-- dump date 20140619_112753 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869727000001 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 869727000002 putative RNA binding site [nucleotide binding]; other site 869727000003 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869727000004 homopentamer interface [polypeptide binding]; other site 869727000005 active site 869727000006 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869727000007 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 869727000008 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 869727000009 active site clefts [active] 869727000010 zinc binding site [ion binding]; other site 869727000011 dimer interface [polypeptide binding]; other site 869727000012 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869727000013 active site 869727000014 dimer interface [polypeptide binding]; other site 869727000015 pantoate--beta-alanine ligase; Region: panC; TIGR00018 869727000016 Pantoate-beta-alanine ligase; Region: PanC; cd00560 869727000017 active site 869727000018 ATP-binding site [chemical binding]; other site 869727000019 pantoate-binding site; other site 869727000020 HXXH motif; other site 869727000021 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000022 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869727000023 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869727000024 ring oligomerisation interface [polypeptide binding]; other site 869727000025 ATP/Mg binding site [chemical binding]; other site 869727000026 stacking interactions; other site 869727000027 hinge regions; other site 869727000028 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869727000029 oligomerisation interface [polypeptide binding]; other site 869727000030 mobile loop; other site 869727000031 roof hairpin; other site 869727000032 DNA primase, catalytic core; Region: dnaG; TIGR01391 869727000033 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869727000034 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869727000035 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869727000036 active site 869727000037 metal binding site [ion binding]; metal-binding site 869727000038 interdomain interaction site; other site 869727000039 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869727000040 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869727000041 Ligand Binding Site [chemical binding]; other site 869727000042 TrbC/VIRB2 family; Region: TrbC; cl01583 869727000043 potential frameshift: common BLAST hit: gi|15611086|ref|NP_222737.1| DNA transfer protein 869727000044 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 869727000045 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 869727000046 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727000047 Walker A motif; other site 869727000048 ATP binding site [chemical binding]; other site 869727000049 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727000050 Walker B motif; other site 869727000051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 869727000052 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 869727000053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869727000054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727000055 active site 869727000056 phosphorylation site [posttranslational modification] 869727000057 intermolecular recognition site; other site 869727000058 dimerization interface [polypeptide binding]; other site 869727000059 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869727000060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869727000061 dimer interface [polypeptide binding]; other site 869727000062 active site 869727000063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869727000064 catalytic residues [active] 869727000065 substrate binding site [chemical binding]; other site 869727000066 lipid A 1-phosphatase; Reviewed; Region: PRK09597 869727000067 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869727000068 active site 869727000069 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 869727000070 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 869727000071 Sulfatase; Region: Sulfatase; pfam00884 869727000072 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000073 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 869727000074 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 869727000075 dimer interface [polypeptide binding]; other site 869727000076 active site 869727000077 citrylCoA binding site [chemical binding]; other site 869727000078 NADH binding [chemical binding]; other site 869727000079 cationic pore residues; other site 869727000080 oxalacetate/citrate binding site [chemical binding]; other site 869727000081 coenzyme A binding site [chemical binding]; other site 869727000082 catalytic triad [active] 869727000083 isocitrate dehydrogenase; Validated; Region: PRK07362 869727000084 isocitrate dehydrogenase; Reviewed; Region: PRK07006 869727000085 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 869727000086 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 869727000087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869727000088 Ligand Binding Site [chemical binding]; other site 869727000089 Uncharacterized conserved protein [Function unknown]; Region: COG2127 869727000090 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869727000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727000092 Walker A motif; other site 869727000093 ATP binding site [chemical binding]; other site 869727000094 Walker B motif; other site 869727000095 arginine finger; other site 869727000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727000097 Walker A motif; other site 869727000098 ATP binding site [chemical binding]; other site 869727000099 Walker B motif; other site 869727000100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869727000101 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 869727000102 tetramerization interface [polypeptide binding]; other site 869727000103 active site 869727000104 hypothetical protein; Provisional; Region: PRK03762 869727000105 PDZ domain; Region: PDZ_2; pfam13180 869727000106 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 869727000107 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 869727000108 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 869727000109 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 869727000110 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 869727000111 VirB7 interaction site; other site 869727000112 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 869727000113 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 869727000114 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 869727000115 Substrate binding site; other site 869727000116 Cupin domain; Region: Cupin_2; cl17218 869727000117 potential frameshift: common BLAST hit: gi|15611109|ref|NP_222760.1| GDP-D-mannose dehydratase 869727000118 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 869727000119 NADP-binding site; other site 869727000120 homotetramer interface [polypeptide binding]; other site 869727000121 homodimer interface [polypeptide binding]; other site 869727000122 active site 869727000123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869727000124 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 869727000125 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 869727000126 NADP binding site [chemical binding]; other site 869727000127 active site 869727000128 putative substrate binding site [chemical binding]; other site 869727000129 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 869727000130 dimerization interface [polypeptide binding]; other site 869727000131 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 869727000132 ATP binding site [chemical binding]; other site 869727000133 Acylphosphatase; Region: Acylphosphatase; pfam00708 869727000134 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 869727000135 HypF finger; Region: zf-HYPF; pfam07503 869727000136 HypF finger; Region: zf-HYPF; pfam07503 869727000137 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 869727000138 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957 869727000139 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 869727000140 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869727000141 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727000142 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 869727000143 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869727000144 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 869727000145 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869727000146 cofactor binding site; other site 869727000147 DNA binding site [nucleotide binding] 869727000148 substrate interaction site [chemical binding]; other site 869727000149 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869727000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727000151 S-adenosylmethionine binding site [chemical binding]; other site 869727000152 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 869727000153 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 869727000154 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 869727000155 Na binding site [ion binding]; other site 869727000156 Proline dehydrogenase; Region: Pro_dh; pfam01619 869727000157 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 869727000158 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 869727000159 Glutamate binding site [chemical binding]; other site 869727000160 NAD binding site [chemical binding]; other site 869727000161 catalytic residues [active] 869727000162 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 869727000163 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869727000164 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 869727000165 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 869727000166 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869727000167 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869727000168 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 869727000169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 869727000170 G1 box; other site 869727000171 GTP/Mg2+ binding site [chemical binding]; other site 869727000172 G2 box; other site 869727000173 Switch I region; other site 869727000174 G3 box; other site 869727000175 Switch II region; other site 869727000176 G4 box; other site 869727000177 G5 box; other site 869727000178 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 869727000179 UreF; Region: UreF; pfam01730 869727000180 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 869727000181 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 869727000182 dimer interface [polypeptide binding]; other site 869727000183 catalytic residues [active] 869727000184 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 869727000185 urease subunit beta; Provisional; Region: ureB; PRK13985 869727000186 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 869727000187 subunit interactions [polypeptide binding]; other site 869727000188 active site 869727000189 flap region; other site 869727000190 urease subunit alpha; Provisional; Region: PRK13986 869727000191 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 869727000192 alpha-gamma subunit interface [polypeptide binding]; other site 869727000193 beta-gamma subunit interface [polypeptide binding]; other site 869727000194 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 869727000195 gamma-beta subunit interface [polypeptide binding]; other site 869727000196 alpha-beta subunit interface [polypeptide binding]; other site 869727000197 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 869727000198 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 869727000199 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869727000200 active site 869727000201 substrate binding site [chemical binding]; other site 869727000202 metal binding site [ion binding]; metal-binding site 869727000203 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869727000204 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869727000205 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869727000206 RF-1 domain; Region: RF-1; pfam00472 869727000207 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869727000209 dimer interface [polypeptide binding]; other site 869727000210 putative CheW interface [polypeptide binding]; other site 869727000211 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869727000212 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869727000213 23S rRNA interface [nucleotide binding]; other site 869727000214 L3 interface [polypeptide binding]; other site 869727000215 Predicted dehydrogenase [General function prediction only]; Region: COG0579 869727000216 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 869727000217 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 869727000218 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 869727000219 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 869727000220 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 869727000221 NlpC/P60 family; Region: NLPC_P60; pfam00877 869727000222 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 869727000223 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869727000224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869727000225 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869727000226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869727000227 DNA binding residues [nucleotide binding] 869727000228 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869727000229 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869727000230 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869727000231 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869727000232 Protein of unknown function (DUF511); Region: DUF511; pfam04373 869727000233 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869727000234 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727000235 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 869727000236 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 869727000237 GDP-Fucose binding site [chemical binding]; other site 869727000238 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 869727000239 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 869727000240 NAD binding site [chemical binding]; other site 869727000241 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869727000242 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869727000243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727000244 catalytic residue [active] 869727000245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869727000246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869727000247 dimer interface [polypeptide binding]; other site 869727000248 putative CheW interface [polypeptide binding]; other site 869727000249 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 869727000250 Ligand Binding Site [chemical binding]; other site 869727000251 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000252 putative glycosyl transferase; Provisional; Region: PRK10063 869727000253 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 869727000254 metal-binding site 869727000255 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 869727000256 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 869727000257 dimerization interface [polypeptide binding]; other site 869727000258 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869727000259 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869727000260 dimer interface [polypeptide binding]; other site 869727000261 putative CheW interface [polypeptide binding]; other site 869727000262 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869727000263 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 869727000264 active site 869727000265 metal binding site [ion binding]; metal-binding site 869727000266 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869727000267 S-ribosylhomocysteinase; Provisional; Region: PRK02260 869727000268 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 869727000269 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869727000270 homodimer interface [polypeptide binding]; other site 869727000271 substrate-cofactor binding pocket; other site 869727000272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727000273 catalytic residue [active] 869727000274 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869727000275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869727000276 dimer interface [polypeptide binding]; other site 869727000277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727000278 catalytic residue [active] 869727000279 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869727000280 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869727000281 nucleotide binding site [chemical binding]; other site 869727000282 NEF interaction site [polypeptide binding]; other site 869727000283 SBD interface [polypeptide binding]; other site 869727000284 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869727000285 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869727000286 dimer interface [polypeptide binding]; other site 869727000287 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869727000288 heat-inducible transcription repressor; Provisional; Region: PRK03911 869727000289 hypothetical protein; Provisional; Region: PRK05834 869727000290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 869727000291 flagellin B; Provisional; Region: PRK13588 869727000292 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869727000293 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869727000294 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869727000295 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869727000296 DNA topoisomerase I; Validated; Region: PRK05582 869727000297 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869727000298 active site 869727000299 interdomain interaction site; other site 869727000300 putative metal-binding site [ion binding]; other site 869727000301 nucleotide binding site [chemical binding]; other site 869727000302 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869727000303 domain I; other site 869727000304 DNA binding groove [nucleotide binding] 869727000305 phosphate binding site [ion binding]; other site 869727000306 domain II; other site 869727000307 domain III; other site 869727000308 nucleotide binding site [chemical binding]; other site 869727000309 catalytic site [active] 869727000310 domain IV; other site 869727000311 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869727000312 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869727000313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869727000314 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 869727000315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727000316 FeS/SAM binding site; other site 869727000317 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 869727000318 phosphoenolpyruvate synthase; Validated; Region: PRK06464 869727000319 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 869727000320 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869727000321 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869727000322 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 869727000323 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 869727000324 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869727000325 active site 869727000326 dimer interface [polypeptide binding]; other site 869727000327 motif 1; other site 869727000328 motif 2; other site 869727000329 motif 3; other site 869727000330 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869727000331 anticodon binding site; other site 869727000332 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869727000333 translation initiation factor IF-3; Region: infC; TIGR00168 869727000334 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869727000335 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869727000336 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869727000337 23S rRNA binding site [nucleotide binding]; other site 869727000338 L21 binding site [polypeptide binding]; other site 869727000339 L13 binding site [polypeptide binding]; other site 869727000340 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000341 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 869727000342 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 869727000343 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869727000344 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 869727000345 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869727000346 serine transporter; Region: stp; TIGR00814 869727000347 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 869727000348 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 869727000349 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 869727000350 catalytic triad [active] 869727000351 Uncharacterized conserved protein [Function unknown]; Region: COG1556 869727000352 iron-sulfur cluster-binding protein; Region: TIGR00273 869727000353 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 869727000354 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 869727000355 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 869727000356 Cysteine-rich domain; Region: CCG; pfam02754 869727000357 Cysteine-rich domain; Region: CCG; pfam02754 869727000358 L-lactate transport; Region: lctP; TIGR00795 869727000359 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 869727000360 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 869727000361 L-lactate transport; Region: lctP; TIGR00795 869727000362 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869727000363 DNA glycosylase MutY; Provisional; Region: PRK13910 869727000364 minor groove reading motif; other site 869727000365 helix-hairpin-helix signature motif; other site 869727000366 substrate binding pocket [chemical binding]; other site 869727000367 active site 869727000368 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869727000369 DNA binding and oxoG recognition site [nucleotide binding] 869727000370 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869727000371 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 869727000372 transmembrane helices; other site 869727000373 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 869727000374 Low-spin heme binding site [chemical binding]; other site 869727000375 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 869727000376 D-pathway; other site 869727000377 Putative water exit pathway; other site 869727000378 Binuclear center (active site) [active] 869727000379 K-pathway; other site 869727000380 Putative proton exit pathway; other site 869727000381 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 869727000382 cytochrome c oxidase, cbb3-type, subunit II; Region: ccoO; TIGR00781 869727000383 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 869727000384 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 869727000385 Cytochrome c; Region: Cytochrom_C; pfam00034 869727000386 Cytochrome c; Region: Cytochrom_C; pfam00034 869727000387 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 869727000388 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 869727000389 recombinase A; Provisional; Region: recA; PRK09354 869727000390 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869727000391 hexamer interface [polypeptide binding]; other site 869727000392 Walker A motif; other site 869727000393 ATP binding site [chemical binding]; other site 869727000394 Walker B motif; other site 869727000395 enolase; Provisional; Region: eno; PRK00077 869727000396 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869727000397 dimer interface [polypeptide binding]; other site 869727000398 metal binding site [ion binding]; metal-binding site 869727000399 substrate binding pocket [chemical binding]; other site 869727000400 AMIN domain; Region: AMIN; pfam11741 869727000401 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 869727000402 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869727000403 ADP binding site [chemical binding]; other site 869727000404 magnesium binding site [ion binding]; other site 869727000405 putative shikimate binding site; other site 869727000406 Cache domain; Region: Cache_1; pfam02743 869727000407 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727000408 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869727000409 Ligand binding site; other site 869727000410 metal-binding site 869727000411 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727000412 Sel1-like repeats; Region: SEL1; smart00671 869727000413 Sel1-like repeats; Region: SEL1; smart00671 869727000414 Sel1-like repeats; Region: SEL1; smart00671 869727000415 Sel1 repeat; Region: Sel1; cl02723 869727000416 Sel1-like repeats; Region: SEL1; smart00671 869727000417 Sel1-like repeats; Region: SEL1; smart00671 869727000418 hypothetical protein; Provisional; Region: PRK12378 869727000419 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 869727000420 dimer interface [polypeptide binding]; other site 869727000421 active site 869727000422 Schiff base residues; other site 869727000423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869727000424 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 869727000425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869727000426 dimer interface [polypeptide binding]; other site 869727000427 phosphorylation site [posttranslational modification] 869727000428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727000429 ATP binding site [chemical binding]; other site 869727000430 Mg2+ binding site [ion binding]; other site 869727000431 G-X-G motif; other site 869727000432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869727000433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727000434 active site 869727000435 phosphorylation site [posttranslational modification] 869727000436 intermolecular recognition site; other site 869727000437 dimerization interface [polypeptide binding]; other site 869727000438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869727000439 DNA binding site [nucleotide binding] 869727000440 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869727000441 Peptidase family U32; Region: Peptidase_U32; pfam01136 869727000442 peptide chain release factor 2; Region: prfB; TIGR00020 869727000443 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869727000444 RF-1 domain; Region: RF-1; pfam00472 869727000445 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 869727000446 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 869727000447 dimer interface [polypeptide binding]; other site 869727000448 putative functional site; other site 869727000449 putative MPT binding site; other site 869727000450 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 869727000451 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 869727000452 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 869727000453 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869727000454 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869727000455 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869727000456 intersubunit interface [polypeptide binding]; other site 869727000457 active site 869727000458 zinc binding site [ion binding]; other site 869727000459 Na+ binding site [ion binding]; other site 869727000460 elongation factor P; Validated; Region: PRK00529 869727000461 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869727000462 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869727000463 RNA binding site [nucleotide binding]; other site 869727000464 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869727000465 RNA binding site [nucleotide binding]; other site 869727000466 pseudaminic acid synthase; Region: PseI; TIGR03586 869727000467 NeuB family; Region: NeuB; pfam03102 869727000468 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 869727000469 NeuB binding interface [polypeptide binding]; other site 869727000470 putative substrate binding site [chemical binding]; other site 869727000471 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869727000472 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869727000473 Walker A/P-loop; other site 869727000474 ATP binding site [chemical binding]; other site 869727000475 Q-loop/lid; other site 869727000476 ABC transporter signature motif; other site 869727000477 Walker B; other site 869727000478 D-loop; other site 869727000479 H-loop/switch region; other site 869727000480 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 869727000481 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 869727000482 active site 869727000483 catalytic triad [active] 869727000484 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869727000485 Colicin V production protein; Region: Colicin_V; pfam02674 869727000486 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869727000487 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869727000488 dimer interface [polypeptide binding]; other site 869727000489 putative anticodon binding site; other site 869727000490 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869727000491 motif 1; other site 869727000492 active site 869727000493 motif 2; other site 869727000494 motif 3; other site 869727000495 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 869727000496 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869727000497 dimer interface [polypeptide binding]; other site 869727000498 active site 869727000499 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869727000500 folate binding site [chemical binding]; other site 869727000501 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 869727000502 nucleotide binding site [chemical binding]; other site 869727000503 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 869727000504 Sporulation related domain; Region: SPOR; cl10051 869727000505 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727000506 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727000507 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727000508 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 869727000509 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 869727000510 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 869727000511 putative active site [active] 869727000512 catalytic site [active] 869727000513 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 869727000514 putative active site [active] 869727000515 catalytic site [active] 869727000516 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 869727000517 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 869727000518 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869727000519 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 869727000520 L-aspartate oxidase; Provisional; Region: PRK06175 869727000521 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869727000522 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 869727000523 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 869727000524 Iron-sulfur protein interface; other site 869727000525 proximal heme binding site [chemical binding]; other site 869727000526 distal heme binding site [chemical binding]; other site 869727000527 dimer interface [polypeptide binding]; other site 869727000528 triosephosphate isomerase; Provisional; Region: PRK14567 869727000529 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869727000530 substrate binding site [chemical binding]; other site 869727000531 dimer interface [polypeptide binding]; other site 869727000532 catalytic triad [active] 869727000533 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 869727000534 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 869727000535 NAD binding site [chemical binding]; other site 869727000536 homotetramer