-- dump date 20140619_113206 -- class Genbank::misc_feature -- table misc_feature_note -- id note 866345000001 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 866345000002 putative RNA binding site [nucleotide binding]; other site 866345000003 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 866345000004 homopentamer interface [polypeptide binding]; other site 866345000005 active site 866345000006 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 866345000007 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 866345000008 active site clefts [active] 866345000009 zinc binding site [ion binding]; other site 866345000010 dimer interface [polypeptide binding]; other site 866345000011 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 866345000012 active site 866345000013 dimer interface [polypeptide binding]; other site 866345000014 pantoate--beta-alanine ligase; Region: panC; TIGR00018 866345000015 Pantoate-beta-alanine ligase; Region: PanC; cd00560 866345000016 active site 866345000017 ATP-binding site [chemical binding]; other site 866345000018 pantoate-binding site; other site 866345000019 HXXH motif; other site 866345000020 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000021 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 866345000022 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 866345000023 ring oligomerisation interface [polypeptide binding]; other site 866345000024 ATP/Mg binding site [chemical binding]; other site 866345000025 stacking interactions; other site 866345000026 hinge regions; other site 866345000027 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 866345000028 oligomerisation interface [polypeptide binding]; other site 866345000029 mobile loop; other site 866345000030 roof hairpin; other site 866345000031 DNA primase, catalytic core; Region: dnaG; TIGR01391 866345000032 CHC2 zinc finger; Region: zf-CHC2; pfam01807 866345000033 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 866345000034 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 866345000035 active site 866345000036 metal binding site [ion binding]; metal-binding site 866345000037 interdomain interaction site; other site 866345000038 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 866345000039 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 866345000040 Ligand Binding Site [chemical binding]; other site 866345000041 TrbC/VIRB2 family; Region: TrbC; cl01583 866345000042 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 866345000043 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 866345000044 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 866345000045 Walker A motif; other site 866345000046 ATP binding site [chemical binding]; other site 866345000047 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 866345000048 Walker B motif; other site 866345000049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 866345000050 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 866345000051 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866345000052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345000053 active site 866345000054 phosphorylation site [posttranslational modification] 866345000055 intermolecular recognition site; other site 866345000056 dimerization interface [polypeptide binding]; other site 866345000057 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 866345000058 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 866345000059 dimer interface [polypeptide binding]; other site 866345000060 active site 866345000061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866345000062 catalytic residues [active] 866345000063 substrate binding site [chemical binding]; other site 866345000064 lipid A 1-phosphatase; Reviewed; Region: PRK09597 866345000065 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 866345000066 active site 866345000067 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 866345000068 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 866345000069 Sulfatase; Region: Sulfatase; pfam00884 866345000070 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000071 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 866345000072 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 866345000073 prephenate dehydrogenase; Validated; Region: PRK08507 866345000074 Prephenate dehydrogenase; Region: PDH; pfam02153 866345000075 ATP-dependent protease La; Region: lon; TIGR00763 866345000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345000077 Walker A motif; other site 866345000078 ATP binding site [chemical binding]; other site 866345000079 Walker B motif; other site 866345000080 arginine finger; other site 866345000081 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 866345000082 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 866345000083 flagellar assembly protein FliW; Provisional; Region: PRK13282 866345000084 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 866345000085 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 866345000086 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 866345000087 active site 866345000088 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 866345000089 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 866345000090 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 866345000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345000092 Walker A motif; other site 866345000093 ATP binding site [chemical binding]; other site 866345000094 Walker B motif; other site 866345000095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 866345000096 rod shape-determining protein MreB; Provisional; Region: PRK13927 866345000097 MreB and similar proteins; Region: MreB_like; cd10225 866345000098 nucleotide binding site [chemical binding]; other site 866345000099 Mg binding site [ion binding]; other site 866345000100 putative protofilament interaction site [polypeptide binding]; other site 866345000101 RodZ interaction site [polypeptide binding]; other site 866345000102 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 866345000103 rod shape-determining protein MreC; Region: MreC; pfam04085 866345000104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866345000105 DEAD-like helicases superfamily; Region: DEXDc; smart00487 866345000106 ATP binding site [chemical binding]; other site 866345000107 putative Mg++ binding site [ion binding]; other site 866345000108 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866345000109 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345000110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866345000111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345000112 active site 866345000113 phosphorylation site [posttranslational modification] 866345000114 intermolecular recognition site; other site 866345000115 dimerization interface [polypeptide binding]; other site 866345000116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866345000117 DNA binding site [nucleotide binding] 866345000118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866345000119 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 866345000120 dimer interface [polypeptide binding]; other site 866345000121 phosphorylation site [posttranslational modification] 866345000122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345000123 ATP binding site [chemical binding]; other site 866345000124 Mg2+ binding site [ion binding]; other site 866345000125 G-X-G motif; other site 866345000126 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 866345000127 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 866345000128 putative substrate binding site [chemical binding]; other site 866345000129 putative ATP binding site [chemical binding]; other site 866345000130 replicative DNA helicase; Provisional; Region: PRK08506 866345000131 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 866345000132 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 866345000133 Walker A motif; other site 866345000134 ATP binding site [chemical binding]; other site 866345000135 Walker B motif; other site 866345000136 DNA binding loops [nucleotide binding] 866345000137 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 866345000138 Competence protein; Region: Competence; pfam03772 866345000139 prenyltransferase; Reviewed; Region: ubiA; PRK12874 866345000140 UbiA prenyltransferase family; Region: UbiA; pfam01040 866345000141 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 866345000142 Quinolinate synthetase A protein; Region: NadA; cl00420 866345000143 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 866345000144 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 866345000145 dimerization interface [polypeptide binding]; other site 866345000146 active site 866345000147 potential frameshift: common BLAST hit: gi|15645966|ref|NP_208146.1| adenine-specific DNA methyltransferase 866345000148 Predicted helicase [General function prediction only]; Region: COG4889 866345000149 potential frameshift: common BLAST hit: gi|108563726|ref|YP_628042.1| adenine specific DNA methyltransferase 866345000150 Predicted helicase [General function prediction only]; Region: COG4889 866345000151 Predicted helicase [General function prediction only]; Region: COG4889 866345000152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866345000153 C-terminal peptidase (prc); Region: prc; TIGR00225 866345000154 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 866345000155 protein binding site [polypeptide binding]; other site 866345000156 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 866345000157 Catalytic dyad [active] 866345000158 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 866345000159 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866345000160 putative acyl-acceptor binding pocket; other site 866345000161 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 866345000162 ligand binding site [chemical binding]; other site 866345000163 active site 866345000164 UGI interface [polypeptide binding]; other site 866345000165 catalytic site [active] 866345000166 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 866345000167 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 866345000168 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 866345000169 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 866345000170 Phosphoglycerate kinase; Region: PGK; pfam00162 866345000171 substrate binding site [chemical binding]; other site 866345000172 hinge regions; other site 866345000173 ADP binding site [chemical binding]; other site 866345000174 catalytic site [active] 866345000175 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 866345000176 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 866345000177 Cl binding site [ion binding]; other site 866345000178 oligomer interface [polypeptide binding]; other site 866345000179 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 866345000180 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345000181 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 866345000182 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 866345000183 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 866345000184 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 866345000185 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 866345000186 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 866345000187 nickel responsive regulator; Provisional; Region: PRK00630 866345000188 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 866345000189 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 866345000190 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 866345000191 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 866345000192 active site 866345000193 (T/H)XGH motif; other site 866345000194 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 866345000195 HSP70 interaction site [polypeptide binding]; other site 866345000196 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 866345000197 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 866345000198 Ligand Binding Site [chemical binding]; other site 866345000199 Uncharacterized conserved protein [Function unknown]; Region: COG1432 866345000200 LabA_like proteins; Region: LabA_like; cd06167 866345000201 putative metal binding site [ion binding]; other site 866345000202 chaperone protein DnaJ; Provisional; Region: PRK14288 866345000203 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 866345000204 HSP70 interaction site [polypeptide binding]; other site 866345000205 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 866345000206 substrate binding site [polypeptide binding]; other site 866345000207 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 866345000208 Zn binding sites [ion binding]; other site 866345000209 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 866345000210 substrate binding site [polypeptide binding]; other site 866345000211 dimer interface [polypeptide binding]; other site 866345000212 AzlC protein; Region: AzlC; cl00570 866345000213 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 866345000214 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 866345000215 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 866345000216 HlyD family secretion protein; Region: HlyD_3; pfam13437 866345000217 Outer membrane efflux protein; Region: OEP; pfam02321 866345000218 YtkA-like; Region: YtkA; pfam13115 866345000219 fumarate hydratase; Reviewed; Region: fumC; PRK00485 866345000220 Class II fumarases; Region: Fumarase_classII; cd01362 866345000221 active site 866345000222 tetramer interface [polypeptide binding]; other site 866345000223 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 866345000224 RNA/DNA hybrid binding site [nucleotide binding]; other site 866345000225 active site 866345000226 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 866345000227 AAA domain; Region: AAA_14; pfam13173 866345000228 Helix-turn-helix domain; Region: HTH_36; pfam13730 866345000229 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 866345000230 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 866345000231 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 866345000232 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 866345000233 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 866345000234 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 866345000235 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 866345000236 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 866345000237 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 866345000238 putative translocon binding site; other site 866345000239 protein-rRNA interface [nucleotide binding]; other site 866345000240 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 866345000241 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 866345000242 G-X-X-G motif; other site 866345000243 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 866345000244 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 866345000245 23S rRNA interface [nucleotide binding]; other site 866345000246 5S rRNA interface [nucleotide binding]; other site 866345000247 putative antibiotic binding site [chemical binding]; other site 866345000248 L25 interface [polypeptide binding]; other site 866345000249 L27 interface [polypeptide binding]; other site 866345000250 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 866345000251 putative translocon interaction site; other site 866345000252 23S rRNA interface [nucleotide binding]; other site 866345000253 signal recognition particle (SRP54) interaction site; other site 866345000254 L23 interface [polypeptide binding]; other site 866345000255 trigger factor interaction site; other site 866345000256 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 866345000257 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 866345000258 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 866345000259 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 866345000260 RNA binding site [nucleotide binding]; other site 866345000261 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 866345000262 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 866345000263 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 866345000264 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 866345000265 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 866345000266 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 866345000267 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 866345000268 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 866345000269 23S rRNA interface [nucleotide binding]; other site 866345000270 5S rRNA interface [nucleotide binding]; other site 866345000271 L27 interface [polypeptide binding]; other site 866345000272 L5 interface [polypeptide binding]; other site 866345000273 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 866345000274 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 866345000275 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 866345000276 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 866345000277 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 866345000278 SecY translocase; Region: SecY; pfam00344 866345000279 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 866345000280 active site 866345000281 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 866345000282 rRNA binding site [nucleotide binding]; other site 866345000283 predicted 30S ribosome binding site; other site 866345000284 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 866345000285 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 866345000286 30S ribosomal protein S13; Region: bact_S13; TIGR03631 866345000287 30S ribosomal protein S11; Validated; Region: PRK05309 866345000288 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 866345000289 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 866345000290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866345000291 RNA binding surface [nucleotide binding]; other site 866345000292 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 866345000293 alphaNTD homodimer interface [polypeptide binding]; other site 866345000294 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 866345000295 alphaNTD - beta interaction site [polypeptide binding]; other site 866345000296 alphaNTD - beta' interaction site [polypeptide binding]; other site 866345000297 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 866345000298 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 866345000299 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 866345000300 Thiamine pyrophosphokinase; Region: TPK; cd07995 866345000301 active site 866345000302 dimerization interface [polypeptide binding]; other site 866345000303 thiamine binding site [chemical binding]; other site 866345000304 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 866345000305 thiaminase II; Region: salvage_TenA; TIGR04306 866345000306 Uncharacterized conserved protein [Function unknown]; Region: COG2353 866345000307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866345000308 active site 866345000309 motif I; other site 866345000310 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 866345000311 motif II; other site 866345000312 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 866345000313 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 866345000314 putative active site [active] 866345000315 anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565 866345000316 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 866345000317 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 866345000318 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 866345000319 Glutamine amidotransferase class-I; Region: GATase; pfam00117 866345000320 glutamine binding [chemical binding]; other site 866345000321 catalytic triad [active] 866345000322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 866345000323 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 866345000324 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 866345000325 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 866345000326 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 866345000327 active site 866345000328 ribulose/triose binding site [chemical binding]; other site 866345000329 phosphate binding site [ion binding]; other site 866345000330 substrate (anthranilate) binding pocket [chemical binding]; other site 866345000331 product (indole) binding pocket [chemical binding]; other site 866345000332 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 866345000333 active site 866345000334 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 866345000335 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 866345000336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345000337 catalytic residue [active] 866345000338 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 866345000339 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 866345000340 substrate binding site [chemical binding]; other site 866345000341 active site 866345000342 catalytic residues [active] 866345000343 heterodimer interface [polypeptide binding]; other site 866345000344 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 866345000345 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 866345000346 active site 866345000347 substrate binding site [chemical binding]; other site 866345000348 metal binding site [ion binding]; metal-binding site 866345000349 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 866345000350 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866345000351 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 866345000352 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866345000353 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 866345000354 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 866345000355 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866345000356 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 866345000357 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 866345000358 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 866345000359 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 866345000360 4Fe-4S binding domain; Region: Fer4; cl02805 866345000361 4Fe-4S binding domain; Region: Fer4; pfam00037 866345000362 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 866345000363 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 866345000364 NADH dehydrogenase subunit G; Validated; Region: PRK08493 866345000365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866345000366 catalytic loop [active] 866345000367 iron binding site [ion binding]; other site 866345000368 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 866345000369 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345000370 molybdopterin cofactor binding site; other site 866345000371 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 866345000372 NADH dehydrogenase subunit D; Validated; Region: PRK06075 866345000373 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 866345000374 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 866345000375 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 866345000376 NADH dehydrogenase subunit B; Validated; Region: PRK06411 866345000377 NADH dehydrogenase subunit A; Validated; Region: PRK08489 866345000378 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 866345000379 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 866345000380 NAD+ binding site [chemical binding]; other site 866345000381 substrate binding site [chemical binding]; other site 866345000382 Zn binding site [ion binding]; other site 866345000383 RDD family; Region: RDD; pfam06271 866345000384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866345000385 active site 866345000386 ribosome recycling factor; Reviewed; Region: frr; PRK00083 866345000387 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 866345000388 hinge region; other site 866345000389 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 866345000390 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 866345000391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345000392 S-adenosylmethionine binding site [chemical binding]; other site 866345000393 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 866345000394 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 866345000395 active site 866345000396 HIGH motif; other site 866345000397 dimer interface [polypeptide binding]; other site 866345000398 KMSKS motif; other site 866345000399 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 866345000400 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 866345000401 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 866345000402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345000403 dimer interface [polypeptide binding]; other site 866345000404 conserved gate region; other site 866345000405 putative PBP binding loops; other site 866345000406 ABC-ATPase subunit interface; other site 866345000407 Bacterial SH3 domain; Region: SH3_3; pfam08239 866345000408 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 866345000409 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 866345000410 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 866345000411 shikimate binding site; other site 866345000412 NAD(P) binding site [chemical binding]; other site 866345000413 Exoribonuclease R [Transcription]; Region: VacB; COG0557 866345000414 RNB domain; Region: RNB; pfam00773 866345000415 DNA polymerase III subunit delta; Validated; Region: PRK08487 866345000416 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 866345000417 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 866345000418 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 866345000419 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 866345000420 dimer interface [polypeptide binding]; other site 866345000421 ssDNA binding site [nucleotide binding]; other site 866345000422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 866345000423 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 866345000424 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 866345000426 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 866345000427 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 866345000428 motif 1; other site 866345000429 active site 866345000430 motif 2; other site 866345000431 motif 3; other site 866345000432 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 866345000433 Maf-like protein; Region: Maf; pfam02545 866345000434 Maf-like protein; Reviewed; Region: PRK04056 866345000435 putative active site [active] 866345000436 formamidase; Provisional; Region: amiF; PRK13287 866345000437 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 866345000438 multimer interface [polypeptide binding]; other site 866345000439 active site 866345000440 catalytic triad [active] 866345000441 dimer interface [polypeptide binding]; other site 866345000442 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 866345000443 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 866345000444 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 866345000445 catalytic site [active] 866345000446 subunit interface [polypeptide binding]; other site 866345000447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 866345000448 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 866345000449 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 866345000450 EamA-like transporter family; Region: EamA; pfam00892 866345000451 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 866345000452 dihydropteroate synthase; Region: DHPS; TIGR01496 866345000453 substrate binding pocket [chemical binding]; other site 866345000454 dimer interface [polypeptide binding]; other site 866345000455 inhibitor binding site; inhibition site 866345000456 DNA polymerase III subunit delta'; Validated; Region: PRK08485 866345000457 DNA replication regulator; Region: HobA; pfam12163 866345000458 aspartate kinase; Reviewed; Region: PRK06635 866345000459 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 866345000460 putative nucleotide binding site [chemical binding]; other site 866345000461 putative catalytic residues [active] 866345000462 putative Mg ion binding site [ion binding]; other site 866345000463 putative aspartate binding site [chemical binding]; other site 866345000464 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 866345000465 putative allosteric regulatory site; other site 866345000466 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 866345000467 putative allosteric regulatory residue; other site 866345000468 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 866345000469 putative active site [active] 866345000470 Ap4A binding site [chemical binding]; other site 866345000471 nudix motif; other site 866345000472 putative metal binding site [ion binding]; other site 866345000473 Cytochrome c553 [Energy production and conversion]; Region: COG2863 866345000474 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 866345000475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345000476 FeS/SAM binding site; other site 866345000477 HemN C-terminal domain; Region: HemN_C; pfam06969 866345000478 camphor resistance protein CrcB; Provisional; Region: PRK14204 866345000479 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 866345000480 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 866345000481 active site 866345000482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866345000483 active site residue [active] 866345000484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 866345000485 FAD binding domain; Region: FAD_binding_4; pfam01565 866345000486 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 866345000487 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 866345000488 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 866345000489 catalytic residue [active] 866345000490 putative FPP diphosphate binding site; other site 866345000491 putative FPP binding hydrophobic cleft; other site 866345000492 dimer interface [polypeptide binding]; other site 866345000493 putative IPP diphosphate binding site; other site 866345000494 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 866345000495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866345000496 Walker A/P-loop; other site 866345000497 ATP binding site [chemical binding]; other site 866345000498 Q-loop/lid; other site 866345000499 ABC transporter signature motif; other site 866345000500 Walker B; other site 866345000501 D-loop; other site 866345000502 H-loop/switch region; other site 866345000503 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 866345000504 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 866345000505 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 866345000506 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 866345000507 Predicted membrane protein/domain [Function unknown]; Region: COG1714 866345000508 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 866345000509 Organic solvent tolerance protein; Region: OstA_C; pfam04453 866345000510 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 866345000511 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 866345000512 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 866345000513 oligomer interface [polypeptide binding]; other site 866345000514 RNA binding site [nucleotide binding]; other site 866345000515 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 866345000516 oligomer interface [polypeptide binding]; other site 866345000517 RNA binding site [nucleotide binding]; other site 866345000518 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 866345000519 putative nucleic acid binding region [nucleotide binding]; other site 866345000520 G-X-X-G motif; other site 866345000521 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 866345000522 RNA binding site [nucleotide binding]; other site 866345000523 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 866345000524 serine O-acetyltransferase; Region: cysE; TIGR01172 866345000525 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 866345000526 trimer interface [polypeptide binding]; other site 866345000527 active site 866345000528 substrate binding site [chemical binding]; other site 866345000529 CoA binding site [chemical binding]; other site 866345000530 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 