-- dump date   	20140619_113628
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1248725000001	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1248725000002	putative RNA binding site [nucleotide binding]; other site
1248725000003	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1248725000004	homopentamer interface [polypeptide binding]; other site
1248725000005	active site
1248725000006	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1248725000007	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1248725000008	active site clefts [active]
1248725000009	zinc binding site [ion binding]; other site
1248725000010	dimer interface [polypeptide binding]; other site
1248725000011	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1248725000012	active site
1248725000013	dimer interface [polypeptide binding]; other site
1248725000014	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1248725000015	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1248725000016	active site
1248725000017	ATP-binding site [chemical binding]; other site
1248725000018	pantoate-binding site; other site
1248725000019	HXXH motif; other site
1248725000020	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000021	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1248725000022	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1248725000023	ring oligomerisation interface [polypeptide binding]; other site
1248725000024	ATP/Mg binding site [chemical binding]; other site
1248725000025	stacking interactions; other site
1248725000026	hinge regions; other site
1248725000027	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1248725000028	oligomerisation interface [polypeptide binding]; other site
1248725000029	mobile loop; other site
1248725000030	roof hairpin; other site
1248725000031	DNA primase, catalytic core; Region: dnaG; TIGR01391
1248725000032	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1248725000033	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1248725000034	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1248725000035	active site
1248725000036	metal binding site [ion binding]; metal-binding site
1248725000037	interdomain interaction site; other site
1248725000038	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1248725000039	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1248725000040	Ligand Binding Site [chemical binding]; other site
1248725000041	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1248725000042	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1248725000043	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1248725000044	Walker A motif; other site
1248725000045	ATP binding site [chemical binding]; other site
1248725000046	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1248725000047	Walker B motif; other site
1248725000048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
1248725000049	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1248725000050	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1248725000051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725000052	active site
1248725000053	phosphorylation site [posttranslational modification]
1248725000054	intermolecular recognition site; other site
1248725000055	dimerization interface [polypeptide binding]; other site
1248725000056	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1248725000057	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1248725000058	dimer interface [polypeptide binding]; other site
1248725000059	active site
1248725000060	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1248725000061	catalytic residues [active]
1248725000062	substrate binding site [chemical binding]; other site
1248725000063	lipid A 1-phosphatase; Reviewed; Region: PRK09597
1248725000064	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1248725000065	active site
1248725000066	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
1248725000067	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1248725000068	Sulfatase; Region: Sulfatase; pfam00884
1248725000069	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000070	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
1248725000071	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1248725000072	prephenate dehydrogenase; Validated; Region: PRK08507
1248725000073	Prephenate dehydrogenase; Region: PDH; pfam02153
1248725000074	ATP-dependent protease La; Region: lon; TIGR00763
1248725000075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725000076	Walker A motif; other site
1248725000077	ATP binding site [chemical binding]; other site
1248725000078	Walker B motif; other site
1248725000079	arginine finger; other site
1248725000080	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1248725000081	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
1248725000082	flagellar assembly protein FliW; Provisional; Region: PRK13282
1248725000083	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1248725000084	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1248725000085	acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852
1248725000086	active site
1248725000087	endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382
1248725000088	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1248725000089	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1248725000090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725000091	Walker A motif; other site
1248725000092	ATP binding site [chemical binding]; other site
1248725000093	Walker B motif; other site
1248725000094	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1248725000095	rod shape-determining protein MreB; Provisional; Region: PRK13927
1248725000096	MreB and similar proteins; Region: MreB_like; cd10225
1248725000097	nucleotide binding site [chemical binding]; other site
1248725000098	Mg binding site [ion binding]; other site
1248725000099	putative protofilament interaction site [polypeptide binding]; other site
1248725000100	RodZ interaction site [polypeptide binding]; other site
1248725000101	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1248725000102	rod shape-determining protein MreC; Region: MreC; pfam04085
1248725000103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1248725000104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725000105	active site
1248725000106	phosphorylation site [posttranslational modification]
1248725000107	intermolecular recognition site; other site
1248725000108	dimerization interface [polypeptide binding]; other site
1248725000109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1248725000110	DNA binding site [nucleotide binding]
1248725000111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1248725000112	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1248725000113	dimer interface [polypeptide binding]; other site
1248725000114	phosphorylation site [posttranslational modification]
1248725000115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725000116	ATP binding site [chemical binding]; other site
1248725000117	Mg2+ binding site [ion binding]; other site
1248725000118	G-X-G motif; other site
1248725000119	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
1248725000120	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1248725000121	putative substrate binding site [chemical binding]; other site
1248725000122	putative ATP binding site [chemical binding]; other site
1248725000123	replicative DNA helicase; Provisional; Region: PRK08506
1248725000124	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1248725000125	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1248725000126	Walker A motif; other site
1248725000127	ATP binding site [chemical binding]; other site
1248725000128	Walker B motif; other site
1248725000129	DNA binding loops [nucleotide binding]
1248725000130	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1248725000131	Competence protein; Region: Competence; pfam03772
1248725000132	prenyltransferase; Reviewed; Region: ubiA; PRK12874
1248725000133	UbiA prenyltransferase family; Region: UbiA; pfam01040
1248725000134	phosphatidylserine decarboxylase; Provisional; Region: PRK03934
1248725000135	quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550
1248725000136	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848
1248725000137	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1248725000138	dimerization interface [polypeptide binding]; other site
1248725000139	active site
1248725000140	Predicted helicase [General function prediction only]; Region: COG4889
1248725000141	Predicted helicase [General function prediction only]; Region: COG4889
1248725000142	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725000143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725000144	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1248725000145	C-terminal peptidase (prc); Region: prc; TIGR00225
1248725000146	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1248725000147	protein binding site [polypeptide binding]; other site
1248725000148	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1248725000149	Catalytic dyad [active]
1248725000150	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1248725000151	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1248725000152	putative acyl-acceptor binding pocket; other site
1248725000153	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1248725000154	ligand binding site [chemical binding]; other site
1248725000155	active site
1248725000156	UGI interface [polypeptide binding]; other site
1248725000157	catalytic site [active]
1248725000158	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1248725000159	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1248725000160	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1248725000161	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1248725000162	Phosphoglycerate kinase; Region: PGK; pfam00162
1248725000163	substrate binding site [chemical binding]; other site
1248725000164	hinge regions; other site
1248725000165	ADP binding site [chemical binding]; other site
1248725000166	catalytic site [active]
1248725000167	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1248725000168	Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836
1248725000169	Cl binding site [ion binding]; other site
1248725000170	oligomer interface [polypeptide binding]; other site
1248725000171	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1248725000172	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725000173	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000174	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1248725000175	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1248725000176	cofactor binding site; other site
1248725000177	DNA binding site [nucleotide binding]
1248725000178	substrate interaction site [chemical binding]; other site
1248725000179	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1248725000180	HNH endonuclease; Region: HNH; pfam01844
1248725000181	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1248725000182	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000183	Tsp45I type II restriction enzyme; Region: Tsp45I; pfam06300
1248725000184	Tsp45I type II restriction enzyme; Region: Tsp45I; pfam06300
1248725000185	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1248725000186	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1248725000187	Na binding site [ion binding]; other site
1248725000188	Proline dehydrogenase; Region: Pro_dh; pfam01619
1248725000189	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1248725000190	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1248725000191	Glutamate binding site [chemical binding]; other site
1248725000192	NAD binding site [chemical binding]; other site
1248725000193	catalytic residues [active]
1248725000194	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1248725000195	Immunoglobulin domain; Region: Ig; cl11960
1248725000196	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1248725000197	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
1248725000198	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
1248725000199	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1248725000200	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1248725000201	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1248725000202	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1248725000203	G1 box; other site
1248725000204	GTP/Mg2+ binding site [chemical binding]; other site
1248725000205	G2 box; other site
1248725000206	Switch I region; other site
1248725000207	G3 box; other site
1248725000208	Switch II region; other site
1248725000209	G4 box; other site
1248725000210	G5 box; other site
1248725000211	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1248725000212	UreF; Region: UreF; pfam01730
1248725000213	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1248725000214	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1248725000215	dimer interface [polypeptide binding]; other site
1248725000216	catalytic residues [active]
1248725000217	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
1248725000218	urease subunit beta; Provisional; Region: ureB; PRK13985
1248725000219	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1248725000220	subunit interactions [polypeptide binding]; other site
1248725000221	active site
1248725000222	flap region; other site
1248725000223	urease subunit alpha; Provisional; Region: PRK13986
1248725000224	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1248725000225	alpha-gamma subunit interface [polypeptide binding]; other site
1248725000226	beta-gamma subunit interface [polypeptide binding]; other site
1248725000227	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1248725000228	gamma-beta subunit interface [polypeptide binding]; other site
1248725000229	alpha-beta subunit interface [polypeptide binding]; other site
1248725000230	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1248725000231	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324
1248725000232	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1248725000233	active site
1248725000234	substrate binding site [chemical binding]; other site
1248725000235	metal binding site [ion binding]; metal-binding site
1248725000236	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1248725000237	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1248725000238	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1248725000239	RF-1 domain; Region: RF-1; pfam00472
1248725000240	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000241	Cache domain; Region: Cache_1; pfam02743
1248725000242	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1248725000243	dimer interface [polypeptide binding]; other site
1248725000244	putative CheW interface [polypeptide binding]; other site
1248725000245	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1248725000246	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1248725000247	23S rRNA interface [nucleotide binding]; other site
1248725000248	L3 interface [polypeptide binding]; other site
1248725000249	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1248725000250	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1248725000251	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
1248725000252	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1248725000253	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
1248725000254	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1248725000255	NlpC/P60 family; Region: NLPC_P60; cl17555
1248725000256	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1248725000257	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1248725000258	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1248725000259	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1248725000260	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1248725000261	DNA binding residues [nucleotide binding]
1248725000262	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1248725000263	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1248725000264	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1248725000265	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1248725000266	DpnII restriction endonuclease; Region: DpnII; pfam04556
1248725000267	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725000268	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725000269	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000270	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
1248725000271	GDP-Fucose binding site [chemical binding]; other site
1248725000272	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
1248725000273	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
1248725000274	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1248725000275	putative ligand binding site [chemical binding]; other site
1248725000276	putative NAD binding site [chemical binding]; other site
1248725000277	catalytic site [active]
1248725000278	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1248725000279	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1248725000280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725000281	catalytic residue [active]
1248725000282	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1248725000283	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1248725000284	dimer interface [polypeptide binding]; other site
1248725000285	putative CheW interface [polypeptide binding]; other site
1248725000286	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
1248725000287	Ligand Binding Site [chemical binding]; other site
1248725000288	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000289	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1248725000290	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1248725000291	metal-binding site
1248725000292	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1248725000293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1248725000294	dimerization interface [polypeptide binding]; other site
1248725000295	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1248725000296	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1248725000297	dimer interface [polypeptide binding]; other site
1248725000298	putative CheW interface [polypeptide binding]; other site
1248725000299	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1248725000300	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1248725000301	active site
1248725000302	metal binding site [ion binding]; metal-binding site
1248725000303	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1248725000304	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1248725000305	cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176
1248725000306	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1248725000307	homodimer interface [polypeptide binding]; other site
1248725000308	substrate-cofactor binding pocket; other site
1248725000309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725000310	catalytic residue [active]
1248725000311	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1248725000312	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1248725000313	dimer interface [polypeptide binding]; other site
1248725000314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725000315	catalytic residue [active]
1248725000316	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1248725000317	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1248725000318	nucleotide binding site [chemical binding]; other site
1248725000319	NEF interaction site [polypeptide binding]; other site
1248725000320	SBD interface [polypeptide binding]; other site
1248725000321	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1248725000322	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1248725000323	dimer interface [polypeptide binding]; other site
1248725000324	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1248725000325	heat-inducible transcription repressor; Provisional; Region: PRK03911
1248725000326	hypothetical protein; Provisional; Region: PRK05834
1248725000327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
1248725000328	flagellin B; Provisional; Region: PRK13588
1248725000329	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1248725000330	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1248725000331	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1248725000332	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1248725000333	DNA topoisomerase I; Validated; Region: PRK05582
1248725000334	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1248725000335	active site
1248725000336	interdomain interaction site; other site
1248725000337	putative metal-binding site [ion binding]; other site
1248725000338	nucleotide binding site [chemical binding]; other site
1248725000339	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1248725000340	domain I; other site
1248725000341	DNA binding groove [nucleotide binding]
1248725000342	phosphate binding site [ion binding]; other site
1248725000343	domain II; other site
1248725000344	domain III; other site
1248725000345	nucleotide binding site [chemical binding]; other site
1248725000346	catalytic site [active]
1248725000347	domain IV; other site
1248725000348	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1248725000349	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1248725000350	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1248725000351	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
1248725000352	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725000353	FeS/SAM binding site; other site
1248725000354	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
1248725000355	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1248725000356	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1248725000357	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1248725000358	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1248725000359	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1248725000360	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1248725000361	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1248725000362	active site
1248725000363	dimer interface [polypeptide binding]; other site
1248725000364	motif 1; other site
1248725000365	motif 2; other site
1248725000366	motif 3; other site
1248725000367	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1248725000368	anticodon binding site; other site
1248725000369	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1248725000370	translation initiation factor IF-3; Region: infC; TIGR00168
1248725000371	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1248725000372	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1248725000373	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1248725000374	23S rRNA binding site [nucleotide binding]; other site
1248725000375	L21 binding site [polypeptide binding]; other site
1248725000376	L13 binding site [polypeptide binding]; other site
1248725000377	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000378	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
1248725000379	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1248725000380	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1248725000381	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1248725000382	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1248725000383	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1248725000384	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
1248725000385	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1248725000386	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1248725000387	catalytic triad [active]
1248725000388	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1248725000389	iron-sulfur cluster-binding protein; Region: TIGR00273
1248725000390	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1248725000391	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1248725000392	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1248725000393	Cysteine-rich domain; Region: CCG; pfam02754
1248725000394	Cysteine-rich domain; Region: CCG; pfam02754
1248725000395	L-lactate transport; Region: lctP; TIGR00795
1248725000396	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1248725000397	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1248725000398	L-lactate permease; Region: Lactate_perm; pfam02652
1248725000399	DNA glycosylase MutY; Provisional; Region: PRK13910
1248725000400	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1248725000401	minor groove reading motif; other site
1248725000402	helix-hairpin-helix signature motif; other site
1248725000403	substrate binding pocket [chemical binding]; other site
1248725000404	active site
1248725000405	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1248725000406	DNA binding and oxoG recognition site [nucleotide binding]
1248725000407	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1248725000408	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1248725000409	transmembrane helices; other site
1248725000410	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1248725000411	Low-spin heme binding site [chemical binding]; other site
1248725000412	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1248725000413	D-pathway; other site
1248725000414	Putative water exit pathway; other site
1248725000415	Binuclear center (active site) [active]
1248725000416	K-pathway; other site
1248725000417	Putative proton exit pathway; other site
1248725000418	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1248725000419	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
1248725000420	cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736
1248725000421	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1248725000422	Cytochrome c; Region: Cytochrom_C; pfam00034
1248725000423	Cytochrome c; Region: Cytochrom_C; pfam00034
1248725000424	Family of unknown function (DUF4006); Region: DUF4006; pfam13179
1248725000425	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
1248725000426	recombinase A; Provisional; Region: recA; PRK09354
1248725000427	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1248725000428	hexamer interface [polypeptide binding]; other site
1248725000429	Walker A motif; other site
1248725000430	ATP binding site [chemical binding]; other site
1248725000431	Walker B motif; other site
1248725000432	enolase; Provisional; Region: eno; PRK00077
1248725000433	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1248725000434	dimer interface [polypeptide binding]; other site
1248725000435	metal binding site [ion binding]; metal-binding site
1248725000436	substrate binding pocket [chemical binding]; other site
1248725000437	AMIN domain; Region: AMIN; pfam11741
1248725000438	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1248725000439	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1248725000440	ADP binding site [chemical binding]; other site
1248725000441	magnesium binding site [ion binding]; other site
1248725000442	putative shikimate binding site; other site
1248725000443	Cache domain; Region: Cache_1; pfam02743
1248725000444	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725000445	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1248725000446	Ligand binding site; other site
1248725000447	metal-binding site
1248725000448	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725000449	Sel1-like repeats; Region: SEL1; smart00671
1248725000450	Sel1-like repeats; Region: SEL1; smart00671
1248725000451	Sel1-like repeats; Region: SEL1; smart00671
1248725000452	Sel1-like repeats; Region: SEL1; smart00671
1248725000453	Sel1-like repeats; Region: SEL1; smart00671
1248725000454	Sel1-like repeats; Region: SEL1; smart00671
1248725000455	hypothetical protein; Provisional; Region: PRK12378
1248725000456	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1248725000457	dimer interface [polypeptide binding]; other site
1248725000458	active site
1248725000459	Schiff base residues; other site
1248725000460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1248725000461	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1248725000462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1248725000463	dimer interface [polypeptide binding]; other site
1248725000464	phosphorylation site [posttranslational modification]
1248725000465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725000466	ATP binding site [chemical binding]; other site
1248725000467	Mg2+ binding site [ion binding]; other site
1248725000468	G-X-G motif; other site
1248725000469	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1248725000470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725000471	active site
1248725000472	phosphorylation site [posttranslational modification]
1248725000473	intermolecular recognition site; other site
1248725000474	dimerization interface [polypeptide binding]; other site
1248725000475	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1248725000476	DNA binding site [nucleotide binding]
1248725000477	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1248725000478	Peptidase family U32; Region: Peptidase_U32; pfam01136
1248725000479	peptide chain release factor 2; Region: prfB; TIGR00020
1248725000480	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1248725000481	RF-1 domain; Region: RF-1; pfam00472
1248725000482	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1248725000483	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1248725000484	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1248725000485	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
1248725000486	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
1248725000487	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1248725000488	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1248725000489	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1248725000490	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1248725000491	intersubunit interface [polypeptide binding]; other site
1248725000492	active site
1248725000493	zinc binding site [ion binding]; other site
1248725000494	Na+ binding site [ion binding]; other site
1248725000495	elongation factor P; Validated; Region: PRK00529
1248725000496	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1248725000497	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1248725000498	RNA binding site [nucleotide binding]; other site
1248725000499	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1248725000500	RNA binding site [nucleotide binding]; other site
1248725000501	pseudaminic acid synthase; Region: PseI; TIGR03586
1248725000502	NeuB family; Region: NeuB; pfam03102
1248725000503	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1248725000504	NeuB binding interface [polypeptide binding]; other site
1248725000505	putative substrate binding site [chemical binding]; other site
1248725000506	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1248725000507	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1248725000508	Walker A/P-loop; other site
1248725000509	ATP binding site [chemical binding]; other site
1248725000510	Q-loop/lid; other site
1248725000511	ABC transporter signature motif; other site
1248725000512	Walker B; other site
1248725000513	D-loop; other site
1248725000514	H-loop/switch region; other site
1248725000515	apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291
1248725000516	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1248725000517	active site
1248725000518	catalytic triad [active]
1248725000519	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1248725000520	Colicin V production protein; Region: Colicin_V; pfam02674
1248725000521	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1248725000522	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1248725000523	dimer interface [polypeptide binding]; other site
1248725000524	putative anticodon binding site; other site
1248725000525	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1248725000526	motif 1; other site
1248725000527	active site
1248725000528	motif 2; other site
1248725000529	motif 3; other site
1248725000530	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1248725000531	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1248725000532	dimer interface [polypeptide binding]; other site
1248725000533	active site
1248725000534	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1248725000535	folate binding site [chemical binding]; other site
1248725000536	Domain of unknown function (DUF1882); Region: DUF1882; pfam08966
