-- dump date 20140619_114028 -- class Genbank::misc_feature -- table misc_feature_note -- id note 794851000001 Initiator Replication protein; Region: Rep_3; pfam01051 794851000002 Fic family protein [Function unknown]; Region: COG3177 794851000003 Fic/DOC family; Region: Fic; pfam02661 794851000004 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 794851000005 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 794851000006 putative RNA binding site [nucleotide binding]; other site 794851000007 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 794851000008 homopentamer interface [polypeptide binding]; other site 794851000009 active site 794851000010 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 794851000011 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 794851000012 active site clefts [active] 794851000013 zinc binding site [ion binding]; other site 794851000014 dimer interface [polypeptide binding]; other site 794851000015 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 794851000016 active site 794851000017 dimer interface [polypeptide binding]; other site 794851000018 pantoate--beta-alanine ligase; Region: panC; TIGR00018 794851000019 Pantoate-beta-alanine ligase; Region: PanC; cd00560 794851000020 active site 794851000021 ATP-binding site [chemical binding]; other site 794851000022 pantoate-binding site; other site 794851000023 HXXH motif; other site 794851000024 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 794851000025 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 794851000026 ring oligomerisation interface [polypeptide binding]; other site 794851000027 ATP/Mg binding site [chemical binding]; other site 794851000028 stacking interactions; other site 794851000029 hinge regions; other site 794851000030 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 794851000031 oligomerisation interface [polypeptide binding]; other site 794851000032 mobile loop; other site 794851000033 roof hairpin; other site 794851000034 DNA primase, catalytic core; Region: dnaG; TIGR01391 794851000035 CHC2 zinc finger; Region: zf-CHC2; pfam01807 794851000036 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 794851000037 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 794851000038 active site 794851000039 metal binding site [ion binding]; metal-binding site 794851000040 interdomain interaction site; other site 794851000041 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 794851000042 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 794851000043 Ligand Binding Site [chemical binding]; other site 794851000044 TrbC/VIRB2 family; Region: TrbC; cl01583 794851000045 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 794851000046 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 794851000047 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 794851000048 Walker A motif; other site 794851000049 ATP binding site [chemical binding]; other site 794851000050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 794851000051 Walker B motif; other site 794851000052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 794851000053 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 794851000054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 794851000055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851000056 active site 794851000057 phosphorylation site [posttranslational modification] 794851000058 intermolecular recognition site; other site 794851000059 dimerization interface [polypeptide binding]; other site 794851000060 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 794851000061 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 794851000062 dimer interface [polypeptide binding]; other site 794851000063 active site 794851000064 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 794851000065 catalytic residues [active] 794851000066 substrate binding site [chemical binding]; other site 794851000067 lipid A 1-phosphatase; Reviewed; Region: PRK09597 794851000068 active site 794851000069 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 794851000070 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 794851000071 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 794851000072 Sulfatase; Region: Sulfatase; pfam00884 794851000073 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000074 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 794851000075 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 794851000076 dimer interface [polypeptide binding]; other site 794851000077 active site 794851000078 citrylCoA binding site [chemical binding]; other site 794851000079 NADH binding [chemical binding]; other site 794851000080 cationic pore residues; other site 794851000081 oxalacetate/citrate binding site [chemical binding]; other site 794851000082 coenzyme A binding site [chemical binding]; other site 794851000083 catalytic triad [active] 794851000084 isocitrate dehydrogenase; Validated; Region: PRK07362 794851000085 isocitrate dehydrogenase; Reviewed; Region: PRK07006 794851000086 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 794851000087 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 794851000088 AAA domain; Region: AAA_26; pfam13500 794851000089 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 794851000090 Ligand Binding Site [chemical binding]; other site 794851000091 Uncharacterized conserved protein [Function unknown]; Region: COG2127 794851000092 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 794851000093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851000094 Walker A motif; other site 794851000095 ATP binding site [chemical binding]; other site 794851000096 Walker B motif; other site 794851000097 arginine finger; other site 794851000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851000099 Walker A motif; other site 794851000100 ATP binding site [chemical binding]; other site 794851000101 Walker B motif; other site 794851000102 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 794851000103 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 794851000104 tetramerization interface [polypeptide binding]; other site 794851000105 active site 794851000106 hypothetical protein; Provisional; Region: PRK03762 794851000107 PDZ domain; Region: PDZ_2; pfam13180 794851000108 protein binding site [polypeptide binding]; other site 794851000109 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 794851000110 Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846 794851000111 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 794851000112 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 794851000113 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 794851000114 VirB7 interaction site; other site 794851000115 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 794851000116 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 794851000117 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 794851000118 Substrate binding site; other site 794851000119 Cupin domain; Region: Cupin_2; cl17218 794851000120 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 794851000121 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 794851000122 NADP-binding site; other site 794851000123 homotetramer interface [polypeptide binding]; other site 794851000124 substrate binding site [chemical binding]; other site 794851000125 homodimer interface [polypeptide binding]; other site 794851000126 active site 794851000127 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 794851000128 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 794851000129 NADP binding site [chemical binding]; other site 794851000130 active site 794851000131 putative substrate binding site [chemical binding]; other site 794851000132 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 794851000133 dimerization interface [polypeptide binding]; other site 794851000134 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 794851000135 ATP binding site [chemical binding]; other site 794851000136 Acylphosphatase; Region: Acylphosphatase; pfam00708 794851000137 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 794851000138 HypF finger; Region: zf-HYPF; pfam07503 794851000139 HypF finger; Region: zf-HYPF; pfam07503 794851000140 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 794851000141 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957 794851000142 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 794851000143 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 794851000144 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000145 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 794851000146 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851000147 cofactor binding site; other site 794851000148 DNA binding site [nucleotide binding] 794851000149 substrate interaction site [chemical binding]; other site 794851000150 