to PF00677, Lum_binding, score 7.2e-07 936155003413 HMMPfam hit to PF00677, Lum_binding, score 4.9e-20 936155003414 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 936155003415 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 936155003416 pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844 936155003417 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 936155003418 HMMPfam hit to PF01558, POR, score 1.8e-56 936155003419 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 936155003420 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936155003421 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155003422 HMMPfam hit to PF00037, Fer4, score 5.2e-08 936155003423 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155003424 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 936155003425 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 936155003426 dimer interface [polypeptide binding]; other site 936155003427 PYR/PP interface [polypeptide binding]; other site 936155003428 TPP binding site [chemical binding]; other site 936155003429 substrate binding site [chemical binding]; other site 936155003430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936155003431 HMMPfam hit to PF01855, POR_N, score 2.4e-102 936155003432 PS00099 Thiolases active site 936155003433 HMMPfam hit to PF02780, Transketolase_C, score 5.6e-06 936155003434 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 936155003435 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 936155003436 TPP-binding site [chemical binding]; other site 936155003437 putative dimer interface [polypeptide binding]; other site 936155003438 HMMPfam hit to PF02775, TPP_enzyme_C, score 1.5e-28 936155003439 adenylosuccinate lyase; Provisional; Region: PRK08470 936155003440 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 936155003441 tetramer interface [polypeptide binding]; other site 936155003442 active site 936155003443 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 936155003444 HMMPfam hit to PF00206, Lyase_1, score 6.6e-36 936155003445 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003446 PS00163 Fumarate lyases signature 936155003447 HMMPfam hit to PF10397, ADSL_C, score 9.5e-26 936155003448 Flagellin N-methylase; Region: FliB; pfam03692 936155003449 HMMPfam hit to PF03692, UPF0153, score 1.1e-14 936155003450 1 probable transmembrane helix predicted for Hfelis07870 by TMHMM2.0 at aa 5-27 936155003451 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 936155003452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155003453 Walker A motif; other site 936155003454 ATP binding site [chemical binding]; other site 936155003455 Walker B motif; other site 936155003456 arginine finger; other site 936155003457 HMMPfam hit to PF00004, AAA, score 6.5e-35 936155003458 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003459 1 probable transmembrane helix predicted for Hfelis07910 by TMHMM2.0 at aa 4-22 936155003460 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 936155003461 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 936155003462 Ligand Binding Site [chemical binding]; other site 936155003463 HMMPfam hit to PF03054, tRNA_Me_trans, score 2.5e-157 936155003464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 936155003465 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 936155003466 HMMPfam hit to PF09903, DUF2130, score 2.9e-82 936155003467 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 936155003468 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 936155003469 HMMPfam hit to PF03264, Cytochrom_NNT, score 2e-13 936155003470 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003471 1 probable transmembrane helix predicted for Hfelis07950 by TMHMM2.0 at aa 13-35 936155003472 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 936155003473 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 936155003474 L-lactate transport; Region: lctP; TIGR00795 936155003475 14 probable transmembrane helices predicted for Hfelis07970 by TMHMM2.0 at aa 15-34, 41-58, 73-95, 116-135, 140-162, 169-191, 195-217, 224-241, 251-269, 294-316, 364-386, 407-429, 444-466 and 525-547 936155003476 HMMPfam hit to PF02652, Lactate_perm, score 0 936155003477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003478 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936155003479 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936155003480 HMMPfam hit to PF01594, UPF0118, score 8.7e-43 936155003481 8 probable transmembrane helices predicted for Hfelis07980 by TMHMM2.0 at aa 5-22, 27-46, 53-75, 149-171, 192-214, 224-246, 259-278 and 313-335 936155003482 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 936155003483 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936155003484 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936155003485 HMMPfam hit to PF01678, DAP_epimerase, score 4.7e-23 936155003486 PS01326 Diaminopimelate epimerase signature 936155003487 HMMPfam hit to PF01678, DAP_epimerase, score 8.8e-11 936155003488 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003489 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155003490 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155003491 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.4e-87 936155003492 PS00092 N-6 Adenine-specific DNA methylases signature 936155003493 2 probable transmembrane helices predicted for Hfelis08020 by TMHMM2.0 at aa 29-51 and 55-77 936155003494 TrbC/VIRB2 family; Region: TrbC; pfam04956 936155003495 3 probable transmembrane helices predicted for Hfelis08030 by TMHMM2.0 at aa 5-27, 38-55 and 62-84 936155003496 1 probable transmembrane helix predicted for Hfelis08040 by TMHMM2.0 at aa 32-54 936155003497 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003498 HMMPfam hit to PF01856, HP_OMP, score 1.8e-44 936155003499 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003500 HMMPfam hit to PF01856, HP_OMP, score 0.00025 936155003501 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 936155003502 HMMPfam hit to PF00873, ACR_tran, score 0 936155003503 12 probable transmembrane helices predicted for Hfelis08070 by TMHMM2.0 at aa 13-35, 327-344, 351-373, 379-401, 422-444, 459-481, 509-531, 843-865, 872-891, 901-923, 944-966 and 976-998 936155003504 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936155003505 HlyD family secretion protein; Region: HlyD_3; pfam13437 936155003506 HMMPfam hit to PF00529, HlyD, score 0.00037 936155003507 Outer membrane efflux protein; Region: OEP; pfam02321 936155003508 Outer membrane efflux protein; Region: OEP; pfam02321 936155003509 HMMPfam hit to PF02321, OEP, score 1.3e-29 936155003510 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936155003512 IHF dimer interface [polypeptide binding]; other site 936155003513 IHF - DNA interface [nucleotide binding]; other site 936155003514 HMMPfam hit to PF00216, Bac_DNA_binding, score 1.3e-22 936155003515 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 936155003516 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 936155003517 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 936155003518 HMMPfam hit to PF00044, Gp_dh_N, score 5.3e-84 936155003519 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site 936155003520 HMMPfam hit to PF02800, Gp_dh_C, score 3.7e-73 936155003521 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 936155003522 Phosphoglycerate kinase; Region: PGK; pfam00162 936155003523 substrate binding site [chemical binding]; other site 936155003524 hinge regions; other site 936155003525 ADP binding site [chemical binding]; other site 936155003526 catalytic site [active] 936155003527 HMMPfam hit to PF00162, PGK, score 1.6e-160 936155003528 PS00111 Phosphoglycerate kinase signature 936155003529 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 936155003530 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 936155003531 oligomer interface [polypeptide binding]; other site 936155003532 HMMPfam hit to PF01544, CorA, score 1.7e-60 936155003533 2 probable transmembrane helices predicted for Hfelis08130 by TMHMM2.0 at aa 257-279 and 289-311 936155003534 3 probable transmembrane helices predicted for Hfelis08140 by TMHMM2.0 at aa 13-35, 128-150 and 157-176 936155003535 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature 936155003536 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 936155003537 HMMPfam hit to PF03738, GSP_synth, score 9.3e-189 936155003538 hypothetical protein; Provisional; Region: PRK04081 936155003539 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 936155003541 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155003542 HAMP domain; Region: HAMP; pfam00672 936155003543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155003544 dimer interface [polypeptide binding]; other site 936155003545 putative CheW interface [polypeptide binding]; other site 936155003546 HMMPfam hit to PF00015, MCPsignal, score 7.5e-35 936155003547 HMMPfam hit to PF00672, HAMP, score 6.9e-10 936155003548 2 probable transmembrane helices predicted for Hfelis08170 by TMHMM2.0 at aa 4-26 and 204-226 936155003549 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 936155003550 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 936155003551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936155003552 HMMPfam hit to PF00672, HAMP, score 1.5e-09 936155003553 1 probable transmembrane helix predicted for Hfelis08190 by TMHMM2.0 at aa 188-210 936155003554 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936155003555 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 936155003556 active site 936155003557 HMMPfam hit to PF01569, PAP2, score 4.4e-19 936155003558 1 probable transmembrane helix predicted for Hfelis08200 by TMHMM2.0 at aa 150-169 936155003559 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 936155003560 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 936155003561 Mg++ binding site [ion binding]; other site 936155003562 putative catalytic motif [active] 936155003563 substrate binding site [chemical binding]; other site 936155003564 10 probable transmembrane helices predicted for Hfelis08210 by TMHMM2.0 at aa 2-24, 44-75, 88-107, 117-135, 140-159, 163-180, 185-207, 211-233, 265-287 and 292-314 936155003565 HMMPfam hit to PF00953, Glycos_transf_4, score 6.1e-08 936155003566 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 936155003567 active site 936155003568 hydrophilic channel; other site 936155003569 dimerization interface [polypeptide binding]; other site 936155003570 catalytic residues [active] 936155003571 active site lid [active] 936155003572 HMMPfam hit to PF03740, PdxJ, score 1.3e-98 936155003573 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 936155003574 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 936155003575 HMMPfam hit to PF04166, PdxA, score 3.6e-74 936155003576 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 936155003577 HMMPfam hit to PF03061, 4HBT, score 6.7e-13 936155003578 Protein of unknown function (DUF535); Region: DUF535; cl01128 936155003579 HMMPfam hit to PF04393, DUF535, score 5.2e-12 936155003580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003581 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 936155003582 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 936155003583 NAD binding site [chemical binding]; other site 936155003584 homodimer interface [polypeptide binding]; other site 936155003585 active site 936155003586 substrate binding site [chemical binding]; other site 936155003587 HMMPfam hit to PF01370, Epimerase, score 1.6e-53 936155003588 short chain dehydrogenase; Validated; Region: PRK06182 936155003589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936155003590 NAD(P) binding site [chemical binding]; other site 936155003591 active site 936155003592 HMMPfam hit to PF00106, adh_short, score 1.6e-14 936155003593 Predicted permease [General function prediction only]; Region: COG2056 936155003594 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 936155003595 10 probable transmembrane helices predicted for Hfelis08290 by TMHMM2.0 at aa 21-43, 63-85, 98-120, 142-164, 185-207, 246-268, 280-302, 327-349, 356-378 and 407-429 936155003596 HMMPfam hit to PF03553, Na_H_antiporter, score 1.3e-72 936155003597 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003598 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 936155003599 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 936155003600 putative active site; other site 936155003601 catalytic triad [active] 936155003602 putative dimer interface [polypeptide binding]; other site 936155003603 HMMPfam hit to PF00795, CN_hydrolase, score 2.4e-46 936155003604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 936155003605 HMMPfam hit to PF01973, DUF115, score 1.2e-30 936155003606 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003607 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 936155003608 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 936155003609 active site 936155003610 substrate binding site [chemical binding]; other site 936155003611 metal binding site [ion binding]; metal-binding site 936155003612 HMMPfam hit to PF00408, PGM_PMM_IV, score 1.7e-09 936155003613 HMMPfam hit to PF02880, PGM_PMM_III, score 1.2e-18 936155003614 HMMPfam hit to PF02879, PGM_PMM_II, score 2.2e-26 936155003615 HMMPfam hit to PF02878, PGM_PMM_I, score 7.2e-28 936155003616 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature 936155003617 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site 936155003618 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 936155003619 HMMPfam hit to PF06002, CST-I, score 2.3e-07 936155003620 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 936155003621 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 936155003622 1 probable transmembrane helix predicted for Hfelis08350 by TMHMM2.0 at aa 7-24 936155003623 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 936155003624 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936155003625 12 probable transmembrane helices predicted for Hfelis08360 by TMHMM2.0 at aa 10-29, 42-64, 79-98, 111-133, 168-190, 202-224, 239-261, 268-290, 323-345, 371-393, 408-430 and 443-465 936155003626 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003627 HMMPfam hit to PF00361, Oxidored_q1, score 7.3e-39 936155003628 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003629 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 936155003630 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936155003631 14 probable transmembrane helices predicted for Hfelis08370 by TMHMM2.0 at aa 10-29, 36-55, 85-107, 114-136, 140-162, 169-191, 211-233, 246-268, 278-300, 307-324, 334-356, 376-398, 413-432 and 452-471 936155003632 HMMPfam hit to PF00361, Oxidored_q1, score 2.3e-74 936155003633 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003634 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 936155003635 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 936155003636 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936155003637 18 probable transmembrane helices predicted for Hfelis08380 by TMHMM2.0 at aa 7-29, 39-61, 68-85, 89-111, 118-137, 141-163, 184-206, 216-238, 251-270, 280-302, 309-331, 335-357, 377-399, 414-436, 457-479, 494-516, 539-561 and 595-617 936155003638 HMMPfam hit to PF00361, Oxidored_q1, score 3.7e-97 936155003639 HMMPfam hit to PF00662, Oxidored_q1_N, score 2.3e-23 936155003640 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 936155003641 HMMPfam hit to PF00420, Oxidored_q2, score 3.3e-31 936155003642 3 probable transmembrane helices predicted for Hfelis08390 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 936155003643 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 936155003644 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 936155003645 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 936155003646 5 probable transmembrane helices predicted for Hfelis08400 by TMHMM2.0 at aa 5-22, 27-46, 56-78, 91-113 and 144-166 936155003647 HMMPfam hit to PF00499, Oxidored_q3, score 2.5e-25 936155003648 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 936155003649 4Fe-4S binding domain; Region: Fer4; cl02805 936155003650 4Fe-4S binding domain; Region: Fer4; pfam00037 936155003651 HMMPfam hit to PF00037, Fer4, score 9.7e-10 936155003652 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155003653 HMMPfam hit to PF00037, Fer4, score 0.00011 936155003654 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 936155003655 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 936155003656 9 probable transmembrane helices predicted for Hfelis08420 by TMHMM2.0 at aa 12-29, 44-63, 75-97, 117-139, 152-174, 189-211, 243-265, 269-291 and 311-329 936155003657 HMMPfam hit to PF00146, NADHdh, score 5.5e-109 936155003658 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1 936155003659 NADH dehydrogenase subunit G; Validated; Region: PRK08493 936155003660 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936155003661 catalytic loop [active] 936155003662 iron binding site [ion binding]; other site 936155003663 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 936155003664 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936155003665 HMMPfam hit to PF00037, Fer4, score 0.00039 936155003666 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155003667 HMMPfam hit to PF10588, NADH-G_4Fe-4S_3, score 4.3e-17 936155003668 HMMPfam hit to PF00111, Fer2, score 2.1e-13 936155003669 NADH dehydrogenase subunit D; Validated; Region: PRK06075 936155003670 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 936155003671 HMMPfam hit to PF00346, Complex1_49kDa, score 2.8e-103 936155003672 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 936155003673 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 936155003674 HMMPfam hit to PF00329, Complex1_30kDa, score 6.4e-33 936155003675 PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature 936155003676 NADH dehydrogenase subunit B; Validated; Region: PRK06411 936155003677 HMMPfam hit to PF01058, Oxidored_q6, score 2e-60 936155003678 NADH dehydrogenase subunit A; Validated; Region: PRK08489 936155003679 HMMPfam hit to PF00507, Oxidored_q4, score 6.1e-27 936155003680 3 probable transmembrane helices predicted for Hfelis08480 by TMHMM2.0 at aa 10-29, 69-91 and 96-118 936155003681 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 936155003682 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155003683 HMMPfam hit to PF01856, HP_OMP, score 3.1e-47 936155003684 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 936155003685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155003686 dimer interface [polypeptide binding]; other site 936155003687 conserved gate region; other site 936155003688 putative PBP binding loops; other site 936155003689 ABC-ATPase subunit interface; other site 936155003690 6 probable transmembrane helices predicted for Hfelis08540 by TMHMM2.0 at aa 20-39, 141-163, 176-198, 202-224, 245-267 and 306-328 936155003691 HMMPfam hit to PF00528, BPD_transp_1, score 2.3e-35 936155003692 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 936155003693 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 936155003694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936155003695 Walker A/P-loop; other site 936155003696 ATP binding site [chemical binding]; other site 936155003697 Q-loop/lid; other site 936155003698 ABC transporter signature motif; other site 936155003699 Walker B; other site 936155003700 D-loop; other site 936155003701 H-loop/switch region; other site 936155003702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936155003703 Walker A/P-loop; other site 936155003704 ATP binding site [chemical binding]; other site 936155003705 Q-loop/lid; other site 936155003706 ABC transporter signature motif; other site 936155003707 Walker B; other site 936155003708 D-loop; other site 936155003709 H-loop/switch region; other site 936155003710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936155003711 HMMPfam hit to PF00005, ABC_tran, score 1.2e-58 936155003712 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003713 HMMPfam hit to PF00005, ABC_tran, score 6.9e-49 936155003714 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003715 PS00211 ABC transporters family signature 936155003716 HMMPfam hit to PF08352, oligo_HPY, score 1e-09 936155003717 TRL-like protein family; Region: TRL; pfam13146 936155003718 1 probable transmembrane helix predicted for Hfelis08560 by TMHMM2.0 at aa 7-29 936155003719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003720 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 936155003721 11 probable transmembrane helices predicted for Hfelis08570 by TMHMM2.0 at aa 4-21, 28-50, 70-92, 113-135, 199-218, 245-267, 282-304, 324-341, 356-378, 391-413 and 467-489 936155003722 HMMPfam hit to PF03553, Na_H_antiporter, score 1.3e-51 936155003723 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003724 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003725 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155003726 HMMPfam hit to PF02521, HP_OMP_2, score 1.7e-160 936155003727 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 936155003728 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 936155003729 putative NAD(P) binding site [chemical binding]; other site 936155003730 putative substrate binding site [chemical binding]; other site 936155003731 catalytic Zn binding site [ion binding]; other site 936155003732 structural Zn binding site [ion binding]; other site 936155003733 dimer interface [polypeptide binding]; other site 936155003734 HMMPfam hit to PF00107, ADH_zinc_N, score 6.8e-28 936155003735 HMMPfam hit to PF08240, ADH_N, score 1.9e-27 936155003736 PS00059 Zinc-containing alcohol dehydrogenases signature 936155003737 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936155003738 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936155003739 Cysteine-rich domain; Region: CCG; pfam02754 936155003740 Cysteine-rich domain; Region: CCG; pfam02754 936155003741 HMMPfam hit to PF02754, CCG, score 7.4e-09 936155003742 HMMPfam hit to PF02754, CCG, score 4.9e-10 936155003743 HMMPfam hit to PF00037, Fer4, score 0.00089 936155003744 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155003745 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 936155003746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155003747 FeS/SAM binding site; other site 936155003748 HemN C-terminal domain; Region: HemN_C; pfam06969 936155003749 HMMPfam hit to PF06969, HemN_C, score 3e-42 936155003750 HMMPfam hit to PF04055, Radical_SAM, score 1.4e-24 936155003751 PS00304 Small, acid-soluble spore proteins, alpha/beta type, signature 1 936155003752 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 936155003753 HMMPfam hit to PF10788, DUF2603, score 1.3e-27 936155003754 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 936155003755 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 936155003756 Tetramer interface [polypeptide binding]; other site 936155003757 active site 936155003758 FMN-binding site [chemical binding]; other site 936155003759 HMMPfam hit to PF01264, Chorismate_synt, score 1.2e-145 936155003760 PS00787 Chorismate synthase signature 1 936155003761 ribonuclease III; Reviewed; Region: rnc; PRK00102 936155003762 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 936155003763 dimerization interface [polypeptide binding]; other site 936155003764 active site 936155003765 metal binding site [ion binding]; metal-binding site 936155003766 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 936155003767 dsRNA binding site [nucleotide binding]; other site 936155003768 HMMPfam hit to PF00035, dsrm, score 3e-17 936155003769 HMMPfam hit to PF00636, Ribonuclease_3, score 5.4e-45 936155003770 PS00517 Ribonuclease III family signature 936155003771 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 936155003772 RNA/DNA hybrid binding site [nucleotide binding]; other site 936155003773 active site 936155003774 HMMPfam hit to PF00075, RnaseH, score 2.7e-45 936155003775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155003776 binding surface 936155003777 TPR motif; other site 936155003778 HMMPfam hit to PF07719, TPR_2, score 0.00033 936155003779 1 probable transmembrane helix predicted for Hfelis08660 by TMHMM2.0 at aa 12-31 936155003780 SurA N-terminal domain; Region: SurA_N; pfam09312 936155003781 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 936155003782 HMMPfam hit to PF09312, SurA_N, score 3.2e-07 936155003783 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155003784 Sel1-like repeats; Region: SEL1; smart00671 936155003785 Sel1-like repeats; Region: SEL1; smart00671 936155003786 Sel1-like repeats; Region: SEL1; smart00671 936155003787 Sel1-like repeats; Region: SEL1; smart00671 936155003788 Sel1-like repeats; Region: SEL1; smart00671 936155003789 HMMPfam hit to PF08238, Sel1, score 0.00012 936155003790 HMMPfam hit to PF08238, Sel1, score 4.9e-12 936155003791 HMMPfam hit to PF08238, Sel1, score 1.7e-11 936155003792 HMMPfam hit to PF08238, Sel1, score 3.9e-13 936155003793 HMMPfam hit to PF08238, Sel1, score 1.3e-08 936155003794 HMMPfam hit to PF08238, Sel1, score 8.4e-12 936155003795 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 936155003796 Glutamine amidotransferase class-I; Region: GATase; pfam00117 936155003797 glutamine binding [chemical binding]; other site 936155003798 catalytic triad [active] 936155003799 HMMPfam hit to PF00117, GATase, score 5.7e-57 936155003800 PS00442 Glutamine amidotransferases class-I active site 936155003801 anthranilate synthase component I; Provisional; Region: PRK13564 936155003802 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 936155003803 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936155003804 HMMPfam hit to PF00425, Chorismate_bind, score 1.3e-139 936155003805 HMMPfam hit to PF04715, Anth_synt_I_N, score 3.3e-15 936155003806 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 936155003807 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 936155003808 G1 box; other site 936155003809 GTP/Mg2+ binding site [chemical binding]; other site 936155003810 Switch I region; other site 936155003811 G2 box; other site 936155003812 G3 box; other site 936155003813 Switch II region; other site 936155003814 G4 box; other site 936155003815 G5 box; other site 936155003816 Nucleoside recognition; Region: Gate; pfam07670 936155003817 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 936155003818 Nucleoside recognition; Region: Gate; pfam07670 936155003819 HMMPfam hit to PF01926, MMR_HSR1, score 2e-34 936155003820 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003821 HMMPfam hit to PF02421, FeoB_N, score 6.3e-30 936155003822 8 probable transmembrane helices predicted for Hfelis08710 by TMHMM2.0 at aa 213-235, 269-291, 347-369, 379-396, 442-459, 529-551, 571-593 and 603-625 936155003823 HMMPfam hit to PF07670, Gate, score 8.1e-18 936155003824 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003825 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003826 HMMPfam hit to PF07664, FeoB_C, score 6.1e-22 936155003827 HMMPfam hit to PF07670, Gate, score 2.3e-17 936155003828 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 936155003829 Ferritin-like domain; Region: Ferritin; pfam00210 936155003830 ferroxidase diiron center [ion binding]; other site 936155003831 HMMPfam hit to PF00210, Ferritin, score 1.5e-41 936155003832 formamidase; Provisional; Region: amiF; PRK13287 936155003833 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 936155003834 multimer interface [polypeptide binding]; other site 936155003835 active site 936155003836 catalytic triad [active] 936155003837 dimer interface [polypeptide binding]; other site 936155003838 HMMPfam hit to PF00795, CN_hydrolase, score 4.5e-28 936155003839 1 probable transmembrane helix predicted for Hfelis08740 by TMHMM2.0 at aa 5-27 936155003840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003841 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155003842 dimer interface [polypeptide binding]; other site 936155003843 putative CheW interface [polypeptide binding]; other site 936155003844 HMMPfam hit to PF00015, MCPsignal, score 2.4e-35 936155003845 2 probable transmembrane helices predicted for Hfelis08750 by TMHMM2.0 at aa 10-32 and 314-336 936155003846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155003847 dimer interface [polypeptide binding]; other site 936155003848 putative CheW interface [polypeptide binding]; other site 936155003849 HMMPfam hit to PF00015, MCPsignal, score 1.1e-35 936155003850 3 probable transmembrane helices predicted for Hfelis08760 by TMHMM2.0 at aa 12-34, 172-194 and 315-337 936155003851 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155003852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155003853 dimer interface [polypeptide binding]; other site 936155003854 putative CheW interface [polypeptide binding]; other site 936155003855 HMMPfam hit to PF00015, MCPsignal, score 5.4e-34 936155003856 3 probable transmembrane helices predicted for Hfelis08770 by TMHMM2.0 at aa 7-29, 60-82 and 313-335 936155003857 PS00430 TonB-dependent receptor proteins signature 1 936155003858 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936155003859 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936155003860 HMMPfam hit to PF00924, MS_channel, score 2.8e-78 936155003861 PS01246 Uncharacterized protein family UPF0003 signature 936155003862 5 probable transmembrane helices predicted for Hfelis08780 by TMHMM2.0 at aa 248-270, 291-313, 328-350, 363-382 and 387-409 936155003863 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 936155003864 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936155003865 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936155003866 HMMPfam hit to PF02875, Mur_ligase_C, score 5.7e-12 936155003867 HMMPfam hit to PF08245, Mur_ligase_M, score 1.8e-18 936155003868 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 936155003869 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 936155003870 Mg++ binding site [ion binding]; other site 936155003871 putative catalytic motif [active] 936155003872 putative substrate binding site [chemical binding]; other site 936155003873 10 probable transmembrane helices predicted for Hfelis08800 by TMHMM2.0 at aa 13-35, 67-84, 89-106, 127-145, 167-186, 193-212, 227-249, 256-278, 282-304 and 331-350 936155003874 HMMPfam hit to PF00953, Glycos_transf_4, score 2.9e-55 936155003875 HMMPfam hit to PF10555, MraY_sig1, score 0.0018 936155003876 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 936155003877 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 936155003878 HMMPfam hit to PF03544, TonB, score 6.6e-13 936155003879 1 probable transmembrane helix predicted for Hfelis08810 by TMHMM2.0 at aa 13-35 936155003880 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 936155003881 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 936155003882 HMMPfam hit to PF02472, ExbD, score 1.9e-29 