interface [polypeptide binding]; other site 869727000537 homodimer interface [polypeptide binding]; other site 869727000538 substrate binding site [chemical binding]; other site 869727000539 active site 869727000540 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 869727000541 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 869727000542 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 869727000543 trimer interface [polypeptide binding]; other site 869727000544 active site 869727000545 UDP-GlcNAc binding site [chemical binding]; other site 869727000546 lipid binding site [chemical binding]; lipid-binding site 869727000547 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869727000548 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869727000549 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869727000550 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869727000551 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869727000552 active site 869727000553 multimer interface [polypeptide binding]; other site 869727000554 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 869727000555 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 869727000556 fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182 869727000557 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 869727000558 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869727000559 dimer interface [polypeptide binding]; other site 869727000560 active site 869727000561 CoA binding pocket [chemical binding]; other site 869727000562 AAA ATPase domain; Region: AAA_15; pfam13175 869727000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869727000564 Walker B; other site 869727000565 D-loop; other site 869727000566 H-loop/switch region; other site 869727000567 antiporter inner membrane protein; Provisional; Region: PRK11670 869727000568 Domain of unknown function DUF59; Region: DUF59; pfam01883 869727000569 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 869727000570 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727000571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869727000572 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727000573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869727000574 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727000575 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727000576 heat shock protein 90; Provisional; Region: PRK05218 869727000577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727000578 ATP binding site [chemical binding]; other site 869727000579 Mg2+ binding site [ion binding]; other site 869727000580 G-X-G motif; other site 869727000581 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727000582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727000583 binding surface 869727000584 TPR motif; other site 869727000585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727000586 TPR motif; other site 869727000587 binding surface 869727000588 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 869727000589 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 869727000590 metal binding site [ion binding]; metal-binding site 869727000591 dimer interface [polypeptide binding]; other site 869727000592 glucose-inhibited division protein A; Region: gidA; TIGR00136 869727000593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869727000594 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 869727000595 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869727000596 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869727000597 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 869727000598 transmembrane helices; other site 869727000599 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869727000600 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869727000601 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 869727000602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 869727000603 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 869727000604 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 869727000605 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 869727000606 substrate binding site [chemical binding]; other site 869727000607 Helix-turn-helix domain; Region: HTH_28; pfam13518 869727000608 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 869727000609 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869727000610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869727000611 catalytic residue [active] 869727000612 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 869727000613 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869727000614 trimerization site [polypeptide binding]; other site 869727000615 active site 869727000616 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869727000617 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 869727000618 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869727000619 DNA repair protein RadA; Region: sms; TIGR00416 869727000620 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 869727000621 Walker A motif/ATP binding site; other site 869727000622 ATP binding site [chemical binding]; other site 869727000623 Walker B motif; other site 869727000624 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869727000625 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869727000626 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869727000627 SelR domain; Region: SelR; pfam01641 869727000628 Predicted permeases [General function prediction only]; Region: COG0730 869727000629 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 869727000630 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 869727000631 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869727000632 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000633 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 869727000634 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 869727000635 Ligand binding site; other site 869727000636 oligomer interface; other site 869727000637 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 869727000638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869727000639 hypothetical protein; Provisional; Region: PRK04081 869727000640 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 869727000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 869727000642 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727000643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727000644 binding surface 869727000645 TPR motif; other site 869727000646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869727000647 binding surface 869727000648 TPR motif; other site 869727000649 Sel1-like repeats; Region: SEL1; smart00671 869727000650 Sel1-like repeats; Region: SEL1; smart00671 869727000651 Cytochrome c; Region: Cytochrom_C; cl11414 869727000652 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 869727000653 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 869727000654 domain interfaces; other site 869727000655 active site 869727000656 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869727000657 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869727000658 dimer interface [polypeptide binding]; other site 869727000659 motif 1; other site 869727000660 active site 869727000661 motif 2; other site 869727000662 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869727000663 putative deacylase active site [active] 869727000664 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869727000665 active site 869727000666 motif 3; other site 869727000667 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869727000668 anticodon binding site; other site 869727000669 glutamyl-tRNA reductase; Region: hemA; TIGR01035 869727000670 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 869727000671 tRNA; other site 869727000672 putative tRNA binding site [nucleotide binding]; other site 869727000673 putative NADP binding site [chemical binding]; other site 869727000674 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 869727000675 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869727000676 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869727000677 substrate binding pocket [chemical binding]; other site 869727000678 chain length determination region; other site 869727000679 substrate-Mg2+ binding site; other site 869727000680 catalytic residues [active] 869727000681 aspartate-rich region 1; other site 869727000682 active site lid residues [active] 869727000683 aspartate-rich region 2; other site 869727000684 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 869727000685 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869727000686 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869727000687 dimerization interface [polypeptide binding]; other site 869727000688 DPS ferroxidase diiron center [ion binding]; other site 869727000689 ion pore; other site 869727000690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869727000691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869727000692 dimer interface [polypeptide binding]; other site 869727000693 phosphorylation site [posttranslational modification] 869727000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727000695 ATP binding site [chemical binding]; other site 869727000696 Mg2+ binding site [ion binding]; other site 869727000697 G-X-G motif; other site 869727000698 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 869727000699 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 869727000700 helicase 45; Provisional; Region: PTZ00424 869727000701 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869727000702 ATP binding site [chemical binding]; other site 869727000703 Mg++ binding site [ion binding]; other site 869727000704 motif III; other site 869727000705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727000706 nucleotide binding region [chemical binding]; other site 869727000707 ATP-binding site [chemical binding]; other site 869727000708 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869727000709 SPFH domain / Band 7 family; Region: Band_7; pfam01145 869727000710 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 869727000711 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 869727000712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869727000713 Walker A/P-loop; other site 869727000714 ATP binding site [chemical binding]; other site 869727000715 Q-loop/lid; other site 869727000716 ABC transporter signature motif; other site 869727000717 Walker B; other site 869727000718 D-loop; other site 869727000719 H-loop/switch region; other site 869727000720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869727000721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869727000722 Walker A/P-loop; other site 869727000723 ATP binding site [chemical binding]; other site 869727000724 Q-loop/lid; other site 869727000725 ABC transporter signature motif; other site 869727000726 Walker B; other site 869727000727 D-loop; other site 869727000728 H-loop/switch region; other site 869727000729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869727000730 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 869727000731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727000732 dimer interface [polypeptide binding]; other site 869727000733 conserved gate region; other site 869727000734 putative PBP binding loops; other site 869727000735 ABC-ATPase subunit interface; other site 869727000736 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000737 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000738 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869727000739 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869727000740 GDP-binding site [chemical binding]; other site 869727000741 ACT binding site; other site 869727000742 IMP binding site; other site 869727000743 Flagellar FliJ protein; Region: FliJ; pfam02050 869727000744 Uncharacterized conserved protein [Function unknown]; Region: COG3334 869727000745 RIP metalloprotease RseP; Region: TIGR00054 869727000746 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869727000747 active site 869727000748 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 869727000749 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869727000750 putative substrate binding region [chemical binding]; other site 869727000751 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 869727000752 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869727000753 generic binding surface II; other site 869727000754 generic binding surface I; other site 869727000755 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727000756 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727000757 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727000758 potential frameshift: common BLAST hit: gi|208434208|ref|YP_002265874.1| type II DNA modification enzyme 869727000759 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869727000760 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727000761 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 869727000762 Clp amino terminal domain; Region: Clp_N; pfam02861 869727000763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727000764 Walker A motif; other site 869727000765 ATP binding site [chemical binding]; other site 869727000766 Walker B motif; other site 869727000767 arginine finger; other site 869727000768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727000769 Walker A motif; other site 869727000770 ATP binding site [chemical binding]; other site 869727000771 Walker B motif; other site 869727000772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869727000773 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869727000774 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 869727000775 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 869727000776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869727000777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869727000778 active site 869727000779 chlorohydrolase; Provisional; Region: PRK08418 869727000780 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 869727000781 active site 869727000782 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869727000783 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 869727000784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727000785 FeS/SAM binding site; other site 869727000786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 869727000787 putative acyl-acceptor binding pocket; other site 869727000788 urocanate hydratase; Provisional; Region: PRK05414 869727000789 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 869727000790 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 869727000791 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 869727000792 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 869727000793 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869727000794 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869727000795 putative active site [active] 869727000796 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 869727000797 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 869727000798 putative acyl-acceptor binding pocket; other site 869727000799 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869727000800 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 869727000801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 869727000802 TrkA-C domain; Region: TrkA_C; pfam02080 869727000803 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869727000804 active site 869727000805 dimer interface [polypeptide binding]; other site 869727000806 metal binding site [ion binding]; metal-binding site 869727000807 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869727000808 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869727000809 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 869727000810 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869727000811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727000812 FeS/SAM binding site; other site 869727000813 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 869727000814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727000815 Walker B motif; other site 869727000816 arginine finger; other site 869727000817 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 869727000818 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727000819 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727000820 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 869727000821 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727000822 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869727000823 diaminopimelate decarboxylase; Region: lysA; TIGR01048 869727000824 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869727000825 active site 869727000826 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869727000827 substrate binding site [chemical binding]; other site 869727000828 catalytic residues [active] 869727000829 dimer interface [polypeptide binding]; other site 869727000830 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 869727000831 Uncharacterized conserved protein [Function unknown]; Region: COG4866 869727000832 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869727000833 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869727000834 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 869727000835 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869727000836 substrate-cofactor binding pocket; other site 869727000837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727000838 catalytic residue [active] 869727000839 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 869727000840 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 869727000841 multimer interface [polypeptide binding]; other site 869727000842 active site 869727000843 catalytic triad [active] 869727000844 dimer interface [polypeptide binding]; other site 869727000845 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 869727000846 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869727000847 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869727000848 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869727000849 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869727000850 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 869727000851 peptide binding site [polypeptide binding]; other site 869727000852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869727000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727000854 dimer interface [polypeptide binding]; other site 869727000855 conserved gate region; other site 869727000856 putative PBP binding loops; other site 869727000857 ABC-ATPase subunit interface; other site 869727000858 dipeptide transporter; Provisional; Region: PRK10913 869727000859 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869727000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727000861 dimer interface [polypeptide binding]; other site 869727000862 conserved gate region; other site 869727000863 putative PBP binding loops; other site 869727000864 ABC-ATPase subunit interface; other site 869727000865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869727000866 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 869727000867 Walker A/P-loop; other site 869727000868 ATP binding site [chemical binding]; other site 869727000869 Q-loop/lid; other site 869727000870 ABC transporter signature motif; other site 869727000871 Walker B; other site 869727000872 D-loop; other site 869727000873 H-loop/switch region; other site 869727000874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869727000875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869727000876 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869727000877 Walker A/P-loop; other site 869727000878 ATP binding site [chemical binding]; other site 869727000879 Q-loop/lid; other site 869727000880 ABC transporter signature motif; other site 869727000881 Walker B; other site 869727000882 D-loop; other site 869727000883 H-loop/switch region; other site 869727000884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869727000885 GTPase CgtA; Reviewed; Region: obgE; PRK12299 869727000886 GTP1/OBG; Region: GTP1_OBG; pfam01018 869727000887 Obg GTPase; Region: Obg; cd01898 869727000888 G1 box; other site 869727000889 GTP/Mg2+ binding site [chemical binding]; other site 869727000890 Switch I region; other site 869727000891 G2 box; other site 869727000892 G3 box; other site 869727000893 Switch II region; other site 869727000894 G4 box; other site 869727000895 G5 box; other site 869727000896 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 869727000897 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869727000898 inhibitor-cofactor binding pocket; inhibition site 869727000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727000900 catalytic residue [active] 869727000901 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 869727000902 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869727000903 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 869727000904 active site 869727000905 catalytic triad [active] 869727000906 dimer interface [polypeptide binding]; other site 869727000907 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 869727000908 active site 869727000909 catalytic site [active] 869727000910 Zn binding site [ion binding]; other site 869727000911 tetramer interface [polypeptide binding]; other site 869727000912 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869727000913 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 869727000914 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 869727000915 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 869727000916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727000917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869727000918 putative substrate translocation pore; other site 869727000919 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869727000920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727000921 Walker A/P-loop; other site 869727000922 ATP binding site [chemical binding]; other site 869727000923 Q-loop/lid; other site 869727000924 ABC transporter signature motif; other site 869727000925 Walker B; other site 869727000926 D-loop; other site 869727000927 H-loop/switch region; other site 869727000928 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 869727000929 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 869727000930 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 869727000931 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 869727000932 arginyl-tRNA synthetase; Region: argS; TIGR00456 869727000933 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869727000934 active site 869727000935 HIGH motif; other site 869727000936 KMSK motif region; other site 869727000937 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869727000938 tRNA binding surface [nucleotide binding]; other site 869727000939 anticodon binding site; other site 869727000940 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 869727000941 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869727000942 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869727000943 catalytic site [active] 869727000944 G-X2-G-X-G-K; other site 869727000945 potential frameshift: common BLAST hit: gi|210134517|ref|YP_002300956.1| poly E-rich protein 869727000946 nuclease NucT; Provisional; Region: PRK13912 869727000947 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 869727000948 putative active site [active] 869727000949 catalytic site [active] 869727000950 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727000951 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 869727000952 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 869727000953 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 869727000954 ligand binding site; other site 869727000955 tetramer interface; other site 869727000956 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 869727000957 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 869727000958 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869727000959 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 869727000960 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 869727000961 NAD synthetase; Provisional; Region: PRK13980 869727000962 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869727000963 homodimer interface [polypeptide binding]; other site 869727000964 NAD binding pocket [chemical binding]; other site 869727000965 ATP binding pocket [chemical binding]; other site 869727000966 Mg binding site [ion binding]; other site 869727000967 active-site loop [active] 869727000968 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869727000969 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869727000970 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869727000971 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 869727000972 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 869727000973 Switch I; other site 869727000974 Switch II; other site 869727000975 cell division topological specificity factor MinE; Region: minE; TIGR01215 869727000976 DNA protecting protein DprA; Region: dprA; TIGR00732 869727000977 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 869727000978 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869727000979 Sel1 repeat; Region: Sel1; cl02723 869727000980 potential frameshift: common BLAST hit: gi|210134539|ref|YP_002300978.1| pseudouridine synthase D 869727000981 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869727000982 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 869727000983 active site 869727000984 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869727000985 DHH family; Region: DHH; pfam01368 869727000986 DHHA1 domain; Region: DHHA1; pfam02272 869727000987 CTP synthetase; Validated; Region: pyrG; PRK05380 869727000988 CTP synthase N-terminus; Region: CTP_synth_N; pfam06418 869727000989 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869727000990 active site 869727000991 putative oxyanion hole; other site 869727000992 catalytic triad [active] 869727000993 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 869727000994 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 869727000995 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 869727000996 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 869727000997 flagellar motor switch protein FliG; Region: fliG; TIGR00207 869727000998 FliG C-terminal domain; Region: FliG_C; pfam01706 869727000999 flagellar assembly protein H; Validated; Region: fliH; PRK06669 869727001000 Flagellar assembly protein FliH; Region: FliH; pfam02108 869727001001 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 869727001002 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 869727001003 TPP-binding site; other site 869727001004 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869727001005 PYR/PP interface [polypeptide binding]; other site 869727001006 dimer interface [polypeptide binding]; other site 869727001007 TPP binding site [chemical binding]; other site 869727001008 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869727001009 GTP-binding protein LepA; Provisional; Region: PRK05433 869727001010 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869727001011 G1 box; other site 869727001012 putative GEF interaction site [polypeptide binding]; other site 869727001013 GTP/Mg2+ binding site [chemical binding]; other site 869727001014 Switch I region; other site 869727001015 G2 box; other site 869727001016 G3 box; other site 869727001017 Switch II region; other site 869727001018 G4 box; other site 869727001019 G5 box; other site 869727001020 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 869727001021 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869727001022 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869727001023 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 869727001024 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 869727001025 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 869727001026 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 869727001027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727001029 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869727001030 TspO/MBR family; Region: TspO_MBR; cl01379 869727001031 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869727001032 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869727001033 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 869727001034 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 869727001035 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 869727001036 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869727001037 TPP-binding site [chemical binding]; other site 869727001038 dimer interface [polypeptide binding]; other site 869727001039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869727001040 PYR/PP interface [polypeptide binding]; other site 869727001041 dimer interface [polypeptide binding]; other site 869727001042 TPP binding site [chemical binding]; other site 869727001043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869727001044 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869727001045 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 869727001046 active site 869727001047 Riboflavin kinase; Region: Flavokinase; pfam01687 869727001048 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869727001049 S4 RNA-binding domain; Region: S4; smart00363 869727001050 RNA binding surface [nucleotide binding]; other site 869727001051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727001052 S-adenosylmethionine binding site [chemical binding]; other site 869727001053 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869727001054 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869727001055 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869727001056 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727001057 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727001058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869727001059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869727001060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727001061 Walker A/P-loop; other site 869727001062 ATP binding site [chemical binding]; other site 869727001063 Q-loop/lid; other site 869727001064 ABC transporter signature motif; other site 869727001065 Walker B; other site 869727001066 D-loop; other site 869727001067 H-loop/switch region; other site 869727001068 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 869727001069 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787 869727001070 Restriction endonuclease; Region: Mrr_cat; pfam04471 869727001071 Predicted ATPases [General function prediction only]; Region: COG1106 869727001072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727001073 Walker A/P-loop; other site 869727001074 ATP binding site [chemical binding]; other site 869727001075 Predicted ATPases [General function prediction only]; Region: COG1106 869727001076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727001077 Walker B; other site 869727001078 D-loop; other site 869727001079 H-loop/switch region; other site 869727001080 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 869727001081 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 869727001082 active site 869727001083 Zn binding site [ion binding]; other site 869727001084 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869727001085 metal-binding site [ion binding] 869727001086 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869727001087 metal-binding site [ion binding] 869727001088 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 869727001089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869727001090 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869727001091 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 