1248725000537	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1248725000538	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725000539	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725000540	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725000541	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
1248725000542	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1248725000543	PLD-like domain; Region: PLDc_2; pfam13091
1248725000544	putative active site [active]
1248725000545	catalytic site [active]
1248725000546	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1248725000547	PLD-like domain; Region: PLDc_2; pfam13091
1248725000548	putative active site [active]
1248725000549	catalytic site [active]
1248725000550	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
1248725000551	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1248725000552	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1248725000553	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
1248725000554	L-aspartate oxidase; Provisional; Region: PRK06175
1248725000555	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1248725000556	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553
1248725000557	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
1248725000558	Iron-sulfur protein interface; other site
1248725000559	proximal heme binding site [chemical binding]; other site
1248725000560	distal heme binding site [chemical binding]; other site
1248725000561	dimer interface [polypeptide binding]; other site
1248725000562	triosephosphate isomerase; Provisional; Region: PRK14567
1248725000563	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1248725000564	substrate binding site [chemical binding]; other site
1248725000565	dimer interface [polypeptide binding]; other site
1248725000566	catalytic triad [active]
1248725000567	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415
1248725000568	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1248725000569	NAD binding site [chemical binding]; other site
1248725000570	homotetramer interface [polypeptide binding]; other site
1248725000571	homodimer interface [polypeptide binding]; other site
1248725000572	substrate binding site [chemical binding]; other site
1248725000573	active site
1248725000574	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
1248725000575	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1248725000576	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1248725000577	trimer interface [polypeptide binding]; other site
1248725000578	active site
1248725000579	UDP-GlcNAc binding site [chemical binding]; other site
1248725000580	lipid binding site [chemical binding]; lipid-binding site
1248725000581	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1248725000582	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1248725000583	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1248725000584	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1248725000585	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1248725000586	active site
1248725000587	multimer interface [polypeptide binding]; other site
1248725000588	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1248725000589	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
1248725000590	fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182
1248725000591	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
1248725000592	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1248725000593	dimer interface [polypeptide binding]; other site
1248725000594	active site
1248725000595	CoA binding pocket [chemical binding]; other site
1248725000596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725000597	Walker B; other site
1248725000598	D-loop; other site
1248725000599	H-loop/switch region; other site
1248725000600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725000601	Walker A/P-loop; other site
1248725000602	ATP binding site [chemical binding]; other site
1248725000603	antiporter inner membrane protein; Provisional; Region: PRK11670
1248725000604	Domain of unknown function DUF59; Region: DUF59; pfam01883
1248725000605	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1248725000606	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725000607	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1248725000608	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725000609	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1248725000610	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725000611	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725000612	heat shock protein 90; Provisional; Region: PRK05218
1248725000613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725000614	ATP binding site [chemical binding]; other site
1248725000615	Mg2+ binding site [ion binding]; other site
1248725000616	G-X-G motif; other site
1248725000617	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725000618	Sel1-like repeats; Region: SEL1; smart00671
1248725000619	Sel1-like repeats; Region: SEL1; smart00671
1248725000620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725000621	TPR motif; other site
1248725000622	binding surface
1248725000623	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1248725000624	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1248725000625	metal binding site [ion binding]; metal-binding site
1248725000626	dimer interface [polypeptide binding]; other site
1248725000627	glucose-inhibited division protein A; Region: gidA; TIGR00136
1248725000628	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1248725000629	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1248725000630	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1248725000631	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1248725000632	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1248725000633	transmembrane helices; other site
1248725000634	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1248725000635	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1248725000636	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243
1248725000637	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1248725000638	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1248725000639	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1248725000640	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1248725000641	substrate binding site [chemical binding]; other site
1248725000642	Helix-turn-helix domain; Region: HTH_28; pfam13518
1248725000643	cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403
1248725000644	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1248725000645	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1248725000646	catalytic residue [active]
1248725000647	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
1248725000648	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1248725000649	trimerization site [polypeptide binding]; other site
1248725000650	active site
1248725000651	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1248725000652	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1248725000653	DNA repair protein RadA; Region: sms; TIGR00416
1248725000654	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1248725000655	Walker A motif/ATP binding site; other site
1248725000656	ATP binding site [chemical binding]; other site
1248725000657	Walker B motif; other site
1248725000658	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1248725000659	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1248725000660	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1248725000661	SelR domain; Region: SelR; pfam01641
1248725000662	Predicted permeases [General function prediction only]; Region: COG0730
1248725000663	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000664	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1248725000665	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1248725000666	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1248725000667	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000668	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1248725000669	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1248725000670	Ligand binding site; other site
1248725000671	oligomer interface; other site
1248725000672	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1248725000673	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1248725000674	hypothetical protein; Provisional; Region: PRK04081
1248725000675	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1248725000676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1248725000677	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725000678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725000679	binding surface
1248725000680	TPR motif; other site
1248725000681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725000682	binding surface
1248725000683	TPR motif; other site
1248725000684	Sel1-like repeats; Region: SEL1; smart00671
1248725000685	Sel1-like repeats; Region: SEL1; smart00671
1248725000686	Cytochrome c; Region: Cytochrom_C; cl11414
1248725000687	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
1248725000688	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1248725000689	domain interfaces; other site
1248725000690	active site
1248725000691	prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409
1248725000692	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1248725000693	dimer interface [polypeptide binding]; other site
1248725000694	motif 1; other site
1248725000695	active site
1248725000696	motif 2; other site
1248725000697	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1248725000698	putative deacylase active site [active]
1248725000699	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1248725000700	active site
1248725000701	motif 3; other site
1248725000702	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1248725000703	anticodon binding site; other site
1248725000704	glutamyl-tRNA reductase; Region: hemA; TIGR01035
1248725000705	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1248725000706	tRNA; other site
1248725000707	putative tRNA binding site [nucleotide binding]; other site
1248725000708	putative NADP binding site [chemical binding]; other site
1248725000709	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1248725000710	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1248725000711	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1248725000712	substrate binding pocket [chemical binding]; other site
1248725000713	chain length determination region; other site
1248725000714	substrate-Mg2+ binding site; other site
1248725000715	catalytic residues [active]
1248725000716	aspartate-rich region 1; other site
1248725000717	active site lid residues [active]
1248725000718	aspartate-rich region 2; other site
1248725000719	Domain of unknown function (DUF2018); Region: DUF2018; pfam09442
1248725000720	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1248725000721	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1248725000722	dimerization interface [polypeptide binding]; other site
1248725000723	DPS ferroxidase diiron center [ion binding]; other site
1248725000724	ion pore; other site
1248725000725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1248725000726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1248725000727	dimer interface [polypeptide binding]; other site
1248725000728	phosphorylation site [posttranslational modification]
1248725000729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725000730	ATP binding site [chemical binding]; other site
1248725000731	Mg2+ binding site [ion binding]; other site
1248725000732	G-X-G motif; other site
1248725000733	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1248725000734	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1248725000735	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1248725000736	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1248725000737	ATP binding site [chemical binding]; other site
1248725000738	Mg++ binding site [ion binding]; other site
1248725000739	motif III; other site
1248725000740	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725000741	nucleotide binding region [chemical binding]; other site
1248725000742	ATP-binding site [chemical binding]; other site
1248725000743	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1248725000744	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1248725000745	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
1248725000746	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1248725000747	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1248725000748	Walker A/P-loop; other site
1248725000749	ATP binding site [chemical binding]; other site
1248725000750	Q-loop/lid; other site
1248725000751	ABC transporter signature motif; other site
1248725000752	Walker B; other site
1248725000753	D-loop; other site
1248725000754	H-loop/switch region; other site
1248725000755	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1248725000756	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1248725000757	Walker A/P-loop; other site
1248725000758	ATP binding site [chemical binding]; other site
1248725000759	Q-loop/lid; other site
1248725000760	ABC transporter signature motif; other site
1248725000761	Walker B; other site
1248725000762	D-loop; other site
1248725000763	H-loop/switch region; other site
1248725000764	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1248725000765	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1248725000766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725000767	dimer interface [polypeptide binding]; other site
1248725000768	conserved gate region; other site
1248725000769	putative PBP binding loops; other site
1248725000770	ABC-ATPase subunit interface; other site
1248725000771	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000772	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000773	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1248725000774	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1248725000775	GDP-binding site [chemical binding]; other site
1248725000776	ACT binding site; other site
1248725000777	IMP binding site; other site
1248725000778	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1248725000779	RIP metalloprotease RseP; Region: TIGR00054
1248725000780	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1248725000781	active site
1248725000782	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1248725000783	protein binding site [polypeptide binding]; other site
1248725000784	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1248725000785	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
1248725000786	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1248725000787	generic binding surface II; other site
1248725000788	generic binding surface I; other site
1248725000789	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1248725000790	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000791	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000792	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725000793	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000794	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1248725000795	Clp amino terminal domain; Region: Clp_N; pfam02861
1248725000796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725000797	Walker A motif; other site
1248725000798	ATP binding site [chemical binding]; other site
1248725000799	Walker B motif; other site
1248725000800	arginine finger; other site
1248725000801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725000802	Walker A motif; other site
1248725000803	ATP binding site [chemical binding]; other site
1248725000804	Walker B motif; other site
1248725000805	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1248725000806	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1248725000807	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1248725000808	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
1248725000809	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1248725000810	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1248725000811	active site
1248725000812	chlorohydrolase; Provisional; Region: PRK08418
1248725000813	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
1248725000814	active site
1248725000815	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1248725000816	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339
1248725000817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725000818	FeS/SAM binding site; other site
1248725000819	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1248725000820	putative acyl-acceptor binding pocket; other site
1248725000821	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1248725000822	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1248725000823	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1248725000824	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1248725000825	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1248725000826	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1248725000827	putative active site [active]
1248725000828	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1248725000829	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1248725000830	putative acyl-acceptor binding pocket; other site
1248725000831	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1248725000832	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
1248725000833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400
1248725000834	TrkA-C domain; Region: TrkA_C; pfam02080
1248725000835	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1248725000836	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1248725000837	active site
1248725000838	dimer interface [polypeptide binding]; other site
1248725000839	metal binding site [ion binding]; metal-binding site
1248725000840	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1248725000841	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1248725000842	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
1248725000843	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1248725000844	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725000845	FeS/SAM binding site; other site
1248725000846	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1248725000847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725000848	Walker A motif; other site
1248725000849	ATP binding site [chemical binding]; other site
1248725000850	Walker B motif; other site
1248725000851	arginine finger; other site
1248725000852	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
1248725000853	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725000854	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725000855	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1248725000856	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725000857	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1248725000858	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1248725000859	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1248725000860	active site
1248725000861	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1248725000862	substrate binding site [chemical binding]; other site
1248725000863	catalytic residues [active]
1248725000864	dimer interface [polypeptide binding]; other site
1248725000865	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
1248725000866	Uncharacterized conserved protein [Function unknown]; Region: COG4866
1248725000867	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1248725000868	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1248725000869	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1248725000870	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1248725000871	substrate-cofactor binding pocket; other site
1248725000872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725000873	catalytic residue [active]
1248725000874	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
1248725000875	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
1248725000876	multimer interface [polypeptide binding]; other site
1248725000877	active site
1248725000878	catalytic triad [active]
1248725000879	dimer interface [polypeptide binding]; other site
1248725000880	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412
1248725000881	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1248725000882	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1248725000883	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1248725000884	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1248725000885	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1248725000886	peptide binding site [polypeptide binding]; other site
1248725000887	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1248725000888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725000889	dimer interface [polypeptide binding]; other site
1248725000890	conserved gate region; other site
1248725000891	putative PBP binding loops; other site
1248725000892	ABC-ATPase subunit interface; other site
1248725000893	dipeptide transporter; Provisional; Region: PRK10913
1248725000894	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1248725000895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725000896	dimer interface [polypeptide binding]; other site
1248725000897	conserved gate region; other site
1248725000898	putative PBP binding loops; other site
1248725000899	ABC-ATPase subunit interface; other site
1248725000900	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1248725000901	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1248725000902	Walker A/P-loop; other site
1248725000903	ATP binding site [chemical binding]; other site
1248725000904	Q-loop/lid; other site
1248725000905	ABC transporter signature motif; other site
1248725000906	Walker B; other site
1248725000907	D-loop; other site
1248725000908	H-loop/switch region; other site
1248725000909	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1248725000910	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1248725000911	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1248725000912	Walker A/P-loop; other site
1248725000913	ATP binding site [chemical binding]; other site
1248725000914	Q-loop/lid; other site
1248725000915	ABC transporter signature motif; other site
1248725000916	Walker B; other site
1248725000917	D-loop; other site
1248725000918	H-loop/switch region; other site
1248725000919	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1248725000920	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1248725000921	GTP1/OBG; Region: GTP1_OBG; pfam01018
1248725000922	Obg GTPase; Region: Obg; cd01898
1248725000923	G1 box; other site
1248725000924	GTP/Mg2+ binding site [chemical binding]; other site
1248725000925	Switch I region; other site
1248725000926	G2 box; other site
1248725000927	G3 box; other site
1248725000928	Switch II region; other site
1248725000929	G4 box; other site
1248725000930	G5 box; other site
1248725000931	Alginate lyase; Region: Alginate_lyase; pfam05426
1248725000932	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1248725000933	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1248725000934	inhibitor-cofactor binding pocket; inhibition site
1248725000935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725000936	catalytic residue [active]
1248725000937	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
1248725000938	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1248725000939	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1248725000940	active site
1248725000941	catalytic triad [active]
1248725000942	dimer interface [polypeptide binding]; other site
1248725000943	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
1248725000944	active site
1248725000945	catalytic site [active]
1248725000946	Zn binding site [ion binding]; other site
1248725000947	tetramer interface [polypeptide binding]; other site
1248725000948	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1248725000949	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725000950	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725000951	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1248725000952	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1248725000953	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1248725000954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725000955	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1248725000956	putative substrate translocation pore; other site
1248725000957	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
1248725000958	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
1248725000959	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1248725000960	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1248725000961	arginyl-tRNA synthetase; Region: argS; TIGR00456
1248725000962	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1248725000963	active site
1248725000964	HIGH motif; other site
1248725000965	KMSK motif region; other site
1248725000966	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1248725000967	tRNA binding surface [nucleotide binding]; other site
1248725000968	anticodon binding site; other site
1248725000969	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1248725000970	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1248725000971	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1248725000972	catalytic site [active]
1248725000973	G-X2-G-X-G-K; other site
1248725000974	nuclease NucT; Provisional; Region: PRK13912
1248725000975	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
1248725000976	putative active site [active]
1248725000977	catalytic site [active]
1248725000978	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725000979	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1248725000980	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1248725000981	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1248725000982	ligand binding site; other site
1248725000983	tetramer interface; other site
1248725000984	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
1248725000985	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
1248725000986	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1248725000987	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1248725000988	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1248725000989	NAD synthetase; Provisional; Region: PRK13980
1248725000990	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1248725000991	homodimer interface [polypeptide binding]; other site
1248725000992	NAD binding pocket [chemical binding]; other site
1248725000993	ATP binding pocket [chemical binding]; other site
1248725000994	Mg binding site [ion binding]; other site
1248725000995	active-site loop [active]
1248725000996	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1248725000997	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1248725000998	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1248725000999	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1248725001000	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1248725001001	Switch I; other site
1248725001002	Switch II; other site
1248725001003	cell division topological specificity factor MinE; Region: minE; TIGR01215
1248725001004	DNA protecting protein DprA; Region: dprA; TIGR00732
1248725001005	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1248725001006	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1248725001007	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725001008	chlorohydrolase; Provisional; Region: PRK07213
1248725001009	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1248725001010	catalytic residue [active]
1248725001011	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1248725001012	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1248725001013	active site
1248725001014	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1248725001015	DHH family; Region: DHH; pfam01368
1248725001016	DHHA1 domain; Region: DHHA1; pfam02272
1248725001017	CTP synthetase; Validated; Region: pyrG; PRK05380
1248725001018	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1248725001019	Catalytic site [active]
1248725001020	active site
1248725001021	UTP binding site [chemical binding]; other site
1248725001022	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1248725001023	active site
1248725001024	putative oxyanion hole; other site
1248725001025	catalytic triad [active]
1248725001026	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1248725001027	active site
1248725001028	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
1248725001029	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1248725001030	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1248725001031	flagellar motor switch protein FliG; Region: fliG; TIGR00207
1248725001032	FliG C-terminal domain; Region: FliG_C; pfam01706
1248725001033	flagellar assembly protein H; Validated; Region: fliH; PRK06669
1248725001034	Flagellar assembly protein FliH; Region: FliH; pfam02108
1248725001035	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
1248725001036	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1248725001037	TPP-binding site; other site
1248725001038	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1248725001039	PYR/PP interface [polypeptide binding]; other site
1248725001040	dimer interface [polypeptide binding]; other site
1248725001041	TPP binding site [chemical binding]; other site
1248725001042	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1248725001043	GTP-binding protein LepA; Provisional; Region: PRK05433
1248725001044	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1248725001045	G1 box; other site
1248725001046	putative GEF interaction site [polypeptide binding]; other site
1248725001047	GTP/Mg2+ binding site [chemical binding]; other site
1248725001048	Switch I region; other site
1248725001049	G2 box; other site
1248725001050	G3 box; other site
1248725001051	Switch II region; other site
1248725001052	G4 box; other site
1248725001053	G5 box; other site
1248725001054	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1248725001055	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1248725001056	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1248725001057	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1248725001058	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1248725001059	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1248725001060	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1248725001061	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1248725001062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725001063	putative substrate translocation pore; other site
1248725001064	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1248725001065	TspO/MBR family; Region: TspO_MBR; cl01379
1248725001066	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1248725001067	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1248725001068	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
1248725001069	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1248725001070	transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232
1248725001071	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1248725001072	TPP-binding site [chemical binding]; other site
1248725001073	dimer interface [polypeptide binding]; other site
1248725001074	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1248725001075	PYR/PP interface [polypeptide binding]; other site
1248725001076	dimer interface [polypeptide binding]; other site
1248725001077	TPP binding site [chemical binding]; other site
1248725001078	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1248725001079	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1248725001080	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
1248725001081	active site
1248725001082	Riboflavin kinase; Region: Flavokinase; smart00904
1248725001083	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1248725001084	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1248725001085	RNA binding surface [nucleotide binding]; other site
1248725001086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725001087	S-adenosylmethionine binding site [chemical binding]; other site