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851000151 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 794851000152 active site 794851000153 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851000154 cofactor binding site; other site 794851000155 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 794851000156 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 794851000157 Na binding site [ion binding]; other site 794851000158 Proline dehydrogenase; Region: Pro_dh; pfam01619 794851000159 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 794851000160 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 794851000161 Glutamate binding site [chemical binding]; other site 794851000162 NAD binding site [chemical binding]; other site 794851000163 catalytic residues [active] 794851000164 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 794851000165 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 794851000166 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 794851000167 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 794851000168 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 794851000169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 794851000170 G1 box; other site 794851000171 GTP/Mg2+ binding site [chemical binding]; other site 794851000172 G2 box; other site 794851000173 Switch I region; other site 794851000174 G3 box; other site 794851000175 Switch II region; other site 794851000176 G4 box; other site 794851000177 G5 box; other site 794851000178 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 794851000179 UreF; Region: UreF; pfam01730 794851000180 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 794851000181 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 794851000182 dimer interface [polypeptide binding]; other site 794851000183 catalytic residues [active] 794851000184 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 794851000185 urease subunit beta; Provisional; Region: ureB; PRK13985 794851000186 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 794851000187 subunit interactions [polypeptide binding]; other site 794851000188 active site 794851000189 flap region; other site 794851000190 urease subunit alpha; Provisional; Region: PRK13986 794851000191 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 794851000192 alpha-gamma subunit interface [polypeptide binding]; other site 794851000193 beta-gamma subunit interface [polypeptide binding]; other site 794851000194 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 794851000195 gamma-beta subunit interface [polypeptide binding]; other site 794851000196 alpha-beta subunit interface [polypeptide binding]; other site 794851000197 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 794851000198 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 794851000199 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 794851000200 active site 794851000201 substrate binding site [chemical binding]; other site 794851000202 metal binding site [ion binding]; metal-binding site 794851000203 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 794851000204 peptide chain release factor 1; Validated; Region: prfA; PRK00591 794851000205 This domain is found in peptide chain release factors; Region: PCRF; smart00937 794851000206 RF-1 domain; Region: RF-1; pfam00472 794851000207 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 794851000209 dimer interface [polypeptide binding]; other site 794851000210 putative CheW interface [polypeptide binding]; other site 794851000211 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 794851000212 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 794851000213 23S rRNA interface [nucleotide binding]; other site 794851000214 L3 interface [polypeptide binding]; other site 794851000215 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 794851000216 Predicted dehydrogenase [General function prediction only]; Region: COG0579 794851000217 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 794851000218 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 794851000219 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 794851000220 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 794851000221 NlpC/P60 family; Region: NLPC_P60; pfam00877 794851000222 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 794851000223 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 794851000224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 794851000225 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 794851000226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 794851000227 DNA binding residues [nucleotide binding] 794851000228 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 794851000229 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 794851000230 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 794851000231 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 794851000232 potential protein location (hypothetical protein HPSAT_00420 [Helicobacter pylori Sat464]) that overlaps RNA (tRNA-S) 794851000233 DpnII restriction endonuclease; Region: DpnII; pfam04556 794851000234 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 794851000235 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851000236 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000237 potential frameshift: common BLAST hit: gi|188526899|ref|YP_001909586.1| alpha-1,2-fucosyltransferase 794851000238 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 794851000239 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 794851000240 putative ligand binding site [chemical binding]; other site 794851000241 putative NAD binding site [chemical binding]; other site 794851000242 catalytic site [active] 794851000243 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 794851000244 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 794851000245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851000246 catalytic residue [active] 794851000247 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 794851000248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 794851000249 dimer interface [polypeptide binding]; other site 794851000250 putative CheW interface [polypeptide binding]; other site 794851000251 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 794851000252 Ligand Binding Site [chemical binding]; other site 794851000253 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 794851000255 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 794851000256 metal-binding site 794851000257 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 794851000258 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 794851000259 dimerization interface [polypeptide binding]; other site 794851000260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 794851000261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 794851000262 dimer interface [polypeptide binding]; other site 794851000263 putative CheW interface [polypeptide binding]; other site 794851000264 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 794851000265 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 794851000266 active site 794851000267 metal binding site [ion binding]; metal-binding site 794851000268 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 794851000269 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 794851000270 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 794851000271 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 794851000272 homodimer interface [polypeptide binding]; other site 794851000273 substrate-cofactor binding pocket; other site 794851000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851000275 catalytic residue [active] 794851000276 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 794851000277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 794851000278 dimer interface [polypeptide binding]; other site 794851000279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851000280 catalytic residue [active] 794851000281 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 794851000282 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 794851000283 nucleotide binding site [chemical binding]; other site 794851000284 NEF interaction site [polypeptide binding]; other site 794851000285 SBD interface [polypeptide binding]; other site 794851000286 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 794851000287 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 794851000288 dimer interface [polypeptide binding]; other site 794851000289 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 794851000290 heat-inducible transcription repressor; Provisional; Region: PRK03911 794851000291 hypothetical protein; Provisional; Region: PRK05834 794851000292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 794851000293 flagellin B; Provisional; Region: PRK13588 794851000294 