936155003883 1 probable transmembrane helix predicted for Hfelis08820 by TMHMM2.0 at aa 13-35 936155003884 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 936155003885 HMMPfam hit to PF01618, MotA_ExbB, score 4.3e-44 936155003886 3 probable transmembrane helices predicted for Hfelis08830 by TMHMM2.0 at aa 10-32, 67-89 and 109-131 936155003887 HMMPfam hit to PF01856, HP_OMP, score 6.9e-05 936155003888 2 probable transmembrane helices predicted for Hfelis08840 by TMHMM2.0 at aa 235-257 and 272-291 936155003889 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 936155003890 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936155003891 FMN binding site [chemical binding]; other site 936155003892 active site 936155003893 catalytic residues [active] 936155003894 substrate binding site [chemical binding]; other site 936155003895 HMMPfam hit to PF01207, Dus, score 5.5e-76 936155003896 PS00435 Peroxidases proximal heme-ligand signature 936155003897 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 936155003898 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 936155003899 active site 936155003900 NTP binding site [chemical binding]; other site 936155003901 metal binding triad [ion binding]; metal-binding site 936155003902 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 936155003903 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 936155003904 HMMPfam hit to PF01743, PolyA_pol, score 3e-50 936155003905 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 936155003906 Ligand Binding Site [chemical binding]; other site 936155003907 HMMPfam hit to PF06508, ExsB, score 3.9e-64 936155003908 chaperone protein DnaJ; Provisional; Region: PRK14299 936155003909 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936155003910 HSP70 interaction site [polypeptide binding]; other site 936155003911 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 936155003912 substrate binding site [polypeptide binding]; other site 936155003913 dimer interface [polypeptide binding]; other site 936155003914 HMMPfam hit to PF00226, DnaJ, score 6.1e-37 936155003915 PS00636 Nt-dnaJ domain signature 936155003916 HMMPfam hit to PF01556, DnaJ_C, score 2.2e-21 936155003917 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 936155003918 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 936155003919 DNA binding residues [nucleotide binding] 936155003920 Predicted helix-turn-helix motif with score 1755.000, SD 5.16 at aa 9-30, sequence YLISVVAKILGVHPQTLRQYEK 936155003921 HMMPfam hit to PF00376, MerR, score 1.3e-10 936155003922 PS00552 Bacterial regulatory proteins, merR family signature 936155003923 1 probable transmembrane helix predicted for Hfelis08900 by TMHMM2.0 at aa 5-27 936155003924 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 936155003926 HMMPfam hit to PF03734, YkuD, score 7.5e-09 936155003927 1 probable transmembrane helix predicted for Hfelis08910 by TMHMM2.0 at aa 5-27 936155003928 GTPase Era; Reviewed; Region: era; PRK00089 936155003929 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 936155003930 G1 box; other site 936155003931 GTP/Mg2+ binding site [chemical binding]; other site 936155003932 Switch I region; other site 936155003933 G2 box; other site 936155003934 Switch II region; other site 936155003935 G3 box; other site 936155003936 G4 box; other site 936155003937 G5 box; other site 936155003938 KH domain; Region: KH_2; pfam07650 936155003939 HMMPfam hit to PF07650, KH_2, score 1.5e-20 936155003940 HMMPfam hit to PF01926, MMR_HSR1, score 1.5e-32 936155003941 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003942 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 936155003943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155003944 Walker A motif; other site 936155003945 ATP binding site [chemical binding]; other site 936155003946 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 936155003947 Walker B motif; other site 936155003948 arginine finger; other site 936155003949 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936155003950 HMMPfam hit to PF07724, AAA_2, score 1.9e-43 936155003951 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003952 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 936155003953 active site 936155003954 HslU subunit interaction site [polypeptide binding]; other site 936155003955 HMMPfam hit to PF00227, Proteasome, score 1.7e-21 936155003956 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 936155003957 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 936155003958 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 936155003959 HMMPfam hit to PF03948, Ribosomal_L9_C, score 1.2e-22 936155003960 HMMPfam hit to PF01281, Ribosomal_L9_N, score 2.8e-24 936155003961 PS00651 Ribosomal protein L9 signature 936155003962 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 936155003963 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 936155003964 Methyltransferase domain; Region: Methyltransf_26; pfam13659 936155003965 HMMPfam hit to PF02384, N6_Mtase, score 1.3e-20 936155003966 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003967 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936155003968 active site 936155003969 HMMPfam hit to PF00849, PseudoU_synth_2, score 2.5e-25 936155003970 PS01129 Rlu family of pseudouridine synthase signature 936155003971 CTP synthetase; Validated; Region: pyrG; PRK05380 936155003972 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 936155003973 Catalytic site [active] 936155003974 active site 936155003975 UTP binding site [chemical binding]; other site 936155003976 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 936155003977 active site 936155003978 putative oxyanion hole; other site 936155003979 catalytic triad [active] 936155003980 HMMPfam hit to PF00117, GATase, score 2.3e-54 936155003981 PS00442 Glutamine amidotransferases class-I active site 936155003982 HMMPfam hit to PF06418, CTP_synth_N, score 3.3e-178 936155003983 AMIN domain; Region: AMIN; pfam11741 936155003984 1 probable transmembrane helix predicted for Hfelis09000 by TMHMM2.0 at aa 15-34 936155003985 recombinase A; Provisional; Region: recA; PRK09354 936155003986 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 936155003987 hexamer interface [polypeptide binding]; other site 936155003988 Walker A motif; other site 936155003989 ATP binding site [chemical binding]; other site 936155003990 Walker B motif; other site 936155003991 HMMPfam hit to PF00154, RecA, score 2.9e-245 936155003992 PS00321 recA signature 936155003993 PS00017 ATP/GTP-binding site motif A (P-loop) 936155003994 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155003995 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 936155003996 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 936155003997 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 936155003998 active site 936155003999 dimer interface [polypeptide binding]; other site 936155004000 motif 1; other site 936155004001 motif 2; other site 936155004002 motif 3; other site 936155004003 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 936155004004 anticodon binding site; other site 936155004005 HMMPfam hit to PF07973, tRNA_SAD, score 7.2e-23 936155004006 HMMPfam hit to PF00587, tRNA-synt_2b, score 7.8e-55 936155004007 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155004008 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155004009 HMMPfam hit to PF03129, HGTP_anticodon, score 9.3e-29 936155004010 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 936155004011 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 936155004012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 936155004013 HMMPfam hit to PF05198, IF3_N, score 1.3e-40 936155004014 PS00938 Initiation factor 3 signature 936155004015 HMMPfam hit to PF00707, IF3_C, score 2.9e-41 936155004016 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 936155004017 HMMPfam hit to PF01632, Ribosomal_L35p, score 1.2e-26 936155004018 PS00936 Ribosomal protein L35 signature 936155004019 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 936155004020 23S rRNA binding site [nucleotide binding]; other site 936155004021 L21 binding site [polypeptide binding]; other site 936155004022 L13 binding site [polypeptide binding]; other site 936155004023 HMMPfam hit to PF00453, Ribosomal_L20, score 1.5e-49 936155004024 PS00937 Ribosomal protein L20 signature 936155004025 polyphosphate kinase; Provisional; Region: PRK05443 936155004026 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 936155004027 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 936155004028 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 936155004029 putative domain interface [polypeptide binding]; other site 936155004030 putative active site [active] 936155004031 catalytic site [active] 936155004032 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 936155004033 putative domain interface [polypeptide binding]; other site 936155004034 putative active site [active] 936155004035 catalytic site [active] 936155004036 HMMPfam hit to PF02503, PP_kinase, score 0 936155004037 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 936155004038 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 936155004039 quinone interaction residues [chemical binding]; other site 936155004040 active site 936155004041 catalytic residues [active] 936155004042 FMN binding site [chemical binding]; other site 936155004043 substrate binding site [chemical binding]; other site 936155004044 HMMPfam hit to PF01180, DHO_dh, score 1.5e-66 936155004045 PS00911 Dihydroorotate dehydrogenase signature 1 936155004046 PS00912 Dihydroorotate dehydrogenase signature 2 936155004047 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936155004048 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936155004049 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936155004050 HMMPfam hit to PF00675, Peptidase_M16, score 1.1e-19 936155004051 PS00143 Insulinase family, zinc-binding region signature 936155004052 HMMPfam hit to PF05193, Peptidase_M16_C, score 5.4e-33 936155004053 dihydrodipicolinate synthase; Region: dapA; TIGR00674 936155004054 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 936155004055 dimer interface [polypeptide binding]; other site 936155004056 active site 936155004057 catalytic residue [active] 936155004058 HMMPfam hit to PF00701, DHDPS, score 8e-89 936155004059 PS00666 Dihydrodipicolinate synthetase signature 2 936155004060 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 936155004061 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 936155004062 putative NAD(P) binding site [chemical binding]; other site 936155004063 active site 936155004064 HMMPfam hit to PF00106, adh_short, score 4e-07 936155004065 6 probable transmembrane helices predicted for Hfelis09120 by TMHMM2.0 at aa 19-41, 46-68, 80-102, 106-128, 141-163 and 173-195 936155004066 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 936155004067 2 probable transmembrane helices predicted for Hfelis09130 by TMHMM2.0 at aa 13-35 and 154-176 936155004068 HMMPfam hit to PF01066, CDP-OH_P_transf, score 2.5e-31 936155004069 PS00379 CDP-alcohol phosphatidyltransferases signature 936155004070 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 936155004071 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 936155004072 active site 936155004073 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 936155004074 protein binding site [polypeptide binding]; other site 936155004075 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 936155004076 putative substrate binding region [chemical binding]; other site 936155004077 4 probable transmembrane helices predicted for Hfelis09140 by TMHMM2.0 at aa 2-24, 86-108, 266-288 and 314-331 936155004078 HMMPfam hit to PF02163, Peptidase_M50, score 3.8e-52 936155004079 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature 936155004080 HMMPfam hit to PF00595, PDZ, score 1.7e-08 936155004081 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004082 HMMPfam hit to PF01856, HP_OMP, score 4.9e-05 936155004083 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004084 HMMPfam hit to PF01856, HP_OMP, score 5.8e-49 936155004085 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 936155004086 active site pocket [active] 936155004087 oxyanion hole [active] 936155004088 catalytic triad [active] 936155004089 active site nucleophile [active] 936155004090 HMMPfam hit to PF03575, Peptidase_S51, score 4.2e-50 936155004091 PS00120 Lipases, serine active site 936155004092 phosphoenolpyruvate synthase; Validated; Region: PRK06464 936155004093 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 936155004094 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936155004095 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 936155004096 HMMPfam hit to PF02896, PEP-utilizers_C, score 1.7e-62 936155004097 PS00742 PEP-utilizing enzymes signature 2 936155004098 HMMPfam hit to PF00391, PEP-utilizers, score 6e-35 936155004099 PS00370 PEP-utilizing enzymes phosphorylation site signature 936155004100 HMMPfam hit to PF01326, PPDK_N, score 2.5e-162 936155004101 aminodeoxychorismate synthase; Provisional; Region: PRK07508 936155004102 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936155004103 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 936155004104 substrate-cofactor binding pocket; other site 936155004105 homodimer interface [polypeptide binding]; other site 936155004106 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 936155004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155004108 catalytic residue [active] 936155004109 HMMPfam hit to PF01063, Aminotran_4, score 7.2e-06 936155004110 HMMPfam hit to PF00425, Chorismate_bind, score 1.6e-27 936155004111 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 936155004112 HMMPfam hit to PF09924, DUF2156, score 5.2e-121 936155004113 diaminopimelate decarboxylase; Region: lysA; TIGR01048 936155004114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 936155004115 active site 936155004116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936155004117 substrate binding site [chemical binding]; other site 936155004118 catalytic residues [active] 936155004119 dimer interface [polypeptide binding]; other site 936155004120 Chorismate mutase type II; Region: CM_2; smart00830 936155004121 HMMPfam hit to PF01817, CM_2, score 1.1e-12 936155004122 HMMPfam hit to PF00278, Orn_DAP_Arg_deC, score 1.8e-34 936155004123 HMMPfam hit to PF02784, Orn_Arg_deC_N, score 9e-65 936155004124 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2 936155004125 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site 936155004126 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 936155004127 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 936155004128 HMMPfam hit to PF01558, POR, score 1.2e-40 936155004129 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 936155004130 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 936155004131 TPP-binding site [chemical binding]; other site 936155004132 HMMPfam hit to PF02775, TPP_enzyme_C, score 1.6e-51 936155004133 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 936155004134 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 936155004135 dimer interface [polypeptide binding]; other site 936155004136 PYR/PP interface [polypeptide binding]; other site 936155004137 TPP binding site [chemical binding]; other site 936155004138 substrate binding site [chemical binding]; other site 936155004139 HMMPfam hit to PF01855, POR_N, score 5.1e-98 936155004140 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 936155004141 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 936155004142 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155004143 HMMPfam hit to PF00037, Fer4, score 1.1e-07 936155004144 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155004145 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 936155004146 HMMPfam hit to PF03743, TrbI, score 8.9e-75 936155004147 1 probable transmembrane helix predicted for Hfelis09260 by TMHMM2.0 at aa 9-26 936155004148 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 936155004149 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 936155004150 VirB7 interaction site; other site 936155004151 HMMPfam hit to PF03524, CagX, score 1.9e-05 936155004152 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 936155004153 putative metal binding site [ion binding]; other site 936155004154 1 probable transmembrane helix predicted for Hfelis09280 by TMHMM2.0 at aa 3-20 936155004155 2 probable transmembrane helices predicted for Hfelis09290 by TMHMM2.0 at aa 12-34 and 39-61 936155004156 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 936155004157 Cysteine-rich domain; Region: CCG; pfam02754 936155004158 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 936155004159 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 936155004160 active site 936155004161 Zn binding site [ion binding]; other site 936155004162 HMMPfam hit to PF01432, Peptidase_M3, score 2.6e-92 936155004163 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature 936155004164 HMMPfam hit to PF08439, Peptidase_M3_N, score 2.4e-11 936155004165 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 936155004166 11 probable transmembrane helices predicted for Hfelis09330 by TMHMM2.0 at aa 4-23, 30-47, 57-74, 85-107, 111-133, 146-168, 173-195, 216-238, 291-313, 326-343 and 374-396 936155004167 HMMPfam hit to PF00999, Na_H_Exchanger, score 2.4e-63 936155004168 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 936155004169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936155004170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155004171 active site 936155004172 phosphorylation site [posttranslational modification] 936155004173 intermolecular recognition site; other site 936155004174 dimerization interface [polypeptide binding]; other site 936155004175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936155004176 DNA binding site [nucleotide binding] 936155004177 HMMPfam hit to PF00072, Response_reg, score 1.3e-28 936155004178 HMMPfam hit to PF00486, Trans_reg_C, score 1.7e-19 936155004179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936155004180 HAMP domain; Region: HAMP; pfam00672 936155004181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936155004182 dimer interface [polypeptide binding]; other site 936155004183 phosphorylation site [posttranslational modification] 936155004184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155004185 ATP binding site [chemical binding]; other site 936155004186 Mg2+ binding site [ion binding]; other site 936155004187 G-X-G motif; other site 936155004188 2 probable transmembrane helices predicted for Hfelis09370 by TMHMM2.0 at aa 7-26 and 130-152 936155004189 PS00225 Crystallins beta and gamma 'Greek key' motif signature 936155004190 HMMPfam hit to PF00672, HAMP, score 7.8e-06 936155004191 HMMPfam hit to PF00512, HisKA, score 2.5e-05 936155004192 HMMPfam hit to PF02518, HATPase_c, score 2.9e-10 936155004193 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 936155004194 dimer interface [polypeptide binding]; other site 936155004195 active site 936155004196 Schiff base residues; other site 936155004197 HMMPfam hit to PF00490, ALAD, score 6.6e-170 936155004198 PS00169 Delta-aminolevulinic acid dehydratase active site 936155004199 hypothetical protein; Provisional; Region: PRK12378 936155004200 HMMPfam hit to PF01709, DUF28, score 9.9e-88 936155004201 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 936155004202 Citrate synthase; Region: Citrate_synt; pfam00285 936155004203 oxalacetate binding site [chemical binding]; other site 936155004204 citrylCoA binding site [chemical binding]; other site 936155004205 coenzyme A binding site [chemical binding]; other site 936155004206 catalytic triad [active] 936155004207 HMMPfam hit to PF00285, Citrate_synt, score 1.3e-104 936155004208 PS00480 Citrate synthase signature 936155004209 11 probable transmembrane helices predicted for Hfelis09410 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 108-130, 160-182, 192-208, 629-651, 661-680, 769-791, 796-818 and 831-848 936155004210 PS00044 Bacterial regulatory proteins, lysR family signature 936155004211 PS01125 ROK family signature 936155004212 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 936155004213 active site 936155004214 dimerization interface [polypeptide binding]; other site 936155004215 HMMPfam hit to PF01725, Ham1p_like, score 8.2e-41 936155004216 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936155004217 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936155004218 catalytic residues [active] 936155004219 HMMPfam hit to PF00085, Thioredoxin, score 1.6e-17 936155004220 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 936155004221 LytB protein; Region: LYTB; pfam02401 936155004222 HMMPfam hit to PF02401, LYTB, score 5.7e-134 936155004223 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 936155004224 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 936155004225 hinge; other site 936155004226 active site 936155004227 HMMPfam hit to PF00275, EPSP_synthase, score 1.4e-103 936155004228 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004229 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 936155004230 putative tRNA-binding site [nucleotide binding]; other site 936155004231 tRNA synthetase B5 domain; Region: B5; smart00874 936155004232 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 936155004233 dimer interface [polypeptide binding]; other site 936155004234 motif 1; other site 936155004235 motif 3; other site 936155004236 motif 2; other site 936155004237 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 936155004238 HMMPfam hit to PF03147, FDX-ACB, score 2.2e-18 936155004239 HMMPfam hit to PF03484, B5, score 3.1e-18 936155004240 HMMPfam hit to PF01588, tRNA_bind, score 5.6e-24 936155004241 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 936155004242 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 936155004243 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 936155004244 dimer interface [polypeptide binding]; other site 936155004245 motif 1; other site 936155004246 active site 936155004247 motif 2; other site 936155004248 motif 3; other site 936155004249 HMMPfam hit to PF01409, tRNA-synt_2d, score 2e-140 936155004250 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155004251 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155004252 HMMPfam hit to PF02912, Phe_tRNA-synt_N, score 1.6e-17 936155004253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004254 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 936155004255 DHH family; Region: DHH; pfam01368 936155004256 HMMPfam hit to PF02272, DHHA1, score 7.4e-07 936155004257 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 936155004258 FHIPEP family; Region: FHIPEP; pfam00771 936155004259 HMMPfam hit to PF00771, FHIPEP, score 0 936155004260 7 probable transmembrane helices predicted for Hfelis09500 by TMHMM2.0 at aa 20-42, 46-68, 75-97, 127-149, 214-233, 243-265 and 298-332 936155004261 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 936155004262 16S/18S rRNA binding site [nucleotide binding]; other site 936155004263 S13e-L30e interaction site [polypeptide binding]; other site 936155004264 25S rRNA binding site [nucleotide binding]; other site 936155004265 HMMPfam hit to PF00312, Ribosomal_S15, score 3e-30 936155004266 PS00362 Ribosomal protein S15 signature 936155004267 O-Antigen ligase; Region: Wzy_C; pfam04932 936155004268 11 probable transmembrane helices predicted for Hfelis09520 by TMHMM2.0 at aa 23-42, 55-74, 89-108, 115-137, 147-169, 176-193, 197-214, 221-238, 336-358, 363-385 and 390-407 936155004269 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004270 HMMPfam hit to PF04932, Wzy_C, score 1.6e-06 936155004271 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 936155004272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155004273 ATP binding site [chemical binding]; other site 936155004274 Mg2+ binding site [ion binding]; other site 936155004275 G-X-G motif; other site 936155004276 HMMPfam hit to PF02518, HATPase_c, score 2.1e-22 936155004277 HMMPfam hit to PF00512, HisKA, score 9.8e-11 936155004278 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 936155004279 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 936155004280 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 936155004281 HMMPfam hit to PF02119, FlgI, score 3.9e-143 936155004282 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 936155004283 HMMPfam hit to PF01790, LGT, score 3.5e-91 936155004284 6 probable transmembrane helices predicted for Hfelis09560 by TMHMM2.0 at aa 20-42, 63-82, 105-127, 134-156, 212-234 and 247-269 936155004285 PS01311 Prolipoprotein diacylglyceryl transferase signature 936155004286 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 936155004287 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936155004288 active site 936155004289 HMMPfam hit to PF00849, PseudoU_synth_2, score 1.4e-23 936155004290 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 936155004291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004292 HMMPfam hit to PF04413, Glycos_transf_N, score 3.7e-44 936155004293 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 936155004294 Putative zinc ribbon domain; Region: DUF164; pfam02591 936155004295 HMMPfam hit to PF02591, DUF164, score 1.8e-24 936155004296 Uncharacterized conserved protein [Function unknown]; Region: COG0327 936155004297 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 936155004298 HMMPfam hit to PF01784, NIF3, score 8.3e-47 936155004299 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 936155004300 motif 1; other site 936155004301 dimer interface [polypeptide binding]; other site 936155004302 active site 936155004303 motif 2; other site 936155004304 motif 3; other site 936155004305 HMMPfam hit to PF02091, tRNA-synt_2e, score 4.8e-192 936155004306 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155004307 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 936155004308 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936155004309 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 936155004310 HMMPfam hit to PF07479, NAD_Gly3P_dh_C, score 1.5e-62 936155004311 HMMPfam hit to PF01210, NAD_Gly3P_dh_N, score 6.5e-31 936155004312 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 936155004313 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 936155004314 HMMPfam hit to PF00873, ACR_tran, score 0 936155004315 12 probable transmembrane helices predicted for Hfelis09640 by TMHMM2.0 at aa 13-32, 331-353, 360-379, 389-411, 432-454, 469-491, 525-547, 858-877, 882-904, 914-933, 959-981 and 991-1013 936155004316 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004317 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936155004318 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 936155004319 HlyD family secretion protein; Region: HlyD_3; pfam13437 936155004320 Outer membrane efflux protein; Region: OEP; pfam02321 936155004321 HMMPfam hit to PF02321, OEP, score 4.1e-13 936155004322 1 probable transmembrane helix predicted for Hfelis09660 by TMHMM2.0 at aa 9-31 936155004323 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 936155004324 HMMPfam hit to PF02092, tRNA_synt_2f, score 7.3e-172 936155004325 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004326 phosphoglyceromutase; Provisional; Region: PRK05434 936155004327 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 936155004328 HMMPfam hit to PF06415, iPGM_N, score 2.9e-171 936155004329 HMMPfam hit to PF01676, Metalloenzyme, score 4e-42 936155004330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936155004331 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 936155004332 putative active site [active] 936155004333 heme pocket [chemical binding]; other site 936155004334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936155004335 putative active site [active] 936155004336 heme pocket [chemical binding]; other site 936155004337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155004338 dimer interface [polypeptide binding]; other site 936155004339 putative CheW interface [polypeptide binding]; other site 936155004340 HMMPfam hit to PF08447, PAS_3, score 2e-13 936155004341 HMMPfam hit to PF08447, PAS_3, score 1.9e-14 936155004342 HMMPfam hit to PF00015, MCPsignal, score 6.2e-38 936155004343 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 936155004344 propionate/acetate kinase; Provisional; Region: PRK12379 936155004345 HMMPfam hit to PF00871, Acetate_kinase, score 3.1e-182 936155004346 PS01076 Acetate and butyrate kinases family signature 2 936155004347 PS01075 Acetate and butyrate kinases family signature 1 936155004348 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 936155004349 HMMPfam hit to PF01515, PTA_PTB, score 5.5e-176 936155004350 shikimate kinase; Reviewed; Region: aroK; PRK00131 936155004351 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 936155004352 ADP binding site [chemical binding]; other site 936155004353 magnesium binding site [ion binding]; other site 936155004354 putative shikimate binding site; other site 936155004355 HMMPfam hit to PF01202, SKI, score 4.4e-46 936155004356 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004357 enolase; Provisional; Region: eno; PRK00077 936155004358 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 936155004359 dimer interface [polypeptide binding]; other site 936155004360 metal binding site [ion binding]; metal-binding site 936155004361 substrate binding pocket [chemical binding]; other site 936155004362 HMMPfam hit to PF00113, Enolase_C, score 1e-134 936155004363 HMMPfam hit to PF03952, Enolase_N, score 2e-51 936155004364 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004365 HMMPfam hit to PF01856, HP_OMP, score 3.2e-08 936155004366 PS00589 PTS HPR component serine phosphorylation site signature 936155004367 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 936155004368 Permease; Region: Permease; cl00510 936155004369 5 probable transmembrane helices predicted for Hfelis09760 by TMHMM2.0 at aa 120-142, 163-185, 258-280, 301-323 and 338-360 936155004370 HMMPfam hit to PF02405, DUF140, score 9.6e-93 936155004371 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936155004373 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 936155004374 Walker A/P-loop; other site 936155004375 ATP binding site [chemical binding]; other site 936155004376 Q-loop/lid; other site 936155004377 ABC transporter signature motif; other site 936155004378 Walker B; other site 936155004379 D-loop; other site 936155004380 H-loop/switch region; other site 936155004381 HMMPfam hit to PF00005, ABC_tran, score 2.2e-58 936155004382 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004383 PS00211 ABC transporters family signature 936155004384 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 936155004385 mce related protein; Region: MCE; pfam02470 