1248725001088	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1248725001089	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1248725001090	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1248725001091	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725001092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1248725001093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1248725001094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725001095	Walker A/P-loop; other site
1248725001096	ATP binding site [chemical binding]; other site
1248725001097	Q-loop/lid; other site
1248725001098	ABC transporter signature motif; other site
1248725001099	Walker B; other site
1248725001100	D-loop; other site
1248725001101	H-loop/switch region; other site
1248725001102	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
1248725001103	Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787
1248725001104	Restriction endonuclease; Region: Mrr_cat; pfam04471
1248725001105	Predicted ATPases [General function prediction only]; Region: COG1106
1248725001106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725001107	Walker A/P-loop; other site
1248725001108	ATP binding site [chemical binding]; other site
1248725001109	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1248725001110	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
1248725001111	active site
1248725001112	Zn binding site [ion binding]; other site
1248725001113	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1248725001114	metal-binding site [ion binding]
1248725001115	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1248725001116	metal-binding site [ion binding]
1248725001117	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1248725001118	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1248725001119	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1248725001120	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1248725001121	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1248725001122	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1248725001123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725001124	Walker A motif; other site
1248725001125	ATP binding site [chemical binding]; other site
1248725001126	Walker B motif; other site
1248725001127	arginine finger; other site
1248725001128	Peptidase family M41; Region: Peptidase_M41; pfam01434
1248725001129	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1248725001130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1248725001131	S-adenosylmethionine binding site [chemical binding]; other site
1248725001132	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1248725001133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725001134	active site
1248725001135	phosphorylation site [posttranslational modification]
1248725001136	intermolecular recognition site; other site
1248725001137	dimerization interface [polypeptide binding]; other site
1248725001138	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001139	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1248725001140	16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138
1248725001141	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1248725001142	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1248725001143	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1248725001144	sec-independent translocase; Provisional; Region: PRK04098
1248725001145	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1248725001146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725001147	Walker A motif; other site
1248725001148	ATP binding site [chemical binding]; other site
1248725001149	Walker B motif; other site
1248725001150	arginine finger; other site
1248725001151	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1248725001152	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1248725001153	oligomerization interface [polypeptide binding]; other site
1248725001154	active site
1248725001155	metal binding site [ion binding]; metal-binding site
1248725001156	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001157	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001158	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1248725001159	septum formation inhibitor; Reviewed; Region: minC; PRK00556
1248725001160	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1248725001161	UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325
1248725001162	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1248725001163	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1248725001164	homoserine kinase; Region: thrB; TIGR00191
1248725001165	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1248725001166	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
1248725001167	putative RNA binding cleft [nucleotide binding]; other site
1248725001168	translation initiation factor IF-2; Region: IF-2; TIGR00487
1248725001169	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1248725001170	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1248725001171	G1 box; other site
1248725001172	putative GEF interaction site [polypeptide binding]; other site
1248725001173	GTP/Mg2+ binding site [chemical binding]; other site
1248725001174	Switch I region; other site
1248725001175	G2 box; other site
1248725001176	G3 box; other site
1248725001177	Switch II region; other site
1248725001178	G4 box; other site
1248725001179	G5 box; other site
1248725001180	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1248725001181	Translation-initiation factor 2; Region: IF-2; pfam11987
1248725001182	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1248725001183	Ribosome-binding factor A; Region: RBFA; cl00542
1248725001184	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
1248725001185	Sm and related proteins; Region: Sm_like; cl00259
1248725001186	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1248725001187	putative oligomer interface [polypeptide binding]; other site
1248725001188	putative RNA binding site [nucleotide binding]; other site
1248725001189	acetyl-CoA synthetase; Provisional; Region: PRK00174
1248725001190	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1248725001191	active site
1248725001192	CoA binding site [chemical binding]; other site
1248725001193	acyl-activating enzyme (AAE) consensus motif; other site
1248725001194	AMP binding site [chemical binding]; other site
1248725001195	acetate binding site [chemical binding]; other site
1248725001196	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1248725001197	putative active site [active]
1248725001198	putative metal binding site [ion binding]; other site
1248725001199	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1248725001200	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1248725001201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725001202	active site
1248725001203	intermolecular recognition site; other site
1248725001204	dimerization interface [polypeptide binding]; other site
1248725001205	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1248725001206	DNA binding site [nucleotide binding]
1248725001207	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1248725001208	DHH family; Region: DHH; pfam01368
1248725001209	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1248725001210	FHIPEP family; Region: FHIPEP; pfam00771
1248725001211	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1248725001212	16S/18S rRNA binding site [nucleotide binding]; other site
1248725001213	S13e-L30e interaction site [polypeptide binding]; other site
1248725001214	25S rRNA binding site [nucleotide binding]; other site
1248725001215	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1248725001216	O-Antigen ligase; Region: Wzy_C; pfam04932
1248725001217	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1248725001218	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1248725001219	trimer interface [polypeptide binding]; other site
1248725001220	active site
1248725001221	dimer interface [polypeptide binding]; other site
1248725001222	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1248725001223	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1248725001224	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1248725001225	active site
1248725001226	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1248725001227	catalytic center binding site [active]
1248725001228	ATP binding site [chemical binding]; other site
1248725001229	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
1248725001230	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1248725001231	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1248725001232	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1248725001233	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1248725001234	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1248725001235	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1248725001236	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1248725001237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1248725001238	DNA binding residues [nucleotide binding]
1248725001239	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1248725001240	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1248725001241	flagellar motor switch protein FliY; Validated; Region: PRK08432
1248725001242	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1248725001243	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1248725001244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
1248725001245	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1248725001246	metal binding site 2 [ion binding]; metal-binding site
1248725001247	putative DNA binding helix; other site
1248725001248	metal binding site 1 [ion binding]; metal-binding site
1248725001249	dimer interface [polypeptide binding]; other site
1248725001250	structural Zn2+ binding site [ion binding]; other site
1248725001251	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
1248725001252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725001253	Walker A motif; other site
1248725001254	ATP binding site [chemical binding]; other site
1248725001255	Walker B motif; other site
1248725001256	arginine finger; other site
1248725001257	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1248725001258	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1248725001259	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1248725001260	DNA binding residues [nucleotide binding]
1248725001261	putative dimer interface [polypeptide binding]; other site
1248725001262	chaperone protein DnaJ; Provisional; Region: PRK14299
1248725001263	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1248725001264	HSP70 interaction site [polypeptide binding]; other site
1248725001265	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1248725001266	substrate binding site [polypeptide binding]; other site
1248725001267	dimer interface [polypeptide binding]; other site
1248725001268	5'-3' exonuclease; Provisional; Region: PRK14976
1248725001269	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1248725001270	putative active site [active]
1248725001271	Helix-hairpin-helix class 2 (Pol1 family) motifs; Region: HhH2; smart00279
1248725001272	DNA binding site [nucleotide binding]
1248725001273	metal binding site [ion binding]; metal-binding site
1248725001274	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1248725001275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725001276	active site
1248725001277	dimerization interface [polypeptide binding]; other site
1248725001278	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1248725001279	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1248725001280	substrate binding site; other site
1248725001281	dimer interface; other site
1248725001282	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1248725001283	homotrimer interaction site [polypeptide binding]; other site
1248725001284	zinc binding site [ion binding]; other site
1248725001285	CDP-binding sites; other site
1248725001286	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1248725001287	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1248725001288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1248725001289	protein binding site [polypeptide binding]; other site
1248725001290	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1248725001291	protein binding site [polypeptide binding]; other site
1248725001292	S-methylmethionine transporter; Provisional; Region: PRK11387
1248725001293	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1248725001294	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
1248725001295	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
1248725001296	putative NAD(P) binding site [chemical binding]; other site
1248725001297	active site
1248725001298	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1248725001299	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1248725001300	dimer interface [polypeptide binding]; other site
1248725001301	active site
1248725001302	catalytic residue [active]
1248725001303	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1248725001304	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1248725001305	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1248725001306	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
1248725001307	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1248725001308	quinone interaction residues [chemical binding]; other site
1248725001309	active site
1248725001310	catalytic residues [active]
1248725001311	FMN binding site [chemical binding]; other site
1248725001312	substrate binding site [chemical binding]; other site
1248725001313	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
1248725001314	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1248725001315	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1248725001316	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1248725001317	putative domain interface [polypeptide binding]; other site
1248725001318	putative active site [active]
1248725001319	catalytic site [active]
1248725001320	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1248725001321	putative active site [active]
1248725001322	putative domain interface [polypeptide binding]; other site
1248725001323	catalytic site [active]
1248725001324	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1248725001325	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725001326	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1248725001327	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725001328	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1248725001329	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1248725001330	ATP binding site [chemical binding]; other site
1248725001331	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1248725001332	putative Mg++ binding site [ion binding]; other site
1248725001333	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1248725001334	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1248725001335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
1248725001336	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1248725001337	putative metal binding site [ion binding]; other site
1248725001338	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1248725001339	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1248725001340	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
1248725001341	active site
1248725001342	Zn binding site [ion binding]; other site
1248725001343	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1248725001344	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1248725001345	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001346	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1248725001347	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1248725001348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725001349	dimer interface [polypeptide binding]; other site
1248725001350	conserved gate region; other site
1248725001351	ABC-ATPase subunit interface; other site
1248725001352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1248725001353	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1248725001354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725001355	Walker A/P-loop; other site
1248725001356	ATP binding site [chemical binding]; other site
1248725001357	Q-loop/lid; other site
1248725001358	ABC transporter signature motif; other site
1248725001359	Walker B; other site
1248725001360	D-loop; other site
1248725001361	H-loop/switch region; other site
1248725001362	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1248725001363	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1248725001364	active site
1248725001365	HIGH motif; other site
1248725001366	nucleotide binding site [chemical binding]; other site
1248725001367	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1248725001368	active site
1248725001369	KMSKS motif; other site
1248725001370	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001371	Helix-turn-helix domain; Region: HTH_17; pfam12728
1248725001372	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1248725001373	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725001374	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
1248725001375	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1248725001376	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1248725001377	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
1248725001378	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1248725001379	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1248725001380	G1 box; other site
1248725001381	putative GEF interaction site [polypeptide binding]; other site
1248725001382	GTP/Mg2+ binding site [chemical binding]; other site
1248725001383	Switch I region; other site
1248725001384	G2 box; other site
1248725001385	G3 box; other site
1248725001386	Switch II region; other site
1248725001387	G4 box; other site
1248725001388	G5 box; other site
1248725001389	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1248725001390	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1248725001391	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1248725001392	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1248725001393	GIY-YIG motif/motif A; other site
1248725001394	active site
1248725001395	catalytic site [active]
1248725001396	metal binding site [ion binding]; metal-binding site
1248725001397	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1248725001398	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1248725001399	putative heme binding pocket [chemical binding]; other site
1248725001400	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725001401	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725001402	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
1248725001403	Cation transport protein; Region: TrkH; cl17365
1248725001404	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1248725001405	TrkA-N domain; Region: TrkA_N; pfam02254
1248725001406	TrkA-C domain; Region: TrkA_C; pfam02080
1248725001407	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1248725001408	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
1248725001409	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1248725001410	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1248725001411	Mg++ binding site [ion binding]; other site
1248725001412	putative catalytic motif [active]
1248725001413	putative substrate binding site [chemical binding]; other site
1248725001414	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
1248725001415	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1248725001416	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1248725001417	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1248725001418	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1248725001419	active site
1248725001420	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1248725001421	Na2 binding site [ion binding]; other site
1248725001422	putative substrate binding site 1 [chemical binding]; other site
1248725001423	Na binding site 1 [ion binding]; other site
1248725001424	putative substrate binding site 2 [chemical binding]; other site
1248725001425	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1248725001426	Na2 binding site [ion binding]; other site
1248725001427	putative substrate binding site 1 [chemical binding]; other site
1248725001428	Na binding site 1 [ion binding]; other site
1248725001429	putative substrate binding site 2 [chemical binding]; other site
1248725001430	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1248725001431	dimerization interface [polypeptide binding]; other site
1248725001432	substrate binding site [chemical binding]; other site
1248725001433	active site
1248725001434	calcium binding site [ion binding]; other site
1248725001435	DNA polymerase III, beta subunit; Region: dnan; TIGR00663
1248725001436	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1248725001437	putative DNA binding surface [nucleotide binding]; other site
1248725001438	dimer interface [polypeptide binding]; other site
1248725001439	beta-clamp/translesion DNA polymerase binding surface; other site
1248725001440	beta-clamp/clamp loader binding surface; other site
1248725001441	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1248725001442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725001443	Mg2+ binding site [ion binding]; other site
1248725001444	G-X-G motif; other site
1248725001445	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1248725001446	anchoring element; other site
1248725001447	dimer interface [polypeptide binding]; other site
1248725001448	ATP binding site [chemical binding]; other site
1248725001449	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1248725001450	active site
1248725001451	putative metal-binding site [ion binding]; other site
1248725001452	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1248725001453	R.Pab1 restriction endonuclease; Region: RE_R_Pab1; pfam09522
1248725001454	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1248725001455	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725001456	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1248725001457	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1248725001458	dimer interface [polypeptide binding]; other site
1248725001459	ADP-ribose binding site [chemical binding]; other site
1248725001460	active site
1248725001461	nudix motif; other site
1248725001462	metal binding site [ion binding]; metal-binding site
1248725001463	FAD binding domain; Region: FAD_binding_4; pfam01565
1248725001464	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1248725001465	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
1248725001466	dihydrodipicolinate reductase; Region: dapB; TIGR00036
1248725001467	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1248725001468	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1248725001469	glutamine synthetase, type I; Region: GlnA; TIGR00653
1248725001470	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1248725001471	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1248725001472	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725001473	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725001474	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725001475	Uncharacterized conserved protein [Function unknown]; Region: COG3586
1248725001476	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1248725001477	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1248725001478	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
1248725001479	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1248725001480	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1248725001481	active site
1248725001482	catalytic residues [active]
1248725001483	DNA binding site [nucleotide binding]
1248725001484	Int/Topo IB signature motif; other site
1248725001485	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1248725001486	Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846
1248725001487	Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846
1248725001488	ParA-like protein; Provisional; Region: PHA02518
1248725001489	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1248725001490	P-loop; other site
1248725001491	Magnesium ion binding site [ion binding]; other site
1248725001492	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1248725001493	V-type ATP synthase subunit I; Validated; Region: PRK05771
1248725001494	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1248725001495	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761
1248725001496	DNA binding residues [nucleotide binding]
1248725001497	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1248725001498	catalytic residues [active]
1248725001499	catalytic nucleophile [active]
1248725001500	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1248725001501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1248725001502	Probable transposase; Region: OrfB_IS605; pfam01385
1248725001503	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1248725001504	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1248725001505	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1248725001506	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1248725001507	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1248725001508	VirB7 interaction site; other site
1248725001509	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1248725001510	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1248725001511	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1248725001512	Walker A motif; other site
1248725001513	hexamer interface [polypeptide binding]; other site
1248725001514	ATP binding site [chemical binding]; other site
1248725001515	Walker B motif; other site
1248725001516	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1248725001517	Walker A motif; other site
1248725001518	ATP binding site [chemical binding]; other site
1248725001519	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1248725001520	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1248725001521	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1248725001522	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725001523	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1248725001524	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1248725001525	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1248725001526	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1248725001527	nucleotide binding region [chemical binding]; other site
1248725001528	ATP-binding site [chemical binding]; other site
1248725001529	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1248725001530	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1248725001531	Domain of unknown function DUF87; Region: DUF87; pfam01935
1248725001532	TrbC/VIRB2 family; Region: TrbC; pfam04956
1248725001533	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725001534	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725001535	Uncharacterized conserved protein [Function unknown]; Region: COG3586
1248725001536	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1248725001537	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1248725001538	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1248725001539	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1248725001540	active site
1248725001541	HslU subunit interaction site [polypeptide binding]; other site
1248725001542	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1248725001543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725001544	Walker A motif; other site
1248725001545	ATP binding site [chemical binding]; other site
1248725001546	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1248725001547	Walker B motif; other site
1248725001548	arginine finger; other site
1248725001549	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1248725001550	GTPase [General function prediction only]; Region: Era; COG1159
1248725001551	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1248725001552	G1 box; other site
1248725001553	GTP/Mg2+ binding site [chemical binding]; other site
1248725001554	Switch I region; other site
1248725001555	G2 box; other site
1248725001556	Switch II region; other site
1248725001557	G3 box; other site
1248725001558	G4 box; other site
1248725001559	G5 box; other site
1248725001560	KH domain; Region: KH_2; pfam07650
1248725001561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1248725001562	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725001563	Sel1-like repeats; Region: SEL1; smart00671
1248725001564	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1248725001565	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1248725001566	Walker A motif; other site
1248725001567	ATP binding site [chemical binding]; other site
1248725001568	Walker B motif; other site
1248725001569	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1248725001570	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1248725001571	ATP binding site [chemical binding]; other site
1248725001572	Walker A motif; other site
1248725001573	hexamer interface [polypeptide binding]; other site
1248725001574	Walker B motif; other site
1248725001575	CagZ; Region: CagZ; pfam09053
1248725001576	DC-EC Repeat; Region: CagY_M; pfam07337
1248725001577	DC-EC Repeat; Region: CagY_M; pfam07337
1248725001578	DC-EC Repeat; Region: CagY_M; pfam07337
1248725001579	DC-EC Repeat; Region: CagY_M; pfam07337
1248725001580	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1248725001581	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1248725001582	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1248725001583	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1248725001584	VirB7 interaction site; other site
1248725001585	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
1248725001586	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
1248725001587	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1248725001588	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1248725001589	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1248725001590	CagA exotoxin; Region: CagA; pfam03507
1248725001591	CagA exotoxin; Region: CagA; pfam03507
1248725001592	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1248725001593	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1248725001594	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1248725001595	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1248725001596	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1248725001597	RNA binding site [nucleotide binding]; other site
1248725001598	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1248725001599	multimer interface [polypeptide binding]; other site
1248725001600	Walker A motif; other site
1248725001601	ATP binding site [chemical binding]; other site
1248725001602	Walker B motif; other site
1248725001603	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
1248725001604	Predicted methyltransferases [General function prediction only]; Region: COG0313
1248725001605	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1248725001606	putative SAM binding site [chemical binding]; other site
1248725001607	putative homodimer interface [polypeptide binding]; other site
1248725001608	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1248725001609	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1248725001610	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1248725001611	acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Region: accA; TIGR00513
1248725001612	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1248725001613	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439
1248725001614	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1248725001615	dimer interface [polypeptide binding]; other site
1248725001616	active site
1248725001617	acyl carrier protein; Provisional; Region: acpP; PRK00982
1248725001618	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1248725001619	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1248725001620	NAD(P) binding site [chemical binding]; other site
1248725001621	active site
1248725001622	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1248725001623	Predicted membrane protein [Function unknown]; Region: COG3059
1248725001624	diaminopimelate epimerase; Region: DapF; TIGR00652
1248725001625	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1248725001626	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1248725001627	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1248725001628	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1248725001629	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725001630	FeS/SAM binding site; other site