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 794851000295 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 794851000296 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 794851000297 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 794851000298 DNA topoisomerase I; Validated; Region: PRK05582 794851000299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 794851000300 active site 794851000301 interdomain interaction site; other site 794851000302 putative metal-binding site [ion binding]; other site 794851000303 nucleotide binding site [chemical binding]; other site 794851000304 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 794851000305 domain I; other site 794851000306 DNA binding groove [nucleotide binding] 794851000307 phosphate binding site [ion binding]; other site 794851000308 domain II; other site 794851000309 domain III; other site 794851000310 nucleotide binding site [chemical binding]; other site 794851000311 catalytic site [active] 794851000312 domain IV; other site 794851000313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 794851000314 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 794851000315 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 794851000316 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 794851000317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851000318 FeS/SAM binding site; other site 794851000319 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 794851000320 Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917 794851000321 phosphoenolpyruvate synthase; Validated; Region: PRK06464 794851000322 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 794851000323 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 794851000324 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 794851000325 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 794851000326 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 794851000327 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 794851000328 active site 794851000329 dimer interface [polypeptide binding]; other site 794851000330 motif 1; other site 794851000331 motif 2; other site 794851000332 motif 3; other site 794851000333 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 794851000334 anticodon binding site; other site 794851000335 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 794851000336 translation initiation factor IF-3; Region: infC; TIGR00168 794851000337 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 794851000338 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 794851000339 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 794851000340 23S rRNA binding site [nucleotide binding]; other site 794851000341 L21 binding site [polypeptide binding]; other site 794851000342 L13 binding site [polypeptide binding]; other site 794851000343 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000344 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 794851000345 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 794851000346 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 794851000347 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 794851000348 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 794851000349 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 794851000350 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 794851000351 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 794851000352 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 794851000353 catalytic triad [active] 794851000354 Uncharacterized conserved protein [Function unknown]; Region: COG1556 794851000355 iron-sulfur cluster-binding protein; Region: TIGR00273 794851000356 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 794851000357 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 794851000358 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 794851000359 Cysteine-rich domain; Region: CCG; pfam02754 794851000360 Cysteine-rich domain; Region: CCG; pfam02754 794851000361 L-lactate transport; Region: lctP; TIGR00795 794851000362 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 794851000363 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 794851000364 L-lactate transport; Region: lctP; TIGR00795 794851000365 DNA glycosylase MutY; Provisional; Region: PRK13910 794851000366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 794851000367 minor groove reading motif; other site 794851000368 helix-hairpin-helix signature motif; other site 794851000369 substrate binding pocket [chemical binding]; other site 794851000370 active site 794851000371 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 794851000372 DNA binding and oxoG recognition site [nucleotide binding] 794851000373 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 794851000374 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 794851000375 transmembrane helices; other site 794851000376 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 794851000377 Low-spin heme binding site [chemical binding]; other site 794851000378 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 794851000379 D-pathway; other site 794851000380 Putative water exit pathway; other site 794851000381 Binuclear center (active site) [active] 794851000382 K-pathway; other site 794851000383 Putative proton exit pathway; other site 794851000384 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 794851000385 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 794851000386 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 794851000387 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 794851000388 Cytochrome c; Region: Cytochrom_C; pfam00034 794851000389 Cytochrome c; Region: Cytochrom_C; pfam00034 794851000390 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 794851000391 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 794851000392 recombinase A; Provisional; Region: recA; PRK09354 794851000393 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 794851000394 hexamer interface [polypeptide binding]; other site 794851000395 Walker A motif; other site 794851000396 ATP binding site [chemical binding]; other site 794851000397 Walker B motif; other site 794851000398 enolase; Provisional; Region: eno; PRK00077 794851000399 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 794851000400 dimer interface [polypeptide binding]; other site 794851000401 metal binding site [ion binding]; metal-binding site 794851000402 substrate binding pocket [chemical binding]; other site 794851000403 AMIN domain; Region: AMIN; pfam11741 794851000404 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 794851000405 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 794851000406 ADP binding site [chemical binding]; other site 794851000407 magnesium binding site [ion binding]; other site 794851000408 putative shikimate binding site; other site 794851000409 Cache domain; Region: Cache_1; pfam02743 794851000410 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851000411 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 794851000412 Ligand binding site; other site 794851000413 metal-binding site 794851000414 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851000415 Sel1-like repeats; Region: SEL1; smart00671 794851000416 Sel1-like repeats; Region: SEL1; smart00671 794851000417 Sel1-like repeats; Region: SEL1; smart00671 794851000418 Sel1-like repeats; Region: SEL1; smart00671 794851000419 Sel1 repeat; Region: Sel1; cl02723 794851000420 Sel1-like repeats; Region: SEL1; smart00671 794851000421 hypothetical protein; Provisional; Region: PRK12378 794851000422 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 794851000423 dimer interface [polypeptide binding]; other site 794851000424 active site 794851000425 Schiff base residues; other site 794851000426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 794851000427 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 794851000428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 794851000429 dimer interface [polypeptide binding]; other site 794851000430 phosphorylation site [posttranslational modification] 794851000431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851000432 ATP binding site [chemical binding]; other site 794851000433 Mg2+ binding site [ion binding]; other site 794851000434 G-X-G motif; other site 794851000435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 794851000436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851000437 active site 794851000438 phosphorylation site [posttranslational modification] 794851000439 intermolecular recognition site; other site 794851000440 dimerization interface [polypeptide binding]; other site 794851000441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 794851000442 DNA binding site [nucleotide binding] 794851000443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 794851000444 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 