-- dump date 20140619_113538 -- class Genbank::CDS -- table cds_note -- id note NP_222723.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_222724.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_222725.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis NP_222726.1 similar to H. pylori 26695 gene HP0004 NP_222727.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_222728.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_222729.1 similar to TIGR HP0009; expression of this protein is predicted to be regulated by slipped-strand repair at the (CT) dinucleotide repeat; length of the repeat has been artificially adjusted (addition of one dinucleotide) to give the full length protein NP_222730.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_222731.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_222732.1 synthesizes RNA primers at the replication forks NP_222733.1 similar to H. pylori 26695 gene HP0013 NP_222734.1 similar to H. pylori 26695 gene HP0014 NP_222735.1 similar to H. pylori 26695 gene HP0015 NP_222736.1 similar to H. pylori 26695 gene HP0016 NP_222737.1 similar to H. pylori 26695 gene HP0017 NP_222738.1 similar to H. pylori 26695 gene HP0018 NP_222739.1 similar to H. pylori 26695 gene HP0019 NP_222740.1 similar to H. pylori 26695 gene HP0020 NP_222741.1 inner membrane enzyme; removes 1-phosphate groups from a number of lipid A precursors which provides a point of attachment for to moieties such as phosphoethanolamine which is attached by HP0022 NP_222742.1 attaches phosphoethanolamine to lipid A at the 1 position of the disaccharide backbone in contrast to other gram-negative bacteria NP_222743.1 similar to H. pylori 26695 gene HP0025 NP_222744.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH NP_222745.1 similar to H. pylori 26695 gene HP0027 NP_222746.1 similar to H. pylori 26695 gene HP0028 NP_222747.1 similar to H. pylori 26695 gene HP0029 NP_222748.1 similar to H. pylori 26695 gene HP0030 NP_222749.1 similar to H. pylori 26695 gene HP0031 NP_222750.1 similar to H. pylori 26695 gene HP0032 NP_222751.1 similar to H. pylori 26695 gene HP0033 NP_222752.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_222753.1 similar to H. pylori 26695 gene HP0035 NP_222754.1 similar to H. pylori 26695 gene HP0036 NP_222755.1 similar to H. pylori 26695 gene HP0037 NP_222756.1 similar to H. pylori 26695 gene HP0038 NP_222757.1 similar to H. pylori 26695 gene HP0039 and HP0040 NP_222758.1 similar to H. pylori 26695 gene HP0041 and HP0042 NP_222759.1 similar to H. pylori 26695 gene HP0043 NP_222760.1 similar to H. pylori 26695 gene HP0044 NP_222761.1 similar to H. pylori 26695 gene HP0045 NP_222762.1 similar to H. pylori 26695 gene HP0047 NP_222763.1 similar to H. pylori 26695 gene HP0048 NP_222764.1 similar to H. pylori 26695 gene HP0049 NP_222765.1 similar to H. pylori 26695 gene HP0050 NP_222769.1 similar to H. pylori 26695 gene HP0055 NP_222770.1 similar to H. pylori 26695 gene HP0056 NP_222771.1 similar to H. pylori 26695 gene HP0057 NP_222772.1 similar to H. pylori 26695 gene HP0058 NP_222773.1 similar to H. pylori 26695 gene HP0058 NP_222774.1 similar to H. pylori 26695 gene HP0059 NP_222775.1 similar to H. pylori 26695 gene HP0060 NP_222776.1 similar to H. pylori 26695 gene HP0060 NP_222777.1 similar to H. pylori 26695 gene HP0060 NP_222778.1 similar to H. pylori 26695 gene HP0061 NP_222779.1 similar to H. pylori 26695 gene HP0062 NP_222780.1 similar to H. pylori 26695 gene HP0063 NP_222781.1 similar to H. pylori 26695 gene HP0064 NP_222782.1 similar to H. pylori 26695 gene HP0065 NP_222783.1 similar to H. pylori 26695 gene HP0066 NP_222784.1 similar to H. pylori 26695 gene HP0067 NP_222785.1 similar to H. pylori 26695 gene HP0068 NP_222786.1 similar to H. pylori 26695 gene HP0069 NP_222787.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_222788.1 similar to H. pylori 26695 gene HP0071 NP_222789.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureA(alpha) and 3 ureB (beta) subunits NP_222790.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureA(alpha) and 3 ureB (beta) subunits NP_222791.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_222792.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_222793.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_222794.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_222795.1 similar to H. pylori 26695 gene HP0078 and HP0079 NP_222796.1 similar to H. pylori 26695 gene HP0080 NP_222797.1 similar to H. pylori 26695 gene HP0082 NP_222798.1 forms a direct contact with the tRNA during translation NP_222799.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_222800.1 similar to H. pylori 26695 gene HP0085 NP_222801.1 similar to H. pylori 26695 gene HP0086 NP_222802.1 similar to H. pylori 26695 gene HP0087 NP_222803.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria NP_222804.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine NP_222805.1 similar to H. pylori 26695 gene HP0090 NP_222806.1 similar to H. pylori 26695 gene HP0092 NP_222807.1 similar to TIGR HP0094; expression of this protein is predicted to be regulated by slipped-strand repair at the (C) polynucleotide repeat; length of the repeat has been artificially adjusted (removal of one nucleotide) to give the full length protein NP_222808.1 similar to H. pylori 26695 gene HP0095 NP_222809.1 Involved in the metabolism of aromatic amino acids NP_222810.1 similar to H. pylori 26695 gene HP0097 NP_222811.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_222812.1 similar to H. pylori 26695 gene HP0099 NP_222813.1 similar to H. pylori 26695 gene HP0100 NP_222814.1 similar to H. pylori 26695 gene HP0101 NP_222815.1 similar to H. pylori 26695 gene HP0102 NP_222816.1 similar to H. pylori 26695 gene HP0103 NP_222817.1 similar to H. pylori 26695 gene HP0104 NP_222818.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_222819.1 catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine NP_222820.1 similar to H. pylori 26695 gene HP0107 NP_222821.1 similar to H. pylori 26695 gene HP0108 NP_222822.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_222823.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_222824.1 Acts as a negative regulator of the grpE-dnaK-dnaJ and groELS class I heat shock operons by preventing heat-shock induction NP_222825.1 similar to H. pylori 26695 gene HP0112 NP_222826.1 similar to H. pylori 26695 gene HP0113 NP_222827.1 similar to H. pylori 26695 gene HP0114 NP_222828.1 FlaB; structural flagella protein; in Helicobacter flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions NP_222829.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_222830.1 similar to H. pylori 26695 gene HP0117 NP_222831.1 similar to H. pylori 26695 gene HP0118 NP_222832.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_222833.1 similar to H. pylori 26695 gene HP0122 NP_222834.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_222835.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_222836.1 similar to H. pylori 26695 gene HP0125 NP_222837.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_222838.1 similar to H. pylori 26695 gene HP0127 NP_222839.1 similar to H. pylori 26695 gene HP0129 NP_222840.1 similar to H. pylori 26695 gene HP0130 NP_222841.1 similar to H. pylori 26695 gene HP0132 NP_222842.1 similar to H. pylori 26695 gene HP0133 NP_222843.1 similar to H. pylori 26695 gene HP0134 NP_222844.1 similar to H. pylori 26695 gene HP0135 NP_222845.1 similar to H. pylori 26695 gene HP0136 NP_222846.1 similar to H. pylori 26695 gene HP0137 NP_222847.1 similar to H. pylori 26695 gene HP0138 NP_222848.1 similar to H. pylori 26695 gene HP0139 NP_222849.1 similar to H. pylori 26695 gene HP0140 NP_222850.1 similar to H. pylori 26695 gene HP0141 NP_222851.1 similar to H. pylori 26695 gene HP0142 NP_222852.1 similar to H. pylori 26695 gene HP0143 NP_222853.1 CcoN; FixN NP_222854.1 CcoO; FixO NP_222855.1 similar to H. pylori 26695 gene HP0146 NP_222856.1 similar to H. pylori 26695 gene HP0147 NP_222857.1 similar to H. pylori 26695 gene HP0148 NP_222858.1 similar to H. pylori 26695 gene HP0149 NP_222859.1 similar to H. pylori 26695 gene HP0150 NP_222860.1 similar to H. pylori 26695 gene HP0151 NP_222861.1 similar to H. pylori 26695 gene HP0152 NP_222862.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_222863.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_222864.1 similar to H. pylori 26695 gene HP0155 NP_222865.1 similar to H. pylori 26695 gene HP0156 NP_222866.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_222867.1 similar to H. pylori 26695 gene HP0158 NP_222868.1 similar to H. pylori 26695 gene HP0159 NP_222869.1 similar to H. pylori 26695 gene HP0160 NP_222870.1 similar to H. pylori 26695 gene HP0162 NP_222871.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_222872.1 similar to H. pylori 26695 gene HP0164 and HP0165 NP_222873.1 similar to H. pylori 26695 gene HP0166 NP_222874.1 similar to H. pylori 26695 gene HP0167 NP_222875.1 similar to H. pylori 26695 gene HP0168 NP_222876.1 similar to H. pylori 26695 gene HP0169 NP_222877.1 similar to H. pylori 26695 gene HP0170 NP_222878.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_222879.1 similar to H. pylori 26695 gene HP0172 NP_222880.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus NP_222881.1 similar to H. pylori 26695 gene HP0174 NP_222882.1 similar to H. pylori 26695 gene HP0175 NP_222883.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_222884.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_222887.1 similar to H. pylori 26695 gene HP0178 NP_222888.1 similar to H. pylori 26695 gene HP0179 NP_222889.1 Transfers the fatty acyl group on membrane lipoproteins NP_222890.1 similar to H. pylori 26695 gene HP0181 NP_222891.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_222892.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_222893.1 similar to H. pylori 26695 gene HP0184 NP_222894.1 similar to H. pylori 26695 gene HP0185 NP_222895.1 similar to H. pylori 26695 gene HP0186, HP0187, and HP0188 NP_222896.1 similar to H. pylori 26695 gene HP0189 NP_222897.1 similar to H. pylori 26695 gene HP0190 NP_222898.