1248725001631	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1248725001632	GTP-binding protein YchF; Reviewed; Region: PRK09601
1248725001633	YchF GTPase; Region: YchF; cd01900
1248725001634	G1 box; other site
1248725001635	GTP/Mg2+ binding site [chemical binding]; other site
1248725001636	Switch I region; other site
1248725001637	G2 box; other site
1248725001638	Switch II region; other site
1248725001639	G3 box; other site
1248725001640	G4 box; other site
1248725001641	G5 box; other site
1248725001642	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1248725001643	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1248725001644	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1248725001645	interface (dimer of trimers) [polypeptide binding]; other site
1248725001646	Substrate-binding/catalytic site; other site
1248725001647	Zn-binding sites [ion binding]; other site
1248725001648	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1248725001649	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1248725001650	active site
1248725001651	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1248725001652	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
1248725001653	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1248725001654	Peptidase family M50; Region: Peptidase_M50; pfam02163
1248725001655	active site
1248725001656	putative substrate binding region [chemical binding]; other site
1248725001657	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1248725001658	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1248725001659	Catalytic site [active]
1248725001660	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1248725001661	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191
1248725001662	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1248725001663	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1248725001664	homodimer interface [polypeptide binding]; other site
1248725001665	NADP binding site [chemical binding]; other site
1248725001666	substrate binding site [chemical binding]; other site
1248725001667	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1248725001668	Sulfatase; Region: Sulfatase; pfam00884
1248725001669	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1248725001670	BNR repeat-like domain; Region: BNR_2; pfam13088
1248725001671	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1248725001672	active site
1248725001673	substrate binding pocket [chemical binding]; other site
1248725001674	dimer interface [polypeptide binding]; other site
1248725001675	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1248725001676	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
1248725001677	flagellar motor switch protein; Validated; Region: PRK08433
1248725001678	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1248725001679	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1248725001680	minor groove reading motif; other site
1248725001681	helix-hairpin-helix signature motif; other site
1248725001682	substrate binding pocket [chemical binding]; other site
1248725001683	active site
1248725001684	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1248725001685	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1248725001686	Protein of unknown function; Region: DUF3971; pfam13116
1248725001687	AsmA-like C-terminal region; Region: AsmA_1; pfam13109
1248725001688	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1248725001689	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1248725001690	dimerization interface [polypeptide binding]; other site
1248725001691	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
1248725001692	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1248725001693	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
1248725001694	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1248725001695	dimer interface [polypeptide binding]; other site
1248725001696	PYR/PP interface [polypeptide binding]; other site
1248725001697	TPP binding site [chemical binding]; other site
1248725001698	substrate binding site [chemical binding]; other site
1248725001699	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
1248725001700	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1248725001701	TPP-binding site [chemical binding]; other site
1248725001702	2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441
1248725001703	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
1248725001704	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
1248725001705	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
1248725001706	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
1248725001707	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
1248725001708	tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303
1248725001709	Transglycosylase; Region: Transgly; pfam00912
1248725001710	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1248725001711	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1248725001712	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1248725001713	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1248725001714	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1248725001715	catalytic residue [active]
1248725001716	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1248725001717	dimer interface [polypeptide binding]; other site
1248725001718	putative CheW interface [polypeptide binding]; other site
1248725001719	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1248725001720	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1248725001721	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1248725001722	Walker A/P-loop; other site
1248725001723	ATP binding site [chemical binding]; other site
1248725001724	Q-loop/lid; other site
1248725001725	ABC transporter signature motif; other site
1248725001726	Walker B; other site
1248725001727	D-loop; other site
1248725001728	H-loop/switch region; other site
1248725001729	flagellin A; Reviewed; Region: PRK12584
1248725001730	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1248725001731	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1248725001732	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1248725001733	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1248725001734	3-methyladenine DNA glycosylase; Provisional; Region: PRK13913
1248725001735	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1248725001736	minor groove reading motif; other site
1248725001737	helix-hairpin-helix signature motif; other site
1248725001738	active site
1248725001739	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1248725001740	substrate binding site [chemical binding]; other site
1248725001741	active site
1248725001742	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1248725001743	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1248725001744	HlyD family secretion protein; Region: HlyD_3; pfam13437
1248725001745	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1248725001746	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001747	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1248725001748	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725001749	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725001750	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725001751	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725001752	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1248725001753	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725001754	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1248725001755	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1248725001756	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1248725001757	nucleotide binding pocket [chemical binding]; other site
1248725001758	K-X-D-G motif; other site
1248725001759	catalytic site [active]
1248725001760	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1248725001761	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1248725001762	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1248725001763	Dimer interface [polypeptide binding]; other site
1248725001764	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1248725001765	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1248725001766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725001767	active site
1248725001768	phosphorylation site [posttranslational modification]
1248725001769	intermolecular recognition site; other site
1248725001770	dimerization interface [polypeptide binding]; other site
1248725001771	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1248725001772	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1248725001773	dimer interface [polypeptide binding]; other site
1248725001774	anticodon binding site; other site
1248725001775	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1248725001776	homodimer interface [polypeptide binding]; other site
1248725001777	motif 1; other site
1248725001778	active site
1248725001779	motif 2; other site
1248725001780	GAD domain; Region: GAD; pfam02938
1248725001781	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1248725001782	active site
1248725001783	motif 3; other site
1248725001784	adenylate kinase; Reviewed; Region: adk; PRK00279
1248725001785	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1248725001786	AMP-binding site [chemical binding]; other site
1248725001787	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1248725001788	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1248725001789	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
1248725001790	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1248725001791	Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306
1248725001792	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1248725001793	dimer interface [polypeptide binding]; other site
1248725001794	substrate binding site [chemical binding]; other site
1248725001795	metal binding sites [ion binding]; metal-binding site
1248725001796	MutS2 family protein; Region: mutS2; TIGR01069
1248725001797	ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534
1248725001798	Walker A/P-loop; other site
1248725001799	ATP binding site [chemical binding]; other site
1248725001800	Q-loop/lid; other site
1248725001801	ABC transporter signature motif; other site
1248725001802	Walker B; other site
1248725001803	D-loop; other site
1248725001804	H-loop/switch region; other site
1248725001805	Smr domain; Region: Smr; pfam01713
1248725001806	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
1248725001807	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1248725001808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1248725001809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1248725001810	hypothetical protein; Provisional; Region: PRK05839
1248725001811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1248725001812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725001813	homodimer interface [polypeptide binding]; other site
1248725001814	catalytic residue [active]
1248725001815	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1248725001816	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1248725001817	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1248725001818	Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
1248725001819	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1248725001820	putative trimer interface [polypeptide binding]; other site
1248725001821	putative CoA binding site [chemical binding]; other site
1248725001822	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725001823	Sel1-like repeats; Region: SEL1; smart00671
1248725001824	Sel1-like repeats; Region: SEL1; smart00671
1248725001825	Sel1 repeat; Region: Sel1; cl02723
1248725001826	Sel1-like repeats; Region: SEL1; smart00671
1248725001827	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725001828	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725001829	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725001830	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1248725001831	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
1248725001832	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1248725001833	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1248725001834	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1248725001835	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
1248725001836	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1248725001837	nickel binding site [ion binding]; other site
1248725001838	putative substrate-binding site; other site
1248725001839	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001840	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1248725001841	Ligand Binding Site [chemical binding]; other site
1248725001842	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1248725001843	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1248725001844	active site
1248725001845	NTP binding site [chemical binding]; other site
1248725001846	metal binding triad [ion binding]; metal-binding site
1248725001847	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1248725001848	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1248725001849	dimer interface [polypeptide binding]; other site
1248725001850	FMN binding site [chemical binding]; other site
1248725001851	glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410
1248725001852	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1248725001853	active site
1248725001854	HIGH motif; other site
1248725001855	nucleotide binding site [chemical binding]; other site
1248725001856	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1248725001857	active site
1248725001858	KMSKS motif; other site
1248725001859	YGGT family; Region: YGGT; pfam02325
1248725001860	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1248725001861	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1248725001862	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1248725001863	catalytic residue [active]
1248725001864	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1248725001865	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1248725001866	active site
1248725001867	tetramer interface; other site
1248725001868	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1248725001869	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1248725001870	hinge; other site
1248725001871	active site
1248725001872	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1248725001873	Aspartase; Region: Aspartase; cd01357
1248725001874	active sites [active]
1248725001875	tetramer interface [polypeptide binding]; other site
1248725001876	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1248725001877	ligand binding site [chemical binding]; other site
1248725001878	active site
1248725001879	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
1248725001880	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1248725001881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1248725001882	motif II; other site
1248725001883	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1248725001884	Ferritin-like domain; Region: Ferritin; pfam00210
1248725001885	ferroxidase diiron center [ion binding]; other site
1248725001886	hypothetical protein; Provisional; Region: PRK08444
1248725001887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725001888	FeS/SAM binding site; other site
1248725001889	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
1248725001890	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1248725001891	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1248725001892	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1248725001893	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1248725001894	Surface antigen; Region: Bac_surface_Ag; pfam01103
1248725001895	hypothetical protein; Provisional; Region: PRK08445
1248725001896	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725001897	FeS/SAM binding site; other site
1248725001898	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1248725001899	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1248725001900	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1248725001901	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1248725001902	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1248725001903	GatB domain; Region: GatB_Yqey; smart00845
1248725001904	SurA N-terminal domain; Region: SurA_N; pfam09312
1248725001905	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
1248725001906	Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439
1248725001907	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1248725001908	RNA/DNA hybrid binding site [nucleotide binding]; other site
1248725001909	active site
1248725001910	ribonuclease III; Reviewed; Region: rnc; PRK00102
1248725001911	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1248725001912	dimerization interface [polypeptide binding]; other site
1248725001913	active site
1248725001914	metal binding site [ion binding]; metal-binding site
1248725001915	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1248725001916	dsRNA binding site [nucleotide binding]; other site
1248725001917	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1248725001918	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1248725001919	Tetramer interface [polypeptide binding]; other site
1248725001920	active site
1248725001921	FMN-binding site [chemical binding]; other site
1248725001922	Protein of unknown function (DUF2603); Region: DUF2603; pfam10788
1248725001923	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
1248725001924	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725001925	FeS/SAM binding site; other site
1248725001926	HemN C-terminal domain; Region: HemN_C; pfam06969
1248725001927	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1248725001928	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1248725001929	Cysteine-rich domain; Region: CCG; pfam02754
1248725001930	Cysteine-rich domain; Region: CCG; pfam02754
1248725001931	Restriction endonuclease; Region: Mrr_cat; pfam04471
1248725001932	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1248725001933	ATP binding site [chemical binding]; other site
1248725001934	Predicted helicase [General function prediction only]; Region: COG4889
1248725001935	Predicted helicase [General function prediction only]; Region: COG4889
1248725001936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725001937	nucleotide binding region [chemical binding]; other site
1248725001938	ATP-binding site [chemical binding]; other site
1248725001939	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725001940	aspartate aminotransferase; Provisional; Region: PRK05764
1248725001941	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1248725001942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725001943	homodimer interface [polypeptide binding]; other site
1248725001944	catalytic residue [active]
1248725001945	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1248725001946	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1248725001947	active site
1248725001948	DNA binding site [nucleotide binding]
1248725001949	Int/Topo IB signature motif; other site
1248725001950	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1248725001951	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1248725001952	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1248725001953	DNA binding site [nucleotide binding]
1248725001954	active site
1248725001955	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1248725001956	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1248725001957	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1248725001958	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1248725001959	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
1248725001960	ATP cone domain; Region: ATP-cone; pfam03477
1248725001961	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1248725001962	active site
1248725001963	dimer interface [polypeptide binding]; other site
1248725001964	catalytic residues [active]
1248725001965	effector binding site; other site
1248725001966	R2 peptide binding site; other site
1248725001967	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359
1248725001968	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1248725001969	Substrate binding site; other site
1248725001970	Mg++ binding site; other site
1248725001971	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1248725001972	active site
1248725001973	substrate binding site [chemical binding]; other site
1248725001974	CoA binding site [chemical binding]; other site
1248725001975	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1248725001976	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1248725001977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1248725001978	N-terminal plug; other site
1248725001979	ligand-binding site [chemical binding]; other site
1248725001980	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1248725001981	ferrous iron transporter FeoB; Region: feoB; TIGR00437
1248725001982	G1 box; other site
1248725001983	GTP/Mg2+ binding site [chemical binding]; other site
1248725001984	Switch I region; other site
1248725001985	G2 box; other site
1248725001986	G3 box; other site
1248725001987	Switch II region; other site
1248725001988	G4 box; other site
1248725001989	G5 box; other site
1248725001990	Nucleoside recognition; Region: Gate; pfam07670
1248725001991	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1248725001992	Nucleoside recognition; Region: Gate; pfam07670
1248725001993	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1248725001994	active site
1248725001995	catalytic site [active]
1248725001996	substrate binding site [chemical binding]; other site
1248725001997	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
1248725001998	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725001999	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725002000	CfrBI restriction endonuclease; Region: RE_CfrBI; pfam09516
1248725002001	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB [DNA replication, recombination, and repair]; Region: COG3298
1248725002002	putative acyltransferase; Provisional; Region: PRK05790
1248725002003	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1248725002004	dimer interface [polypeptide binding]; other site
1248725002005	active site
1248725002006	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1248725002007	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1248725002008	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
1248725002009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
1248725002010	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1248725002011	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1248725002012	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1248725002013	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1248725002014	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1248725002015	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
1248725002016	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
1248725002017	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1248725002018	DNA gyrase subunit A; Validated; Region: PRK05560
1248725002019	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1248725002020	CAP-like domain; other site
1248725002021	active site
1248725002022	primary dimer interface [polypeptide binding]; other site
1248725002023	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002024	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002025	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002026	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002027	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002028	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1248725002029	Response regulator receiver domain; Region: Response_reg; pfam00072
1248725002030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725002031	active site
1248725002032	phosphorylation site [posttranslational modification]
1248725002033	intermolecular recognition site; other site
1248725002034	dimerization interface [polypeptide binding]; other site
1248725002035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725002036	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1248725002037	Walker A motif; other site
1248725002038	ATP binding site [chemical binding]; other site
1248725002039	Walker B motif; other site
1248725002040	arginine finger; other site
1248725002041	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1248725002042	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1248725002043	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1248725002044	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1248725002045	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002046	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1248725002047	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
1248725002048	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1248725002049	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1248725002050	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
1248725002051	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002052	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1248725002053	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1248725002054	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1248725002055	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1248725002056	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1248725002057	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1248725002058	Walker A/P-loop; other site
1248725002059	ATP binding site [chemical binding]; other site
1248725002060	Q-loop/lid; other site
1248725002061	ABC transporter signature motif; other site
1248725002062	Walker B; other site
1248725002063	D-loop; other site
1248725002064	H-loop/switch region; other site
1248725002065	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1248725002066	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1248725002067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725002068	Walker A motif; other site
1248725002069	ATP binding site [chemical binding]; other site
1248725002070	Walker B motif; other site
1248725002071	arginine finger; other site
1248725002072	Lysine efflux permease [General function prediction only]; Region: COG1279
1248725002073	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
1248725002074	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
1248725002075	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1248725002076	active site
1248725002077	homodimer interface [polypeptide binding]; other site
1248725002078	homotetramer interface [polypeptide binding]; other site
1248725002079	anaerobic c4-dicarboxylate membrane transporter family protein; Region: Dcu; TIGR00770
1248725002080	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1248725002081	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002082	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1248725002083	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1248725002084	FMN binding site [chemical binding]; other site
1248725002085	active site
1248725002086	catalytic residues [active]
1248725002087	substrate binding site [chemical binding]; other site
1248725002088	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1248725002089	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1248725002090	Ligand Binding Site [chemical binding]; other site
1248725002091	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337
1248725002092	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1248725002093	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
1248725002094	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1248725002095	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1248725002096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725002097	FeS/SAM binding site; other site
1248725002098	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1248725002099	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1248725002100	active site
1248725002101	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1248725002102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1248725002103	catalytic residue [active]
1248725002104	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1248725002105	tetramer interfaces [polypeptide binding]; other site
1248725002106	binuclear metal-binding site [ion binding]; other site
1248725002107	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1248725002108	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1248725002109	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1248725002110	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1248725002111	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1248725002112	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1248725002113	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1248725002114	nucleotide binding site/active site [active]
1248725002115	HIT family signature motif; other site
1248725002116	catalytic residue [active]
1248725002117	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1248725002118	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1248725002119	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1248725002120	active site
1248725002121	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1248725002122	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1248725002123	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1248725002124	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1248725002125	G1 box; other site
1248725002126	G1 box; other site
1248725002127	GTP/Mg2+ binding site [chemical binding]; other site
1248725002128	GTP/Mg2+ binding site [chemical binding]; other site
1248725002129	G2 box; other site
1248725002130	Switch I region; other site
1248725002131	G3 box; other site
1248725002132	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1248725002133	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1248725002134	active site
1248725002135	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1248725002136	Interdomain contacts; other site
1248725002137	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1248725002138	Cytokine receptor motif; other site
1248725002139	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1248725002140	Interdomain contacts; other site
1248725002141	Cytokine receptor motif; other site
1248725002142	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1248725002143	Interdomain contacts; other site
1248725002144	Cytokine receptor motif; other site
1248725002145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002146	S-adenosylmethionine binding site [chemical binding]; other site
1248725002147	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1248725002148	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1248725002149	Walker A/P-loop; other site
1248725002150	ATP binding site [chemical binding]; other site
1248725002151	Q-loop/lid; other site
1248725002152	ABC transporter signature motif; other site
1248725002153	Walker B; other site
1248725002154	D-loop; other site
1248725002155	H-loop/switch region; other site
1248725002156	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1248725002157	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1248725002158	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725002159	flagellar protein FlaG; Provisional; Region: PRK08452
1248725002160	flagellar capping protein; Validated; Region: fliD; PRK08453
1248725002161	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1248725002162	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1248725002163	flagellar biosynthetic protein FliS; Region: fliS; TIGR00208
1248725002164	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1248725002165	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1248725002166	putative ATP binding site [chemical binding]; other site
1248725002167	putative substrate interface [chemical binding]; other site
1248725002168	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
1248725002169	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1248725002170	putative active site; other site
1248725002171	catalytic triad [active]
1248725002172	putative dimer interface [polypeptide binding]; other site
1248725002173	Predicted permease [General function prediction only]; Region: COG2056
1248725002174	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1248725002175	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