869727001092 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 869727001093 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 869727001094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001095 Walker A motif; other site 869727001096 ATP binding site [chemical binding]; other site 869727001097 Walker B motif; other site 869727001098 arginine finger; other site 869727001099 Peptidase family M41; Region: Peptidase_M41; pfam01434 869727001100 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 869727001101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727001102 S-adenosylmethionine binding site [chemical binding]; other site 869727001103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727001104 Response regulator receiver domain; Region: Response_reg; pfam00072 869727001105 active site 869727001106 phosphorylation site [posttranslational modification] 869727001107 intermolecular recognition site; other site 869727001108 dimerization interface [polypeptide binding]; other site 869727001109 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001110 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 869727001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727001112 S-adenosylmethionine binding site [chemical binding]; other site 869727001113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869727001114 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869727001115 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 869727001116 sec-independent translocase; Provisional; Region: PRK04098 869727001117 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869727001118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001119 Walker A motif; other site 869727001120 ATP binding site [chemical binding]; other site 869727001121 Walker B motif; other site 869727001122 arginine finger; other site 869727001123 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869727001124 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 869727001125 oligomerization interface [polypeptide binding]; other site 869727001126 active site 869727001127 metal binding site [ion binding]; metal-binding site 869727001128 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001129 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001130 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869727001131 septum formation inhibitor; Reviewed; Region: minC; PRK00556 869727001132 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 869727001133 UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325 869727001134 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 869727001135 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 869727001136 homoserine kinase; Region: thrB; TIGR00191 869727001137 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869727001138 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 869727001139 putative RNA binding cleft [nucleotide binding]; other site 869727001140 translation initiation factor IF-2; Region: IF-2; TIGR00487 869727001141 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869727001142 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869727001143 G1 box; other site 869727001144 putative GEF interaction site [polypeptide binding]; other site 869727001145 GTP/Mg2+ binding site [chemical binding]; other site 869727001146 Switch I region; other site 869727001147 G2 box; other site 869727001148 G3 box; other site 869727001149 Switch II region; other site 869727001150 G4 box; other site 869727001151 G5 box; other site 869727001152 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869727001153 Translation-initiation factor 2; Region: IF-2; pfam11987 869727001154 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869727001155 ribosome-binding factor A; Region: rbfA; TIGR00082 869727001156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 869727001157 Sm and related proteins; Region: Sm_like; cl00259 869727001158 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869727001159 putative oligomer interface [polypeptide binding]; other site 869727001160 putative RNA binding site [nucleotide binding]; other site 869727001161 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 869727001162 putative active site [active] 869727001163 putative metal binding site [ion binding]; other site 869727001164 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869727001165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869727001166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727001167 active site 869727001168 intermolecular recognition site; other site 869727001169 dimerization interface [polypeptide binding]; other site 869727001170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869727001171 DNA binding site [nucleotide binding] 869727001172 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 869727001173 DHH family; Region: DHH; pfam01368 869727001174 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 869727001175 FHIPEP family; Region: FHIPEP; pfam00771 869727001176 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869727001177 16S/18S rRNA binding site [nucleotide binding]; other site 869727001178 S13e-L30e interaction site [polypeptide binding]; other site 869727001179 25S rRNA binding site [nucleotide binding]; other site 869727001180 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 869727001181 O-Antigen ligase; Region: Wzy_C; pfam04932 869727001182 Dehydroquinase class II; Region: DHquinase_II; pfam01220 869727001183 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 869727001184 trimer interface [polypeptide binding]; other site 869727001185 active site 869727001186 dimer interface [polypeptide binding]; other site 869727001187 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869727001188 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869727001189 active site 869727001190 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869727001191 catalytic center binding site [active] 869727001192 ATP binding site [chemical binding]; other site 869727001193 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 869727001194 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869727001195 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 869727001196 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869727001197 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 869727001198 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 869727001199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869727001200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869727001201 DNA binding residues [nucleotide binding] 869727001202 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 869727001203 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 869727001204 flagellar motor switch protein FliY; Validated; Region: PRK08432 869727001205 flagellar motor switch protein FliN; Region: fliN; TIGR02480 869727001206 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 869727001207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 869727001208 ferric uptake regulator; Provisional; Region: fur; PRK09462 869727001209 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869727001210 metal binding site 2 [ion binding]; metal-binding site 869727001211 putative DNA binding helix; other site 869727001212 metal binding site 1 [ion binding]; metal-binding site 869727001213 dimer interface [polypeptide binding]; other site 869727001214 structural Zn2+ binding site [ion binding]; other site 869727001215 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 869727001216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001217 Walker A motif; other site 869727001218 ATP binding site [chemical binding]; other site 869727001219 Walker B motif; other site 869727001220 arginine finger; other site 869727001221 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869727001222 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 869727001223 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869727001224 DNA binding residues [nucleotide binding] 869727001225 putative dimer interface [polypeptide binding]; other site 869727001226 chaperone protein DnaJ; Provisional; Region: PRK14299 869727001227 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869727001228 HSP70 interaction site [polypeptide binding]; other site 869727001229 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869727001230 substrate binding site [polypeptide binding]; other site 869727001231 dimer interface [polypeptide binding]; other site 869727001232 5'-3' exonuclease; Provisional; Region: PRK14976 869727001233 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 869727001234 putative active site [active] 869727001235 Helix-hairpin-helix class 2 (Pol1 family) motifs; Region: HhH2; smart00279 869727001236 DNA binding site [nucleotide binding] 869727001237 metal binding site [ion binding]; metal-binding site 869727001238 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869727001239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727001240 active site 869727001241 dimerization interface [polypeptide binding]; other site 869727001242 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 869727001243 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869727001244 substrate binding site; other site 869727001245 dimer interface; other site 869727001246 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 869727001247 homotrimer interaction site [polypeptide binding]; other site 869727001248 zinc binding site [ion binding]; other site 869727001249 CDP-binding sites; other site 869727001250 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 869727001251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869727001252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869727001253 protein binding site [polypeptide binding]; other site 869727001254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869727001255 S-methylmethionine transporter; Provisional; Region: PRK11387 869727001256 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 869727001257 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 869727001258 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 869727001259 putative NAD(P) binding site [chemical binding]; other site 869727001260 active site 869727001261 dihydrodipicolinate synthase; Region: dapA; TIGR00674 869727001262 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869727001263 dimer interface [polypeptide binding]; other site 869727001264 active site 869727001265 catalytic residue [active] 869727001266 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869727001267 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869727001268 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869727001269 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 869727001270 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 869727001271 quinone interaction residues [chemical binding]; other site 869727001272 active site 869727001273 catalytic residues [active] 869727001274 FMN binding site [chemical binding]; other site 869727001275 substrate binding site [chemical binding]; other site 869727001276 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 869727001277 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 869727001278 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 869727001279 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 869727001280 putative domain interface [polypeptide binding]; other site 869727001281 putative active site [active] 869727001282 catalytic site [active] 869727001283 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 869727001284 putative active site [active] 869727001285 putative domain interface [polypeptide binding]; other site 869727001286 catalytic site [active] 869727001287 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869727001288 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869727001289 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869727001290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727001291 S-adenosylmethionine binding site [chemical binding]; other site 869727001292 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 869727001293 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 869727001294 ATP binding site [chemical binding]; other site 869727001295 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 869727001296 putative Mg++ binding site [ion binding]; other site 869727001297 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 869727001298 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869727001299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 869727001300 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 869727001301 putative metal binding site [ion binding]; other site 869727001302 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 869727001303 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 869727001304 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 869727001305 active site 869727001306 Zn binding site [ion binding]; other site 869727001307 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 869727001308 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 869727001309 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001310 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869727001311 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 869727001312 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869727001313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727001314 dimer interface [polypeptide binding]; other site 869727001315 conserved gate region; other site 869727001316 putative PBP binding loops; other site 869727001317 ABC-ATPase subunit interface; other site 869727001318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727001319 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869727001320 Walker A/P-loop; other site 869727001321 ATP binding site [chemical binding]; other site 869727001322 Q-loop/lid; other site 869727001323 ABC transporter signature motif; other site 869727001324 Walker B; other site 869727001325 D-loop; other site 869727001326 H-loop/switch region; other site 869727001327 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869727001328 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869727001329 active site 869727001330 HIGH motif; other site 869727001331 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869727001332 active site 869727001333 KMSKS motif; other site 869727001334 potential frameshift: common BLAST hit: gi|15611497|ref|NP_223148.1| type II DNA modification (methyltransferase 869727001335 Helix-turn-helix domain; Region: HTH_17; pfam12728 869727001336 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869727001337 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869727001338 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 869727001339 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869727001340 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 869727001341 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869727001342 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869727001343 G1 box; other site 869727001344 putative GEF interaction site [polypeptide binding]; other site 869727001345 GTP/Mg2+ binding site [chemical binding]; other site 869727001346 Switch I region; other site 869727001347 G2 box; other site 869727001348 G3 box; other site 869727001349 Switch II region; other site 869727001350 G4 box; other site 869727001351 G5 box; other site 869727001352 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869727001353 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869727001354 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 869727001355 potential frameshift: common BLAST hit: gi|308184263|ref|YP_003928396.1| type II restriction endonuclease 869727001356 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 869727001357 GIY-YIG motif/motif A; other site 869727001358 active site 869727001359 catalytic site [active] 869727001360 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 869727001361 catalytic site [active] 869727001362 metal binding site [ion binding]; metal-binding site 869727001363 potential frameshift: common BLAST hit: gi|15611502|ref|NP_223153.1| type II DNA modification (methyltransferase 869727001364 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 869727001365 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869727001366 cofactor binding site; other site 869727001367 DNA binding site [nucleotide binding] 869727001368 substrate interaction site [chemical binding]; other site 869727001369 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 869727001370 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869727001371 potential frameshift: common BLAST hit: gi|254779149|ref|YP_003057254.1| non-functional type II restriction endonuclease 869727001372 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 869727001373 putative heme binding pocket [chemical binding]; other site 869727001374 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727001375 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727001376 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 869727001377 TrkA-N domain; Region: TrkA_N; pfam02254 869727001378 TrkA-C domain; Region: TrkA_C; pfam02080 869727001379 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869727001380 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 869727001381 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 869727001382 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869727001383 Mg++ binding site [ion binding]; other site 869727001384 putative catalytic motif [active] 869727001385 putative substrate binding site [chemical binding]; other site 869727001386 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 869727001387 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869727001388 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869727001389 Protein of unknown function (DUF493); Region: DUF493; pfam04359 869727001390 potential frameshift: common BLAST hit: gi|254779482|ref|YP_003057587.1| thioesterase 869727001391 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 869727001392 active site 2 [active] 869727001393 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869727001394 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 869727001395 Na2 binding site [ion binding]; other site 869727001396 putative substrate binding site 1 [chemical binding]; other site 869727001397 Na binding site 1 [ion binding]; other site 869727001398 putative substrate binding site 2 [chemical binding]; other site 869727001399 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 869727001400 Na2 binding site [ion binding]; other site 869727001401 putative substrate binding site 1 [chemical binding]; other site 869727001402 Na binding site 1 [ion binding]; other site 869727001403 putative substrate binding site 2 [chemical binding]; other site 869727001404 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 869727001405 dimerization interface [polypeptide binding]; other site 869727001406 substrate binding site [chemical binding]; other site 869727001407 active site 869727001408 calcium binding site [ion binding]; other site 869727001409 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 869727001410 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869727001411 putative DNA binding surface [nucleotide binding]; other site 869727001412 dimer interface [polypeptide binding]; other site 869727001413 beta-clamp/translesion DNA polymerase binding surface; other site 869727001414 beta-clamp/clamp loader binding surface; other site 869727001415 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 869727001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727001417 Mg2+ binding site [ion binding]; other site 869727001418 G-X-G motif; other site 869727001419 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869727001420 anchoring element; other site 869727001421 dimer interface [polypeptide binding]; other site 869727001422 ATP binding site [chemical binding]; other site 869727001423 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869727001424 active site 869727001425 putative metal-binding site [ion binding]; other site 869727001426 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869727001427 R.Pab1 restriction endonuclease; Region: RE_R_Pab1; pfam09522 869727001428 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869727001429 Peptidase family M23; Region: Peptidase_M23; pfam01551 869727001430 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 869727001431 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869727001432 dimer interface [polypeptide binding]; other site 869727001433 ADP-ribose binding site [chemical binding]; other site 869727001434 active site 869727001435 nudix motif; other site 869727001436 metal binding site [ion binding]; metal-binding site 869727001437 FAD binding domain; Region: FAD_binding_4; pfam01565 869727001438 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 869727001439 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 869727001440 dihydrodipicolinate reductase; Region: dapB; TIGR00036 869727001441 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869727001442 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869727001443 glutamine synthetase, type I; Region: GlnA; TIGR00653 869727001444 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869727001445 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869727001446 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727001447 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727001448 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727001449 Uncharacterized conserved protein [Function unknown]; Region: COG3586 869727001450 ribosomal protein L9; Region: L9; TIGR00158 869727001451 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869727001452 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869727001453 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 869727001454 active site 869727001455 HslU subunit interaction site [polypeptide binding]; other site 869727001456 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 869727001457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001458 Walker A motif; other site 869727001459 ATP binding site [chemical binding]; other site 869727001460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001461 Walker B motif; other site 869727001462 arginine finger; other site 869727001463 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869727001464 GTPase [General function prediction only]; Region: Era; COG1159 869727001465 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869727001466 G1 box; other site 869727001467 GTP/Mg2+ binding site [chemical binding]; other site 869727001468 Switch I region; other site 869727001469 G2 box; other site 869727001470 Switch II region; other site 869727001471 G3 box; other site 869727001472 G4 box; other site 869727001473 G5 box; other site 869727001474 KH domain; Region: KH_2; pfam07650 869727001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 869727001476 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727001477 Sel1-like repeats; Region: SEL1; smart00671 869727001478 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 869727001479 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 869727001480 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 869727001481 Walker A motif; other site 869727001482 ATP binding site [chemical binding]; other site 869727001483 Walker B motif; other site 869727001484 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 869727001485 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 869727001486 ATP binding site [chemical binding]; other site 869727001487 Walker A motif; other site 869727001488 hexamer interface [polypeptide binding]; other site 869727001489 Walker B motif; other site 869727001490 CagZ; Region: CagZ; pfam09053 869727001491 potential frameshift: common BLAST hit: gi|308184310|ref|YP_003928443.1| cag island protein 869727001492 DC-EC Repeat; Region: CagY_M; pfam07337 869727001493 DC-EC Repeat; Region: CagY_M; pfam07337 869727001494 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 869727001495 potential frameshift: common BLAST hit: gi|383749812|ref|YP_005424915.1| cag pathogenicity island protein (cag7) 869727001496 potential frameshift: common BLAST hit: gi|383749812|ref|YP_005424915.1| cag pathogenicity island protein (cag7) 869727001497 DC-EC Repeat; Region: CagY_M; pfam07337 869727001498 DC-EC Repeat; Region: CagY_M; pfam07337 869727001499 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 869727001500 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 869727001501 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 869727001502 VirB7 interaction site; other site 869727001503 potential frameshift: common BLAST hit: gi|308184308|ref|YP_003928441.1| cag pathogenicity island protein W 869727001504 Niemann-Pick C type protein family; Region: 2A060601; TIGR00917 869727001505 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 869727001506 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 869727001507 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 869727001508 prolyl-tRNA synthetase; Provisional; Region: PRK08661 869727001509 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 869727001510 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 869727001511 CagA exotoxin; Region: CagA; pfam03507 869727001512 CagA exotoxin; Region: CagA; pfam03507 869727001513 AAA domain; Region: AAA_12; pfam13087 869727001514 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 869727001515 transcription termination factor Rho; Provisional; Region: rho; PRK09376 869727001516 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 869727001517 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 869727001518 RNA binding site [nucleotide binding]; other site 869727001519 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 869727001520 multimer interface [polypeptide binding]; other site 869727001521 Walker A motif; other site 869727001522 ATP binding site [chemical binding]; other site 869727001523 Walker B motif; other site 869727001524 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 869727001525 Predicted methyltransferases [General function prediction only]; Region: COG0313 869727001526 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869727001527 putative SAM binding site [chemical binding]; other site 869727001528 putative homodimer interface [polypeptide binding]; other site 869727001529 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 869727001530 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869727001531 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869727001532 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Region: accA; TIGR00513 869727001533 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 869727001534 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 869727001535 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869727001536 dimer interface [polypeptide binding]; other site 869727001537 active site 869727001538 acyl carrier protein; Provisional; Region: acpP; PRK00982 869727001539 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 869727001540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869727001541 NAD(P) binding site [chemical binding]; other site 869727001542 active site 869727001543 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869727001544 Predicted membrane protein [Function unknown]; Region: COG3059 869727001545 diaminopimelate epimerase; Region: DapF; TIGR00652 869727001546 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 869727001547 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 869727001548 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869727001549 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869727001550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727001551 FeS/SAM binding site; other site 869727001552 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 869727001553 GTP-binding protein YchF; Reviewed; Region: PRK09601 869727001554 YchF GTPase; Region: YchF; cd01900 869727001555 G1 box; other site 869727001556 GTP/Mg2+ binding site [chemical binding]; other site 869727001557 Switch I region; other site 869727001558 G2 box; other site 869727001559 Switch II region; other site 869727001560 G3 box; other site 869727001561 G4 box; other site 869727001562 G5 box; other site 869727001563 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869727001564 multifunctional aminopeptidase A; Provisional; Region: PRK00913 869727001565 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 869727001566 interface (dimer of trimers) [polypeptide binding]; other site 869727001567 Substrate-binding/catalytic site; other site 869727001568 Zn-binding sites [ion binding]; other site 869727001569 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869727001570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869727001571 active site 869727001572 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869727001573 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 869727001574 Peptidase family M50; Region: Peptidase_M50; pfam02163 869727001575 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 869727001576 active site 869727001577 putative substrate binding region [chemical binding]; other site 869727001578 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869727001579 signal peptidase I; Provisional; Region: PRK10861 869727001580 Catalytic site [active] 869727001581 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869727001582 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 869727001583 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869727001584 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869727001585 homodimer interface [polypeptide binding]; other site 869727001586 NADP binding site [chemical binding]; other site 869727001587 substrate binding site [chemical binding]; other site 869727001588 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 869727001589 Sulfatase; Region: Sulfatase; pfam00884 869727001590 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 869727001591 BNR repeat-like domain; Region: BNR_2; pfam13088 869727001592 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 869727001593 active site 869727001594 substrate binding pocket [chemical binding]; other site 869727001595 dimer interface [polypeptide binding]; other site 869727001596 potential frameshift: common BLAST hit: gi|15611596|ref|NP_223247.1| siderophore-mediated IRON transport protein 869727001597 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 869727001598 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 869727001599 flagellar motor switch protein; Validated; Region: PRK08433 869727001600 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869727001601 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869727001602 minor groove reading motif; other site 869727001603 helix-hairpin-helix signature motif; other site 869727001604 substrate binding pocket [chemical binding]; other site 869727001605 active site 869727001606 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 869727001607 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 869727001608 Protein of unknown function; Region: DUF3971; pfam13116 869727001609 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 869727001610 YceG-like family; Region: YceG; pfam02618 869727001611 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869727001612 dimerization interface [polypeptide binding]; other site 869727001613 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 869727001614 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869727001615 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 869727001616 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 869727001617 dimer interface [polypeptide binding]; other site 869727001618 