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB NP_222899.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB NP_222900.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit NP_222901.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_222902.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_222903.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis NP_222904.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_222905.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_222906.1 similar to H. pylori 26695 gene HP0199 NP_222907.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_222908.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_222909.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_222910.1 similar to H. pylori 26695 gene HP0203 NP_222911.1 similar to H. pylori 26695 gene HP0204 NP_222912.1 similar to H. pylori 26695 gene HP0205 NP_222913.1 similar to H. pylori 26695 gene HP0206 NP_222914.1 similar to H. pylori 26695 gene HP0207 NP_222915.1 similar to TIGR HP0208; expression of this protein is predicted to be regulated by slipped-strand repair at the (AG) dinucleotide repeat; length of the repeat has been artificially adjusted (removal of one dinucleotide) to give the full length protein NP_222916.1 similar to H. pylori 26695 gene HP0209 NP_222917.1 molecular chaperone NP_222918.1 similar to H. pylori 26695 gene HP0211 NP_222919.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. NP_222920.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_222921.1 similar to H. pylori 26695 gene HP0214 NP_222922.1 similar to H. pylori 26695 gene HP0215 NP_222923.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_222924.1 similar to TIGR HP0217; expression of this protein is predicted to be regulated by slipped-strand repair at the two (G) polynucleotide repeats; length of the second repeat has been artificially adjusted (removal of one nucleotide) to give the full length protein NP_222925.1 similar to H. pylori 26695 gene HP0218 NP_222926.1 similar to H. pylori 26695 gene HP0219 NP_222927.1 catalyzes the removal of sulfur from cysteine to form alanine NP_222928.1 similar to H. pylori 26695 gene HP0221 NP_222929.1 similar to H. pylori 26695 gene HP0222 NP_222930.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_222931.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion NP_222932.1 similar to H. pylori 26695 gene HP0226 NP_222933.1 similar to H. pylori 26695 gene HP0227 NP_222934.1 similar to H. pylori 26695 gene HP0228 NP_222935.1 similar to H. pylori 26695 gene HP0229 NP_222936.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS NP_222937.1 similar to H. pylori 26695 gene HP0231 NP_222938.1 similar to H. pylori 26695 gene HP0232 NP_222939.1 similar to H. pylori 26695 gene HP0233 NP_222940.1 similar to H. pylori 26695 gene HP0234 NP_222941.1 similar to H. pylori 26695 gene HP0235 NP_222942.1 similar to H. pylori 26695 gene HP0236 NP_222943.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_222944.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_222945.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_222946.1 similar to H. pylori 26695 gene HP0240 NP_222947.1 similar to H. pylori 26695 gene HP0241 NP_222948.1 similar to H. pylori 26695 gene HP0242 NP_222949.1 similar to H. pylori 26695 gene HP0243 NP_222950.1 similar to H. pylori 26695 gene HP0244 NP_222951.1 similar to H. pylori 26695 gene HP0245 NP_222952.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum NP_222953.1 similar to H. pylori 26695 gene HP0247 NP_222954.1 similar to H. pylori 26695 gene HP0248 NP_222955.1 similar to H. pylori 26695 gene HP0249 NP_222956.1 similar to H. pylori 26695 gene HP0250 NP_222957.1 similar to H. pylori 26695 gene HP0251 NP_222958.1 similar to H. pylori 26695 gene HP0252 NP_222959.1 similar to H. pylori 26695 gene HP0253 and HP0254 NP_222960.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_222961.1 similar to H. pylori 26695 gene HP0256 NP_222962.1 similar to H. pylori 26695 gene HP0257 NP_222963.1 similar to H. pylori 26695 gene HP0258 NP_222964.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_222965.1 similar to H. pylori 26695 gene HP0260 NP_222966.1 similar to H. pylori 26695 gene HP0261 NP_222967.1 similar to H. pylori 26695 gene HP0262 NP_222968.1 similar to H. pylori 26695 gene HP0262 NP_222969.1 similar to H. pylori 26695 gene HP0263 NP_222970.1 similar to H. pylori 26695 gene HP0264 NP_222971.1 similar to H. pylori 26695 gene HP0265 NP_222972.1 similar to H. pylori 26695 gene HP0266 NP_222973.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline NP_222974.1 similar to H. pylori 26695 gene HP0268 NP_222975.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_222976.1 similar to H. pylori 26695 gene HP0270 NP_222977.1 similar to H. pylori 26695 gene HP0271 NP_222978.1 similar to H. pylori 26695 gene HP0272 NP_222979.1 similar to H. pylori 26695 gene HP0273 NP_222980.1 similar to H. pylori 26695 gene HP0274 NP_222981.1 similar to H. pylori 26695 gene HP0275 NP_222982.1 similar to H. pylori 26695 gene HP0276 NP_222983.1 similar to H. pylori 26695 gene HP0277 NP_222984.1 similar to H. pylori 26695 gene HP0278 NP_222985.1 similar to H. pylori 26695 gene HP0279 NP_222986.1 acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; essential for survival; plays a role in cell responses to environmental changes NP_222987.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_222988.1 similar to H. pylori 26695 gene HP0282 NP_222989.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_222990.1 similar to H. pylori 26695 gene HP0284 NP_222991.1 similar to H. pylori 26695 gene HP0285 NP_222992.1 similar to H. pylori 26695 gene HP0286 NP_222993.1 similar to H. pylori 26695 gene HP0287 NP_222994.1 similar to H. pylori 26695 gene HP0288 NP_222995.1 similar to H. pylori 26695 gene HP0289 NP_222996.1 similar to H. pylori 26695 gene HP0290 NP_222997.1 similar to H. pylori 26695 gene HP0291 NP_222998.1 similar to H. pylori 26695 gene HP0292 NP_222999.1 similar to H. pylori 26695 gene HP0293 NP_223000.1 aliphatic amidase; catalyzes the hydrolysis of short-chain aliphatic amides to their organic acids and can also transfer the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates NP_223001.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook NP_223002.1 similar to H. pylori 26695 gene HP0296 NP_223003.1 involved in the peptidyltransferase reaction during translation NP_223004.1 similar to H. pylori 26695 gene HP0298 NP_223005.1 similar to H. pylori 26695 gene HP0299 NP_223006.1 similar to H. pylori 26695 gene HP0301 NP_223007.1 similar to H. pylori 26695 gene HP0302 NP_223008.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_223009.1 similar to H. pylori 26695 gene HP0304 NP_223010.1 similar to H. pylori 26695 gene HP0305 NP_223011.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_223012.1 similar to H. pylori 26695 gene HP0307 NP_223013.1 similar to H. pylori 26695 gene HP0308 NP_223014.1 similar to H. pylori 26695 gene HP0309 NP_223015.1 similar to H. pylori 26695 gene HP0310 NP_223016.1 similar to H. pylori 26695 gene HP0311 NP_223017.1 similar to H. pylori 26695 gene HP0312 NP_223018.1 similar to H. pylori 26695 gene HP0313 NP_223019.1 similar to H. pylori 26695 gene HP0611 and HP0612 NP_223020.1 similar to H. pylori 26695 gene HP0613 NP_223021.1 similar to H. pylori 26695 gene HP0318 NP_223022.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_223023.1 similar to H. pylori 26695 gene HP0320 NP_223024.1 Essential for recycling GMP and indirectly, cGMP NP_223025.1 similar to H. pylori 26695 gene HP0322 NP_223026.1 membrane-associated cation-independent thermostable nuclease; preferentially cleaves ss-DNA; involved in DNA transformation NP_223027.1 similar to H. pylori 26695 gene HP0324 NP_223028.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod NP_223029.1 similar to H. pylori 26695 gene HP0327 NP_223030.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate NP_223031.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_223032.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_223033.1 similar to H. pylori 26695 gene HP0331 NP_223034.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell NP_223035.1 similar to H. pylori 26695 gene HP0333 NP_223036.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_223038.1 similar to H. pylori 26695 gene HP0337 NP_223039.1 similar to H. pylori 26695 gene HP0338 NP_223040.1 similar to H. pylori 26695 gene HP0347 NP_223041.1 similar to H. pylori 26695 gene HP0348 NP_223042.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_223043.1 similar to H. pylori 26695 gene HP0350 NP_223044.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod NP_223045.1 One of three proteins involved in switching the direction of the flagellar rotation NP_223046.1 binds to and inhibits the function of flagella specific ATPase FliI NP_223047.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_223048.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_223049.1 similar to H. pylori 26695 gene HP0356 NP_223052.1 similar to H. pylori 26695 gene HP1092 NP_223053.1 similar to H. pylori 26695 gene HP1091 NP_223054.1 similar to H. pylori 26695 gene HP1090 NP_223055.1 similar to H. pylori 26695 gene HP1089 NP_223056.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_223057.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_223058.1 similar to H. pylori 26695 gene HP1086 NP_223059.1 similar to H. pylori 26695 gene HP1085 NP_223060.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_223061.1 similar to H. pylori 26695 gene HP1083 NP_223062.1 similar to H. pylori 26695 gene HP1082 NP_223063.1 similar to H. pylori 26695 gene HP1081 NP_223064.1 similar to H. pylori 26695 gene HP1080 NP_223065.1 similar to H. pylori 26695 gene HP1079 NP_223066.1 similar to H. pylori 26695 gene HP1078 NP_223067.1 similar to H. pylori 26695 gene HP1077 NP_223068.1 similar to H. pylori 26695 gene HP1076 NP_223069.1 similar to H. pylori 26695 gene HP1075 NP_223070.1 similar to H. pylori 26695 gene HP1074 NP_223071.1 similar to H. pylori 26695 gene HP1073 NP_223072.1 similar to H. pylori 26695 gene HP1072 NP_223073.1 similar to H. pylori 26695 gene HP1071 NP_223074.1 similar to H. pylori 26695 gene HP1070 NP_223075.1 similar to H. pylori 26695 gene HP1069 NP_223076.