1248725002176	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1248725002177	putative efflux protein, MATE family; Region: matE; TIGR00797
1248725002178	phosphodiesterase; Provisional; Region: PRK12704
1248725002179	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105
1248725002180	nucleic acid binding region [nucleotide binding]; other site
1248725002181	G-X-X-G motif; other site
1248725002182	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1248725002183	Zn2+ binding site [ion binding]; other site
1248725002184	Mg2+ binding site [ion binding]; other site
1248725002185	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1248725002186	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1248725002187	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1248725002188	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1248725002189	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1248725002190	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1248725002191	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725002192	FeS/SAM binding site; other site
1248725002193	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1248725002194	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1248725002195	GTP binding site; other site
1248725002196	flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328
1248725002197	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1248725002198	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1248725002199	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1248725002200	active site
1248725002201	metal binding site [ion binding]; metal-binding site
1248725002202	Nitronate monooxygenase; Region: NMO; pfam03060
1248725002203	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1248725002204	FMN binding site [chemical binding]; other site
1248725002205	substrate binding site [chemical binding]; other site
1248725002206	putative catalytic residue [active]
1248725002207	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1248725002208	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1248725002209	active site
1248725002210	HIGH motif; other site
1248725002211	dimer interface [polypeptide binding]; other site
1248725002212	KMSKS motif; other site
1248725002213	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1248725002214	RNA binding surface [nucleotide binding]; other site
1248725002215	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1248725002216	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1248725002217	Zn2+ binding site [ion binding]; other site
1248725002218	Mg2+ binding site [ion binding]; other site
1248725002219	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1248725002220	synthetase active site [active]
1248725002221	NTP binding site [chemical binding]; other site
1248725002222	metal binding site [ion binding]; metal-binding site
1248725002223	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1248725002224	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1248725002225	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1248725002226	putative nucleotide binding site [chemical binding]; other site
1248725002227	uridine monophosphate binding site [chemical binding]; other site
1248725002228	homohexameric interface [polypeptide binding]; other site
1248725002229	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
1248725002230	aconitate hydratase 2; Region: acnB; TIGR00117
1248725002231	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1248725002232	substrate binding site [chemical binding]; other site
1248725002233	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1248725002234	substrate binding site [chemical binding]; other site
1248725002235	ligand binding site [chemical binding]; other site
1248725002236	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
1248725002237	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725002238	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1248725002239	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1248725002240	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1248725002241	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1248725002242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725002243	nucleotide binding region [chemical binding]; other site
1248725002244	ATP-binding site [chemical binding]; other site
1248725002245	SEC-C motif; Region: SEC-C; pfam02810
1248725002246	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1248725002247	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1248725002248	FtsX-like permease family; Region: FtsX; pfam02687
1248725002249	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725002250	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1248725002251	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725002252	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1248725002253	metal-binding site [ion binding]
1248725002254	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1248725002255	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1248725002256	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1248725002257	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1248725002258	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1248725002259	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1248725002260	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1248725002261	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1248725002262	active site
1248725002263	catalytic residues [active]
1248725002264	metal binding site [ion binding]; metal-binding site
1248725002265	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1248725002266	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1248725002267	oligomer interface [polypeptide binding]; other site
1248725002268	active site residues [active]
1248725002269	trigger factor; Provisional; Region: tig; PRK01490
1248725002270	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1248725002271	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1248725002272	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002273	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
1248725002274	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528
1248725002275	trimer interface [polypeptide binding]; other site
1248725002276	putative active site [active]
1248725002277	dimer interface [polypeptide binding]; other site
1248725002278	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1248725002279	MPT binding site; other site
1248725002280	trimer interface [polypeptide binding]; other site
1248725002281	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1248725002282	MoaE homodimer interface [polypeptide binding]; other site
1248725002283	MoaD interaction [polypeptide binding]; other site
1248725002284	active site residues [active]
1248725002285	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1248725002286	MoaE interaction surface [polypeptide binding]; other site
1248725002287	MoeB interaction surface [polypeptide binding]; other site
1248725002288	thiocarboxylated glycine; other site
1248725002289	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1248725002290	dimerization interface [polypeptide binding]; other site
1248725002291	active site
1248725002292	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
1248725002293	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
1248725002294	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: ribB; TIGR00506
1248725002295	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1248725002296	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
1248725002297	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1248725002298	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1248725002299	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1248725002300	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1248725002301	N-terminal plug; other site
1248725002302	ligand-binding site [chemical binding]; other site
1248725002303	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
1248725002304	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455
1248725002305	RNA methyltransferase, RsmD family; Region: TIGR00095
1248725002306	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1248725002307	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1248725002308	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1248725002309	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
1248725002310	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1248725002311	ATP binding site [chemical binding]; other site
1248725002312	substrate interface [chemical binding]; other site
1248725002313	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1248725002314	flagellar motor protein MotA; Validated; Region: PRK08456
1248725002315	flagellar motor protein MotB; Reviewed; Region: motB; PRK08457
1248725002316	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1248725002317	ligand binding site [chemical binding]; other site
1248725002318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725002319	dimer interface [polypeptide binding]; other site
1248725002320	conserved gate region; other site
1248725002321	ABC-ATPase subunit interface; other site
1248725002322	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1248725002323	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1248725002324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725002325	Walker A/P-loop; other site
1248725002326	ATP binding site [chemical binding]; other site
1248725002327	Q-loop/lid; other site
1248725002328	ABC transporter signature motif; other site
1248725002329	Walker B; other site
1248725002330	D-loop; other site
1248725002331	H-loop/switch region; other site
1248725002332	excinuclease ABC, C subunit; Region: uvrC; TIGR00194
1248725002333	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1248725002334	GIY-YIG motif/motif A; other site
1248725002335	active site
1248725002336	catalytic site [active]
1248725002337	putative DNA binding site [nucleotide binding]; other site
1248725002338	metal binding site [ion binding]; metal-binding site
1248725002339	UvrB/uvrC motif; Region: UVR; pfam02151
1248725002340	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1248725002341	homoserine dehydrogenase; Provisional; Region: PRK06349
1248725002342	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1248725002343	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1248725002344	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
1248725002345	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1248725002346	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1248725002347	catalytic residues [active]
1248725002348	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1248725002349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1248725002350	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1248725002351	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1248725002352	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
1248725002353	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1248725002354	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1248725002355	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1248725002356	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1248725002357	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1248725002358	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1248725002359	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1248725002360	active site
1248725002361	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132
1248725002362	indole acetimide hydrolase; Validated; Region: PRK07488
1248725002363	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1248725002364	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1248725002365	CoA-binding site [chemical binding]; other site
1248725002366	spermidine synthase; Provisional; Region: speE; PRK00536
1248725002367	spermidine synthase; Provisional; Region: PRK00811
1248725002368	GTP-binding protein Der; Reviewed; Region: PRK00093
1248725002369	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1248725002370	G1 box; other site
1248725002371	GTP/Mg2+ binding site [chemical binding]; other site
1248725002372	Switch I region; other site
1248725002373	G2 box; other site
1248725002374	Switch II region; other site
1248725002375	G3 box; other site
1248725002376	G4 box; other site
1248725002377	G5 box; other site
1248725002378	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1248725002379	G1 box; other site
1248725002380	GTP/Mg2+ binding site [chemical binding]; other site
1248725002381	Switch I region; other site
1248725002382	G2 box; other site
1248725002383	G3 box; other site
1248725002384	Switch II region; other site
1248725002385	G4 box; other site
1248725002386	G5 box; other site
1248725002387	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1248725002388	IHF dimer interface [polypeptide binding]; other site
1248725002389	IHF - DNA interface [nucleotide binding]; other site
1248725002390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018
1248725002391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018
1248725002392	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
1248725002393	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
1248725002394	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1248725002395	NAD(P) binding site [chemical binding]; other site
1248725002396	homodimer interface [polypeptide binding]; other site
1248725002397	substrate binding site [chemical binding]; other site
1248725002398	active site
1248725002399	phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521
1248725002400	Flavoprotein; Region: Flavoprotein; pfam02441
1248725002401	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1248725002402	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1248725002403	thiamine phosphate binding site [chemical binding]; other site
1248725002404	active site
1248725002405	pyrophosphate binding site [ion binding]; other site
1248725002406	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1248725002407	dimer interface [polypeptide binding]; other site
1248725002408	substrate binding site [chemical binding]; other site
1248725002409	ATP binding site [chemical binding]; other site
1248725002410	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1248725002411	substrate binding site [chemical binding]; other site
1248725002412	multimerization interface [polypeptide binding]; other site
1248725002413	ATP binding site [chemical binding]; other site
1248725002414	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1248725002415	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1248725002416	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725002417	ATP binding site [chemical binding]; other site
1248725002418	putative Mg++ binding site [ion binding]; other site
1248725002419	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725002420	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1248725002421	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725002422	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1248725002423	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1248725002424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002425	S-adenosylmethionine binding site [chemical binding]; other site
1248725002426	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1248725002427	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1248725002428	active site
1248725002429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958
1248725002430	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1248725002431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725002432	Walker A/P-loop; other site
1248725002433	ATP binding site [chemical binding]; other site
1248725002434	Q-loop/lid; other site
1248725002435	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1248725002436	ABC transporter; Region: ABC_tran_2; pfam12848
1248725002437	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1248725002438	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1248725002439	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1248725002440	active site
1248725002441	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1248725002442	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1248725002443	dimer interface [polypeptide binding]; other site
1248725002444	active site
1248725002445	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1248725002446	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1248725002447	putative ribose interaction site [chemical binding]; other site
1248725002448	putative ADP binding site [chemical binding]; other site
1248725002449	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1248725002450	active site
1248725002451	nucleotide binding site [chemical binding]; other site
1248725002452	HIGH motif; other site
1248725002453	KMSKS motif; other site
1248725002454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1248725002455	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1248725002456	NAD(P) binding site [chemical binding]; other site
1248725002457	active site
1248725002458	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
1248725002459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1248725002460	active site
1248725002461	motif I; other site
1248725002462	motif II; other site
1248725002463	Uncharacterized conserved protein [Function unknown]; Region: COG2836
1248725002464	pantothenate kinase; Reviewed; Region: PRK13333
1248725002465	PQQ-like domain; Region: PQQ_2; pfam13360
1248725002466	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1248725002467	trimer interface [polypeptide binding]; other site
1248725002468	active site
1248725002469	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1248725002470	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1248725002471	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1248725002472	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1248725002473	lipid-A-disaccharide synthase; Region: lpxB; TIGR00215
1248725002474	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564
1248725002475	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1248725002476	flagellar hook protein FlgE; Validated; Region: flgE; PRK08425
1248725002477	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1248725002478	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1248725002479	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1248725002480	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1248725002481	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
1248725002482	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
1248725002483	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1248725002484	PhnA protein; Region: PhnA; pfam03831
1248725002485	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1248725002486	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1248725002487	tetramer interface [polypeptide binding]; other site
1248725002488	heme binding pocket [chemical binding]; other site
1248725002489	NADPH binding site [chemical binding]; other site
1248725002490	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1248725002491	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725002492	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725002493	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1248725002494	active site
1248725002495	putative DNA-binding cleft [nucleotide binding]; other site
1248725002496	dimer interface [polypeptide binding]; other site
1248725002497	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1248725002498	LabA_like proteins; Region: LabA_like; cd06167
1248725002499	putative metal binding site [ion binding]; other site
1248725002500	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
1248725002501	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
1248725002502	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
1248725002503	Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084
1248725002504	RuvA N terminal domain; Region: RuvA_N; pfam01330
1248725002505	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1248725002506	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1248725002507	MviN-like protein; Region: MVIN; pfam03023
1248725002508	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1248725002509	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1248725002510	active site
1248725002511	HIGH motif; other site
1248725002512	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1248725002513	KMSKS motif; other site
1248725002514	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1248725002515	tRNA binding surface [nucleotide binding]; other site
1248725002516	anticodon binding site; other site
1248725002517	Vacuolating cyotoxin; Region: VacA; pfam02691
1248725002518	Vacuolating cyotoxin; Region: VacA; pfam02691
1248725002519	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1248725002520	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1248725002521	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1248725002522	Walker A/P-loop; other site
1248725002523	ATP binding site [chemical binding]; other site
1248725002524	Q-loop/lid; other site
1248725002525	ABC transporter signature motif; other site
1248725002526	Walker B; other site
1248725002527	D-loop; other site
1248725002528	H-loop/switch region; other site
1248725002529	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1248725002530	ABC-ATPase subunit  interface; other site
1248725002531	dimer interface [polypeptide binding]; other site
1248725002532	putative PBP binding regions; other site
1248725002533	short chain dehydrogenase; Validated; Region: PRK06182
1248725002534	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1248725002535	NADP binding site [chemical binding]; other site
1248725002536	active site
1248725002537	steroid binding site; other site
1248725002538	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1248725002539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
1248725002540	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002541	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1248725002542	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1248725002543	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
1248725002544	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
1248725002545	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1248725002546	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1248725002547	Acetokinase family; Region: Acetate_kinase; cl17229
1248725002548	Acetokinase family; Region: Acetate_kinase; cl17229
1248725002549	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1248725002550	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1248725002551	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
1248725002552	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1248725002553	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842
1248725002554	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1248725002555	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1248725002556	flagellar hook protein FlgE; Validated; Region: flgE; PRK05841
1248725002557	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1248725002558	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
1248725002559	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1248725002560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002561	S-adenosylmethionine binding site [chemical binding]; other site
1248725002562	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1248725002563	Part of AAA domain; Region: AAA_19; pfam13245
1248725002564	Family description; Region: UvrD_C_2; pfam13538
1248725002565	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002566	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002567	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725002568	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1248725002569	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725002570	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725002571	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1248725002572	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1248725002573	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1248725002574	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1248725002575	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1248725002576	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1248725002577	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1248725002578	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1248725002579	IMP binding site; other site
1248725002580	dimer interface [polypeptide binding]; other site
1248725002581	interdomain contacts; other site
1248725002582	partial ornithine binding site; other site
1248725002583	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1248725002584	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1248725002585	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1248725002586	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1248725002587	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1248725002588	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725002589	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725002590	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1248725002591	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
1248725002592	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1248725002593	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002594	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1248725002595	active site 1 [active]
1248725002596	dimer interface [polypeptide binding]; other site
1248725002597	hexamer interface [polypeptide binding]; other site
1248725002598	active site 2 [active]
1248725002599	recombination protein RecR; Region: recR; TIGR00615
1248725002600	RecR protein; Region: RecR; pfam02132
1248725002601	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1248725002602	putative active site [active]
1248725002603	putative metal-binding site [ion binding]; other site
1248725002604	tetramer interface [polypeptide binding]; other site
1248725002605	tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094
1248725002606	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1248725002607	Permutation of conserved domain; other site
1248725002608	active site
1248725002609	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1248725002610	heat shock protein HtpX; Provisional; Region: PRK02870
1248725002611	GTP cyclohydrolase I; Region: folE; TIGR00063
1248725002612	GTP cyclohydrolase I; Provisional; Region: PLN03044
1248725002613	active site
1248725002614	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1248725002615	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1248725002616	substrate binding pocket [chemical binding]; other site
1248725002617	chain length determination region; other site
1248725002618	substrate-Mg2+ binding site; other site
1248725002619	catalytic residues [active]
1248725002620	aspartate-rich region 1; other site
1248725002621	active site lid residues [active]
1248725002622	aspartate-rich region 2; other site
1248725002623	Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496
1248725002624	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1248725002625	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1248725002626	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1248725002627	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1248725002628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1248725002629	Coenzyme A binding pocket [chemical binding]; other site
1248725002630	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725002632	putative substrate translocation pore; other site
1248725002633	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725002634	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725002635	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725002636	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725002637	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725002638	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1248725002639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725002640	dimer interface [polypeptide binding]; other site
1248725002641	conserved gate region; other site
1248725002642	putative PBP binding loops; other site
1248725002643	ABC-ATPase subunit interface; other site
1248725002644	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1248725002645	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1248725002646	substrate binding pocket [chemical binding]; other site
1248725002647	membrane-bound complex binding site; other site
1248725002648	hinge residues; other site
1248725002649	alanine racemase; Region: alr; TIGR00492
1248725002650	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1248725002651	active site
1248725002652	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1248725002653	dimer interface [polypeptide binding]; other site
1248725002654	substrate binding site [chemical binding]; other site
1248725002655	catalytic residues [active]
1248725002656	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1248725002657	amino acid carrier protein; Region: agcS; TIGR00835
1248725002658	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1248725002659	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
1248725002660	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1248725002661	homotrimer interaction site [polypeptide binding]; other site
1248725002662	putative active site [active]
1248725002663	TRL-like protein family; Region: TRL; pfam13146
1248725002664	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1248725002665	Uncharacterized conserved protein [Function unknown]; Region: COG1576
1248725002666	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
1248725002667	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1248725002668	putative recombination protein RecO; Provisional; Region: PRK13908
1248725002669	competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199
1248725002670	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1248725002671	dimer interface [polypeptide binding]; other site
1248725002672	FMN binding site [chemical binding]; other site
1248725002673	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
1248725002674	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1248725002675	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1248725002676	active site
1248725002677	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1248725002678	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1248725002679	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1248725002680	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1248725002681	Putative zinc ribbon domain; Region: DUF164; pfam02591
1248725002682	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
1248725002683	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1248725002684	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1248725002685	dimer interface [polypeptide binding]; other site
1248725002686	motif 1; other site
1248725002687	active site
1248725002688	motif 2; other site
1248725002689	motif 3; other site
1248725002690	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1248725002691	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1248725002692	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1248725002693	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1248725002694	Dynamin family; Region: Dynamin_N; pfam00350
1248725002695	G1 box; other site
1248725002696	GTP/Mg2+ binding site [chemical binding]; other site
1248725002697	G2 box; other site
1248725002698	Switch I region; other site
1248725002699	G3 box; other site
1248725002700	Switch II region; other site
1248725002701	G4 box; other site
1248725002702	G5 box; other site
1248725002703	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1248725002704	G1 box; other site
1248725002705	GTP/Mg2+ binding site [chemical binding]; other site
1248725002706	G2 box; other site
1248725002707	Switch I region; other site
1248725002708	G3 box; other site
1248725002709	Switch II region; other site
1248725002710	G4 box; other site
1248725002711	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
1248725002712	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
1248725002713	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1248725002714	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1248725002715	Outer membrane efflux protein; Region: OEP; pfam02321
1248725002716	Outer membrane efflux protein; Region: OEP; pfam02321