866345000531 active site 866345000532 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 866345000533 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 866345000534 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 866345000535 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 866345000536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866345000537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345000538 Walker A/P-loop; other site 866345000539 ATP binding site [chemical binding]; other site 866345000540 Q-loop/lid; other site 866345000541 ABC transporter signature motif; other site 866345000542 Walker B; other site 866345000543 D-loop; other site 866345000544 H-loop/switch region; other site 866345000545 elongation factor Tu; Reviewed; Region: PRK00049 866345000546 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 866345000547 G1 box; other site 866345000548 GEF interaction site [polypeptide binding]; other site 866345000549 GTP/Mg2+ binding site [chemical binding]; other site 866345000550 Switch I region; other site 866345000551 G2 box; other site 866345000552 G3 box; other site 866345000553 Switch II region; other site 866345000554 G4 box; other site 866345000555 G5 box; other site 866345000556 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 866345000557 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 866345000558 Antibiotic Binding Site [chemical binding]; other site 866345000559 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 866345000560 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 866345000561 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 866345000562 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 866345000563 putative homodimer interface [polypeptide binding]; other site 866345000564 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 866345000565 heterodimer interface [polypeptide binding]; other site 866345000566 homodimer interface [polypeptide binding]; other site 866345000567 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 866345000568 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 866345000569 23S rRNA interface [nucleotide binding]; other site 866345000570 L7/L12 interface [polypeptide binding]; other site 866345000571 putative thiostrepton binding site; other site 866345000572 L25 interface [polypeptide binding]; other site 866345000573 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 866345000574 mRNA/rRNA interface [nucleotide binding]; other site 866345000575 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 866345000576 23S rRNA interface [nucleotide binding]; other site 866345000577 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 866345000578 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 866345000579 core dimer interface [polypeptide binding]; other site 866345000580 peripheral dimer interface [polypeptide binding]; other site 866345000581 L10 interface [polypeptide binding]; other site 866345000582 L11 interface [polypeptide binding]; other site 866345000583 putative EF-Tu interaction site [polypeptide binding]; other site 866345000584 putative EF-G interaction site [polypeptide binding]; other site 866345000585 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 866345000586 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 866345000587 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 866345000588 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 866345000589 RPB11 interaction site [polypeptide binding]; other site 866345000590 RPB12 interaction site [polypeptide binding]; other site 866345000591 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 866345000592 RPB3 interaction site [polypeptide binding]; other site 866345000593 RPB1 interaction site [polypeptide binding]; other site 866345000594 RPB11 interaction site [polypeptide binding]; other site 866345000595 RPB10 interaction site [polypeptide binding]; other site 866345000596 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 866345000597 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 866345000598 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 866345000599 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 866345000600 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 866345000601 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 866345000602 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 866345000603 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 866345000604 DNA binding site [nucleotide binding] 866345000605 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 866345000606 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 866345000607 S17 interaction site [polypeptide binding]; other site 866345000608 S8 interaction site; other site 866345000609 16S rRNA interaction site [nucleotide binding]; other site 866345000610 streptomycin interaction site [chemical binding]; other site 866345000611 23S rRNA interaction site [nucleotide binding]; other site 866345000612 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 866345000613 30S ribosomal protein S7; Validated; Region: PRK05302 866345000614 elongation factor G; Reviewed; Region: PRK00007 866345000615 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 866345000616 G1 box; other site 866345000617 putative GEF interaction site [polypeptide binding]; other site 866345000618 GTP/Mg2+ binding site [chemical binding]; other site 866345000619 Switch I region; other site 866345000620 G2 box; other site 866345000621 G3 box; other site 866345000622 Switch II region; other site 866345000623 G4 box; other site 866345000624 G5 box; other site 866345000625 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 866345000626 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 866345000627 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 866345000628 electron transport complex protein RnfC; Provisional; Region: PRK05035 866345000629 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 866345000630 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 866345000631 putative active site [active] 866345000632 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 866345000633 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 866345000634 dimer interface [polypeptide binding]; other site 866345000635 motif 1; other site 866345000636 active site 866345000637 motif 2; other site 866345000638 motif 3; other site 866345000639 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 866345000640 anticodon binding site; other site 866345000641 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 866345000642 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 866345000643 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 866345000644 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 866345000645 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 866345000646 active site 866345000647 zinc binding site [ion binding]; other site 866345000648 putative arabinose transporter; Provisional; Region: PRK03545 866345000649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345000650 putative substrate translocation pore; other site 866345000651 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 866345000652 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 866345000653 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 866345000654 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 866345000655 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 866345000656 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 866345000657 Ligand Binding Site [chemical binding]; other site 866345000658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345000659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866345000660 putative substrate translocation pore; other site 866345000661 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 866345000662 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 866345000663 Nucleoside recognition; Region: Gate; pfam07670 866345000664 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 866345000665 phosphopentomutase; Provisional; Region: PRK05362 866345000666 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 866345000667 purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107 866345000668 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000669 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 866345000670 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 866345000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345000672 putative substrate translocation pore; other site 866345000673 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 866345000674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 866345000675 substrate binding pocket [chemical binding]; other site 866345000676 membrane-bound complex binding site; other site 866345000677 hinge residues; other site 866345000678 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 866345000679 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 866345000680 Walker A/P-loop; other site 866345000681 ATP binding site [chemical binding]; other site 866345000682 Q-loop/lid; other site 866345000683 ABC transporter signature motif; other site 866345000684 Walker B; other site 866345000685 D-loop; other site 866345000686 H-loop/switch region; other site 866345000687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345000688 dimer interface [polypeptide binding]; other site 866345000689 conserved gate region; other site 866345000690 putative PBP binding loops; other site 866345000691 ABC-ATPase subunit interface; other site 866345000692 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 866345000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345000694 dimer interface [polypeptide binding]; other site 866345000695 conserved gate region; other site 866345000696 putative PBP binding loops; other site 866345000697 ABC-ATPase subunit interface; other site 866345000698 carbon starvation protein A; Provisional; Region: PRK15015 866345000699 Carbon starvation protein CstA; Region: CstA; pfam02554 866345000700 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 866345000701 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345000702 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 866345000703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 866345000704 active site 866345000705 dimer interface [polypeptide binding]; other site 866345000706 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 866345000707 dimer interface [polypeptide binding]; other site 866345000708 active site 866345000709 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 866345000710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866345000711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866345000712 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 866345000713 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 866345000714 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 866345000715 flavodoxin FldA; Validated; Region: PRK09267 866345000716 metal-binding heat shock protein; Provisional; Region: PRK00016 866345000717 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 866345000718 Fic/DOC family; Region: Fic; cl00960 866345000719 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 866345000720 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 866345000721 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000722 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000723 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 866345000724 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 866345000725 active site 866345000726 homodimer interface [polypeptide binding]; other site 866345000727 flagellar assembly protein FliW; Provisional; Region: PRK13283 866345000728 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 866345000729 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866345000730 active site 866345000731 HIGH motif; other site 866345000732 nucleotide binding site [chemical binding]; other site 866345000733 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 866345000734 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 866345000735 active site 866345000736 KMSKS motif; other site 866345000737 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 866345000738 anticodon binding site; other site 866345000739 signal recognition particle protein; Provisional; Region: PRK10867 866345000740 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 866345000741 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 866345000742 P loop; other site 866345000743 GTP binding site [chemical binding]; other site 866345000744 Signal peptide binding domain; Region: SRP_SPB; pfam02978 866345000745 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 866345000746 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 866345000747 KH domain; Region: KH_4; pfam13083 866345000748 G-X-X-G motif; other site 866345000749 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 866345000750 RimM N-terminal domain; Region: RimM; pfam01782 866345000751 PRC-barrel domain; Region: PRC; pfam05239 866345000752 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 866345000753 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 866345000754 LabA_like proteins; Region: LabA_like; cd06167 866345000755 Uncharacterized conserved protein [Function unknown]; Region: COG1432 866345000756 putative metal binding site [ion binding]; other site 866345000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 866345000758 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 866345000759 PHP-associated; Region: PHP_C; pfam13263 866345000760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345000761 Walker A/P-loop; other site 866345000762 ATP binding site [chemical binding]; other site 866345000763 Q-loop/lid; other site 866345000764 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 866345000765 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 866345000766 putative active site [active] 866345000767 substrate binding site [chemical binding]; other site 866345000768 putative cosubstrate binding site; other site 866345000769 catalytic site [active] 866345000770 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 866345000771 substrate binding site [chemical binding]; other site 866345000772 biotin--protein ligase; Provisional; Region: PRK08477 866345000773 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 866345000774 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 866345000775 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 866345000776 P-loop; other site 866345000777 Magnesium ion binding site [ion binding]; other site 866345000778 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 866345000779 ParB-like nuclease domain; Region: ParB; smart00470 866345000780 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 866345000781 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 866345000782 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 866345000783 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13431 866345000784 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 866345000785 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 866345000786 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 866345000787 beta subunit interaction interface [polypeptide binding]; other site 866345000788 Walker A motif; other site 866345000789 ATP binding site [chemical binding]; other site 866345000790 Walker B motif; other site 866345000791 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 866345000792 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 866345000793 core domain interface [polypeptide binding]; other site 866345000794 delta subunit interface [polypeptide binding]; other site 866345000795 epsilon subunit interface [polypeptide binding]; other site 866345000796 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 866345000797 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 866345000798 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 866345000799 alpha subunit interaction interface [polypeptide binding]; other site 866345000800 Walker A motif; other site 866345000801 ATP binding site [chemical binding]; other site 866345000802 Walker B motif; other site 866345000803 inhibitor binding site; inhibition site 866345000804 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 866345000805 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 866345000806 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 866345000807 gamma subunit interface [polypeptide binding]; other site 866345000808 epsilon subunit interface [polypeptide binding]; other site 866345000809 LBP interface [polypeptide binding]; other site 866345000810 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 866345000811 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 866345000812 TolR protein; Region: tolR; TIGR02801 866345000813 TonB C terminal; Region: TonB_2; pfam13103 866345000814 translocation protein TolB; Provisional; Region: tolB; PRK04043 866345000815 TolB amino-terminal domain; Region: TolB_N; pfam04052 866345000816 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866345000817 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866345000818 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866345000819 ligand binding site [chemical binding]; other site 866345000820 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 866345000821 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 866345000822 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866345000823 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 866345000824 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345000825 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 866345000826 cofactor binding site; other site 866345000827 DNA binding site [nucleotide binding] 866345000828 substrate interaction site [chemical binding]; other site 866345000829 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 866345000830 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 866345000831 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 866345000832 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 866345000833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866345000834 binding surface 866345000835 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345000836 TPR motif; other site 866345000837 Sel1-like repeats; Region: SEL1; smart00671 866345000838 Sel1-like repeats; Region: SEL1; smart00671 866345000839 Sel1 repeat; Region: Sel1; cl02723 866345000840 excinuclease ABC subunit B; Provisional; Region: PRK05298 866345000841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345000842 ATP binding site [chemical binding]; other site 866345000843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866345000844 putative Mg++ binding site [ion binding]; other site 866345000845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345000846 nucleotide binding region [chemical binding]; other site 866345000847 ATP-binding site [chemical binding]; other site 866345000848 Ultra-violet resistance protein B; Region: UvrB; pfam12344 866345000849 UvrB/uvrC motif; Region: UVR; pfam02151 866345000850 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000851 adenylosuccinate lyase; Provisional; Region: PRK08470 866345000852 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 866345000853 tetramer interface [polypeptide binding]; other site 866345000854 active site 866345000855 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 866345000856 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 866345000857 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 866345000858 TPP-binding site [chemical binding]; other site 866345000859 putative dimer interface [polypeptide binding]; other site 866345000860 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 866345000861 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 866345000862 dimer interface [polypeptide binding]; other site 866345000863 PYR/PP interface [polypeptide binding]; other site 866345000864 TPP binding site [chemical binding]; other site 866345000865 substrate binding site [chemical binding]; other site 866345000866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866345000867 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 866345000868 4Fe-4S binding domain; Region: Fer4; pfam00037 866345000869 pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844 866345000870 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 866345000871 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000872 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 866345000873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866345000874 active site 866345000875 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 866345000876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866345000877 active site 866345000878 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 866345000879 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 866345000880 putative NAD(P) binding site [chemical binding]; other site 866345000881 putative substrate binding site [chemical binding]; other site 866345000882 catalytic Zn binding site [ion binding]; other site 866345000883 structural Zn binding site [ion binding]; other site 866345000884 dimer interface [polypeptide binding]; other site 866345000885 glucokinase; Provisional; Region: glk; PRK00292 866345000886 glucokinase, proteobacterial type; Region: glk; TIGR00749 866345000887 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 866345000888 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 866345000889 putative active site [active] 866345000890 Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364 866345000891 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 866345000892 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 866345000893 phosphogluconate dehydratase; Validated; Region: PRK09054 866345000894 6-phosphogluconate dehydratase; Region: edd; TIGR01196 866345000895 Entner-Doudoroff aldolase; Region: eda; TIGR01182 866345000896 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 866345000897 active site 866345000898 intersubunit interface [polypeptide binding]; other site 866345000899 catalytic residue [active] 866345000900 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345000901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866345000902 binding surface 866345000903 TPR motif; other site 866345000904 Sel1-like repeats; Region: SEL1; smart00671 866345000905 Sel1-like repeats; Region: SEL1; smart00671 866345000906 Sel1-like repeats; Region: SEL1; smart00671 866345000907 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 866345000908 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 866345000909 putative NAD(P) binding site [chemical binding]; other site 866345000910 homodimer interface [polypeptide binding]; other site 866345000911 homotetramer interface [polypeptide binding]; other site 866345000912 active site 866345000913 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 866345000914 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 866345000915 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 866345000916 NAD binding site [chemical binding]; other site 866345000917 homodimer interface [polypeptide binding]; other site 866345000918 active site 866345000919 substrate binding site [chemical binding]; other site 866345000920 tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071 866345000921 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 866345000922 dimerization interface 3.5A [polypeptide binding]; other site 866345000923 active site 866345000924 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 866345000925 Predicted permeases [General function prediction only]; Region: COG0795 866345000926 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 866345000927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345000928 S-adenosylmethionine binding site [chemical binding]; other site 866345000929 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 866345000930 dimer interface [polypeptide binding]; other site 866345000931 putative radical transfer pathway; other site 866345000932 diiron center [ion binding]; other site 866345000933 tyrosyl radical; other site 866345000934 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 866345000935 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 866345000936 inhibitor-cofactor binding pocket; inhibition site 866345000937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345000938 catalytic residue [active] 866345000939 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866345000940 biotin carboxylase; Validated; Region: PRK08462 866345000941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866345000942 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 866345000943 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 866345000944 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 866345000945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 866345000946 carboxyltransferase (CT) interaction site; other site 866345000947 biotinylation site [posttranslational modification]; other site 866345000948 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 866345000949 trimer interface [polypeptide binding]; other site 866345000950 active site 866345000951 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345000952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 866345000953 RNA methyltransferase, RsmE family; Region: TIGR00046 866345000954 ferrochelatase; Region: hemH; TIGR00109 866345000955 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 866345000956 C-terminal domain interface [polypeptide binding]; other site 866345000957 active site 866345000958 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 866345000959 active site 866345000960 N-terminal domain interface [polypeptide binding]; other site 866345000961 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 866345000962 catalytic residues [active] 866345000963 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 866345000964 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 866345000965 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 866345000966 glutamate dehydrogenase; Provisional; Region: PRK09414 866345000967 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 866345000968 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 866345000969 NAD(P) binding site [chemical binding]; other site 866345000970 HemK family putative methylases; Region: hemK_fam; TIGR00536 866345000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 866345000972 Peptidase family M48; Region: Peptidase_M48; pfam01435 866345000973 Sporulation related domain; Region: SPOR; pfam05036 866345000974 primosome assembly protein PriA; Validated; Region: PRK05580 866345000975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345000976 ATP binding site [chemical binding]; other site 866345000977 putative Mg++ binding site [ion binding]; other site 866345000978 helicase superfamily c-terminal domain; Region: HELICc; smart00490 866345000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345000980 S-adenosylmethionine binding site [chemical binding]; other site 866345000981 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 866345000982 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 866345000983 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 866345000984 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 866345000985 dimer interface [polypeptide binding]; other site 866345000986 catalytic triad [active] 866345000987 peroxidatic and resolving cysteines [active] 866345000988 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 866345000989 putative CheA interaction surface; other site 866345000990 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 866345000991 putative binding surface; other site 866345000992 active site 866345000993 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 866345000994 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 866345000995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345000996 ATP binding site [chemical binding]; other site 866345000997 Mg2+ binding site [ion binding]; other site 866345000998 G-X-G motif; other site 866345000999 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 866345001000 Response regulator receiver domain; Region: Response_reg; pfam00072 866345001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345001002 active site 866345001003 phosphorylation site [posttranslational modification] 866345001004 intermolecular recognition site; other site 866345001005 dimerization interface [polypeptide binding]; other site 866345001006 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 866345001007 putative CheA interaction surface; other site 866345001008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866345001009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345001010 active site 866345001011 phosphorylation site [posttranslational modification] 866345001012 intermolecular recognition site; other site 866345001013 dimerization interface [polypeptide binding]; other site 866345001014 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 866345001015 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866345001016 putative active site [active] 866345001017 putative metal binding site [ion binding]; other site 866345001018 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 866345001019 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866345001020 catalytic residue [active] 866345001021 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 866345001022 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 866345001023 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 866345001024 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 866345001025 ligand binding site [chemical binding]; other site 866345001026 NAD binding site [chemical binding]; other site 866345001027 dimerization interface [polypeptide binding]; other site 866345001028 catalytic site [active] 866345001029 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 866345001030 putative L-serine binding site [chemical binding]; other site 866345001031 ribosomal protein S1; Region: rpsA; TIGR00717 866345001032 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 866345001033 RNA binding site [nucleotide binding]; other site 866345001034 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 866345001035 RNA binding site [nucleotide binding]; other site 866345001036 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866345001037 RNA binding site [nucleotide binding]; other site 866345001038 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866345001039 RNA binding site [nucleotide binding]; other site 866345001040 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 866345001041 RNA binding site [nucleotide binding]; other site 866345001042 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 866345001043 LytB protein; Region: LYTB; pfam02401 866345001044 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 866345001045 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 866345001046 hinge; other site 866345001047 active site 866345001048 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 866345001049 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 866345001050 putative tRNA-binding site [nucleotide binding]; other site 866345001051 tRNA synthetase B5 domain; Region: B5; pfam03484 866345001052 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 866345001053 dimer interface [polypeptide binding]; other site 866345001054 motif 1; other site 866345001055 motif 3; other site 866345001056 motif 2; other site 866345001057 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 866345001058 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 866345001059 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 866345001060 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 866345001061 dimer interface [polypeptide binding]; other site 866345001062 motif 1; other site 866345001063 active site 866345001064 motif 2; other site 866345001065 motif 3; other site 866345001066 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 866345001067 nucleotide binding site/active site [active] 866345001068 HIT family signature motif; other site 866345001069 catalytic residue [active] 866345001070 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 