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_223077.1 similar to H. pylori 26695 gene HP1067 NP_223078.1 similar to H. pylori 26695 gene HP1066 NP_223079.1 similar to H. pylori 26695 gene HP1065 NP_223080.1 similar to H. pylori 26695 gene HP1064 NP_223081.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_223082.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_223083.1 similar to H. pylori 26695 gene HP1061 NP_223084.1 mediates the export of protein precursors bearing twin-arginine signal peptides NP_223085.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_223086.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_223087.1 similar to H. pylori 26695 gene HP1057 NP_223088.1 similar to H. pylori 26695 gene HP1056 NP_223089.1 similar to H. pylori 26695 gene HP1055 NP_223090.1 similar to H. pylori 26695 gene HP1054 NP_223091.1 blocks the formation of polar Z-ring septums NP_223092.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis NP_223093.1 similar to H. pylori 26695 gene HP1051 NP_223094.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_223095.1 similar to H. pylori 26695 gene HP1049 NP_223096.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_223097.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_223098.1 similar to H. pylori 26695 gene HP1046 NP_223099.1 similar to H. pylori 26695 gene HP1044 NP_223100.1 similar to H. pylori 26695 gene HP1043 NP_223101.1 similar to H. pylori 26695 gene HP1042 NP_223102.1 membrane protein involved in the flagellar export apparatus NP_223103.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_223104.1 similar to H. pylori 26695 gene HP1039 NP_223105.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis NP_223106.1 similar to H. pylori 26695 gene HP1037 NP_223107.1 similar to H. pylori 26695 gene HP1036 NP_223108.1 positive regulator of class III flagellar genes NP_223109.1 similar to H. pylori 26695 gene HP1034 NP_223110.1 similar to H. pylori 26695 gene HP1033 NP_223111.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes NP_223112.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation NP_223113.1 One of three proteins involved in switching the direction of the flagellar rotation NP_223114.1 similar to H. pylori 26695 gene HP1029 NP_223115.1 similar to H. pylori 26695 gene HP1028 NP_223116.1 similar to H. pylori 26695 gene HP1027 NP_223117.1 similar to H. pylori 26695 gene HP1026 NP_223118.1 similar to H. pylori 26695 gene HP1025 NP_223119.1 similar to H. pylori 26695 gene HP1024 NP_223120.1 similar to H. pylori 26695 gene HP1023 NP_223121.1 similar to H. pylori 26695 gene HP1022 NP_223122.1 similar to H. pylori 26695 gene HP1021 NP_223123.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations NP_223124.1 similar to H. pylori 26695 gene HP1019 NP_223125.1 similar to H. pylori 26695 gene HP1017 NP_223126.1 similar to H. pylori 26695 gene HP1016 NP_223127.1 similar to H. pylori 26695 gene HP1015 NP_223128.1 Acts on the hydroxyl group at position 7 of the steroid frame NP_223129.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_223130.1 similar to H. pylori 26695 gene HP1012 NP_223131.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_223132.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate NP_223134.1 similar to H. pylori 26695 gene HP0463 NP_223135.1 similar to H. pylori 26695 gene HP0465 NP_223136.1 similar to H. pylori 26695 gene HP0466 NP_223137.1 similar to H. pylori 26695 gene HP0467 NP_223138.1 similar to H. pylori 26695 gene HP0468 NP_223139.1 similar to H. pylori 26695 gene HP0469 NP_223140.1 similar to H. pylori 26695 gene HP0470 NP_223141.1 similar to H. pylori 26695 gene HP0471 NP_223142.1 similar to H. pylori 26695 gene HP0472 NP_223143.1 similar to H. pylori 26695 gene HP0473 NP_223144.1 similar to H. pylori 26695 gene HP0474 NP_223145.1 similar to H. pylori 26695 gene HP0475 NP_223146.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_223147.1 similar to H. pylori 26695 gene HP0477 NP_223148.1 similar to H. pylori 26695 gene HP0478 NP_223149.1 similar to H. pylori 26695 gene HP0479 NP_223150.1 similar to H. pylori 26695 gene HP0480 NP_223151.1 similar to H. pylori 26695 gene HP0481 NP_223152.1 similar to H. pylori 26695 gene HP0482 NP_223153.1 similar to H. pylori 26695 gene HP0483 NP_223154.1 similar to H. pylori 26695 gene HP0484 NP_223155.1 similar to H. pylori 26695 gene HP0485 NP_223156.1 similar to H. pylori 26695 gene HP0486 NP_223157.1 similar to H. pylori 26695 gene HP0487 NP_223158.1 similar to H. pylori 26695 gene HP0488 NP_223159.1 similar to H. pylori 26695 gene HP0489 NP_223160.1 similar to H. pylori 26695 gene HP0490 NP_223161.1 required for 70S ribosome assembly NP_223162.1 similar to H. pylori 26695 gene HP0492 NP_223163.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_223164.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_223165.1 similar to H. pylori 26695 gene HP0495 NP_223166.1 similar to H. pylori 26695 gene HP0496 NP_223167.1 similar to H. pylori 26695 gene HP0497 NP_223168.1 similar to H. pylori 26695 gene HP0498 NP_223169.1 similar to H. pylori 26695 gene HP0499 NP_223170.1 binds the polymerase to DNA and acts as a sliding clamp NP_223171.1 negatively supercoils closed circular double-stranded DNA NP_223172.1 similar to H. pylori 26695 gene HP0502 and HP0503 NP_223173.1 similar to H. pylori 26695 gene HP0504 and HP0505 NP_223174.1 similar to H. pylori 26695 gene HP0506 NP_223175.1 similar to H. pylori 26695 gene HP0507 NP_223176.1 similar to H. pylori 26695 gene HP0508 NP_223177.1 similar to H. pylori 26695 gene HP0509 NP_223178.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_223179.1 similar to H. pylori 26695 gene HP0512 NP_223180.1 similar to H. pylori 26695 gene HP0513 NP_223181.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_223182.1 heat shock protein involved in degradation of misfolded proteins NP_223183.1 heat shock protein involved in degradation of misfolded proteins NP_223184.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_223185.1 similar to H. pylori 26695 gene HP0518 NP_223186.1 similar to H. pylori 26695 gene HP0519 NP_223187.1 similar to H. pylori 26695 gene HP0520 NP_223188.1 similar to H. pylori 26695 gene HP0521 NP_223189.1 similar to H. pylori 26695 gene HP0522 NP_223190.1 similar to H. pylori 26695 gene HP0523 NP_223191.1 similar to H. pylori 26695 gene HP0524 NP_223192.1 similar to H. pylori 26695 gene HP0525 NP_223193.1 similar to H. pylori 26695 gene HP0526 NP_223194.1 similar to H. pylori 26695 gene HP0527 NP_223195.1 similar to H. pylori 26695 gene HP0528 NP_223196.1 similar to H. pylori 26695 gene HP0529 NP_223197.1 similar to H. pylori 26695 gene HP0530 NP_223198.1 similar to H. pylori 26695 gene HP0531 NP_223199.1 similar to H. pylori 26695 gene HP0532 NP_223200.1 similar to H. pylori 26695 gene HP0534 NP_223201.1 similar to H. pylori 26695 gene HP0535 NP_223202.1 similar to H. pylori 26695 gene HP0536 NP_223203.1 similar to H. pylori 26695 gene HP0537 NP_223204.1 similar to H. pylori 26695 gene HP0538 NP_223205.1 similar to H. pylori 26695 gene HP0539 NP_223206.1 similar to H. pylori 26695 gene HP0540 NP_223207.1 similar to H. pylori 26695 gene HP0541 NP_223208.1 similar to H. pylori 26695 gene HP0542 NP_223209.1 similar to H. pylori 26695 gene HP0543 NP_223210.1 similar to H. pylori 26695 gene HP0544 NP_223211.1 similar to H. pylori 26695 gene HP0545 NP_223212.1 similar to H. pylori 26695 gene HP0546 NP_223213.1 similar to H. pylori 26695 gene HP0547 NP_223214.1 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_223215.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_223216.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_223217.1 similar to H. pylori 26695 gene HP0552 NP_223218.1 similar to H. pylori 26695 gene HP0553 NP_223219.1 similar to H. pylori 26695 gene HP0554 NP_223220.1 similar to H. pylori 26695 gene HP0555 NP_223221.1 similar to H. pylori 26695 gene HP0556 NP_223222.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_223223.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_223224.1 carries the fatty acid chain in fatty acid biosynthesis NP_223226.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_223227.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_223228.1 similar to H. pylori 26695 gene HP0563 NP_223229.1 similar to H. pylori 26695 gene HP0564 NP_223230.1 similar to H. pylori 26695 gene HP0565 NP_223231.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_223232.1 similar to H. pylori 26695 gene HP0567 NP_223233.1 similar to H. pylori 26695 gene HP0568 NP_223234.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_223235.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_223236.1 similar to H. pylori 26695 gene HP0571 NP_223237.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_223238.1 similar to H. pylori 26695 gene HP0573 NP_223239.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity NP_223240.1 similar to H. pylori 26695 gene HP0575 NP_223241.1 similar to H. pylori 26695 gene HP0576 NP_223242.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_223243.1 similar to H. pylori 26695 gene HP0578 NP_223244.1 similar to H. pylori 26695 gene HP0579 NP_223245.1 similar to H. pylori 26695 gene HP0580 NP_223246.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_223247.1 similar to H. pylori 26695 gene HP0582 NP_223248.1 similar to H. pylori 26695 gene HP0583 NP_223249.1 One of three proteins involved in switching the direction of the flagellar rotation NP_223250.1 similar to H. pylori 26695 gene HP0585 NP_223252.1 similar to H. pylori 26695 gene HP0586 NP_223253.1 similar to H. pylori 26695 gene HP0587 NP_223254.1 similar to H. pylori 26695 gene HP0588 NP_223255.1 Couples the complete acetyl-CoA oxidation to aromatic ring reduction by the use of the low-potential electron shuttle ferredoxin NP_223256.1 Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin NP_223257.