1248725002717	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
1248725002718	phosphoglyceromutase; Provisional; Region: PRK05434
1248725002719	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
1248725002720	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
1248725002721	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1248725002722	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1248725002723	inhibitor-cofactor binding pocket; inhibition site
1248725002724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725002725	catalytic residue [active]
1248725002726	SurA N-terminal domain; Region: SurA_N_3; cl07813
1248725002727	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1248725002728	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1248725002729	cell division protein FtsA; Region: ftsA; TIGR01174
1248725002730	Cell division protein FtsA; Region: FtsA; smart00842
1248725002731	Cell division protein FtsA; Region: FtsA; pfam14450
1248725002732	cell division protein FtsZ; Validated; Region: PRK09330
1248725002733	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1248725002734	nucleotide binding site [chemical binding]; other site
1248725002735	SulA interaction site; other site
1248725002736	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1248725002737	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725002738	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725002739	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725002740	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725002741	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
1248725002742	DHH family; Region: DHH; pfam01368
1248725002743	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725002744	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
1248725002745	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1248725002746	active site
1248725002747	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1248725002748	catalytic residues [active]
1248725002749	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1248725002750	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1248725002751	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1248725002752	putative ADP-binding pocket [chemical binding]; other site
1248725002753	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1248725002754	active site 2 [active]
1248725002755	active site 1 [active]
1248725002756	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1248725002757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002758	S-adenosylmethionine binding site [chemical binding]; other site
1248725002759	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1248725002760	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1248725002761	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1248725002762	active site
1248725002763	HIGH motif; other site
1248725002764	KMSKS motif; other site
1248725002765	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1248725002766	anticodon binding site; other site
1248725002767	tRNA binding surface [nucleotide binding]; other site
1248725002768	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1248725002769	dimer interface [polypeptide binding]; other site
1248725002770	putative tRNA-binding site [nucleotide binding]; other site
1248725002771	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1248725002772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1248725002773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002774	S-adenosylmethionine binding site [chemical binding]; other site
1248725002775	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1248725002776	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1248725002777	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
1248725002778	GMP synthase; Reviewed; Region: guaA; PRK00074
1248725002779	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1248725002780	AMP/PPi binding site [chemical binding]; other site
1248725002781	candidate oxyanion hole; other site
1248725002782	catalytic triad [active]
1248725002783	potential glutamine specificity residues [chemical binding]; other site
1248725002784	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1248725002785	ATP Binding subdomain [chemical binding]; other site
1248725002786	Ligand Binding sites [chemical binding]; other site
1248725002787	Dimerization subdomain; other site
1248725002788	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1248725002789	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1248725002790	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1248725002791	Protein of unknown function (DUF3972); Region: DUF3972; pfam13118
1248725002792	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1248725002793	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1248725002794	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1248725002795	catalytic residue [active]
1248725002796	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1248725002797	nucleotide binding site/active site [active]
1248725002798	HIT family signature motif; other site
1248725002799	catalytic residue [active]
1248725002800	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1248725002801	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1248725002802	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1248725002803	dimer interface [polypeptide binding]; other site
1248725002804	motif 1; other site
1248725002805	active site
1248725002806	motif 2; other site
1248725002807	motif 3; other site
1248725002808	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1248725002809	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1248725002810	putative tRNA-binding site [nucleotide binding]; other site
1248725002811	tRNA synthetase B5 domain; Region: B5; pfam03484
1248725002812	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1248725002813	dimer interface [polypeptide binding]; other site
1248725002814	motif 1; other site
1248725002815	motif 3; other site
1248725002816	motif 2; other site
1248725002817	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1248725002818	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1248725002819	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1248725002820	hinge; other site
1248725002821	active site
1248725002822	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1248725002823	LytB protein; Region: LYTB; pfam02401
1248725002824	ribosomal protein S1; Region: rpsA; TIGR00717
1248725002825	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1248725002826	RNA binding site [nucleotide binding]; other site
1248725002827	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1248725002828	RNA binding site [nucleotide binding]; other site
1248725002829	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1248725002830	RNA binding site [nucleotide binding]; other site
1248725002831	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1248725002832	RNA binding site [nucleotide binding]; other site
1248725002833	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
1248725002834	RNA binding site [nucleotide binding]; other site
1248725002835	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1248725002836	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1248725002837	ligand binding site [chemical binding]; other site
1248725002838	NAD binding site [chemical binding]; other site
1248725002839	dimerization interface [polypeptide binding]; other site
1248725002840	catalytic site [active]
1248725002841	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1248725002842	putative L-serine binding site [chemical binding]; other site
1248725002843	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
1248725002844	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1248725002845	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1248725002846	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1248725002847	catalytic residue [active]
1248725002848	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1248725002849	putative active site [active]
1248725002850	putative metal binding site [ion binding]; other site
1248725002851	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1248725002852	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1248725002853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725002854	active site
1248725002855	phosphorylation site [posttranslational modification]
1248725002856	intermolecular recognition site; other site
1248725002857	dimerization interface [polypeptide binding]; other site
1248725002858	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1248725002859	putative binding surface; other site
1248725002860	active site
1248725002861	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1248725002862	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1248725002863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1248725002864	ATP binding site [chemical binding]; other site
1248725002865	Mg2+ binding site [ion binding]; other site
1248725002866	G-X-G motif; other site
1248725002867	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1248725002868	Response regulator receiver domain; Region: Response_reg; pfam00072
1248725002869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1248725002870	active site
1248725002871	phosphorylation site [posttranslational modification]
1248725002872	intermolecular recognition site; other site
1248725002873	dimerization interface [polypeptide binding]; other site
1248725002874	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1248725002875	putative CheA interaction surface; other site
1248725002876	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1248725002877	dimer interface [polypeptide binding]; other site
1248725002878	catalytic triad [active]
1248725002879	peroxidatic and resolving cysteines [active]
1248725002880	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1248725002881	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1248725002882	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1248725002883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002884	S-adenosylmethionine binding site [chemical binding]; other site
1248725002885	primosome assembly protein PriA; Validated; Region: PRK05580
1248725002886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725002887	ATP binding site [chemical binding]; other site
1248725002888	putative Mg++ binding site [ion binding]; other site
1248725002889	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1248725002890	Sporulation related domain; Region: SPOR; pfam05036
1248725002891	Peptidase family M48; Region: Peptidase_M48; pfam01435
1248725002892	HemK family putative methylases; Region: hemK_fam; TIGR00536
1248725002893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1248725002894	glutamate dehydrogenase; Provisional; Region: PRK09414
1248725002895	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1248725002896	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1248725002897	NAD(P) binding site [chemical binding]; other site
1248725002898	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
1248725002899	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1248725002900	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1248725002901	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
1248725002902	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1248725002903	catalytic residues [active]
1248725002904	ferrochelatase; Region: hemH; TIGR00109
1248725002905	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1248725002906	C-terminal domain interface [polypeptide binding]; other site
1248725002907	active site
1248725002908	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1248725002909	active site
1248725002910	N-terminal domain interface [polypeptide binding]; other site
1248725002911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1248725002912	RNA methyltransferase, RsmE family; Region: TIGR00046
1248725002913	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002914	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1248725002915	trimer interface [polypeptide binding]; other site
1248725002916	active site
1248725002917	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
1248725002918	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1248725002919	carboxyltransferase (CT) interaction site; other site
1248725002920	biotinylation site [posttranslational modification]; other site
1248725002921	biotin carboxylase; Validated; Region: PRK08462
1248725002922	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1248725002923	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1248725002924	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1248725002925	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725002926	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1248725002927	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1248725002928	inhibitor-cofactor binding pocket; inhibition site
1248725002929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725002930	catalytic residue [active]
1248725002931	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1248725002932	dimer interface [polypeptide binding]; other site
1248725002933	putative radical transfer pathway; other site
1248725002934	diiron center [ion binding]; other site
1248725002935	tyrosyl radical; other site
1248725002936	protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080
1248725002937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725002938	S-adenosylmethionine binding site [chemical binding]; other site
1248725002939	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1248725002940	Predicted permeases [General function prediction only]; Region: COG0795
1248725002941	tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071
1248725002942	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1248725002943	dimerization interface 3.5A [polypeptide binding]; other site
1248725002944	active site
1248725002945	UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179
1248725002946	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1248725002947	NAD binding site [chemical binding]; other site
1248725002948	homodimer interface [polypeptide binding]; other site
1248725002949	active site
1248725002950	substrate binding site [chemical binding]; other site
1248725002951	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1248725002952	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1248725002953	putative NAD(P) binding site [chemical binding]; other site
1248725002954	homodimer interface [polypeptide binding]; other site
1248725002955	homotetramer interface [polypeptide binding]; other site
1248725002956	active site
1248725002957	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725002958	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725002959	binding surface
1248725002960	TPR motif; other site
1248725002961	Sel1-like repeats; Region: SEL1; smart00671
1248725002962	Sel1-like repeats; Region: SEL1; smart00671
1248725002963	Sel1-like repeats; Region: SEL1; smart00671
1248725002964	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1248725002965	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1248725002966	active site
1248725002967	intersubunit interface [polypeptide binding]; other site
1248725002968	catalytic residue [active]
1248725002969	phosphogluconate dehydratase; Validated; Region: PRK09054
1248725002970	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1248725002971	Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364
1248725002972	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1248725002973	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1248725002974	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1248725002975	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1248725002976	putative active site [active]
1248725002977	glucokinase, proteobacterial type; Region: glk; TIGR00749
1248725002978	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1248725002979	nucleotide binding site [chemical binding]; other site
1248725002980	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1248725002981	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1248725002982	putative NAD(P) binding site [chemical binding]; other site
1248725002983	putative substrate binding site [chemical binding]; other site
1248725002984	catalytic Zn binding site [ion binding]; other site
1248725002985	structural Zn binding site [ion binding]; other site
1248725002986	dimer interface [polypeptide binding]; other site
1248725002987	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725002988	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725002989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1248725002990	active site
1248725002991	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725002992	pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844
1248725002993	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
1248725002994	pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625
1248725002995	4Fe-4S binding domain; Region: Fer4; pfam00037
1248725002996	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
1248725002997	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1248725002998	dimer interface [polypeptide binding]; other site
1248725002999	PYR/PP interface [polypeptide binding]; other site
1248725003000	TPP binding site [chemical binding]; other site
1248725003001	substrate binding site [chemical binding]; other site
1248725003002	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1248725003003	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
1248725003004	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
1248725003005	TPP-binding site [chemical binding]; other site
1248725003006	putative dimer interface [polypeptide binding]; other site
1248725003007	adenylosuccinate lyase; Provisional; Region: PRK08470
1248725003008	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1248725003009	tetramer interface [polypeptide binding]; other site
1248725003010	active site
1248725003011	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1248725003012	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003013	excinuclease ABC subunit B; Provisional; Region: PRK05298
1248725003014	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725003015	ATP binding site [chemical binding]; other site
1248725003016	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1248725003017	putative Mg++ binding site [ion binding]; other site
1248725003018	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725003019	nucleotide binding region [chemical binding]; other site
1248725003020	ATP-binding site [chemical binding]; other site
1248725003021	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1248725003022	UvrB/uvrC motif; Region: UVR; pfam02151
1248725003023	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1248725003024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725003025	binding surface
1248725003026	TPR motif; other site
1248725003027	Sel1-like repeats; Region: SEL1; smart00671
1248725003028	Sel1-like repeats; Region: SEL1; smart00671
1248725003029	Sel1-like repeats; Region: SEL1; smart00671
1248725003030	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1248725003031	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1248725003032	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
1248725003033	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1248725003034	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1248725003035	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
1248725003036	cofactor binding site; other site
1248725003037	DNA binding site [nucleotide binding]
1248725003038	substrate interaction site [chemical binding]; other site
1248725003039	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
1248725003040	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1248725003041	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1248725003042	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1248725003043	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1248725003044	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1248725003045	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1248725003046	ligand binding site [chemical binding]; other site
1248725003047	translocation protein TolB; Provisional; Region: tolB; PRK04043
1248725003048	TolB amino-terminal domain; Region: TolB_N; pfam04052
1248725003049	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1248725003050	TonB C terminal; Region: TonB_2; pfam13103
1248725003051	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1248725003052	TolR protein; Region: tolR; TIGR02801
1248725003053	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1248725003054	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
1248725003055	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1248725003056	gamma subunit interface [polypeptide binding]; other site
1248725003057	epsilon subunit interface [polypeptide binding]; other site
1248725003058	LBP interface [polypeptide binding]; other site
1248725003059	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1248725003060	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1248725003061	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1248725003062	alpha subunit interaction interface [polypeptide binding]; other site
1248725003063	Walker A motif; other site
1248725003064	ATP binding site [chemical binding]; other site
1248725003065	Walker B motif; other site
1248725003066	inhibitor binding site; inhibition site
1248725003067	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1248725003068	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1248725003069	core domain interface [polypeptide binding]; other site
1248725003070	delta subunit interface [polypeptide binding]; other site
1248725003071	epsilon subunit interface [polypeptide binding]; other site
1248725003072	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1248725003073	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1248725003074	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1248725003075	beta subunit interaction interface [polypeptide binding]; other site
1248725003076	Walker A motif; other site
1248725003077	ATP binding site [chemical binding]; other site
1248725003078	Walker B motif; other site
1248725003079	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1248725003080	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13431
1248725003081	F0F1 ATP synthase subunit B; Validated; Region: PRK08475
1248725003082	F0F1 ATP synthase subunit B'; Validated; Region: PRK08476
1248725003083	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1248725003084	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1248725003085	ParB-like nuclease domain; Region: ParB; smart00470
1248725003086	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1248725003087	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1248725003088	P-loop; other site
1248725003089	Magnesium ion binding site [ion binding]; other site
1248725003090	biotin--protein ligase; Provisional; Region: PRK08477
1248725003091	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1248725003092	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1248725003093	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1248725003094	putative active site [active]
1248725003095	substrate binding site [chemical binding]; other site
1248725003096	putative cosubstrate binding site; other site
1248725003097	catalytic site [active]
1248725003098	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
1248725003099	PHP-associated; Region: PHP_C; pfam13263
1248725003100	AAA domain; Region: AAA_23; pfam13476
1248725003101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725003102	Walker A/P-loop; other site
1248725003103	ATP binding site [chemical binding]; other site
1248725003104	AAA domain; Region: AAA_21; pfam13304
1248725003105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
1248725003106	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
1248725003107	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1248725003108	tRNA (guanine-N1)-methyltransferase; Region: trmD; TIGR00088
1248725003109	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593
1248725003110	RimM N-terminal domain; Region: RimM; pfam01782
1248725003111	PRC-barrel domain; Region: PRC; pfam05239
1248725003112	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1248725003113	KH domain; Region: KH_4; pfam13083
1248725003114	G-X-X-G motif; other site
1248725003115	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1248725003116	signal recognition particle protein; Provisional; Region: PRK10867
1248725003117	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1248725003118	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1248725003119	P loop; other site
1248725003120	GTP binding site [chemical binding]; other site
1248725003121	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1248725003122	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1248725003123	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1248725003124	active site
1248725003125	HIGH motif; other site
1248725003126	nucleotide binding site [chemical binding]; other site
1248725003127	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1248725003128	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1248725003129	active site
1248725003130	KMSKS motif; other site
1248725003131	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1248725003132	anticodon binding site; other site
1248725003133	flagellar assembly protein FliW; Provisional; Region: PRK13283
1248725003134	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1248725003135	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1248725003136	active site
1248725003137	homodimer interface [polypeptide binding]; other site
1248725003138	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003139	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003140	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1248725003141	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1248725003142	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1248725003143	Fic/DOC family; Region: Fic; cl00960
1248725003144	metal-binding heat shock protein; Provisional; Region: PRK00016
1248725003145	flavodoxin FldA; Validated; Region: PRK09267
1248725003146	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1248725003147	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1248725003148	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
1248725003149	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1248725003150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1248725003151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1248725003152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725003153	putative substrate translocation pore; other site
1248725003154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1248725003155	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1248725003156	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1248725003157	active site
1248725003158	dimer interface [polypeptide binding]; other site
1248725003159	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1248725003160	dimer interface [polypeptide binding]; other site
1248725003161	active site
1248725003162	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
1248725003163	carbon starvation protein A; Provisional; Region: PRK15015
1248725003164	Carbon starvation protein CstA; Region: CstA; pfam02554
1248725003165	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1248725003166	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1248725003167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725003168	dimer interface [polypeptide binding]; other site
1248725003169	conserved gate region; other site
1248725003170	putative PBP binding loops; other site
1248725003171	ABC-ATPase subunit interface; other site
1248725003172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725003173	dimer interface [polypeptide binding]; other site
1248725003174	conserved gate region; other site
1248725003175	putative PBP binding loops; other site
1248725003176	ABC-ATPase subunit interface; other site
1248725003177	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1248725003178	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1248725003179	Walker A/P-loop; other site
1248725003180	ATP binding site [chemical binding]; other site
1248725003181	Q-loop/lid; other site
1248725003182	ABC transporter signature motif; other site
1248725003183	Walker B; other site
1248725003184	D-loop; other site
1248725003185	H-loop/switch region; other site
1248725003186	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1248725003187	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1248725003188	substrate binding pocket [chemical binding]; other site
1248725003189	membrane-bound complex binding site; other site
1248725003190	hinge residues; other site
1248725003191	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1248725003192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725003193	putative substrate translocation pore; other site
1248725003194	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1248725003195	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003196	purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107
1248725003197	phosphopentomutase; Provisional; Region: PRK05362
1248725003198	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1248725003199	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1248725003200	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1248725003201	Nucleoside recognition; Region: Gate; pfam07670
1248725003202	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1248725003203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725003204	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1248725003205	putative substrate translocation pore; other site
1248725003206	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1248725003207	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1248725003208	Ligand Binding Site [chemical binding]; other site
1248725003209	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1248725003210	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1248725003211	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1248725003212	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1248725003213	putative arabinose transporter; Provisional; Region: PRK03545
1248725003214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1248725003215	putative substrate translocation pore; other site
1248725003216	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
1248725003217	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1248725003218	active site
1248725003219	zinc binding site [ion binding]; other site
1248725003220	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
1248725003221	aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296
1248725003222	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1248725003223	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
1248725003224	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1248725003225	dimer interface [polypeptide binding]; other site
1248725003226	motif 1; other site
1248725003227	active site
1248725003228	motif 2; other site
1248725003229	motif 3; other site
1248725003230	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1248725003231	anticodon binding site; other site
1248725003232	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1248725003233	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1248725003234	putative active site [active]
1248725003235	elongation factor G; Reviewed; Region: PRK00007
1248725003236	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1248725003237	G1 box; other site
1248725003238	putative GEF interaction site [polypeptide binding]; other site
1248725003239	GTP/Mg2+ binding site [chemical binding]; other site
1248725003240	Switch I region; other site
1248725003241	G2 box; other site
1248725003242	G3 box; other site
1248725003243	Switch II region; other site
1248725003244	G4 box; other site
1248725003245	G5 box; other site
1248725003246	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1248725003247	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1248725003248	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1248725003249	30S ribosomal protein S7; Validated; Region: PRK05302
1248725003250	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1248725003251	S17 interaction site [polypeptide binding]; other site