PYR/PP interface [polypeptide binding]; other site 869727001619 TPP binding site [chemical binding]; other site 869727001620 substrate binding site [chemical binding]; other site 869727001621 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 869727001622 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 869727001623 TPP-binding site [chemical binding]; other site 869727001624 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 869727001625 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 869727001626 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 869727001627 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 869727001628 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 869727001629 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 869727001630 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869727001631 Transglycosylase; Region: Transgly; pfam00912 869727001632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869727001633 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 869727001634 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 869727001635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869727001636 catalytic residue [active] 869727001637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869727001638 dimer interface [polypeptide binding]; other site 869727001639 putative CheW interface [polypeptide binding]; other site 869727001640 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 869727001641 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869727001642 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869727001643 Walker A/P-loop; other site 869727001644 ATP binding site [chemical binding]; other site 869727001645 Q-loop/lid; other site 869727001646 ABC transporter signature motif; other site 869727001647 Walker B; other site 869727001648 D-loop; other site 869727001649 H-loop/switch region; other site 869727001650 flagellin A; Reviewed; Region: PRK12584 869727001651 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869727001652 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869727001653 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869727001654 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869727001655 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 869727001656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869727001657 minor groove reading motif; other site 869727001658 helix-hairpin-helix signature motif; other site 869727001659 active site 869727001660 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 869727001661 substrate binding site [chemical binding]; other site 869727001662 active site 869727001663 Outer membrane efflux protein; Region: OEP; pfam02321 869727001664 Outer membrane efflux protein; Region: OEP; pfam02321 869727001665 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869727001666 HlyD family secretion protein; Region: HlyD_3; pfam13437 869727001667 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 869727001668 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001669 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 869727001670 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727001671 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727001672 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727001673 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727001674 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 869727001675 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727001676 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869727001677 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869727001678 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869727001679 nucleotide binding pocket [chemical binding]; other site 869727001680 K-X-D-G motif; other site 869727001681 catalytic site [active] 869727001682 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869727001683 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869727001684 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869727001685 Dimer interface [polypeptide binding]; other site 869727001686 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 869727001687 Response regulator receiver domain; Region: Response_reg; pfam00072 869727001688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727001689 active site 869727001690 phosphorylation site [posttranslational modification] 869727001691 intermolecular recognition site; other site 869727001692 dimerization interface [polypeptide binding]; other site 869727001693 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869727001694 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869727001695 dimer interface [polypeptide binding]; other site 869727001696 anticodon binding site; other site 869727001697 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869727001698 homodimer interface [polypeptide binding]; other site 869727001699 motif 1; other site 869727001700 active site 869727001701 motif 2; other site 869727001702 GAD domain; Region: GAD; pfam02938 869727001703 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869727001704 active site 869727001705 motif 3; other site 869727001706 adenylate kinase; Reviewed; Region: adk; PRK00279 869727001707 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869727001708 AMP-binding site [chemical binding]; other site 869727001709 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869727001710 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 869727001711 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 869727001712 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 869727001713 Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306 869727001714 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 869727001715 dimer interface [polypeptide binding]; other site 869727001716 substrate binding site [chemical binding]; other site 869727001717 metal binding sites [ion binding]; metal-binding site 869727001718 MutS2 family protein; Region: mutS2; TIGR01069 869727001719 ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534 869727001720 Walker A/P-loop; other site 869727001721 ATP binding site [chemical binding]; other site 869727001722 Q-loop/lid; other site 869727001723 ABC transporter signature motif; other site 869727001724 Walker B; other site 869727001725 D-loop; other site 869727001726 H-loop/switch region; other site 869727001727 Smr domain; Region: Smr; pfam01713 869727001728 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 869727001729 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869727001730 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869727001731 hypothetical protein; Provisional; Region: PRK05839 869727001732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869727001733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727001734 homodimer interface [polypeptide binding]; other site 869727001735 catalytic residue [active] 869727001736 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 869727001737 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869727001738 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869727001739 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 869727001740 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 869727001741 putative trimer interface [polypeptide binding]; other site 869727001742 putative CoA binding site [chemical binding]; other site 869727001743 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727001744 Sel1-like repeats; Region: SEL1; smart00671 869727001745 Sel1-like repeats; Region: SEL1; smart00671 869727001746 Sel1 repeat; Region: Sel1; cl02723 869727001747 Sel1-like repeats; Region: SEL1; smart00671 869727001748 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727001749 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727001750 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727001751 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 869727001752 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 869727001753 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 869727001754 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 869727001755 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 869727001756 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 869727001757 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 869727001758 nickel binding site [ion binding]; other site 869727001759 putative substrate-binding site; other site 869727001760 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001761 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 869727001762 Ligand Binding Site [chemical binding]; other site 869727001763 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 869727001764 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869727001765 active site 869727001766 NTP binding site [chemical binding]; other site 869727001767 metal binding triad [ion binding]; metal-binding site 869727001768 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869727001769 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 869727001770 hydrophobic ligand binding site; other site 869727001771 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 869727001772 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869727001773 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 869727001774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869727001775 active site 869727001776 HIGH motif; other site 869727001777 nucleotide binding site [chemical binding]; other site 869727001778 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869727001779 active site 869727001780 KMSKS motif; other site 869727001781 YGGT family; Region: YGGT; pfam02325 869727001782 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 869727001783 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869727001784 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869727001785 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869727001786 catalytic residue [active] 869727001787 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869727001788 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869727001789 active site 869727001790 tetramer interface; other site 869727001791 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869727001792 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869727001793 hinge; other site 869727001794 active site 869727001795 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 869727001796 Aspartase; Region: Aspartase; cd01357 869727001797 active sites [active] 869727001798 tetramer interface [polypeptide binding]; other site 869727001799 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 869727001800 ligand binding site [chemical binding]; other site 869727001801 active site 869727001802 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 869727001803 phosphoserine phosphatase SerB; Region: serB; TIGR00338 869727001804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869727001805 motif II; other site 869727001806 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 869727001807 Ferritin-like domain; Region: Ferritin; pfam00210 869727001808 ferroxidase diiron center [ion binding]; other site 869727001809 hypothetical protein; Provisional; Region: PRK08444 869727001810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727001811 FeS/SAM binding site; other site 869727001812 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 869727001813 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869727001814 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869727001815 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869727001816 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869727001817 Surface antigen; Region: Bac_surface_Ag; pfam01103 869727001818 hypothetical protein; Provisional; Region: PRK08445 869727001819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727001820 FeS/SAM binding site; other site 869727001821 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869727001822 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869727001823 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869727001824 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869727001825 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869727001826 GatB domain; Region: GatB_Yqey; smart00845 869727001827 SurA N-terminal domain; Region: SurA_N; pfam09312 869727001828 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 869727001829 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 869727001830 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 869727001831 RNA/DNA hybrid binding site [nucleotide binding]; other site 869727001832 active site 869727001833 ribonuclease III; Reviewed; Region: rnc; PRK00102 869727001834 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869727001835 dimerization interface [polypeptide binding]; other site 869727001836 active site 869727001837 metal binding site [ion binding]; metal-binding site 869727001838 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869727001839 dsRNA binding site [nucleotide binding]; other site 869727001840 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869727001841 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869727001842 Tetramer interface [polypeptide binding]; other site 869727001843 active site 869727001844 FMN-binding site [chemical binding]; other site 869727001845 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 869727001846 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 869727001847 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 869727001848 HemN C-terminal domain; Region: HemN_C; pfam06969 869727001849 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 869727001850 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869727001851 Cysteine-rich domain; Region: CCG; pfam02754 869727001852 Cysteine-rich domain; Region: CCG; pfam02754 869727001853 Predicted helicase [General function prediction only]; Region: COG4889 869727001854 Restriction endonuclease; Region: Mrr_cat; pfam04471 869727001855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727001856 ATP binding site [chemical binding]; other site 869727001857 putative Mg++ binding site [ion binding]; other site 869727001858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727001859 nucleotide binding region [chemical binding]; other site 869727001860 ATP-binding site [chemical binding]; other site 869727001861 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 869727001862 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001863 aspartate aminotransferase; Provisional; Region: PRK05764 869727001864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869727001865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727001866 homodimer interface [polypeptide binding]; other site 869727001867 catalytic residue [active] 869727001868 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 869727001869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869727001870 active site 869727001871 DNA binding site [nucleotide binding] 869727001872 Int/Topo IB signature motif; other site 869727001873 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869727001874 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 869727001875 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869727001876 DNA binding site [nucleotide binding] 869727001877 active site 869727001878 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869727001879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869727001880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869727001881 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869727001882 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 869727001883 ATP cone domain; Region: ATP-cone; pfam03477 869727001884 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869727001885 active site 869727001886 dimer interface [polypeptide binding]; other site 869727001887 catalytic residues [active] 869727001888 effector binding site; other site 869727001889 R2 peptide binding site; other site 869727001890 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 869727001891 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869727001892 Substrate binding site; other site 869727001893 Mg++ binding site; other site 869727001894 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869727001895 active site 869727001896 substrate binding site [chemical binding]; other site 869727001897 CoA binding site [chemical binding]; other site 869727001898 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 869727001899 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 869727001900 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869727001901 N-terminal plug; other site 869727001902 ligand-binding site [chemical binding]; other site 869727001903 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 869727001904 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 869727001905 G1 box; other site 869727001906 GTP/Mg2+ binding site [chemical binding]; other site 869727001907 Switch I region; other site 869727001908 G2 box; other site 869727001909 G3 box; other site 869727001910 Switch II region; other site 869727001911 G4 box; other site 869727001912 G5 box; other site 869727001913 Nucleoside recognition; Region: Gate; pfam07670 869727001914 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 869727001915 Nucleoside recognition; Region: Gate; pfam07670 869727001916 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 869727001917 active site 869727001918 catalytic site [active] 869727001919 substrate binding site [chemical binding]; other site 869727001920 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 869727001921 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869727001922 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727001923 CfrBI restriction endonuclease; Region: RE_CfrBI; pfam09516 869727001924 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 869727001925 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 869727001926 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 869727001927 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 869727001928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 869727001929 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 869727001930 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 869727001931 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 869727001932 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 869727001933 putative acyltransferase; Provisional; Region: PRK05790 869727001934 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869727001935 dimer interface [polypeptide binding]; other site 869727001936 active site 869727001937 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869727001938 DNA gyrase subunit A; Validated; Region: PRK05560 869727001939 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869727001940 CAP-like domain; other site 869727001941 active site 869727001942 primary dimer interface [polypeptide binding]; other site 869727001943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001944 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001945 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001946 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001947 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001948 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869727001949 Response regulator receiver domain; Region: Response_reg; pfam00072 869727001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727001951 active site 869727001952 phosphorylation site [posttranslational modification] 869727001953 intermolecular recognition site; other site 869727001954 dimerization interface [polypeptide binding]; other site 869727001955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001956 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869727001957 Walker A motif; other site 869727001958 ATP binding site [chemical binding]; other site 869727001959 Walker B motif; other site 869727001960 arginine finger; other site 869727001961 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869727001962 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869727001963 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869727001964 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869727001965 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001966 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869727001967 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 869727001968 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869727001969 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869727001970 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 869727001971 Fic family protein [Function unknown]; Region: COG3177 869727001972 Fic/DOC family; Region: Fic; pfam02661 869727001973 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 869727001974 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 869727001975 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 869727001976 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 869727001977 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 869727001978 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 869727001979 Walker A/P-loop; other site 869727001980 ATP binding site [chemical binding]; other site 869727001981 Q-loop/lid; other site 869727001982 ABC transporter signature motif; other site 869727001983 Walker B; other site 869727001984 D-loop; other site 869727001985 H-loop/switch region; other site 869727001986 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 869727001987 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 869727001988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727001989 Walker A motif; other site 869727001990 ATP binding site [chemical binding]; other site 869727001991 Walker B motif; other site 869727001992 arginine finger; other site 869727001993 L-lysine exporter; Region: 2a75; TIGR00948 869727001994 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 869727001995 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 869727001996 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727001997 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 869727001998 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869727001999 FMN binding site [chemical binding]; other site 869727002000 active site 869727002001 catalytic residues [active] 869727002002 substrate binding site [chemical binding]; other site 869727002003 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869727002004 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869727002005 Ligand Binding Site [chemical binding]; other site 869727002006 potential frameshift: common BLAST hit: gi|208434641|ref|YP_002266307.1| labile enterotoxin outputA 869727002007 potential frameshift: common BLAST hit: gi|254779290|ref|YP_003057395.1| LeoA protein 869727002008 potential frameshift: common BLAST hit: gi|254779290|ref|YP_003057395.1| LeoA protein 869727002009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727002010 Walker A/P-loop; other site 869727002011 ATP binding site [chemical binding]; other site 869727002012 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 869727002013 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869727002014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727002015 FeS/SAM binding site; other site 869727002016 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 869727002017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869727002018 active site 869727002019 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 869727002020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869727002021 catalytic residue [active] 869727002022 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 869727002023 tetramer interfaces [polypeptide binding]; other site 869727002024 binuclear metal-binding site [ion binding]; other site 869727002025 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869727002026 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869727002027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869727002028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869727002029 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869727002030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869727002031 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 869727002032 nucleotide binding site/active site [active] 869727002033 HIT family signature motif; other site 869727002034 catalytic residue [active] 869727002035 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 869727002036 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869727002037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869727002038 active site 869727002039 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 869727002040 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 869727002041 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869727002042 G1 box; other site 869727002043 GTP/Mg2+ binding site [chemical binding]; other site 869727002044 G2 box; other site 869727002045 Switch I region; other site 869727002046 G3 box; other site 869727002047 Switch II region; other site 869727002048 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869727002049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869727002050 RNA binding surface [nucleotide binding]; other site 869727002051 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869727002052 active site 869727002053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 869727002054 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 869727002055 Interdomain contacts; other site 869727002056 Cytokine receptor motif; other site 869727002057 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 869727002058 Interdomain contacts; other site 869727002059 Cytokine receptor motif; other site 869727002060 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 869727002061 Interdomain contacts; other site 869727002062 Cytokine receptor motif; other site 869727002063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002064 S-adenosylmethionine binding site [chemical binding]; other site 869727002065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869727002066 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869727002067 Walker A/P-loop; other site 869727002068 ATP binding site [chemical binding]; other site 869727002069 Q-loop/lid; other site 869727002070 ABC transporter signature motif; other site 869727002071 Walker B; other site 869727002072 D-loop; other site 869727002073 H-loop/switch region; other site 869727002074 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 869727002075 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869727002076 Peptidase family M23; Region: Peptidase_M23; pfam01551 869727002077 flagellar protein FlaG; Provisional; Region: PRK08452 869727002078 flagellar capping protein; Validated; Region: fliD; PRK08453 869727002079 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 869727002080 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 869727002081 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 869727002082 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 869727002083 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 869727002084 putative ATP binding site [chemical binding]; other site 869727002085 putative substrate interface [chemical binding]; other site 869727002086 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 869727002087 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 869727002088 putative active site; other site 869727002089 catalytic triad [active] 869727002090 putative dimer interface [polypeptide binding]; other site 869727002091 Predicted permease [General function prediction only]; Region: COG2056 869727002092 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 869727002093 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 869727002094 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869727002095 putative efflux protein, MATE family; Region: matE; TIGR00797 869727002096 phosphodiesterase; Provisional; Region: PRK12704 869727002097 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 869727002098 nucleic acid binding region [nucleotide binding]; other site 869727002099 G-X-X-G motif; other site 869727002100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869727002101 Zn2+ binding site [ion binding]; other site 869727002102 Mg2+ binding site [ion binding]; other site 869727002103 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 869727002104 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 869727002105 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869727002106 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 869727002107 Mu-like prophage protein [General function prediction only]; Region: COG3941 869727002108 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 869727002109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727002110 FeS/SAM binding site; other site 869727002111 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 869727002112 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 869727002113 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 869727002114 GTP binding site; other site 869727002115 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 869727002116 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 869727002117 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 869727002118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869727002119 active site 869727002120 metal binding site [ion binding]; metal-binding site 869727002121 Nitronate monooxygenase; Region: NMO; pfam03060 869727002122 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869727002123 FMN binding site [chemical binding]; other site 869727002124 substrate binding site [chemical binding]; other site 869727002125 putative catalytic residue [active] 869727002126 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869727002127 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869727002128 active site 869727002129 HIGH motif; other site 869727002130 dimer interface [polypeptide binding]; other site 869727002131 KMSKS motif; other site 869727002132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869727002133 RNA binding surface [nucleotide binding]; other site 869727002134 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 869727002135 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869727002136 Zn2+ binding site [ion binding]; other site 869727002137 Mg2+ binding site [ion binding]; other site 869727002138 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869727002139 synthetase active site [active] 869727002140 NTP binding site [chemical binding]; other site 869727002141 metal binding site [ion binding]; metal-binding site 869727002142 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869727002143 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 869727002144 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869727002145 putative nucleotide binding site [chemical binding]; other site 869727002146 uridine monophosphate binding site [chemical binding]; other site 869727002147 homohexameric interface [polypeptide binding]; other site 869727002148 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 869727002149 aconitate hydratase 2; Region: acnB; TIGR00117 869727002150 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 869727002151 substrate binding site [chemical binding]; other site 869727002152 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 869727002153 substrate binding site [chemical binding]; other site 869727002154 ligand binding site [chemical binding]; other site 869727002155 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 869727002156 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727002157 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 869727002158 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 869727002159 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869727002160 