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates NP_223259.1 similar to H. pylori 26695 gene HP0594 NP_223260.1 similar to H. pylori 26695 gene HP0595 NP_223261.1 Tip-alpha; forms a dimer; found in culture supernatant; induces TNF-alpha and NF-kappa-B in cell cultures of mouse cells NP_223262.1 similar to H. pylori 26695 gene HP0597 NP_223263.1 similar to H. pylori 26695 gene HP0598 NP_223264.1 similar to H. pylori 26695 gene HP0599 NP_223265.1 similar to H. pylori 26695 gene HP0600 NP_223266.1 FlaA; structural flagella protein; in Helicobacter flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions NP_223267.1 similar to H. pylori 26695 gene HP0602 NP_223268.1 similar to H. pylori 26695 gene HP0603 NP_223269.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_223270.1 similar to H. pylori 26695 gene HP0605 NP_223271.1 similar to H. pylori 26695 gene HP0606 NP_223272.1 similar to H. pylori 26695 gene HP0607 NP_223273.1 similar to H. pylori 26695 gene HP0608 NP_223274.1 similar to H. pylori 26695 gene HP0609 and HP0610 NP_223275.1 similar to H. pylori 26695 gene HP0614 NP_223276.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_223277.1 similar to H. pylori 26695 gene HP0616 NP_223278.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_223279.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_223281.1 similar to TIGR HP0619; expression of this protein is predicted to be regulated by slipped-strand repair at the (C) polynucleotide repeat; length of the repeat has been artificially adjusted (removal of one nucleotide) to give the full length protein NP_223282.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_223283.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange NP_223284.1 similar to H. pylori 26695 gene HP0622 NP_223285.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_223286.1 similar to H. pylori 26695 gene HP0624 NP_223287.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis NP_223288.1 similar to H. pylori 26695 gene HP0626 NP_223289.1 similar to H. pylori 26695 gene HP0627 and HP0628 NP_223290.1 similar to H. pylori 26695 gene HP0629 NP_223291.1 similar to H. pylori 26695 gene HP0630 NP_223292.1 similar to H. pylori 26695 gene HP0631 NP_223293.1 similar to H. pylori 26695 gene HP0632 NP_223294.1 similar to H. pylori 26695 gene HP0633 NP_223295.1 similar to H. pylori 26695 gene HP0634 NP_223296.1 similar to H. pylori 26695 gene HP0635 NP_223297.1 similar to H. pylori 26695 gene HP0636 NP_223298.1 similar to H. pylori 26695 gene HP0637 NP_223299.1 similar to H. pylori 26695 gene HP0638 NP_223300.1 similar to H. pylori 26695 gene HP0639 NP_223301.1 similar to H. pylori 26695 gene HP0640 NP_223302.1 similar to H. pylori 26695 gene HP0641 NP_223304.1 similar to H. pylori 26695 gene HP0642 NP_223306.1 charges one glutamine molecule and pairs it with tRNA(Gln) NP_223307.1 similar to H. pylori 26695 gene HP0644 NP_223308.1 similar to H. pylori 26695 gene HP0645 NP_223309.1 similar to H. pylori 26695 gene HP0646 NP_223310.1 similar to H. pylori 26695 gene HP0647 NP_223311.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_223312.1 catalyzes the formation of fumarate from aspartate NP_223313.1 similar to H. pylori 26695 gene HP0650 NP_223314.1 similar to H. pylori 26695 gene HP0651 NP_223315.1 similar to H. pylori 26695 gene HP0652 NP_223316.1 similar to H. pylori 26695 gene HP0653 NP_223317.1 similar to H. pylori 26695 gene HP0654 NP_223318.1 similar to H. pylori 26695 gene HP0655 NP_223319.1 similar to H. pylori 26695 gene HP0656 NP_223320.1 similar to H. pylori 26695 gene HP0657 NP_223321.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_223322.1 similar to H. pylori 26695 gene HP0659 NP_223323.1 similar to H. pylori 26695 gene HP0660 NP_223324.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_223325.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_223326.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_223327.1 similar to H. pylori 26695 gene HP0664 NP_223328.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_223329.1 similar to H. pylori 26695 gene HP0666 NP_223330.1 similar to H. pylori 26695 gene HP0667 and HP0668 NP_223331.1 similar to H. pylori 26695 gene HP0669 NP_223332.1 similar to H. pylori 26695 gene HP0671 NP_223333.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_223335.1 similar to H. pylori 26695 gene HP0675 NP_223336.1 similar to H. pylori 26695 gene HP0676 NP_223337.1 similar to H. pylori 26695 gene HP0677 NP_223338.1 similar to H. pylori 26695 gene HP0679 NP_223339.1 Catalyzes the rate-limiting step in dNTP synthesis NP_223340.1 similar to H. pylori 26695 gene HP0681 NP_223341.1 similar to H. pylori 26695 gene HP0682 NP_223342.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_223343.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus NP_223344.1 similar to H. pylori 26695 gene HP0686 NP_223345.1 similar to H. pylori 26695 gene HP0687 NP_223346.1 similar to H. pylori 26695 gene HP0688 and HP0689 NP_223349.1 similar to H. pylori 26695 gene HP0697 NP_223350.1 similar to H. pylori 26695 gene HP0696 NP_223351.1 similar to H. pylori 26695 gene HP0695 NP_223352.1 similar to H. pylori 26695 gene HP0694 NP_223353.1 similar to H. pylori 26695 gene HP0693 NP_223354.1 similar to H. pylori 26695 gene HP0692 NP_223355.1 similar to H. pylori 26695 gene HP0691 NP_223356.1 similar to H. pylori 26695 gene HP0690 NP_223357.1 similar to H. pylori 26695 gene HP0699 NP_223358.1 similar to H. pylori 26695 gene HP0700 NP_223359.1 negatively supercoils closed circular double-stranded DNA NP_223360.1 similar to H. pylori 26695 gene HP0702 NP_223361.1 similar to H. pylori 26695 gene HP0703 NP_223362.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_223363.1 similar to H. pylori 26695 gene HP0706 NP_223364.1 similar to H. pylori 26695 gene HP0707 NP_223365.1 similar to H. pylori 26695 gene HP0708 NP_223366.1 similar to H. pylori 26695 gene HP0709 NP_223367.1 similar to H. pylori 26695 gene HP0710 NP_223368.1 similar to H. pylori 26695 gene HP0711 NP_223369.1 similar to H. pylori 26695 gene HP0712 and HP0713 NP_223370.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen NP_223371.1 similar to H. pylori 26695 gene HP0715 NP_223372.1 similar to H. pylori 26695 gene HP0716 NP_223373.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_223374.1 similar to H. pylori 26695 gene HP0718 NP_223375.1 similar to H. pylori 26695 gene HP0719 and HP0720 NP_223376.1 similar to H. pylori 26695 gene HP0721 NP_223377.1 similar to TIGR HP0722; expression of this protein is predicted to be regulated by slipped-strand repair at the (CT) dinucleotide repeat; length of the repeat has been artificially adjusted (addition of one dinucleotide) to give the full length protein NP_223378.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB NP_223379.1 similar to H. pylori 26695 gene HP0723 NP_223380.1 similar to TIGR HP0725; expression of this protein is predicted to be regulated by slipped-strand repair at the (CT) dinucleotide repeat; length of the repeat has been artificially adjusted (addition of one dinucleotide) to give the full length protein NP_223381.1 similar to H. pylori 26695 gene HP0726 NP_223382.1 similar to H. pylori 26695 gene HP0727 NP_223383.1 similar to H. pylori 26695 gene HP0728 NP_223384.1 similar to H. pylori 26695 gene HP0729 NP_223385.1 similar to H. pylori 26695 gene HP0730 NP_223386.1 similar to H. pylori 26695 gene HP0731 NP_223387.1 similar to H. pylori 26695 gene HP0732 NP_223388.1 similar to H. pylori 26695 gene HP0733 NP_223389.1 similar to H. pylori 26695 gene HP0734 NP_223390.1 similar to H. pylori 26695 gene HP0735 NP_223391.1 similar to H. pylori 26695 gene HP0736 NP_223392.1 similar to H. pylori 26695 gene HP0737 NP_223393.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_223394.1 similar to H. pylori 26695 gene HP0739 NP_223395.1 similar to H. pylori 26695 gene HP0740 NP_223396.1 similar to H. pylori 26695 gene HP0741 NP_223397.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_223398.1 similar to H. pylori 26695 gene HP0743 NP_223399.1 similar to TIGR HP0744; expression of this protein is predicted to be regulated by slipped-strand repair at the (AG) dinucleotide repeat; length of the repeat has been artificially adjusted (addition of one dinucleotide) to give the full length protein NP_223400.1 similar to H. pylori 26695 gene HP0745 NP_223401.1 similar to H. pylori 26695 gene HP0746 NP_223402.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_223403.1 similar to H. pylori 26695 gene HP0748 NP_223404.1 similar to H. pylori 26695 gene HP0749 NP_223405.1 similar to H. pylori 26695 gene HP0750 NP_223406.1 possibly involved in flagella export NP_223407.1 involved in flagellin assembly NP_223408.1 flagellin specific chaperone NP_223409.1 similar to H. pylori 26695 gene HP0754 NP_223410.1 similar to H. pylori 26695 gene HP0755 NP_223411.1 similar to H. pylori 26695 gene HP0756 NP_223412.1 similar to H. pylori 26695 gene HP0757 NP_223413.1 similar to H. pylori 26695 gene HP0758 NP_223414.1 similar to H. pylori 26695 gene HP0759 NP_223415.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_223416.1 similar to H. pylori 26695 gene HP0761 NP_223417.1 similar to H. pylori 26695 gene HP0762 NP_223418.1 similar to H. pylori 26695 gene HP0763 NP_223419.1 similar to H. pylori 26695 gene HP0764 NP_223420.1 similar to H. pylori 26695 gene HP0764 NP_223421.1 similar to H. pylori 26695 gene HP0765 NP_223422.1 similar to H. pylori 26695 gene HP0766 NP_223423.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z NP_223424.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis NP_223425.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export NP_223426.1 similar to H. pylori 26695 gene HP0771 NP_223427.1 similar to H. pylori 26695 gene HP0772 NP_223428.1 similar to H. pylori 26695 gene HP0773 NP_223429.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_223430.1 similar to H. pylori 26695 gene HP0775 NP_223431.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_223432.1 Catalyzes the phosphorylation of UMP to UDP NP_223433.1 similar to H. pylori 26695 gene HP0778 NP_223434.