794851000445 Peptidase family U32; Region: Peptidase_U32; pfam01136 794851000446 peptide chain release factor 2; Region: prfB; TIGR00020 794851000447 This domain is found in peptide chain release factors; Region: PCRF; smart00937 794851000448 RF-1 domain; Region: RF-1; pfam00472 794851000449 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 794851000450 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 794851000451 dimer interface [polypeptide binding]; other site 794851000452 putative functional site; other site 794851000453 putative MPT binding site; other site 794851000454 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 794851000455 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 794851000456 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 794851000457 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 794851000458 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 794851000459 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 794851000460 intersubunit interface [polypeptide binding]; other site 794851000461 active site 794851000462 zinc binding site [ion binding]; other site 794851000463 Na+ binding site [ion binding]; other site 794851000464 elongation factor P; Validated; Region: PRK00529 794851000465 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 794851000466 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 794851000467 RNA binding site [nucleotide binding]; other site 794851000468 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 794851000469 RNA binding site [nucleotide binding]; other site 794851000470 pseudaminic acid synthase; Region: PseI; TIGR03586 794851000471 NeuB family; Region: NeuB; pfam03102 794851000472 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 794851000473 NeuB binding interface [polypeptide binding]; other site 794851000474 putative substrate binding site [chemical binding]; other site 794851000475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 794851000476 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 794851000477 Walker A/P-loop; other site 794851000478 ATP binding site [chemical binding]; other site 794851000479 Q-loop/lid; other site 794851000480 ABC transporter signature motif; other site 794851000481 Walker B; other site 794851000482 D-loop; other site 794851000483 H-loop/switch region; other site 794851000484 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 794851000485 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 794851000486 active site 794851000487 catalytic triad [active] 794851000488 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 794851000489 Colicin V production protein; Region: Colicin_V; pfam02674 794851000490 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 794851000491 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 794851000492 dimer interface [polypeptide binding]; other site 794851000493 putative anticodon binding site; other site 794851000494 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 794851000495 motif 1; other site 794851000496 active site 794851000497 motif 2; other site 794851000498 motif 3; other site 794851000499 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 794851000500 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 794851000501 dimer interface [polypeptide binding]; other site 794851000502 active site 794851000503 glycine-pyridoxal phosphate binding site [chemical binding]; other site 794851000504 folate binding site [chemical binding]; other site 794851000505 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 794851000506 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 794851000507 Protein of unknown function DUF262; Region: DUF262; pfam03235 794851000508 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 794851000509 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 794851000510 PLD-like domain; Region: PLDc_2; pfam13091 794851000511 putative active site [active] 794851000512 catalytic site [active] 794851000513 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 794851000514 PLD-like domain; Region: PLDc_2; pfam13091 794851000515 putative active site [active] 794851000516 catalytic site [active] 794851000517 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 794851000518 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 794851000519 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 794851000520 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 794851000521 L-aspartate oxidase; Provisional; Region: PRK06175 794851000522 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 794851000523 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 794851000524 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 794851000525 Iron-sulfur protein interface; other site 794851000526 proximal heme binding site [chemical binding]; other site 794851000527 distal heme binding site [chemical binding]; other site 794851000528 dimer interface [polypeptide binding]; other site 794851000529 triosephosphate isomerase; Provisional; Region: PRK14567 794851000530 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 794851000531 substrate binding site [chemical binding]; other site 794851000532 dimer interface [polypeptide binding]; other site 794851000533 catalytic triad [active] 794851000534 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 794851000535 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 794851000536 NAD binding site [chemical binding]; other site 794851000537 homotetramer interface [polypeptide binding]; other site 794851000538 homodimer interface [polypeptide binding]; other site 794851000539 substrate binding site [chemical binding]; other site 794851000540 active site 794851000541 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 794851000542 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 794851000543 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 794851000544 trimer interface [polypeptide binding]; other site 794851000545 active site 794851000546 UDP-GlcNAc binding site [chemical binding]; other site 794851000547 lipid binding site [chemical binding]; lipid-binding site 794851000548 S-adenosylmethionine synthetase; Validated; Region: PRK05250 794851000549 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 794851000550 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 794851000551 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 794851000552 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 794851000553 active site 794851000554 multimer interface [polypeptide binding]; other site 794851000555 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 794851000556 fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182 794851000557 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 794851000558 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 794851000559 dimer interface [polypeptide binding]; other site 794851000560 active site 794851000561 CoA binding pocket [chemical binding]; other site 794851000562 antiporter inner membrane protein; Provisional; Region: PRK11670 794851000563 Domain of unknown function DUF59; Region: DUF59; pfam01883 794851000564 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 794851000565 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851000566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 794851000567 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851000568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 794851000569 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851000570 heat shock protein 90; Provisional; Region: PRK05218 794851000571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851000572 ATP binding site [chemical binding]; other site 794851000573 Mg2+ binding site [ion binding]; other site 794851000574 G-X-G motif; other site 794851000575 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851000576 Sel1-like repeats; Region: SEL1; smart00671 794851000577 Sel1-like repeats; Region: SEL1; smart00671 794851000578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851000579 TPR motif; other site 794851000580 binding surface 794851000581 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 794851000582 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 794851000583 metal binding site [ion binding]; metal-binding site 794851000584 dimer interface [polypeptide binding]; other site 794851000585 glucose-inhibited division protein A; Region: gidA; TIGR00136 794851000586 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 794851000587 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 794851000588 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 794851000589 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 794851000590 transmembrane helices; other site 794851000591 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 794851000592 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 