936155004386 1 probable transmembrane helix predicted for Hfelis09780 by TMHMM2.0 at aa 7-29 936155004387 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004388 HMMPfam hit to PF02470, MCE, score 4.4e-18 936155004389 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155004391 binding surface 936155004392 TPR motif; other site 936155004393 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155004394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155004395 binding surface 936155004396 TPR motif; other site 936155004397 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155004398 Sel1-like repeats; Region: SEL1; smart00671 936155004399 Sel1-like repeats; Region: SEL1; smart00671 936155004400 Sel1-like repeats; Region: SEL1; smart00671 936155004401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155004402 binding surface 936155004403 TPR motif; other site 936155004404 Sel1-like repeats; Region: SEL1; smart00671 936155004405 Sel1-like repeats; Region: SEL1; smart00671 936155004406 HMMPfam hit to PF08238, Sel1, score 3.2e-11 936155004407 HMMPfam hit to PF08238, Sel1, score 9.3e-09 936155004408 HMMPfam hit to PF08238, Sel1, score 2.6e-10 936155004409 HMMPfam hit to PF08238, Sel1, score 3.4e-09 936155004410 HMMPfam hit to PF08238, Sel1, score 2.5e-09 936155004411 HMMPfam hit to PF08238, Sel1, score 1e-09 936155004412 HMMPfam hit to PF08238, Sel1, score 3e-08 936155004413 HMMPfam hit to PF08238, Sel1, score 1.8e-10 936155004414 HMMPfam hit to PF08238, Sel1, score 7.3e-11 936155004415 HMMPfam hit to PF08238, Sel1, score 4.1e-10 936155004416 HMMPfam hit to PF08238, Sel1, score 1.7e-07 936155004417 HMMPfam hit to PF08238, Sel1, score 4.4e-07 936155004418 HMMPfam hit to PF08238, Sel1, score 1.7e-10 936155004419 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 936155004420 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 936155004421 putative active site [active] 936155004422 HMMPfam hit to PF01075, Glyco_transf_9, score 7.7e-57 936155004423 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 936155004424 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155004425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936155004426 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155004427 dimer interface [polypeptide binding]; other site 936155004428 putative CheW interface [polypeptide binding]; other site 936155004429 2 probable transmembrane helices predicted for Hfelis09820 by TMHMM2.0 at aa 10-29 and 174-196 936155004430 HMMPfam hit to PF00672, HAMP, score 4.6e-07 936155004431 HMMPfam hit to PF00015, MCPsignal, score 1.1e-32 936155004432 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 936155004433 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 936155004434 active site 936155004435 PHP Thumb interface [polypeptide binding]; other site 936155004436 metal binding site [ion binding]; metal-binding site 936155004437 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 936155004438 generic binding surface I; other site 936155004439 generic binding surface II; other site 936155004440 HMMPfam hit to PF02811, PHP, score 4.6e-68 936155004441 HMMPfam hit to PF07733, DNA_pol3_alpha, score 1.6e-279 936155004442 HMMPfam hit to PF01336, tRNA_anti, score 3.7e-05 936155004443 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 936155004444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155004445 RNA binding surface [nucleotide binding]; other site 936155004446 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 936155004447 active site 936155004448 HMMPfam hit to PF01479, S4, score 5.5e-07 936155004449 HMMPfam hit to PF00849, PseudoU_synth_2, score 2.1e-07 936155004450 PS01149 Rsu family of pseudouridine synthase signature 936155004451 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155004452 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155004453 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.3e-84 936155004454 PS00092 N-6 Adenine-specific DNA methylases signature 936155004455 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936155004456 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 936155004457 transmembrane helices; other site 936155004458 15 probable transmembrane helices predicted for Hfelis09860 by TMHMM2.0 at aa 7-29, 49-66, 71-88, 93-115, 128-150, 160-178, 224-246, 272-294, 315-337, 347-369, 389-411, 415-437, 444-463, 468-490 and 511-533 936155004459 HMMPfam hit to PF00939, Na_sulph_symp, score 3.9e-22 936155004460 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 936155004461 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 936155004462 HMMPfam hit to PF01148, CTP_transf_1, score 1.4e-44 936155004463 6 probable transmembrane helices predicted for Hfelis09870 by TMHMM2.0 at aa 13-30, 34-51, 58-80, 108-125, 132-154 and 187-209 936155004464 PS01315 Phosphatidate cytidylyltransferase signature 936155004465 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 936155004466 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 936155004467 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 936155004468 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 936155004469 HMMPfam hit to PF02670, DXP_reductoisom, score 2.7e-42 936155004470 HMMPfam hit to PF08436, DXP_redisom_C, score 5.5e-38 936155004471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 936155004472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936155004473 PAS fold; Region: PAS_3; pfam08447 936155004474 putative active site [active] 936155004475 heme pocket [chemical binding]; other site 936155004476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155004477 putative CheW interface [polypeptide binding]; other site 936155004478 PS00215 Mitochondrial energy transfer proteins signature 936155004479 HMMPfam hit to PF08447, PAS_3, score 1.5e-22 936155004480 HMMPfam hit to PF00015, MCPsignal, score 2e-31 936155004481 arginine decarboxylase; Provisional; Region: PRK05354 936155004482 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 936155004483 active site 936155004484 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936155004485 catalytic residues [active] 936155004486 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 936155004487 HMMPfam hit to PF02784, Orn_Arg_deC_N, score 7.5e-26 936155004488 HMMPfam hit to PF00278, Orn_DAP_Arg_deC, score 7.9e-31 936155004489 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 936155004490 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 936155004491 HMMPfam hit to PF02606, LpxK, score 2.4e-72 936155004492 PS00136 Serine proteases, subtilase family, aspartic acid active site 936155004493 NAD synthase; Region: NAD_synthase; pfam02540 936155004494 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 936155004495 NAD binding pocket [chemical binding]; other site 936155004496 ATP binding pocket [chemical binding]; other site 936155004497 Mg binding site [ion binding]; other site 936155004498 active-site loop [active] 936155004499 homodimer interface [polypeptide binding]; other site 936155004500 HMMPfam hit to PF02540, NAD_synthase, score 3.1e-79 936155004501 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004502 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 936155004503 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 936155004504 iron-sulfur cluster [ion binding]; other site 936155004505 [2Fe-2S] cluster binding site [ion binding]; other site 936155004506 1 probable transmembrane helix predicted for Hfelis09950 by TMHMM2.0 at aa 9-28 936155004507 HMMPfam hit to PF00355, Rieske, score 5e-11 936155004508 PS00199 Rieske iron-sulfur protein signature 1 936155004509 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 936155004510 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 936155004511 intrachain domain interface; other site 936155004512 interchain domain interface [polypeptide binding]; other site 936155004513 heme bH binding site [chemical binding]; other site 936155004514 Qi binding site; other site 936155004515 heme bL binding site [chemical binding]; other site 936155004516 Qo binding site; other site 936155004517 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 936155004518 interchain domain interface [polypeptide binding]; other site 936155004519 intrachain domain interface; other site 936155004520 Qi binding site; other site 936155004521 Qo binding site; other site 936155004522 HMMPfam hit to PF00033, Cytochrom_B_N, score 2.8e-67 936155004523 9 probable transmembrane helices predicted for Hfelis09960 by TMHMM2.0 at aa 39-61, 96-118, 125-147, 162-184, 191-213, 249-271, 314-336, 351-373 and 380-402 936155004524 HMMPfam hit to PF00032, Cytochrom_B_C, score 3.5e-07 936155004525 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 936155004526 Cytochrome c; Region: Cytochrom_C; pfam00034 936155004527 Cytochrome c; Region: Cytochrom_C; cl11414 936155004528 2 probable transmembrane helices predicted for Hfelis09970 by TMHMM2.0 at aa 7-29 and 257-276 936155004529 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 936155004530 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 936155004531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155004532 catalytic residue [active] 936155004533 HMMPfam hit to PF00291, PALP, score 2e-20 936155004534 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site 936155004535 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 936155004536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 936155004537 Uncharacterized conserved protein [Function unknown]; Region: COG1479 936155004538 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155004539 Uncharacterized conserved protein [Function unknown]; Region: COG3472 936155004540 HMMPfam hit to PF09854, DUF2081, score 9.1e-31 936155004541 HMMPfam hit to PF03235, DUF262, score 1.1e-32 936155004542 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 936155004543 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936155004544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936155004545 HMMPfam hit to PF06429, DUF1078, score 2.8e-13 936155004546 HMMPfam hit to PF07559, FlaE, score 9.9e-11 936155004547 HMMPfam hit to PF00460, Flg_bb_rod, score 1.2e-05 936155004548 PS00588 Flagella basal body rod proteins signature 936155004549 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 936155004550 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 936155004551 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 936155004552 HMMPfam hit to PF03963, FlgD, score 1.3e-33 936155004553 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 936155004554 RDD family; Region: RDD; pfam06271 936155004555 HMMPfam hit to PF06271, RDD, score 1e-16 936155004556 3 probable transmembrane helices predicted for Hfelis10060 by TMHMM2.0 at aa 20-42, 52-71 and 102-121 936155004557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155004558 active site 936155004559 HMMPfam hit to PF00156, Pribosyltran, score 2.6e-22 936155004560 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 936155004561 ribosome recycling factor; Reviewed; Region: frr; PRK00083 936155004562 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 936155004563 hinge region; other site 936155004564 HMMPfam hit to PF01765, RRF, score 1.6e-87 936155004565 Predicted helix-turn-helix motif with score 974.000, SD 2.50 at aa 152-173, sequence QGKKALAEVQKITDSAIKKIEE 936155004566 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 936155004567 HMMPfam hit to PF03840, SecG, score 1.1e-24 936155004568 2 probable transmembrane helices predicted for Hfelis10090 by TMHMM2.0 at aa 5-22 and 53-72 936155004569 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 936155004570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155004571 S-adenosylmethionine binding site [chemical binding]; other site 936155004572 HMMPfam hit to PF08241, Methyltransf_11, score 5.4e-08 936155004573 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 936155004574 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 936155004575 active site 936155004576 HIGH motif; other site 936155004577 dimer interface [polypeptide binding]; other site 936155004578 KMSKS motif; other site 936155004579 HMMPfam hit to PF00579, tRNA-synt_1b, score 1.4e-104 936155004580 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155004581 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004582 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 936155004583 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 936155004584 HMMPfam hit to PF00496, SBP_bac_5, score 5e-51 936155004585 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 936155004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155004587 dimer interface [polypeptide binding]; other site 936155004588 conserved gate region; other site 936155004589 putative PBP binding loops; other site 936155004590 ABC-ATPase subunit interface; other site 936155004591 6 probable transmembrane helices predicted for Hfelis10130 by TMHMM2.0 at aa 9-31, 127-149, 162-184, 215-237, 277-299 and 319-338 936155004592 HMMPfam hit to PF00528, BPD_transp_1, score 1.1e-49 936155004593 Bacterial SH3 domain; Region: SH3_3; pfam08239 936155004594 1 probable transmembrane helix predicted for Hfelis10140 by TMHMM2.0 at aa 7-29 936155004595 HMMPfam hit to PF08239, SH3_3, score 2.5e-05 936155004596 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 936155004597 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 936155004598 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 936155004599 shikimate binding site; other site 936155004600 NAD(P) binding site [chemical binding]; other site 936155004601 HMMPfam hit to PF08501, Shikimate_dh_N, score 7.1e-24 936155004602 HMMPfam hit to PF01488, Shikimate_DH, score 1.3e-15 936155004603 PS00959 Histone H3 signature 2 936155004604 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 936155004605 dimer interface [polypeptide binding]; other site 936155004606 active site 936155004607 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 936155004608 Sulfatase; Region: Sulfatase; cl17466 936155004609 HMMPfam hit to PF00884, Sulfatase, score 6.6e-38 936155004610 Sulfatase; Region: Sulfatase; cl17466 936155004611 HMMPfam hit to PF00884, Sulfatase, score 1.5e-09 936155004612 5 probable transmembrane helices predicted for Hfelis10180 by TMHMM2.0 at aa 7-29, 39-56, 63-85, 112-134 and 146-168 936155004613 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 936155004614 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 936155004615 putative ribose interaction site [chemical binding]; other site 936155004616 putative ADP binding site [chemical binding]; other site 936155004617 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 936155004618 active site 936155004619 HIGH motif; other site 936155004620 nucleotide binding site [chemical binding]; other site 936155004621 HMMPfam hit to PF01467, CTP_transf_2, score 2.7e-15 936155004622 PS01188 GNS1/SUR4 family signature 936155004623 HMMPfam hit to PF00294, PfkB, score 7.1e-42 936155004624 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004625 PS00584 pfkB family of carbohydrate kinases signature 2 936155004626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936155004627 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 936155004628 NAD(P) binding site [chemical binding]; other site 936155004629 active site 936155004630 HMMPfam hit to PF01370, Epimerase, score 2.9e-42 936155004631 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 936155004632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936155004633 active site 936155004634 motif I; other site 936155004635 motif II; other site 936155004636 HMMPfam hit to PF08645, PNK3P, score 0.00027 936155004637 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 936155004638 6 probable transmembrane helices predicted for Hfelis10220 by TMHMM2.0 at aa 7-29, 56-78, 91-113, 135-157, 170-192 and 202-224 936155004639 pantothenate kinase; Reviewed; Region: PRK13333 936155004640 HMMPfam hit to PF03309, Bvg_acc_factor, score 2.5e-12 936155004641 PQQ-like domain; Region: PQQ_2; pfam13360 936155004642 1 probable transmembrane helix predicted for Hfelis10250 by TMHMM2.0 at aa 36-55 936155004643 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 936155004644 trimer interface [polypeptide binding]; other site 936155004645 active site 936155004646 HMMPfam hit to PF00692, dUTPase, score 2.9e-31 936155004647 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 936155004648 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 936155004649 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 936155004650 HMMPfam hit to PF01272, GreA_GreB, score 1.1e-35 936155004651 PS00830 Prokaryotic transcription elongation factors signature 2 936155004652 HMMPfam hit to PF03449, GreA_GreB_N, score 2.1e-40 936155004653 PS00829 Prokaryotic transcription elongation factors signature 1 936155004654 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 936155004655 HMMPfam hit to PF01812, 5-FTHF_cyc-lig, score 1.6e-11 936155004656 phosphodiesterase; Provisional; Region: PRK12704 936155004657 KH domain; Region: KH_1; pfam00013 936155004658 nucleic acid binding region [nucleotide binding]; other site 936155004659 G-X-X-G motif; other site 936155004660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936155004661 Zn2+ binding site [ion binding]; other site 936155004662 Mg2+ binding site [ion binding]; other site 936155004663 HMMPfam hit to PF00013, KH_1, score 5.2e-10 936155004664 HMMPfam hit to PF01966, HD, score 5.3e-20 936155004665 1 probable transmembrane helix predicted for Hfelis10340 by TMHMM2.0 at aa 11-33 936155004666 2 probable transmembrane helices predicted for Hfelis10350 by TMHMM2.0 at aa 12-31 and 41-59 936155004667 1 probable transmembrane helix predicted for Hfelis10360 by TMHMM2.0 at aa 4-26 936155004668 Predicted helix-turn-helix motif with score 1794.000, SD 5.30 at aa 20-41, sequence TTLKEISEKYGVSYRTLTRWRV 936155004669 Predicted helix-turn-helix motif with score 1110.000, SD 2.97 at aa 17-38, sequence GSISHLGTQYSMSPNYIREYYN 936155004670 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 936155004671 HMMPfam hit to PF03681, UPF0150, score 0.00061 936155004672 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 936155004674 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 936155004675 Probable transposase; Region: OrfB_IS605; pfam01385 936155004676 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 936155004677 HMMPfam hit to PF07282, Transposase_35, score 7.2e-30 936155004678 HMMPfam hit to PF01385, Transposase_2, score 9.9e-53 936155004679 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 936155004680 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.6e-21 936155004681 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 936155004682 dimerization interface [polypeptide binding]; other site 936155004683 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 936155004684 ATP binding site [chemical binding]; other site 936155004685 HMMPfam hit to PF02769, AIRS_C, score 5.3e-28 936155004686 HMMPfam hit to PF00586, AIRS, score 2.1e-17 936155004687 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 936155004688 Acylphosphatase; Region: Acylphosphatase; pfam00708 936155004689 HypF finger; Region: zf-HYPF; pfam07503 936155004690 HypF finger; Region: zf-HYPF; pfam07503 936155004691 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 936155004692 PS00107 Protein kinases ATP-binding region signature 936155004693 HMMPfam hit to PF01300, Sua5_yciO_yrdC, score 1.1e-42 936155004694 HMMPfam hit to PF07503, zf-HYPF, score 3.3e-12 936155004695 HMMPfam hit to PF07503, zf-HYPF, score 5e-13 936155004696 HMMPfam hit to PF00708, Acylphosphatase, score 1.8e-18 936155004697 PS00150 Acylphosphatase signature 1 936155004698 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 936155004699 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 936155004700 HMMPfam hit to PF04371, PAD_porph, score 8.2e-107 936155004701 UGMP family protein; Validated; Region: PRK09604 936155004702 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 936155004703 HMMPfam hit to PF00814, Peptidase_M22, score 6.3e-49 936155004704 PS01016 Glycoprotease family signature 936155004705 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 936155004706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936155004707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155004708 dimer interface [polypeptide binding]; other site 936155004709 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 936155004710 putative CheW interface [polypeptide binding]; other site 936155004711 2 probable transmembrane helices predicted for Hfelis10550 by TMHMM2.0 at aa 10-28 and 180-199 936155004712 HMMPfam hit to PF00672, HAMP, score 2.7e-09 936155004713 HMMPfam hit to PF00015, MCPsignal, score 2.6e-32 936155004714 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 936155004715 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 936155004716 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 936155004717 HMMPfam hit to PF01134, GIDA, score 2.5e-243 936155004718 PS01280 Glucose inhibited division protein A family signature 1 936155004719 PS01281 Glucose inhibited division protein A family signature 2 936155004720 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 936155004721 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 936155004722 metal binding site [ion binding]; metal-binding site 936155004723 dimer interface [polypeptide binding]; other site 936155004724 HMMPfam hit to PF01546, Peptidase_M20, score 1.3e-41 936155004725 HMMPfam hit to PF07687, M20_dimer, score 1e-15 936155004726 Predicted helix-turn-helix motif with score 1563.000, SD 4.51 at aa 236-257, sequence TSLKSISDAENVTPQTLEICFN 936155004727 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 936155004728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 936155004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155004730 active site 936155004731 phosphorylation site [posttranslational modification] 936155004732 intermolecular recognition site; other site 936155004733 dimerization interface [polypeptide binding]; other site 936155004734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936155004735 DNA binding site [nucleotide binding] 936155004736 HMMPfam hit to PF00486, Trans_reg_C, score 4e-20 936155004737 HMMPfam hit to PF00072, Response_reg, score 7e-16 936155004738 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 936155004739 HMMPfam hit to PF03349, Toluene_X, score 8.6e-09 936155004740 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004741 LPP20 lipoprotein; Region: LPP20; cl15824 936155004742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 936155004743 HMMPfam hit to PF04164, DUF400, score 2e-40 936155004744 1 probable transmembrane helix predicted for Hfelis10620 by TMHMM2.0 at aa 13-31 936155004745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004746 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 936155004747 HMMPfam hit to PF03553, Na_H_antiporter, score 1.7e-42 936155004748 11 probable transmembrane helices predicted for Hfelis10630 by TMHMM2.0 at aa 15-37, 42-64, 84-103, 124-146, 161-183, 204-226, 246-279, 300-322, 337-359, 380-402 and 412-434 936155004749 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 936155004750 1 probable transmembrane helix predicted for Hfelis10640 by TMHMM2.0 at aa 7-29 936155004751 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004752 HMMPfam hit to PF02169, LPP20, score 1.8e-51 936155004753 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004754 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 936155004755 HMMPfam hit to PF01084, Ribosomal_S18, score 1.5e-27 936155004756 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936155004757 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936155004758 dimer interface [polypeptide binding]; other site 936155004759 ssDNA binding site [nucleotide binding]; other site 936155004760 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936155004761 HMMPfam hit to PF00436, SSB, score 1.1e-26 936155004762 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 936155004763 HMMPfam hit to PF01250, Ribosomal_S6, score 1.4e-39 936155004764 PS01048 Ribosomal protein S6 signature 936155004765 DNA polymerase III subunit delta; Validated; Region: PRK08487 936155004766 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 936155004767 HMMPfam hit to PF06144, DNA_pol3_delta, score 0.00011 936155004768 fumarate hydratase; Reviewed; Region: fumC; PRK00485 936155004769 Class II fumarases; Region: Fumarase_classII; cd01362 936155004770 active site 936155004771 tetramer interface [polypeptide binding]; other site 936155004772 HMMPfam hit to PF10415, FumaraseC_C, score 3.2e-31 936155004773 HMMPfam hit to PF00206, Lyase_1, score 8e-179 936155004774 PS00163 Fumarate lyases signature 936155004775 YtkA-like; Region: YtkA; pfam13115 936155004776 Outer membrane efflux protein; Region: OEP; pfam02321 936155004777 PS00430 TonB-dependent receptor proteins signature 1 936155004778 HMMPfam hit to PF02321, OEP, score 8.7e-13 936155004779 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 936155004780 HlyD family secretion protein; Region: HlyD_3; pfam13437 936155004781 putative membrane fusion protein; Region: TIGR02828 936155004782 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 936155004783 HMMPfam hit to PF00873, ACR_tran, score 1.4e-164 936155004784 12 probable transmembrane helices predicted for Hfelis10750 by TMHMM2.0 at aa 12-31, 332-354, 356-378, 383-405, 434-456, 471-493, 520-542, 856-878, 885-907, 912-934, 971-990 and 1000-1022 936155004785 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004786 HMMPfam hit to PF01856, HP_OMP, score 9.7e-50 936155004787 succinic semialdehyde dehydrogenase; Region: PLN02278 936155004788 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 936155004789 tetramerization interface [polypeptide binding]; other site 936155004790 NAD(P) binding site [chemical binding]; other site 936155004791 catalytic residues [active] 936155004792 HMMPfam hit to PF00171, Aldedh, score 1e-226 936155004793 PS00070 Aldehyde dehydrogenases cysteine active site 936155004794 PS00687 Aldehyde dehydrogenases glutamic acid active site 936155004795 Predicted helix-turn-helix motif with score 1190.000, SD 3.24 at aa 26-47, sequence ATLQEIAYVKSVSQEQVEQIIS 936155004796 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 936155004797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936155004798 inhibitor-cofactor binding pocket; inhibition site 936155004799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155004800 catalytic residue [active] 936155004801 HMMPfam hit to PF00202, Aminotran_3, score 1.1e-125 936155004802 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site 936155004803 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004804 Uncharacterized conserved protein [Function unknown]; Region: COG3287 936155004805 FIST N domain; Region: FIST; pfam08495 936155004806 FIST C domain; Region: FIST_C; pfam10442 936155004807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155004808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155004809 dimer interface [polypeptide binding]; other site 936155004810 putative CheW interface [polypeptide binding]; other site 936155004811 HMMPfam hit to PF00015, MCPsignal, score 2.8e-21 936155004812 HMMPfam hit to PF10442, FIST_C, score 1.8e-25 936155004813 HMMPfam hit to PF08495, FIST, score 2.1e-06 936155004814 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 936155004815 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936155004816 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936155004817 HMMPfam hit to PF06429, DUF1078, score 2.5e-22 936155004818 HMMPfam hit to PF00460, Flg_bb_rod, score 3.1e-11 936155004819 PS00588 Flagella basal body rod proteins signature 936155004820 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004821 HMMPfam hit to PF01856, HP_OMP, score 9.6e-46 936155004822 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004823 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004824 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 936155004825 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 936155004826 HMMPfam hit to PF00311, PEPcase, score 7.7e-16 936155004827 PS00393 Phosphoenolpyruvate carboxylase active site 2 936155004828 PS00781 Phosphoenolpyruvate carboxylase active site 1 936155004829 ketol-acid reductoisomerase; Provisional; Region: PRK05479 936155004830 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 936155004831 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 936155004832 HMMPfam hit to PF07991, IlvN, score 1.4e-84 936155004833 HMMPfam hit to PF01450, IlvC, score 1.8e-53 936155004834 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 936155004835 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 936155004836 Switch I; other site 936155004837 Switch II; other site 936155004838 HMMPfam hit to PF01656, CbiA, score 1.6e-30 936155004839 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004840 Septum formation topological specificity factor MinE; Region: MinE; cl00538 936155004841 HMMPfam hit to PF03776, MinE, score 1.6e-17 936155004842 DNA protecting protein DprA; Region: dprA; TIGR00732 936155004843 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 936155004844 HMMPfam hit to PF02481, DNA_processg_A, score 9.2e-59 936155004845 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 936155004846 HMMPfam hit to PF03652, UPF0081, score 4.2e-15 936155004847 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 936155004848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155004849 RNA binding surface [nucleotide binding]; other site 936155004850 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936155004851 active site 936155004852 HMMPfam hit to PF01479, S4, score 3.2e-05 936155004853 HMMPfam hit to PF00849, PseudoU_synth_2, score 9.1e-45 936155004854 PS01129 Rlu family of pseudouridine synthase signature 936155004855 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 936155004856 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 936155004857 Interdomain contacts; other site 936155004858 Cytokine receptor motif; other site 936155004859 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 936155004860 Interdomain contacts; other site 936155004861 Cytokine receptor motif; other site 936155004862 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 936155004863 Interdomain contacts; other site 936155004864 Cytokine receptor motif; other site 936155004865 HMMPfam hit to PF00041, fn3, score 0.0016 936155004866 HMMPfam hit to PF00041, fn3, score 0.00057 936155004867 Putative methyltransferase; Region: Methyltransf_4; cl17290 936155004868 HMMPfam hit to PF02390, Methyltransf_4, score 1.5e-36 936155004869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936155004870 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 936155004871 Walker A/P-loop; other site 936155004872 ATP binding site [chemical binding]; other site 936155004873 Q-loop/lid; other site 936155004874 