866345001071 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866345001072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866345001073 catalytic residue [active] 866345001074 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 866345001075 potential frameshift: common BLAST hit: gi|188527828|ref|YP_001910515.1| biotin sulfoxide reductase BisC 866345001076 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345001077 potential frameshift: common BLAST hit: gi|308183150|ref|YP_003927277.1| biotin sulfoxide reductase (bisC) 866345001078 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345001079 molybdopterin cofactor binding site; other site 866345001080 potential frameshift: common BLAST hit: gi|308184785|ref|YP_003928918.1| Biotin sulfoxide reductase; putative signal peptide 866345001081 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345001082 potential frameshift: common BLAST hit: gi|208434943|ref|YP_002266609.1| biotin sulfoxide reductase 866345001083 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345001084 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866345001085 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 866345001086 molybdopterin cofactor binding site; other site 866345001087 GMP synthase; Reviewed; Region: guaA; PRK00074 866345001088 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 866345001089 AMP/PPi binding site [chemical binding]; other site 866345001090 candidate oxyanion hole; other site 866345001091 catalytic triad [active] 866345001092 potential glutamine specificity residues [chemical binding]; other site 866345001093 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 866345001094 ATP Binding subdomain [chemical binding]; other site 866345001095 Ligand Binding sites [chemical binding]; other site 866345001096 Dimerization subdomain; other site 866345001097 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 866345001098 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866345001099 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866345001100 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 866345001101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345001102 S-adenosylmethionine binding site [chemical binding]; other site 866345001103 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 866345001104 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 866345001105 active site 866345001106 HIGH motif; other site 866345001107 KMSKS motif; other site 866345001108 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 866345001109 anticodon binding site; other site 866345001110 tRNA binding surface [nucleotide binding]; other site 866345001111 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 866345001112 dimer interface [polypeptide binding]; other site 866345001113 putative tRNA-binding site [nucleotide binding]; other site 866345001114 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 866345001115 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866345001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345001117 S-adenosylmethionine binding site [chemical binding]; other site 866345001118 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 866345001119 active site 2 [active] 866345001120 active site 1 [active] 866345001121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866345001122 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 866345001123 putative ADP-binding pocket [chemical binding]; other site 866345001124 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 866345001125 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 866345001126 active site 866345001127 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866345001128 catalytic residues [active] 866345001129 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 866345001130 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345001131 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345001132 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345001133 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345001134 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866345001135 cell division protein FtsZ; Validated; Region: PRK09330 866345001136 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 866345001137 nucleotide binding site [chemical binding]; other site 866345001138 SulA interaction site; other site 866345001139 cell division protein FtsA; Region: ftsA; TIGR01174 866345001140 Cell division protein FtsA; Region: FtsA; smart00842 866345001141 Cell division protein FtsA; Region: FtsA; pfam14450 866345001142 SurA N-terminal domain; Region: SurA_N_3; cl07813 866345001143 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 866345001144 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 866345001145 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 866345001146 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866345001147 inhibitor-cofactor binding pocket; inhibition site 866345001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345001149 catalytic residue [active] 866345001150 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 866345001151 phosphoglyceromutase; Provisional; Region: PRK05434 866345001152 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 866345001153 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 866345001154 Outer membrane efflux protein; Region: OEP; pfam02321 866345001155 Outer membrane efflux protein; Region: OEP; pfam02321 866345001156 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 866345001157 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 866345001158 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 866345001159 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 866345001160 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001161 G1 box; other site 866345001162 GTP/Mg2+ binding site [chemical binding]; other site 866345001163 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001164 G3 box; other site 866345001165 Switch II region; other site 866345001166 G4 box; other site 866345001167 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001168 G1 box; other site 866345001169 GTP/Mg2+ binding site [chemical binding]; other site 866345001170 G2 box; other site 866345001171 Switch I region; other site 866345001172 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001173 G3 box; other site 866345001174 Switch II region; other site 866345001175 G4 box; other site 866345001176 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001177 Dynamin family; Region: Dynamin_N; pfam00350 866345001178 G1 box; other site 866345001179 GTP/Mg2+ binding site [chemical binding]; other site 866345001180 G2 box; other site 866345001181 Switch I region; other site 866345001182 G3 box; other site 866345001183 Switch II region; other site 866345001184 G4 box; other site 866345001185 G5 box; other site 866345001186 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 866345001187 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 866345001188 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 866345001189 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 866345001190 dimer interface [polypeptide binding]; other site 866345001191 motif 1; other site 866345001192 active site 866345001193 motif 2; other site 866345001194 motif 3; other site 866345001195 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 866345001196 Uncharacterized conserved protein [Function unknown]; Region: COG0327 866345001197 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 866345001198 Putative zinc ribbon domain; Region: DUF164; pfam02591 866345001199 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 866345001200 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 866345001201 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 866345001202 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866345001203 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866345001204 active site 866345001205 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 866345001206 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 866345001207 dimer interface [polypeptide binding]; other site 866345001208 FMN binding site [chemical binding]; other site 866345001209 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 866345001210 putative recombination protein RecO; Provisional; Region: PRK13908 866345001211 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 866345001212 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 866345001213 Uncharacterized conserved protein [Function unknown]; Region: COG1576 866345001214 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 866345001215 TRL-like protein family; Region: TRL; pfam13146 866345001216 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 866345001217 homotrimer interaction site [polypeptide binding]; other site 866345001218 putative active site [active] 866345001219 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 866345001220 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 866345001221 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 866345001222 amino acid carrier protein; Region: agcS; TIGR00835 866345001223 alanine racemase; Region: alr; TIGR00492 866345001224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 866345001225 active site 866345001226 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866345001227 dimer interface [polypeptide binding]; other site 866345001228 substrate binding site [chemical binding]; other site 866345001229 catalytic residues [active] 866345001230 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 866345001231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 866345001232 substrate binding pocket [chemical binding]; other site 866345001233 membrane-bound complex binding site; other site 866345001234 hinge residues; other site 866345001235 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 866345001236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345001237 dimer interface [polypeptide binding]; other site 866345001238 conserved gate region; other site 866345001239 putative PBP binding loops; other site 866345001240 ABC-ATPase subunit interface; other site 866345001241 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345001242 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345001243 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345001244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345001245 putative substrate translocation pore; other site 866345001246 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001247 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 866345001248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866345001249 Coenzyme A binding pocket [chemical binding]; other site 866345001250 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 866345001251 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 866345001252 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 866345001253 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 866345001254 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 866345001255 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 866345001256 substrate binding pocket [chemical binding]; other site 866345001257 chain length determination region; other site 866345001258 substrate-Mg2+ binding site; other site 866345001259 catalytic residues [active] 866345001260 aspartate-rich region 1; other site 866345001261 active site lid residues [active] 866345001262 aspartate-rich region 2; other site 866345001263 GTP cyclohydrolase I; Region: folE; TIGR00063 866345001264 GTP cyclohydrolase I; Provisional; Region: PLN03044 866345001265 active site 866345001266 heat shock protein HtpX; Provisional; Region: PRK02870 866345001267 tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094 866345001268 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 866345001269 Permutation of conserved domain; other site 866345001270 active site 866345001271 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 866345001272 recombination protein RecR; Region: recR; TIGR00615 866345001273 RecR protein; Region: RecR; pfam02132 866345001274 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 866345001275 putative active site [active] 866345001276 putative metal-binding site [ion binding]; other site 866345001277 tetramer interface [polypeptide binding]; other site 866345001278 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 866345001279 active site 1 [active] 866345001280 dimer interface [polypeptide binding]; other site 866345001281 hexamer interface [polypeptide binding]; other site 866345001282 active site 2 [active] 866345001283 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001284 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345001285 internal virion protein C; Region: PHA00431 866345001286 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345001287 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 866345001288 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345001289 Autotransporter beta-domain; Region: Autotransporter; pfam03797 866345001290 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 866345001291 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 866345001292 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 866345001293 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 866345001294 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 866345001295 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 866345001296 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866345001297 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866345001298 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 866345001299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866345001300 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866345001301 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 866345001302 IMP binding site; other site 866345001303 dimer interface [polypeptide binding]; other site 866345001304 interdomain contacts; other site 866345001305 partial ornithine binding site; other site 866345001306 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 866345001307 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 866345001308 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001309 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001310 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345001311 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001312 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001313 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 866345001314 Part of AAA domain; Region: AAA_19; pfam13245 866345001315 Family description; Region: UvrD_C_2; pfam13538 866345001316 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 866345001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345001318 S-adenosylmethionine binding site [chemical binding]; other site 866345001319 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 866345001320 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 866345001321 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 866345001322 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 866345001323 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 866345001324 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 866345001325 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 866345001326 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 866345001327 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 866345001328 propionate/acetate kinase; Provisional; Region: PRK12379 866345001329 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 866345001330 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 866345001331 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 866345001332 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 866345001333 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 866345001334 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 866345001335 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 866345001337 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 866345001338 short chain dehydrogenase; Validated; Region: PRK06182 866345001339 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 866345001340 NADP binding site [chemical binding]; other site 866345001341 active site 866345001342 steroid binding site; other site 866345001343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 866345001344 ABC-ATPase subunit interface; other site 866345001345 dimer interface [polypeptide binding]; other site 866345001346 putative PBP binding regions; other site 866345001347 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 866345001348 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 866345001349 Walker A/P-loop; other site 866345001350 ATP binding site [chemical binding]; other site 866345001351 Q-loop/lid; other site 866345001352 ABC transporter signature motif; other site 866345001353 Walker B; other site 866345001354 D-loop; other site 866345001355 H-loop/switch region; other site 866345001356 Vacuolating cyotoxin; Region: VacA; pfam02691 866345001357 Autotransporter beta-domain; Region: Autotransporter; pfam03797 866345001358 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 866345001359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 866345001360 active site 866345001361 HIGH motif; other site 866345001362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 866345001363 KMSKS motif; other site 866345001364 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 866345001365 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 866345001366 MviN-like protein; Region: MVIN; pfam03023 866345001367 Protein of unknown function (DUF342); Region: DUF342; pfam03961 866345001368 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 866345001369 RuvA N terminal domain; Region: RuvA_N; pfam01330 866345001370 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 866345001371 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 866345001372 Uncharacterized conserved protein [Function unknown]; Region: COG1432 866345001373 LabA_like proteins; Region: LabA_like; cd06167 866345001374 putative metal binding site [ion binding]; other site 866345001375 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 866345001376 active site 866345001377 putative DNA-binding cleft [nucleotide binding]; other site 866345001378 dimer interface [polypeptide binding]; other site 866345001379 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 866345001380 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001381 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001382 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 866345001383 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 866345001384 tetramer interface [polypeptide binding]; other site 866345001385 heme binding pocket [chemical binding]; other site 866345001386 NADPH binding site [chemical binding]; other site 866345001387 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 866345001388 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 866345001389 PhnA protein; Region: PhnA; pfam03831 866345001390 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 866345001391 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 866345001392 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 866345001393 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 866345001394 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 866345001395 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 866345001396 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 866345001397 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 866345001398 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 866345001399 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 866345001400 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 866345001401 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 866345001402 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 866345001403 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 866345001404 trimer interface [polypeptide binding]; other site 866345001405 active site 866345001406 PQQ-like domain; Region: PQQ_2; pfam13360 866345001407 pantothenate kinase; Reviewed; Region: PRK13333 866345001408 Uncharacterized conserved protein [Function unknown]; Region: COG2836 866345001409 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 866345001410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866345001411 active site 866345001412 motif I; other site 866345001413 motif II; other site 866345001414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866345001415 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 866345001416 NAD(P) binding site [chemical binding]; other site 866345001417 active site 866345001418 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 866345001419 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 866345001420 putative ribose interaction site [chemical binding]; other site 866345001421 putative ADP binding site [chemical binding]; other site 866345001422 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 866345001423 active site 866345001424 nucleotide binding site [chemical binding]; other site 866345001425 HIGH motif; other site 866345001426 KMSKS motif; other site 866345001427 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 866345001428 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 866345001429 dimer interface [polypeptide binding]; other site 866345001430 active site 866345001431 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 866345001432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 866345001433 active site 866345001434 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 866345001435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345001436 Walker A/P-loop; other site 866345001437 ATP binding site [chemical binding]; other site 866345001438 Q-loop/lid; other site 866345001439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866345001440 ABC transporter; Region: ABC_tran_2; pfam12848 866345001441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866345001442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958 866345001443 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 866345001444 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 866345001445 active site 866345001446 HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556 866345001447 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345001448 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 866345001449 cofactor binding site; other site 866345001450 DNA binding site [nucleotide binding] 866345001451 substrate interaction site [chemical binding]; other site 866345001452 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 866345001453 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866345001454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345001455 S-adenosylmethionine binding site [chemical binding]; other site 866345001456 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345001457 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345001458 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345001459 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 866345001460 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866345001461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345001462 ATP binding site [chemical binding]; other site 866345001463 putative Mg++ binding site [ion binding]; other site 866345001464 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 866345001465 substrate binding site [chemical binding]; other site 866345001466 multimerization interface [polypeptide binding]; other site 866345001467 ATP binding site [chemical binding]; other site 866345001468 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 866345001469 dimer interface [polypeptide binding]; other site 866345001470 substrate binding site [chemical binding]; other site 866345001471 ATP binding site [chemical binding]; other site 866345001472 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 866345001473 thiamine phosphate binding site [chemical binding]; other site 866345001474 active site 866345001475 pyrophosphate binding site [ion binding]; other site 866345001476 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 866345001477 Flavoprotein; Region: Flavoprotein; pfam02441 866345001478 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 866345001479 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 866345001480 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 866345001481 NAD(P) binding site [chemical binding]; other site 866345001482 homodimer interface [polypeptide binding]; other site 866345001483 substrate binding site [chemical binding]; other site 866345001484 active site 866345001485 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 866345001486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 866345001487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 866345001488 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 866345001489 IHF dimer interface [polypeptide binding]; other site 866345001490 IHF - DNA interface [nucleotide binding]; other site 866345001491 GTP-binding protein Der; Reviewed; Region: PRK00093 866345001492 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 866345001493 G1 box; other site 866345001494 GTP/Mg2+ binding site [chemical binding]; other site 866345001495 Switch I region; other site 866345001496 G2 box; other site 866345001497 Switch II region; other site 866345001498 G3 box; other site 866345001499 G4 box; other site 866345001500 G5 box; other site 866345001501 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 866345001502 G1 box; other site 866345001503 GTP/Mg2+ binding site [chemical binding]; other site 866345001504 Switch I region; other site 866345001505 G2 box; other site 866345001506 G3 box; other site 866345001507 Switch II region; other site 866345001508 G4 box; other site 866345001509 G5 box; other site 866345001510 spermidine synthase; Provisional; Region: speE; PRK00536 866345001511 spermidine synthase; Provisional; Region: PRK00811 866345001512 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 866345001513 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 866345001514 CoA-binding site [chemical binding]; other site 866345001515 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 866345001516 indole acetimide hydrolase; Validated; Region: PRK07488 866345001517 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 866345001518 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 866345001519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 866345001520 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 866345001521 active site 866345001522 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 866345001523 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 866345001524 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 866345001525 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 866345001526 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 866345001527 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 866345001528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866345001529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866345001530 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866345001531 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866345001532 catalytic residues [active] 866345001533 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 866345001534 homoserine dehydrogenase; Provisional; Region: PRK06349 866345001535 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 866345001536 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 866345001537 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 866345001538 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 866345001539 GIY-YIG motif/motif A; other site 866345001540 active site 866345001541 catalytic site [active] 866345001542 putative DNA binding site [nucleotide binding]; other site 866345001543 metal binding site [ion binding]; metal-binding site 866345001544 UvrB/uvrC motif; Region: UVR; pfam02151 866345001545 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 866345001546 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866345001547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345001548 Walker A/P-loop; other site 866345001549 ATP binding site [chemical binding]; other site 866345001550 Q-loop/lid; other site 866345001551 ABC transporter signature motif; other site 866345001552 Walker B; other site 866345001553 D-loop; other site 866345001554 H-loop/switch region; other site 866345001555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345001556 dimer interface [polypeptide binding]; other site 866345001557 conserved gate region; other site 866345001558 ABC-ATPase subunit interface; other site 866345001559 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 866345001560 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 866345001561 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866345001562 ligand binding site [chemical binding]; other site 866345001563 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 866345001564 flagellar motor protein MotA; Validated; Region: PRK08456 866345001565 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 866345001566 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 866345001567 ATP binding site [chemical binding]; other site 866345001568 substrate interface [chemical binding]; other site 866345001569 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866345001570 Uncharacterized conserved protein [Function unknown]; Region: COG1565 866345001571 RNA methyltransferase, RsmD family; Region: TIGR00095 866345001572 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 866345001573 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 866345001574 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 866345001575 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 866345001576 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866345001577 N-terminal plug; other site 866345001578 ligand-binding site [chemical binding]; other site 866345001579 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 866345001580 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 866345001581 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 866345001582 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: ribB; TIGR00506 866345001583 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 866345001584 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 866345001585 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 866345001586 dimerization interface [polypeptide binding]; other site 866345001587 active site 866345001588 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 866345001589 MoaE interaction surface [polypeptide binding]; other site 866345001590 MoeB interaction surface [polypeptide binding]; other site 866345001591 thiocarboxylated glycine; other site 866345001592 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 866345001593 MoaE homodimer interface [polypeptide binding]; other site 866345001594 MoaD interaction [polypeptide binding]; other site 866345001595 active site residues [active] 866345001596 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 866345001597 MPT binding site; other site 866345001598 trimer interface [polypeptide binding]; other site 866345001599 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 866345001600 trimer interface [polypeptide binding]; other site 866345001601 dimer interface [polypeptide binding]; other site 866345001602 putative active site [active] 866345001603 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 866345001604 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001605 trigger factor; Provisional; Region: tig; PRK01490 866345001606 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866345001607 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 866345001608 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 866345001609 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 866345001610 oligomer interface [polypeptide binding]; other site 866345001611 active site residues [active] 866345001612 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 866345001613 active site 866345001614 catalytic residues [active] 866345001615 metal binding site [ion binding]; metal-binding site 866345001616 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 866345001617 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 866345001618 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 866345001619 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 866345001620 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 866345001621 metal-binding site [ion binding] 866345001622 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 866345001623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866345001624 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866345001625 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345001626 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345001627 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345001628 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345001629 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345001630 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 866345001631 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866345001632 FtsX-like permease family; Region: FtsX; pfam02687 866345001633 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 866345001634 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 866345001635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345001636 nucleotide binding region [chemical binding]; other site 866345001637 ATP-binding site [chemical binding]; other site 866345001638 SEC-C motif; Region: SEC-C; pfam02810 866345001639 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 866345001640 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 866345001641 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345001642 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 866345001643 aconitate hydratase 2; Region: acnB; TIGR00117 866345001644 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 866345001645 substrate binding site [chemical binding]; other site 866345001646 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 866345001647 substrate binding site [chemical binding]; other site 866345001648 ligand binding site [chemical binding]; other site 866345001649 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 866345001650 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 866345001651 putative nucleotide binding site [chemical binding]; other site 866345001652 uridine monophosphate binding site [chemical binding]; other site 866345001653 homohexameric interface [polypeptide binding]; other site 866345001654 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 866345001655 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 866345001656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866345001657 Zn2+ binding site [ion binding]; other site 866345001658 Mg2+ binding site [ion binding]; other site 866345001659 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 866345001660 synthetase active site [active] 866345001661 NTP binding site [chemical binding]; other site 866345001662 metal binding site [ion binding]; metal-binding site 866345001663 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 866345001664 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 866345001665 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 866345001666 active site 866345001667 HIGH motif; other site 866345001668 dimer interface [polypeptide binding]; other site 866345001669 KMSKS motif; other site 866345001670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866345001671 RNA binding surface [nucleotide binding]; other site 866345001672 Nitronate monooxygenase; Region: NMO; pfam03060 866345001673 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 866345001674 FMN binding site [chemical binding]; other site 866345001675 substrate binding site [chemical binding]; other site 866345001676 putative catalytic residue [active] 866345001677 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 866345001678 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 866345001679 active site 866345001680 metal binding site [ion binding]; metal-binding site 866345001681 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 866345001682 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 866345001683 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 866345001684 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 866345001685 GTP binding site; other site 866345001686 potential frameshift: common BLAST hit: gi|383749566|ref|YP_005424669.1| molybdenum cofactor biosynthesis protein A 866345001687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 866345001688 FeS/SAM binding site; other site 866345001689 potential frameshift: common BLAST hit: gi|15645387|ref|NP_207561.1| molybdenum cofactor biosynthesis protein A 866345001690 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 866345001691 potential frameshift: common BLAST hit: gi|188527386|ref|YP_001910073.1| molybdenum cofactor biosynthesis protein A 866345001692 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 866345001693 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 866345001694 Mu-like prophage protein [General function prediction only]; Region: COG3941 866345001695 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 866345001696 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 866345001697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 866345001698 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 866345001699 phosphodiesterase; Provisional; Region: PRK12704 866345001700 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 866345001701 nucleic acid binding region [nucleotide binding]; other site 866345001702 G-X-X-G motif; other site 866345001703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866345001704 Zn2+ binding site [ion binding]; other site 866345001705 Mg2+ binding site [ion binding]; other site 866345001706 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 866345001707 putative efflux protein, MATE family; Region: matE; TIGR00797 866345001708 Predicted permease [General function prediction only]; Region: COG2056 866345001709 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 866345001710 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 866345001711 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 866345001712 putative active site; other site 866345001713 catalytic triad [active] 866345001714 putative dimer interface [polypeptide binding]; other site 866345001715 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 866345001716 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 866345001717 putative ATP binding site [chemical binding]; other site 866345001718 putative substrate interface [chemical binding]; other site 866345001719 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 866345001720 flagellar capping protein; Validated; Region: fliD; PRK08453 866345001721 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 866345001722 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 866345001723 flagellar protein FlaG; Provisional; Region: PRK08452 866345001724 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866345001725 Peptidase family M23; Region: Peptidase_M23; pfam01551 866345001726 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 866345001727 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866345001728 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866345001729 Walker A/P-loop; other site 866345001730 ATP binding site [chemical binding]; other site 866345001731 Q-loop/lid; other site 866345001732 ABC transporter signature motif; other site 866345001733 Walker B; other site 866345001734 D-loop; other site 866345001735 H-loop/switch region; other site 866345001736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345001737 S-adenosylmethionine binding site [chemical binding]; other site 866345001738 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 866345001739 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 866345001740 Interdomain contacts; other site 866345001741 Cytokine receptor motif; other site 866345001742 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 866345001743 Interdomain contacts; other site 866345001744 Cytokine receptor motif; other site 866345001745 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 866345001746 Interdomain contacts; other site 866345001747 Cytokine receptor motif; other site 866345001748 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866345001749 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866345001750 active site 866345001751 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 866345001752 G1 box; other site 866345001753 GTP/Mg2+ binding site [chemical binding]; other site 866345001754 G2 box; other site 866345001755 Switch I region; other site 866345001756 G3 box; other site 866345001757 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 866345001758 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 866345001759 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 866345001760 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 866345001761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866345001762 active site 866345001763 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 866345001764 nucleotide binding site/active site [active] 866345001765 HIT family signature motif; other site 866345001766 catalytic residue [active] 866345001767 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 866345001768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866345001769 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866345001770 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 866345001771 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 866345001772 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866345001773 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 866345001774 tetramer interfaces [polypeptide binding]; other site 866345001775 binuclear metal-binding site [ion binding]; other site 866345001776 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 866345001777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866345001778 catalytic residue [active] 866345001779 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 866345001780 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866345001781 active site 866345001782 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 866345001783 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866345001784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345001785 FeS/SAM binding site; other site 866345001786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345001787 Walker A/P-loop; other site 866345001788 ATP binding site [chemical binding]; other site 866345001789 potential frameshift: common BLAST hit: gi|254779290|ref|YP_003057395.1| LeoA protein 866345001790 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 866345001791 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 866345001792 Ligand Binding Site [chemical binding]; other site 866345001793 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 866345001794 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 866345001795 FMN binding site [chemical binding]; other site 866345001796 active site 866345001797 catalytic residues [active] 866345001798 substrate binding site [chemical binding]; other site 866345001799 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001800 anaerobic c4-dicarboxylate membrane transporter family protein; Region: Dcu; TIGR00770 866345001801 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 866345001802 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 866345001803 active site 866345001804 homodimer interface [polypeptide binding]; other site 866345001805 homotetramer interface [polypeptide binding]; other site 866345001806 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 866345001807 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 866345001808 Lysine efflux permease [General function prediction only]; Region: COG1279 866345001809 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 866345001810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345001811 Walker A motif; other site 866345001812 ATP binding site [chemical binding]; other site 866345001813 Walker B motif; other site 866345001814 arginine finger; other site 866345001815 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 866345001816 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 866345001817 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 866345001818 Walker A/P-loop; other site 866345001819 ATP binding site [chemical binding]; other site 866345001820 Q-loop/lid; other site 866345001821 ABC transporter signature motif; other site 866345001822 Walker B; other site 866345001823 D-loop; other site 866345001824 H-loop/switch region; other site 866345001825 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 866345001826 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 866345001827 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 866345001828 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 866345001829 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001830 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 866345001831 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 866345001832 Uncharacterized conserved protein [Function unknown]; Region: COG1912 866345001833 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 866345001834 MraW methylase family; Region: Methyltransf_5; cl17771 866345001835 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001836 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 866345001837 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866345001838 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866345001839 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 866345001840 Response regulator receiver domain; Region: Response_reg; pfam00072 866345001841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345001842 active site 866345001843 phosphorylation site [posttranslational modification] 866345001844 intermolecular recognition site; other site 866345001845 dimerization interface [polypeptide binding]; other site 866345001846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345001847 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 866345001848 Walker A motif; other site 866345001849 ATP binding site [chemical binding]; other site 866345001850 Walker B motif; other site 866345001851 arginine finger; other site 866345001852 DNA gyrase subunit A; Validated; Region: PRK05560 866345001853 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 866345001854 CAP-like domain; other site 866345001855 active site 866345001856 primary dimer interface [polypeptide binding]; other site 866345001857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866345001863 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 866345001864 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 866345001865 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 866345001866 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 866345001867 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 866345001868 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 866345001869 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 866345001870 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 866345001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 866345001872 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 866345001873 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 866345001874 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 866345001875 putative acyltransferase; Provisional; Region: PRK05790 866345001876 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 866345001877 dimer interface [polypeptide binding]; other site 866345001878 active site 866345001879 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 866345001880 active site 866345001881 catalytic site [active] 866345001882 substrate binding site [chemical binding]; other site 866345001883 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 866345001884 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 866345001885 ferrous iron transporter FeoB; Region: feoB; TIGR00437 866345001886 G1 box; other site 866345001887 GTP/Mg2+ binding site [chemical binding]; other site 866345001888 Switch I region; other site 866345001889 G2 box; other site 866345001890 G3 box; other site 866345001891 Switch II region; other site 866345001892 G4 box; other site 866345001893 G5 box; other site 866345001894 Nucleoside recognition; Region: Gate; pfam07670 866345001895 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 866345001896 Nucleoside recognition; Region: Gate; pfam07670 866345001897 potential frameshift: common BLAST hit: gi|188527469|ref|YP_001910156.1| iron(III) dicitrate transport protein 866345001898 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001899 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 866345001900 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345001901 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 866345001902 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 866345001903 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 866345001904 Substrate binding site; other site 866345001905 Mg++ binding site; other site 866345001906 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 866345001907 active site 866345001908 substrate binding site [chemical binding]; other site 866345001909 CoA binding site [chemical binding]; other site 866345001910 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 866345001911 ATP cone domain; Region: ATP-cone; pfam03477 866345001912 Class I ribonucleotide reductase; Region: RNR_I; cd01679 866345001913 active site 866345001914 dimer interface [polypeptide binding]; other site 866345001915 catalytic residues [active] 866345001916 effector binding site; other site 866345001917 R2 peptide binding site; other site 866345001918 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866345001919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866345001920 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 866345001921 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 866345001922 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 866345001923 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 866345001924 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 866345001925 DNA binding site [nucleotide binding] 866345001926 active site 866345001927 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 866345001928 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866345001929 active site 866345001930 DNA binding site [nucleotide binding] 866345001931 Int/Topo IB signature motif; other site 866345001932 aspartate aminotransferase; Provisional; Region: PRK05764 866345001933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866345001934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345001935 homodimer interface [polypeptide binding]; other site 866345001936 catalytic residue [active] 866345001937 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345001938 Predicted helicase [General function prediction only]; Region: COG4889 866345001939 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 866345001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345001941 ATP binding site [chemical binding]; other site 866345001942 putative Mg++ binding site [ion binding]; other site 866345001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345001944 nucleotide binding region [chemical binding]; other site 866345001945 ATP-binding site [chemical binding]; other site 866345001946 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 866345001947 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 866345001948 Cysteine-rich domain; Region: CCG; pfam02754 866345001949 Cysteine-rich domain; Region: CCG; pfam02754 866345001950 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 866345001951 HemN C-terminal domain; Region: HemN_C; pfam06969 866345001952 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 866345001953 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 866345001954 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 866345001955 Tetramer interface [polypeptide binding]; other site 866345001956 active site 866345001957 FMN-binding site [chemical binding]; other site 866345001958 ribonuclease III; Reviewed; Region: rnc; PRK00102 866345001959 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 866345001960 dimerization interface [polypeptide binding]; other site 866345001961 active site 866345001962 metal binding site [ion binding]; metal-binding site 866345001963 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 866345001964 dsRNA binding site [nucleotide binding]; other site 866345001965 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 866345001966 RNA/DNA hybrid binding site [nucleotide binding]; other site 866345001967 active site 866345001968 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 866345001969 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 866345001970 SurA N-terminal domain; Region: SurA_N; pfam09312 866345001971 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 866345001972 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 866345001973 GatB domain; Region: GatB_Yqey; smart00845 866345001974 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866345001975 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866345001976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866345001977 hypothetical protein; Provisional; Region: PRK08445 866345001978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345001979 FeS/SAM binding site; other site 866345001980 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 866345001981 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866345001982 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866345001983 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866345001984 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866345001985 Surface antigen; Region: Bac_surface_Ag; pfam01103 866345001986 hypothetical protein; Provisional; Region: PRK08444 866345001987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345001988 FeS/SAM binding site; other site 866345001989 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 866345001990 Ferritin-like domain; Region: Ferritin; pfam00210 866345001991 ferroxidase diiron center [ion binding]; other site 866345001992 phosphoserine phosphatase SerB; Region: serB; TIGR00338 866345001993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866345001994 motif II; other site 866345001995 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 866345001996 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 866345001997 ligand binding site [chemical binding]; other site 866345001998 active site 866345001999 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 866345002000 Aspartase; Region: Aspartase; cd01357 866345002001 active sites [active] 866345002002 tetramer interface [polypeptide binding]; other site 866345002003 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 866345002004 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 866345002005 hinge; other site 866345002006 active site 866345002007 sensor protein RstB; Provisional; Region: PRK10604 866345002008 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 866345002009 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 866345002010 active site 866345002011 tetramer interface; other site 866345002012 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 866345002013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866345002014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866345002015 catalytic residue [active] 866345002016 YGGT family; Region: YGGT; pfam02325 866345002017 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 866345002018 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866345002019 active site 866345002020 HIGH motif; other site 866345002021 nucleotide binding site [chemical binding]; other site 866345002022 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 866345002023 active site 866345002024 KMSKS motif; other site 866345002025 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 866345002026 dimer interface [polypeptide binding]; other site 866345002027 FMN binding site [chemical binding]; other site 866345002028 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 866345002029 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 866345002030 active site 866345002031 NTP binding site [chemical binding]; other site 866345002032 metal binding triad [ion binding]; metal-binding site 866345002033 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 866345002034 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 866345002035 Ligand Binding Site [chemical binding]; other site 866345002036 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002037 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 866345002038 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 866345002039 nickel binding site [ion binding]; other site 866345002040 putative substrate-binding site; other site 866345002041 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 866345002042 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 866345002043 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 866345002044 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 866345002045 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 866345002046 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 866345002047 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345002048 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345002049 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345002050 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345002051 Sel1-like repeats; Region: SEL1; smart00671 866345002052 Sel1-like repeats; Region: SEL1; smart00671 866345002053 Sel1 repeat; Region: Sel1; cl02723 866345002054 Sel1-like repeats; Region: SEL1; smart00671 866345002055 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 866345002056 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 866345002057 putative trimer interface [polypeptide binding]; other site 866345002058 putative CoA binding site [chemical binding]; other site 866345002059 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 866345002060 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 866345002061 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 866345002062 hypothetical protein; Provisional; Region: PRK05839 866345002063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866345002064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345002065 homodimer interface [polypeptide binding]; other site 866345002066 catalytic residue [active] 866345002067 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 866345002068 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866345002069 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866345002070 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866345002071 MutS2 family protein; Region: mutS2; TIGR01069 866345002072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002073 Walker A/P-loop; other site 866345002074 ATP binding site [chemical binding]; other site 866345002075 Q-loop/lid; other site 866345002076 ABC transporter signature motif; other site 866345002077 Walker B; other site 866345002078 D-loop; other site 866345002079 H-loop/switch region; other site 866345002080 Smr domain; Region: Smr; pfam01713 866345002081 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 866345002082 dimer interface [polypeptide binding]; other site 866345002083 substrate binding site [chemical binding]; other site 866345002084 metal binding sites [ion binding]; metal-binding site 866345002085 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 866345002086 Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306 866345002087 potential protein location (hypothetical protein) that overlaps protein (putative lipopolysaccharide biosynthesis protein) 866345002088 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 866345002089 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 866345002090 adenylate kinase; Reviewed; Region: adk; PRK00279 866345002091 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 866345002092 AMP-binding site [chemical binding]; other site 866345002093 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 866345002094 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 866345002095 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 866345002096 dimer interface [polypeptide binding]; other site 866345002097 anticodon binding site; other site 866345002098 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 866345002099 homodimer interface [polypeptide binding]; other site 866345002100 motif 1; other site 866345002101 active site 866345002102 motif 2; other site 866345002103 GAD domain; Region: GAD; pfam02938 866345002104 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 866345002105 active site 866345002106 motif 3; other site 866345002107 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 866345002108 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866345002109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345002110 active site 866345002111 phosphorylation site [posttranslational modification] 866345002112 intermolecular recognition site; other site 866345002113 dimerization interface [polypeptide binding]; other site 866345002114 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 866345002115 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 866345002116 nucleotide binding pocket [chemical binding]; other site 866345002117 K-X-D-G motif; other site 866345002118 catalytic site [active] 866345002119 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 866345002120 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 866345002121 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 866345002122 Dimer interface [polypeptide binding]; other site 866345002123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866345002124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002125 Walker A/P-loop; other site 866345002126 ATP binding site [chemical binding]; other site 866345002127 Q-loop/lid; other site 866345002128 ABC transporter signature motif; other site 866345002129 Walker B; other site 866345002130 D-loop; other site 866345002131 H-loop/switch region; other site 866345002132 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 866345002133 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345002134 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345002135 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345002136 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345002137 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 866345002138 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 866345002139 Autotransporter beta-domain; Region: Autotransporter; pfam03797 866345002140 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002141 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 866345002142 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866345002143 HlyD family secretion protein; Region: HlyD_3; pfam13437 866345002144 Outer membrane efflux protein; Region: OEP; pfam02321 866345002145 Outer membrane efflux protein; Region: OEP; pfam02321 866345002146 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 866345002147 substrate binding site [chemical binding]; other site 866345002148 active site 866345002149 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 866345002150 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 866345002151 minor groove reading motif; other site 866345002152 helix-hairpin-helix signature motif; other site 866345002153 active site 866345002154 flagellin A; Reviewed; Region: PRK12584 866345002155 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 866345002156 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 866345002157 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 866345002158 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 866345002159 potential frameshift: common BLAST hit: gi|308182762|ref|YP_003926889.1| ABC-type transport system, permease and ATP-binding protein 866345002160 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866345002161 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 