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate NP_223435.1 similar to H. pylori 26695 gene HP0780 NP_223436.1 similar to H. pylori 26695 gene HP0781 NP_223437.1 similar to H. pylori 26695 gene HP0782 NP_223438.1 similar to H. pylori 26695 gene HP0783 NP_223439.1 similar to H. pylori 26695 gene HP0784 NP_223440.1 participates with LolB in the incorporation of lipoprotein into the outer membrane NP_223441.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_223442.1 similar to H. pylori 26695 gene HP0787 NP_223443.1 similar to H. pylori 26695 gene HP0788 NP_223445.1 similar to H. pylori 26695 gene HP0791 NP_223446.1 similar to H. pylori 26695 gene HP0792 NP_223447.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_223448.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_223449.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_223450.1 similar to H. pylori 26695 gene HP0796 NP_223451.1 similar to H. pylori 26695 gene HP0797 NP_223452.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis NP_223453.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis NP_223454.1 similar to H. pylori 26695 gene HP0800 NP_223455.1 similar to H. pylori 26695 gene HP0801 NP_223456.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate NP_223457.1 similar to H. pylori 26695 gene HP0803 NP_223458.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate NP_223459.1 similar to H. pylori 26695 gene HP0805 NP_223460.1 similar to H. pylori 26695 gene HP0806 NP_223461.1 similar to H. pylori 26695 gene HP0807 NP_223462.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_223463.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring NP_223464.1 similar to H. pylori 26695 gene HP0810 NP_223465.1 similar to H. pylori 26695 gene HP0811 NP_223466.1 similar to H. pylori 26695 gene HP0812 NP_223467.1 similar to H. pylori 26695 gene HP0813 NP_223468.1 similar to H. pylori 26695 gene HP0814 NP_223469.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine NP_223470.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine NP_223471.1 similar to H. pylori 26695 gene HP0817 NP_223472.1 similar to H. pylori 26695 gene HP0818 NP_223475.1 similar to H. pylori 26695 gene HP0818 NP_223476.1 similar to H. pylori 26695 gene HP0819 NP_223477.1 similar to H. pylori 26695 gene HP0820 NP_223478.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_223479.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_223480.1 similar to H. pylori 26695 gene HP0823 NP_223481.1 similar to H. pylori 26695 gene HP0824 NP_223482.1 similar to H. pylori 26695 gene HP0825 NP_223483.1 similar to H. pylori 26695 gene HP0826 NP_223484.1 similar to H. pylori 26695 gene HP0827 NP_223485.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_223486.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_223487.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_223488.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_223489.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine NP_223490.1 similar to H. pylori 26695 gene HP0833 NP_223491.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_223492.1 similar to H. pylori 26695 gene HP0835 NP_223493.1 similar to H. pylori 26695 gene HP0836 and HP0837 NP_223494.1 similar to H. pylori 26695 gene HP0838 NP_223495.1 similar to H. pylori 26695 gene HP0839 NP_223496.1 similar to H. pylori 26695 gene HP0840 NP_223497.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine NP_223498.1 similar to H. pylori 26695 gene HP0842 NP_223499.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_223500.1 similar to H. pylori 26695 gene HP0844 NP_223501.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_223502.1 similar to H. pylori 26695 gene HP0846 NP_223503.1 similar to H. pylori 26695 gene HP0848 and HP0849 NP_223504.1 similar to H. pylori 26695 gene HP0850 NP_223505.1 similar to H. pylori 26695 gene HP0851 NP_223506.1 similar to H. pylori 26695 gene HP0852 NP_223507.1 similar to H. pylori 26695 gene HP0853 NP_223508.1 similar to H. pylori 26695 gene HP0854 NP_223509.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate NP_223510.1 similar to H. pylori 26695 gene HP0858 NP_223511.1 similar to H. pylori 26695 gene HP0859 NP_223512.1 similar to H. pylori 26695 gene HP0860 NP_223513.1 similar to H. pylori 26695 gene HP0861 NP_223514.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP NP_223515.1 similar to H. pylori 26695 gene HP0863 NP_223516.1 similar to H. pylori 26695 gene HP0864 NP_223517.1 catalyzes the formation of dUMP from dUTP NP_223518.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_223519.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM NP_223520.1 similar to H. pylori 26695 gene HP0868 NP_223521.1 plays a role in hydrogenase nickel cofactor insertion NP_223522.1 the hook connects flagellar basal body to the flagellar filament NP_223523.1 similar to H. pylori 26695 gene HP0871 NP_223524.1 similar to H. pylori 26695 gene HP0872 NP_223525.1 similar to H. pylori 26695 gene HP0873 NP_223526.1 similar to H. pylori 26695 gene HP0874 NP_223527.1 similar to H. pylori 26695 gene HP0875 NP_223528.1 similar to H. pylori 26695 gene HP0876 NP_223529.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_223530.1 similar to H. pylori 26695 gene HP0878 and HP0879 NP_223533.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_223534.1 similar to H. pylori 26695 gene HP0884 NP_223535.1 similar to H. pylori 26695 gene HP0885 NP_223536.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_223537.1 similar to H. pylori 26695 gene HP0887 NP_223539.1 similar to H. pylori 26695 gene HP0888 NP_223540.1 similar to H. pylori 26695 gene HP0889 NP_223541.1 similar to H. pylori 26695 gene HP0890 NP_223542.1 similar to H. pylori 26695 gene HP0891 NP_223549.1 similar to H. pylori 26695 gene HP0892 NP_223550.1 similar to H. pylori 26695 gene HP0893 NP_223551.1 similar to H. pylori 26695 gene HP1243 NP_223553.1 similar to H. pylori 26695 gene HP0898 NP_223554.1 similar to H. pylori 26695 gene HP0899 NP_223555.1 similar to H. pylori 26695 gene HP0900 NP_223556.1 similar to H. pylori 26695 gene HP0901 NP_223557.1 similar to H. pylori 26695 gene HP0902 NP_223558.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_223559.1 similar to H. pylori 26695 gene HP0904 and HP0905 NP_223560.1 similar to H. pylori 26695 gene HP0906 NP_223561.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod NP_223562.1 the hook connects flagellar basal body to the flagellar filament NP_223563.1 similar to H. pylori 26695 gene HP0909 NP_223564.1 similar to H. pylori 26695 gene HP0910 NP_223565.1 similar to H. pylori 26695 gene HP0911 NP_223566.1 similar to H. pylori 26695 gene HP0912 NP_223567.1 similar to H. pylori 26695 gene HP0913 NP_223568.1 similar to H. pylori 26695 gene HP0914 NP_223569.1 similar to H. pylori 26695 gene HP0915 and HP0916 NP_223570.1 similar to H. pylori 26695 gene HP0918 NP_223571.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_223572.1 similar to H. pylori 26695 gene HP0920 NP_223573.1 similar to H. pylori 26695 gene HP0921 NP_223574.1 similar to H. pylori 26695 gene HP0922 NP_223575.1 similar to H. pylori 26695 gene HP0923 NP_223576.1 similar to H. pylori 26695 gene HP0924 NP_223577.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_223578.1 catalyzes the modification of U13 in tRNA(Glu) NP_223579.1 metalloprotease NP_223580.1 similar to H. pylori 26695 gene HP0928 NP_223581.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer NP_223582.1 similar to H. pylori 26695 gene HP0929 NP_223583.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate NP_223584.1 similar to H. pylori 26695 gene HP0931 and HP0932 NP_223585.1 similar to H. pylori 26695 gene HP0933 NP_223586.1 similar to H. pylori 26695 gene HP0934 NP_223587.1 similar to H. pylori 26695 gene HP0935 NP_223589.1 similar to H. pylori 26695 gene HP0936 NP_223590.1 similar to H. pylori 26695 gene HP0937 NP_223591.1 similar to H. pylori 26695 gene HP0938 NP_223592.1 similar to H. pylori 26695 gene HP0939 NP_223593.1 similar to H. pylori 26695 gene HP0940 NP_223594.1 similar to H. pylori 26695 gene HP0941 NP_223595.1 similar to H. pylori 26695 gene HP0942 NP_223596.1 similar to H. pylori 26695 gene HP0943 NP_223597.1 similar to H. pylori 26695 gene HP0944 NP_223598.1 similar to H. pylori 26695 gene HP0946 NP_223599.1 similar to H. pylori 26695 gene HP0947 NP_223600.1 similar to H. pylori 26695 gene HP0948 NP_223601.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_223602.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_223603.1 similar to H. pylori 26695 gene HP0951 NP_223604.1 similar to H. pylori 26695 gene HP0952 NP_223605.1 similar to H. pylori 26695 gene HP0953 NP_223606.1 similar to H. pylori 26695 gene HP0954 NP_223607.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_223608.1 similar to H. pylori 26695 gene HP0956 NP_223609.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A NP_223610.1 similar to H. pylori 26695 gene HP0958 NP_223611.1 similar to H. pylori 26695 gene HP0959 NP_223612.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_223613.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_223615.1 similar to H. pylori 26695 gene HP0963 NP_223616.1 similar to H. pylori 26695 gene HP0964 NP_223617.1 similar to H. pylori 26695 gene HP0964 and HP0965 NP_223618.1 similar to H. pylori 26695 gene HP0966 NP_223619.1 similar to H. pylori 26695 gene HP0966 NP_223620.1 similar to H. pylori 26695 gene HP0968 NP_223621.1 similar to H. pylori 26695 gene HP0969 NP_223622.1 similar to H. pylori 26695 gene HP0970 NP_223623.1 similar to H. pylori 26695 gene HP0971 NP_223624.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_223625.1 similar to H. pylori 26695 gene HP0973 NP_223626.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_223627.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_223628.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate NP_223629.1 similar to H. pylori 26695 gene HP0977 NP_223630.1 similar to H. pylori 26695 gene HP0978 NP_223631.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_223633.1 similar to H. pylori 26695 gene HP0983 NP_223655.1 similar to H. pylori 26695 gene HP0990 NP_223656.1 similar to H. pylori 26695 gene HP0991 NP_223658.1 similar to H. pylori 26695 gene HP0995 NP_223659.1 similar to H. pylori 26695 gene HP0996 NP_223669.1 similar to H. pylori 26695 gene HP0427 NP_223679.