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869727002161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727002162 nucleotide binding region [chemical binding]; other site 869727002163 ATP-binding site [chemical binding]; other site 869727002164 SEC-C motif; Region: SEC-C; pfam02810 869727002165 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869727002166 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869727002167 FtsX-like permease family; Region: FtsX; pfam02687 869727002168 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727002169 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 869727002170 metal-binding site [ion binding] 869727002171 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 869727002172 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869727002173 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869727002174 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 869727002175 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869727002176 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 869727002177 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 869727002178 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869727002179 active site 869727002180 catalytic residues [active] 869727002181 metal binding site [ion binding]; metal-binding site 869727002182 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 869727002183 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869727002184 oligomer interface [polypeptide binding]; other site 869727002185 active site residues [active] 869727002186 trigger factor; Provisional; Region: tig; PRK01490 869727002187 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869727002188 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869727002189 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002190 potential frameshift: common BLAST hit: gi|15611800|ref|NP_223451.1| neuraminyllactose-binding hemagglutinin precursor 869727002191 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 869727002192 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 869727002193 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 869727002194 trimer interface [polypeptide binding]; other site 869727002195 dimer interface [polypeptide binding]; other site 869727002196 putative active site [active] 869727002197 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 869727002198 MPT binding site; other site 869727002199 trimer interface [polypeptide binding]; other site 869727002200 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 869727002201 MoaE homodimer interface [polypeptide binding]; other site 869727002202 MoaD interaction [polypeptide binding]; other site 869727002203 active site residues [active] 869727002204 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 869727002205 MoaE interaction surface [polypeptide binding]; other site 869727002206 MoeB interaction surface [polypeptide binding]; other site 869727002207 thiocarboxylated glycine; other site 869727002208 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869727002209 dimerization interface [polypeptide binding]; other site 869727002210 active site 869727002211 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 869727002212 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 869727002213 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: ribB; TIGR00506 869727002214 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 869727002215 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 869727002216 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 869727002217 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 869727002218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869727002219 N-terminal plug; other site 869727002220 ligand-binding site [chemical binding]; other site 869727002221 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 869727002222 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 869727002223 RNA methyltransferase, RsmD family; Region: TIGR00095 869727002224 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 869727002225 Uncharacterized conserved protein [Function unknown]; Region: COG1565 869727002226 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869727002227 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 869727002228 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 869727002229 ATP binding site [chemical binding]; other site 869727002230 substrate interface [chemical binding]; other site 869727002231 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 869727002232 flagellar motor protein MotA; Validated; Region: PRK08456 869727002233 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 869727002234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869727002235 ligand binding site [chemical binding]; other site 869727002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727002237 dimer interface [polypeptide binding]; other site 869727002238 conserved gate region; other site 869727002239 ABC-ATPase subunit interface; other site 869727002240 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869727002241 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869727002242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727002243 Walker A/P-loop; other site 869727002244 ATP binding site [chemical binding]; other site 869727002245 Q-loop/lid; other site 869727002246 ABC transporter signature motif; other site 869727002247 Walker B; other site 869727002248 D-loop; other site 869727002249 H-loop/switch region; other site 869727002250 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 869727002251 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869727002252 GIY-YIG motif/motif A; other site 869727002253 active site 869727002254 catalytic site [active] 869727002255 putative DNA binding site [nucleotide binding]; other site 869727002256 metal binding site [ion binding]; metal-binding site 869727002257 UvrB/uvrC motif; Region: UVR; pfam02151 869727002258 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869727002259 homoserine dehydrogenase; Provisional; Region: PRK06349 869727002260 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869727002261 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869727002262 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869727002263 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 869727002264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869727002265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869727002266 catalytic residues [active] 869727002267 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869727002268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869727002269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869727002270 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 869727002271 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 869727002272 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869727002273 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869727002274 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869727002275 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869727002276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869727002277 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869727002278 active site 869727002279 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 869727002280 indole acetimide hydrolase; Validated; Region: PRK07488 869727002281 dephospho-CoA kinase; Region: TIGR00152 869727002282 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869727002283 CoA-binding site [chemical binding]; other site 869727002284 ATP-binding [chemical binding]; other site 869727002285 spermidine synthase; Provisional; Region: speE; PRK00536 869727002286 spermidine synthase; Provisional; Region: PRK00811 869727002287 GTP-binding protein Der; Reviewed; Region: PRK00093 869727002288 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869727002289 G1 box; other site 869727002290 GTP/Mg2+ binding site [chemical binding]; other site 869727002291 Switch I region; other site 869727002292 G2 box; other site 869727002293 Switch II region; other site 869727002294 G3 box; other site 869727002295 G4 box; other site 869727002296 G5 box; other site 869727002297 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869727002298 G1 box; other site 869727002299 GTP/Mg2+ binding site [chemical binding]; other site 869727002300 Switch I region; other site 869727002301 G2 box; other site 869727002302 G3 box; other site 869727002303 Switch II region; other site 869727002304 G4 box; other site 869727002305 G5 box; other site 869727002306 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869727002307 IHF dimer interface [polypeptide binding]; other site 869727002308 IHF - DNA interface [nucleotide binding]; other site 869727002309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 869727002310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 869727002311 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 869727002312 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 869727002313 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869727002314 NAD(P) binding site [chemical binding]; other site 869727002315 homodimer interface [polypeptide binding]; other site 869727002316 substrate binding site [chemical binding]; other site 869727002317 active site 869727002318 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 869727002319 Flavoprotein; Region: Flavoprotein; pfam02441 869727002320 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 869727002321 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869727002322 thiamine phosphate binding site [chemical binding]; other site 869727002323 active site 869727002324 pyrophosphate binding site [ion binding]; other site 869727002325 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869727002326 dimer interface [polypeptide binding]; other site 869727002327 substrate binding site [chemical binding]; other site 869727002328 ATP binding site [chemical binding]; other site 869727002329 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869727002330 substrate binding site [chemical binding]; other site 869727002331 multimerization interface [polypeptide binding]; other site 869727002332 ATP binding site [chemical binding]; other site 869727002333 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 869727002334 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869727002335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727002336 ATP binding site [chemical binding]; other site 869727002337 putative Mg++ binding site [ion binding]; other site 869727002338 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 869727002339 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869727002340 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869727002341 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 869727002342 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869727002343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002344 S-adenosylmethionine binding site [chemical binding]; other site 869727002345 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869727002346 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869727002347 active site 869727002348 Protein of unknown function (DUF511); Region: DUF511; cl01114 869727002349 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869727002350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727002351 Walker A/P-loop; other site 869727002352 ATP binding site [chemical binding]; other site 869727002353 Q-loop/lid; other site 869727002354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869727002355 ABC transporter; Region: ABC_tran_2; pfam12848 869727002356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869727002357 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869727002358 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869727002359 active site 869727002360 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869727002361 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 869727002362 dimer interface [polypeptide binding]; other site 869727002363 active site 869727002364 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 869727002365 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 869727002366 putative ribose interaction site [chemical binding]; other site 869727002367 putative ADP binding site [chemical binding]; other site 869727002368 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 869727002369 active site 869727002370 nucleotide binding site [chemical binding]; other site 869727002371 HIGH motif; other site 869727002372 KMSKS motif; other site 869727002373 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 869727002374 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 869727002375 NADP binding site [chemical binding]; other site 869727002376 homopentamer interface [polypeptide binding]; other site 869727002377 substrate binding site [chemical binding]; other site 869727002378 active site 869727002379 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 869727002380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869727002381 active site 869727002382 motif I; other site 869727002383 motif II; other site 869727002384 Uncharacterized conserved protein [Function unknown]; Region: COG2836 869727002385 pantothenate kinase; Reviewed; Region: PRK13333 869727002386 PQQ-like domain; Region: PQQ_2; pfam13360 869727002387 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869727002388 trimer interface [polypeptide binding]; other site 869727002389 active site 869727002390 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869727002391 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869727002392 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869727002393 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 869727002394 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 869727002395 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 869727002396 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 869727002397 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 869727002398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869727002399 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 869727002400 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 869727002401 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869727002402 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 869727002403 alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686 869727002404 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869727002405 PhnA protein; Region: PhnA; pfam03831 869727002406 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 869727002407 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 869727002408 tetramer interface [polypeptide binding]; other site 869727002409 heme binding pocket [chemical binding]; other site 869727002410 NADPH binding site [chemical binding]; other site 869727002411 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 869727002412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869727002413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869727002414 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 869727002415 active site 869727002416 putative DNA-binding cleft [nucleotide binding]; other site 869727002417 dimer interface [polypeptide binding]; other site 869727002418 Uncharacterized conserved protein [Function unknown]; Region: COG1432 869727002419 LabA_like proteins; Region: LabA_like; cd06167 869727002420 putative metal binding site [ion binding]; other site 869727002421 Glutaminase; Region: Glutaminase; cl00907 869727002422 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 869727002423 RuvA N terminal domain; Region: RuvA_N; pfam01330 869727002424 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 869727002425 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 869727002426 MviN-like protein; Region: MVIN; pfam03023 869727002427 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869727002428 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869727002429 active site 869727002430 HIGH motif; other site 869727002431 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869727002432 KMSKS motif; other site 869727002433 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869727002434 tRNA binding surface [nucleotide binding]; other site 869727002435 anticodon binding site; other site 869727002436 potential frameshift: common BLAST hit: gi|15611886|ref|NP_223537.1| vacuolating cytotoxin 869727002437 Vacuolating cyotoxin; Region: VacA; pfam02691 869727002438 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869727002439 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727002440 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869727002441 Ligand binding site; other site 869727002442 metal-binding site 869727002443 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869727002444 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869727002445 Walker A/P-loop; other site 869727002446 ATP binding site [chemical binding]; other site 869727002447 Q-loop/lid; other site 869727002448 ABC transporter signature motif; other site 869727002449 Walker B; other site 869727002450 D-loop; other site 869727002451 H-loop/switch region; other site 869727002452 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 869727002453 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869727002454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869727002455 ABC-ATPase subunit interface; other site 869727002456 dimer interface [polypeptide binding]; other site 869727002457 putative PBP binding regions; other site 869727002458 short chain dehydrogenase; Validated; Region: PRK06182 869727002459 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 869727002460 NADP binding site [chemical binding]; other site 869727002461 active site 869727002462 steroid binding site; other site 869727002463 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 869727002464 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 869727002465 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 869727002466 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 869727002467 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 869727002468 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 869727002469 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869727002470 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 869727002471 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869727002472 propionate/acetate kinase; Provisional; Region: PRK12379 869727002473 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 869727002474 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869727002475 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 869727002476 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 869727002477 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 869727002478 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869727002479 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 869727002480 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869727002481 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869727002482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002483 S-adenosylmethionine binding site [chemical binding]; other site 869727002484 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869727002485 Part of AAA domain; Region: AAA_19; pfam13245 869727002486 Family description; Region: UvrD_C_2; pfam13538 869727002487 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002488 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002489 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727002490 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 869727002491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869727002492 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869727002493 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 869727002494 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869727002495 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869727002496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869727002497 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869727002498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869727002499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869727002500 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869727002501 IMP binding site; other site 869727002502 dimer interface [polypeptide binding]; other site 869727002503 interdomain contacts; other site 869727002504 partial ornithine binding site; other site 869727002505 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869727002506 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869727002507 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 869727002508 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 869727002509 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869727002510 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727002511 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727002512 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 869727002513 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 869727002514 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869727002515 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002516 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 869727002517 active site 1 [active] 869727002518 dimer interface [polypeptide binding]; other site 869727002519 hexamer interface [polypeptide binding]; other site 869727002520 active site 2 [active] 869727002521 recombination protein RecR; Region: recR; TIGR00615 869727002522 RecR protein; Region: RecR; pfam02132 869727002523 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869727002524 putative active site [active] 869727002525 putative metal-binding site [ion binding]; other site 869727002526 tetramer interface [polypeptide binding]; other site 869727002527 tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094 869727002528 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 869727002529 Permutation of conserved domain; other site 869727002530 active site 869727002531 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 869727002532 heat shock protein HtpX; Provisional; Region: PRK02870 869727002533 GTP cyclohydrolase I; Region: folE; TIGR00063 869727002534 GTP cyclohydrolase I; Provisional; Region: PLN03044 869727002535 active site 869727002536 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869727002537 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869727002538 substrate binding pocket [chemical binding]; other site 869727002539 chain length determination region; other site 869727002540 substrate-Mg2+ binding site; other site 869727002541 catalytic residues [active] 869727002542 aspartate-rich region 1; other site 869727002543 active site lid residues [active] 869727002544 aspartate-rich region 2; other site 869727002545 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 869727002546 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 869727002547 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 869727002548 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 869727002549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869727002550 Coenzyme A binding pocket [chemical binding]; other site 869727002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727002552 metabolite-proton symporter; Region: 2A0106; TIGR00883 869727002553 putative substrate translocation pore; other site 869727002554 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727002555 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727002556 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727002557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727002558 dimer interface [polypeptide binding]; other site 869727002559 conserved gate region; other site 869727002560 putative PBP binding loops; other site 869727002561 ABC-ATPase subunit interface; other site 869727002562 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869727002563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869727002564 substrate binding pocket [chemical binding]; other site 869727002565 membrane-bound complex binding site; other site 869727002566 hinge residues; other site 869727002567 alanine racemase; Region: alr; TIGR00492 869727002568 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869727002569 active site 869727002570 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869727002571 dimer interface [polypeptide binding]; other site 869727002572 substrate binding site [chemical binding]; other site 869727002573 catalytic residues [active] 869727002574 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869727002575 amino acid carrier protein; Region: agcS; TIGR00835 869727002576 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 869727002577 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869727002578 homotrimer interaction site [polypeptide binding]; other site 869727002579 putative active site [active] 869727002580 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 869727002581 TIGR01210 family protein; Region: TIGR01210 869727002582 Uncharacterized conserved protein [Function unknown]; Region: COG1576 869727002583 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 869727002584 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869727002585 putative recombination protein RecO; Provisional; Region: PRK13908 869727002586 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869727002587 potential frameshift: common BLAST hit: gi|15611955|ref|NP_223606.1| aldehyde dehydrogenase 869727002588 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 869727002589 dimer interface [polypeptide binding]; other site 869727002590 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 869727002591 FMN binding site [chemical binding]; other site 869727002592 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 869727002593 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869727002594 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869727002595 active site 869727002596 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 869727002597 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 869727002598 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869727002599 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 869727002600 Putative zinc ribbon domain; Region: DUF164; pfam02591 869727002601 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 869727002602 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869727002603 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869727002604 dimer interface [polypeptide binding]; other site 869727002605 motif 1; other site 869727002606 active site 869727002607 motif 2; other site 869727002608 motif 3; other site 869727002609 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869727002610 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869727002611 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869727002612 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 869727002613 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 869727002614 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 869727002615 Outer membrane efflux protein; Region: OEP; pfam02321 869727002616 Outer membrane efflux protein; Region: OEP; pfam02321 869727002617 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 869727002618 phosphoglyceromutase; Provisional; Region: PRK05434 869727002619 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 869727002620 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 869727002621 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 869727002622 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869727002623 inhibitor-cofactor binding pocket; inhibition site 869727002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727002625 catalytic residue [active] 869727002626 SurA N-terminal domain; Region: SurA_N_3; cl07813 869727002627 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 869727002628 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 869727002629 cell division protein FtsA; Region: ftsA; TIGR01174 869727002630 Cell division protein FtsA; Region: FtsA; smart00842 869727002631 Cell division protein FtsA; Region: FtsA; pfam14450 869727002632 cell division protein FtsZ; Validated; Region: PRK09330 869727002633 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869727002634 nucleotide binding site [chemical binding]; other site 869727002635 SulA interaction site; other site 869727002636 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869727002637 potential frameshift: common BLAST hit: gi|188527700|ref|YP_001910387.1| topoisomerase I 869727002638 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 869727002639 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 869727002640 active site 869727002641 interdomain interaction site; other site 869727002642 putative metal-binding site [ion binding]; other site 869727002643 nucleotide binding site [chemical binding]; other site 869727002644 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 869727002645 domain I; other site 869727002646 DNA binding groove [nucleotide binding] 869727002647 phosphate binding site [ion binding]; other site 869727002648 domain II; other site 869727002649 domain III; other site 869727002650 nucleotide binding site [chemical binding]; other site 869727002651 catalytic site [active] 869727002652 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 869727002653 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 869727002654 domain IV; other site 869727002655 potential frameshift: common BLAST hit: gi|15612561|ref|NP_223640.1| conjugal plasmid transfer system protein 869727002656 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 869727002657 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 869727002658 potential frameshift: common BLAST hit: gi|308183674|ref|YP_003927801.1| VirB11 type IV secretion ATPase 869727002659 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 869727002660 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727002661 Walker A motif; other site 869727002662 ATP binding site [chemical binding]; other site 869727002663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727002664 Walker B motif; other site 869727002665 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 869727002666 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727002667 Walker A motif; other site 869727002668 ATP binding site [chemical binding]; other site 869727002669 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869727002670 Walker B motif; other site 869727002671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 869727002672 potential frameshift: common BLAST hit: gi|210134634|ref|YP_002301073.1| integrase/recombinase XercD family 869727002673 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869727002674 active site 869727002675 catalytic residues [active] 869727002676 DNA binding site [nucleotide binding] 869727002677 Int/Topo IB signature motif; other site 869727002678 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 869727002679 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727002680 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727002681 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727002682 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727002683 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727002684 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727002685 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 869727002686 YcfA-like protein; Region: YcfA; cl00752 869727002687 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 869727002688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 869727002689 active site 869727002690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869727002691 catalytic residues [active] 869727002692 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 