866345002162 Walker A/P-loop; other site 866345002163 ATP binding site [chemical binding]; other site 866345002164 Q-loop/lid; other site 866345002165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866345002166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002167 ABC transporter signature motif; other site 866345002168 Walker B; other site 866345002169 D-loop; other site 866345002170 H-loop/switch region; other site 866345002171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 866345002172 dimer interface [polypeptide binding]; other site 866345002173 putative CheW interface [polypeptide binding]; other site 866345002174 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 866345002175 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 866345002176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866345002177 catalytic residue [active] 866345002178 Transglycosylase; Region: Transgly; pfam00912 866345002179 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 866345002180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 866345002181 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 866345002182 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 866345002183 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 866345002184 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 866345002185 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 866345002186 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 866345002187 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 866345002188 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 866345002189 TPP-binding site [chemical binding]; other site 866345002190 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 866345002191 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 866345002192 dimer interface [polypeptide binding]; other site 866345002193 PYR/PP interface [polypeptide binding]; other site 866345002194 TPP binding site [chemical binding]; other site 866345002195 substrate binding site [chemical binding]; other site 866345002196 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 866345002197 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 866345002198 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 866345002199 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 866345002200 dimerization interface [polypeptide binding]; other site 866345002201 Protein of unknown function; Region: DUF3971; pfam13116 866345002202 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 866345002203 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 866345002204 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 866345002205 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 866345002206 minor groove reading motif; other site 866345002207 helix-hairpin-helix signature motif; other site 866345002208 substrate binding pocket [chemical binding]; other site 866345002209 active site 866345002210 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 866345002211 flagellar motor switch protein; Validated; Region: PRK08433 866345002212 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 866345002213 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 866345002214 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 866345002215 active site 866345002216 substrate binding pocket [chemical binding]; other site 866345002217 dimer interface [polypeptide binding]; other site 866345002218 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 866345002219 BNR repeat-like domain; Region: BNR_2; pfam13088 866345002220 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 866345002221 Sulfatase; Region: Sulfatase; pfam00884 866345002222 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 866345002223 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 866345002224 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 866345002225 homodimer interface [polypeptide binding]; other site 866345002226 NADP binding site [chemical binding]; other site 866345002227 substrate binding site [chemical binding]; other site 866345002228 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 866345002229 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 866345002230 Catalytic site [active] 866345002231 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 866345002232 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 866345002233 Peptidase family M50; Region: Peptidase_M50; pfam02163 866345002234 active site 866345002235 putative substrate binding region [chemical binding]; other site 866345002236 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 866345002237 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 866345002238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866345002239 active site 866345002240 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 866345002241 multifunctional aminopeptidase A; Provisional; Region: PRK00913 866345002242 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 866345002243 interface (dimer of trimers) [polypeptide binding]; other site 866345002244 Substrate-binding/catalytic site; other site 866345002245 Zn-binding sites [ion binding]; other site 866345002246 GTP-binding protein YchF; Reviewed; Region: PRK09601 866345002247 YchF GTPase; Region: YchF; cd01900 866345002248 G1 box; other site 866345002249 GTP/Mg2+ binding site [chemical binding]; other site 866345002250 Switch I region; other site 866345002251 G2 box; other site 866345002252 Switch II region; other site 866345002253 G3 box; other site 866345002254 G4 box; other site 866345002255 G5 box; other site 866345002256 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 866345002257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345002258 FeS/SAM binding site; other site 866345002259 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 866345002260 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 866345002261 Domain of unknown function DUF20; Region: UPF0118; pfam01594 866345002262 diaminopimelate epimerase; Region: DapF; TIGR00652 866345002263 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 866345002264 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 866345002265 Predicted membrane protein [Function unknown]; Region: COG3059 866345002266 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 866345002267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 866345002268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866345002269 NAD(P) binding site [chemical binding]; other site 866345002270 active site 866345002271 acyl carrier protein; Provisional; Region: acpP; PRK00982 866345002272 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 866345002273 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 866345002274 dimer interface [polypeptide binding]; other site 866345002275 active site 866345002276 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Region: accA; TIGR00513 866345002277 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 866345002278 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 866345002279 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 866345002280 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 866345002281 Predicted methyltransferases [General function prediction only]; Region: COG0313 866345002282 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 866345002283 putative SAM binding site [chemical binding]; other site 866345002284 putative homodimer interface [polypeptide binding]; other site 866345002285 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 866345002286 transcription termination factor Rho; Provisional; Region: rho; PRK09376 866345002287 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 866345002288 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 866345002289 RNA binding site [nucleotide binding]; other site 866345002290 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 866345002291 multimer interface [polypeptide binding]; other site 866345002292 Walker A motif; other site 866345002293 ATP binding site [chemical binding]; other site 866345002294 Walker B motif; other site 866345002295 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 866345002296 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 866345002297 CagA exotoxin; Region: CagA; pfam03507 866345002298 CagA exotoxin; Region: CagA; pfam03507 866345002299 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 866345002300 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 866345002301 prolyl-tRNA synthetase; Provisional; Region: PRK08661 866345002302 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 866345002303 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 866345002304 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 866345002305 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 866345002306 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 866345002307 VirB7 interaction site; other site 866345002308 DC-EC Repeat; Region: CagY_M; pfam07337 866345002309 DC-EC Repeat; Region: CagY_M; pfam07337 866345002310 DC-EC Repeat; Region: CagY_M; pfam07337 866345002311 DC-EC Repeat; Region: CagY_M; pfam07337 866345002312 DC-EC Repeat; Region: CagY_M; pfam07337 866345002313 DC-EC Repeat; Region: CagY_M; pfam07337 866345002314 DC-EC Repeat; Region: CagY_M; pfam07337 866345002315 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 866345002316 CagZ; Region: CagZ; pfam09053 866345002317 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 866345002318 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 866345002319 ATP binding site [chemical binding]; other site 866345002320 Walker A motif; other site 866345002321 hexamer interface [polypeptide binding]; other site 866345002322 Walker B motif; other site 866345002323 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 866345002324 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 866345002325 Walker A motif; other site 866345002326 ATP binding site [chemical binding]; other site 866345002327 Walker B motif; other site 866345002328 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345002329 Sel1 repeat; Region: Sel1; cl02723 866345002330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 866345002331 GTPase [General function prediction only]; Region: Era; COG1159 866345002332 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 866345002333 G1 box; other site 866345002334 GTP/Mg2+ binding site [chemical binding]; other site 866345002335 Switch I region; other site 866345002336 G2 box; other site 866345002337 Switch II region; other site 866345002338 G3 box; other site 866345002339 G4 box; other site 866345002340 G5 box; other site 866345002341 KH domain; Region: KH_2; pfam07650 866345002342 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 866345002343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002344 Walker A motif; other site 866345002345 ATP binding site [chemical binding]; other site 866345002346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002347 Walker B motif; other site 866345002348 arginine finger; other site 866345002349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 866345002350 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 866345002351 active site 866345002352 HslU subunit interaction site [polypeptide binding]; other site 866345002353 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 866345002354 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 866345002355 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 866345002356 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345002357 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345002358 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345002359 Uncharacterized conserved protein [Function unknown]; Region: COG3586 866345002360 glutamine synthetase, type I; Region: GlnA; TIGR00653 866345002361 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 866345002362 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 866345002363 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 866345002364 dihydrodipicolinate reductase; Region: dapB; TIGR00036 866345002365 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 866345002366 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 866345002367 FAD binding domain; Region: FAD_binding_4; pfam01565 866345002368 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 866345002369 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 866345002370 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 866345002371 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 866345002372 dimer interface [polypeptide binding]; other site 866345002373 ADP-ribose binding site [chemical binding]; other site 866345002374 active site 866345002375 nudix motif; other site 866345002376 metal binding site [ion binding]; metal-binding site 866345002377 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866345002378 Peptidase family M23; Region: Peptidase_M23; pfam01551 866345002379 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 866345002380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345002381 Mg2+ binding site [ion binding]; other site 866345002382 G-X-G motif; other site 866345002383 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 866345002384 anchoring element; other site 866345002385 dimer interface [polypeptide binding]; other site 866345002386 ATP binding site [chemical binding]; other site 866345002387 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 866345002388 active site 866345002389 putative metal-binding site [ion binding]; other site 866345002390 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 866345002391 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 866345002392 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 866345002393 putative DNA binding surface [nucleotide binding]; other site 866345002394 dimer interface [polypeptide binding]; other site 866345002395 beta-clamp/translesion DNA polymerase binding surface; other site 866345002396 beta-clamp/clamp loader binding surface; other site 866345002397 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 866345002398 dimerization interface [polypeptide binding]; other site 866345002399 substrate binding site [chemical binding]; other site 866345002400 active site 866345002401 calcium binding site [ion binding]; other site 866345002402 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 866345002403 Na2 binding site [ion binding]; other site 866345002404 putative substrate binding site 1 [chemical binding]; other site 866345002405 Na binding site 1 [ion binding]; other site 866345002406 putative substrate binding site 2 [chemical binding]; other site 866345002407 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 866345002408 Na2 binding site [ion binding]; other site 866345002409 putative substrate binding site 1 [chemical binding]; other site 866345002410 Na binding site 1 [ion binding]; other site 866345002411 putative substrate binding site 2 [chemical binding]; other site 866345002412 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 866345002413 active site 866345002414 Protein of unknown function (DUF493); Region: DUF493; pfam04359 866345002415 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 866345002416 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866345002417 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866345002418 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 866345002419 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 866345002420 Mg++ binding site [ion binding]; other site 866345002421 putative catalytic motif [active] 866345002422 putative substrate binding site [chemical binding]; other site 866345002423 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 866345002424 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 866345002425 Cation transport protein; Region: TrkH; cl17365 866345002426 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 866345002427 TrkA-N domain; Region: TrkA_N; pfam02254 866345002428 TrkA-C domain; Region: TrkA_C; pfam02080 866345002429 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 866345002430 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 866345002431 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345002432 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345002433 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 866345002434 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 866345002435 putative heme binding pocket [chemical binding]; other site 866345002436 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 866345002437 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345002438 cofactor binding site; other site 866345002439 DNA binding site [nucleotide binding] 866345002440 substrate interaction site [chemical binding]; other site 866345002441 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345002442 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 866345002443 GIY-YIG motif/motif A; other site 866345002444 DNA binding site [nucleotide binding] 866345002445 active site 866345002446 catalytic site [active] 866345002447 metal binding site [ion binding]; metal-binding site 866345002448 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 866345002449 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 866345002450 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 866345002451 G1 box; other site 866345002452 putative GEF interaction site [polypeptide binding]; other site 866345002453 GTP/Mg2+ binding site [chemical binding]; other site 866345002454 Switch I region; other site 866345002455 G2 box; other site 866345002456 G3 box; other site 866345002457 Switch II region; other site 866345002458 G4 box; other site 866345002459 G5 box; other site 866345002460 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 866345002461 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 866345002462 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 866345002463 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 866345002464 Helix-turn-helix domain; Region: HTH_17; pfam12728 866345002465 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 866345002466 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866345002467 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 866345002468 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002469 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 866345002470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866345002471 active site 866345002472 HIGH motif; other site 866345002473 nucleotide binding site [chemical binding]; other site 866345002474 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 866345002475 active site 866345002476 KMSKS motif; other site 866345002477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002478 Walker A/P-loop; other site 866345002479 ATP binding site [chemical binding]; other site 866345002480 Q-loop/lid; other site 866345002481 ABC transporter signature motif; other site 866345002482 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 866345002483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345002484 dimer interface [polypeptide binding]; other site 866345002485 conserved gate region; other site 866345002486 putative PBP binding loops; other site 866345002487 ABC-ATPase subunit interface; other site 866345002488 potential frameshift: common BLAST hit: gi|188527259|ref|YP_001909946.1| molybdenum ABC transporter ModA 866345002489 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 866345002490 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 866345002491 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002492 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 866345002493 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 866345002494 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 866345002495 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 866345002496 active site 866345002497 Zn binding site [ion binding]; other site 866345002498 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 866345002499 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 866345002500 putative metal binding site [ion binding]; other site 866345002501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 866345002502 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 866345002503 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866345002504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345002505 ATP binding site [chemical binding]; other site 866345002506 putative Mg++ binding site [ion binding]; other site 866345002507 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 866345002508 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866345002509 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345002510 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 866345002511 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 866345002512 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 866345002513 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 866345002514 putative domain interface [polypeptide binding]; other site 866345002515 putative active site [active] 866345002516 catalytic site [active] 866345002517 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 866345002518 putative active site [active] 866345002519 putative domain interface [polypeptide binding]; other site 866345002520 catalytic site [active] 866345002521 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 866345002522 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 866345002523 quinone interaction residues [chemical binding]; other site 866345002524 active site 866345002525 catalytic residues [active] 866345002526 FMN binding site [chemical binding]; other site 866345002527 substrate binding site [chemical binding]; other site 866345002528 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866345002529 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866345002530 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866345002531 dihydrodipicolinate synthase; Region: dapA; TIGR00674 866345002532 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 866345002533 dimer interface [polypeptide binding]; other site 866345002534 active site 866345002535 catalytic residue [active] 866345002536 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 866345002537 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 866345002538 putative NAD(P) binding site [chemical binding]; other site 866345002539 active site 866345002540 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 866345002541 S-methylmethionine transporter; Provisional; Region: PRK11387 866345002542 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 866345002543 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 866345002544 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 866345002545 protein binding site [polypeptide binding]; other site 866345002546 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 866345002547 protein binding site [polypeptide binding]; other site 866345002548 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 866345002549 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 866345002550 substrate binding site; other site 866345002551 dimer interface; other site 866345002552 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 866345002553 homotrimer interaction site [polypeptide binding]; other site 866345002554 zinc binding site [ion binding]; other site 866345002555 CDP-binding sites; other site 866345002556 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866345002557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345002558 active site 866345002559 dimerization interface [polypeptide binding]; other site 866345002560 5'-3' exonuclease; Provisional; Region: PRK14976 866345002561 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 866345002562 putative active site [active] 866345002563 Helix-hairpin-helix class 2 (Pol1 family) motifs; Region: HhH2; smart00279 866345002564 DNA binding site [nucleotide binding] 866345002565 metal binding site [ion binding]; metal-binding site 866345002566 chaperone protein DnaJ; Provisional; Region: PRK14299 866345002567 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 866345002568 HSP70 interaction site [polypeptide binding]; other site 866345002569 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 866345002570 substrate binding site [polypeptide binding]; other site 866345002571 dimer interface [polypeptide binding]; other site 866345002572 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 866345002573 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 866345002574 DNA binding residues [nucleotide binding] 866345002575 putative dimer interface [polypeptide binding]; other site 866345002576 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 866345002577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002578 Walker A motif; other site 866345002579 ATP binding site [chemical binding]; other site 866345002580 Walker B motif; other site 866345002581 arginine finger; other site 866345002582 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 866345002583 ferric uptake regulator; Provisional; Region: fur; PRK09462 866345002584 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 866345002585 metal binding site 2 [ion binding]; metal-binding site 866345002586 putative DNA binding helix; other site 866345002587 metal binding site 1 [ion binding]; metal-binding site 866345002588 dimer interface [polypeptide binding]; other site 866345002589 structural Zn2+ binding site [ion binding]; other site 866345002590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 866345002591 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 866345002592 flagellar motor switch protein FliY; Validated; Region: PRK08432 866345002593 flagellar motor switch protein FliN; Region: fliN; TIGR02480 866345002594 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 866345002595 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 866345002596 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 866345002597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866345002598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866345002599 DNA binding residues [nucleotide binding] 866345002600 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 866345002601 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 866345002602 P-loop; other site 866345002603 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 866345002604 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 866345002605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 866345002606 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 866345002607 catalytic center binding site [active] 866345002608 ATP binding site [chemical binding]; other site 866345002609 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 866345002610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 866345002611 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 866345002612 active site 866345002613 Dehydroquinase class II; Region: DHquinase_II; pfam01220 866345002614 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 866345002615 trimer interface [polypeptide binding]; other site 866345002616 active site 866345002617 dimer interface [polypeptide binding]; other site 866345002618 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 866345002619 O-Antigen ligase; Region: Wzy_C; pfam04932 866345002620 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 866345002621 16S/18S rRNA binding site [nucleotide binding]; other site 866345002622 S13e-L30e interaction site [polypeptide binding]; other site 866345002623 25S rRNA binding site [nucleotide binding]; other site 866345002624 flagellar biosynthesis protein FlhA; Region: FlhA; TIGR01398 866345002625 FHIPEP family; Region: FHIPEP; pfam00771 866345002626 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 866345002627 DHH family; Region: DHH; pfam01368 866345002628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866345002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345002630 active site 866345002631 intermolecular recognition site; other site 866345002632 dimerization interface [polypeptide binding]; other site 866345002633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866345002634 DNA binding site [nucleotide binding] 866345002635 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 866345002636 putative active site [active] 866345002637 putative metal binding site [ion binding]; other site 866345002638 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866345002639 acetyl-CoA synthetase; Provisional; Region: PRK00174 866345002640 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 866345002641 active site 866345002642 CoA binding site [chemical binding]; other site 866345002643 acyl-activating enzyme (AAE) consensus motif; other site 866345002644 AMP binding site [chemical binding]; other site 866345002645 acetate binding site [chemical binding]; other site 866345002646 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 866345002647 Sm and related proteins; Region: Sm_like; cl00259 866345002648 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 866345002649 putative oligomer interface [polypeptide binding]; other site 866345002650 putative RNA binding site [nucleotide binding]; other site 866345002651 Ribosome-binding factor A; Region: RBFA; cl00542 866345002652 translation initiation factor IF-2; Region: IF-2; TIGR00487 866345002653 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 866345002654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 866345002655 G1 box; other site 866345002656 putative GEF interaction site [polypeptide binding]; other site 866345002657 GTP/Mg2+ binding site [chemical binding]; other site 866345002658 Switch I region; other site 866345002659 G2 box; other site 866345002660 G3 box; other site 866345002661 Switch II region; other site 866345002662 G4 box; other site 866345002663 G5 box; other site 866345002664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 866345002665 Translation-initiation factor 2; Region: IF-2; pfam11987 866345002666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 866345002667 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 866345002668 putative RNA binding cleft [nucleotide binding]; other site 866345002669 homoserine kinase; Region: thrB; TIGR00191 866345002670 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 866345002671 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 866345002672 UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325 866345002673 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 866345002674 septum formation inhibitor; Reviewed; Region: minC; PRK00556 866345002675 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 866345002676 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866345002677 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002678 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002679 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 866345002680 oligomerization interface [polypeptide binding]; other site 866345002681 active site 866345002682 metal binding site [ion binding]; metal-binding site 866345002683 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 866345002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002685 Walker A motif; other site 866345002686 ATP binding site [chemical binding]; other site 866345002687 Walker B motif; other site 866345002688 arginine finger; other site 866345002689 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 866345002690 sec-independent translocase; Provisional; Region: PRK04098 866345002691 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 866345002692 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 866345002693 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 866345002694 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 866345002695 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 866345002696 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002697 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866345002698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345002699 active site 866345002700 phosphorylation site [posttranslational modification] 866345002701 intermolecular recognition site; other site 866345002702 dimerization interface [polypeptide binding]; other site 866345002703 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 