ABC transporter signature motif; other site 936155004875 Walker B; other site 936155004876 D-loop; other site 936155004877 H-loop/switch region; other site 936155004878 HMMPfam hit to PF00005, ABC_tran, score 2e-43 936155004879 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004880 PS00211 ABC transporters family signature 936155004881 4 probable transmembrane helices predicted for Hfelis10930 by TMHMM2.0 at aa 7-29, 151-173, 194-216 and 245-264 936155004882 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 936155004883 Peptidase family M23; Region: Peptidase_M23; pfam01551 936155004884 HMMPfam hit to PF01551, Peptidase_M23, score 3.9e-16 936155004885 FlaG protein; Region: FlaG; cl00591 936155004886 HMMPfam hit to PF03646, FlaG, score 2.8e-24 936155004887 flagellar capping protein; Validated; Region: fliD; PRK08453 936155004888 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 936155004889 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 936155004890 HMMPfam hit to PF02465, FliD_N, score 2.3e-18 936155004891 HMMPfam hit to PF07196, Flagellin_IN, score 4.6e-10 936155004892 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004893 HMMPfam hit to PF07195, FliD_C, score 2.8e-66 936155004894 flagellar protein FliS; Validated; Region: fliS; PRK05685 936155004895 HMMPfam hit to PF02561, FliS, score 9.3e-56 936155004896 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155004897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 936155004898 TPR motif; other site 936155004899 binding surface 936155004900 HMMPfam hit to PF08238, Sel1, score 1.9 936155004901 HMMPfam hit to PF08238, Sel1, score 0.0033 936155004902 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155004903 HMMPfam hit to PF01856, HP_OMP, score 2.2e-35 936155004904 4 probable transmembrane helices predicted for Hfelis11000 by TMHMM2.0 at aa 7-25, 72-94, 107-129 and 144-166 936155004905 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155004906 Sel1 repeat; Region: Sel1; cl02723 936155004907 HMMPfam hit to PF08238, Sel1, score 3.2e-11 936155004908 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 936155004909 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936155004910 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936155004911 metal-binding site [ion binding] 936155004912 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936155004913 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936155004914 7 probable transmembrane helices predicted for Hfelis11030 by TMHMM2.0 at aa 172-194, 209-231, 243-262, 267-284, 425-444, 454-476 and 750-772 936155004915 HMMPfam hit to PF00702, Hydrolase, score 1.4e-17 936155004916 PS00154 E1-E2 ATPases phosphorylation site 936155004917 HMMPfam hit to PF00122, E1-E2_ATPase, score 1.1e-62 936155004918 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004919 HMMPfam hit to PF00403, HMA, score 1.1e-09 936155004920 PS01047 Heavy-metal-associated domain 936155004921 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 936155004922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155004923 HMMPfam hit to PF05175, MTS, score 0.00013 936155004924 PS00092 N-6 Adenine-specific DNA methylases signature 936155004925 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 936155004926 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 936155004927 catalytic motif [active] 936155004928 Zn binding site [ion binding]; other site 936155004929 HMMPfam hit to PF00383, dCMP_cyt_deam_1, score 1.5e-19 936155004930 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 936155004931 12 probable transmembrane helices predicted for Hfelis11060 by TMHMM2.0 at aa 12-31, 41-59, 66-88, 103-125, 132-154, 169-191, 222-244, 254-276, 288-310, 315-337, 349-371 and 381-403 936155004932 HMMPfam hit to PF03616, Glt_symporter, score 6.9e-216 936155004933 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 936155004934 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 936155004935 NAD(P) binding pocket [chemical binding]; other site 936155004936 HMMPfam hit to PF03435, Saccharop_dh, score 6.9e-162 936155004937 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004938 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936155004939 9 probable transmembrane helices predicted for Hfelis11080 by TMHMM2.0 at aa 5-24, 37-54, 69-91, 119-141, 145-167, 178-200, 215-237, 244-266 and 271-290 936155004940 HMMPfam hit to PF00892, DUF6, score 1.4e-08 936155004941 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 936155004942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 936155004943 HMMPfam hit to PF01547, SBP_bac_1, score 3.9e-11 936155004944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936155004945 putative PBP binding loops; other site 936155004946 ABC-ATPase subunit interface; other site 936155004947 HMMPfam hit to PF00528, BPD_transp_1, score 6.9e-16 936155004948 5 probable transmembrane helices predicted for Hfelis11100 by TMHMM2.0 at aa 13-35, 47-69, 84-106, 147-169 and 194-216 936155004949 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004950 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 936155004951 thiamine phosphate binding site [chemical binding]; other site 936155004952 active site 936155004953 pyrophosphate binding site [ion binding]; other site 936155004954 HMMPfam hit to PF02581, TMP-TENI, score 0.00047 936155004955 2 probable transmembrane helices predicted for Hfelis11120 by TMHMM2.0 at aa 10-32 and 39-58 936155004956 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 936155004957 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 936155004958 6 probable transmembrane helices predicted for Hfelis11130 by TMHMM2.0 at aa 18-40, 77-99, 103-122, 134-156, 176-198 and 205-222 936155004959 HMMPfam hit to PF00119, ATP-synt_A, score 2e-35 936155004960 PS00449 ATP synthase a subunit signature 936155004961 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 936155004962 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 936155004963 HMMPfam hit to PF03807, F420_oxidored, score 2.3e-22 936155004964 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature 936155004965 flagellar assembly protein FliW; Provisional; Region: PRK13282 936155004966 HMMPfam hit to PF02623, FliW, score 2.8e-39 936155004967 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 936155004968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155004969 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 936155004970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155004971 Walker A motif; other site 936155004972 ATP binding site [chemical binding]; other site 936155004973 Walker B motif; other site 936155004974 arginine finger; other site 936155004975 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 936155004976 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936155004977 HMMPfam hit to PF02190, LON, score 3.6e-42 936155004978 HMMPfam hit to PF00004, AAA, score 1.7e-52 936155004979 PS00017 ATP/GTP-binding site motif A (P-loop) 936155004980 HMMPfam hit to PF05362, Lon_C, score 1.5e-101 936155004981 PS01046 ATP-dependent serine proteases, lon family, serine active site 936155004982 prephenate dehydrogenase; Validated; Region: PRK08507 936155004983 Prephenate dehydrogenase; Region: PDH; pfam02153 936155004984 HMMPfam hit to PF02153, PDH, score 3.3e-83 936155004985 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 936155004986 HMMPfam hit to PF01313, Bac_export_3, score 2.3e-40 936155004987 2 probable transmembrane helices predicted for Hfelis11190 by TMHMM2.0 at aa 15-37 and 50-72 936155004988 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 936155004989 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 936155004990 PS00592 Glycosyl hydrolases family 9 active sites signature 1 936155004991 HMMPfam hit to PF02873, MurB_C, score 3.3e-40 936155004992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936155004993 HMMPfam hit to PF00753, Lactamase_B, score 1.4e-26 936155004994 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 936155004995 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 936155004996 ATP binding site [chemical binding]; other site 936155004997 substrate interface [chemical binding]; other site 936155004998 HMMPfam hit to PF00899, ThiF, score 8e-60 936155004999 1 probable transmembrane helix predicted for Hfelis11230 by TMHMM2.0 at aa 32-54 936155005000 HMMPfam hit to PF05237, MoeZ_MoeB, score 1e-29 936155005001 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005002 flagellar motor protein MotA; Validated; Region: PRK08456 936155005003 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 936155005004 PS00430 TonB-dependent receptor proteins signature 1 936155005005 4 probable transmembrane helices predicted for Hfelis11240 by TMHMM2.0 at aa 5-24, 28-50, 147-169 and 179-201 936155005006 HMMPfam hit to PF01618, MotA_ExbB, score 2.6e-14 936155005007 PS01307 Flagellar motor protein motA family signature 936155005008 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 936155005009 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936155005010 ligand binding site [chemical binding]; other site 936155005011 1 probable transmembrane helix predicted for Hfelis11250 by TMHMM2.0 at aa 18-40 936155005012 HMMPfam hit to PF00691, OmpA, score 7.5e-07 936155005013 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 936155005014 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936155005015 HMMPfam hit to PF01580, FtsK_SpoIIIE, score 6.1e-72 936155005016 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005017 4 probable transmembrane helices predicted for Hfelis11270 by TMHMM2.0 at aa 20-42, 52-74, 81-103 and 118-140 936155005018 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 936155005019 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 936155005020 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 936155005021 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936155005022 TPP-binding site [chemical binding]; other site 936155005023 dimer interface [polypeptide binding]; other site 936155005024 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936155005025 PYR/PP interface [polypeptide binding]; other site 936155005026 dimer interface [polypeptide binding]; other site 936155005027 TPP binding site [chemical binding]; other site 936155005028 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005029 HMMPfam hit to PF02780, Transketolase_C, score 5.9e-08 936155005030 HMMPfam hit to PF02779, Transket_pyr, score 3.2e-60 936155005031 PS00802 Transketolase signature 2 936155005032 HMMPfam hit to PF00456, Transketolase_N, score 2.6e-140 936155005033 PS00801 Transketolase signature 1 936155005034 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 936155005035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936155005036 active site 936155005037 nucleotide binding site [chemical binding]; other site 936155005038 HIGH motif; other site 936155005039 KMSKS motif; other site 936155005040 Riboflavin kinase; Region: Flavokinase; pfam01687 936155005041 HMMPfam hit to PF01687, Flavokinase, score 2.4e-37 936155005042 HMMPfam hit to PF06574, FAD_syn, score 7.3e-09 936155005043 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 936155005044 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155005045 RNA binding surface [nucleotide binding]; other site 936155005046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155005047 S-adenosylmethionine binding site [chemical binding]; other site 936155005048 HMMPfam hit to PF01728, FtsJ, score 2.5e-07 936155005049 HMMPfam hit to PF01479, S4, score 4.7e-12 936155005050 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005051 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 936155005052 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936155005053 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936155005054 HMMPfam hit to PF02729, OTCace_N, score 7.9e-28 936155005055 PS00097 Aspartate and ornithine carbamoyltransferases signature 936155005056 HMMPfam hit to PF00185, OTCace, score 5.4e-19 936155005057 Cache domain; Region: Cache_2; cl07034 936155005058 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155005059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936155005060 dimerization interface [polypeptide binding]; other site 936155005061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155005062 dimer interface [polypeptide binding]; other site 936155005063 putative CheW interface [polypeptide binding]; other site 936155005064 2 probable transmembrane helices predicted for Hfelis11340 by TMHMM2.0 at aa 10-32 and 210-232 936155005065 PS00011 Vitamin K-dependent carboxylation domain 936155005066 HMMPfam hit to PF00672, HAMP, score 3.3e-06 936155005067 HMMPfam hit to PF00015, MCPsignal, score 1.4e-27 936155005068 Class I aldolases; Region: Aldolase_Class_I; cl17187 936155005069 transaldolase; Provisional; Region: PRK03903 936155005070 catalytic residue [active] 936155005071 HMMPfam hit to PF00923, Transaldolase, score 6.2e-38 936155005072 PS01054 Transaldolase signature 1 936155005073 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 936155005074 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936155005075 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936155005076 HMMPfam hit to PF02875, Mur_ligase_C, score 2e-23 936155005077 HMMPfam hit to PF08245, Mur_ligase_M, score 2.6e-49 936155005078 PS01011 Folylpolyglutamate synthase signature 1 936155005079 NifU-like domain; Region: NifU; cl00484 936155005080 HMMPfam hit to PF01106, NifU, score 5.6e-32 936155005081 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 936155005082 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 936155005083 HMMPfam hit to PF00398, RrnaAD, score 1.5e-26 936155005084 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 936155005085 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 936155005086 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 936155005087 HMMPfam hit to PF00753, Lactamase_B, score 2.5e-23 936155005088 HMMPfam hit to PF07521, RMMBL, score 2.6e-12 936155005089 PS01292 Uncharacterized protein family UPF0036 signature 936155005090 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 936155005091 methionine sulfoxide reductase B; Provisional; Region: PRK00222 936155005092 SelR domain; Region: SelR; pfam01641 936155005093 HMMPfam hit to PF01625, PMSR, score 8.7e-90 936155005094 HMMPfam hit to PF01641, SelR, score 2.6e-85 936155005095 KpsF/GutQ family protein; Region: kpsF; TIGR00393 936155005096 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 936155005097 putative active site [active] 936155005098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 936155005099 HMMPfam hit to PF01380, SIS, score 9e-26 936155005100 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005101 HMMPfam hit to PF00571, CBS, score 4.4e-18 936155005102 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 936155005103 HMMPfam hit to PF10398, DUF2443, score 1e-38 936155005104 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 936155005105 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 936155005106 glutaminase active site [active] 936155005107 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 936155005108 dimer interface [polypeptide binding]; other site 936155005109 active site 936155005110 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936155005111 dimer interface [polypeptide binding]; other site 936155005112 active site 936155005113 HMMPfam hit to PF00310, GATase_2, score 7.2e-25 936155005114 HMMPfam hit to PF01380, SIS, score 2.1e-26 936155005115 HMMPfam hit to PF01380, SIS, score 5.1e-07 936155005116 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 936155005117 HMMPfam hit to PF01755, Glyco_transf_25, score 5e-19 936155005118 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 936155005119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155005120 FeS/SAM binding site; other site 936155005121 HMMPfam hit to PF04055, Radical_SAM, score 2.1e-13 936155005122 1 probable transmembrane helix predicted for Hfelis11480 by TMHMM2.0 at aa 7-29 936155005123 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005124 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 936155005125 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 936155005126 NAD binding site [chemical binding]; other site 936155005127 HMMPfam hit to PF01262, AlaDh_PNT_C, score 8.3e-50 936155005128 HMMPfam hit to PF05222, AlaDh_PNT_N, score 9.4e-43 936155005129 Arginase family; Region: Arginase; cd09989 936155005130 active site 936155005131 Mn binding site [ion binding]; other site 936155005132 oligomer interface [polypeptide binding]; other site 936155005133 HMMPfam hit to PF00491, Arginase, score 6.2e-35 936155005134 PS00148 Arginase family signature 2 936155005135 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 936155005136 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 936155005137 HMMPfam hit to PF03746, LamB_YcsF, score 8.6e-96 936155005138 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936155005139 carboxyltransferase (CT) interaction site; other site 936155005140 biotinylation site [posttranslational modification]; other site 936155005141 HMMPfam hit to PF00364, Biotin_lipoyl, score 1.4e-26 936155005142 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 936155005143 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936155005144 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155005145 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936155005146 HMMPfam hit to PF00289, CPSase_L_chain, score 7.6e-41 936155005147 HMMPfam hit to PF02786, CPSase_L_D2, score 3.7e-93 936155005148 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 936155005149 HMMPfam hit to PF02785, Biotin_carb_C, score 3.6e-55 936155005150 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 936155005151 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 936155005152 HMMPfam hit to PF02682, AHS1, score 1.8e-07 936155005153 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 936155005154 HMMPfam hit to PF02626, AHS2, score 6.7e-117 936155005155 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005156 elongation factor P; Validated; Region: PRK00529 936155005157 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 936155005158 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 936155005159 RNA binding site [nucleotide binding]; other site 936155005160 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 936155005161 RNA binding site [nucleotide binding]; other site 936155005162 HMMPfam hit to PF09285, Elong-fact-P_C, score 4.3e-32 936155005163 PS01275 Elongation factor P signature 936155005164 HMMPfam hit to PF01132, EFP, score 3.7e-28 936155005165 HMMPfam hit to PF08207, EFP_N, score 3.4e-31 936155005166 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 936155005167 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 936155005168 intersubunit interface [polypeptide binding]; other site 936155005169 active site 936155005170 zinc binding site [ion binding]; other site 936155005171 Na+ binding site [ion binding]; other site 936155005172 HMMPfam hit to PF01116, F_bP_aldolase, score 3.9e-167 936155005173 PS00806 Fructose-bisphosphate aldolase class-II signature 2 936155005174 PS00602 Fructose-bisphosphate aldolase class-II signature 1 936155005175 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 936155005176 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 936155005177 HMMPfam hit to PF00639, Rotamase, score 3.4e-18 936155005178 1 probable transmembrane helix predicted for Hfelis11600 by TMHMM2.0 at aa 7-29 936155005179 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 936155005180 5 probable transmembrane helices predicted for Hfelis11610 by TMHMM2.0 at aa 21-43, 58-80, 87-109, 141-163 and 204-226 936155005181 HMMPfam hit to PF04401, DUF540, score 4.7e-07 936155005182 CrcB-like protein; Region: CRCB; cl09114 936155005183 HMMPfam hit to PF02537, CRCB, score 1.8e-45 936155005184 4 probable transmembrane helices predicted for Hfelis11620 by TMHMM2.0 at aa 4-23, 36-58, 68-87 and 100-122 936155005185 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 936155005186 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 936155005187 active site 936155005188 HMMPfam hit to PF02602, HEM4, score 2.4e-06 936155005189 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936155005190 active site residue [active] 936155005191 HMMPfam hit to PF00581, Rhodanese, score 6.3e-10 936155005192 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 936155005193 FAD binding domain; Region: FAD_binding_4; pfam01565 936155005194 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936155005195 HMMPfam hit to PF01565, FAD_binding_4, score 2.5e-32 936155005196 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005197 HMMPfam hit to PF02913, FAD-oxidase_C, score 3.1e-40 936155005198 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155005199 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155005200 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 936155005201 PS00226 Intermediate filaments signature 936155005202 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 936155005203 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 936155005204 catalytic residue [active] 936155005205 putative FPP diphosphate binding site; other site 936155005206 putative FPP binding hydrophobic cleft; other site 936155005207 dimer interface [polypeptide binding]; other site 936155005208 putative IPP diphosphate binding site; other site 936155005209 HMMPfam hit to PF01255, Prenyltransf, score 1.6e-110 936155005210 PS01066 Undecaprenyl pyrophosphate synthetase family signature 936155005211 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 936155005212 HMMPfam hit to PF00702, Hydrolase, score 4.7e-11 936155005213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936155005214 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 936155005215 Walker A/P-loop; other site 936155005216 ATP binding site [chemical binding]; other site 936155005217 Q-loop/lid; other site 936155005218 ABC transporter signature motif; other site 936155005219 Walker B; other site 936155005220 D-loop; other site 936155005221 H-loop/switch region; other site 936155005222 HMMPfam hit to PF00005, ABC_tran, score 1.4e-58 936155005223 PS00211 ABC transporters family signature 936155005224 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005225 5 probable transmembrane helices predicted for Hfelis11680 by TMHMM2.0 at aa 33-55, 89-111, 165-187, 192-211 and 275-297 936155005226 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 936155005227 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 936155005228 dimer interface [polypeptide binding]; other site 936155005229 decamer (pentamer of dimers) interface [polypeptide binding]; other site 936155005230 catalytic triad [active] 936155005231 peroxidatic and resolving cysteines [active] 936155005232 HMMPfam hit to PF00578, AhpC-TSA, score 1.2e-52 936155005233 HMMPfam hit to PF10417, 1-cysPrx_C, score 6.1e-24 936155005234 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155005235 HMMPfam hit to PF01856, HP_OMP, score 4.6e-28 936155005236 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 936155005237 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 936155005238 5S rRNA interface [nucleotide binding]; other site 936155005239 CTC domain interface [polypeptide binding]; other site 936155005240 L16 interface [polypeptide binding]; other site 936155005241 HMMPfam hit to PF01386, Ribosomal_L25p, score 4.1e-19 936155005242 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 936155005243 putative active site [active] 936155005244 catalytic residue [active] 936155005245 HMMPfam hit to PF01195, Pept_tRNA_hydro, score 2.8e-67 936155005246 PS01195 Peptidyl-tRNA hydrolase signature 1 936155005247 PS01196 Peptidyl-tRNA hydrolase signature 2 936155005248 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 936155005249 Predicted permeases [General function prediction only]; Region: COG0795 936155005250 HMMPfam hit to PF03739, YjgP_YjgQ, score 7.2e-32 936155005251 6 probable transmembrane helices predicted for Hfelis11730 by TMHMM2.0 at aa 7-29, 55-77, 98-120, 263-285, 297-319 and 323-345 936155005252 DpnII restriction endonuclease; Region: DpnII; pfam04556 936155005253 HMMPfam hit to PF04556, DpmII, score 8.8e-98 936155005254 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155005255 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155005256 HMMPfam hit to PF01555, N6_N4_Mtase, score 3.9e-76 936155005257 PS00092 N-6 Adenine-specific DNA methylases signature 936155005258 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 936155005259 HMMPfam hit to PF00852, Glyco_transf_10, score 2.6e-06 936155005260 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 936155005261 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936155005262 HMMPfam hit to PF06429, DUF1078, score 3.3e-17 936155005263 HMMPfam hit to PF00460, Flg_bb_rod, score 4.5e-05 936155005264 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 936155005265 1 probable transmembrane helix predicted for Hfelis11810 by TMHMM2.0 at aa 9-31 936155005266 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 936155005267 Peptidase family M23; Region: Peptidase_M23; pfam01551 936155005268 HMMPfam hit to PF01551, Peptidase_M23, score 1.7e-48 936155005269 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 936155005270 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 936155005271 dimer interface [polypeptide binding]; other site 936155005272 ADP-ribose binding site [chemical binding]; other site 936155005273 active site 936155005274 nudix motif; other site 936155005275 metal binding site [ion binding]; metal-binding site 936155005276 HMMPfam hit to PF00293, NUDIX, score 1.1e-13 936155005277 FAD binding domain; Region: FAD_binding_4; pfam01565 936155005278 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 936155005279 HMMPfam hit to PF01565, FAD_binding_4, score 7.1e-55 936155005280 HMMPfam hit to PF02913, FAD-oxidase_C, score 1.8e-70 936155005281 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 936155005282 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936155005283 DNA binding site [nucleotide binding] 936155005284 active site 936155005285 HMMPfam hit to PF01035, DNA_binding_1, score 2.7e-45 936155005286 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site 936155005287 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 936155005288 Predicted dehydrogenase [General function prediction only]; Region: COG0579 936155005289 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005290 HMMPfam hit to PF01266, DAO, score 3.2e-07 936155005291 1 probable transmembrane helix predicted for Hfelis11870 by TMHMM2.0 at aa 7-24 936155005292 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005293 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 936155005294 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 936155005295 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936155005296 NlpC/P60 family; Region: NLPC_P60; cl17555 936155005297 HMMPfam hit to PF00877, NLPC_P60, score 7.1e-10 936155005298 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 936155005299 Low molecular weight phosphatase family; Region: LMWPc; cd00115 936155005300 active site 936155005301 HMMPfam hit to PF01451, LMWPc, score 5.6e-27 936155005302 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 936155005303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936155005304 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936155005305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936155005306 DNA binding residues [nucleotide binding] 936155005307 HMMPfam hit to PF04545, Sigma70_r4, score 1.4e-23 936155005308 PS00716 Sigma-70 factors family signature 2 936155005309 Predicted helix-turn-helix motif with score 2012.000, SD 6.04 at aa 579-600, sequence RTLEEIGKELNVTRERVRQIES 936155005310 HMMPfam hit to PF04539, Sigma70_r3, score 2.5e-29 936155005311 HMMPfam hit to PF04542, Sigma70_r2, score 3.1e-27 936155005312 PS00715 Sigma-70 factors family signature 1 936155005313 HMMPfam hit to PF00140, Sigma70_r1_2, score 1.6e-16 936155005314 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 936155005315 HMMPfam hit to PF02416, MttA_Hcf106, score 0.0011 936155005316 1 probable transmembrane helix predicted for Hfelis11910 by TMHMM2.0 at aa 4-21 936155005317 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 936155005318 HMMPfam hit to PF00902, TatC, score 1.2e-79 936155005319 6 probable transmembrane helices predicted for Hfelis11920 by TMHMM2.0 at aa 16-38, 64-86, 98-120, 147-169, 181-198 and 208-230 936155005320 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 936155005321 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 936155005322 HMMPfam hit to PF02547, Queuosine_synth, score 5.2e-82 936155005323 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 936155005324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155005325 S-adenosylmethionine binding site [chemical binding]; other site 936155005326 HMMPfam hit to PF02527, GidB, score 1.1e-46 936155005327 urease subunit alpha; Provisional; Region: PRK13986 936155005328 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 936155005329 alpha-gamma subunit interface [polypeptide binding]; other site 936155005330 beta-gamma subunit interface [polypeptide binding]; other site 936155005331 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 936155005332 alpha-beta subunit interface [polypeptide binding]; other site 936155005333 HMMPfam hit to PF00547, Urease_gamma, score 2.7e-90 936155005334 HMMPfam hit to PF00699, Urease_beta, score 1.3e-76 936155005335 urease subunit alpha; Reviewed; Region: ureC; PRK13207 936155005336 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 936155005337 subunit interactions [polypeptide binding]; other site 936155005338 active site 936155005339 flap region; other site 936155005340 HMMPfam hit to PF00449, Urease_alpha, score 8.2e-92 936155005341 HMMPfam hit to PF01979, Amidohydro_1, score 1.5e-100 936155005342 PS01120 Urease nickel ligands signature 936155005343 PS00145 Urease active site 936155005344 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 936155005345 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 936155005346 HMMPfam hit to PF02293, AmiS_UreI, score 3.6e-96 936155005347 6 probable transmembrane helices predicted for Hfelis11990 by TMHMM2.0 at aa 5-24, 31-53, 68-90, 103-125, 140-162 and 169-191 936155005348 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 936155005349 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 936155005350 dimer interface [polypeptide binding]; other site 936155005351 catalytic residues [active] 936155005352 HMMPfam hit to PF02814, UreE_N, score 1e-13 936155005353 HMMPfam hit to PF05194, UreE_C, score 7e-15 936155005354 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 936155005355 UreF; Region: UreF; pfam01730 936155005356 HMMPfam hit to PF01730, UreF, score 1.2e-40 936155005357 