869727002693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869727002694 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869727002695 putative ADP-binding pocket [chemical binding]; other site 869727002696 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 869727002697 Methyltransferase domain; Region: Methyltransf_23; pfam13489 869727002698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002699 S-adenosylmethionine binding site [chemical binding]; other site 869727002700 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 869727002701 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869727002702 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869727002703 active site 869727002704 HIGH motif; other site 869727002705 KMSKS motif; other site 869727002706 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869727002707 anticodon binding site; other site 869727002708 tRNA binding surface [nucleotide binding]; other site 869727002709 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869727002710 dimer interface [polypeptide binding]; other site 869727002711 putative tRNA-binding site [nucleotide binding]; other site 869727002712 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 869727002713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002714 S-adenosylmethionine binding site [chemical binding]; other site 869727002715 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869727002716 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869727002717 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 869727002718 GMP synthase; Reviewed; Region: guaA; PRK00074 869727002719 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869727002720 AMP/PPi binding site [chemical binding]; other site 869727002721 candidate oxyanion hole; other site 869727002722 catalytic triad [active] 869727002723 potential glutamine specificity residues [chemical binding]; other site 869727002724 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869727002725 ATP Binding subdomain [chemical binding]; other site 869727002726 Ligand Binding sites [chemical binding]; other site 869727002727 Dimerization subdomain; other site 869727002728 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 869727002729 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 869727002730 molybdopterin cofactor binding site [chemical binding]; other site 869727002731 substrate binding site [chemical binding]; other site 869727002732 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 869727002733 molybdopterin cofactor binding site; other site 869727002734 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 869727002735 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869727002736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869727002737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869727002738 catalytic residue [active] 869727002739 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 869727002740 nucleotide binding site/active site [active] 869727002741 HIT family signature motif; other site 869727002742 catalytic residue [active] 869727002743 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869727002744 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869727002745 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869727002746 dimer interface [polypeptide binding]; other site 869727002747 motif 1; other site 869727002748 active site 869727002749 motif 2; other site 869727002750 motif 3; other site 869727002751 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869727002752 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869727002753 putative tRNA-binding site [nucleotide binding]; other site 869727002754 tRNA synthetase B5 domain; Region: B5; pfam03484 869727002755 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869727002756 dimer interface [polypeptide binding]; other site 869727002757 motif 1; other site 869727002758 motif 3; other site 869727002759 motif 2; other site 869727002760 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 869727002761 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869727002762 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 869727002763 hinge; other site 869727002764 active site 869727002765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 869727002766 LytB protein; Region: LYTB; pfam02401 869727002767 ribosomal protein S1; Region: rpsA; TIGR00717 869727002768 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869727002769 RNA binding site [nucleotide binding]; other site 869727002770 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869727002771 RNA binding site [nucleotide binding]; other site 869727002772 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869727002773 RNA binding site [nucleotide binding]; other site 869727002774 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869727002775 RNA binding site [nucleotide binding]; other site 869727002776 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 869727002777 RNA binding site [nucleotide binding]; other site 869727002778 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 869727002779 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 869727002780 ligand binding site [chemical binding]; other site 869727002781 NAD binding site [chemical binding]; other site 869727002782 dimerization interface [polypeptide binding]; other site 869727002783 catalytic site [active] 869727002784 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 869727002785 putative L-serine binding site [chemical binding]; other site 869727002786 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 869727002787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869727002788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869727002789 catalytic residue [active] 869727002790 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 869727002791 putative active site [active] 869727002792 putative metal binding site [ion binding]; other site 869727002793 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 869727002794 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 869727002795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727002796 active site 869727002797 phosphorylation site [posttranslational modification] 869727002798 intermolecular recognition site; other site 869727002799 dimerization interface [polypeptide binding]; other site 869727002800 potential frameshift: common BLAST hit: gi|308183165|ref|YP_003927292.1| auto phosphorylating histidine kinase 869727002801 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869727002802 putative binding surface; other site 869727002803 active site 869727002804 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 869727002805 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 869727002806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727002807 ATP binding site [chemical binding]; other site 869727002808 Mg2+ binding site [ion binding]; other site 869727002809 G-X-G motif; other site 869727002810 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 869727002811 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 869727002812 Response regulator receiver domain; Region: Response_reg; pfam00072 869727002813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727002814 active site 869727002815 phosphorylation site [posttranslational modification] 869727002816 intermolecular recognition site; other site 869727002817 dimerization interface [polypeptide binding]; other site 869727002818 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 869727002819 putative CheA interaction surface; other site 869727002820 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869727002821 dimer interface [polypeptide binding]; other site 869727002822 catalytic triad [active] 869727002823 peroxidatic and resolving cysteines [active] 869727002824 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869727002825 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869727002826 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869727002827 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 869727002828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002829 S-adenosylmethionine binding site [chemical binding]; other site 869727002830 primosome assembly protein PriA; Validated; Region: PRK05580 869727002831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727002832 ATP binding site [chemical binding]; other site 869727002833 putative Mg++ binding site [ion binding]; other site 869727002834 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869727002835 Sporulation related domain; Region: SPOR; pfam05036 869727002836 potential frameshift: common BLAST hit: gi|298735927|ref|YP_003728452.1| putative zinc-metallo protease 869727002837 Peptidase family M48; Region: Peptidase_M48; pfam01435 869727002838 Peptidase family M48; Region: Peptidase_M48; cl12018 869727002839 HemK family putative methylases; Region: hemK_fam; TIGR00536 869727002840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869727002841 glutamate dehydrogenase; Provisional; Region: PRK09414 869727002842 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869727002843 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869727002844 NAD(P) binding site [chemical binding]; other site 869727002845 potential frameshift: common BLAST hit: gi|15612067|ref|NP_223719.1| alpha-(1,3)-fucosyltransferase 869727002846 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 869727002847 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 869727002848 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 869727002849 catalytic residues [active] 869727002850 ferrochelatase; Region: hemH; TIGR00109 869727002851 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869727002852 C-terminal domain interface [polypeptide binding]; other site 869727002853 active site 869727002854 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869727002855 active site 869727002856 N-terminal domain interface [polypeptide binding]; other site 869727002857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869727002858 RNA methyltransferase, RsmE family; Region: TIGR00046 869727002859 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002860 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869727002861 trimer interface [polypeptide binding]; other site 869727002862 active site 869727002863 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 869727002864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869727002865 carboxyltransferase (CT) interaction site; other site 869727002866 biotinylation site [posttranslational modification]; other site 869727002867 biotin carboxylase; Validated; Region: PRK08462 869727002868 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869727002869 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869727002870 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869727002871 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869727002872 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869727002873 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869727002874 inhibitor-cofactor binding pocket; inhibition site 869727002875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727002876 catalytic residue [active] 869727002877 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869727002878 dimer interface [polypeptide binding]; other site 869727002879 putative radical transfer pathway; other site 869727002880 diiron center [ion binding]; other site 869727002881 tyrosyl radical; other site 869727002882 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 869727002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727002884 S-adenosylmethionine binding site [chemical binding]; other site 869727002885 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869727002886 Predicted permeases [General function prediction only]; Region: COG0795 869727002887 tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071 869727002888 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869727002889 dimerization interface 3.5A [polypeptide binding]; other site 869727002890 active site 869727002891 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 869727002892 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869727002893 NAD binding site [chemical binding]; other site 869727002894 homodimer interface [polypeptide binding]; other site 869727002895 active site 869727002896 substrate binding site [chemical binding]; other site 869727002897 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 869727002898 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869727002899 putative NAD(P) binding site [chemical binding]; other site 869727002900 homodimer interface [polypeptide binding]; other site 869727002901 homotetramer interface [polypeptide binding]; other site 869727002902 active site 869727002903 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727002904 Sel1-like repeats; Region: SEL1; smart00671 869727002905 Sel1-like repeats; Region: SEL1; smart00671 869727002906 Sel1 repeat; Region: Sel1; cl02723 869727002907 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727002908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727002909 binding surface 869727002910 TPR motif; other site 869727002911 Entner-Doudoroff aldolase; Region: eda; TIGR01182 869727002912 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869727002913 active site 869727002914 intersubunit interface [polypeptide binding]; other site 869727002915 catalytic residue [active] 869727002916 phosphogluconate dehydratase; Validated; Region: PRK09054 869727002917 6-phosphogluconate dehydratase; Region: edd; TIGR01196 869727002918 Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364 869727002919 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869727002920 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869727002921 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869727002922 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 869727002923 putative active site [active] 869727002924 glucokinase, proteobacterial type; Region: glk; TIGR00749 869727002925 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869727002926 nucleotide binding site [chemical binding]; other site 869727002927 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 869727002928 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 869727002929 putative NAD(P) binding site [chemical binding]; other site 869727002930 putative substrate binding site [chemical binding]; other site 869727002931 catalytic Zn binding site [ion binding]; other site 869727002932 structural Zn binding site [ion binding]; other site 869727002933 dimer interface [polypeptide binding]; other site 869727002934 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727002935 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727002936 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869727002937 active site 869727002938 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002939 pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844 869727002940 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 869727002941 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 869727002942 4Fe-4S binding domain; Region: Fer4; pfam00037 869727002943 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 869727002944 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 869727002945 dimer interface [polypeptide binding]; other site 869727002946 PYR/PP interface [polypeptide binding]; other site 869727002947 TPP binding site [chemical binding]; other site 869727002948 substrate binding site [chemical binding]; other site 869727002949 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869727002950 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 869727002951 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 869727002952 TPP-binding site [chemical binding]; other site 869727002953 putative dimer interface [polypeptide binding]; other site 869727002954 adenylosuccinate lyase; Provisional; Region: PRK08470 869727002955 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869727002956 tetramer interface [polypeptide binding]; other site 869727002957 active site 869727002958 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 869727002959 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727002960 excinuclease ABC subunit B; Provisional; Region: PRK05298 869727002961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727002962 ATP binding site [chemical binding]; other site 869727002963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869727002964 putative Mg++ binding site [ion binding]; other site 869727002965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727002966 nucleotide binding region [chemical binding]; other site 869727002967 ATP-binding site [chemical binding]; other site 869727002968 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869727002969 UvrB/uvrC motif; Region: UVR; pfam02151 869727002970 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 869727002971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727002972 binding surface 869727002973 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869727002974 TPR motif; other site 869727002975 Sel1-like repeats; Region: SEL1; smart00671 869727002976 Sel1-like repeats; Region: SEL1; smart00671 869727002977 Sel1-like repeats; Region: SEL1; smart00671 869727002978 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 869727002979 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 869727002980 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 869727002981 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869727002982 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869727002983 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 869727002984 cofactor binding site; other site 869727002985 DNA binding site [nucleotide binding] 869727002986 substrate interaction site [chemical binding]; other site 869727002987 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 869727002988 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 869727002989 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869727002990 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 869727002991 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869727002992 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869727002993 ligand binding site [chemical binding]; other site 869727002994 translocation protein TolB; Provisional; Region: tolB; PRK04043 869727002995 TolB amino-terminal domain; Region: TolB_N; pfam04052 869727002996 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 869727002997 TonB C terminal; Region: TonB_2; pfam13103 869727002998 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869727002999 TolR protein; Region: tolR; TIGR02801 869727003000 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 869727003001 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 869727003002 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869727003003 gamma subunit interface [polypeptide binding]; other site 869727003004 epsilon subunit interface [polypeptide binding]; other site 869727003005 LBP interface [polypeptide binding]; other site 869727003006 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869727003007 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869727003008 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869727003009 alpha subunit interaction interface [polypeptide binding]; other site 869727003010 Walker A motif; other site 869727003011 ATP binding site [chemical binding]; other site 869727003012 Walker B motif; other site 869727003013 inhibitor binding site; inhibition site 869727003014 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869727003015 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869727003016 core domain interface [polypeptide binding]; other site 869727003017 delta subunit interface [polypeptide binding]; other site 869727003018 epsilon subunit interface [polypeptide binding]; other site 869727003019 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869727003020 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869727003021 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869727003022 beta subunit interaction interface [polypeptide binding]; other site 869727003023 Walker A motif; other site 869727003024 ATP binding site [chemical binding]; other site 869727003025 Walker B motif; other site 869727003026 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869727003027 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13431 869727003028 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 869727003029 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 869727003030 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 869727003031 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869727003032 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869727003033 ParB-like nuclease domain; Region: ParB; smart00470 869727003034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 869727003035 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869727003036 P-loop; other site 869727003037 Magnesium ion binding site [ion binding]; other site 869727003038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869727003039 Magnesium ion binding site [ion binding]; other site 869727003040 biotin--protein ligase; Provisional; Region: PRK08477 869727003041 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869727003042 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869727003043 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869727003044 putative active site [active] 869727003045 substrate binding site [chemical binding]; other site 869727003046 putative cosubstrate binding site; other site 869727003047 catalytic site [active] 869727003048 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869727003049 substrate binding site [chemical binding]; other site 869727003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 869727003051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 869727003052 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 869727003053 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869727003054 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 869727003055 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 869727003056 RimM N-terminal domain; Region: RimM; pfam01782 869727003057 PRC-barrel domain; Region: PRC; pfam05239 869727003058 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869727003059 KH domain; Region: KH_4; pfam13083 869727003060 G-X-X-G motif; other site 869727003061 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 869727003062 signal recognition particle protein; Provisional; Region: PRK10867 869727003063 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869727003064 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869727003065 P loop; other site 869727003066 GTP binding site [chemical binding]; other site 869727003067 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869727003068 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869727003069 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869727003070 active site 869727003071 HIGH motif; other site 869727003072 nucleotide binding site [chemical binding]; other site 869727003073 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869727003074 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869727003075 active site 869727003076 KMSKS motif; other site 869727003077 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869727003078 anticodon binding site; other site 869727003079 flagellar assembly protein FliW; Provisional; Region: PRK13283 869727003080 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 869727003081 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869727003082 active site 869727003083 homodimer interface [polypeptide binding]; other site 869727003084 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003085 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003086 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 869727003087 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 869727003088 potential frameshift: common BLAST hit: gi|15612151|ref|NP_223803.1| cAMP-induced cell filamentation protein 869727003089 Fic/DOC family; Region: Fic; cl00960 869727003090 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869727003091 metal-binding heat shock protein; Provisional; Region: PRK00016 869727003092 flavodoxin FldA; Validated; Region: PRK09267 869727003093 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869727003094 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869727003095 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 869727003096 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869727003097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869727003098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869727003099 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 869727003100 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869727003101 active site 869727003102 dimer interface [polypeptide binding]; other site 869727003103 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869727003104 dimer interface [polypeptide binding]; other site 869727003105 active site 869727003106 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 869727003107 carbon starvation protein A; Provisional; Region: PRK15015 869727003108 Carbon starvation protein CstA; Region: CstA; pfam02554 869727003109 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 869727003110 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869727003111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727003112 dimer interface [polypeptide binding]; other site 869727003113 conserved gate region; other site 869727003114 putative PBP binding loops; other site 869727003115 ABC-ATPase subunit interface; other site 869727003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727003117 dimer interface [polypeptide binding]; other site 869727003118 conserved gate region; other site 869727003119 putative PBP binding loops; other site 869727003120 ABC-ATPase subunit interface; other site 869727003121 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869727003122 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869727003123 Walker A/P-loop; other site 869727003124 ATP binding site [chemical binding]; other site 869727003125 Q-loop/lid; other site 869727003126 ABC transporter signature motif; other site 869727003127 Walker B; other site 869727003128 D-loop; other site 869727003129 H-loop/switch region; other site 869727003130 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869727003131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869727003132 substrate binding pocket [chemical binding]; other site 869727003133 membrane-bound complex binding site; other site 869727003134 hinge residues; other site 869727003135 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 869727003136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727003137 putative substrate translocation pore; other site 869727003138 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869727003139 potential frameshift: common BLAST hit: gi|298736422|ref|YP_003728948.1| mesentericin Y105 secretion protein MesE 869727003140 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003141 purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107 869727003142 phosphopentomutase; Provisional; Region: PRK05362 869727003143 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869727003144 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869727003145 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 869727003146 Nucleoside recognition; Region: Gate; pfam07670 869727003147 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869727003148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727003149 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869727003150 putative substrate translocation pore; other site 869727003151 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 869727003152 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 869727003153 Ligand Binding Site [chemical binding]; other site 869727003154 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 869727003155 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 869727003156 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869727003157 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 869727003158 putative arabinose transporter; Provisional; Region: PRK03545 869727003159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869727003160 putative substrate translocation pore; other site 869727003161 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 869727003162 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 869727003163 active site 869727003164 zinc binding site [ion binding]; other site 869727003165 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 869727003166 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 869727003167 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869727003168 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 869727003169 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869727003170 dimer interface [polypeptide binding]; other site 869727003171 motif 1; other site 869727003172 active site 869727003173 motif 2; other site 869727003174 motif 3; other site 869727003175 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869727003176 anticodon binding site; other site 869727003177 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869727003178 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869727003179 putative active site [active] 869727003180 elongation factor G; Reviewed; Region: PRK00007 869727003181 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869727003182 G1 box; other site 869727003183 putative GEF interaction site [polypeptide binding]; other site 869727003184 GTP/Mg2+ binding site [chemical binding]; other site 869727003185 Switch I region; other site 869727003186 G2 box; other site 869727003187 G3 box; other site 869727003188 Switch II region; other site 869727003189 G4 box; other site 869727003190 G5 box; other site 869727003191 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869727003192 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869727003193 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869727003194 30S ribosomal protein S7; Validated; Region: PRK05302 869727003195 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869727003196 S17 interaction site [polypeptide binding]; other site 869727003197 S8 interaction site; other site 869727003198 16S rRNA interaction site [nucleotide binding]; other site 869727003199 streptomycin interaction site [chemical binding]; other site 869727003200 23S rRNA interaction site [nucleotide binding]; other site 869727003201 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869727003202 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 869727003203 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869727003204 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869727003205 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869727003206 RPB11 interaction site [polypeptide binding]; other site 869727003207 RPB12 interaction site [polypeptide binding]; other site 869727003208 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869727003209 RPB3 interaction site [polypeptide binding]; other site 869727003210 RPB1 interaction site [polypeptide binding]; other site 869727003211 RPB11 interaction site [polypeptide binding]; other site 869727003212 RPB10 interaction site [polypeptide binding]; other site 869727003213 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869727003214 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869727003215 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869727003216 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869727003217 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869727003218 