866345002704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345002705 S-adenosylmethionine binding site [chemical binding]; other site 866345002706 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 866345002707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002708 Walker A motif; other site 866345002709 ATP binding site [chemical binding]; other site 866345002710 Walker B motif; other site 866345002711 arginine finger; other site 866345002712 Peptidase family M41; Region: Peptidase_M41; pfam01434 866345002713 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 866345002714 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 866345002715 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866345002716 metal-binding site [ion binding] 866345002717 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 866345002718 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866345002719 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866345002720 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866345002721 metal-binding site [ion binding] 866345002722 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 866345002723 active site 866345002724 Zn binding site [ion binding]; other site 866345002725 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 866345002726 Predicted ATPases [General function prediction only]; Region: COG1106 866345002727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002728 Walker A/P-loop; other site 866345002729 ATP binding site [chemical binding]; other site 866345002730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002731 Walker B; other site 866345002732 D-loop; other site 866345002733 H-loop/switch region; other site 866345002734 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787 866345002735 Restriction endonuclease; Region: Mrr_cat; pfam04471 866345002736 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 866345002737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866345002738 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866345002739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345002740 Walker A/P-loop; other site 866345002741 ATP binding site [chemical binding]; other site 866345002742 Q-loop/lid; other site 866345002743 ABC transporter signature motif; other site 866345002744 Walker B; other site 866345002745 D-loop; other site 866345002746 H-loop/switch region; other site 866345002747 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345002748 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 866345002749 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 866345002750 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 866345002751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866345002752 hemolysin TlyA family protein; Region: tly; TIGR00478 866345002753 RNA binding surface [nucleotide binding]; other site 866345002754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345002755 S-adenosylmethionine binding site [chemical binding]; other site 866345002756 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 866345002757 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 866345002758 active site 866345002759 Riboflavin kinase; Region: Flavokinase; smart00904 866345002760 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 866345002761 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 866345002762 TPP-binding site [chemical binding]; other site 866345002763 dimer interface [polypeptide binding]; other site 866345002764 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 866345002765 PYR/PP interface [polypeptide binding]; other site 866345002766 dimer interface [polypeptide binding]; other site 866345002767 TPP binding site [chemical binding]; other site 866345002768 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866345002769 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 866345002770 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 866345002771 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 866345002772 TspO/MBR family; Region: TspO_MBR; cl01379 866345002773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 866345002774 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 866345002775 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 866345002776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345002777 putative substrate translocation pore; other site 866345002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345002779 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 866345002780 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 866345002781 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 866345002782 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 866345002783 GTP-binding protein LepA; Provisional; Region: PRK05433 866345002784 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 866345002785 G1 box; other site 866345002786 putative GEF interaction site [polypeptide binding]; other site 866345002787 GTP/Mg2+ binding site [chemical binding]; other site 866345002788 Switch I region; other site 866345002789 G2 box; other site 866345002790 G3 box; other site 866345002791 Switch II region; other site 866345002792 G4 box; other site 866345002793 G5 box; other site 866345002794 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 866345002795 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 866345002796 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 866345002797 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 866345002798 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 866345002799 TPP-binding site; other site 866345002800 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 866345002801 PYR/PP interface [polypeptide binding]; other site 866345002802 dimer interface [polypeptide binding]; other site 866345002803 TPP binding site [chemical binding]; other site 866345002804 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866345002805 flagellar assembly protein H; Validated; Region: fliH; PRK06669 866345002806 Flagellar assembly protein FliH; Region: FliH; pfam02108 866345002807 flagellar motor switch protein FliG; Region: fliG; TIGR00207 866345002808 FliG C-terminal domain; Region: FliG_C; pfam01706 866345002809 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 866345002810 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 866345002811 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 866345002812 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 866345002813 active site 866345002814 CTP synthetase; Validated; Region: pyrG; PRK05380 866345002815 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 866345002816 Catalytic site [active] 866345002817 active site 866345002818 UTP binding site [chemical binding]; other site 866345002819 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 866345002820 active site 866345002821 putative oxyanion hole; other site 866345002822 catalytic triad [active] 866345002823 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 866345002824 DHH family; Region: DHH; pfam01368 866345002825 DHHA1 domain; Region: DHHA1; pfam02272 866345002826 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866345002827 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866345002828 active site 866345002829 Predicted membrane protein [Function unknown]; Region: COG3326 866345002830 catalytic residue [active] 866345002831 Phage lysozyme; Region: Phage_lysozyme; pfam00959 866345002832 chlorohydrolase; Provisional; Region: PRK07213 866345002833 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345002834 Sel1-like repeats; Region: SEL1; smart00671 866345002835 Sel1-like repeats; Region: SEL1; smart00671 866345002836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866345002837 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 866345002838 DNA protecting protein DprA; Region: dprA; TIGR00732 866345002839 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 866345002840 cell division topological specificity factor MinE; Region: minE; TIGR01215 866345002841 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 866345002842 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 866345002843 Switch I; other site 866345002844 Switch II; other site 866345002845 ketol-acid reductoisomerase; Provisional; Region: PRK05479 866345002846 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 866345002847 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 866345002848 NAD synthetase; Provisional; Region: PRK13980 866345002849 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 866345002850 homodimer interface [polypeptide binding]; other site 866345002851 NAD binding pocket [chemical binding]; other site 866345002852 ATP binding pocket [chemical binding]; other site 866345002853 Mg binding site [ion binding]; other site 866345002854 active-site loop [active] 866345002855 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 866345002856 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 866345002857 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 866345002858 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 866345002859 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 866345002860 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 866345002861 ligand binding site; other site 866345002862 tetramer interface; other site 866345002863 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 866345002864 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 866345002865 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345002866 nuclease NucT; Provisional; Region: PRK13912 866345002867 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 866345002868 putative active site [active] 866345002869 catalytic site [active] 866345002870 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 866345002871 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 866345002872 catalytic site [active] 866345002873 G-X2-G-X-G-K; other site 866345002874 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 866345002875 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 866345002876 arginyl-tRNA synthetase; Region: argS; TIGR00456 866345002877 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 866345002878 active site 866345002879 HIGH motif; other site 866345002880 KMSK motif region; other site 866345002881 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 866345002882 tRNA binding surface [nucleotide binding]; other site 866345002883 anticodon binding site; other site 866345002884 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 866345002885 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 866345002886 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 866345002887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345002888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866345002889 putative substrate translocation pore; other site 866345002890 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 866345002891 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 866345002892 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 866345002893 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 866345002894 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345002895 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 866345002896 active site 866345002897 catalytic site [active] 866345002898 Zn binding site [ion binding]; other site 866345002899 tetramer interface [polypeptide binding]; other site 866345002900 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 866345002901 Predicted amidohydrolase [General function prediction only]; Region: COG0388 866345002902 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 866345002903 active site 866345002904 catalytic triad [active] 866345002905 dimer interface [polypeptide binding]; other site 866345002906 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 866345002907 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 866345002908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866345002909 inhibitor-cofactor binding pocket; inhibition site 866345002910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345002911 catalytic residue [active] 866345002912 Alginate lyase; Region: Alginate_lyase; pfam05426 866345002913 GTPase CgtA; Reviewed; Region: obgE; PRK12299 866345002914 GTP1/OBG; Region: GTP1_OBG; pfam01018 866345002915 Obg GTPase; Region: Obg; cd01898 866345002916 G1 box; other site 866345002917 GTP/Mg2+ binding site [chemical binding]; other site 866345002918 Switch I region; other site 866345002919 G2 box; other site 866345002920 G3 box; other site 866345002921 Switch II region; other site 866345002922 G4 box; other site 866345002923 G5 box; other site 866345002924 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 866345002925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 866345002926 Walker A/P-loop; other site 866345002927 ATP binding site [chemical binding]; other site 866345002928 Q-loop/lid; other site 866345002929 ABC transporter signature motif; other site 866345002930 Walker B; other site 866345002931 D-loop; other site 866345002932 H-loop/switch region; other site 866345002933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 866345002934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 866345002935 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 866345002936 Walker A/P-loop; other site 866345002937 ATP binding site [chemical binding]; other site 866345002938 Q-loop/lid; other site 866345002939 ABC transporter signature motif; other site 866345002940 Walker B; other site 866345002941 D-loop; other site 866345002942 H-loop/switch region; other site 866345002943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 866345002944 dipeptide transporter; Provisional; Region: PRK10913 866345002945 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 866345002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345002947 dimer interface [polypeptide binding]; other site 866345002948 conserved gate region; other site 866345002949 putative PBP binding loops; other site 866345002950 ABC-ATPase subunit interface; other site 866345002951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 866345002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345002953 dimer interface [polypeptide binding]; other site 866345002954 conserved gate region; other site 866345002955 putative PBP binding loops; other site 866345002956 ABC-ATPase subunit interface; other site 866345002957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 866345002958 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 866345002959 peptide binding site [polypeptide binding]; other site 866345002960 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 866345002961 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 866345002962 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 866345002963 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 866345002964 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 866345002965 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 866345002966 multimer interface [polypeptide binding]; other site 866345002967 active site 866345002968 catalytic triad [active] 866345002969 dimer interface [polypeptide binding]; other site 866345002970 aminodeoxychorismate synthase; Provisional; Region: PRK07508 866345002971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 866345002972 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 866345002973 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 866345002974 substrate-cofactor binding pocket; other site 866345002975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345002976 catalytic residue [active] 866345002977 Uncharacterized conserved protein [Function unknown]; Region: COG4866 866345002978 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 866345002979 diaminopimelate decarboxylase; Region: lysA; TIGR01048 866345002980 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 866345002981 active site 866345002982 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866345002983 substrate binding site [chemical binding]; other site 866345002984 catalytic residues [active] 866345002985 dimer interface [polypeptide binding]; other site 866345002986 potential frameshift: common BLAST hit: gi|15611344|ref|NP_222995.1| vacuolating cytotoxin (VacA) paralog 866345002987 Autotransporter beta-domain; Region: Autotransporter; pfam03797 866345002988 Vacuolating cyotoxin; Region: VacA; pfam02691 866345002989 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 866345002990 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 866345002991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345002992 Walker A motif; other site 866345002993 ATP binding site [chemical binding]; other site 866345002994 Walker B motif; other site 866345002995 arginine finger; other site 866345002996 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 866345002997 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866345002998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345002999 FeS/SAM binding site; other site 866345003000 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866345003001 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866345003002 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 866345003003 active site 866345003004 dimer interface [polypeptide binding]; other site 866345003005 metal binding site [ion binding]; metal-binding site 866345003006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 866345003007 TrkA-C domain; Region: TrkA_C; pfam02080 866345003008 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 866345003009 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 866345003010 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 866345003011 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 866345003012 putative acyl-acceptor binding pocket; other site 866345003013 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 866345003014 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 866345003015 putative active site [active] 866345003016 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 866345003017 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 866345003018 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 866345003019 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 866345003020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 866345003021 putative acyl-acceptor binding pocket; other site 866345003022 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866345003023 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 866345003024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345003025 FeS/SAM binding site; other site 866345003026 chlorohydrolase; Provisional; Region: PRK08418 866345003027 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 866345003028 active site 866345003029 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 866345003030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866345003031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866345003032 active site 866345003033 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 866345003034 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 866345003035 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 866345003036 Clp amino terminal domain; Region: Clp_N; pfam02861 866345003037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345003038 Walker A motif; other site 866345003039 ATP binding site [chemical binding]; other site 866345003040 Walker B motif; other site 866345003041 arginine finger; other site 866345003042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345003043 Walker A motif; other site 866345003044 ATP binding site [chemical binding]; other site 866345003045 Walker B motif; other site 866345003046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 866345003047 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 866345003048 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003049 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866345003050 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003051 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003052 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 866345003053 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 866345003054 generic binding surface II; other site 866345003055 generic binding surface I; other site 866345003056 RIP metalloprotease RseP; Region: TIGR00054 866345003057 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 866345003058 active site 866345003059 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 866345003060 protein binding site [polypeptide binding]; other site 866345003061 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 866345003062 Uncharacterized conserved protein [Function unknown]; Region: COG3334 866345003063 Flagellar FliJ protein; Region: FliJ; pfam02050 866345003064 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 866345003065 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 866345003066 GDP-binding site [chemical binding]; other site 866345003067 ACT binding site; other site 866345003068 IMP binding site; other site 866345003069 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003070 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003071 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 866345003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866345003073 dimer interface [polypeptide binding]; other site 866345003074 conserved gate region; other site 866345003075 putative PBP binding loops; other site 866345003076 ABC-ATPase subunit interface; other site 866345003077 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 866345003078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 866345003079 Walker A/P-loop; other site 866345003080 ATP binding site [chemical binding]; other site 866345003081 Q-loop/lid; other site 866345003082 ABC transporter signature motif; other site 866345003083 Walker B; other site 866345003084 D-loop; other site 866345003085 H-loop/switch region; other site 866345003086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 866345003087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 866345003088 Walker A/P-loop; other site 866345003089 ATP binding site [chemical binding]; other site 866345003090 Q-loop/lid; other site 866345003091 ABC transporter signature motif; other site 866345003092 Walker B; other site 866345003093 D-loop; other site 866345003094 H-loop/switch region; other site 866345003095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 866345003096 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 866345003097 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 866345003098 SPFH domain / Band 7 family; Region: Band_7; pfam01145 866345003099 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 866345003100 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866345003101 ATP binding site [chemical binding]; other site 866345003102 Mg++ binding site [ion binding]; other site 866345003103 motif III; other site 866345003104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345003105 nucleotide binding region [chemical binding]; other site 866345003106 ATP-binding site [chemical binding]; other site 866345003107 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 866345003108 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 866345003109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866345003110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866345003111 dimer interface [polypeptide binding]; other site 866345003112 phosphorylation site [posttranslational modification] 866345003113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345003114 ATP binding site [chemical binding]; other site 866345003115 Mg2+ binding site [ion binding]; other site 866345003116 G-X-G motif; other site 866345003117 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 866345003118 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 866345003119 dimerization interface [polypeptide binding]; other site 866345003120 DPS ferroxidase diiron center [ion binding]; other site 866345003121 ion pore; other site 866345003122 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 866345003123 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 866345003124 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 866345003125 substrate binding pocket [chemical binding]; other site 866345003126 chain length determination region; other site 866345003127 substrate-Mg2+ binding site; other site 866345003128 catalytic residues [active] 866345003129 aspartate-rich region 1; other site 866345003130 active site lid residues [active] 866345003131 aspartate-rich region 2; other site 866345003132 glutamyl-tRNA reductase; Region: hemA; TIGR01035 866345003133 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 866345003134 tRNA; other site 866345003135 putative tRNA binding site [nucleotide binding]; other site 866345003136 putative NADP binding site [chemical binding]; other site 866345003137 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 866345003138 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 866345003139 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 866345003140 dimer interface [polypeptide binding]; other site 866345003141 motif 1; other site 866345003142 active site 866345003143 motif 2; other site 866345003144 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 866345003145 putative deacylase active site [active] 866345003146 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 866345003147 active site 866345003148 motif 3; other site 866345003149 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 866345003150 anticodon binding site; other site 866345003151 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 866345003152 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 866345003153 domain interfaces; other site 866345003154 active site 866345003155 Cytochrome c; Region: Cytochrom_C; cl11414 866345003156 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345003157 Sel1-like repeats; Region: SEL1; smart00671 866345003158 Sel1-like repeats; Region: SEL1; smart00671 866345003159 Sel1-like repeats; Region: SEL1; smart00671 866345003160 Sel1-like repeats; Region: SEL1; smart00671 866345003161 Sel1-like repeats; Region: SEL1; smart00671 866345003162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 866345003163 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 866345003164 hypothetical protein; Provisional; Region: PRK04081 866345003165 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 866345003166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 866345003167 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 866345003168 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 866345003169 Ligand binding site; other site 866345003170 oligomer interface; other site 866345003171 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003172 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 866345003173 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 866345003174 Sulfate transporter family; Region: Sulfate_transp; pfam00916 866345003175 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003176 Predicted permeases [General function prediction only]; Region: COG0730 866345003177 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 866345003178 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 866345003179 SelR domain; Region: SelR; pfam01641 866345003180 DNA repair protein RadA; Region: sms; TIGR00416 866345003181 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 866345003182 Walker A motif/ATP binding site; other site 866345003183 ATP binding site [chemical binding]; other site 866345003184 Walker B motif; other site 866345003185 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 866345003186 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 866345003187 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 866345003188 trimerization site [polypeptide binding]; other site 866345003189 active site 866345003190 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 866345003191 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 866345003192 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 866345003193 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 866345003194 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866345003195 catalytic residue [active] 866345003196 Helix-turn-helix domain; Region: HTH_28; pfam13518 866345003197 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 866345003198 substrate binding site [chemical binding]; other site 866345003199 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 866345003200 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 866345003201 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 866345003202 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 866345003203 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 866345003204 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 866345003205 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 866345003206 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 866345003207 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 866345003208 transmembrane helices; other site 866345003209 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 866345003210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866345003211 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 866345003212 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 866345003213 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 866345003214 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 866345003215 metal binding site [ion binding]; metal-binding site 866345003216 dimer interface [polypeptide binding]; other site 866345003217 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345003218 Sel1-like repeats; Region: SEL1; smart00671 866345003219 Sel1-like repeats; Region: SEL1; smart00671 866345003220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866345003221 TPR motif; other site 866345003222 binding surface 866345003223 heat shock protein 90; Provisional; Region: PRK05218 866345003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345003225 ATP binding site [chemical binding]; other site 866345003226 Mg2+ binding site [ion binding]; other site 866345003227 G-X-G motif; other site 866345003228 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 866345003229 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 866345003230 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 866345003231 Ligand binding site; other site 866345003232 metal-binding site 866345003233 antiporter inner membrane protein; Provisional; Region: PRK11670 866345003234 Domain of unknown function DUF59; Region: DUF59; pfam01883 866345003235 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 866345003236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345003237 Walker A/P-loop; other site 866345003238 ATP binding site [chemical binding]; other site 866345003239 AAA ATPase domain; Region: AAA_15; pfam13175 866345003240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 866345003241 Walker B; other site 866345003242 D-loop; other site 866345003243 H-loop/switch region; other site 866345003244 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 866345003245 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 866345003246 dimer interface [polypeptide binding]; other site 866345003247 active site 866345003248 CoA binding pocket [chemical binding]; other site 866345003249 fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182 866345003250 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 866345003251 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 866345003252 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 866345003253 active site 866345003254 multimer interface [polypeptide binding]; other site 866345003255 S-adenosylmethionine synthetase; Validated; Region: PRK05250 866345003256 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 866345003257 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 866345003258 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 866345003259 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 866345003260 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 866345003261 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 866345003262 trimer interface [polypeptide binding]; other site 866345003263 active site 866345003264 UDP-GlcNAc binding