1248725003252	S8 interaction site; other site
1248725003253	16S rRNA interaction site [nucleotide binding]; other site
1248725003254	streptomycin interaction site [chemical binding]; other site
1248725003255	23S rRNA interaction site [nucleotide binding]; other site
1248725003256	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1248725003257	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
1248725003258	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1248725003259	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1248725003260	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1248725003261	RPB11 interaction site [polypeptide binding]; other site
1248725003262	RPB12 interaction site [polypeptide binding]; other site
1248725003263	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1248725003264	RPB3 interaction site [polypeptide binding]; other site
1248725003265	RPB1 interaction site [polypeptide binding]; other site
1248725003266	RPB11 interaction site [polypeptide binding]; other site
1248725003267	RPB10 interaction site [polypeptide binding]; other site
1248725003268	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1248725003269	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1248725003270	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1248725003271	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1248725003272	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1248725003273	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1248725003274	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1248725003275	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1248725003276	DNA binding site [nucleotide binding]
1248725003277	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1248725003278	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1248725003279	core dimer interface [polypeptide binding]; other site
1248725003280	peripheral dimer interface [polypeptide binding]; other site
1248725003281	L10 interface [polypeptide binding]; other site
1248725003282	L11 interface [polypeptide binding]; other site
1248725003283	putative EF-Tu interaction site [polypeptide binding]; other site
1248725003284	putative EF-G interaction site [polypeptide binding]; other site
1248725003285	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1248725003286	23S rRNA interface [nucleotide binding]; other site
1248725003287	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1248725003288	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1248725003289	mRNA/rRNA interface [nucleotide binding]; other site
1248725003290	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1248725003291	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1248725003292	23S rRNA interface [nucleotide binding]; other site
1248725003293	L7/L12 interface [polypeptide binding]; other site
1248725003294	putative thiostrepton binding site; other site
1248725003295	L25 interface [polypeptide binding]; other site
1248725003296	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1248725003297	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1248725003298	putative homodimer interface [polypeptide binding]; other site
1248725003299	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1248725003300	heterodimer interface [polypeptide binding]; other site
1248725003301	homodimer interface [polypeptide binding]; other site
1248725003302	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
1248725003303	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1248725003304	elongation factor Tu; Reviewed; Region: PRK00049
1248725003305	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1248725003306	G1 box; other site
1248725003307	GEF interaction site [polypeptide binding]; other site
1248725003308	GTP/Mg2+ binding site [chemical binding]; other site
1248725003309	Switch I region; other site
1248725003310	G2 box; other site
1248725003311	G3 box; other site
1248725003312	Switch II region; other site
1248725003313	G4 box; other site
1248725003314	G5 box; other site
1248725003315	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1248725003316	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1248725003317	Antibiotic Binding Site [chemical binding]; other site
1248725003318	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1248725003319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725003320	Walker A/P-loop; other site
1248725003321	ATP binding site [chemical binding]; other site
1248725003322	Q-loop/lid; other site
1248725003323	ABC transporter signature motif; other site
1248725003324	Walker B; other site
1248725003325	D-loop; other site
1248725003326	H-loop/switch region; other site
1248725003327	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1248725003328	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1248725003329	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
1248725003330	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086
1248725003331	ICEA Protein; Region: ICEA; pfam05315
1248725003332	ICEA Protein; Region: ICEA; pfam05315
1248725003333	serine O-acetyltransferase; Region: cysE; TIGR01172
1248725003334	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1248725003335	trimer interface [polypeptide binding]; other site
1248725003336	active site
1248725003337	substrate binding site [chemical binding]; other site
1248725003338	CoA binding site [chemical binding]; other site
1248725003339	F0F1 ATP synthase subunit C; Validated; Region: PRK08482
1248725003340	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1248725003341	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1248725003342	oligomer interface [polypeptide binding]; other site
1248725003343	RNA binding site [nucleotide binding]; other site
1248725003344	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1248725003345	oligomer interface [polypeptide binding]; other site
1248725003346	RNA binding site [nucleotide binding]; other site
1248725003347	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1248725003348	putative nucleic acid binding region [nucleotide binding]; other site
1248725003349	G-X-X-G motif; other site
1248725003350	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1248725003351	RNA binding site [nucleotide binding]; other site
1248725003352	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
1248725003353	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1248725003354	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1248725003355	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1248725003356	phosphoribosylamine--glycine ligase; Region: purD; TIGR00877
1248725003357	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1248725003358	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1248725003359	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1248725003360	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1248725003361	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1248725003362	Walker A/P-loop; other site
1248725003363	ATP binding site [chemical binding]; other site
1248725003364	Q-loop/lid; other site
1248725003365	ABC transporter signature motif; other site
1248725003366	Walker B; other site
1248725003367	D-loop; other site
1248725003368	H-loop/switch region; other site
1248725003369	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1248725003370	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1248725003371	catalytic residue [active]
1248725003372	putative FPP diphosphate  binding site; other site
1248725003373	putative FPP binding hydrophobic cleft; other site
1248725003374	dimer interface [polypeptide binding]; other site
1248725003375	putative IPP diphosphate binding site; other site
1248725003376	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1248725003377	FAD binding domain; Region: FAD_binding_4; pfam01565
1248725003378	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1248725003379	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1248725003380	active site residue [active]
1248725003381	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1248725003382	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1248725003383	active site
1248725003384	camphor resistance protein CrcB; Provisional; Region: PRK14204
1248725003385	coproporphyrinogen III oxidase; Provisional; Region: PRK08446
1248725003386	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725003387	FeS/SAM binding site; other site
1248725003388	HemN C-terminal domain; Region: HemN_C; pfam06969
1248725003389	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1248725003390	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1248725003391	putative active site [active]
1248725003392	Ap4A binding site [chemical binding]; other site
1248725003393	nudix motif; other site
1248725003394	putative metal binding site [ion binding]; other site
1248725003395	aspartate kinase; Reviewed; Region: PRK06635
1248725003396	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1248725003397	putative nucleotide binding site [chemical binding]; other site
1248725003398	putative catalytic residues [active]
1248725003399	putative Mg ion binding site [ion binding]; other site
1248725003400	putative aspartate binding site [chemical binding]; other site
1248725003401	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1248725003402	putative allosteric regulatory site; other site
1248725003403	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1248725003404	putative allosteric regulatory residue; other site
1248725003405	DNA replication regulator; Region: HobA; pfam12163
1248725003406	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1248725003407	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1248725003408	dihydropteroate synthase; Region: DHPS; TIGR01496
1248725003409	substrate binding pocket [chemical binding]; other site
1248725003410	dimer interface [polypeptide binding]; other site
1248725003411	inhibitor binding site; inhibition site
1248725003412	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1248725003413	EamA-like transporter family; Region: EamA; pfam00892
1248725003414	EamA-like transporter family; Region: EamA; cl17759
1248725003415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952
1248725003416	Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505
1248725003417	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1248725003418	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1248725003419	catalytic site [active]
1248725003420	subunit interface [polypeptide binding]; other site
1248725003421	formamidase; Provisional; Region: amiF; PRK13287
1248725003422	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
1248725003423	multimer interface [polypeptide binding]; other site
1248725003424	active site
1248725003425	catalytic triad [active]
1248725003426	dimer interface [polypeptide binding]; other site
1248725003427	Maf-like protein; Region: Maf; pfam02545
1248725003428	Maf-like protein; Reviewed; Region: PRK04056
1248725003429	putative active site [active]
1248725003430	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1248725003431	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1248725003432	motif 1; other site
1248725003433	active site
1248725003434	motif 2; other site
1248725003435	motif 3; other site
1248725003436	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1248725003437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
1248725003438	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003439	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1248725003440	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1248725003441	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1248725003442	dimer interface [polypeptide binding]; other site
1248725003443	ssDNA binding site [nucleotide binding]; other site
1248725003444	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1248725003445	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1248725003446	DNA polymerase III subunit delta; Validated; Region: PRK08487
1248725003447	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1248725003448	RNB domain; Region: RNB; pfam00773
1248725003449	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1248725003450	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
1248725003451	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1248725003452	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1248725003453	shikimate binding site; other site
1248725003454	NAD(P) binding site [chemical binding]; other site
1248725003455	Bacterial SH3 domain; Region: SH3_3; pfam08239
1248725003456	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1248725003457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1248725003458	dimer interface [polypeptide binding]; other site
1248725003459	conserved gate region; other site
1248725003460	putative PBP binding loops; other site
1248725003461	ABC-ATPase subunit interface; other site
1248725003462	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1248725003463	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1248725003464	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1248725003465	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1248725003466	active site
1248725003467	HIGH motif; other site
1248725003468	dimer interface [polypeptide binding]; other site
1248725003469	KMSKS motif; other site
1248725003470	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1248725003471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725003472	S-adenosylmethionine binding site [chemical binding]; other site
1248725003473	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1248725003474	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1248725003475	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1248725003476	hinge region; other site
1248725003477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1248725003478	active site
1248725003479	RDD family; Region: RDD; pfam06271
1248725003480	NAD-dependent deacetylase; Provisional; Region: PRK00481
1248725003481	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1248725003482	NAD+ binding site [chemical binding]; other site
1248725003483	substrate binding site [chemical binding]; other site
1248725003484	Zn binding site [ion binding]; other site
1248725003485	NADH dehydrogenase subunit A; Validated; Region: PRK08489
1248725003486	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1248725003487	NADH dehydrogenase subunit C; Provisional; Region: PRK08491
1248725003488	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1248725003489	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1248725003490	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1248725003491	NADH dehydrogenase subunit G; Validated; Region: PRK08493
1248725003492	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1248725003493	catalytic loop [active]
1248725003494	iron binding site [ion binding]; other site
1248725003495	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1248725003496	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1248725003497	molybdopterin cofactor binding site; other site
1248725003498	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1248725003499	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1248725003500	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1248725003501	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1248725003502	4Fe-4S binding domain; Region: Fer4; cl02805
1248725003503	4Fe-4S binding domain; Region: Fer4; pfam00037
1248725003504	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1248725003505	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1248725003506	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1248725003507	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1248725003508	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1248725003509	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1248725003510	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1248725003511	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1248725003512	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
1248725003513	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1248725003514	Outer membrane lipoprotein; Region: YfiO; pfam13525
1248725003515	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1248725003516	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1248725003517	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1248725003518	active site
1248725003519	substrate binding site [chemical binding]; other site
1248725003520	metal binding site [ion binding]; metal-binding site
1248725003521	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1248725003522	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1248725003523	substrate binding site [chemical binding]; other site
1248725003524	active site
1248725003525	catalytic residues [active]
1248725003526	heterodimer interface [polypeptide binding]; other site
1248725003527	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1248725003528	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1248725003529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1248725003530	catalytic residue [active]
1248725003531	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1248725003532	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1248725003533	active site
1248725003534	ribulose/triose binding site [chemical binding]; other site
1248725003535	phosphate binding site [ion binding]; other site
1248725003536	substrate (anthranilate) binding pocket [chemical binding]; other site
1248725003537	product (indole) binding pocket [chemical binding]; other site
1248725003538	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1248725003539	active site
1248725003540	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1248725003541	anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245
1248725003542	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1248725003543	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1248725003544	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1248725003545	glutamine binding [chemical binding]; other site
1248725003546	catalytic triad [active]
1248725003547	anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565
1248725003548	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1248725003549	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1248725003550	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1248725003551	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1248725003552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1248725003553	active site
1248725003554	motif I; other site
1248725003555	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1248725003556	motif II; other site
1248725003557	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1248725003558	thiaminase II; Region: salvage_TenA; TIGR04306
1248725003559	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1248725003560	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1248725003561	Thiamine pyrophosphokinase; Region: TPK; cd07995
1248725003562	active site
1248725003563	dimerization interface [polypeptide binding]; other site
1248725003564	thiamine binding site [chemical binding]; other site
1248725003565	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
1248725003566	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1248725003567	alphaNTD homodimer interface [polypeptide binding]; other site
1248725003568	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
1248725003569	alphaNTD - beta interaction site [polypeptide binding]; other site
1248725003570	alphaNTD - beta' interaction site [polypeptide binding]; other site
1248725003571	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1248725003572	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1248725003573	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1248725003574	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1248725003575	RNA binding surface [nucleotide binding]; other site
1248725003576	30S ribosomal protein S11; Validated; Region: PRK05309
1248725003577	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1248725003578	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1248725003579	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1248725003580	rRNA binding site [nucleotide binding]; other site
1248725003581	predicted 30S ribosome binding site; other site
1248725003582	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1248725003583	active site
1248725003584	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1248725003585	SecY translocase; Region: SecY; pfam00344
1248725003586	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1248725003587	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1248725003588	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1248725003589	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1248725003590	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1248725003591	23S rRNA interface [nucleotide binding]; other site
1248725003592	5S rRNA interface [nucleotide binding]; other site
1248725003593	L27 interface [polypeptide binding]; other site
1248725003594	L5 interface [polypeptide binding]; other site
1248725003595	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1248725003596	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1248725003597	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1248725003598	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1248725003599	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1248725003600	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1248725003601	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1248725003602	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1248725003603	RNA binding site [nucleotide binding]; other site
1248725003604	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1248725003605	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1248725003606	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1248725003607	putative translocon interaction site; other site
1248725003608	23S rRNA interface [nucleotide binding]; other site
1248725003609	signal recognition particle (SRP54) interaction site; other site
1248725003610	L23 interface [polypeptide binding]; other site
1248725003611	trigger factor interaction site; other site
1248725003612	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1248725003613	23S rRNA interface [nucleotide binding]; other site
1248725003614	5S rRNA interface [nucleotide binding]; other site
1248725003615	putative antibiotic binding site [chemical binding]; other site
1248725003616	L25 interface [polypeptide binding]; other site
1248725003617	L27 interface [polypeptide binding]; other site
1248725003618	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1248725003619	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1248725003620	G-X-X-G motif; other site
1248725003621	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1248725003622	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1248725003623	putative translocon binding site; other site
1248725003624	protein-rRNA interface [nucleotide binding]; other site
1248725003625	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1248725003626	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1248725003627	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1248725003628	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1248725003629	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1248725003630	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1248725003631	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1248725003632	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1248725003633	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1248725003634	AAA domain; Region: AAA_14; pfam13173
1248725003635	Helix-turn-helix domain; Region: HTH_36; pfam13730
1248725003636	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1248725003637	RNA/DNA hybrid binding site [nucleotide binding]; other site
1248725003638	active site
1248725003639	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1248725003640	Class II fumarases; Region: Fumarase_classII; cd01362
1248725003641	active site
1248725003642	tetramer interface [polypeptide binding]; other site
1248725003643	YtkA-like; Region: YtkA; pfam13115
1248725003644	Outer membrane efflux protein; Region: OEP; pfam02321
1248725003645	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1248725003646	HlyD family secretion protein; Region: HlyD_3; pfam13437
1248725003647	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1248725003648	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
1248725003649	AzlC protein; Region: AzlC; cl00570
1248725003650	chaperone protein DnaJ; Provisional; Region: PRK14288
1248725003651	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1248725003652	HSP70 interaction site [polypeptide binding]; other site
1248725003653	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1248725003654	substrate binding site [polypeptide binding]; other site
1248725003655	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1248725003656	Zn binding sites [ion binding]; other site
1248725003657	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1248725003658	dimer interface [polypeptide binding]; other site
1248725003659	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1248725003660	LabA_like proteins; Region: LabA_like; cd06167
1248725003661	putative metal binding site [ion binding]; other site
1248725003662	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1248725003663	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1248725003664	Ligand Binding Site [chemical binding]; other site
1248725003665	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1248725003666	HSP70 interaction site [polypeptide binding]; other site
1248725003667	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1248725003668	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1248725003669	active site
1248725003670	(T/H)XGH motif; other site
1248725003671	nickel responsive regulator; Provisional; Region: PRK00630
1248725003672	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1248725003673	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1248725003674	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
1248725003675	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1248725003676	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1248725003677	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1248725003678	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1248725003679	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1248725003680	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725003681	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957
1248725003682	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1248725003683	Acylphosphatase; Region: Acylphosphatase; pfam00708
1248725003684	[NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143
1248725003685	HypF finger; Region: zf-HYPF; pfam07503
1248725003686	HypF finger; Region: zf-HYPF; pfam07503
1248725003687	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1248725003688	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1248725003689	dimerization interface [polypeptide binding]; other site
1248725003690	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1248725003691	ATP binding site [chemical binding]; other site
1248725003692	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1248725003693	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1248725003694	NADP binding site [chemical binding]; other site
1248725003695	active site
1248725003696	putative substrate binding site [chemical binding]; other site
1248725003697	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
1248725003698	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1248725003699	NADP-binding site; other site
1248725003700	homotetramer interface [polypeptide binding]; other site
1248725003701	substrate binding site [chemical binding]; other site
1248725003702	homodimer interface [polypeptide binding]; other site
1248725003703	active site
1248725003704	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1248725003705	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1248725003706	Substrate binding site; other site
1248725003707	Cupin domain; Region: Cupin_2; cl17218
1248725003708	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1248725003709	Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504
1248725003710	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1248725003711	VirB7 interaction site; other site
1248725003712	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
1248725003713	Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846
1248725003714	PDZ domain; Region: PDZ_2; pfam13180
1248725003715	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1248725003716	hypothetical protein; Provisional; Region: PRK03762
1248725003717	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1248725003718	tetramerization interface [polypeptide binding]; other site
1248725003719	active site
1248725003720	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1248725003721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725003722	Walker A motif; other site
1248725003723	ATP binding site [chemical binding]; other site
1248725003724	Walker B motif; other site
1248725003725	arginine finger; other site
1248725003726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725003727	Walker A motif; other site
1248725003728	ATP binding site [chemical binding]; other site
1248725003729	Walker B motif; other site
1248725003730	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1248725003731	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1248725003732	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1248725003733	Ligand Binding Site [chemical binding]; other site
1248725003734	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1248725003735	AAA domain; Region: AAA_26; pfam13500
1248725003736	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
1248725003737	isocitrate dehydrogenase; Validated; Region: PRK07362
1248725003738	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1248725003739	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1248725003740	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1248725003741	dimer interface [polypeptide binding]; other site
1248725003742	active site
1248725003743	citrylCoA binding site [chemical binding]; other site
1248725003744	NADH binding [chemical binding]; other site
1248725003745	cationic pore residues; other site
1248725003746	oxalacetate/citrate binding site [chemical binding]; other site
1248725003747	coenzyme A binding site [chemical binding]; other site
1248725003748	catalytic triad [active]
1248725003749	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
1248725003750	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1248725003751	active site
1248725003752	substrate binding site [chemical binding]; other site
1248725003753	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
1248725003754	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1248725003755	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1248725003756	Walker A/P-loop; other site
1248725003757	ATP binding site [chemical binding]; other site
1248725003758	Q-loop/lid; other site
1248725003759	ABC transporter signature motif; other site
1248725003760	Walker B; other site
1248725003761	D-loop; other site
1248725003762	H-loop/switch region; other site
1248725003763	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
1248725003764	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1248725003765	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725003766	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725003767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
1248725003768	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1248725003769	ATP binding site [chemical binding]; other site
1248725003770	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1248725003771	putative Mg++ binding site [ion binding]; other site
1248725003772	biotin synthase; Provisional; Region: PRK08508
1248725003773	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725003774	FeS/SAM binding site; other site
1248725003775	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1248725003776	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
1248725003777	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725003778	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725003779	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725003780	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725003781	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725003782	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725003783	7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139