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005358 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 936155005359 G1 box; other site 936155005360 GTP/Mg2+ binding site [chemical binding]; other site 936155005361 G2 box; other site 936155005362 Switch I region; other site 936155005363 G3 box; other site 936155005364 Switch II region; other site 936155005365 G4 box; other site 936155005366 G5 box; other site 936155005367 HMMPfam hit to PF02492, cobW, score 6.6e-77 936155005368 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005369 UreD urease accessory protein; Region: UreD; cl00530 936155005370 HMMPfam hit to PF01774, UreD, score 8.9e-61 936155005371 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 936155005372 7 probable transmembrane helices predicted for Hfelis12040 by TMHMM2.0 at aa 4-25, 73-95, 110-132, 167-189, 204-226, 249-271 and 298-317 936155005373 HMMPfam hit to PF03824, NicO, score 9e-91 936155005374 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 936155005375 7 probable transmembrane helices predicted for Hfelis12050 by TMHMM2.0 at aa 4-26, 73-95, 110-132, 168-190, 205-227, 250-272 and 299-318 936155005376 HMMPfam hit to PF03824, NicO, score 3.8e-112 936155005377 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 936155005378 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 936155005379 putative metal binding site [ion binding]; other site 936155005380 HMMPfam hit to PF02342, TerD, score 3.1e-55 936155005381 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 936155005382 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 936155005383 putative metal binding site [ion binding]; other site 936155005384 HMMPfam hit to PF02342, TerD, score 1.7e-24 936155005385 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 936155005386 HD domain; Region: HD_3; pfam13023 936155005387 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155005388 HMMPfam hit to PF01856, HP_OMP, score 4e-14 936155005389 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 936155005390 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 936155005391 trmE is a tRNA modification GTPase; Region: trmE; cd04164 936155005392 G1 box; other site 936155005393 GTP/Mg2+ binding site [chemical binding]; other site 936155005394 Switch I region; other site 936155005395 G2 box; other site 936155005396 Switch II region; other site 936155005397 G3 box; other site 936155005398 G4 box; other site 936155005399 G5 box; other site 936155005400 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 936155005401 HMMPfam hit to PF01926, MMR_HSR1, score 2.7e-41 936155005402 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005403 HMMPfam hit to PF10396, TrmE_N, score 2.1e-66 936155005404 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 936155005405 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 936155005406 G-X-X-G motif; other site 936155005407 membrane protein insertase; Provisional; Region: PRK01318 936155005408 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 936155005409 HMMPfam hit to PF02096, 60KD_IMP, score 2.8e-108 936155005410 5 probable transmembrane helices predicted for Hfelis12130 by TMHMM2.0 at aa 7-26, 344-366, 409-431, 446-468 and 489-511 936155005411 Haemolytic domain; Region: Haemolytic; pfam01809 936155005412 HMMPfam hit to PF01809, DUF37, score 3.7e-21 936155005413 Ribonuclease P; Region: Ribonuclease_P; pfam00825 936155005414 HMMPfam hit to PF00825, Ribonuclease_P, score 5.3e-20 936155005415 PS00648 Bacterial ribonuclease P protein component signature 936155005416 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 936155005417 HMMPfam hit to PF00468, Ribosomal_L34, score 6.5e-18 936155005418 PS00784 Ribosomal protein L34 signature 936155005419 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 936155005420 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 936155005421 HMMPfam hit to PF02472, ExbD, score 5.5e-31 936155005422 1 probable transmembrane helix predicted for Hfelis12170 by TMHMM2.0 at aa 10-32 936155005423 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 936155005424 HMMPfam hit to PF01618, MotA_ExbB, score 3.7e-60 936155005425 3 probable transmembrane helices predicted for Hfelis12180 by TMHMM2.0 at aa 15-37, 58-80 and 100-122 936155005426 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 936155005427 SmpB-tmRNA interface; other site 936155005428 HMMPfam hit to PF01668, SmpB, score 2.9e-40 936155005429 PS01317 Protein smpB signature 936155005430 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 936155005431 HMMPfam hit to PF00288, GHMP_kinases_N, score 7.1e-12 936155005432 carbon storage regulator; Provisional; Region: PRK00568 936155005433 HMMPfam hit to PF02599, CsrA, score 7.3e-20 936155005434 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 936155005435 active site 936155005436 HMMPfam hit to PF00160, Pro_isomerase, score 1.2e-50 936155005437 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature 936155005438 antiviral radical SAM protein viperin; Region: viperin; TIGR04278 936155005439 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005440 LabA_like proteins; Region: LabA_like; cd06167 936155005441 putative metal binding site [ion binding]; other site 936155005442 Uncharacterized conserved protein [Function unknown]; Region: COG1479 936155005443 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155005444 HMMPfam hit to PF03235, DUF262, score 4.1e-36 936155005445 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155005446 Uncharacterized conserved protein [Function unknown]; Region: COG1479 936155005447 HMMPfam hit to PF03235, DUF262, score 2.2e-10 936155005448 DNA repair protein RadA; Provisional; Region: PRK11823 936155005449 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 936155005450 Walker A motif; other site 936155005451 ATP binding site [chemical binding]; other site 936155005452 Walker B motif; other site 936155005453 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 936155005454 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005455 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 936155005456 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936155005457 HMMPfam hit to PF00448, SRP54, score 2.5e-103 936155005458 PS00300 SRP54-type proteins GTP-binding domain signature 936155005459 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005461 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 936155005462 FMN binding site [chemical binding]; other site 936155005463 dimer interface [polypeptide binding]; other site 936155005464 HMMPfam hit to PF00881, Nitroreductase, score 5.8e-29 936155005465 PS00070 Aldehyde dehydrogenases cysteine active site 936155005466 S-adenosylmethionine synthetase; Validated; Region: PRK05250 936155005467 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 936155005468 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 936155005469 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 936155005470 HMMPfam hit to PF02773, S-AdoMet_synt_C, score 8.3e-84 936155005471 PS00377 S-adenosylmethionine synthetase signature 2 936155005472 HMMPfam hit to PF02772, S-AdoMet_synt_M, score 5.9e-72 936155005473 PS00376 S-adenosylmethionine synthetase signature 1 936155005474 HMMPfam hit to PF00438, S-AdoMet_synt_N, score 7.4e-47 936155005475 elongation factor Ts; Provisional; Region: tsf; PRK09377 936155005476 UBA/TS-N domain; Region: UBA; pfam00627 936155005477 Elongation factor TS; Region: EF_TS; pfam00889 936155005478 Elongation factor TS; Region: EF_TS; pfam00889 936155005479 HMMPfam hit to PF00889, EF_TS, score 3.6e-91 936155005480 PS01127 Elongation factor Ts signature 2 936155005481 HMMPfam hit to PF00627, UBA, score 3.7e-15 936155005482 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 936155005483 rRNA interaction site [nucleotide binding]; other site 936155005484 S8 interaction site; other site 936155005485 putative laminin-1 binding site; other site 936155005486 HMMPfam hit to PF00318, Ribosomal_S2, score 5.1e-98 936155005487 PS00963 Ribosomal protein S2 signature 2 936155005488 PS00962 Ribosomal protein S2 signature 1 936155005489 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 936155005490 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 936155005491 Substrate binding site; other site 936155005492 Mg++ binding site; other site 936155005493 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 936155005494 active site 936155005495 substrate binding site [chemical binding]; other site 936155005496 CoA binding site [chemical binding]; other site 936155005497 HMMPfam hit to PF01128, IspD, score 1e-05 936155005498 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 936155005499 4 probable transmembrane helices predicted for Hfelis12390 by TMHMM2.0 at aa 5-22, 42-64, 190-212 and 222-241 936155005500 HMMPfam hit to PF00813, FliP, score 2.4e-132 936155005501 PS01060 Flagella transport protein fliP family signature 1 936155005502 4 probable transmembrane helices predicted for Hfelis12400 by TMHMM2.0 at aa 2-24, 37-59, 66-88 and 108-130 936155005503 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155005504 HMMPfam hit to PF01856, HP_OMP, score 1.4e-38 936155005505 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 936155005506 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936155005507 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 936155005508 HMMPfam hit to PF06429, DUF1078, score 0.0046 936155005509 HMMPfam hit to PF00460, Flg_bb_rod, score 1.6e-05 936155005510 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936155005511 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 936155005512 5 probable transmembrane helices predicted for Hfelis12430 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 128-150 and 160-182 936155005513 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005514 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 936155005515 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 936155005516 G1 box; other site 936155005517 GTP/Mg2+ binding site [chemical binding]; other site 936155005518 G2 box; other site 936155005519 Switch I region; other site 936155005520 G3 box; other site 936155005521 Switch II region; other site 936155005522 G4 box; other site 936155005523 G5 box; other site 936155005524 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 936155005525 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 936155005526 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 936155005527 HMMPfam hit to PF00009, GTP_EFTU, score 2.8e-36 936155005528 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005529 PS00301 GTP-binding elongation factors signature 936155005530 HMMPfam hit to PF03144, GTP_EFTU_D2, score 2.1e-07 936155005531 HMMPfam hit to PF09107, SelB-wing_3, score 1.3e-06 936155005532 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 936155005533 HMMPfam hit to PF01266, DAO, score 1.8e-54 936155005534 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2 936155005535 glycerol kinase; Provisional; Region: glpK; PRK00047 936155005536 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 936155005537 N- and C-terminal domain interface [polypeptide binding]; other site 936155005538 active site 936155005539 MgATP binding site [chemical binding]; other site 936155005540 catalytic site [active] 936155005541 metal binding site [ion binding]; metal-binding site 936155005542 glycerol binding site [chemical binding]; other site 936155005543 homotetramer interface [polypeptide binding]; other site 936155005544 homodimer interface [polypeptide binding]; other site 936155005545 FBP binding site [chemical binding]; other site 936155005546 protein IIAGlc interface [polypeptide binding]; other site 936155005547 HMMPfam hit to PF00370, FGGY_N, score 2.3e-109 936155005548 PS00933 FGGY family of carbohydrate kinases signature 1 936155005549 HMMPfam hit to PF02782, FGGY_C, score 5e-76 936155005550 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005551 PS00445 FGGY family of carbohydrate kinases signature 2 936155005552 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 936155005553 amphipathic channel; other site 936155005554 Asn-Pro-Ala signature motifs; other site 936155005555 6 probable transmembrane helices predicted for Hfelis12480 by TMHMM2.0 at aa 5-27, 42-64, 85-107, 141-163, 170-192 and 224-246 936155005556 HMMPfam hit to PF00230, MIP, score 1.7e-21 936155005557 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005558 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 936155005559 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 936155005560 Na binding site [ion binding]; other site 936155005561 12 probable transmembrane helices predicted for Hfelis12500 by TMHMM2.0 at aa 7-26, 66-88, 124-146, 161-180, 192-214, 229-251, 272-294, 309-331, 364-386, 396-418, 423-440 and 450-472 936155005562 HMMPfam hit to PF00474, SSF, score 1e-120 936155005563 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005564 Proline dehydrogenase; Region: Pro_dh; cl03282 936155005565 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 936155005566 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936155005567 Glutamate binding site [chemical binding]; other site 936155005568 NAD binding site [chemical binding]; other site 936155005569 catalytic residues [active] 936155005570 HMMPfam hit to PF00171, Aldedh, score 2.7e-107 936155005571 PS00070 Aldehyde dehydrogenases cysteine active site 936155005572 PS00687 Aldehyde dehydrogenases glutamic acid active site 936155005573 HMMPfam hit to PF01619, Pro_dh, score 6.1e-96 936155005574 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936155005575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936155005576 non-specific DNA binding site [nucleotide binding]; other site 936155005577 salt bridge; other site 936155005578 sequence-specific DNA binding site [nucleotide binding]; other site 936155005579 Predicted transcriptional regulator [Transcription]; Region: COG2932 936155005580 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936155005581 Catalytic site [active] 936155005582 HMMPfam hit to PF01381, HTH_3, score 2.5e-18 936155005583 Predicted helix-turn-helix motif with score 2013.000, SD 6.04 at aa 15-36, sequence LTQEELALKCGVSLQSIKRYES 936155005584 HMMPfam hit to PF00717, Peptidase_S24, score 2.9e-10 936155005585 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 936155005586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936155005587 active site 936155005588 phosphorylation site [posttranslational modification] 936155005589 intermolecular recognition site; other site 936155005590 dimerization interface [polypeptide binding]; other site 936155005591 HMMPfam hit to PF00072, Response_reg, score 1.8e-38 936155005592 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 936155005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 936155005594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155005595 S-adenosylmethionine binding site [chemical binding]; other site 936155005596 HMMPfam hit to PF06325, PrmA, score 1.5e-23 936155005597 FtsH Extracellular; Region: FtsH_ext; pfam06480 936155005598 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 936155005599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155005600 Walker A motif; other site 936155005601 ATP binding site [chemical binding]; other site 936155005602 Walker B motif; other site 936155005603 arginine finger; other site 936155005604 Peptidase family M41; Region: Peptidase_M41; pfam01434 936155005605 2 probable transmembrane helices predicted for Hfelis12570 by TMHMM2.0 at aa 20-39 and 123-145 936155005606 HMMPfam hit to PF06480, FtsH_ext, score 6.4e-30 936155005607 HMMPfam hit to PF00004, AAA, score 4.3e-96 936155005608 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005609 PS00674 AAA-protein family signature 936155005610 HMMPfam hit to PF01434, Peptidase_M41, score 4e-113 936155005611 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 936155005612 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 936155005613 8 probable transmembrane helices predicted for Hfelis12580 by TMHMM2.0 at aa 5-27, 32-54, 67-89, 93-110, 123-142, 147-169, 182-199 and 204-223 936155005614 HMMPfam hit to PF01066, CDP-OH_P_transf, score 1.8e-28 936155005615 PS00379 CDP-alcohol phosphatidyltransferases signature 936155005616 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936155005617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936155005618 metal-binding site [ion binding] 936155005619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936155005620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936155005621 motif II; other site 936155005622 HMMPfam hit to PF00403, HMA, score 9.1e-15 936155005623 PS01047 Heavy-metal-associated domain 936155005624 8 probable transmembrane helices predicted for Hfelis12590 by TMHMM2.0 at aa 89-111, 121-143, 156-178, 182-200, 337-359, 369-391, 667-686 and 690-712 936155005625 HMMPfam hit to PF00122, E1-E2_ATPase, score 2.4e-70 936155005626 HMMPfam hit to PF00702, Hydrolase, score 8.8e-41 936155005627 PS00154 E1-E2 ATPases phosphorylation site 936155005628 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936155005629 metal-binding site [ion binding] 936155005630 HMMPfam hit to PF00403, HMA, score 2.7e-09 936155005631 PS01047 Heavy-metal-associated domain 936155005632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936155005633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936155005634 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 936155005635 Walker A/P-loop; other site 936155005636 ATP binding site [chemical binding]; other site 936155005637 Q-loop/lid; other site 936155005638 ABC transporter signature motif; other site 936155005639 Walker B; other site 936155005640 D-loop; other site 936155005641 H-loop/switch region; other site 936155005642 HMMPfam hit to PF00664, ABC_membrane, score 6.8e-41 936155005643 5 probable transmembrane helices predicted for Hfelis12610 by TMHMM2.0 at aa 20-39, 54-76, 145-167, 242-264 and 271-290 936155005644 HMMPfam hit to PF00005, ABC_tran, score 3.8e-55 936155005645 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005646 PS00211 ABC transporters family signature 936155005647 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005648 HMMPfam hit to PF02743, Cache_1, score 6.9e-05 936155005649 4 probable transmembrane helices predicted for Hfelis12630 by TMHMM2.0 at aa 156-175, 195-217, 238-257 and 267-289 936155005650 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936155005651 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936155005652 transmembrane helices; other site 936155005653 HMMPfam hit to PF00939, Na_sulph_symp, score 8.5e-204 936155005654 13 probable transmembrane helices predicted for Hfelis12640 by TMHMM2.0 at aa 5-22, 32-49, 54-71, 86-108, 182-204, 224-246, 277-294, 298-320, 327-346, 366-388, 395-412, 422-444 and 456-478 936155005655 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 936155005656 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 936155005657 metal-binding site 936155005658 HMMPfam hit to PF00535, Glycos_transf_2, score 1.9e-28 936155005659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155005660 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936155005661 HMMPfam hit to PF00534, Glycos_transf_1, score 1e-26 936155005662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155005663 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 936155005664 HMMPfam hit to PF00534, Glycos_transf_1, score 2.2e-20 936155005665 Predicted helix-turn-helix motif with score 979.000, SD 2.52 at aa 172-193, sequence MKQRAYAKIPHLCIVGVSSWIS 936155005666 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 936155005667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936155005668 active site 936155005669 motif I; other site 936155005670 motif II; other site 936155005671 HMMPfam hit to PF00702, Hydrolase, score 1e-11 936155005672 VRR-NUC domain; Region: VRR_NUC; cl17748 936155005673 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 936155005674 HMMPfam hit to PF08774, VRR_NUC, score 0.00022 936155005675 Predicted helix-turn-helix motif with score 1028.000, SD 2.69 at aa 329-350, sequence KKLTSTADIAGRLFNTLTKWLN 936155005676 HMMPfam hit to PF02384, N6_Mtase, score 7.3e-07 936155005677 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005678 HMMPfam hit to PF07674, DUF1603, score 8.2e-13 936155005679 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005680 HMMPfam hit to PF07674, DUF1603, score 3.8e-20 936155005681 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005682 HMMPfam hit to PF07674, DUF1603, score 7.4e-15 936155005683 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005684 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005685 HMMPfam hit to PF07674, DUF1603, score 7.1e-16 936155005686 1 probable transmembrane helix predicted for Hfelis12740 by TMHMM2.0 at aa 5-27 936155005687 Predicted helix-turn-helix motif with score 1205.000, SD 3.29 at aa 264-285, sequence AYYKQVQKILGLSLQDIQRWKN 936155005688 1 probable transmembrane helix predicted for Hfelis12750 by TMHMM2.0 at aa 9-31 936155005689 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 936155005690 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 936155005691 NADP binding site [chemical binding]; other site 936155005692 active site 936155005693 putative substrate binding site [chemical binding]; other site 936155005694 HMMPfam hit to PF01370, Epimerase, score 2e-83 936155005695 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 936155005696 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 936155005697 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 936155005698 HMMPfam hit to PF03382, DUF285, score 2.5e-64 936155005699 HMMPfam hit to PF03382, DUF285, score 1.7e-60 936155005700 1 probable transmembrane helix predicted for Hfelis12780 by TMHMM2.0 at aa 5-27 936155005701 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005702 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 936155005703 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 936155005704 nickel binding site [ion binding]; other site 936155005705 putative substrate-binding site; other site 936155005706 HMMPfam hit to PF01750, HycI, score 1.3e-22 936155005707 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 936155005708 HMMPfam hit to PF01292, Ni_hydr_CYTB, score 8e-30 936155005709 4 probable transmembrane helices predicted for Hfelis12810 by TMHMM2.0 at aa 22-44, 64-86, 131-153 and 186-208 936155005710 PS00882 Nickel-dependent hydrogenases b-type cytochrome subunit signature 1 936155005711 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 936155005712 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 936155005713 HMMPfam hit to PF00374, NiFeSe_Hases, score 2.7e-287 936155005714 PS00508 Nickel-dependent hydrogenases large subunit signature 2 936155005715 PS00507 Nickel-dependent hydrogenases large subunit signature 1 936155005716 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 936155005717 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 936155005718 HMMPfam hit to PF01058, Oxidored_q6, score 5.3e-07 936155005719 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155005720 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155005721 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.8e-21 936155005722 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155005723 DNA methylase; Region: N6_N4_Mtase; pfam01555 936155005724 HMMPfam hit to PF01555, N6_N4_Mtase, score 3e-56 936155005725 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 936155005726 HMMPfam hit to PF02945, Endonuclease_7, score 3.5e-29 936155005727 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 936155005728 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936155005729 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155005730 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 936155005731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936155005732 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155005733 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 936155005734 IMP binding site; other site 936155005735 dimer interface [polypeptide binding]; other site 936155005736 interdomain contacts; other site 936155005737 partial ornithine binding site; other site 936155005738 HMMPfam hit to PF02142, MGS, score 1.4e-22 936155005739 HMMPfam hit to PF02786, CPSase_L_D2, score 2.8e-12 936155005740 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 936155005741 HMMPfam hit to PF00289, CPSase_L_chain, score 6e-11 936155005742 HMMPfam hit to PF02787, CPSase_L_D3, score 8.2e-40 936155005743 HMMPfam hit to PF02786, CPSase_L_D2, score 1.8e-104 936155005744 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 936155005745 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 936155005746 HMMPfam hit to PF00289, CPSase_L_chain, score 2e-36 936155005747 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005748 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 936155005749 Methyltransferase domain; Region: Methyltransf_31; pfam13847 936155005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155005751 S-adenosylmethionine binding site [chemical binding]; other site 936155005752 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 936155005753 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005754 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005755 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 936155005756 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155005757 HMMPfam hit to PF01420, Methylase_S, score 1.9e-20 936155005758 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005759 HMMPfam hit to PF01420, Methylase_S, score 8.2e-10 936155005760 HMMPfam hit to PF01420, Methylase_S, score 1.5e-22 936155005761 HMMPfam hit to PF02384, N6_Mtase, score 3.9e-09 936155005762 PS00092 N-6 Adenine-specific DNA methylases signature 936155005763 PS00290 Immunoglobulins and major histocompatibility complex proteins signature 936155005764 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 936155005765 HMMPfam hit to PF06518, DUF1104, score 7.5e-31 936155005766 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 936155005767 HMMPfam hit to PF07510, DUF1524, score 2e-05 936155005768 Uncharacterized conserved protein [Function unknown]; Region: COG1479 936155005769 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155005770 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155005771 HMMPfam hit to PF03235, DUF262, score 2.4e-49 936155005772 alanine racemase; Reviewed; Region: alr; PRK00053 936155005773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 936155005774 active site 936155005775 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936155005776 dimer interface [polypeptide binding]; other site 936155005777 substrate binding site [chemical binding]; other site 936155005778 catalytic residues [active] 936155005779 HMMPfam hit to PF00842, Ala_racemase_C, score 3.5e-55 936155005780 HMMPfam hit to PF01168, Ala_racemase_N, score 2.3e-74 936155005781 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936155005782 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 936155005783 HMMPfam hit to PF01235, Na_Ala_symp, score 3.7e-92 936155005784 11 probable transmembrane helices predicted for Hfelis12940 by TMHMM2.0 at aa 15-37, 68-90, 95-117, 138-160, 180-202, 209-231, 246-268, 305-327, 347-369, 382-399 and 409-431 936155005785 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 936155005786 HMMPfam hit to PF01266, DAO, score 8.5e-71 936155005787 1 probable transmembrane helix predicted for Hfelis12950 by TMHMM2.0 at aa 5-22 936155005788 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155005789 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 936155005790 homotrimer interaction site [polypeptide binding]; other site 936155005791 putative active site [active] 936155005792 HMMPfam hit to PF01042, Ribonuc_L-PSP, score 7.9e-64 936155005793 PS01094 Uncharacterized protein family UPF0076 signature 936155005794 Sporulation related domain; Region: SPOR; pfam05036 936155005795 HMMPfam hit to PF05036, SPOR, score 0.17 936155005796 1 probable transmembrane helix predicted for Hfelis12970 by TMHMM2.0 at aa 33-52 936155005797 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 936155005798 HMMPfam hit to PF01896, DNA_primase_S, score 0.00062 936155005799 HMMPfam hit to PF08966, DUF1882, score 4.8e-47 936155005800 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 936155005801 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 936155005802 dimer interface [polypeptide binding]; other site 936155005803 active site 936155005804 glycine-pyridoxal phosphate binding site [chemical binding]; other site 936155005805 folate binding site [chemical binding]; other site 936155005806 HMMPfam hit to PF00464, SHMT, score 1.1e-236 936155005807 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site 936155005808 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 936155005809 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 936155005810 dimer interface [polypeptide binding]; other site 936155005811 putative anticodon binding site; other site 936155005812 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 936155005813 motif 1; other site 936155005814 active site 936155005815 motif 2; other site 936155005816 motif 3; other site 936155005817 HMMPfam hit to PF00152, tRNA-synt_2, score 2.9e-112 936155005818 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155005819 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 936155005820 HMMPfam hit to PF01336, tRNA_anti, score 1.1e-16 936155005821 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 936155005822 Colicin V production protein; Region: Colicin_V; pfam02674 936155005823 HMMPfam hit to PF02674, Colicin_V, score 2.1e-21 936155005824 4 probable transmembrane helices predicted for Hfelis13010 by TMHMM2.0 at aa 7-24, 28-45, 66-88 and 103-125 936155005825 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 936155005826 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 936155005827 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 936155005828 active site 936155005829 catalytic triad [active] 936155005830 5 probable transmembrane helices predicted for Hfelis13020 by TMHMM2.0 at aa 13-35, 39-61, 66-85, 90-112 and 119-141 936155005831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 936155005832 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936155005833 Walker A/P-loop; other site 936155005834 ATP binding site [chemical binding]; other site 936155005835 Q-loop/lid; other site 936155005836 ABC transporter signature motif; other site 936155005837 Walker B; other site 936155005838 D-loop; other site 936155005839 H-loop/switch region; other site 936155005840 HMMPfam hit to PF00005, ABC_tran, score 2.9e-48 936155005841 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005842 PS00211 ABC transporters family signature 936155005843 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155005844 HMMPfam hit to