site [chemical binding]; other site 866345003265 lipid binding site [chemical binding]; lipid-binding site 866345003266 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 866345003267 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 866345003268 NAD binding site [chemical binding]; other site 866345003269 homotetramer interface [polypeptide binding]; other site 866345003270 homodimer interface [polypeptide binding]; other site 866345003271 substrate binding site [chemical binding]; other site 866345003272 active site 866345003273 triosephosphate isomerase; Provisional; Region: PRK14567 866345003274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 866345003275 substrate binding site [chemical binding]; other site 866345003276 dimer interface [polypeptide binding]; other site 866345003277 catalytic triad [active] 866345003278 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 866345003279 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 866345003280 Iron-sulfur protein interface; other site 866345003281 proximal heme binding site [chemical binding]; other site 866345003282 distal heme binding site [chemical binding]; other site 866345003283 dimer interface [polypeptide binding]; other site 866345003284 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 866345003285 L-aspartate oxidase; Provisional; Region: PRK06175 866345003286 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 866345003287 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 866345003288 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 866345003289 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 866345003290 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 866345003291 PLD-like domain; Region: PLDc_2; pfam13091 866345003292 putative active site [active] 866345003293 catalytic site [active] 866345003294 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 866345003295 PLD-like domain; Region: PLDc_2; pfam13091 866345003296 putative active site [active] 866345003297 catalytic site [active] 866345003298 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 866345003299 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345003300 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345003301 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 866345003302 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 866345003303 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 866345003304 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 866345003305 dimer interface [polypeptide binding]; other site 866345003306 active site 866345003307 glycine-pyridoxal phosphate binding site [chemical binding]; other site 866345003308 folate binding site [chemical binding]; other site 866345003309 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 866345003310 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 866345003311 dimer interface [polypeptide binding]; other site 866345003312 putative anticodon binding site; other site 866345003313 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 866345003314 motif 1; other site 866345003315 active site 866345003316 motif 2; other site 866345003317 motif 3; other site 866345003318 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 866345003319 Colicin V production protein; Region: Colicin_V; pfam02674 866345003320 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 866345003321 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 866345003322 active site 866345003323 catalytic triad [active] 866345003324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866345003325 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866345003326 Walker A/P-loop; other site 866345003327 ATP binding site [chemical binding]; other site 866345003328 Q-loop/lid; other site 866345003329 ABC transporter signature motif; other site 866345003330 Walker B; other site 866345003331 D-loop; other site 866345003332 H-loop/switch region; other site 866345003333 pseudaminic acid synthase; Region: PseI; TIGR03586 866345003334 NeuB family; Region: NeuB; pfam03102 866345003335 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 866345003336 NeuB binding interface [polypeptide binding]; other site 866345003337 putative substrate binding site [chemical binding]; other site 866345003338 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 866345003339 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 866345003340 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 866345003341 Walker A motif; other site 866345003342 ATP binding site [chemical binding]; other site 866345003343 Walker B motif; other site 866345003344 elongation factor P; Validated; Region: PRK00529 866345003345 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 866345003346 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 866345003347 RNA binding site [nucleotide binding]; other site 866345003348 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 866345003349 RNA binding site [nucleotide binding]; other site 866345003350 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 866345003351 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 866345003352 intersubunit interface [polypeptide binding]; other site 866345003353 active site 866345003354 zinc binding site [ion binding]; other site 866345003355 Na+ binding site [ion binding]; other site 866345003356 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 866345003357 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866345003358 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 866345003359 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 866345003360 potential frameshift: common BLAST hit: gi|15644801|ref|NP_206971.1| molybdopterin biosynthesis protein (moeA) 866345003361 MoeA N-terminal region (domain I and II); Region: MoeA_N; pfam03453 866345003362 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 866345003363 peptide chain release factor 2; Region: prfB; TIGR00020 866345003364 This domain is found in peptide chain release factors; Region: PCRF; smart00937 866345003365 RF-1 domain; Region: RF-1; pfam00472 866345003366 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 866345003367 Peptidase family U32; Region: Peptidase_U32; pfam01136 866345003368 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866345003369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866345003370 active site 866345003371 phosphorylation site [posttranslational modification] 866345003372 intermolecular recognition site; other site 866345003373 dimerization interface [polypeptide binding]; other site 866345003374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866345003375 DNA binding site [nucleotide binding] 866345003376 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 866345003377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866345003378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866345003379 dimer interface [polypeptide binding]; other site 866345003380 phosphorylation site [posttranslational modification] 866345003381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866345003382 ATP binding site [chemical binding]; other site 866345003383 Mg2+ binding site [ion binding]; other site 866345003384 G-X-G motif; other site 866345003385 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 866345003386 dimer interface [polypeptide binding]; other site 866345003387 active site 866345003388 Schiff base residues; other site 866345003389 hypothetical protein; Provisional; Region: PRK12378 866345003390 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345003391 Sel1-like repeats; Region: SEL1; smart00671 866345003392 Sel1-like repeats; Region: SEL1; smart00671 866345003393 Sel1-like repeats; Region: SEL1; smart00671 866345003394 Sel1-like repeats; Region: SEL1; smart00671 866345003395 Sel1-like repeats; Region: SEL1; smart00671 866345003396 Sel1-like repeats; Region: SEL1; smart00671 866345003397 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 866345003398 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 866345003399 Ligand binding site; other site 866345003400 metal-binding site 866345003401 Cache domain; Region: Cache_1; pfam02743 866345003402 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 866345003403 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 866345003404 ADP binding site [chemical binding]; other site 866345003405 magnesium binding site [ion binding]; other site 866345003406 putative shikimate binding site; other site 866345003407 AMIN domain; Region: AMIN; pfam11741 866345003408 enolase; Provisional; Region: eno; PRK00077 866345003409 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 866345003410 dimer interface [polypeptide binding]; other site 866345003411 metal binding site [ion binding]; metal-binding site 866345003412 substrate binding pocket [chemical binding]; other site 866345003413 recombinase A; Provisional; Region: recA; PRK09354 866345003414 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 866345003415 hexamer interface [polypeptide binding]; other site 866345003416 Walker A motif; other site 866345003417 ATP binding site [chemical binding]; other site 866345003418 Walker B motif; other site 866345003419 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 866345003420 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 866345003421 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 866345003422 Cytochrome c; Region: Cytochrom_C; pfam00034 866345003423 Cytochrome c; Region: Cytochrom_C; pfam00034 866345003424 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 866345003425 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 866345003426 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 866345003427 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 866345003428 Low-spin heme binding site [chemical binding]; other site 866345003429 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 866345003430 D-pathway; other site 866345003431 Putative water exit pathway; other site 866345003432 Binuclear center (active site) [active] 866345003433 K-pathway; other site 866345003434 Putative proton exit pathway; other site 866345003435 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 866345003436 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 866345003437 transmembrane helices; other site 866345003438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 866345003439 DNA glycosylase MutY; Provisional; Region: PRK13910 866345003440 minor groove reading motif; other site 866345003441 helix-hairpin-helix signature motif; other site 866345003442 substrate binding pocket [chemical binding]; other site 866345003443 active site 866345003444 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 866345003445 DNA binding and oxoG recognition site [nucleotide binding] 866345003446 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 866345003447 L-lactate permease; Region: Lactate_perm; pfam02652 866345003448 L-lactate transport; Region: lctP; TIGR00795 866345003449 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 866345003450 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 866345003451 Cysteine-rich domain; Region: CCG; pfam02754 866345003452 Cysteine-rich domain; Region: CCG; pfam02754 866345003453 iron-sulfur cluster-binding protein; Region: TIGR00273 866345003454 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 866345003455 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 866345003456 Uncharacterized conserved protein [Function unknown]; Region: COG1556 866345003457 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 866345003458 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 866345003459 catalytic triad [active] 866345003460 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 866345003461 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 866345003462 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 866345003463 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 866345003464 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 866345003465 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 866345003466 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 866345003467 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 866345003468 active site 866345003469 catalytic residues [active] 866345003470 DNA binding site [nucleotide binding] 866345003471 Int/Topo IB signature motif; other site 866345003472 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 866345003473 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 866345003474 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 866345003475 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 866345003476 DpnII restriction endonuclease; Region: DpnII; pfam04556 866345003477 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 866345003478 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866345003479 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003480 potential frameshift: common BLAST hit: gi|188526899|ref|YP_001909586.1| alpha-1,2-fucosyltransferase 866345003481 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 866345003482 GDP-Fucose binding site [chemical binding]; other site 866345003483 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 866345003484 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 866345003485 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 866345003486 putative ligand binding site [chemical binding]; other site 866345003487 putative NAD binding site [chemical binding]; other site 866345003488 catalytic site [active] 866345003489 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 866345003490 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 866345003491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345003492 catalytic residue [active] 866345003493 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 866345003494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 866345003495 dimer interface [polypeptide binding]; other site 866345003496 putative CheW interface [polypeptide binding]; other site 866345003497 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 866345003498 Ligand Binding Site [chemical binding]; other site 866345003499 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003500 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866345003501 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 866345003502 metal-binding site 866345003503 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 866345003504 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 866345003505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 866345003506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 866345003507 dimer interface [polypeptide binding]; other site 866345003508 putative CheW interface [polypeptide binding]; other site 866345003509 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 866345003510 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 866345003511 active site 866345003512 metal binding site [ion binding]; metal-binding site 866345003513 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 866345003514 S-ribosylhomocysteinase; Provisional; Region: PRK02260 866345003515 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 866345003516 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866345003517 homodimer interface [polypeptide binding]; other site 866345003518 substrate-cofactor binding pocket; other site 866345003519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345003520 catalytic residue [active] 866345003521 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 866345003522 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 866345003523 dimer interface [polypeptide binding]; other site 866345003524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866345003525 catalytic residue [active] 866345003526 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 866345003527 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 866345003528 nucleotide binding site [chemical binding]; other site 866345003529 NEF interaction site [polypeptide binding]; other site 866345003530 SBD interface [polypeptide binding]; other site 866345003531 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 866345003532 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 866345003533 dimer interface [polypeptide binding]; other site 866345003534 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 866345003535 heat-inducible transcription repressor; Provisional; Region: PRK03911 866345003536 hypothetical protein; Provisional; Region: PRK05834 866345003537 intersubunit interface [polypeptide binding]; other site 866345003538 active site 866345003539 Zn2+ binding site [ion binding]; other site 866345003540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 866345003541 flagellin B; Provisional; Region: PRK13588 866345003542 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 866345003543 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 866345003544 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 866345003545 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 866345003546 DNA topoisomerase I; Validated; Region: PRK05582 866345003547 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 866345003548 active site 866345003549 interdomain interaction site; other site 866345003550 putative metal-binding site [ion binding]; other site 866345003551 nucleotide binding site [chemical binding]; other site 866345003552 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 866345003553 domain I; other site 866345003554 DNA binding groove [nucleotide binding] 866345003555 phosphate binding site [ion binding]; other site 866345003556 domain II; other site 866345003557 domain III; other site 866345003558 nucleotide binding site [chemical binding]; other site 866345003559 catalytic site [active] 866345003560 domain IV; other site 866345003561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 866345003562 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 866345003563 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 866345003564 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 866345003565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345003566 FeS/SAM binding site; other site 866345003567 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 866345003568 phosphoenolpyruvate synthase; Validated; Region: PRK06464 866345003569 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 866345003570 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 866345003571 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 866345003572 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 866345003573 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 866345003574 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 866345003575 active site 866345003576 dimer interface [polypeptide binding]; other site 866345003577 motif 1; other site 866345003578 motif 2; other site 866345003579 motif 3; other site 866345003580 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 866345003581 anticodon binding site; other site 866345003582 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 866345003583 translation initiation factor IF-3; Region: infC; TIGR00168 866345003584 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 866345003585 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 866345003586 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 866345003587 23S rRNA binding site [nucleotide binding]; other site 866345003588 L21 binding site [polypeptide binding]; other site 866345003589 L13 binding site [polypeptide binding]; other site 866345003590 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003591 potential frameshift: common BLAST hit: gi|15645068|ref|NP_207238.1| DNA topoisomerase I (topA) 866345003592 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 866345003593 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 866345003594 nucleotide binding site [chemical binding]; other site 866345003595 domain II; other site 866345003596 domain IV; other site 866345003597 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 866345003598 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 866345003599 active site 866345003600 interdomain interaction site; other site 866345003601 putative metal-binding site [ion binding]; other site 866345003602 nucleotide binding site [chemical binding]; other site 866345003603 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 866345003604 domain I; other site 866345003605 DNA binding groove [nucleotide binding] 866345003606 phosphate binding site [ion binding]; other site 866345003607 domain III; other site 866345003608 catalytic site [active] 866345003609 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 866345003610 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 866345003611 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 866345003612 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 866345003613 Toprim-like; Region: Toprim_2; pfam13155 866345003614 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 866345003615 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 866345003616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866345003617 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 866345003618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866345003619 DNA binding residues [nucleotide binding] 866345003620 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 866345003621 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 866345003622 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 866345003623 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 866345003624 NlpC/P60 family; Region: NLPC_P60; cl17555 866345003625 Predicted dehydrogenase [General function prediction only]; Region: COG0579 866345003626 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 866345003627 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 866345003628 23S rRNA interface [nucleotide binding]; other site 866345003629 L3 interface [polypeptide binding]; other site 866345003630 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 866345003631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 866345003632 dimer interface [polypeptide binding]; other site 866345003633 putative CheW interface [polypeptide binding]; other site 866345003634 potential frameshift: common BLAST hit: gi|210134284|ref|YP_002300723.1| outer membrane protein HorA 866345003635 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003636 peptide chain release factor 1; Validated; Region: prfA; PRK00591 866345003637 This domain is found in peptide chain release factors; Region: PCRF; smart00937 866345003638 RF-1 domain; Region: RF-1; pfam00472 866345003639 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 866345003640 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 866345003641 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 866345003642 active site 866345003643 substrate binding site [chemical binding]; other site 866345003644 metal binding site [ion binding]; metal-binding site 866345003645 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 866345003646 urease subunit alpha; Provisional; Region: PRK13986 866345003647 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 866345003648 alpha-gamma subunit interface [polypeptide binding]; other site 866345003649 beta-gamma subunit interface [polypeptide binding]; other site 866345003650 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 866345003651 gamma-beta subunit interface [polypeptide binding]; other site 866345003652 alpha-beta subunit interface [polypeptide binding]; other site 866345003653 urease subunit beta; Provisional; Region: ureB; PRK13985 866345003654 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 866345003655 subunit interactions [polypeptide binding]; other site 866345003656 active site 866345003657 flap region; other site 866345003658 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 866345003659 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 866345003660 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 866345003661 dimer interface [polypeptide binding]; other site 866345003662 catalytic residues [active] 866345003663 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 866345003664 UreF; Region: UreF; pfam01730 866345003665 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 866345003666 G1 box; other site 866345003667 GTP/Mg2+ binding site [chemical binding]; other site 866345003668 G2 box; other site 866345003669 Switch I region; other site 866345003670 G3 box; other site 866345003671 Switch II region; other site 866345003672 G4 box; other site 866345003673 G5 box; other site 866345003674 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 866345003675 potential frameshift: common BLAST hit: gi|108562492|ref|YP_626808.1| ATP-binding protein 866345003676 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 866345003677 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 866345003678 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 866345003679 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 866345003680 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 866345003681 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 866345003682 Proline dehydrogenase; Region: Pro_dh; pfam01619 866345003683 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 866345003684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 866345003685 Glutamate binding site [chemical binding]; other site 866345003686 NAD binding site [chemical binding]; other site 866345003687 catalytic residues [active] 866345003688 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 866345003689 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 866345003690 Na binding site [ion binding]; other site 866345003691 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345003692 cofactor binding site; other site 866345003693 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 866345003694 active site 866345003695 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 866345003696 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345003697 cofactor binding site; other site 866345003698 DNA binding site [nucleotide binding] 866345003699 substrate interaction site [chemical binding]; other site 866345003700 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345003701 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 866345003702 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003703 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957 866345003704 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 866345003705 Acylphosphatase; Region: Acylphosphatase; pfam00708 866345003706 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 866345003707 HypF finger; Region: zf-HYPF; pfam07503 866345003708 HypF finger; Region: zf-HYPF; pfam07503 866345003709 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 866345003710 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 866345003711 dimerization interface [polypeptide binding]; other site 866345003712 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 866345003713 ATP binding site [chemical binding]; other site 866345003714 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 866345003715 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 866345003716 NADP binding site [chemical binding]; other site 866345003717 active site 866345003718 putative substrate binding site [chemical binding]; other site 866345003719 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 866345003720 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 866345003721 NADP-binding site; other site 866345003722 homotetramer interface [polypeptide binding]; other site 866345003723 substrate binding site [chemical binding]; other site 866345003724 homodimer interface [polypeptide binding]; other site 866345003725 active site 866345003726 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 866345003727 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 866345003728 Substrate binding site; other site 866345003729 Cupin domain; Region: Cupin_2; cl17218 866345003730 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 866345003731 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 866345003732 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 866345003733 VirB7 interaction site; other site 866345003734 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 866345003735 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 866345003736 PDZ domain; Region: PDZ_2; pfam13180 866345003737 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 866345003738 hypothetical protein; Provisional; Region: PRK03762 866345003739 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 866345003740 tetramerization interface [polypeptide binding]; other site 866345003741 active site 866345003742 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 866345003743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345003744 Walker A motif; other site 866345003745 ATP binding site [chemical binding]; other site 866345003746 Walker B motif; other site 866345003747 arginine finger; other site 866345003748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345003749 Walker A motif; other site 866345003750 ATP binding site [chemical binding]; other site 866345003751 Walker B motif; other site 866345003752 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 866345003753 Uncharacterized conserved protein [Function unknown]; Region: COG2127 866345003754 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866345003755 Ligand Binding Site [chemical binding]; other site 866345003756 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 866345003757 AAA domain; Region: AAA_26; pfam13500 866345003758 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 866345003759 isocitrate dehydrogenase; Validated; Region: PRK07362 866345003760 isocitrate dehydrogenase; Reviewed; Region: PRK07006 866345003761 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 866345003762 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 866345003763 dimer interface [polypeptide binding]; other site 866345003764 active site 866345003765 citrylCoA binding site [chemical binding]; other site 866345003766 NADH binding [chemical binding]; other site 866345003767 cationic pore residues; other site 866345003768 oxalacetate/citrate binding site [chemical binding]; other site 866345003769 coenzyme A binding site [chemical binding]; other site 866345003770 catalytic triad [active] 866345003771 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 866345003772 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 866345003773 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345003774 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866345003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 866345003776 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 866345003777 ATP binding site [chemical binding]; other site 866345003778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866345003779 putative Mg++ binding site [ion binding]; other site 866345003780 biotin synthase; Provisional; Region: PRK08508 866345003781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345003782 FeS/SAM binding site; other site 866345003783 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 866345003784 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 866345003785 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345003786 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345003787 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345003788 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345003789 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 866345003790 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 866345003791 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 866345003792 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 866345003793 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 866345003794 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 866345003795 Ligand binding site; other site 866345003796 metal-binding site 866345003797 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 866345003798 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 866345003799 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 866345003800 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 866345003801 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 