1248725003784	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1248725003785	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1248725003786	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
1248725003787	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1248725003788	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1248725003789	Ligand binding site; other site
1248725003790	metal-binding site
1248725003791	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1248725003792	Sulfatase; Region: Sulfatase; pfam00884
1248725003793	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904
1248725003794	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1248725003795	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1248725003796	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472
1248725003797	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1248725003798	Walker A motif/ATP binding site; other site
1248725003799	Walker B motif; other site
1248725003800	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
1248725003801	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1248725003802	ATP binding site [chemical binding]; other site
1248725003803	Walker A motif; other site
1248725003804	hexamer interface [polypeptide binding]; other site
1248725003805	Walker B motif; other site
1248725003806	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1248725003807	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1248725003808	active site
1248725003809	HIGH motif; other site
1248725003810	nucleotide binding site [chemical binding]; other site
1248725003811	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1248725003812	active site
1248725003813	KMSKS motif; other site
1248725003814	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1248725003815	tRNA binding surface [nucleotide binding]; other site
1248725003816	anticodon binding site; other site
1248725003817	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1248725003818	RNA binding surface [nucleotide binding]; other site
1248725003819	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
1248725003820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1248725003821	FeS/SAM binding site; other site
1248725003822	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1248725003823	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1248725003824	putative active site [active]
1248725003825	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1248725003826	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1248725003827	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1248725003828	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1248725003829	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1248725003830	dimethyladenosine transferase; Region: ksgA; TIGR00755
1248725003831	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
1248725003832	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1248725003833	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1248725003834	active site
1248725003835	substrate binding site [chemical binding]; other site
1248725003836	cosubstrate binding site; other site
1248725003837	catalytic site [active]
1248725003838	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1248725003839	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1248725003840	tandem repeat interface [polypeptide binding]; other site
1248725003841	oligomer interface [polypeptide binding]; other site
1248725003842	active site residues [active]
1248725003843	enterobactin exporter EntS; Provisional; Region: PRK10489
1248725003844	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1248725003845	active site
1248725003846	carbon storage regulator; Provisional; Region: PRK00568
1248725003847	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
1248725003848	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1248725003849	SmpB-tmRNA interface; other site
1248725003850	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1248725003851	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1248725003852	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1248725003853	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1248725003854	ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188
1248725003855	hypothetical protein; Provisional; Region: PRK14374
1248725003856	membrane protein insertase; Provisional; Region: PRK01318
1248725003857	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1248725003858	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1248725003859	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1248725003860	tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450
1248725003861	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1248725003862	GTP/Mg2+ binding site [chemical binding]; other site
1248725003863	G4 box; other site
1248725003864	G5 box; other site
1248725003865	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1248725003866	G1 box; other site
1248725003867	G1 box; other site
1248725003868	GTP/Mg2+ binding site [chemical binding]; other site
1248725003869	Switch I region; other site
1248725003870	Switch I region; other site
1248725003871	G2 box; other site
1248725003872	G2 box; other site
1248725003873	Switch II region; other site
1248725003874	G3 box; other site
1248725003875	G3 box; other site
1248725003876	Switch II region; other site
1248725003877	G4 box; other site
1248725003878	G5 box; other site
1248725003879	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1248725003880	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003881	LPP20 lipoprotein; Region: LPP20; pfam02169
1248725003882	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
1248725003883	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1248725003884	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1248725003885	catalytic residues [active]
1248725003886	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1248725003887	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1248725003888	RNA binding surface [nucleotide binding]; other site
1248725003889	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1248725003890	active site
1248725003891	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1248725003892	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1248725003893	active site
1248725003894	PHP Thumb interface [polypeptide binding]; other site
1248725003895	metal binding site [ion binding]; metal-binding site
1248725003896	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1248725003897	generic binding surface I; other site
1248725003898	generic binding surface II; other site
1248725003899	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1248725003900	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
1248725003901	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1248725003902	mce related protein; Region: MCE; pfam02470
1248725003903	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1248725003904	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1248725003905	Walker A/P-loop; other site
1248725003906	ATP binding site [chemical binding]; other site
1248725003907	Q-loop/lid; other site
1248725003908	ABC transporter signature motif; other site
1248725003909	Walker B; other site
1248725003910	D-loop; other site
1248725003911	H-loop/switch region; other site
1248725003912	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1248725003913	conserved hypothetical integral membrane protein; Region: TIGR00056
1248725003914	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003915	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1248725003916	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1248725003917	homodimer interface [polypeptide binding]; other site
1248725003918	substrate-cofactor binding pocket; other site
1248725003919	catalytic residue [active]
1248725003920	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725003921	DNA polymerase I; Region: pola; TIGR00593
1248725003922	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1248725003923	active site
1248725003924	metal binding site 1 [ion binding]; metal-binding site
1248725003925	putative 5' ssDNA interaction site; other site
1248725003926	metal binding site 3; metal-binding site
1248725003927	metal binding site 2 [ion binding]; metal-binding site
1248725003928	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1248725003929	putative DNA binding site [nucleotide binding]; other site
1248725003930	putative metal binding site [ion binding]; other site
1248725003931	3'-5' exonuclease; Region: 35EXOc; smart00474
1248725003932	active site
1248725003933	substrate binding site [chemical binding]; other site
1248725003934	catalytic site [active]
1248725003935	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1248725003936	active site
1248725003937	DNA binding site [nucleotide binding]
1248725003938	catalytic site [active]
1248725003939	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725003940	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725003941	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1248725003942	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1248725003943	thymidylate kinase; Validated; Region: tmk; PRK00698
1248725003944	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1248725003945	TMP-binding site; other site
1248725003946	ATP-binding site [chemical binding]; other site
1248725003947	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1248725003948	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1248725003949	active site
1248725003950	(T/H)XGH motif; other site
1248725003951	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1248725003952	Flavoprotein; Region: Flavoprotein; pfam02441
1248725003953	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515
1248725003954	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
1248725003955	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1248725003956	Part of AAA domain; Region: AAA_19; pfam13245
1248725003957	Family description; Region: UvrD_C_2; pfam13538
1248725003958	TPR repeat; Region: TPR_11; pfam13414
1248725003959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725003960	TPR motif; other site
1248725003961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1248725003962	binding surface
1248725003963	TPR motif; other site
1248725003964	seryl-tRNA synthetase; Provisional; Region: PRK05431
1248725003965	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1248725003966	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1248725003967	dimer interface [polypeptide binding]; other site
1248725003968	active site
1248725003969	motif 1; other site
1248725003970	motif 2; other site
1248725003971	motif 3; other site
1248725003972	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1248725003973	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1248725003974	active site
1248725003975	catalytic triad [active]
1248725003976	dimer interface [polypeptide binding]; other site
1248725003977	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14065
1248725003978	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1248725003979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725003980	S-adenosylmethionine binding site [chemical binding]; other site
1248725003981	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1248725003982	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
1248725003983	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1248725003984	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1248725003985	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1248725003986	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1248725003987	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1248725003988	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1248725003989	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1248725003990	HlyD family secretion protein; Region: HlyD_3; pfam13437
1248725003991	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1248725003992	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1248725003993	Domain of unknown function DUF21; Region: DUF21; pfam01595
1248725003994	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1248725003995	Transporter associated domain; Region: CorC_HlyC; smart01091
1248725003996	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1248725003997	Phosphate transporter family; Region: PHO4; pfam01384
1248725003998	NifU-like domain; Region: NifU; pfam01106
1248725003999	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
1248725004000	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1248725004001	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1248725004002	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1248725004003	putative active site [active]
1248725004004	transaldolase; Provisional; Region: PRK03903
1248725004005	catalytic residue [active]
1248725004006	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1248725004007	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1248725004008	5S rRNA interface [nucleotide binding]; other site
1248725004009	CTC domain interface [polypeptide binding]; other site
1248725004010	L16 interface [polypeptide binding]; other site
1248725004011	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1248725004012	putative active site [active]
1248725004013	catalytic residue [active]
1248725004014	Predicted permeases [General function prediction only]; Region: COG0795
1248725004015	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1248725004016	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
1248725004017	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1248725004018	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1248725004019	AlwI restriction endonuclease; Region: RE_AlwI; pfam09491
1248725004020	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725004021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
1248725004022	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1248725004023	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1248725004024	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1248725004025	metal-binding site [ion binding]
1248725004026	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1248725004027	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1248725004028	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1248725004029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1248725004030	S-adenosylmethionine binding site [chemical binding]; other site
1248725004031	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1248725004032	catalytic motif [active]
1248725004033	Zn binding site [ion binding]; other site
1248725004034	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1248725004035	RibD C-terminal domain; Region: RibD_C; cl17279
1248725004036	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1248725004037	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1248725004038	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1248725004039	NAD(P) binding pocket [chemical binding]; other site
1248725004040	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1248725004041	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1248725004042	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1248725004043	acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023
1248725004044	FolB domain; Region: folB_dom; TIGR00526
1248725004045	active site
1248725004046	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1248725004047	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725004048	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1248725004049	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1248725004050	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
1248725004051	transcription elongation factor NusA; Provisional; Region: nusA; PRK12328
1248725004052	NusA N-terminal domain; Region: NusA_N; pfam08529
1248725004053	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1248725004054	RNA binding site [nucleotide binding]; other site
1248725004055	homodimer interface [polypeptide binding]; other site
1248725004056	NusA-like KH domain; Region: KH_5; pfam13184
1248725004057	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1248725004058	G-X-X-G motif; other site
1248725004059	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
1248725004060	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1248725004061	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1248725004062	putative active site [active]
1248725004063	putative NTP binding site [chemical binding]; other site
1248725004064	putative nucleic acid binding site [nucleotide binding]; other site
1248725004065	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1248725004066	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1248725004067	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
1248725004068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1248725004069	ABC transporter signature motif; other site
1248725004070	Walker B; other site
1248725004071	D-loop; other site
1248725004072	H-loop/switch region; other site
1248725004073	Restriction endonuclease [Defense mechanisms]; Region: COG3587
1248725004074	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725004075	ATP binding site [chemical binding]; other site
1248725004076	putative Mg++ binding site [ion binding]; other site
1248725004077	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1248725004078	DNA methylase; Region: N6_N4_Mtase; cl17433
1248725004079	DNA methylase; Region: N6_N4_Mtase; pfam01555
1248725004080	DNA methylase; Region: N6_N4_Mtase; cl17433
1248725004081	ATP-dependent DNA helicase RecG; Region: recG; TIGR00643
1248725004082	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1248725004083	ssDNA binding site; other site
1248725004084	generic binding surface II; other site
1248725004085	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725004086	ATP binding site [chemical binding]; other site
1248725004087	putative Mg++ binding site [ion binding]; other site
1248725004088	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725004089	nucleotide binding region [chemical binding]; other site
1248725004090	ATP-binding site [chemical binding]; other site
1248725004091	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725004092	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1248725004093	active site
1248725004094	putative catalytic site [active]
1248725004095	DNA binding site [nucleotide binding]
1248725004096	putative phosphate binding site [ion binding]; other site
1248725004097	metal binding site A [ion binding]; metal-binding site
1248725004098	AP binding site [nucleotide binding]; other site
1248725004099	metal binding site B [ion binding]; metal-binding site
1248725004100	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1248725004101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1248725004102	Walker A motif; other site
1248725004103	ATP binding site [chemical binding]; other site
1248725004104	Walker B motif; other site
1248725004105	arginine finger; other site
1248725004106	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1248725004107	DnaA box-binding interface [nucleotide binding]; other site
1248725004108	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1248725004109	Protein of unknown function (DUF2443); Region: DUF2443; pfam10398
1248725004110	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
1248725004111	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1248725004112	glutaminase active site [active]
1248725004113	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1248725004114	dimer interface [polypeptide binding]; other site
1248725004115	active site
1248725004116	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1248725004117	dimer interface [polypeptide binding]; other site
1248725004118	active site
1248725004119	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
1248725004120	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1248725004121	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725004122	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1248725004123	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1248725004124	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1248725004125	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1248725004126	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1248725004127	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725004128	ATP binding site [chemical binding]; other site
1248725004129	putative Mg++ binding site [ion binding]; other site
1248725004130	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1248725004131	Protein of unknown function DUF45; Region: DUF45; pfam01863
1248725004132	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1248725004133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1248725004134	N-terminal plug; other site
1248725004135	ligand-binding site [chemical binding]; other site
1248725004136	Arginase family; Region: Arginase; cd09989
1248725004137	active site
1248725004138	Mn binding site [ion binding]; other site
1248725004139	oligomer interface [polypeptide binding]; other site
1248725004140	S-methylmethionine transporter; Provisional; Region: PRK11387
1248725004141	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1248725004142	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1248725004143	hexamer interface [polypeptide binding]; other site
1248725004144	ligand binding site [chemical binding]; other site
1248725004145	putative active site [active]
1248725004146	NAD(P) binding site [chemical binding]; other site
1248725004147	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725004148	Protein of unknown function DUF262; Region: DUF262; pfam03235
1248725004149	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1248725004150	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1248725004151	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
1248725004152	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
1248725004153	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1248725004154	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1248725004155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1248725004156	Walker A/P-loop; other site
1248725004157	ATP binding site [chemical binding]; other site
1248725004158	Q-loop/lid; other site
1248725004159	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1248725004160	ABC transporter signature motif; other site
1248725004161	Walker B; other site
1248725004162	D-loop; other site
1248725004163	H-loop/switch region; other site
1248725004164	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1248725004165	DNA polymerase III subunit epsilon; Provisional; Region: PRK08517
1248725004166	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1248725004167	active site
1248725004168	catalytic site [active]
1248725004169	substrate binding site [chemical binding]; other site
1248725004170	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1248725004171	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1248725004172	substrate binding site [chemical binding]; other site
1248725004173	hexamer interface [polypeptide binding]; other site
1248725004174	metal binding site [ion binding]; metal-binding site
1248725004175	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1248725004176	active site
1248725004177	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1248725004178	elongation factor Ts; Provisional; Region: tsf; PRK09377
1248725004179	UBA/TS-N domain; Region: UBA; pfam00627
1248725004180	Elongation factor TS; Region: EF_TS; pfam00889
1248725004181	Elongation factor TS; Region: EF_TS; pfam00889
1248725004182	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1248725004183	rRNA interaction site [nucleotide binding]; other site
1248725004184	S8 interaction site; other site
1248725004185	putative laminin-1 binding site; other site
1248725004186	putative recombination protein RecB; Provisional; Region: PRK13909
1248725004187	Family description; Region: UvrD_C_2; pfam13538
1248725004188	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1248725004189	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856
1248725004190	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1248725004191	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1248725004192	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1248725004193	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
1248725004194	Protein export membrane protein; Region: SecD_SecF; pfam02355
1248725004195	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1248725004196	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1248725004197	HIGH motif; other site
1248725004198	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1248725004199	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1248725004200	active site
1248725004201	KMSKS motif; other site
1248725004202	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1248725004203	tRNA binding surface [nucleotide binding]; other site
1248725004204	anticodon binding site; other site
1248725004205	Lipopolysaccharide-assembly; Region: LptE; pfam04390
1248725004206	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1248725004207	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1248725004208	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1248725004209	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1248725004210	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725004211	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1248725004212	Peptidase family M23; Region: Peptidase_M23; pfam01551
1248725004213	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1248725004214	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1248725004215	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
1248725004216	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1248725004217	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1248725004218	ATP binding site [chemical binding]; other site
1248725004219	putative Mg++ binding site [ion binding]; other site
1248725004220	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1248725004221	nucleotide binding region [chemical binding]; other site
1248725004222	ATP-binding site [chemical binding]; other site
1248725004223	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1248725004224	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1248725004225	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1248725004226	[2Fe-2S] cluster binding site [ion binding]; other site
1248725004227	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1248725004228	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1248725004229	intrachain domain interface; other site
1248725004230	interchain domain interface [polypeptide binding]; other site
1248725004231	heme bH binding site [chemical binding]; other site
1248725004232	Qi binding site; other site
1248725004233	heme bL binding site [chemical binding]; other site
1248725004234	Qo binding site; other site
1248725004235	interchain domain interface [polypeptide binding]; other site
1248725004236	intrachain domain interface; other site
1248725004237	Qi binding site; other site
1248725004238	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1248725004239	Qo binding site; other site
1248725004240	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
1248725004241	Cytochrome c; Region: Cytochrom_C; pfam00034
1248725004242	Cytochrome c; Region: Cytochrom_C; cl11414
1248725004243	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1248725004244	Sulfatase; Region: Sulfatase; pfam00884
1248725004245	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1248725004246	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1248725004247	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1248725004248	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907
1248725004249	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1248725004250	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1248725004251	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1248725004252	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1248725004253	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1248725004254	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1248725004255	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
1248725004256	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1248725004257	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1248725004258	dimer interface [polypeptide binding]; other site
1248725004259	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1248725004260	catalytic triad [active]
1248725004261	peroxidatic and resolving cysteines [active]
1248725004262	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1248725004263	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1248725004264	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1248725004265	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1248725004266	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1248725004267	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1248725004268	G1 box; other site
1248725004269	GTP/Mg2+ binding site [chemical binding]; other site
1248725004270	Switch I region; other site
1248725004271	G2 box; other site
1248725004272	G3 box; other site
1248725004273	Switch II region; other site
1248725004274	G4 box; other site
1248725004275	G5 box; other site
1248725004276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
1248725004277	OstA-like protein; Region: OstA; pfam03968
1248725004278	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1248725004279	motif II; other site
1248725004280	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1248725004281	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1248725004282	Sporulation related domain; Region: SPOR; pfam05036
1248725004283	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1248725004284	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1248725004285	catalytic residue [active]
1248725004286	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1248725004287	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1248725004288	active site
1248725004289	riboflavin synthase, alpha subunit; Region: ribE; TIGR00187
1248725004290	Lumazine binding domain; Region: Lum_binding; pfam00677
1248725004291	Lumazine binding domain; Region: Lum_binding; pfam00677
1248725004292	flhB C-terminus-related protein; Region: flhB_rel; TIGR00789
1248725004293	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1248725004294	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1248725004295	Walker A/P-loop; other site
1248725004296	ATP binding site [chemical binding]; other site
1248725004297	Q-loop/lid; other site
1248725004298	ABC transporter signature motif; other site
1248725004299	Walker B; other site
1248725004300	D-loop; other site
1248725004301	H-loop/switch region; other site
1248725004302	NIL domain; Region: NIL; pfam09383
1248725004303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1248725004304	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1248725004305	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
1248725004306	active site
1248725004307	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1248725004308	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
1248725004309	Mg++ binding site [ion binding]; other site
1248725004310	putative catalytic motif [active]
1248725004311	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1248725004312	active site
1248725004313	hydrophilic channel; other site
1248725004314	dimerization interface [polypeptide binding]; other site
1248725004315	catalytic residues [active]
1248725004316	active site lid [active]
1248725004317	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1248725004318	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946
1248725004319	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1248725004320	metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329
1248725004321	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1248725004322	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1248725004323	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1248725004324	hypothetical protein; Provisional; Region: PRK10236
1248725004325	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
1248725004326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735