794851000593 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 794851000594 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 794851000595 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 794851000596 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 794851000597 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 794851000598 substrate binding site [chemical binding]; other site 794851000599 Helix-turn-helix domain; Region: HTH_28; pfam13518 794851000600 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 794851000601 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 794851000602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 794851000603 catalytic residue [active] 794851000604 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 794851000605 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 794851000606 trimerization site [polypeptide binding]; other site 794851000607 active site 794851000608 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 794851000609 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 794851000610 DNA repair protein RadA; Region: sms; TIGR00416 794851000611 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 794851000612 Walker A motif/ATP binding site; other site 794851000613 ATP binding site [chemical binding]; other site 794851000614 Walker B motif; other site 794851000615 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 794851000616 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 794851000617 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 794851000618 SelR domain; Region: SelR; pfam01641 794851000619 Predicted permeases [General function prediction only]; Region: COG0730 794851000620 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000621 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 794851000622 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 794851000623 Sulfate transporter family; Region: Sulfate_transp; pfam00916 794851000624 potential protein location (hypothetical protein HPSAT_01140 [Helicobacter pylori Sat464]) that overlaps RNA (tRNA-N) 794851000625 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000626 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 794851000627 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 794851000628 Ligand binding site; other site 794851000629 oligomer interface; other site 794851000630 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 794851000631 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 794851000632 hypothetical protein; Provisional; Region: PRK04081 794851000633 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 794851000634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 794851000635 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851000636 Sel1-like repeats; Region: SEL1; smart00671 794851000637 Sel1-like repeats; Region: SEL1; smart00671 794851000638 Sel1-like repeats; Region: SEL1; smart00671 794851000639 Sel1-like repeats; Region: SEL1; smart00671 794851000640 Sel1-like repeats; Region: SEL1; smart00671 794851000641 Cytochrome c; Region: Cytochrom_C; cl11414 794851000642 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 794851000643 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 794851000644 domain interfaces; other site 794851000645 active site 794851000646 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 794851000647 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 794851000648 dimer interface [polypeptide binding]; other site 794851000649 motif 1; other site 794851000650 active site 794851000651 motif 2; other site 794851000652 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 794851000653 putative deacylase active site [active] 794851000654 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 794851000655 active site 794851000656 motif 3; other site 794851000657 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 794851000658 anticodon binding site; other site 794851000659 glutamyl-tRNA reductase; Region: hemA; TIGR01035 794851000660 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 794851000661 tRNA; other site 794851000662 putative tRNA binding site [nucleotide binding]; other site 794851000663 putative NADP binding site [chemical binding]; other site 794851000664 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 794851000665 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 794851000666 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 794851000667 substrate binding pocket [chemical binding]; other site 794851000668 chain length determination region; other site 794851000669 substrate-Mg2+ binding site; other site 794851000670 catalytic residues [active] 794851000671 aspartate-rich region 1; other site 794851000672 active site lid residues [active] 794851000673 aspartate-rich region 2; other site 794851000674 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 794851000675 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 794851000676 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 794851000677 dimerization interface [polypeptide binding]; other site 794851000678 DPS ferroxidase diiron center [ion binding]; other site 794851000679 ion pore; other site 794851000680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 794851000681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 794851000682 dimer interface [polypeptide binding]; other site 794851000683 phosphorylation site [posttranslational modification] 794851000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851000685 ATP binding site [chemical binding]; other site 794851000686 Mg2+ binding site [ion binding]; other site 794851000687 G-X-G motif; other site 794851000688 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 794851000689 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 794851000690 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 794851000691 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 794851000692 ATP binding site [chemical binding]; other site 794851000693 Mg++ binding site [ion binding]; other site 794851000694 motif III; other site 794851000695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851000696 nucleotide binding region [chemical binding]; other site 794851000697 ATP-binding site [chemical binding]; other site 794851000698 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 794851000699 SPFH domain / Band 7 family; Region: Band_7; pfam01145 794851000700 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 794851000701 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 794851000702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 794851000703 Walker A/P-loop; other site 794851000704 ATP binding site [chemical binding]; other site 794851000705 Q-loop/lid; other site 794851000706 ABC transporter signature motif; other site 794851000707 Walker B; other site 794851000708 D-loop; other site 794851000709 H-loop/switch region; other site 794851000710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 794851000711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 794851000712 Walker A/P-loop; other site 794851000713 ATP binding site [chemical binding]; other site 794851000714 Q-loop/lid; other site 794851000715 ABC transporter signature motif; other site 794851000716 Walker B; other site 794851000717 D-loop; other site 794851000718 H-loop/switch region; other site 794851000719 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 794851000720 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 794851000721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851000722 dimer interface [polypeptide binding]; other site 794851000723 conserved gate region; other site 794851000724 putative PBP binding loops; other site 794851000725 ABC-ATPase subunit interface; other site 794851000726 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000727 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000728 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 794851000729 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 794851000730 GDP-binding site [chemical binding]; other site 794851000731 ACT binding site; other site 794851000732 IMP binding site; other site 794851000733 Flagellar FliJ protein; Region: FliJ; pfam02050 794851000734 Uncharacterized conserved protein [Function unknown]; Region: COG3334 794851000735 RIP metalloprotease RseP; Region: TIGR00054 794851000736 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 794851000737 active site 794851000738 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 794851000739 protein binding site [polypeptide binding]; other site 794851000740 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 794851000741 putative substrate binding region [chemical binding]; other site 794851000742 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 794851000743 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 794851000744 generic binding surface