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 869727003219 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869727003220 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869727003221 DNA binding site [nucleotide binding] 869727003222 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869727003223 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869727003224 core dimer interface [polypeptide binding]; other site 869727003225 peripheral dimer interface [polypeptide binding]; other site 869727003226 L10 interface [polypeptide binding]; other site 869727003227 L11 interface [polypeptide binding]; other site 869727003228 putative EF-Tu interaction site [polypeptide binding]; other site 869727003229 putative EF-G interaction site [polypeptide binding]; other site 869727003230 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869727003231 23S rRNA interface [nucleotide binding]; other site 869727003232 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869727003233 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869727003234 mRNA/rRNA interface [nucleotide binding]; other site 869727003235 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869727003236 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869727003237 23S rRNA interface [nucleotide binding]; other site 869727003238 L7/L12 interface [polypeptide binding]; other site 869727003239 putative thiostrepton binding site; other site 869727003240 L25 interface [polypeptide binding]; other site 869727003241 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869727003242 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869727003243 putative homodimer interface [polypeptide binding]; other site 869727003244 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869727003245 heterodimer interface [polypeptide binding]; other site 869727003246 homodimer interface [polypeptide binding]; other site 869727003247 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869727003248 elongation factor Tu; Reviewed; Region: PRK00049 869727003249 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869727003250 G1 box; other site 869727003251 GEF interaction site [polypeptide binding]; other site 869727003252 GTP/Mg2+ binding site [chemical binding]; other site 869727003253 Switch I region; other site 869727003254 G2 box; other site 869727003255 G3 box; other site 869727003256 Switch II region; other site 869727003257 G4 box; other site 869727003258 G5 box; other site 869727003259 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869727003260 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869727003261 Antibiotic Binding Site [chemical binding]; other site 869727003262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869727003263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727003264 Walker A/P-loop; other site 869727003265 ATP binding site [chemical binding]; other site 869727003266 Q-loop/lid; other site 869727003267 ABC transporter signature motif; other site 869727003268 Walker B; other site 869727003269 D-loop; other site 869727003270 H-loop/switch region; other site 869727003271 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 869727003272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869727003273 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 869727003274 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 869727003275 serine O-acetyltransferase; Region: cysE; TIGR01172 869727003276 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869727003277 trimer interface [polypeptide binding]; other site 869727003278 active site 869727003279 substrate binding site [chemical binding]; other site 869727003280 CoA binding site [chemical binding]; other site 869727003281 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 869727003282 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 869727003283 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869727003284 oligomer interface [polypeptide binding]; other site 869727003285 RNA binding site [nucleotide binding]; other site 869727003286 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 869727003287 oligomer interface [polypeptide binding]; other site 869727003288 RNA binding site [nucleotide binding]; other site 869727003289 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869727003290 putative nucleic acid binding region [nucleotide binding]; other site 869727003291 G-X-X-G motif; other site 869727003292 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869727003293 RNA binding site [nucleotide binding]; other site 869727003294 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 869727003295 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 869727003296 Organic solvent tolerance protein; Region: OstA_C; pfam04453 869727003297 Predicted membrane protein/domain [Function unknown]; Region: COG1714 869727003298 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 869727003299 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869727003300 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869727003301 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869727003302 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869727003303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869727003304 Walker A/P-loop; other site 869727003305 ATP binding site [chemical binding]; other site 869727003306 Q-loop/lid; other site 869727003307 ABC transporter signature motif; other site 869727003308 Walker B; other site 869727003309 D-loop; other site 869727003310 H-loop/switch region; other site 869727003311 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869727003312 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 869727003313 catalytic residue [active] 869727003314 putative FPP diphosphate binding site; other site 869727003315 putative FPP binding hydrophobic cleft; other site 869727003316 dimer interface [polypeptide binding]; other site 869727003317 putative IPP diphosphate binding site; other site 869727003318 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 869727003319 FAD binding domain; Region: FAD_binding_4; pfam01565 869727003320 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 869727003321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869727003322 active site residue [active] 869727003323 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 869727003324 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 869727003325 active site 869727003326 camphor resistance protein CrcB; Provisional; Region: PRK14204 869727003327 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 869727003328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727003329 FeS/SAM binding site; other site 869727003330 HemN C-terminal domain; Region: HemN_C; pfam06969 869727003331 Cytochrome c553 [Energy production and conversion]; Region: COG2863 869727003332 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 869727003333 putative active site [active] 869727003334 Ap4A binding site [chemical binding]; other site 869727003335 nudix motif; other site 869727003336 putative metal binding site [ion binding]; other site 869727003337 aspartate kinase; Reviewed; Region: PRK06635 869727003338 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 869727003339 putative nucleotide binding site [chemical binding]; other site 869727003340 putative catalytic residues [active] 869727003341 putative Mg ion binding site [ion binding]; other site 869727003342 putative aspartate binding site [chemical binding]; other site 869727003343 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 869727003344 putative allosteric regulatory site; other site 869727003345 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 869727003346 putative allosteric regulatory residue; other site 869727003347 DNA replication regulator; Region: HobA; pfam12163 869727003348 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869727003349 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 869727003350 dihydropteroate synthase; Region: DHPS; TIGR01496 869727003351 substrate binding pocket [chemical binding]; other site 869727003352 dimer interface [polypeptide binding]; other site 869727003353 inhibitor binding site; inhibition site 869727003354 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869727003355 EamA-like transporter family; Region: EamA; pfam00892 869727003356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 869727003357 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 869727003358 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 869727003359 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869727003360 catalytic site [active] 869727003361 subunit interface [polypeptide binding]; other site 869727003362 Maf-like protein; Region: Maf; pfam02545 869727003363 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 869727003364 active site 869727003365 dimer interface [polypeptide binding]; other site 869727003366 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869727003367 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869727003368 motif 1; other site 869727003369 active site 869727003370 motif 2; other site 869727003371 motif 3; other site 869727003372 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869727003373 DHHA1 domain; Region: DHHA1; pfam02272 869727003374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 869727003375 DNA polymerase III subunit delta; Validated; Region: PRK08487 869727003376 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869727003377 Exoribonuclease R [Transcription]; Region: VacB; COG0557 869727003378 RNB domain; Region: RNB; pfam00773 869727003379 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 869727003380 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869727003381 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869727003382 shikimate binding site; other site 869727003383 NAD(P) binding site [chemical binding]; other site 869727003384 Bacterial SH3 domain; Region: SH3_3; pfam08239 869727003385 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 869727003386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869727003387 dimer interface [polypeptide binding]; other site 869727003388 conserved gate region; other site 869727003389 putative PBP binding loops; other site 869727003390 ABC-ATPase subunit interface; other site 869727003391 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869727003392 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 869727003393 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869727003394 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869727003395 active site 869727003396 HIGH motif; other site 869727003397 dimer interface [polypeptide binding]; other site 869727003398 KMSKS motif; other site 869727003399 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 869727003400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727003401 S-adenosylmethionine binding site [chemical binding]; other site 869727003402 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869727003403 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869727003404 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869727003405 hinge region; other site 869727003406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869727003407 active site 869727003408 RDD family; Region: RDD; pfam06271 869727003409 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 869727003410 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 869727003411 NAD+ binding site [chemical binding]; other site 869727003412 substrate binding site [chemical binding]; other site 869727003413 Zn binding site [ion binding]; other site 869727003414 NADH dehydrogenase subunit A; Validated; Region: PRK08489 869727003415 NADH dehydrogenase subunit B; Validated; Region: PRK06411 869727003416 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 869727003417 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 869727003418 NADH dehydrogenase subunit G; Validated; Region: PRK08493 869727003419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869727003420 catalytic loop [active] 869727003421 iron binding site [ion binding]; other site 869727003422 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 869727003423 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869727003424 molybdopterin cofactor binding site; other site 869727003425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 869727003426 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 869727003427 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 869727003428 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 869727003429 4Fe-4S binding domain; Region: Fer4; cl02805 869727003430 4Fe-4S binding domain; Region: Fer4; pfam00037 869727003431 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 869727003432 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 869727003433 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 869727003434 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 869727003435 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 869727003436 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869727003437 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 869727003438 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869727003439 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 869727003440 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869727003441 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 869727003442 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869727003443 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 869727003444 active site 869727003445 substrate binding site [chemical binding]; other site 869727003446 metal binding site [ion binding]; metal-binding site 869727003447 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869727003448 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869727003449 substrate binding site [chemical binding]; other site 869727003450 active site 869727003451 catalytic residues [active] 869727003452 heterodimer interface [polypeptide binding]; other site 869727003453 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869727003454 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869727003455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869727003456 catalytic residue [active] 869727003457 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 869727003458 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869727003459 active site 869727003460 ribulose/triose binding site [chemical binding]; other site 869727003461 phosphate binding site [ion binding]; other site 869727003462 substrate (anthranilate) binding pocket [chemical binding]; other site 869727003463 product (indole) binding pocket [chemical binding]; other site 869727003464 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869727003465 active site 869727003466 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869727003467 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 869727003468 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869727003469 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869727003470 Glutamine amidotransferase class-I; Region: GATase; pfam00117 869727003471 glutamine binding [chemical binding]; other site 869727003472 catalytic triad [active] 869727003473 anthranilate synthase component I; Provisional; Region: PRK13564 869727003474 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869727003475 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869727003476 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869727003477 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869727003478 putative active site [active] 869727003479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869727003480 active site 869727003481 motif I; other site 869727003482 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869727003483 motif II; other site 869727003484 Uncharacterized conserved protein [Function unknown]; Region: COG2353 869727003485 thiaminase II; Region: salvage_TenA; TIGR04306 869727003486 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 869727003487 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869727003488 Thiamine pyrophosphokinase; Region: TPK; cd07995 869727003489 active site 869727003490 dimerization interface [polypeptide binding]; other site 869727003491 thiamine binding site [chemical binding]; other site 869727003492 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 869727003493 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869727003494 alphaNTD homodimer interface [polypeptide binding]; other site 869727003495 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 869727003496 alphaNTD - beta interaction site [polypeptide binding]; other site 869727003497 alphaNTD - beta' interaction site [polypeptide binding]; other site 869727003498 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869727003499 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869727003500 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869727003501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869727003502 RNA binding surface [nucleotide binding]; other site 869727003503 30S ribosomal protein S11; Validated; Region: PRK05309 869727003504 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 869727003505 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869727003506 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 869727003507 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869727003508 rRNA binding site [nucleotide binding]; other site 869727003509 predicted 30S ribosome binding site; other site 869727003510 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869727003511 active site 869727003512 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869727003513 SecY translocase; Region: SecY; pfam00344 869727003514 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869727003515 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 869727003516 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869727003517 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869727003518 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869727003519 23S rRNA interface [nucleotide binding]; other site 869727003520 5S rRNA interface [nucleotide binding]; other site 869727003521 L27 interface [polypeptide binding]; other site 869727003522 L5 interface [polypeptide binding]; other site 869727003523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869727003524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869727003525 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869727003526 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 869727003527 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869727003528 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869727003529 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869727003530 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869727003531 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869727003532 RNA binding site [nucleotide binding]; other site 869727003533 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869727003534 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869727003535 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869727003536 putative translocon interaction site; other site 869727003537 23S rRNA interface [nucleotide binding]; other site 869727003538 signal recognition particle (SRP54) interaction site; other site 869727003539 L23 interface [polypeptide binding]; other site 869727003540 trigger factor interaction site; other site 869727003541 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869727003542 23S rRNA interface [nucleotide binding]; other site 869727003543 5S rRNA interface [nucleotide binding]; other site 869727003544 putative antibiotic binding site [chemical binding]; other site 869727003545 L25 interface [polypeptide binding]; other site 869727003546 L27 interface [polypeptide binding]; other site 869727003547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869727003548 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869727003549 G-X-X-G motif; other site 869727003550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869727003551 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869727003552 putative translocon binding site; other site 869727003553 protein-rRNA interface [nucleotide binding]; other site 869727003554 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869727003555 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869727003556 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869727003557 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869727003558 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869727003559 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869727003560 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869727003561 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869727003562 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 869727003563 AAA domain; Region: AAA_14; pfam13173 869727003564 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869727003565 RNA/DNA hybrid binding site [nucleotide binding]; other site 869727003566 active site 869727003567 fumarate hydratase; Reviewed; Region: fumC; PRK00485 869727003568 Class II fumarases; Region: Fumarase_classII; cd01362 869727003569 active site 869727003570 tetramer interface [polypeptide binding]; other site 869727003571 YtkA-like; Region: YtkA; pfam13115 869727003572 Outer membrane efflux protein; Region: OEP; pfam02321 869727003573 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 869727003574 HlyD family secretion protein; Region: HlyD_3; pfam13437 869727003575 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 869727003576 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 869727003577 AzlC protein; Region: AzlC; cl00570 869727003578 chaperone protein DnaJ; Provisional; Region: PRK14288 869727003579 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869727003580 HSP70 interaction site [polypeptide binding]; other site 869727003581 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869727003582 substrate binding site [polypeptide binding]; other site 869727003583 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869727003584 Zn binding sites [ion binding]; other site 869727003585 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869727003586 dimer interface [polypeptide binding]; other site 869727003587 LabA_like proteins; Region: LabA_like; cd06167 869727003588 Uncharacterized conserved protein [Function unknown]; Region: COG1432 869727003589 putative metal binding site [ion binding]; other site 869727003590 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 869727003591 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869727003592 Ligand Binding Site [chemical binding]; other site 869727003593 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869727003594 HSP70 interaction site [polypeptide binding]; other site 869727003595 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869727003596 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 869727003597 active site 869727003598 (T/H)XGH motif; other site 869727003599 nickel responsive regulator; Provisional; Region: PRK00630 869727003600 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869727003601 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 869727003602 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 869727003603 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869727003604 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 869727003605 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 869727003606 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 869727003607 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 869727003608 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869727003609 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 869727003610 Cl binding site [ion binding]; other site 869727003611 oligomer interface [polypeptide binding]; other site 869727003612 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 869727003613 Phosphoglycerate kinase; Region: PGK; pfam00162 869727003614 substrate binding site [chemical binding]; other site 869727003615 hinge regions; other site 869727003616 ADP binding site [chemical binding]; other site 869727003617 catalytic site [active] 869727003618 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 869727003619 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 869727003620 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869727003621 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869727003622 ligand binding site [chemical binding]; other site 869727003623 active site 869727003624 UGI interface [polypeptide binding]; other site 869727003625 catalytic site [active] 869727003626 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869727003627 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869727003628 putative acyl-acceptor binding pocket; other site 869727003629 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 869727003630 C-terminal peptidase (prc); Region: prc; TIGR00225 869727003631 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 869727003632 protein binding site [polypeptide binding]; other site 869727003633 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 869727003634 Catalytic dyad [active] 869727003635 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869727003636 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727003637 Predicted helicase [General function prediction only]; Region: COG4889 869727003638 Predicted helicase [General function prediction only]; Region: COG4889 869727003639 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 869727003640 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869727003641 dimerization interface [polypeptide binding]; other site 869727003642 active site 869727003643 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 869727003644 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 869727003645 prenyltransferase; Reviewed; Region: ubiA; PRK12874 869727003646 UbiA prenyltransferase family; Region: UbiA; pfam01040 869727003647 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869727003648 Competence protein; Region: Competence; pfam03772 869727003649 replicative DNA helicase; Provisional; Region: PRK08506 869727003650 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869727003651 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869727003652 Walker A motif; other site 869727003653 ATP binding site [chemical binding]; other site 869727003654 Walker B motif; other site 869727003655 DNA binding loops [nucleotide binding] 869727003656 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 869727003657 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869727003658 putative substrate binding site [chemical binding]; other site 869727003659 putative ATP binding site [chemical binding]; other site 869727003660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869727003661 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 869727003662 dimer interface [polypeptide binding]; other site 869727003663 phosphorylation site [posttranslational modification] 869727003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869727003665 ATP binding site [chemical binding]; other site 869727003666 Mg2+ binding site [ion binding]; other site 869727003667 G-X-G motif; other site 869727003668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869727003669 Response regulator receiver domain; Region: Response_reg; pfam00072 869727003670 active site 869727003671 phosphorylation site [posttranslational modification] 869727003672 intermolecular recognition site; other site 869727003673 dimerization interface [polypeptide binding]; other site 869727003674 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 869727003675 DNA binding site [nucleotide binding] 869727003676 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727003677 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727003678 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727003679 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727003680 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869727003681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869727003682 ATP binding site [chemical binding]; other site 869727003683 putative Mg++ binding site [ion binding]; other site 869727003684 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869727003685 rod shape-determining protein MreC; Region: MreC; pfam04085 869727003686 rod shape-determining protein MreB; Provisional; Region: PRK13927 869727003687 MreB and similar proteins; Region: MreB_like; cd10225 869727003688 nucleotide binding site [chemical binding]; other site 869727003689 Mg binding site [ion binding]; other site 869727003690 putative protofilament interaction site [polypeptide binding]; other site 869727003691 RodZ interaction site [polypeptide binding]; other site 869727003692 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 869727003693 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 869727003694 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 869727003695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727003696 Walker A motif; other site 869727003697 ATP binding site [chemical binding]; other site 869727003698 Walker B motif; other site 869727003699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869727003700 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 869727003701 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 869727003702 active site 869727003703 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869727003704 flagellar assembly protein FliW; Provisional; Region: PRK13282 869727003705 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 869727003706 ATP-dependent protease La; Region: lon; TIGR00763 869727003707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727003708 Walker A motif; other site 869727003709 ATP binding site [chemical binding]; other site 869727003710 Walker B motif; other site 869727003711 arginine finger; other site 869727003712 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869727003713 prephenate dehydrogenase; Validated; Region: PRK08507 869727003714 Prephenate dehydrogenase; Region: PDH; pfam02153 869727003715 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 869727003716 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 869727003717 active site 869727003718 substrate binding site [chemical binding]; other site 869727003719 Mg2+ binding site [ion binding]; other site 869727003720 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 869727003721 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727003722 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727003723 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727003724 potential frameshift: common BLAST hit: gi|15612362|ref|NP_224015.1| type III restriction enzyme 869727003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 869727003726 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 869727003727 ATP binding site [chemical binding]; other site 869727003728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869727003729 putative Mg++ binding site [ion binding]; other site 869727003730 biotin synthase; Provisional; Region: PRK08508 869727003731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727003732 FeS/SAM binding site; other site 869727003733 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 869727003734 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 869727003735 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727003736 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727003737 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727003738 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727003739 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 869727003740 DHH family; Region: DHH; pfam01368 869727003741 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 869727003742 