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis NP_223680.1 similar to H. pylori 26695 gene HP0421 NP_223681.1 similar to H. pylori 26695 gene HP0420 NP_223682.1 similar to H. pylori 26695 gene HP0419 NP_223683.1 similar to H. pylori 26695 gene HP0418 NP_223684.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_223685.1 similar to H. pylori 26695 gene HP0416 NP_223686.1 similar to H. pylori 26695 gene HP0415 NP_223687.1 similar to H. pylori 26695 gene HP0412 NP_223688.1 similar to H. pylori 26695 gene HP0410 NP_223689.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_223690.1 similar to H. pylori 26695 gene HP0408 NP_223691.1 similar to H. pylori 26695 gene HP0407 NP_223692.1 similar to H. pylori 26695 gene HP0406 NP_223693.1 similar to H. pylori 26695 gene HP0405 NP_223694.1 similar to H. pylori 26695 gene HP0404 NP_223695.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_223696.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_223697.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_223698.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_223699.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_223700.1 similar to H. pylori 26695 gene HP0398 NP_223701.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_223702.1 similar to H. pylori 26695 gene HP0396 NP_223703.1 similar to H. pylori 26695 gene HP0395 NP_223704.1 similar to H. pylori 26695 gene HP0394 NP_223705.1 similar to H. pylori 26695 gene HP0393 NP_223706.1 similar to H. pylori 26695 gene HP0392 NP_223707.1 similar to H. pylori 26695 gene HP0391 NP_223708.1 similar to H. pylori 26695 gene HP0390 NP_223709.1 similar to H. pylori 26695 gene HP0389 NP_223710.1 similar to H. pylori 26695 gene HP0388 NP_223711.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_223712.1 similar to H. pylori 26695 gene HP0386 NP_223713.1 similar to H. pylori 26695 gene HP0385 NP_223714.1 similar to H. pylori 26695 gene HP0384 NP_223715.1 similar to H. pylori 26695 gene HP0383 NP_223716.1 similar to H. pylori 26695 gene HP0382 NP_223717.1 similar to H. pylori 26695 gene HP0381 NP_223718.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer NP_223719.1 similar to TIGR HP0379; expression of this protein is predicted to be regulated by slipped-strand repair at both the (C) and the (A) polynucleotide repeats; length of the (A) polynucleotide repeat has been artificially adjusted (addition of one nucleotide) to give the full length protein NP_223720.1 similar to H. pylori 26695 gene HP0378 NP_223721.1 similar to H. pylori 26695 gene HP0377 NP_223722.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_223723.1 similar to H. pylori 26695 gene HP0375 NP_223724.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_223725.1 similar to H. pylori 26695 gene HP0373 NP_223726.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis NP_223727.1 similar to H. pylori 26695 gene HP0371 NP_223728.1 biotin carboxylase; biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA; catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_223729.1 similar to H. pylori 26695 gene HP0369 NP_223730.1 similar to H. pylori 26695 gene HP0368 NP_223731.1 similar to H. pylori 26695 gene HP0367 NP_223732.1 similar to H. pylori 26695 gene HP0366 NP_223733.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_223734.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins NP_223735.1 similar to H. pylori 26695 gene HP0362 NP_223736.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_223737.1 similar to H. pylori 26695 gene HP0360 NP_223739.1 similar to H. pylori 26695 gene HP0358 NP_223740.1 similar to H. pylori 26695 gene HP0357 NP_223741.1 similar to H. pylori 26695 gene HP1098 NP_223742.1 similar to H. pylori 26695 gene HP1099 NP_223743.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate NP_223744.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_223745.1 similar to H. pylori 26695 gene HP1102 NP_223746.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate NP_223747.1 similar to H. pylori 26695 gene HP1104 NP_223748.1 similar to H. pylori 26695 gene HP1105 NP_223750.1 similar to H. pylori 26695 gene HP1106 NP_223751.1 similar to H. pylori 26695 gene HP1107 NP_223752.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates NP_223753.1 similar to H. pylori 26695 gene HP1109 NP_223754.1 Couples the complete acetyl-CoA oxidation to aromatic ring reduction by the use of the low-potential electron shuttle ferredoxin NP_223755.1 Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin NP_223756.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_223757.1 similar to H. pylori 26695 gene HP1113 NP_223758.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_223759.1 similar to H. pylori 26695 gene HP1115 NP_223761.1 similar to H. pylori 26695 gene HP1116 NP_223762.1 similar to H. pylori 26695 gene HP1117 NP_223763.1 similar to H. pylori 26695 gene HP1118 NP_223764.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook NP_223765.1 similar to H. pylori 26695 gene HP1120 NP_223767.1 similar to H. pylori 26695 gene HP1121 NP_223768.1 similar to H. pylori 26695 gene HP1122 NP_223769.1 similar to H. pylori 26695 gene HP1123 NP_223770.1 similar to H. pylori 26695 gene HP1124 NP_223771.1 similar to H. pylori 26695 gene HP1125 NP_223772.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA NP_223773.1 similar to H. pylori 26695 gene HP1127 and HP1128 NP_223774.1 similar to H. pylori 26695 gene HP1129 NP_223775.1 similar to H. pylori 26695 gene HP1130 NP_223776.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_223777.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_223778.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_223779.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_223780.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_223781.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_223782.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. NP_223783.1 similar to H. pylori 26695 gene HP1138 NP_223784.1 similar to H. pylori 26695 gene HP1139 NP_223785.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon NP_223786.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_223787.1 similar to H. pylori 26695 gene HP1142 NP_223788.1 similar to H. pylori 26695 gene HP1143 NP_223789.1 similar to H. pylori 26695 gene HP1144 NP_223790.1 similar to H. pylori 26695 gene HP1145 and HP1146 NP_223791.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_223792.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_223793.1 Essential for efficient processing of 16S rRNA NP_223794.1 similar to H. pylori 26695 gene HP1150 NP_223795.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_223796.1 similar to H. pylori 26695 gene HP1152 NP_223797.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_223798.1 binds to flagellin and appears to stabilize flagellin during flagella assembly NP_223799.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_223800.1 similar to H. pylori 26695 gene HP1156 NP_223801.1 similar to H. pylori 26695 gene HP1157 NP_223802.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate NP_223803.1 similar to H. pylori 26695 gene HP1159 NP_223804.1 similar to H. pylori 26695 gene HP1160 NP_223805.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_223806.1 similar to H. pylori 26695 gene HP1162 NP_223807.1 similar to H. pylori 26695 gene HP1163 NP_223808.1 similar to H. pylori 26695 gene HP1164 NP_223809.1 similar to H. pylori 26695 gene HP1165 NP_223810.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_223811.1 similar to H. pylori 26695 gene HP1167 NP_223812.1 similar to H. pylori 26695 gene HP1168 NP_223813.1 similar to H. pylori 26695 gene HP1169 NP_223814.1 similar to H. pylori 26695 gene HP1170 NP_223815.1 similar to H. pylori 26695 gene HP1171 NP_223816.1 similar to H. pylori 26695 gene HP1172 NP_223817.1 similar to H. pylori 26695 gene HP1173 NP_223818.1 similar to H. pylori 26695 gene HP1174 NP_223819.1 similar to H. pylori 26695 gene HP1175 NP_223820.1 similar to H. pylori 26695 gene HP1177 NP_223821.1 similar to H. pylori 26695 gene HP1178 NP_223822.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_223823.1 similar to H. pylori 26695 gene HP1180 NP_223824.1 similar to H. pylori 26695 gene HP1181 NP_223825.1 similar to H. pylori 26695 gene HP1182 NP_223826.1 similar to H. pylori 26695 gene HP1183 NP_223827.1 similar to H. pylori 26695 gene HP1184 NP_223828.1 similar to H. pylori 26695 gene HP1185 NP_223829.1 similar to H. pylori 26695 gene HP1186 NP_223830.1 similar to H. pylori 26695 gene HP1187 NP_223831.1 similar to H. pylori 26695 gene HP1189 NP_223832.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_223833.1 similar to H. pylori 26695 gene HP1191 NP_223834.1 similar to H. pylori 26695 gene HP1192 NP_223835.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_223836.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_223837.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_223838.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; fusion of rpoB and rpoC; beta and beta' subunits are part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_223839.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_223840.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_223841.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_223842.1 binds directly to 23S ribosomal RNA NP_223843.1 Modulates Rho-dependent transcription termination NP_223844.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_223845.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_223846.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_223847.1 similar to H. pylori 26695 gene HP1206 NP_223848.1 similar to H. pylori 26695 gene HP1207 NP_223849.1 similar to H. pylori 26695 gene HP1208 NP_223851.1 similar to H. pylori 26695 gene HP1210 NP_223853.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_223854.1 similar to H. pylori 26695 gene HP1213 NP_223855.1 similar to H. pylori 26695 gene HP1214 NP_223856.1 similar to H. pylori 26695 gene HP1215 and HP1216 NP_223857.1 similar to H. pylori 26695 gene HP1217 NP_223858.1 similar to H. pylori 26695 gene HP1218 NP_223859.1 similar to H. pylori 26695 gene HP1220 NP_223860.