II; other site 794851000745 generic binding surface I; other site 794851000746 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 794851000747 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000748 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000749 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 794851000750 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000751 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 794851000752 Clp amino terminal domain; Region: Clp_N; pfam02861 794851000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851000754 Walker A motif; other site 794851000755 ATP binding site [chemical binding]; other site 794851000756 Walker B motif; other site 794851000757 arginine finger; other site 794851000758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851000759 Walker A motif; other site 794851000760 ATP binding site [chemical binding]; other site 794851000761 Walker B motif; other site 794851000762 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 794851000763 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 794851000764 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 794851000765 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 794851000766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 794851000767 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 794851000768 active site 794851000769 chlorohydrolase; Provisional; Region: PRK08418 794851000770 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 794851000771 active site 794851000772 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 794851000773 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 794851000774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851000775 FeS/SAM binding site; other site 794851000776 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 794851000777 putative acyl-acceptor binding pocket; other site 794851000778 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 794851000779 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 794851000780 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 794851000781 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 794851000782 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 794851000783 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 794851000784 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 794851000785 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 794851000786 putative active site [active] 794851000787 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 794851000788 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 794851000789 putative acyl-acceptor binding pocket; other site 794851000790 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 794851000791 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 794851000792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 794851000793 TrkA-C domain; Region: TrkA_C; pfam02080 794851000794 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 794851000795 active site 794851000796 dimer interface [polypeptide binding]; other site 794851000797 metal binding site [ion binding]; metal-binding site 794851000798 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 794851000799 Mechanosensitive ion channel; Region: MS_channel; pfam00924 794851000800 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 794851000801 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 794851000802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851000803 FeS/SAM binding site; other site 794851000804 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 794851000805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851000806 Walker A motif; other site 794851000807 ATP binding site [chemical binding]; other site 794851000808 Walker B motif; other site 794851000809 arginine finger; other site 794851000810 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 794851000811 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851000812 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851000813 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 794851000814 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851000815 Autotransporter beta-domain; Region: Autotransporter; pfam03797 794851000816 diaminopimelate decarboxylase; Region: lysA; TIGR01048 794851000817 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 794851000818 active site 794851000819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 794851000820 substrate binding site [chemical binding]; other site 794851000821 catalytic residues [active] 794851000822 dimer interface [polypeptide binding]; other site 794851000823 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 794851000824 Uncharacterized conserved protein [Function unknown]; Region: COG4866 794851000825 aminodeoxychorismate synthase; Provisional; Region: PRK07508 794851000826 chorismate binding enzyme; Region: Chorismate_bind; cl10555 794851000827 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 794851000828 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 794851000829 substrate-cofactor binding pocket; other site 794851000830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851000831 catalytic residue [active] 794851000832 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 794851000833 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 794851000834 multimer interface [polypeptide binding]; other site 794851000835 active site 794851000836 catalytic triad [active] 794851000837 dimer interface [polypeptide binding]; other site 794851000838 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412 794851000839 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 794851000840 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 794851000841 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 794851000842 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 794851000843 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 794851000844 peptide binding site [polypeptide binding]; other site 794851000845 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 794851000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851000847 dimer interface [polypeptide binding]; other site 794851000848 conserved gate region; other site 794851000849 putative PBP binding loops; other site 794851000850 ABC-ATPase subunit interface; other site 794851000851 dipeptide transporter; Provisional; Region: PRK10913 794851000852 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 794851000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851000854 dimer interface [polypeptide binding]; other site 794851000855 conserved gate region; other site 794851000856 putative PBP binding loops; other site 794851000857 ABC-ATPase subunit interface; other site 794851000858 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 794851000859 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 794851000860 Walker A/P-loop; other site 794851000861 ATP binding site [chemical binding]; other site 794851000862 Q-loop/lid; other site 794851000863 ABC transporter signature motif; other site 794851000864 Walker B; other site 794851000865 D-loop; other site 794851000866 H-loop/switch region; other site 794851000867 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 794851000868 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 794851000869 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 794851000870 Walker A/P-loop; other site 794851000871 ATP binding site [chemical binding]; other site 794851000872 Q-loop/lid; other site 794851000873 ABC transporter signature motif; other site 794851000874 Walker B; other site 794851000875 D-loop; other site 794851000876 H-loop/switch region; other site 794851000877 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 794851000878 GTPase CgtA; Reviewed; Region: obgE; PRK12299 794851000879 GTP1/OBG; Region: GTP1_OBG; pfam01018 794851000880 Obg GTPase; Region: Obg; cd01898 794851000881 G1 box; other site 794851000882 GTP/Mg2+ binding site [chemical binding]; other site 794851000883 Switch I region; other site 794851000884 G2 box; other site 794851000885 G3 box; other site 794851000886 Switch II region; other site 794851000887 G4 box; other site 794851000888 G5 box; other site 794851000889 Alginate lyase; Region: Alginate_lyase; pfam05426 794851000890 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 794851000891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 794851000892 inhibitor-cofactor binding pocket; inhibition site 794851000893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851000894 catalytic residue [active] 794851000895 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 794851000896 Predicted amidohydrolase [General function prediction only]; Region: COG0388 794851000897 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 794851000898 active site 794851000899 catalytic triad [active] 794851000900 