866345003802 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 866345003803 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 866345003804 Walker A motif/ATP binding site; other site 866345003805 Walker B motif; other site 866345003806 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 866345003807 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 866345003808 ATP binding site [chemical binding]; other site 866345003809 Walker A motif; other site 866345003810 hexamer interface [polypeptide binding]; other site 866345003811 Walker B motif; other site 866345003812 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 866345003813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866345003814 active site 866345003815 HIGH motif; other site 866345003816 nucleotide binding site [chemical binding]; other site 866345003817 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 866345003818 active site 866345003819 KMSKS motif; other site 866345003820 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 866345003821 tRNA binding surface [nucleotide binding]; other site 866345003822 anticodon binding site; other site 866345003823 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 866345003824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866345003825 RNA binding surface [nucleotide binding]; other site 866345003826 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 866345003827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866345003828 FeS/SAM binding site; other site 866345003829 KpsF/GutQ family protein; Region: kpsF; TIGR00393 866345003830 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 866345003831 putative active site [active] 866345003832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 866345003833 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 866345003834 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866345003835 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 866345003836 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 866345003837 dimethyladenosine transferase; Region: ksgA; TIGR00755 866345003838 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345003839 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345003840 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345003841 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 866345003842 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 866345003843 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 866345003844 active site 866345003845 substrate binding site [chemical binding]; other site 866345003846 cosubstrate binding site; other site 866345003847 catalytic site [active] 866345003848 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 866345003849 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 866345003850 tandem repeat interface [polypeptide binding]; other site 866345003851 oligomer interface [polypeptide binding]; other site 866345003852 active site residues [active] 866345003853 TIR domain; Region: TIR_2; pfam13676 866345003854 Uncharacterized conserved protein [Function unknown]; Region: COG2433 866345003855 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 866345003856 active site 866345003857 carbon storage regulator; Provisional; Region: PRK00568 866345003858 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 866345003859 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 866345003860 SmpB-tmRNA interface; other site 866345003861 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 866345003862 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 866345003863 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 866345003864 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 866345003865 ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188 866345003866 hypothetical protein; Provisional; Region: PRK14374 866345003867 membrane protein insertase; Provisional; Region: PRK01318 866345003868 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 866345003869 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 866345003870 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 866345003871 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 866345003872 trmE is a tRNA modification GTPase; Region: trmE; cd04164 866345003873 G1 box; other site 866345003874 GTP/Mg2+ binding site [chemical binding]; other site 866345003875 Switch I region; other site 866345003876 G2 box; other site 866345003877 Switch II region; other site 866345003878 G3 box; other site 866345003879 G4 box; other site 866345003880 G5 box; other site 866345003881 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 866345003882 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003883 LPP20 lipoprotein; Region: LPP20; pfam02169 866345003884 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 866345003885 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866345003886 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866345003887 catalytic residues [active] 866345003888 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 866345003889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866345003890 RNA binding surface [nucleotide binding]; other site 866345003891 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 866345003892 active site 866345003893 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 866345003894 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 866345003895 active site 866345003896 PHP Thumb interface [polypeptide binding]; other site 866345003897 metal binding site [ion binding]; metal-binding site 866345003898 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 866345003899 generic binding surface I; other site 866345003900 generic binding surface II; other site 866345003901 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 866345003902 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 866345003903 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 866345003904 mce related protein; Region: MCE; pfam02470 866345003905 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 866345003906 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 866345003907 Walker A/P-loop; other site 866345003908 ATP binding site [chemical binding]; other site 866345003909 Q-loop/lid; other site 866345003910 ABC transporter signature motif; other site 866345003911 Walker B; other site 866345003912 D-loop; other site 866345003913 H-loop/switch region; other site 866345003914 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 866345003915 conserved hypothetical integral membrane protein; Region: TIGR00056 866345003916 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003917 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 866345003918 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 866345003919 homodimer interface [polypeptide binding]; other site 866345003920 substrate-cofactor binding pocket; other site 866345003921 catalytic residue [active] 866345003922 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345003923 DNA polymerase I; Region: pola; TIGR00593 866345003924 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 866345003925 active site 866345003926 metal binding site 1 [ion binding]; metal-binding site 866345003927 putative 5' ssDNA interaction site; other site 866345003928 metal binding site 3; metal-binding site 866345003929 metal binding site 2 [ion binding]; metal-binding site 866345003930 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 866345003931 putative DNA binding site [nucleotide binding]; other site 866345003932 putative metal binding site [ion binding]; other site 866345003933 3'-5' exonuclease; Region: 35EXOc; smart00474 866345003934 active site 866345003935 substrate binding site [chemical binding]; other site 866345003936 catalytic site [active] 866345003937 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 866345003938 active site 866345003939 DNA binding site [nucleotide binding] 866345003940 catalytic site [active] 866345003941 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345003942 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345003943 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866345003944 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 866345003945 thymidylate kinase; Validated; Region: tmk; PRK00698 866345003946 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 866345003947 TMP-binding site; other site 866345003948 ATP-binding site [chemical binding]; other site 866345003949 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 866345003950 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 866345003951 active site 866345003952 (T/H)XGH motif; other site 866345003953 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 866345003954 Flavoprotein; Region: Flavoprotein; pfam02441 866345003955 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 866345003956 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 866345003957 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 866345003958 Part of AAA domain; Region: AAA_19; pfam13245 866345003959 Family description; Region: UvrD_C_2; pfam13538 866345003960 TPR repeat; Region: TPR_11; pfam13414 866345003961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866345003962 TPR motif; other site 866345003963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866345003964 binding surface 866345003965 TPR motif; other site 866345003966 seryl-tRNA synthetase; Provisional; Region: PRK05431 866345003967 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 866345003968 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 866345003969 dimer interface [polypeptide binding]; other site 866345003970 active site 866345003971 motif 1; other site 866345003972 motif 2; other site 866345003973 motif 3; other site 866345003974 Predicted amidohydrolase [General function prediction only]; Region: COG0388 866345003975 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 866345003976 active site 866345003977 catalytic triad [active] 866345003978 dimer interface [polypeptide binding]; other site 866345003979 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14065 866345003980 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 866345003981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345003982 S-adenosylmethionine binding site [chemical binding]; other site 866345003983 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 866345003984 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 866345003985 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 866345003986 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 866345003987 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 866345003988 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 866345003989 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 866345003990 ABC-2 type transporter; Region: ABC2_membrane; cl17235 866345003991 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866345003992 HlyD family secretion protein; Region: HlyD_3; pfam13437 866345003993 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 866345003994 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 866345003995 Domain of unknown function DUF21; Region: DUF21; pfam01595 866345003996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 866345003997 Transporter associated domain; Region: CorC_HlyC; smart01091 866345003998 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 866345003999 Phosphate transporter family; Region: PHO4; pfam01384 866345004000 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 866345004001 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 866345004002 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866345004003 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866345004004 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 866345004005 putative active site [active] 866345004006 transaldolase; Provisional; Region: PRK03903 866345004007 catalytic residue [active] 866345004008 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 866345004009 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 866345004010 5S rRNA interface [nucleotide binding]; other site 866345004011 CTC domain interface [polypeptide binding]; other site 866345004012 L16 interface [polypeptide binding]; other site 866345004013 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 866345004014 putative active site [active] 866345004015 catalytic residue [active] 866345004016 Predicted permeases [General function prediction only]; Region: COG0795 866345004017 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 866345004018 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 866345004019 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 866345004020 potential frameshift: common BLAST hit: gi|208435368|ref|YP_002267034.1| type II adenine specific DNA methyltransferase 866345004021 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 866345004022 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 866345004023 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 866345004024 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345004025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 866345004026 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 866345004027 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 866345004028 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866345004029 metal-binding site [ion binding] 866345004030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866345004031 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866345004032 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 866345004033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866345004034 S-adenosylmethionine binding site [chemical binding]; other site 866345004035 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 866345004036 catalytic motif [active] 866345004037 Zn binding site [ion binding]; other site 866345004038 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 866345004039 RibD C-terminal domain; Region: RibD_C; cl17279 866345004040 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 866345004041 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 866345004042 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 866345004043 NAD(P) binding pocket [chemical binding]; other site 866345004044 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 866345004045 4Fe-4S binding domain; Region: Fer4_5; pfam12801 866345004046 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 866345004047 acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023 866345004048 FolB domain; Region: folB_dom; TIGR00526 866345004049 active site 866345004050 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 866345004051 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345004052 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866345004053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866345004054 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 866345004055 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 866345004056 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 866345004057 NusA N-terminal domain; Region: NusA_N; pfam08529 866345004058 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 866345004059 RNA binding site [nucleotide binding]; other site 866345004060 homodimer interface [polypeptide binding]; other site 866345004061 NusA-like KH domain; Region: KH_5; pfam13184 866345004062 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 866345004063 G-X-X-G motif; other site 866345004064 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 866345004065 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 866345004066 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 866345004067 putative active site [active] 866345004068 putative NTP binding site [chemical binding]; other site 866345004069 putative nucleic acid binding site [nucleotide binding]; other site 866345004070 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 866345004071 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 866345004072 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 866345004073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 866345004074 ABC transporter signature motif; other site 866345004075 Walker B; other site 866345004076 D-loop; other site 866345004077 H-loop/switch region; other site 866345004078 Restriction endonuclease [Defense mechanisms]; Region: COG3587 866345004079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345004080 ATP binding site [chemical binding]; other site 866345004081 putative Mg++ binding site [ion binding]; other site 866345004082 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866345004083 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866345004084 DNA methylase; Region: N6_N4_Mtase; cl17433 866345004085 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345004086 DNA methylase; Region: N6_N4_Mtase; pfam01555 866345004087 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 866345004088 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 866345004089 ssDNA binding site; other site 866345004090 generic binding surface II; other site 866345004091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345004092 ATP binding site [chemical binding]; other site 866345004093 putative Mg++ binding site [ion binding]; other site 866345004094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345004095 nucleotide binding region [chemical binding]; other site 866345004096 ATP-binding site [chemical binding]; other site 866345004097 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345004098 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 866345004099 active site 866345004100 putative catalytic site [active] 866345004101 DNA binding site [nucleotide binding] 866345004102 putative phosphate binding site [ion binding]; other site 866345004103 metal binding site A [ion binding]; metal-binding site 866345004104 AP binding site [nucleotide binding]; other site 866345004105 metal binding site B [ion binding]; metal-binding site 866345004106 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 866345004107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866345004108 Walker A motif; other site 866345004109 ATP binding site [chemical binding]; other site 866345004110 Walker B motif; other site 866345004111 arginine finger; other site 866345004112 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 866345004113 DnaA box-binding interface [nucleotide binding]; other site 866345004114 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 866345004115 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 866345004116 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 866345004117 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 866345004118 glutaminase active site [active] 866345004119 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 866345004120 dimer interface [polypeptide binding]; other site 866345004121 active site 866345004122 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 866345004123 dimer interface [polypeptide binding]; other site 866345004124 active site 866345004125 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 866345004126 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866345004127 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866345004128 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866345004129 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866345004130 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 866345004131 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866345004132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345004133 ATP binding site [chemical binding]; other site 866345004134 putative Mg++ binding site [ion binding]; other site 866345004135 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 866345004136 Protein of unknown function DUF45; Region: DUF45; pfam01863 866345004137 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 866345004138 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866345004139 N-terminal plug; other site 866345004140 ligand-binding site [chemical binding]; other site 866345004141 Arginase family; Region: Arginase; cd09989 866345004142 active site 866345004143 Mn binding site [ion binding]; other site 866345004144 oligomer interface [polypeptide binding]; other site 866345004145 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 866345004146 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 866345004147 hexamer interface [polypeptide binding]; other site 866345004148 ligand binding site [chemical binding]; other site 866345004149 putative active site [active] 866345004150 NAD(P) binding site [chemical binding]; other site 866345004151 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345004152 Protein of unknown function DUF262; Region: DUF262; pfam03235 866345004153 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866345004154 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866345004155 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 866345004156 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 866345004157 ATP-NAD kinase; Region: NAD_kinase; pfam01513 866345004158 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 866345004159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866345004160 Walker A/P-loop; other site 866345004161 ATP binding site [chemical binding]; other site 866345004162 Q-loop/lid; other site 866345004163 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 866345004164 ABC transporter signature motif; other site 866345004165 Walker B; other site 866345004166 D-loop; other site 866345004167 H-loop/switch region; other site 866345004168 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 866345004169 Domain of unknown function (DUF814); Region: DUF814; pfam05670 866345004170 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 866345004171 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 866345004172 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 866345004173 active site 866345004174 catalytic site [active] 866345004175 substrate binding site [chemical binding]; other site 866345004176 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 866345004177 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 866345004178 substrate binding site [chemical binding]; other site 866345004179 hexamer interface [polypeptide binding]; other site 866345004180 metal binding site [ion binding]; metal-binding site 866345004181 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 866345004182 active site 866345004183 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866345004184 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 866345004185 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866345004186 cofactor binding site; other site 866345004187 DNA binding site [nucleotide binding] 866345004188 substrate interaction site [chemical binding]; other site 866345004189 elongation factor Ts; Provisional; Region: tsf; PRK09377 866345004190 UBA/TS-N domain; Region: UBA; pfam00627 866345004191 Elongation factor TS; Region: EF_TS; pfam00889 866345004192 Elongation factor TS; Region: EF_TS; pfam00889 866345004193 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 866345004194 rRNA interaction site [nucleotide binding]; other site 866345004195 S8 interaction site; other site 866345004196 putative laminin-1 binding site; other site 866345004197 putative recombination protein RecB; Provisional; Region: PRK13909 866345004198 Family description; Region: UvrD_C_2; pfam13538 866345004199 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 866345004200 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856 866345004201 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 866345004202 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 866345004203 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 866345004204 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 866345004205 Protein export membrane protein; Region: SecD_SecF; pfam02355 866345004206 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 866345004207 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 866345004208 HIGH motif; other site 866345004209 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 866345004210 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 866345004211 active site 866345004212 KMSKS motif; other site 866345004213 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 866345004214 tRNA binding surface [nucleotide binding]; other site 866345004215 anticodon binding site; other site 866345004216 Lipopolysaccharide-assembly; Region: LptE; pfam04390 866345004217 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 866345004218 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866345004219 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866345004220 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866345004221 Peptidase family M23; Region: Peptidase_M23; pfam01551 866345004222 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866345004223 Peptidase family M23; Region: Peptidase_M23; pfam01551 866345004224 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 866345004225 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 866345004226 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 866345004227 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 866345004228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866345004229 ATP binding site [chemical binding]; other site 866345004230 putative Mg++ binding site [ion binding]; other site 866345004231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866345004232 nucleotide binding region [chemical binding]; other site 866345004233 ATP-binding site [chemical binding]; other site 866345004234 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 866345004235 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 866345004236 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 866345004237 [2Fe-2S] cluster binding site [ion binding]; other site 866345004238 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 866345004239 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 866345004240 intrachain domain interface; other site 866345004241 interchain domain interface [polypeptide binding]; other site 866345004242 heme bH binding site [chemical binding]; other site 866345004243 Qi binding site; other site 866345004244 heme bL binding site [chemical binding]; other site 866345004245 Qo binding site; other site 866345004246 interchain domain interface [polypeptide binding]; other site 866345004247 intrachain domain interface; other site 866345004248 Qi binding site; other site 866345004249 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 866345004250 Qo binding site; other site 866345004251 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 866345004252 Cytochrome c; Region: Cytochrom_C; pfam00034 866345004253 Cytochrome c; Region: Cytochrom_C; cl11414 866345004254 Predicted ATPases [General function prediction only]; Region: COG1106 866345004255 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 866345004256 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 866345004257 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 866345004258 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 866345004259 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 866345004260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 866345004261 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 866345004262 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 866345004263 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 866345004264 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 866345004265 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 866345004266 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 866345004267 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 866345004268 dimer interface [polypeptide binding]; other site 866345004269 decamer (pentamer of dimers) interface [polypeptide binding]; other site 866345004270 catalytic triad [active] 866345004271 peroxidatic and resolving cysteines [active] 866345004272 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 866345004273 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 866345004274 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 866345004275 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 866345004276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 866345004277 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 866345004278 G1 box; other site 866345004279 GTP/Mg2+ binding site [chemical binding]; other site 866345004280 Switch I region; other site 866345004281 G2 box; other site 866345004282 G3 box; other site 866345004283 Switch II region; other site 866345004284 G4 box; other site 866345004285 G5 box; other site 866345004286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 866345004287 OstA-like protein; Region: OstA; pfam03968 866345004288 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 866345004289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866345004290 active site 866345004291 motif I; other site 866345004292 motif II; other site 866345004293 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 866345004294 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 866345004295 Sporulation related domain; Region: SPOR; pfam05036 866345004296 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866345004297 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866345004298 catalytic residue [active] 866345004299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866345004300 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 866345004301 active site 866345004302 riboflavin synthase, alpha subunit; Region: ribE; TIGR00187 866345004303 Lumazine binding domain; Region: Lum_binding; pfam00677 866345004304 Lumazine binding domain; Region: Lum_binding; pfam00677 866345004305 flhB C-terminus-related protein; Region: flhB_rel; TIGR00789 866345004306 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 866345004307 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 866345004308 Walker A/P-loop; other site 866345004309 ATP binding site [chemical binding]; other site 866345004310 Q-loop/lid; other site 866345004311 ABC transporter signature motif; other site 866345004312 Walker B; other site 866345004313 D-loop; other site 866345004314 H-loop/switch region; other site 866345004315 NIL domain; Region: NIL; pfam09383 866345004316 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 866345004317 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 866345004318 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 866345004319 active site 866345004320 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 866345004321 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 866345004322 Mg++ binding site [ion binding]; other site 866345004323 putative catalytic motif [active] 866345004324 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 866345004325 active site 866345004326 hydrophilic channel; other site 866345004327 dimerization interface [polypeptide binding]; other site 866345004328 catalytic residues [active] 866345004329 active site lid [active] 866345004330 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 866345004331 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 866345004332 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 866345004333 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 866345004334 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 866345004335 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 866345004336 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 866345004337 hypothetical protein; Provisional; Region: PRK10236 866345004338 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 866345004339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 866345004340 Fic family protein [Function unknown]; Region: COG3177 866345004341 Fic/DOC family; Region: Fic; pfam02661 866345004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866345004343 putative substrate translocation pore; other site 866345004344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866345004345 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 866345004346 ATP binding site [chemical binding]; other site 866345004347 substrate interface [chemical binding]; other site 866345004348 Initiator Replication protein; Region: Rep_3; pfam01051