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869727003743 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869727003744 IPP transferase; Region: IPPT; pfam01715 869727003745 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869727003746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869727003747 active site 869727003748 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 869727003749 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 869727003750 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 869727003751 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869727003752 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 869727003753 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 869727003754 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 869727003755 Walker A motif/ATP binding site; other site 869727003756 Walker B motif; other site 869727003757 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 869727003758 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 869727003759 ATP binding site [chemical binding]; other site 869727003760 Walker A motif; other site 869727003761 hexamer interface [polypeptide binding]; other site 869727003762 Walker B motif; other site 869727003763 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869727003764 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869727003765 active site 869727003766 HIGH motif; other site 869727003767 nucleotide binding site [chemical binding]; other site 869727003768 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869727003769 active site 869727003770 KMSKS motif; other site 869727003771 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869727003772 tRNA binding surface [nucleotide binding]; other site 869727003773 anticodon binding site; other site 869727003774 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869727003775 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869727003776 RNA binding surface [nucleotide binding]; other site 869727003777 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869727003778 dimethyladenosine transferase; Region: ksgA; TIGR00755 869727003779 S-adenosylmethionine binding site [chemical binding]; other site 869727003780 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869727003781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869727003782 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869727003783 KpsF/GutQ family protein; Region: kpsF; TIGR00393 869727003784 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 869727003785 putative active site [active] 869727003786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 869727003787 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 869727003788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869727003789 FeS/SAM binding site; other site 869727003790 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 869727003791 active site 869727003792 carbon storage regulator; Provisional; Region: PRK00568 869727003793 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 869727003794 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869727003795 SmpB-tmRNA interface; other site 869727003796 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 869727003797 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869727003798 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 869727003799 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 869727003800 ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188 869727003801 hypothetical protein; Provisional; Region: PRK14374 869727003802 membrane protein insertase; Provisional; Region: PRK01318 869727003803 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869727003804 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869727003805 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869727003806 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 869727003807 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 869727003808 GTP/Mg2+ binding site [chemical binding]; other site 869727003809 G4 box; other site 869727003810 G5 box; other site 869727003811 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869727003812 G1 box; other site 869727003813 G1 box; other site 869727003814 GTP/Mg2+ binding site [chemical binding]; other site 869727003815 Switch I region; other site 869727003816 Switch I region; other site 869727003817 G2 box; other site 869727003818 G2 box; other site 869727003819 Switch II region; other site 869727003820 G3 box; other site 869727003821 G3 box; other site 869727003822 Switch II region; other site 869727003823 G4 box; other site 869727003824 G5 box; other site 869727003825 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869727003826 potential frameshift: common BLAST hit: gi|308183549|ref|YP_003927676.1| putative Outer membrane protein 869727003827 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003828 LPP20 lipoprotein; Region: LPP20; pfam02169 869727003829 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 869727003830 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869727003831 catalytic residues [active] 869727003832 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869727003833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869727003834 RNA binding surface [nucleotide binding]; other site 869727003835 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 869727003836 active site 869727003837 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 869727003838 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 869727003839 active site 869727003840 PHP Thumb interface [polypeptide binding]; other site 869727003841 metal binding site [ion binding]; metal-binding site 869727003842 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869727003843 generic binding surface I; other site 869727003844 generic binding surface II; other site 869727003845 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 869727003846 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 869727003847 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 869727003848 mce related protein; Region: MCE; pfam02470 869727003849 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 869727003850 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 869727003851 Walker A/P-loop; other site 869727003852 ATP binding site [chemical binding]; other site 869727003853 Q-loop/lid; other site 869727003854 ABC transporter signature motif; other site 869727003855 Walker B; other site 869727003856 D-loop; other site 869727003857 H-loop/switch region; other site 869727003858 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 869727003859 conserved hypothetical integral membrane protein; Region: TIGR00056 869727003860 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003861 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869727003862 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869727003863 homodimer interface [polypeptide binding]; other site 869727003864 substrate-cofactor binding pocket; other site 869727003865 catalytic residue [active] 869727003866 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003867 DNA polymerase I; Region: pola; TIGR00593 869727003868 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869727003869 active site 869727003870 metal binding site 1 [ion binding]; metal-binding site 869727003871 putative 5' ssDNA interaction site; other site 869727003872 metal binding site 3; metal-binding site 869727003873 metal binding site 2 [ion binding]; metal-binding site 869727003874 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869727003875 putative DNA binding site [nucleotide binding]; other site 869727003876 putative metal binding site [ion binding]; other site 869727003877 3'-5' exonuclease; Region: 35EXOc; smart00474 869727003878 active site 869727003879 substrate binding site [chemical binding]; other site 869727003880 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869727003881 active site 869727003882 DNA binding site [nucleotide binding] 869727003883 catalytic site [active] 869727003884 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869727003885 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869727003886 potential frameshift: common BLAST hit: gi|15612430|ref|NP_224083.1| type II DNA modification enzyme 869727003887 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869727003888 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 869727003889 thymidylate kinase; Validated; Region: tmk; PRK00698 869727003890 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869727003891 TMP-binding site; other site 869727003892 ATP-binding site [chemical binding]; other site 869727003893 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 869727003894 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869727003895 active site 869727003896 (T/H)XGH motif; other site 869727003897 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 869727003898 Flavoprotein; Region: Flavoprotein; pfam02441 869727003899 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 869727003900 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 869727003901 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869727003902 Part of AAA domain; Region: AAA_19; pfam13245 869727003903 Family description; Region: UvrD_C_2; pfam13538 869727003904 TPR repeat; Region: TPR_11; pfam13414 869727003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727003906 TPR motif; other site 869727003907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869727003908 binding surface 869727003909 TPR motif; other site 869727003910 seryl-tRNA synthetase; Provisional; Region: PRK05431 869727003911 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869727003912 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869727003913 dimer interface [polypeptide binding]; other site 869727003914 active site 869727003915 motif 1; other site 869727003916 motif 2; other site 869727003917 motif 3; other site 869727003918 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869727003919 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 869727003920 active site 869727003921 catalytic triad [active] 869727003922 dimer interface [polypeptide binding]; other site 869727003923 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 869727003924 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 869727003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727003926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869727003927 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 869727003928 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 869727003929 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869727003930 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 869727003931 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869727003932 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 869727003933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869727003934 HlyD family secretion protein; Region: HlyD_3; pfam13437 869727003935 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 869727003936 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869727003937 Domain of unknown function DUF21; Region: DUF21; pfam01595 869727003938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869727003939 Transporter associated domain; Region: CorC_HlyC; smart01091 869727003940 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869727003941 Phosphate transporter family; Region: PHO4; pfam01384 869727003942 NifU-like domain; Region: NifU; pfam01106 869727003943 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 869727003944 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869727003945 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869727003946 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 869727003947 putative active site [active] 869727003948 transaldolase; Provisional; Region: PRK03903 869727003949 catalytic residue [active] 869727003950 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 869727003951 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 869727003952 5S rRNA interface [nucleotide binding]; other site 869727003953 CTC domain interface [polypeptide binding]; other site 869727003954 L16 interface [polypeptide binding]; other site 869727003955 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869727003956 putative active site [active] 869727003957 catalytic residue [active] 869727003958 Predicted permeases [General function prediction only]; Region: COG0795 869727003959 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869727003960 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 869727003961 PLD-like domain; Region: PLDc_2; pfam13091 869727003962 homodimer interface [polypeptide binding]; other site 869727003963 putative active site [active] 869727003964 catalytic site [active] 869727003965 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727003966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 869727003967 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 869727003968 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 869727003969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869727003970 metal-binding site [ion binding] 869727003971 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869727003972 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869727003973 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869727003974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869727003975 S-adenosylmethionine binding site [chemical binding]; other site 869727003976 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869727003977 catalytic motif [active] 869727003978 Zn binding site [ion binding]; other site 869727003979 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 869727003980 RibD C-terminal domain; Region: RibD_C; cl17279 869727003981 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 869727003982 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869727003983 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 869727003984 4Fe-4S binding domain; Region: Fer4_5; pfam12801 869727003985 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 869727003986 acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023 869727003987 FolB domain; Region: folB_dom; TIGR00526 869727003988 active site 869727003989 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 869727003990 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 869727003991 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869727003992 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 869727003993 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 869727003994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869727003995 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 869727003996 NusA N-terminal domain; Region: NusA_N; pfam08529 869727003997 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869727003998 RNA binding site [nucleotide binding]; other site 869727003999 homodimer interface [polypeptide binding]; other site 869727004000 NusA-like KH domain; Region: KH_5; pfam13184 869727004001 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869727004002 G-X-X-G motif; other site 869727004003 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 869727004004 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 869727004005 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 869727004006 Restriction endonuclease [Defense mechanisms]; Region: COG3587 869727004007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727004008 ATP binding site [chemical binding]; other site 869727004009 putative Mg++ binding site [ion binding]; other site 869727004010 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727004011 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869727004012 DNA methylase; Region: N6_N4_Mtase; pfam01555 869727004013 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 869727004014 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869727004015 ssDNA binding site; other site 869727004016 generic binding surface II; other site 869727004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727004018 ATP binding site [chemical binding]; other site 869727004019 putative Mg++ binding site [ion binding]; other site 869727004020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727004021 nucleotide binding region [chemical binding]; other site 869727004022 ATP-binding site [chemical binding]; other site 869727004023 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727004024 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 869727004025 active site 869727004026 putative catalytic site [active] 869727004027 DNA binding site [nucleotide binding] 869727004028 putative phosphate binding site [ion binding]; other site 869727004029 metal binding site A [ion binding]; metal-binding site 869727004030 AP binding site [nucleotide binding]; other site 869727004031 metal binding site B [ion binding]; metal-binding site 869727004032 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 869727004033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869727004034 Walker A motif; other site 869727004035 ATP binding site [chemical binding]; other site 869727004036 Walker B motif; other site 869727004037 arginine finger; other site 869727004038 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869727004039 DnaA box-binding interface [nucleotide binding]; other site 869727004040 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 869727004041 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 869727004042 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 869727004043 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869727004044 glutaminase active site [active] 869727004045 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869727004046 dimer interface [polypeptide binding]; other site 869727004047 active site 869727004048 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869727004049 dimer interface [polypeptide binding]; other site 869727004050 active site 869727004051 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 869727004052 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869727004053 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869727004054 potential frameshift: common BLAST hit: gi|254780040|ref|YP_003058147.1| type I restriction-modification enzyme subunit M 869727004055 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 869727004056 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869727004057 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869727004058 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 869727004059 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869727004060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727004061 ATP binding site [chemical binding]; other site 869727004062 putative Mg++ binding site [ion binding]; other site 869727004063 Protein of unknown function DUF45; Region: DUF45; pfam01863 869727004064 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 869727004065 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869727004066 N-terminal plug; other site 869727004067 ligand-binding site [chemical binding]; other site 869727004068 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 869727004069 Arginase family; Region: Arginase; cd09989 869727004070 active site 869727004071 Mn binding site [ion binding]; other site 869727004072 oligomer interface [polypeptide binding]; other site 869727004073 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 869727004074 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 869727004075 hexamer interface [polypeptide binding]; other site 869727004076 ligand binding site [chemical binding]; other site 869727004077 putative active site [active] 869727004078 NAD(P) binding site [chemical binding]; other site 869727004079 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 869727004080 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 869727004081 putative NAD(P) binding site [chemical binding]; other site 869727004082 putative substrate binding site [chemical binding]; other site 869727004083 catalytic Zn binding site [ion binding]; other site 869727004084 structural Zn binding site [ion binding]; other site 869727004085 dimer interface [polypeptide binding]; other site 869727004086 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727004087 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727004088 Protein of unknown function DUF262; Region: DUF262; pfam03235 869727004089 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869727004090 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869727004091 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 869727004092 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 869727004093 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869727004094 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869727004095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869727004096 Walker A/P-loop; other site 869727004097 ATP binding site [chemical binding]; other site 869727004098 Q-loop/lid; other site 869727004099 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869727004100 ABC transporter signature motif; other site 869727004101 Walker B; other site 869727004102 D-loop; other site 869727004103 H-loop/switch region; other site 869727004104 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869727004105 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869727004106 Transposase IS200 like; Region: Y1_Tnp; pfam01797 869727004107 potential frameshift: common BLAST hit: gi|15611893|ref|NP_223544.1| IS606 transposase 869727004108 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 869727004109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 869727004110 Probable transposase; Region: OrfB_IS605; pfam01385 869727004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 869727004112 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 869727004113 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869727004114 active site 869727004115 catalytic site [active] 869727004116 substrate binding site [chemical binding]; other site 869727004117 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869727004118 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 869727004119 substrate binding site [chemical binding]; other site 869727004120 hexamer interface [polypeptide binding]; other site 869727004121 metal binding site [ion binding]; metal-binding site 869727004122 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 869727004123 active site 869727004124 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869727004125 elongation factor Ts; Provisional; Region: tsf; PRK09377 869727004126 UBA/TS-N domain; Region: UBA; pfam00627 869727004127 Elongation factor TS; Region: EF_TS; pfam00889 869727004128 Elongation factor TS; Region: EF_TS; pfam00889 869727004129 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869727004130 rRNA interaction site [nucleotide binding]; other site 869727004131 S8 interaction site; other site 869727004132 putative laminin-1 binding site; other site 869727004133 putative recombination protein RecB; Provisional; Region: PRK13909 869727004134 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 869727004135 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856 869727004136 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 869727004137 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 869727004138 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 869727004139 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 869727004140 Protein export membrane protein; Region: SecD_SecF; pfam02355 869727004141 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869727004142 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869727004143 HIGH motif; other site 869727004144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869727004145 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869727004146 active site 869727004147 KMSKS motif; other site 869727004148 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869727004149 tRNA binding surface [nucleotide binding]; other site 869727004150 anticodon binding site; other site 869727004151 Lipopolysaccharide-assembly; Region: LptE; pfam04390 869727004152 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869727004153 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869727004154 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869727004155 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869727004156 Peptidase family M23; Region: Peptidase_M23; pfam01551 869727004157 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869727004158 Peptidase family M23; Region: Peptidase_M23; pfam01551 869727004159 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 869727004160 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 869727004161 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 869727004162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869727004163 ATP binding site [chemical binding]; other site 869727004164 putative Mg++ binding site [ion binding]; other site 869727004165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869727004166 nucleotide binding region [chemical binding]; other site 869727004167 ATP-binding site [chemical binding]; other site 869727004168 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869727004169 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 869727004170 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 869727004171 [2Fe-2S] cluster binding site [ion binding]; other site 869727004172 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 869727004173 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 869727004174 intrachain domain interface; other site 869727004175 interchain domain interface [polypeptide binding]; other site 869727004176 heme bH binding site [chemical binding]; other site 869727004177 Qi binding site; other site 869727004178 heme bL binding site [chemical binding]; other site 869727004179 Qo binding site; other site 869727004180 interchain domain interface [polypeptide binding]; other site 869727004181 intrachain domain interface; other site 869727004182 Qi binding site; other site 869727004183 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 869727004184 Qo binding site; other site 869727004185 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 869727004186 Cytochrome c; Region: Cytochrom_C; pfam00034 869727004187 Cytochrome c; Region: Cytochrom_C; cl11414 869727004188 potential frameshift: common BLAST hit: gi|315454048|ref|YP_004074318.1| sulfatase 869727004189 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 869727004190 Sulfatase; Region: Sulfatase; cl17466 869727004191 Sulfatase; Region: Sulfatase; cl17466 869727004192 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869727004193 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869727004194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869727004195 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 869727004196 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 869727004197 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869727004198 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 869727004199 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 869727004200 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 869727004201 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869727004202 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869727004203 intersubunit interface [polypeptide binding]; other site 869727004204 potential frameshift: common BLAST hit: gi|208435441|ref|YP_002267107.1| iron (III) ABC transporter periplasmic iron-bindin gprotein 869727004205 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869727004206 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869727004207 intersubunit interface [polypeptide binding]; other site 869727004208 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 869727004209 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 869727004210 dimer interface [polypeptide binding]; other site 869727004211 decamer (pentamer of dimers) interface [polypeptide binding]; other site 869727004212 catalytic triad [active] 869727004213 peroxidatic and resolving cysteines [active] 869727004214 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869727004215 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869727004216 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 869727004217 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869727004218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869727004219 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869727004220 G1 box; other site 869727004221 GTP/Mg2+ binding site [chemical binding]; other site 869727004222 Switch I region; other site 869727004223 G2 box; other site 869727004224 G3 box; other site 869727004225 Switch II region; other site 869727004226 G4 box; other site 869727004227 G5 box; other site 869727004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 869727004229 OstA-like protein; Region: OstA; pfam03968 869727004230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869727004231 motif II; other site 869727004232 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 869727004233 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 869727004234 Sporulation related domain; Region: SPOR; pfam05036 869727004235 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869727004236 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869727004237 catalytic residue [active] 869727004238 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869727004239 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869727004240 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869727004241 active site 869727004242 riboflavin synthase, alpha subunit; Region: ribE; TIGR00187 869727004243 Lumazine binding domain; Region: Lum_binding; pfam00677 869727004244 Lumazine binding domain; Region: Lum_binding; pfam00677 869727004245 flhB C-terminus-related protein; Region: flhB_rel; TIGR00789 869727004246 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 869727004247 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869727004248 Walker A/P-loop; other site 869727004249 ATP binding site [chemical binding]; other site 869727004250 Q-loop/lid; other site 869727004251 ABC transporter signature motif; other site 869727004252 Walker B; other site 869727004253 D-loop; other site 869727004254 H-loop/switch region; other site 869727004255 NIL domain; Region: NIL; pfam09383 869727004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869727004257 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869727004258 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 869727004259 active site 869727004260 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 869727004261 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 869727004262 Mg++ binding site [ion binding]; other site 869727004263 putative catalytic motif [active] 869727004264 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 869727004265 active site 869727004266 hydrophilic channel; other site 869727004267 dimerization interface [polypeptide binding]; other site 869727004268 catalytic residues [active] 869727004269 active site lid [active] 869727004270 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 869727004271 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 869727004272 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 869727004273 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 869727004274 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 869727004275 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869727004276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869727004277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 869727004278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 869727004279 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 869727004280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735