PF02521, HP_OMP_2, score 2.5e-178 936155005845 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 936155005846 HMMPfam hit to PF01196, Ribosomal_L17, score 6e-45 936155005847 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 936155005848 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 936155005849 alphaNTD homodimer interface [polypeptide binding]; other site 936155005850 alphaNTD - beta interaction site [polypeptide binding]; other site 936155005851 alphaNTD - beta' interaction site [polypeptide binding]; other site 936155005852 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 936155005853 HMMPfam hit to PF03118, RNA_pol_A_CTD, score 1.9e-21 936155005854 HMMPfam hit to PF01193, RNA_pol_L, score 1.3e-13 936155005855 HMMPfam hit to PF01000, RNA_pol_A_bac, score 8.4e-25 936155005856 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 936155005857 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 936155005858 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936155005859 RNA binding surface [nucleotide binding]; other site 936155005860 HMMPfam hit to PF01479, S4, score 7e-19 936155005861 PS00632 Ribosomal protein S4 signature 936155005862 HMMPfam hit to PF00163, Ribosomal_S4, score 3.7e-24 936155005863 Predicted helix-turn-helix motif with score 1061.000, SD 2.80 at aa 58-79, sequence REKQKAKAMYGISEKQFRSIFR 936155005864 30S ribosomal protein S11; Validated; Region: PRK05309 936155005865 HMMPfam hit to PF00411, Ribosomal_S11, score 3.6e-58 936155005866 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 936155005867 30S ribosomal protein S13; Region: bact_S13; TIGR03631 936155005868 HMMPfam hit to PF00416, Ribosomal_S13, score 4.2e-52 936155005869 PS00646 Ribosomal protein S13 signature 936155005870 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 936155005871 HMMPfam hit to PF00444, Ribosomal_L36, score 2.3e-16 936155005872 PS00828 Ribosomal protein L36 signature 936155005873 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 936155005874 rRNA binding site [nucleotide binding]; other site 936155005875 predicted 30S ribosome binding site; other site 936155005876 HMMPfam hit to PF01176, eIF-1a, score 9e-31 936155005877 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 936155005878 active site 936155005879 HMMPfam hit to PF00557, Peptidase_M24, score 9.8e-54 936155005880 PS00680 Methionine aminopeptidase subfamily 1 signature 936155005881 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 936155005882 SecY translocase; Region: SecY; pfam00344 936155005883 HMMPfam hit to PF00344, SecY, score 3.9e-125 936155005884 10 probable transmembrane helices predicted for Hfelis13130 by TMHMM2.0 at aa 13-35, 61-83, 104-124, 139-161, 168-190, 200-222, 255-277, 297-319, 355-374 and 379-396 936155005885 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature 936155005886 PS00756 Protein secY signature 2 936155005887 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 936155005888 HMMPfam hit to PF01305, Ribosomal_L15, score 2.7e-49 936155005889 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 936155005890 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 936155005891 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 936155005892 HMMPfam hit to PF03719, Ribosomal_S5_C, score 2.7e-29 936155005893 HMMPfam hit to PF00333, Ribosomal_S5, score 3.7e-35 936155005894 PS00585 Ribosomal protein S5 signature 936155005895 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 936155005896 5S rRNA interface [nucleotide binding]; other site 936155005897 L27 interface [polypeptide binding]; other site 936155005898 23S rRNA interface [nucleotide binding]; other site 936155005899 L5 interface [polypeptide binding]; other site 936155005900 HMMPfam hit to PF00861, Ribosomal_L18p, score 5.9e-33 936155005901 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 936155005902 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 936155005903 HMMPfam hit to PF00347, Ribosomal_L6, score 1.1e-27 936155005904 PS00525 Ribosomal protein L6 signature 1 936155005905 HMMPfam hit to PF00347, Ribosomal_L6, score 0.0024 936155005906 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 936155005907 HMMPfam hit to PF00410, Ribosomal_S8, score 3.7e-47 936155005908 PS00053 Ribosomal protein S8 signature 936155005909 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 936155005910 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 936155005911 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 936155005912 HMMPfam hit to PF00673, Ribosomal_L5_C, score 3.4e-43 936155005913 HMMPfam hit to PF00281, Ribosomal_L5, score 3.6e-22 936155005914 PS00358 Ribosomal protein L5 signature 936155005915 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 936155005916 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 936155005917 RNA binding site [nucleotide binding]; other site 936155005918 HMMPfam hit to PF00467, KOW, score 7.6e-10 936155005919 PS01108 Ribosomal protein L24 signature 936155005920 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 936155005921 HMMPfam hit to PF00238, Ribosomal_L14, score 1.7e-75 936155005922 PS00049 Ribosomal protein L14 signature 936155005923 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 936155005924 HMMPfam hit to PF00366, Ribosomal_S17, score 4.4e-15 936155005925 PS00056 Ribosomal protein S17 signature 936155005926 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 936155005927 trigger factor interaction site; other site 936155005928 23S rRNA interface [nucleotide binding]; other site 936155005929 HMMPfam hit to PF00831, Ribosomal_L29, score 1.2e-18 936155005930 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 936155005931 23S rRNA interface [nucleotide binding]; other site 936155005932 5S rRNA interface [nucleotide binding]; other site 936155005933 putative antibiotic binding site [chemical binding]; other site 936155005934 L25 interface [polypeptide binding]; other site 936155005935 L27 interface [polypeptide binding]; other site 936155005936 HMMPfam hit to PF00252, Ribosomal_L16, score 3.3e-81 936155005937 PS00701 Ribosomal protein L16 signature 2 936155005938 PS00586 Ribosomal protein L16 signature 1 936155005939 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 936155005940 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 936155005941 G-X-X-G motif; other site 936155005942 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 936155005943 HMMPfam hit to PF00189, Ribosomal_S3_C, score 1.8e-48 936155005944 PS00548 Ribosomal protein S3 signature 936155005945 HMMPfam hit to PF07650, KH_2, score 7.7e-16 936155005946 HMMPfam hit to PF00417, Ribosomal_S3_N, score 3.2e-27 936155005947 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 936155005948 putative translocon binding site; other site 936155005949 protein-rRNA interface [nucleotide binding]; other site 936155005950 HMMPfam hit to PF00237, Ribosomal_L22, score 9e-21 936155005951 PS00464 Ribosomal protein L22 signature 936155005952 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 936155005953 HMMPfam hit to PF00203, Ribosomal_S19, score 1.2e-43 936155005954 PS00323 Ribosomal protein S19 signature 936155005955 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 936155005956 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 936155005957 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 936155005958 HMMPfam hit to PF03947, Ribosomal_L2_C, score 6.9e-82 936155005959 PS00467 Ribosomal protein L2 signature 936155005960 HMMPfam hit to PF00181, Ribosomal_L2, score 2.2e-44 936155005961 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 936155005962 HMMPfam hit to PF00276, Ribosomal_L23, score 8.4e-07 936155005963 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005964 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 936155005965 HMMPfam hit to PF00573, Ribosomal_L4, score 6.8e-58 936155005966 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 936155005967 HMMPfam hit to PF00297, Ribosomal_L3, score 2.1e-31 936155005968 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 936155005969 HMMPfam hit to PF00338, Ribosomal_S10, score 2e-41 936155005970 PS00361 Ribosomal protein S10 signature 936155005971 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 936155005972 PS00017 ATP/GTP-binding site motif A (P-loop) 936155005973 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 936155005974 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936155005975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936155005976 HMMPfam hit to PF04551, GcpE, score 4.8e-180 936155005977 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 936155005978 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 936155005979 putative trimer interface [polypeptide binding]; other site 936155005980 putative CoA binding site [chemical binding]; other site 936155005981 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155005982 Sel1-like repeats; Region: SEL1; smart00671 936155005983 Sel1-like repeats; Region: SEL1; smart00671 936155005984 Sel1-like repeats; Region: SEL1; smart00671 936155005985 Sel1-like repeats; Region: SEL1; smart00671 936155005986 HMMPfam hit to PF08238, Sel1, score 0.004 936155005987 HMMPfam hit to PF08238, Sel1, score 7.8e-07 936155005988 HMMPfam hit to PF08238, Sel1, score 2.1 936155005989 HMMPfam hit to PF08238, Sel1, score 1.4e-11 936155005990 HMMPfam hit to PF08238, Sel1, score 3.9e-07 936155005991 HMMPfam hit to PF08238, Sel1, score 2.2e-05 936155005992 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 936155005993 HMMPfam hit to PF02686, Glu-tRNAGln, score 8.2e-07 936155005994 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 936155005995 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 936155005996 putative substrate binding site [chemical binding]; other site 936155005997 putative ATP binding site [chemical binding]; other site 936155005998 HMMPfam hit to PF03853, YjeF_N, score 1.7e-46 936155005999 HMMPfam hit to PF01256, Carb_kinase, score 3.6e-46 936155006000 PS01050 Uncharacterized protein family UPF0031 signature 2 936155006001 replicative DNA helicase; Provisional; Region: PRK08506 936155006002 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 936155006003 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 936155006004 Walker A motif; other site 936155006005 ATP binding site [chemical binding]; other site 936155006006 Walker B motif; other site 936155006007 DNA binding loops [nucleotide binding] 936155006008 HMMPfam hit to PF00772, DnaB, score 4.6e-06 936155006009 HMMPfam hit to PF03796, DnaB_C, score 1.8e-104 936155006010 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006011 Competence protein; Region: Competence; cl00471 936155006012 9 probable transmembrane helices predicted for Hfelis13400 by TMHMM2.0 at aa 20-42, 181-203, 220-242, 252-274, 281-303, 313-335, 342-364, 384-403 and 410-427 936155006013 HMMPfam hit to PF03772, Competence, score 1.6e-19 936155006014 prenyltransferase; Reviewed; Region: ubiA; PRK12874 936155006015 UbiA prenyltransferase family; Region: UbiA; pfam01040 936155006016 8 probable transmembrane helices predicted for Hfelis13410 by TMHMM2.0 at aa 7-29, 44-66, 86-105, 109-131, 138-160, 164-186, 228-250 and 265-287 936155006017 HMMPfam hit to PF01040, UbiA, score 2e-61 936155006018 1 probable transmembrane helix predicted for Hfelis13430 by TMHMM2.0 at aa 10-29 936155006019 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 936155006020 HMMPfam hit to PF02666, PS_Dcarbxylase, score 1.1e-59 936155006021 quinolinate synthetase; Provisional; Region: PRK09375 936155006022 HMMPfam hit to PF02445, NadA, score 2.2e-154 936155006023 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 936155006024 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 936155006025 dimerization interface [polypeptide binding]; other site 936155006026 active site 936155006027 HMMPfam hit to PF02749, QRPTase_N, score 2.5e-23 936155006028 HMMPfam hit to PF01729, QRPTase_C, score 1.5e-87 936155006029 thiamine monophosphate kinase; Provisional; Region: PRK05731 936155006030 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 936155006031 ATP binding site [chemical binding]; other site 936155006032 dimerization interface [polypeptide binding]; other site 936155006033 HMMPfam hit to PF00586, AIRS, score 2.9e-21 936155006034 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 936155006035 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 936155006036 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 936155006037 protein binding site [polypeptide binding]; other site 936155006038 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 936155006039 Catalytic dyad [active] 936155006040 HMMPfam hit to PF00595, PDZ, score 1.7e-12 936155006041 HMMPfam hit to PF03572, Peptidase_S41, score 1.9e-72 936155006042 2 probable transmembrane helices predicted for Hfelis13490 by TMHMM2.0 at aa 247-269 and 276-298 936155006043 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 936155006044 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 936155006045 putative acyl-acceptor binding pocket; other site 936155006046 1 probable transmembrane helix predicted for Hfelis13500 by TMHMM2.0 at aa 5-27 936155006047 HMMPfam hit to PF01553, Acyltransferase, score 1.2e-19 936155006048 glutamine synthetase, type I; Region: GlnA; TIGR00653 936155006049 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 936155006050 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 936155006051 HMMPfam hit to PF03951, Gln-synt_N, score 6.8e-27 936155006052 HMMPfam hit to PF00120, Gln-synt_C, score 2.6e-150 936155006053 PS00181 Glutamine synthetase putative ATP-binding region signature 936155006054 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 936155006055 HMMPfam hit to PF05211, NLBH, score 7.8e-12 936155006056 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 936155006057 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 936155006058 urease subunit alpha; Provisional; Region: PRK13986 936155006059 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 936155006060 alpha-gamma subunit interface [polypeptide binding]; other site 936155006061 beta-gamma subunit interface [polypeptide binding]; other site 936155006062 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 936155006063 alpha-beta subunit interface [polypeptide binding]; other site 936155006064 HMMPfam hit to PF00547, Urease_gamma, score 1.9e-59 936155006065 HMMPfam hit to PF00699, Urease_beta, score 2.3e-37 936155006066 urease subunit beta; Provisional; Region: ureB; PRK13985 936155006067 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 936155006068 subunit interactions [polypeptide binding]; other site 936155006069 active site 936155006070 flap region; other site 936155006071 HMMPfam hit to PF00449, Urease_alpha, score 2.5e-82 936155006072 HMMPfam hit to PF01979, Amidohydro_1, score 3.9e-85 936155006073 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 936155006074 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936155006075 N-terminal plug; other site 936155006076 ligand-binding site [chemical binding]; other site 936155006077 HMMPfam hit to PF07715, Plug, score 3e-24 936155006078 HMMPfam hit to PF00593, TonB_dep_Rec, score 7.1e-18 936155006079 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 936155006080 2 probable transmembrane helices predicted for Hfelis13590 by TMHMM2.0 at aa 19-36 and 41-70 936155006081 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 936155006082 3 probable transmembrane helices predicted for Hfelis13600 by TMHMM2.0 at aa 29-46, 51-68 and 73-92 936155006083 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 936155006084 nucleotide binding site/active site [active] 936155006085 HIT family signature motif; other site 936155006086 catalytic residue [active] 936155006087 HMMPfam hit to PF01230, HIT, score 3.8e-35 936155006088 PS00892 HIT family signature 936155006089 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 936155006090 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936155006091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936155006092 catalytic residue [active] 936155006093 HMMPfam hit to PF00266, Aminotran_5, score 1.5e-18 936155006094 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006095 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 936155006096 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 936155006097 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 936155006098 8 probable transmembrane helices predicted for Hfelis13660 by TMHMM2.0 at aa 5-27, 42-64, 92-114, 124-146, 179-201, 216-238, 251-273 and 305-327 936155006099 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006100 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 936155006101 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 936155006102 homodimer interface [polypeptide binding]; other site 936155006103 substrate-cofactor binding pocket; other site 936155006104 catalytic residue [active] 936155006105 HMMPfam hit to PF01063, Aminotran_4, score 9e-30 936155006106 PS00770 Aminotransferases class-IV signature 936155006107 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 936155006108 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 936155006109 Ligand Binding Site [chemical binding]; other site 936155006110 HMMPfam hit to PF02677, DUF208, score 1.8e-91 936155006111 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 936155006112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936155006113 Mg2+ binding site [ion binding]; other site 936155006114 G-X-G motif; other site 936155006115 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 936155006116 anchoring element; other site 936155006117 dimer interface [polypeptide binding]; other site 936155006118 ATP binding site [chemical binding]; other site 936155006119 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 936155006120 active site 936155006121 putative metal-binding site [ion binding]; other site 936155006122 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 936155006123 HMMPfam hit to PF00986, DNA_gyraseB_C, score 2.4e-38 936155006124 HMMPfam hit to PF01751, Toprim, score 9.7e-10 936155006125 PS00177 DNA topoisomerase II signature 936155006126 HMMPfam hit to PF00204, DNA_gyraseB, score 4.2e-71 936155006127 HMMPfam hit to PF02518, HATPase_c, score 3.1e-30 936155006128 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 936155006129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155006130 Walker A motif; other site 936155006131 ATP binding site [chemical binding]; other site 936155006132 Walker B motif; other site 936155006133 arginine finger; other site 936155006134 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 936155006135 DnaA box-binding interface [nucleotide binding]; other site 936155006136 HMMPfam hit to PF08299, Bac_DnaA_C, score 7.8e-06 936155006137 HMMPfam hit to PF00308, Bac_DnaA, score 3.3e-105 936155006138 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006139 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936155006140 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 936155006141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936155006142 Soluble P-type ATPase [General function prediction only]; Region: COG4087 936155006143 6 probable transmembrane helices predicted for Hfelis13720 by TMHMM2.0 at aa 75-97, 102-124, 302-324, 339-361, 631-653 and 657-676 936155006144 HMMPfam hit to PF00702, Hydrolase, score 7e-17 936155006145 PS01229 Hypothetical cof family signature 2 936155006146 HMMPfam hit to PF00122, E1-E2_ATPase, score 1.6e-67 936155006147 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 936155006148 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 936155006149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155006150 Walker A motif; other site 936155006151 ATP binding site [chemical binding]; other site 936155006152 Walker B motif; other site 936155006153 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 936155006154 HMMPfam hit to PF01078, Mg_chelatase, score 1.3e-107 936155006155 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006156 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 936155006157 active site 936155006158 catalytic residues [active] 936155006159 metal binding site [ion binding]; metal-binding site 936155006160 HMMPfam hit to PF01327, Pep_deformylase, score 4.3e-52 936155006161 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 936155006162 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 936155006163 oligomer interface [polypeptide binding]; other site 936155006164 active site residues [active] 936155006165 HMMPfam hit to PF00574, CLP_protease, score 1.4e-130 936155006166 PS00382 Endopeptidase Clp histidine active site 936155006167 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006168 PS00381 Endopeptidase Clp serine active site 936155006169 trigger factor; Provisional; Region: tig; PRK01490 936155006170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936155006171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 936155006172 HMMPfam hit to PF05698, Trigger_C, score 2.4e-27 936155006173 HMMPfam hit to PF00254, FKBP_C, score 3.9e-19 936155006174 HMMPfam hit to PF05697, Trigger_N, score 1.7e-27 936155006175 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 936155006176 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 936155006177 Walker A motif/ATP binding site; other site 936155006178 Walker B motif; other site 936155006179 HMMPfam hit to PF00006, ATP-synt_ab, score 2e-114 936155006180 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006181 PS00152 ATP synthase alpha and beta subunits signature 936155006182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936155006183 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 936155006184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936155006185 catalytic residue [active] 936155006186 HMMPfam hit to PF00266, Aminotran_5, score 1e-104 936155006187 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site 936155006188 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006189 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 936155006190 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 936155006191 trimerization site [polypeptide binding]; other site 936155006192 active site 936155006193 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936155006194 NifU-like domain; Region: NifU; cl00484 936155006195 HMMPfam hit to PF01592, NifU_N, score 8.8e-67 936155006196 HMMPfam hit to PF04324, Fer2_BFD, score 1.9e-12 936155006197 HMMPfam hit to PF01106, NifU, score 9.1e-10 936155006198 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 936155006199 HMMPfam hit to PF05211, NLBH, score 7.7e-71 936155006200 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936155006201 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155006202 dimer interface [polypeptide binding]; other site 936155006203 putative CheW interface [polypeptide binding]; other site 936155006204 2 probable transmembrane helices predicted for Hfelis13810 by TMHMM2.0 at aa 10-32 and 191-213 936155006205 HMMPfam hit to PF00015, MCPsignal, score 2.4e-40 936155006206 Dehydroquinase class II; Region: DHquinase_II; pfam01220 936155006207 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 936155006208 trimer interface [polypeptide binding]; other site 936155006209 active site 936155006210 dimer interface [polypeptide binding]; other site 936155006211 HMMPfam hit to PF01220, DHquinase_II, score 5.6e-92 936155006212 PS01029 Dehydroquinase class II signature 936155006213 1 probable transmembrane helix predicted for Hfelis13820 by TMHMM2.0 at aa 117-139 936155006214 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 936155006215 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 936155006216 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 936155006217 active site 936155006218 HMMPfam hit to PF01321, Creatinase_N, score 0.00015 936155006219 HMMPfam hit to PF00557, Peptidase_M24, score 4.5e-46 936155006220 PS00491 Aminopeptidase P and proline dipeptidase signature 936155006221 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 936155006222 catalytic center binding site [active] 936155006223 ATP binding site [chemical binding]; other site 936155006224 HMMPfam hit to PF01288, HPPK, score 6.5e-37 936155006225 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature 936155006226 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 936155006227 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936155006228 HMMPfam hit to PF00448, SRP54, score 6.5e-51 936155006229 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006230 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 936155006231 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 936155006232 P-loop; other site 936155006233 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 936155006234 HMMPfam hit to PF01656, CbiA, score 4.3e-28 936155006235 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006236 2 probable transmembrane helices predicted for Hfelis13870 by TMHMM2.0 at aa 5-24 and 37-59 936155006237 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 936155006238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936155006239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936155006240 DNA binding residues [nucleotide binding] 936155006241 HMMPfam hit to PF04542, Sigma70_r2, score 2.2e-11 936155006242 HMMPfam hit to PF04545, Sigma70_r4, score 1.3e-14 936155006243 Predicted helix-turn-helix motif with score 2077.000, SD 6.26 at aa 196-217, sequence LNLSEIREILGVTESRISQIIK 936155006244 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 936155006245 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 936155006246 HMMPfam hit to PF02154, FliM, score 1.9e-115 936155006247 HMMPfam hit to PF01052, SpoA, score 1.7e-17 936155006248 flagellar motor switch protein FliY; Validated; Region: PRK08432 936155006249 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 936155006250 phosphoinositide binding site [chemical binding]; other site 936155006251 flagellar motor switch protein FliN; Region: fliN; TIGR02480 936155006252 HMMPfam hit to PF01052, SpoA, score 9.7e-25 936155006253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 936155006254 Predicted dehydrogenase [General function prediction only]; Region: COG0579 936155006255 HMMPfam hit to PF01266, DAO, score 2.7e-66 936155006256 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 936155006257 substrate binding pocket [chemical binding]; other site 936155006258 active site 936155006259 iron coordination sites [ion binding]; other site 936155006260 HMMPfam hit to PF08943, CsiD, score 1e-182 936155006261 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.7e-15 936155006262 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 936155006263 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936155006264 active site 936155006265 HIGH motif; other site 936155006266 nucleotide binding site [chemical binding]; other site 936155006267 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936155006268 active site 936155006269 KMSKS motif; other site 936155006270 HMMPfam hit to PF00749, tRNA-synt_1c, score 4.3e-59 936155006271 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155006272 YGGT family; Region: YGGT; pfam02325 936155006273 2 probable transmembrane helices predicted for Hfelis13990 by TMHMM2.0 at aa 7-29 and 71-93 936155006274 HMMPfam hit to PF02325, YGGT, score 6.9e-22 936155006275 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 936155006276 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936155006277 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936155006278 catalytic residue [active] 936155006279 HMMPfam hit to PF01464, SLT, score 2.2e-21 936155006280 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936155006281 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936155006282 active site 936155006283 tetramer interface; other site 936155006284 HMMPfam hit to PF00483, NTP_transferase, score 4.2e-19 936155006285 1 probable transmembrane helix predicted for Hfelis14020 by TMHMM2.0 at aa 7-29 936155006286 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 936155006287 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 936155006288 hinge; other site 936155006289 active site 936155006290 HMMPfam hit to PF00275, EPSP_synthase, score 6.6e-104 936155006291 PS00028 Zinc finger, C2H2 type, domain 936155006292 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006293 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 936155006294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936155006295 putative substrate translocation pore; other site 936155006296 12 probable transmembrane helices predicted for Hfelis14040 by TMHMM2.0 at aa 13-35, 50-72, 85-102, 112-134, 155-177, 182-201, 229-251, 266-288, 297-319, 324-346, 359-381 and 391-410 936155006297 HMMPfam hit to PF00083, Sugar_tr, score 1.6e-18 936155006298 PS00217 Sugar transport proteins signature 2 936155006299 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 936155006300 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 936155006301 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 936155006302 trimer interface [polypeptide binding]; other site 936155006303 active site 936155006304 UDP-GlcNAc binding site [chemical binding]; other site 936155006305 lipid binding site [chemical binding]; lipid-binding site 936155006306 HMMPfam hit to PF00132, Hexapep, score 22 936155006307 HMMPfam hit to PF00132, Hexapep, score 8.6 936155006308 HMMPfam hit to PF00132, Hexapep, score 39 936155006309 HMMPfam hit to PF00132, Hexapep, score 1.7 936155006310 HMMPfam hit to PF00132, Hexapep, score 0.0085 936155006311 HMMPfam hit to PF00132, Hexapep, score 0.00076 936155006312 HMMPfam hit to PF00132, Hexapep, score 0.085 936155006313 PS00101 Hexapeptide-repeat containing-transferases signature 936155006314 HMMPfam hit to PF00132, Hexapep, score 3.2 936155006315 HMMPfam hit to PF04613, LpxD, score 5.5e-29 936155006316 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 936155006317 triosephosphate isomerase; Provisional; Region: PRK14565 936155006318 substrate binding site [chemical binding]; other site 936155006319 dimer interface [polypeptide binding]; other site 936155006320 catalytic triad [active] 936155006321 HMMPfam hit to PF00121, TIM, score 5.7e-64 936155006322 PS00171 Triosephosphate isomerase active site 936155006323 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 936155006324 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 936155006325 Iron-sulfur protein interface; other site 936155006326 proximal heme binding site [chemical binding]; other site 936155006327 distal heme binding site [chemical binding]; other site 936155006328 dimer interface [polypeptide binding]; other site 936155006329 HMMPfam hit to PF02967, Fum_red_TM, score 9.1e-149 936155006330 5 probable transmembrane helices predicted for Hfelis14070 by TMHMM2.0 at aa 32-54, 75-97, 125-147, 168-190 and 210-228 936155006331 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 