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_223861.1 similar to H. pylori 26695 gene HP1222 NP_223862.1 similar to H. pylori 26695 gene HP1223 NP_223863.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis NP_223864.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_223865.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_223866.1 similar to H. pylori 26695 gene HP1227 NP_223867.1 hydrolyzes diadenosine polyphosphate NP_223868.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. NP_223869.1 similar to H. pylori 26695 gene HP1230 NP_223870.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_223871.1 similar to H. pylori 26695 gene HP1232 NP_223872.1 similar to H. pylori 26695 gene HP1233 NP_223873.1 similar to H. pylori 26695 gene HP1234 NP_223874.1 similar to H. pylori 26695 gene HP1235 NP_223875.1 similar to H. pylori 26695 gene HP1236 NP_223876.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_223877.1 formamide amidohydrolase; catalyzes the hydrolysis of formamide to formate NP_223879.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_223880.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_223881.1 similar to H. pylori 26695 gene HP1242 NP_223882.1 similar to H. pylori 26695 gene HP0896 NP_223883.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_223884.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_223885.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_223886.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_223887.1 similar to H. pylori 26695 gene HP1248 NP_223888.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate NP_223889.1 similar to H. pylori 26695 gene HP1250 NP_223890.1 similar to H. pylori 26695 gene HP1251 NP_223891.1 similar to H. pylori 26695 gene HP1252 NP_223892.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_223893.1 similar to H. pylori 26695 gene HP1254 NP_223894.1 similar to H. pylori 26695 gene HP1255 NP_223895.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_223896.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_223897.1 similar to H. pylori 26695 gene HP1258 NP_223898.1 similar to H. pylori 26695 gene HP1259 NP_223899.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_223900.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen NP_223901.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_223902.1 Catalyzes the transfer of electrons from NADH to quinone NP_223903.1 similar to H. pylori 26695 gene HP1264 NP_223904.1 similar to H. pylori 26695 gene HP1265 NP_223905.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_223906.1 Catalyzes the transfer of electrons from NADH to quinone NP_223907.1 Catalyzes the transfer of electrons from NADH to quinone NP_223908.1 Catalyzes the transfer of electrons from NADH to quinone NP_223909.1 Catalyzes the transfer of electrons from NADH to quinone NP_223910.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_223911.1 Catalyzes the transfer of electrons from NADH to quinone NP_223912.1 Catalyzes the transfer of electrons from NADH to quinone NP_223913.1 similar to H. pylori 26695 gene HP1274 NP_223914.1 similar to H. pylori 26695 gene HP1275 NP_223915.1 similar to H. pylori 26695 gene HP1276 NP_223916.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_223917.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_223918.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate NP_223919.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_223920.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity NP_223921.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_223922.1 similar to H. pylori 26695 gene HP1284 NP_223923.1 similar to H. pylori 26695 gene HP1285 NP_223924.1 similar to H. pylori 26695 gene HP1286 NP_223925.1 similar to H. pylori 26695 gene HP1287 NP_223926.1 similar to H. pylori 26695 gene HP1288 NP_223927.1 similar to H. pylori 26695 gene HP1289 NP_223928.1 similar to H. pylori 26695 gene HP1290 NP_223929.1 similar to H. pylori 26695 gene HP1291 NP_223930.1 is a component of the macrolide binding site in the peptidyl transferase center NP_223931.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_223932.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_223933.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_223934.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_223935.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_223936.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_223937.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn NP_223938.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_223939.1 late assembly protein NP_223940.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_223941.1 binds 5S rRNA along with protein L5 and L25 NP_223942.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_223943.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_223944.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif NP_223945.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_223946.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_223947.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_223948.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_223949.1 one of the stabilizing components for the large ribosomal subunit NP_223950.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_223951.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_223952.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_223953.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_223954.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_223955.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_223956.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_223957.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_223958.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_223959.1 similar to H. pylori 26695 gene HP1321 NP_223960.1 similar to H. pylori 26695 gene HP1322 NP_223961.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_223962.1 similar to H. pylori 26695 gene HP1324 NP_223963.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_223964.1 similar to H. pylori 26695 gene HP1326 NP_223965.1 similar to H. pylori 26695 gene HP1327 NP_223966.1 similar to H. pylori 26695 gene HP1328 NP_223967.1 similar to H. pylori 26695 gene HP1329 NP_223968.1 similar to H. pylori 26695 gene HP1330 NP_223969.1 similar to H. pylori 26695 gene HP1331 NP_223970.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_223971.1 similar to H. pylori 26695 gene HP1333 NP_223972.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_223973.1 similar to H. pylori 26695 gene HP1336 NP_223974.1 similar to H. pylori 26695 gene HP1337 NP_223975.1 Inhibits transcription at high concentrations of nickel NP_223976.1 similar to H. pylori 26695 gene HP1339 NP_223977.1 similar to H. pylori 26695 gene HP1340 NP_223978.1 similar to H. pylori 26695 gene HP1341 NP_223979.1 similar to H. pylori 26695 gene HP1342 NP_223980.1 similar to H. pylori 26695 gene HP1343 NP_223981.1 similar to H. pylori 26695 gene HP1344 NP_223982.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_223983.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate NP_223984.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_223985.1 similar to H. pylori 26695 gene HP1348 NP_223986.1 similar to H. pylori 26695 gene HP1349 NP_223987.1 similar to H. pylori 26695 gene HP1350 NP_223988.1 similar to H. pylori 26695 gene HP1351 NP_223989.1 similar to H. pylori 26695 gene HP1352 NP_223990.1 similar to TIGR HP1354; expression of this protein is predicted to be regulated by slipped-strand repair at the two (C) polynucleotide repeats; length of both repeats has been artificially adjusted (addition of one nucleotide in both cases) to give the full length protein NP_223991.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide NP_223992.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate NP_223993.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine NP_223994.1 similar to H. pylori 26695 gene HP1358 NP_223995.1 similar to H. pylori 26695 gene HP1359 NP_223996.1 UbiA prenyltransferase catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin NP_223997.1 similar to H. pylori 26695 gene HP1361 NP_223998.1 unwinds double stranded DNA NP_223999.1 similar to H. pylori 26695 gene HP1363 NP_224000.1 similar to H. pylori 26695 gene HP1364 NP_224001.1 similar to H. pylori 26695 gene HP1365 NP_224003.1 similar to H. pylori 26695 gene HP1371 NP_224004.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_224005.1 functions in MreBCD complex in some organisms NP_224006.1 binds and unfolds substrates as part of the ClpXP protease NP_224007.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_224008.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_224009.1 binds to flagellin and appears to stabilize flagellin during flagella assembly NP_224010.1 similar to H. pylori 26695 gene HP1378 NP_224011.1 similar to H. pylori 26695 gene HP1379 NP_224012.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_224013.1 similar to H. pylori 26695 gene HP1382 NP_224016.1 catalyzes the formation of biotin from dethiobiotin and sulfur NP_224017.1 similar to H. pylori 26695 gene HP1407 NP_224018.1 similar to H. pylori 26695 gene HP1408 NP_224019.1 similar to H. pylori 26695 gene HP1409 NP_224020.1 similar to H. pylori 26695 gene HP1409 NP_224021.1 similar to H. pylori 26695 gene HP1410 NP_224022.1 similar to H. pylori 26695 gene HP1411 NP_224023.1 similar to H. pylori 26695 gene HP1411 NP_224025.1 similar to H. pylori 26695 gene HP1412 NP_224026.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis NP_224027.1 similar to H. pylori 26695 gene HP1414 NP_224028.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_224029.1 similar to H. pylori 26695 gene HP1416 NP_224030.1 similar to TIGR HP1417; expression of this protein is predicted to be regulated by slipped-strand repair at the (AG) dinucleotide repeat; length of the repeat has been artificially adjusted (addition of one dinucleotide) to give the full length protein NP_224031.