dimer interface [polypeptide binding]; other site 794851000901 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 794851000902 active site 794851000903 catalytic site [active] 794851000904 Zn binding site [ion binding]; other site 794851000905 tetramer interface [polypeptide binding]; other site 794851000906 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 794851000907 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 794851000908 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851000909 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 794851000910 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 794851000911 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 794851000912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851000913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 794851000914 putative substrate translocation pore; other site 794851000915 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 794851000916 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 794851000917 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 794851000918 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 794851000919 arginyl-tRNA synthetase; Region: argS; TIGR00456 794851000920 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 794851000921 active site 794851000922 HIGH motif; other site 794851000923 KMSK motif region; other site 794851000924 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 794851000925 tRNA binding surface [nucleotide binding]; other site 794851000926 anticodon binding site; other site 794851000927 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 794851000928 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 794851000929 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 794851000930 catalytic site [active] 794851000931 G-X2-G-X-G-K; other site 794851000932 nuclease NucT; Provisional; Region: PRK13912 794851000933 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 794851000934 putative active site [active] 794851000935 catalytic site [active] 794851000936 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851000937 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 794851000938 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 794851000939 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 794851000940 ligand binding site; other site 794851000941 tetramer interface; other site 794851000942 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 794851000943 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 794851000944 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 794851000945 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 794851000946 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 794851000947 NAD synthetase; Provisional; Region: PRK13980 794851000948 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 794851000949 homodimer interface [polypeptide binding]; other site 794851000950 NAD binding pocket [chemical binding]; other site 794851000951 ATP binding pocket [chemical binding]; other site 794851000952 Mg binding site [ion binding]; other site 794851000953 active-site loop [active] 794851000954 ketol-acid reductoisomerase; Provisional; Region: PRK05479 794851000955 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 794851000956 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 794851000957 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 794851000958 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 794851000959 Switch I; other site 794851000960 Switch II; other site 794851000961 cell division topological specificity factor MinE; Region: minE; TIGR01215 794851000962 DNA protecting protein DprA; Region: dprA; TIGR00732 794851000963 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 794851000964 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 794851000965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851000966 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851000967 TPR motif; other site 794851000968 binding surface 794851000969 Sel1-like repeats; Region: SEL1; smart00671 794851000970 chlorohydrolase; Provisional; Region: PRK07213 794851000971 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 794851000972 catalytic residue [active] 794851000973 Predicted membrane protein [Function unknown]; Region: COG3326 794851000974 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 794851000975 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 794851000976 active site 794851000977 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 794851000978 DHH family; Region: DHH; pfam01368 794851000979 DHHA1 domain; Region: DHHA1; pfam02272 794851000980 CTP synthetase; Validated; Region: pyrG; PRK05380 794851000981 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 794851000982 Catalytic site [active] 794851000983 active site 794851000984 UTP binding site [chemical binding]; other site 794851000985 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 794851000986 active site 794851000987 putative oxyanion hole; other site 794851000988 catalytic triad [active] 794851000989 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 794851000990 active site 794851000991 potential frameshift: common BLAST hit: gi|188527156|ref|YP_001909843.1| flagellar MS-ring protein 794851000992 flagellar motor switch protein FliG; Region: fliG; TIGR00207 794851000993 FliG C-terminal domain; Region: FliG_C; pfam01706 794851000994 flagellar assembly protein H; Validated; Region: fliH; PRK06669 794851000995 Flagellar assembly protein FliH; Region: FliH; pfam02108 794851000996 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 794851000997 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 794851000998 TPP-binding site; other site 794851000999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 794851001000 PYR/PP interface [polypeptide binding]; other site 794851001001 dimer interface [polypeptide binding]; other site 794851001002 TPP binding site [chemical binding]; other site 794851001003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 794851001004 GTP-binding protein LepA; Provisional; Region: PRK05433 794851001005 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 794851001006 G1 box; other site 794851001007 putative GEF interaction site [polypeptide binding]; other site 794851001008 GTP/Mg2+ binding site [chemical binding]; other site 794851001009 Switch I region; other site 794851001010 G2 box; other site 794851001011 G3 box; other site 794851001012 Switch II region; other site 794851001013 G4 box; other site 794851001014 G5 box; other site 794851001015 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 794851001016 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 794851001017 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 794851001018 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851001019 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 794851001020 cofactor binding site; other site 794851001021 DNA binding site [nucleotide binding] 794851001022 substrate interaction site [chemical binding]; other site 794851001023 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 794851001024 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 794851001025 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 794851001026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851001027 putative substrate translocation pore; other site 794851001028 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 794851001029 TspO/MBR family; Region: TspO_MBR; cl01379 794851001030 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 794851001031 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 794851001032 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 794851001033 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 794851001034 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 794851001035 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 794851001036 TPP-binding site [chemical binding]; other site 794851001037 dimer interface [polypeptide binding]; other site 794851001038 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 794851001039 PYR/PP interface [polypeptide binding]; other site 794851001040 dimer interface [polypeptide binding]; other site 794851001041 TPP binding site [chemical binding]; other site 794851001042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 794851001043 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 794851001044 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 794851001045 active site 794851001046 Riboflavin kinase; Region: Flavokinase; smart00904 794851001047 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 794851001048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 794851001049 RNA binding surface [nucleotide binding]; other site 794851001050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851001051 S-adenosylmethionine