936155006332 L-aspartate oxidase; Provisional; Region: PRK06175 936155006333 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936155006334 HMMPfam hit to PF00890, FAD_binding_2, score 3.5e-156 936155006335 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site 936155006336 HMMPfam hit to PF02910, Succ_DH_flav_C, score 1.8e-58 936155006337 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 936155006338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936155006339 catalytic loop [active] 936155006340 iron binding site [ion binding]; other site 936155006341 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 936155006342 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155006343 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006344 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 936155006345 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 936155006346 putative active site [active] 936155006347 catalytic site [active] 936155006348 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 936155006349 putative active site [active] 936155006350 catalytic site [active] 936155006351 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006352 HMMPfam hit to PF00614, PLDc, score 0.066 936155006353 HMMPfam hit to PF00614, PLDc, score 0.00053 936155006354 PS00225 Crystallins beta and gamma 'Greek key' motif signature 936155006355 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 936155006356 MraW methylase family; Region: Methyltransf_5; cl17771 936155006357 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 936155006358 HMMPfam hit to PF01795, Methyltransf_5, score 4e-99 936155006359 1 probable transmembrane helix predicted for Hfelis14130 by TMHMM2.0 at aa 43-65 936155006360 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 936155006361 substrate binding site [chemical binding]; other site 936155006362 catalytic residues [active] 936155006363 HMMPfam hit to PF02884, Lyase_8_C, score 3.4e-05 936155006364 HMMPfam hit to PF02278, Lyase_8, score 6.5e-34 936155006365 HMMPfam hit to PF08124, Lyase_8_N, score 2.4e-63 936155006366 1 probable transmembrane helix predicted for Hfelis14140 by TMHMM2.0 at aa 7-25 936155006367 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 936155006368 HMMPfam hit to PF05437, AzlD, score 6.9e-16 936155006369 3 probable transmembrane helices predicted for Hfelis14150 by TMHMM2.0 at aa 5-27, 39-58 and 73-95 936155006370 AzlC protein; Region: AzlC; cl00570 936155006371 7 probable transmembrane helices predicted for Hfelis14160 by TMHMM2.0 at aa 10-32, 37-59, 63-80, 128-150, 160-177, 184-201 and 205-220 936155006372 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006373 HMMPfam hit to PF03591, AzlC, score 1.5e-48 936155006374 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 936155006375 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936155006376 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936155006377 ABC-2 type transporter; Region: ABC2_membrane; cl17235 936155006378 6 probable transmembrane helices predicted for Hfelis14170 by TMHMM2.0 at aa 20-42, 181-203, 224-246, 261-283, 290-312 and 347-369 936155006379 HMMPfam hit to PF01061, ABC2_membrane, score 6.4e-09 936155006380 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006381 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936155006382 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 936155006383 7 probable transmembrane helices predicted for Hfelis14180 by TMHMM2.0 at aa 10-29, 106-128, 175-197, 209-228, 238-260, 267-289 and 322-344 936155006384 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 936155006385 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936155006386 HlyD family secretion protein; Region: HlyD_3; pfam13437 936155006387 HMMPfam hit to PF00529, HlyD, score 3.9e-07 936155006388 1 probable transmembrane helix predicted for Hfelis14190 by TMHMM2.0 at aa 9-31 936155006389 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 936155006390 Outer membrane efflux protein; Region: OEP; pfam02321 936155006391 Outer membrane efflux protein; Region: OEP; pfam02321 936155006392 HMMPfam hit to PF02321, OEP, score 2.6e-09 936155006393 HMMPfam hit to PF02321, OEP, score 4.4e-19 936155006394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936155006395 Domain of unknown function DUF21; Region: DUF21; pfam01595 936155006396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936155006397 Transporter associated domain; Region: CorC_HlyC; smart01091 936155006398 HMMPfam hit to PF03471, CorC_HlyC, score 4.6e-18 936155006399 HMMPfam hit to PF00571, CBS, score 5.4e-23 936155006400 HMMPfam hit to PF01595, DUF21, score 1.6e-68 936155006401 4 probable transmembrane helices predicted for Hfelis14210 by TMHMM2.0 at aa 7-29, 69-91, 104-126 and 141-163 936155006402 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 936155006403 Phosphate transporter family; Region: PHO4; cl00396 936155006404 13 probable transmembrane helices predicted for Hfelis14220 by TMHMM2.0 at aa 21-43, 47-69, 82-104, 124-143, 156-178, 182-204, 217-239, 252-274, 287-309, 337-359, 379-398, 403-420 and 506-528 936155006405 HMMPfam hit to PF01384, PHO4, score 2.9e-126 936155006406 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 936155006407 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936155006408 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936155006409 inhibitor-cofactor binding pocket; inhibition site 936155006410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936155006411 catalytic residue [active] 936155006412 HMMPfam hit to PF01041, DegT_DnrJ_EryC1, score 9.1e-118 936155006413 PS00923 Aspartate and glutamate racemases signature 1 936155006414 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006415 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 936155006416 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 936155006417 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 936155006418 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 936155006419 HMMPfam hit to PF03382, DUF285, score 2.2e-48 936155006420 HMMPfam hit to PF03382, DUF285, score 6e-28 936155006421 HMMPfam hit to PF03382, DUF285, score 1.7e-54 936155006422 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006423 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006424 HMMPfam hit to PF01856, HP_OMP, score 5.2e-63 936155006425 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006426 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006427 1 probable transmembrane helix predicted for Hfelis14280 by TMHMM2.0 at aa 7-29 936155006428 HMMPfam hit to PF01856, HP_OMP, score 3e-57 936155006429 1 probable transmembrane helix predicted for Hfelis14290 by TMHMM2.0 at aa 10-32 936155006430 1 probable transmembrane helix predicted for Hfelis14300 by TMHMM2.0 at aa 177-196 936155006431 1 probable transmembrane helix predicted for Hfelis14310 by TMHMM2.0 at aa 7-26 936155006432 1 probable transmembrane helix predicted for Hfelis14320 by TMHMM2.0 at aa 5-27 936155006433 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006434 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 936155006435 Cytochrome c; Region: Cytochrom_C; pfam00034 936155006436 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 936155006437 HMMPfam hit to PF00034, Cytochrom_C, score 0.00011 936155006438 2 probable transmembrane helices predicted for Hfelis14330 by TMHMM2.0 at aa 7-29 and 64-86 936155006439 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 936155006440 HMMPfam hit to PF09672, Cbb3_Q_epsi, score 1.7e-26 936155006441 1 probable transmembrane helix predicted for Hfelis14340 by TMHMM2.0 at aa 5-27 936155006442 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 936155006443 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 936155006444 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 936155006445 HMMPfam hit to PF02433, FixO, score 8.4e-100 936155006446 1 probable transmembrane helix predicted for Hfelis14350 by TMHMM2.0 at aa 10-32 936155006447 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 936155006448 Low-spin heme binding site [chemical binding]; other site 936155006449 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 936155006450 D-pathway; other site 936155006451 Putative water exit pathway; other site 936155006452 Binuclear center (active site) [active] 936155006453 K-pathway; other site 936155006454 Putative proton exit pathway; other site 936155006455 12 probable transmembrane helices predicted for Hfelis14360 by TMHMM2.0 at aa 29-51, 71-93, 113-135, 145-167, 174-193, 228-250, 257-279, 294-316, 328-350, 365-387, 408-427 and 456-478 936155006456 HMMPfam hit to PF00115, COX1, score 3.6e-34 936155006457 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature 936155006458 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 936155006459 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 936155006460 generic binding surface I; other site 936155006461 generic binding surface II; other site 936155006462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936155006463 ATP binding site [chemical binding]; other site 936155006464 putative Mg++ binding site [ion binding]; other site 936155006465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936155006466 nucleotide binding region [chemical binding]; other site 936155006467 ATP-binding site [chemical binding]; other site 936155006468 HMMPfam hit to PF00271, Helicase_C, score 6.7e-12 936155006469 HMMPfam hit to PF00270, DEAD, score 6.9e-20 936155006470 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006471 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006472 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006473 HMMPfam hit to PF01856, HP_OMP, score 4.7e-42 936155006474 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 936155006475 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936155006476 HMMPfam hit to PF00698, Acyl_transf_1, score 3.1e-06 936155006477 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006478 HMMPfam hit to PF02521, HP_OMP_2, score 5.4e-171 936155006479 1 probable transmembrane helix predicted for Hfelis14410 by TMHMM2.0 at aa 13-35 936155006480 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006481 HMMPfam hit to PF02521, HP_OMP_2, score 4.3e-249 936155006482 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006483 HMMPfam hit to PF02521, HP_OMP_2, score 1.2e-190 936155006484 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006485 HMMPfam hit to PF02521, HP_OMP_2, score 2e-224 936155006486 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006487 HMMPfam hit to PF02521, HP_OMP_2, score 2.1e-162 936155006488 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006489 HMMPfam hit to PF02521, HP_OMP_2, score 6.7e-173 936155006490 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 936155006491 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 936155006492 dimer interface [polypeptide binding]; other site 936155006493 putative functional site; other site 936155006494 putative MPT binding site; other site 936155006495 HMMPfam hit to PF03454, MoeA_C, score 0.0048 936155006496 HMMPfam hit to PF00994, MoCF_biosynth, score 1.5e-44 936155006497 PS01079 Molybdenum cofactor biosynthesis proteins signature 2 936155006498 HMMPfam hit to PF03453, MoeA_N, score 4e-44 936155006499 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 936155006500 HMMPfam hit to PF01311, Bac_export_1, score 1.2e-67 936155006501 6 probable transmembrane helices predicted for Hfelis14480 by TMHMM2.0 at aa 15-33, 40-59, 69-91, 128-150, 182-204 and 211-233 936155006502 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 936155006503 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 936155006504 substrate binding site [chemical binding]; other site 936155006505 hexamer interface [polypeptide binding]; other site 936155006506 metal binding site [ion binding]; metal-binding site 936155006507 HMMPfam hit to PF00834, Ribul_P_3_epim, score 2.6e-105 936155006508 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006509 PS01086 Ribulose-phosphate 3-epimerase family signature 2 936155006510 PS01085 Ribulose-phosphate 3-epimerase family signature 1 936155006511 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 936155006512 HMMPfam hit to PF01098, FTSW_RODA_SPOVE, score 1.5e-107 936155006513 9 probable transmembrane helices predicted for Hfelis14500 by TMHMM2.0 at aa 13-35, 45-62, 69-88, 132-154, 159-178, 182-201, 266-288, 303-325 and 332-354 936155006514 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature 936155006515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 936155006516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936155006517 catalytic residue [active] 936155006518 HMMPfam hit to PF01168, Ala_racemase_N, score 5.8e-42 936155006519 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 936155006520 HMMPfam hit to PF01977, UbiD, score 3.1e-135 936155006521 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 936155006522 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 936155006523 ligand binding site [chemical binding]; other site 936155006524 NAD binding site [chemical binding]; other site 936155006525 dimerization interface [polypeptide binding]; other site 936155006526 catalytic site [active] 936155006527 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 936155006528 putative L-serine binding site [chemical binding]; other site 936155006529 HMMPfam hit to PF01842, ACT, score 1.4e-08 936155006530 HMMPfam hit to PF00389, 2-Hacid_dh, score 1.5e-41 936155006531 HMMPfam hit to PF02826, 2-Hacid_dh_C, score 5.9e-78 936155006532 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature 936155006533 1 probable transmembrane helix predicted for Hfelis14540 by TMHMM2.0 at aa 5-27 936155006534 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 936155006535 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 936155006536 RNA binding site [nucleotide binding]; other site 936155006537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 936155006538 RNA binding site [nucleotide binding]; other site 936155006539 S1 RNA binding domain; Region: S1; pfam00575 936155006540 RNA binding site [nucleotide binding]; other site 936155006541 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 936155006542 RNA binding site [nucleotide binding]; other site 936155006543 S1 RNA binding domain; Region: S1; pfam00575 936155006544 RNA binding site [nucleotide binding]; other site 936155006545 HMMPfam hit to PF00575, S1, score 4.8e-12 936155006546 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site 936155006547 HMMPfam hit to PF00575, S1, score 3.7e-20 936155006548 HMMPfam hit to PF00575, S1, score 7.9e-28 936155006549 HMMPfam hit to PF00575, S1, score 1.6e-17 936155006550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 936155006551 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 936155006552 Substrate binding site; other site 936155006553 metal-binding site 936155006554 HMMPfam hit to PF00535, Glycos_transf_2, score 3e-19 936155006555 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 936155006556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 936155006557 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006558 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 936155006559 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 936155006560 putative active site [active] 936155006561 substrate binding site [chemical binding]; other site 936155006562 putative cosubstrate binding site; other site 936155006563 catalytic site [active] 936155006564 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 936155006565 substrate binding site [chemical binding]; other site 936155006566 HMMPfam hit to PF00551, Formyl_trans_N, score 3.5e-19 936155006567 HMMPfam hit to PF02911, Formyl_trans_C, score 3.1e-24 936155006568 biotin--protein ligase; Provisional; Region: PRK08477 936155006569 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 936155006570 HMMPfam hit to PF03099, BPL_LipA_LipB, score 2.9e-08 936155006571 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 936155006572 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 936155006573 1 probable transmembrane helix predicted for Hfelis14610 by TMHMM2.0 at aa 7-29 936155006574 HMMPfam hit to PF00430, ATP-synt_B, score 4.7e-07 936155006575 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 936155006576 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 936155006577 HMMPfam hit to PF00430, ATP-synt_B, score 3e-07 936155006578 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 936155006579 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 936155006580 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 936155006581 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936155006582 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 936155006583 beta subunit interaction interface [polypeptide binding]; other site 936155006584 Walker A motif; other site 936155006585 ATP binding site [chemical binding]; other site 936155006586 Walker B motif; other site 936155006587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936155006588 HMMPfam hit to PF02874, ATP-synt_ab_N, score 6e-12 936155006589 HMMPfam hit to PF00006, ATP-synt_ab, score 9.4e-129 936155006590 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006591 PS00152 ATP synthase alpha and beta subunits signature 936155006592 HMMPfam hit to PF00306, ATP-synt_ab_C, score 1.5e-34 936155006593 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 936155006594 core domain interface [polypeptide binding]; other site 936155006595 delta subunit interface [polypeptide binding]; other site 936155006596 epsilon subunit interface [polypeptide binding]; other site 936155006597 HMMPfam hit to PF00231, ATP-synt, score 9.1e-88 936155006598 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 936155006599 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936155006600 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 936155006601 alpha subunit interaction interface [polypeptide binding]; other site 936155006602 Walker A motif; other site 936155006603 ATP binding site [chemical binding]; other site 936155006604 Walker B motif; other site 936155006605 inhibitor binding site; inhibition site 936155006606 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936155006607 HMMPfam hit to PF02874, ATP-synt_ab_N, score 4.8e-23 936155006608 HMMPfam hit to PF00006, ATP-synt_ab, score 2.5e-97 936155006609 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006610 PS00152 ATP synthase alpha and beta subunits signature 936155006611 HMMPfam hit to PF00306, ATP-synt_ab_C, score 2.2e-49 936155006612 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 936155006613 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 936155006614 gamma subunit interface [polypeptide binding]; other site 936155006615 epsilon subunit interface [polypeptide binding]; other site 936155006616 LBP interface [polypeptide binding]; other site 936155006617 HMMPfam hit to PF02823, ATP-synt_DE_N, score 8.7e-28 936155006618 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 936155006619 3 probable transmembrane helices predicted for Hfelis14680 by TMHMM2.0 at aa 13-35, 93-115 and 135-157 936155006620 HMMPfam hit to PF01618, MotA_ExbB, score 1.9e-29 936155006621 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 936155006622 TolR protein; Region: tolR; TIGR02801 936155006623 HMMPfam hit to PF02472, ExbD, score 6.6e-30 936155006624 1 probable transmembrane helix predicted for Hfelis14690 by TMHMM2.0 at aa 15-37 936155006625 Gram-negative bacterial tonB protein; Region: TonB; cl10048 936155006626 1 probable transmembrane helix predicted for Hfelis14700 by TMHMM2.0 at aa 5-27 936155006627 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006628 translocation protein TolB; Provisional; Region: tolB; PRK04043 936155006629 TolB amino-terminal domain; Region: TolB_N; pfam04052 936155006630 HMMPfam hit to PF04052, TolB_N, score 1e-20 936155006631 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 936155006632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936155006633 ligand binding site [chemical binding]; other site 936155006634 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006635 HMMPfam hit to PF00691, OmpA, score 7e-29 936155006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 936155006637 PS00443 Glutamine amidotransferases class-II active site 936155006638 PS00761 Signal peptidases I signature 3 936155006639 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006640 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 936155006641 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936155006642 HMMPfam hit to PF00254, FKBP_C, score 1.1e-10 936155006643 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 936155006644 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 936155006645 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 936155006646 HMMPfam hit to PF03447, NAD_binding_3, score 1.8e-14 936155006647 HMMPfam hit to PF00742, Homoserine_dh, score 1.4e-63 936155006648 PS01042 Homoserine dehydrogenase signature 936155006649 hypothetical protein; Reviewed; Region: PRK12497 936155006650 HMMPfam hit to PF02021, UPF0102, score 1.9e-21 936155006651 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936155006652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936155006653 catalytic residues [active] 936155006654 HMMPfam hit to PF00085, Thioredoxin, score 2.8e-45 936155006655 PS00194 Thioredoxin family active site 936155006656 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 936155006657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936155006658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936155006659 HMMPfam hit to PF07992, Pyr_redox_2, score 1.4e-49 936155006660 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site 936155006661 dihydrodipicolinate reductase; Provisional; Region: PRK00048 936155006662 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 936155006663 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 936155006664 HMMPfam hit to PF01113, DapB_N, score 6.6e-34 936155006665 PS00211 ABC transporters family signature 936155006666 HMMPfam hit to PF05173, DapB_C, score 5.9e-59 936155006667 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 936155006668 Clp amino terminal domain; Region: Clp_N; pfam02861 936155006669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155006670 Walker A motif; other site 936155006671 ATP binding site [chemical binding]; other site 936155006672 Walker B motif; other site 936155006673 arginine finger; other site 936155006674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155006675 Walker A motif; other site 936155006676 ATP binding site [chemical binding]; other site 936155006677 Walker B motif; other site 936155006678 arginine finger; other site 936155006679 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 936155006680 HMMPfam hit to PF02861, Clp_N, score 1.1e-10 936155006681 HMMPfam hit to PF02861, Clp_N, score 0.52 936155006682 HMMPfam hit to PF00004, AAA, score 1.1e-20 936155006683 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006684 PS00870 Chaperonins clpA/B signature 1 936155006685 HMMPfam hit to PF07724, AAA_2, score 1.4e-106 936155006686 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006687 PS00871 Chaperonins clpA/B signature 2 936155006688 HMMPfam hit to PF10431, ClpB_D2-small, score 5.6e-34 936155006689 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 936155006690 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155006691 dimer interface [polypeptide binding]; other site 936155006692 putative CheW interface [polypeptide binding]; other site 936155006693 2 probable transmembrane helices predicted for Hfelis14810 by TMHMM2.0 at aa 10-29 and 210-232 936155006694 HMMPfam hit to PF08269, Cache_2, score 0.00067 936155006695 HMMPfam hit to PF00015, MCPsignal, score 1.3e-31 936155006696 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 936155006697 2-methylcitrate dehydratase; Region: prpD; TIGR02330 936155006698 HMMPfam hit to PF03972, MmgE_PrpD, score 7.2e-172 936155006699 Predicted helix-turn-helix motif with score 1007.000, SD 2.62 at aa 317-338, sequence DRLEEIAKIEITTQESGHRIIN 936155006700 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 936155006701 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 936155006702 tetramer interface [polypeptide binding]; other site 936155006703 active site 936155006704 Mg2+/Mn2+ binding site [ion binding]; other site 936155006705 HMMPfam hit to PF00463, ICL, score 3.9e-09 936155006706 8 probable transmembrane helices predicted for Hfelis14850 by TMHMM2.0 at aa 51-73, 80-102, 112-134, 155-177, 187-206, 219-236, 246-268 and 275-297 936155006707 10 probable transmembrane helices predicted for Hfelis14860 by TMHMM2.0 at aa 7-29, 42-59, 72-94, 98-120, 125-143, 148-170, 182-204, 219-238, 245-267 and 277-299 936155006708 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006709 HMMPfam hit to PF00892, DUF6, score 1.9e-12 936155006710 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006711 HMMPfam hit to PF01856, HP_OMP, score 2.2e-36 936155006712 PS00237 G-protein coupled receptors signature 936155006713 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 936155006714 active site 936155006715 HMMPfam hit to PF00316, FBPase, score 3.3e-29 936155006716 PS00124 Fructose-1-6-bisphosphatase active site 936155006717 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 936155006718 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 936155006719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936155006720 HMMPfam hit to PF01820, Dala_Dala_lig_N, score 5.5e-07 936155006721 PS00843 D-alanine--D-alanine ligase signature 1 936155006722 HMMPfam hit to PF07478, Dala_Dala_lig_C, score 2.5e-13 936155006723 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 936155006724 HMMPfam hit to PF00561, Abhydrolase_1, score 2.2e-05 936155006725 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 936155006726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936155006727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936155006728 4 probable transmembrane helices predicted for Hfelis14920 by TMHMM2.0 at aa 6-28, 41-60, 65-84 and 97-119 936155006729 HMMPfam hit to PF08245, Mur_ligase_M, score 1.8e-25 936155006730 HMMPfam hit to PF02875, Mur_ligase_C, score 0.016 936155006731 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 936155006732 nucleotide binding site/active site [active] 936155006733 HIT family signature motif; other site 936155006734 catalytic residue [active] 936155006735 HMMPfam hit to PF01230, HIT, score 0.00093 936155006736 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature 936155006737 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 936155006738 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 936155006739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936155006740 active site 936155006741 PS00114 Phosphoribosyl pyrophosphate synthetase signature 936155006742 HMMPfam hit to PF00156, Pribosyltran, score 2.5e-29 936155006743 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 936155006744 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 936155006745 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 936155006746 GDP-binding site [chemical binding]; other site 936155006747 ACT binding site; other site 936155006748 IMP binding site; other site 936155006749 HMMPfam hit to PF00709, Adenylsucc_synt, score 3.1e-237 936155006750 PS01266 Adenylosuccinate synthetase GTP-binding site 936155006751 PS00513 Adenylosuccinate synthetase active site 936155006752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006753 Flagellar FliJ protein; Region: FliJ; pfam02050 936155006754 Uncharacterized conserved protein [Function unknown]; Region: COG3334 936155006755 HMMPfam hit to PF03448, MgtE_N, score 1.5e-05 936155006756 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 936155006757 HMMPfam hit to PF09695, YtfJ_HI0045, score 3.1e-84 936155006758 Alginate lyase; Region: Alginate_lyase; pfam05426 936155006759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936155006760 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 936155006761 NAD(P) binding site [chemical binding]; other site 936155006762 active site 936155006763 HMMPfam hit to PF00106, adh_short, score 9.3e-31 936155006764 PS00061 Short-chain dehydrogenases/reductases family signature 936155006765 tellurium resistance terB-like protein; Region: terB_like; cl11965 936155006766 metal binding site [ion binding]; metal-binding site 936155006767 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 936155006768 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 936155006769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936155006770 catalytic residue [active] 936155006771 HMMPfam hit to PF00155, Aminotran_1_2, score 1.7e-20 936155006772 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site 936155006773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155006774 dimer interface [polypeptide binding]; other site 936155006775 putative CheW interface [polypeptide binding]; other site 936155006776 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 936155006777 HMMPfam hit to PF00015, MCPsignal, score 2.5e-44 936155006778 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155006779 HMMPfam hit to PF02521, HP_OMP_2, score 5.3e-178 936155006780 PS00687 Aldehyde dehydrogenases glutamic acid active site 936155006781 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 936155006782 HMMPfam hit to PF09411, PagL, score 5e-07 936155006783 1 probable transmembrane helix predicted for Hfelis15130 by TMHMM2.0 at aa 65-84 936155006784 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 936155006785 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 936155006786 tetramer interface [polypeptide binding]; other site 936155006787 heme binding pocket [chemical binding]; other site 936155006788 NADPH binding site [chemical binding]; other site 936155006789 HMMPfam hit to PF00199, Catalase, score 2e-274 936155006790 PS00438 Catalase proximal active site signature 936155006791 PS00437 Catalase proximal heme-ligand signature 936155006792 HMMPfam hit to PF06628, Catalase-rel, score 6.4e-27 936155006793 2 probable transmembrane helices predicted for Hfelis15150 by TMHMM2.0 at aa 27-49 and 53-72 936155006794 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 936155006795 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 936155006796 12 probable transmembrane helices predicted for Hfelis15160 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 127-149, 154-176, 186-208, 241-263, 273-291, 312-334, 344-365, 377-394 and 404-426 936155006797 HMMPfam hit to PF01554, MatE, score 7.6e-17 936155006798 HMMPfam hit to PF01554, MatE, score 1.2e-39 936155006799 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006800 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 936155006801 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 936155006802 