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_224032.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus NP_224033.1 involved in type III protein export during flagellum assembly NP_224034.1 similar to H. pylori 26695 gene HP1421 NP_224035.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme NP_224036.1 similar to H. pylori 26695 gene HP1423 NP_224037.1 similar to H. pylori 26695 gene HP1424 NP_224038.1 similar to H. pylori 26695 gene HP1427 NP_224039.1 similar to H. pylori 26695 gene HP1432 NP_224040.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_224041.1 similar to H. pylori 26695 gene HP1430 NP_224042.1 similar to H. pylori 26695 gene HP1429 NP_224043.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_224044.1 similar to H. pylori 26695 gene HP1433 NP_224045.1 similar to H. pylori 26695 gene HP1434 NP_224046.1 similar to H. pylori 26695 gene HP1435 NP_224047.1 similar to H. pylori 26695 gene HP1436 NP_224048.1 similar to H. pylori 26695 gene HP1437 NP_224049.1 similar to H. pylori 26695 gene HP1438 NP_224050.1 similar to H. pylori 26695 gene HP1439 NP_224051.1 similar to H. pylori 26695 gene HP1440 NP_224052.1 similar to H. pylori 26695 gene HP1441 NP_224053.1 affects carbohydrate metabolism, has regulatory role in many processes NP_224054.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis NP_224055.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_224056.1 similar to H. pylori 26695 gene HP1445 NP_224057.1 similar to H. pylori 26695 gene HP1446 NP_224058.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_224059.1 similar to H. pylori 26695 gene HP1448 NP_224060.1 similar to H. pylori 26695 gene HP1449 NP_224061.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_224062.1 similar to H. pylori 26695 gene HP1451 NP_224063.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_224064.1 similar to H. pylori 26695 gene HP1453 NP_224065.1 similar to H. pylori 26695 gene HP1454 NP_224066.1 similar to H. pylori 26695 gene HP1455 NP_224067.1 similar to H. pylori 26695 gene HP1456 NP_224068.1 similar to H. pylori 26695 gene HP1457 NP_224069.1 similar to H. pylori 26695 gene HP1458 NP_224070.1 similar to H. pylori 26695 gene HP1459 NP_224071.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase NP_224072.1 similar to H. pylori 26695 gene HP1461 NP_224073.1 similar to H. pylori 26695 gene HP1462 NP_224074.1 similar to H. pylori 26695 gene HP1463 NP_224075.1 similar to H. pylori 26695 gene HP1464 NP_224076.1 similar to H. pylori 26695 gene HP1465 NP_224077.1 similar to H. pylori 26695 gene HP1466 NP_224078.1 similar to H. pylori 26695 gene HP1467 NP_224079.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_224080.1 similar to H. pylori 26695 gene HP1469 NP_224081.1 similar to H. pylori 26695 gene HP1470 NP_224082.1 similar to H. pylori 26695 gene HP1471 NP_224083.1 similar to H. pylori 26695 gene HP1472 NP_224084.1 similar to H. pylori 26695 gene HP1473 NP_224085.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_224086.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_224087.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate NP_224088.1 required for the assembly of the flagellar basal body P-ring NP_224089.1 similar to H. pylori 26695 gene HP1478 NP_224090.1 similar to H. pylori 26695 gene HP1479 NP_224091.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_224092.1 similar to H. pylori 26695 gene HP1481 NP_224093.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_224094.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_224095.1 similar to H. pylori 26695 gene HP1484 NP_224096.1 similar to H. pylori 26695 gene HP1485 NP_224097.1 similar to H. pylori 26695 gene HP1486 NP_224098.1 similar to H. pylori 26695 gene HP1487 NP_224099.1 similar to H. pylori 26695 gene HP1488 NP_224100.1 similar to H. pylori 26695 gene HP1489 NP_224101.1 similar to H. pylori 26695 gene HP1490 NP_224102.1 similar to H. pylori 26695 gene HP1491 NP_224103.1 similar to H. pylori 26695 gene HP1492 NP_224104.1 similar to H. pylori 26695 gene HP1493 NP_224105.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_224106.1 Important for the balance of metabolites in the pentose-phosphate pathway NP_224107.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_224108.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_224109.1 similar to H. pylori 26695 gene HP1498 NP_224110.1 similar to H. pylori 26695 gene HP1499 NP_224111.1 similar to H. pylori 26695 gene HP1500 NP_224112.1 similar to H. pylori 26695 gene HP1501 NP_224113.1 similar to H. pylori 26695 gene HP1502 NP_224114.1 similar to H. pylori 26695 gene HP1503 NP_224115.1 similar to H. pylori 26695 gene HP1504 NP_224116.1 similar to H. pylori 26695 gene HP1505 NP_224117.1 similar to H. pylori 26695 gene HP1506 NP_224118.1 similar to H. pylori 26695 gene HP1507 NP_224119.1 similar to H. pylori 26695 gene HP1508 NP_224120.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX NP_224121.1 similar to H. pylori 26695 gene HP1510 NP_224122.1 similar to H. pylori 26695 gene HP1511 NP_224123.1 similar to H. pylori 26695 gene HP1512 NP_224124.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis NP_224125.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_224128.1 similar to H. pylori 26695 gene HP1521 NP_224129.1 similar to TIGR HP1522; expression of this protein is predicted to be regulated by slipped-strand repair at the (G) polynucleotide repeat; length of the repeat has been artificially adjusted (removal of one nucleotide) to give the full length protein NP_224130.1 catalyzes branch migration in Holliday junction intermediates NP_224131.1 similar to H. pylori 26695 gene HP1524 NP_224132.1 similar to H. pylori 26695 gene HP1525 NP_224133.1 AP endonuclease xth family; multifunctional DNA repair protein; has AP endonuclease, 3'-5' exonuclease, ribonuclease H, and 3'-phosphomonoesterase activities. NP_224134.1 similar to H. pylori 26695 gene HP1527 NP_224135.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_224136.1 similar to H. pylori 26695 gene HP1530 NP_224137.1 similar to H. pylori 26695 gene HP1531 NP_224138.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_224139.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor NP_224141.1 similar to H. pylori 26695 gene HP1403 NP_224142.1 similar to H. pylori 26695 gene HP1402 NP_224143.1 similar to H. pylori 26695 gene HP1401 NP_224144.1 similar to H. pylori 26695 gene HP1400 NP_224145.1 similar to H. pylori 26695 gene HP1399 NP_224146.1 similar to H. pylori 26695 gene HP1398 NP_224148.1 similar to H. pylori 26695 gene HP1397 NP_224149.1 similar to H. pylori 26695 gene HP1396 NP_224150.1 similar to H. pylori 26695 gene HP1395 NP_224151.1 similar to H. pylori 26695 gene HP1394 NP_224152.1 similar to H. pylori 26695 gene HP1393 NP_224153.1 similar to H. pylori 26695 gene HP1392 NP_224154.1 similar to H. pylori 26695 gene HP1391 NP_224156.1 3'-5' exonuclease of DNA polymerase III NP_224157.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate NP_224158.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate NP_224159.1 similar to H. pylori 26695 gene HP1384 NP_224160.1 similar to TIGR HP1366; expression of this protein is predicted to be regulated by slipped-strand repair at the (A) polynucleotide repeat; length of the repeat has been artificially adjusted (removal of one nucleotide) to give the full length protein NP_224161.1 similar to H. pylori 26695 gene HP1365 NP_224162.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_224163.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_224164.1 similar to H. pylori 26695 gene HP1553 NP_224165.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH NP_224166.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex NP_224167.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane NP_224168.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_224169.1 similar to H. pylori 26695 gene HP1548 NP_224170.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_224171.1 similar to H. pylori 26695 gene HP1546 NP_224172.1 similar to H. pylori 26695 gene HP1545 NP_224173.1 similar to H. pylori 26695 gene HP1544 NP_224174.1 similar to H. pylori 26695 gene HP1543 NP_224175.1 similar to H. pylori 26695 gene HP1542 NP_224176.1 similar to H. pylori 26695 gene HP1541 NP_224177.1 similar to H. pylori 26695 gene HP1540 NP_224178.1 similar to H. pylori 26695 gene HP1539 NP_224179.1 similar to H. pylori 26695 gene HP1538 NP_224182.1 similar to H. pylori 26695 gene HP1556 NP_224183.1 forms a junction between the M-ring and FlgB during flagella biosynthesis NP_224184.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod NP_224185.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella NP_224186.1 similar to H. pylori 26695 gene HP1560 NP_224187.1 similar to H. pylori 26695 gene HP1561 NP_224188.1 similar to H. pylori 26695 gene HP1562 NP_224189.1 similar to H. pylori 26695 gene HP1563 NP_224190.1 similar to H. pylori 26695 gene HP1564 NP_224191.1 similar to H. pylori 26695 gene HP1565 NP_224192.1 similar to H. pylori 26695 gene HP1566 NP_224193.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_224194.1 similar to H. pylori 26695 gene HP1568 NP_224195.1 similar to H. pylori 26695 gene HP1569 NP_224196.1 similar to H. pylori 26695 gene HP1570 NP_224197.1 similar to H. pylori 26695 gene HP1571 NP_224198.1 similar to H. pylori 26695 gene HP1572 NP_224199.1 similar to H. pylori 26695 gene HP1573 NP_224200.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_224201.1 similar to H. pylori 26695 gene HP1575 NP_224202.1 part of the metNIQ transport system for methionine NP_224203.1 similar to H. pylori 26695 gene HP1577 NP_224204.1 similar to H. pylori 26695 gene HP1579 NP_224205.1 similar to H. pylori 26695 gene HP1580 NP_224206.1 similar to H. pylori 26695 gene HP1581 NP_224207.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) NP_224208.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) NP_224209.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_224210.1 makes up the distal portion of the flagellar basal body rod NP_224211.1 similar to H. pylori 26695 gene HP1587 NP_224212.1 similar to H. pylori 26695 gene HP1588