NADP-binding site; other site 936155006803 homotetramer interface [polypeptide binding]; other site 936155006804 substrate binding site [chemical binding]; other site 936155006805 homodimer interface [polypeptide binding]; other site 936155006806 active site 936155006807 HMMPfam hit to PF01370, Epimerase, score 8.9e-103 936155006808 PS00061 Short-chain dehydrogenases/reductases family signature 936155006809 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 936155006810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936155006811 active site 936155006812 Cupin domain; Region: Cupin_2; cl17218 936155006813 HMMPfam hit to PF01050, MannoseP_isomer, score 2.3e-45 936155006814 HMMPfam hit to PF00483, NTP_transferase, score 6.6e-32 936155006815 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006816 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 936155006817 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 936155006818 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 936155006819 HMMPfam hit to PF01243, Pyridox_oxidase, score 1.2e-07 936155006820 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936155006821 metal binding site 2 [ion binding]; metal-binding site 936155006822 putative DNA binding helix; other site 936155006823 metal binding site 1 [ion binding]; metal-binding site 936155006824 dimer interface [polypeptide binding]; other site 936155006825 structural Zn2+ binding site [ion binding]; other site 936155006826 HMMPfam hit to PF01475, FUR, score 1.7e-46 936155006827 pseudaminic acid synthase; Region: PseI; TIGR03586 936155006828 NeuB family; Region: NeuB; pfam03102 936155006829 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 936155006830 NeuB binding interface [polypeptide binding]; other site 936155006831 putative substrate binding site [chemical binding]; other site 936155006832 HMMPfam hit to PF08666, SAF, score 1e-08 936155006833 HMMPfam hit to PF03102, NeuB, score 2.8e-104 936155006834 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 936155006835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936155006836 HMMPfam hit to PF00583, Acetyltransf_1, score 7.6e-07 936155006837 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 936155006838 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 936155006839 ligand binding site; other site 936155006840 tetramer interface; other site 936155006841 HMMPfam hit to PF02348, CTP_transf_3, score 7.4e-30 936155006842 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 936155006843 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 936155006844 HMMPfam hit to PF02107, FlgH, score 1.9e-51 936155006845 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155006846 HMMPfam hit to PF01856, HP_OMP, score 1.1e-50 936155006847 nuclease NucT; Provisional; Region: PRK13912 936155006848 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 936155006849 putative active site [active] 936155006850 catalytic site [active] 936155006851 HMMPfam hit to PF00614, PLDc, score 1.2e-05 936155006852 Guanylate kinase; Region: Guanylate_kin; pfam00625 936155006853 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 936155006854 catalytic site [active] 936155006855 G-X2-G-X-G-K; other site 936155006856 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006857 PS00856 Guanylate kinase signature 936155006858 HMMPfam hit to PF00625, Guanylate_kin, score 2.2e-38 936155006859 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 936155006860 1 probable transmembrane helix predicted for Hfelis15300 by TMHMM2.0 at aa 4-23 936155006861 HMMPfam hit to PF02416, MttA_Hcf106, score 3.6e-23 936155006862 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 936155006863 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 936155006864 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 936155006865 active site 936155006866 HIGH motif; other site 936155006867 KMSK motif region; other site 936155006868 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 936155006869 tRNA binding surface [nucleotide binding]; other site 936155006870 anticodon binding site; other site 936155006871 HMMPfam hit to PF03485, Arg_tRNA_synt_N, score 3.9e-13 936155006872 HMMPfam hit to PF00750, tRNA-synt_1d, score 4.7e-69 936155006873 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155006874 HMMPfam hit to PF05746, DALR_1, score 6.1e-22 936155006875 primosome assembly protein PriA; Validated; Region: PRK05580 936155006876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936155006877 ATP binding site [chemical binding]; other site 936155006878 putative Mg++ binding site [ion binding]; other site 936155006879 helicase superfamily c-terminal domain; Region: HELICc; smart00490 936155006880 HMMPfam hit to PF00271, Helicase_C, score 2e-08 936155006881 HMMPfam hit to PF00270, DEAD, score 2.3e-21 936155006882 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936155006884 FeS/SAM binding site; other site 936155006885 HMMPfam hit to PF04055, Radical_SAM, score 1.7e-11 936155006886 excinuclease ABC subunit B; Provisional; Region: PRK05298 936155006887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936155006888 ATP binding site [chemical binding]; other site 936155006889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936155006890 nucleotide binding region [chemical binding]; other site 936155006891 ATP-binding site [chemical binding]; other site 936155006892 Ultra-violet resistance protein B; Region: UvrB; pfam12344 936155006893 UvrB/uvrC motif; Region: UVR; pfam02151 936155006894 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006895 HMMPfam hit to PF00271, Helicase_C, score 8.5e-18 936155006896 HMMPfam hit to PF02151, UVR, score 2.5e-06 936155006897 1 probable transmembrane helix predicted for Hfelis15370 by TMHMM2.0 at aa 10-32 936155006898 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 936155006899 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936155006900 active site 936155006901 HIGH motif; other site 936155006902 KMSKS motif; other site 936155006903 HMMPfam hit to PF00749, tRNA-synt_1c, score 8.7e-139 936155006904 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 936155006905 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 936155006906 active site 936155006907 catalytic site [active] 936155006908 substrate binding site [chemical binding]; other site 936155006909 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 936155006910 HMMPfam hit to PF10108, Exon_PolB, score 6e-85 936155006911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 936155006912 TPR repeat; Region: TPR_11; pfam13414 936155006913 binding surface 936155006914 TPR motif; other site 936155006915 Sel1-like repeats; Region: SEL1; smart00671 936155006916 Sel1 repeat; Region: Sel1; cl02723 936155006917 HMMPfam hit to PF08238, Sel1, score 6.4e-05 936155006918 HMMPfam hit to PF08238, Sel1, score 3.3e-09 936155006919 HMMPfam hit to PF08238, Sel1, score 7.1e-05 936155006920 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006921 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 936155006922 thiamine phosphate binding site [chemical binding]; other site 936155006923 active site 936155006924 pyrophosphate binding site [ion binding]; other site 936155006925 HMMPfam hit to PF02581, TMP-TENI, score 5.2e-75 936155006926 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006927 GMP synthase; Reviewed; Region: guaA; PRK00074 936155006928 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 936155006929 AMP/PPi binding site [chemical binding]; other site 936155006930 candidate oxyanion hole; other site 936155006931 catalytic triad [active] 936155006932 potential glutamine specificity residues [chemical binding]; other site 936155006933 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 936155006934 ATP Binding subdomain [chemical binding]; other site 936155006935 Ligand Binding sites [chemical binding]; other site 936155006936 Dimerization subdomain; other site 936155006937 HMMPfam hit to PF00958, GMP_synt_C, score 6.9e-68 936155006938 HMMPfam hit to PF03054, tRNA_Me_trans, score 1.2e-07 936155006939 HMMPfam hit to PF00117, GATase, score 6.3e-55 936155006940 PS00442 Glutamine amidotransferases class-I active site 936155006941 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 936155006942 4Fe-4S binding domain; Region: Fer4_5; pfam12801 936155006943 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936155006944 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 936155006945 5 probable transmembrane helices predicted for Hfelis15440 by TMHMM2.0 at aa 21-40, 67-89, 139-161, 176-198 and 322-341 936155006946 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 936155006947 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 936155006948 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 936155006949 HMMPfam hit to PF01924, HypD, score 3.4e-206 936155006950 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 936155006951 HMMPfam hit to PF01455, HupF_HypC, score 2.9e-25 936155006952 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature 936155006953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936155006954 HMMPfam hit to PF02492, cobW, score 1.1e-50 936155006955 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 936155006956 PS00092 N-6 Adenine-specific DNA methylases signature 936155006957 HMMPfam hit to PF04313, HSDR_N, score 0.00018 936155006958 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936155006959 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 936155006960 11 probable transmembrane helices predicted for Hfelis15490 by TMHMM2.0 at aa 13-32, 36-58, 84-106, 126-148, 153-170, 190-212, 233-255, 285-307, 328-345, 355-377 and 389-407 936155006961 HMMPfam hit to PF03222, Trp_Tyr_perm, score 8.6e-05 936155006962 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006963 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006964 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155006965 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936155006966 DNA methylase; Region: N6_N4_Mtase; cl17433 936155006967 HMMPfam hit to PF01555, N6_N4_Mtase, score 1e-12 936155006968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155006969 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 936155006970 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936155006971 nucleotide binding site [chemical binding]; other site 936155006972 6 probable transmembrane helices predicted for Hfelis15590 by TMHMM2.0 at aa 5-22, 42-64, 84-106, 110-132, 167-189 and 193-212 936155006973 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 268-289, sequence WELWDLAESLSVSRATFVRFEK 936155006974 potential frameshift: common BLAST hit: gi|315453962|ref|YP_004074232.1| chaperone protein dnaK 936155006975 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 936155006976 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 936155006977 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 936155006978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936155006979 Walker A motif; other site 936155006980 ATP binding site [chemical binding]; other site 936155006981 Walker B motif; other site 936155006982 HMMPfam hit to PF07724, AAA_2, score 1.1e-69 936155006983 PS00017 ATP/GTP-binding site motif A (P-loop) 936155006984 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 936155006985 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 936155006986 substrate binding site [chemical binding]; other site 936155006987 active site 936155006988 HMMPfam hit to PF01208, URO-D, score 1.2e-122 936155006989 PS00907 Uroporphyrinogen decarboxylase signature 2 936155006990 PS00906 Uroporphyrinogen decarboxylase signature 1 936155006991 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936155006992 minor groove reading motif; other site 936155006993 helix-hairpin-helix signature motif; other site 936155006994 active site 936155006995 HMMPfam hit to PF00730, HhH-GPD, score 6.3e-10 936155006996 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 936155006997 active site 936155006998 Zn binding site [ion binding]; other site 936155006999 Protein of unknown function (DUF511); Region: DUF511; cl01114 936155007000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007001 binding surface 936155007002 TPR repeat; Region: TPR_11; pfam13414 936155007003 TPR motif; other site 936155007004 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007005 Sel1-like repeats; Region: SEL1; smart00671 936155007006 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007007 Sel1-like repeats; Region: SEL1; smart00671 936155007008 Sel1-like repeats; Region: SEL1; smart00671 936155007009 Sel1-like repeats; Region: SEL1; smart00671 936155007010 Sel1-like repeats; Region: SEL1; smart00671 936155007011 Sel1-like repeats; Region: SEL1; smart00671 936155007012 HMMPfam hit to PF08238, Sel1, score 5e-09 936155007013 HMMPfam hit to PF08238, Sel1, score 8.3e-08 936155007014 HMMPfam hit to PF08238, Sel1, score 0.0019 936155007015 HMMPfam hit to PF08238, Sel1, score 0.036 936155007016 HMMPfam hit to PF08238, Sel1, score 8.3e-08 936155007017 HMMPfam hit to PF08238, Sel1, score 3.6e-09 936155007018 HMMPfam hit to PF08238, Sel1, score 1.3e-09 936155007019 HMMPfam hit to PF08238, Sel1, score 1.5e-09 936155007020 HMMPfam hit to PF08238, Sel1, score 1e-06 936155007021 HMMPfam hit to PF08238, Sel1, score 0.0008 936155007022 HMMPfam hit to PF08238, Sel1, score 5.5e-05 936155007023 HMMPfam hit to PF08238, Sel1, score 4.9e-08 936155007024 HMMPfam hit to PF08238, Sel1, score 2.4e-08 936155007025 HMMPfam hit to PF08238, Sel1, score 1.6e-11 936155007026 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007027 Sel1-like repeats; Region: SEL1; smart00671 936155007028 HMMPfam hit to PF08238, Sel1, score 0.00039 936155007029 HMMPfam hit to PF08238, Sel1, score 5e-06 936155007030 HMMPfam hit to PF08238, Sel1, score 2e-08 936155007031 1 probable transmembrane helix predicted for Hfelis15760 by TMHMM2.0 at aa 7-29 936155007032 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155007033 1 probable transmembrane helix predicted for Hfelis15780 by TMHMM2.0 at aa 7-29 936155007034 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 936155007035 Initiator Replication protein; Region: Rep_3; pfam01051 936155007036 Protein of unknown function (DUF972); Region: DUF972; pfam06156 936155007037 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 936155007038 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 936155007039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936155007040 ATP binding site [chemical binding]; other site 936155007041 putative Mg++ binding site [ion binding]; other site 936155007042 HMMPfam hit to PF04851, ResIII, score 1.2e-43 936155007043 HMMPfam hit to PF04313, HSDR_N, score 1e-46 936155007044 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 936155007045 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155007046 HMMPfam hit to PF01420, Methylase_S, score 5.9e-13 936155007047 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 936155007048 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155007049 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936155007050 HMMPfam hit to PF01420, Methylase_S, score 7.5e-12 936155007051 HMMPfam hit to PF01420, Methylase_S, score 1.9e-23 936155007052 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155007053 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 936155007054 HsdM N-terminal domain; Region: HsdM_N; pfam12161 936155007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936155007056 S-adenosylmethionine binding site [chemical binding]; other site 936155007057 HMMPfam hit to PF02384, N6_Mtase, score 5.3e-163 936155007058 PS00092 N-6 Adenine-specific DNA methylases signature 936155007059 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007061 TPR motif; other site 936155007062 binding surface 936155007063 HMMPfam hit to PF08238, Sel1, score 9e-13 936155007064 HMMPfam hit to PF08238, Sel1, score 0.00012 936155007065 HMMPfam hit to PF08238, Sel1, score 0.026 936155007066 HMMPfam hit to PF08238, Sel1, score 0.0091 936155007067 Nitrate and nitrite sensing; Region: NIT; pfam08376 936155007068 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155007069 HAMP domain; Region: HAMP; pfam00672 936155007070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155007071 dimer interface [polypeptide binding]; other site 936155007072 putative CheW interface [polypeptide binding]; other site 936155007073 HMMPfam hit to PF00015, MCPsignal, score 3.6e-32 936155007074 HMMPfam hit to PF00672, HAMP, score 4.9e-09 936155007075 2 probable transmembrane helices predicted for Hfelis16390 by TMHMM2.0 at aa 13-32 and 311-333 936155007076 HMMPfam hit to PF08376, NIT, score 3.2e-54 936155007077 Initiator Replication protein; Region: Rep_3; pfam01051 936155007078 HMMPfam hit to PF01051, Rep_3, score 2.5e-13 936155007079 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 936155007080 HMMPfam hit to PF02521, HP_OMP_2, score 6.3e-162 936155007081 1 probable transmembrane helix predicted for Hfelis16410 by TMHMM2.0 at aa 13-30 936155007082 Sel1-like repeats; Region: SEL1; smart00671 936155007083 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007085 TPR motif; other site 936155007086 binding surface 936155007087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007088 binding surface 936155007089 TPR motif; other site 936155007090 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 936155007091 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 936155007092 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936155007093 NlpC/P60 family; Region: NLPC_P60; cl17555 936155007094 HMMPfam hit to PF00877, NLPC_P60, score 1.7e-07 936155007095 HMMPfam hit to PF08238, Sel1, score 1.1e-05 936155007096 HMMPfam hit to PF08238, Sel1, score 0.8 936155007097 HMMPfam hit to PF08238, Sel1, score 5.1e-10 936155007098 HMMPfam hit to PF08238, Sel1, score 8.3e-06 936155007099 HMMPfam hit to PF08238, Sel1, score 3.5e-06 936155007100 HMMPfam hit to PF08238, Sel1, score 0.014 936155007101 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007102 Sel1-like repeats; Region: SEL1; smart00671 936155007103 HMMPfam hit to PF08238, Sel1, score 5.5e-05 936155007104 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155007105 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 936155007106 Sulfatase; Region: Sulfatase; pfam00884 936155007107 5 probable transmembrane helices predicted for Hfelis16440 by TMHMM2.0 at aa 7-26, 30-52, 73-95, 115-137 and 150-167 936155007108 HMMPfam hit to PF00884, Sulfatase, score 7.2e-57 936155007109 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155007110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155007111 dimer interface [polypeptide binding]; other site 936155007112 putative CheW interface [polypeptide binding]; other site 936155007113 HMMPfam hit to PF00015, MCPsignal, score 1.2e-30 936155007114 1 probable transmembrane helix predicted for Hfelis16450 by TMHMM2.0 at aa 12-31 936155007115 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155007116 HMMPfam hit to PF01856, HP_OMP, score 0.0021 936155007117 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155007118 HMMPfam hit to PF01856, HP_OMP, score 2.1e-27 936155007119 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936155007120 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 936155007121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936155007122 catalytic residue [active] 936155007123 HMMPfam hit to PF00282, Pyridoxal_deC, score 1.4e-61 936155007124 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 936155007125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936155007126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007127 TPR motif; other site 936155007128 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007129 binding surface 936155007130 Sel1-like repeats; Region: SEL1; smart00671 936155007131 Sel1-like repeats; Region: SEL1; smart00671 936155007132 Sel1-like repeats; Region: SEL1; smart00671 936155007133 HMMPfam hit to PF08238, Sel1, score 5.1e-12 936155007134 HMMPfam hit to PF08238, Sel1, score 7.2e-06 936155007135 HMMPfam hit to PF08238, Sel1, score 1.6e-07 936155007136 HMMPfam hit to PF08238, Sel1, score 1.3e-10 936155007137 HMMPfam hit to PF08238, Sel1, score 8.6e-12 936155007138 HMMPfam hit to PF08238, Sel1, score 3.9e-09 936155007139 HMMPfam hit to PF08238, Sel1, score 1.3e-10 936155007140 HMMPfam hit to PF08238, Sel1, score 2.4e-07 936155007141 HMMPfam hit to PF08238, Sel1, score 2.1e-10 936155007142 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007144 TPR motif; other site 936155007145 binding surface 936155007146 HMMPfam hit to PF08238, Sel1, score 1.5e-08 936155007147 HMMPfam hit to PF08238, Sel1, score 6.8e-12 936155007148 HMMPfam hit to PF08238, Sel1, score 3.9e-11 936155007149 HMMPfam hit to PF08238, Sel1, score 0.0023 936155007150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007151 TPR motif; other site 936155007152 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007153 binding surface 936155007154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007155 binding surface 936155007156 TPR motif; other site 936155007157 Sel1-like repeats; Region: SEL1; smart00671 936155007158 HMMPfam hit to PF08238, Sel1, score 3.5e-08 936155007159 HMMPfam hit to PF08238, Sel1, score 4.5e-08 936155007160 HMMPfam hit to PF08238, Sel1, score 1.2e-06 936155007161 HMMPfam hit to PF08238, Sel1, score 7.8e-12 936155007162 HMMPfam hit to PF08238, Sel1, score 4.2e-11 936155007163 HMMPfam hit to PF08238, Sel1, score 2e-06 936155007164 HMMPfam hit to PF08238, Sel1, score 1.2e-11 936155007165 Sel1-like repeats; Region: SEL1; smart00671 936155007166 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007168 binding surface 936155007169 TPR motif; other site 936155007170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007171 binding surface 936155007172 TPR motif; other site 936155007173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007174 binding surface 936155007175 TPR motif; other site 936155007176 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936155007178 binding surface 936155007179 TPR motif; other site 936155007180 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936155007181 Sel1-like repeats; Region: SEL1; smart00671 936155007182 Sel1-like repeats; Region: SEL1; smart00671 936155007183 HMMPfam hit to PF08238, Sel1, score 6e-13 936155007184 HMMPfam hit to PF08238, Sel1, score 4e-10 936155007185 HMMPfam hit to PF08238, Sel1, score 1.5e-12 936155007186 HMMPfam hit to PF08238, Sel1, score 1.9e-10 936155007187 HMMPfam hit to PF08238, Sel1, score 6.6e-09 936155007188 HMMPfam hit to PF08238, Sel1, score 1.2e-11 936155007189 HMMPfam hit to PF08238, Sel1, score 3.4e-10 936155007190 HMMPfam hit to PF08238, Sel1, score 7.3e-12 936155007191 HMMPfam hit to PF08238, Sel1, score 2.2e-11 936155007192 HMMPfam hit to PF08238, Sel1, score 5.9e-12 936155007193 HMMPfam hit to PF08238, Sel1, score 1.4e-10 936155007194 HMMPfam hit to PF08238, Sel1, score 2.3e-05 936155007195 HMMPfam hit to PF08238, Sel1, score 2.8e-10 936155007196 Initiator Replication protein; Region: Rep_3; pfam01051 936155007197 HMMPfam hit to PF01051, Rep_3, score 1.9e-28 936155007198 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 936155007199 1 probable transmembrane helix predicted for Hfelis00230 by TMHMM2.0 at aa 7-29 936155007200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936155007201 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 936155007202 Walker A/P-loop; other site 936155007203 ATP binding site [chemical binding]; other site 936155007204 Q-loop/lid; other site 936155007205 ABC transporter signature motif; other site 936155007206 Walker B; other site 936155007207 D-loop; other site 936155007208 H-loop/switch region; other site 936155007209 HMMPfam hit to PF00005, ABC_tran, score 1.3e-30 936155007210 PS00017 ATP/GTP-binding site motif A (P-loop) 936155007211 4 probable transmembrane helices predicted for Hfelis00240 by TMHMM2.0 at aa 20-42, 63-85, 151-173 and 255-277 936155007212 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 936155007213 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 936155007214 PS00017 ATP/GTP-binding site motif A (P-loop) 936155007215 HMMPfam hit to PF01051, Rep_3, score 1e-25 936155007216 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155007217 HMMPfam hit to PF01856, HP_OMP, score 8.5e-18 936155007218 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 936155007219 HMMPfam hit to PF01856, HP_OMP, score 6e-13 936155007220 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 936155007221 HMMPfam hit to PF01522, Polysacc_deac_1, score 2.3e-12 936155007222 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 936155007223 11 probable transmembrane helices predicted for Hfelis00100 by TMHMM2.0 at aa 5-27, 42-64, 77-96, 111-133, 153-175, 248-270, 309-331, 335-357, 369-391, 424-441 and 454-476 936155007224 HMMPfam hit to PF03062, MBOAT, score 4.9e-47 936155007225 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 936155007226 classical (c) SDRs; Region: SDR_c; cd05233 936155007227 NAD(P) binding site [chemical binding]; other site 936155007228 active site 936155007229 HMMPfam hit to PF00106, adh_short, score 0.00022 936155007230 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 936155007231 active site 2 [active] 936155007232 active site 1 [active] 936155007233 HMMPfam hit to PF01575, MaoC_dehydratas, score 3.1e-06 936155007234 PS00430 TonB-dependent receptor proteins signature 1 936155007235 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 936155007236 active site 2 [active] 936155007237 active site 1 [active] 936155007238 HMMPfam hit to PF01575, MaoC_dehydratas, score 1.1e-18 936155007239 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 936155007240 FkbH-like domain; Region: FkbH; TIGR01686 936155007241 Acid Phosphatase; Region: Acid_PPase; cl17256 936155007242 Fic/DOC family; Region: Fic; cl00960 936155007243 HMMPfam hit to PF02661, Fic, score 2.2e-12 936155007244 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 936155007245 AAA domain; Region: AAA_25; pfam13481 936155007246 Walker B motif; other site 936155007247 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 936155007248 Fic family protein [Function unknown]; Region: COG3177 936155007249 Fic/DOC family; Region: Fic; pfam02661 936155007250 HMMPfam hit to PF02661, Fic, score 6.1e-15 936155007251 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 936155007252 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 936155007253 catalytic nucleophile [active] 936155007254 HMMPfam hit to PF00239, Resolvase, score 1.9e-07 936155007255 PS00397 Site-specific recombinases active site 936155007256 HMMPfam hit to PF00239, Resolvase, score 2.9e-20 936155007257 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 936155007258 HMMPfam hit to PF00884, Sulfatase, score 2.7e-11 936155007259 HMMPfam hit to PF00884, Sulfatase, score 7.9e-10 936155007260 5 probable transmembrane helices predicted for Hfelis16080 by TMHMM2.0 at aa 5-24, 34-56, 69-88, 120-142 and 149-168 936155007261 Initiator Replication protein; Region: Rep_3; pfam01051 936155007262 HMMPfam hit to PF01051, Rep_3, score 0.00066 936155007263 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 936155007264 HMMPfam hit to PF02525, Flavodoxin_2, score 1.2e-38 936155007265 Pirin-related protein [General function prediction only]; Region: COG1741 936155007266 Pirin; Region: Pirin; pfam02678 936155007267 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 936155007268 HMMPfam hit to PF02678, Pirin, score 7.1e-44 936155007269 HMMPfam hit to PF05726, Pirin_C, score 3.4e-30 936155007270 Initiator Replication protein; Region: Rep_3; pfam01051 936155007271 HMMPfam hit to PF01051, Rep_3, score 8.5e-15 936155007272 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 936155007273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936155007274 dimer interface [polypeptide binding]; other site 936155007275 putative CheW interface [polypeptide binding]; other site 936155007276 HMMPfam hit to PF00015, MCPsignal, score 1.5e-34 936155007277 2 probable transmembrane helices predicted for Hfelis16150 by TMHMM2.0 at aa 11-30 and 301-323 936155007278 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 936155007279 RNA/DNA hybrid binding site [nucleotide binding]; other site 936155007280 active site 936155007281 2 probable transmembrane helices predicted for Hfelis16170 by TMHMM2.0 at aa 5-27 and 42-61 936155007282 Uncharacterized conserved protein [Function unknown]; Region: COG4938 936155007283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936155007284 Walker A/P-loop; other site 936155007285 ATP binding site [chemical binding]; other site 936155007286 PS00017 ATP/GTP-binding site motif A (P-loop) 936155007287 Protein of unknown function DUF262; Region: DUF262; pfam03235 936155007288 HMMPfam hit to PF03235, DUF262, score 3.1e-07 936155007289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155007290 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 936155007291 HMMPfam hit to PF00534, Glycos_transf_1, score 1.1e-21 936155007292 Initiator Replication protein; Region: Rep_3; pfam01051 936155007293 HMMPfam hit to PF01051, Rep_3, score 4.3e-17 936155007294 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 936155007295 Sulfatase; Region: Sulfatase; pfam00884 936155007296 5 probable transmembrane helices predicted for Hfelis16310 by TMHMM2.0 at aa 7-26, 31-53, 66-88, 108-130 and 143-160 936155007297 HMMPfam hit to PF00884, Sulfatase, score 2e-51 936155007298 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 936155007299 HMMPfam hit to PF06306, CgtA, score 5.8e-82 936155007300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936155007301 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936155007302 HMMPfam hit to PF00534, Glycos_transf_1, score 9.4e-06 936155007303 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 936155007304 PS00485 Adenosine and AMP deaminase signature 936155007305 HMMPfam hit to PF01755, Glyco_transf_25, score 9.1e-30 936155007306 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 936155007307 Sulfatase; Region: Sulfatase; cl17466 936155007308 HMMPfam hit to PF00884, Sulfatase, score 6.9e-45 936155007309 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 936155007310 PLD-like domain; Region: PLDc_2; pfam13091 936155007311 putative active site [active] 936155007312 catalytic site [active] 936155007313 HMMPfam hit to PF00614, PLDc, score 1.5e-06 936155007314 3 probable transmembrane helices predicted for Hfelis16020 by TMHMM2.0 at aa 5-27, 37-59 and 71-93 936155007315 1 probable transmembrane helix predicted for Hfelis16030 by TMHMM2.0 at aa 7-29 936155007316 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936155007317 amidase catalytic site [active] 936155007318 Zn binding residues [ion binding]; other site 936155007319 substrate binding site [chemical binding]; other site 936155007320 HMMPfam hit to PF01510, Amidase_2, score 2.6e-09