binding site [chemical binding]; other site 794851001052 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 794851001053 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 794851001054 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 794851001055 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851001056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 794851001057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 794851001058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851001059 Walker A/P-loop; other site 794851001060 ATP binding site [chemical binding]; other site 794851001061 Q-loop/lid; other site 794851001062 ABC transporter signature motif; other site 794851001063 Walker B; other site 794851001064 D-loop; other site 794851001065 H-loop/switch region; other site 794851001066 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 794851001067 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787 794851001068 Restriction endonuclease; Region: Mrr_cat; pfam04471 794851001069 Predicted ATPases [General function prediction only]; Region: COG1106 794851001070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851001071 Walker A/P-loop; other site 794851001072 ATP binding site [chemical binding]; other site 794851001073 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 794851001074 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 794851001075 active site 794851001076 Zn binding site [ion binding]; other site 794851001077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 794851001078 metal-binding site [ion binding] 794851001079 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 794851001080 metal-binding site [ion binding] 794851001081 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 794851001082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 794851001083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 794851001084 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 794851001085 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 794851001086 FtsH Extracellular; Region: FtsH_ext; pfam06480 794851001087 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 794851001088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851001089 Walker A motif; other site 794851001090 ATP binding site [chemical binding]; other site 794851001091 Walker B motif; other site 794851001092 arginine finger; other site 794851001093 Peptidase family M41; Region: Peptidase_M41; pfam01434 794851001094 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 794851001095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 794851001096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 794851001097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851001098 active site 794851001099 phosphorylation site [posttranslational modification] 794851001100 intermolecular recognition site; other site 794851001101 dimerization interface [polypeptide binding]; other site 794851001102 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001103 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 794851001104 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 794851001105 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 794851001106 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 794851001107 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 794851001108 sec-independent translocase; Provisional; Region: PRK04098 794851001109 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 794851001110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851001111 Walker A motif; other site 794851001112 ATP binding site [chemical binding]; other site 794851001113 Walker B motif; other site 794851001114 arginine finger; other site 794851001115 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 794851001116 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 794851001117 oligomerization interface [polypeptide binding]; other site 794851001118 active site 794851001119 metal binding site [ion binding]; metal-binding site 794851001120 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001121 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001122 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 794851001123 septum formation inhibitor; Reviewed; Region: minC; PRK00556 794851001124 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 794851001125 UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325 794851001126 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 794851001127 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 794851001128 homoserine kinase; Region: thrB; TIGR00191 794851001129 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 794851001130 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 794851001131 translation initiation factor IF-2; Region: IF-2; TIGR00487 794851001132 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 794851001133 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 794851001134 G1 box; other site 794851001135 putative GEF interaction site [polypeptide binding]; other site 794851001136 GTP/Mg2+ binding site [chemical binding]; other site 794851001137 Switch I region; other site 794851001138 G2 box; other site 794851001139 G3 box; other site 794851001140 Switch II region; other site 794851001141 G4 box; other site 794851001142 G5 box; other site 794851001143 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 794851001144 Translation-initiation factor 2; Region: IF-2; pfam11987 794851001145 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 794851001146 Ribosome-binding factor A; Region: RBFA; cl00542 794851001147 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 794851001148 Sm and related proteins; Region: Sm_like; cl00259 794851001149 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 794851001150 putative oligomer interface [polypeptide binding]; other site 794851001151 putative RNA binding site [nucleotide binding]; other site 794851001152 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 794851001153 putative active site [active] 794851001154 putative metal binding site [ion binding]; other site 794851001155 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 794851001156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 794851001157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851001158 active site 794851001159 intermolecular recognition site; other site 794851001160 dimerization interface [polypeptide binding]; other site 794851001161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 794851001162 DNA binding site [nucleotide binding] 794851001163 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 794851001164 flagellar biosynthesis protein FlhA; Region: FlhA; TIGR01398 794851001165 FHIPEP family; Region: FHIPEP; pfam00771 794851001166 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 794851001167 16S/18S rRNA binding site [nucleotide binding]; other site 794851001168 S13e-L30e interaction site [polypeptide binding]; other site 794851001169 25S rRNA binding site [nucleotide binding]; other site 794851001170 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 794851001171 O-Antigen ligase; Region: Wzy_C; pfam04932 794851001172 Dehydroquinase class II; Region: DHquinase_II; pfam01220 794851001173 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 794851001174 trimer interface [polypeptide binding]; other site 794851001175 active site 794851001176 dimer interface [polypeptide binding]; other site 794851001177 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 794851001178 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 794851001179 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 794851001180 active site 794851001181 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 794851001182 catalytic center binding site [active] 794851001183 ATP binding site [chemical binding]; other site 794851001184 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 794851001185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 794851001186 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 794851001187 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 794851001188 P-loop; other site 794851001189 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 794851001190 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 794851001191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 794851001192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 794851001193 DNA binding residues [nucleotide binding] 794851001194 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 794851001195 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 794851001196 flagellar motor switch protein FliY; Validated; Region: PRK08432 794851001197 flagellar motor switch protein FliN; Region: fliN; TIGR02480 794851001198 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 794851001199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 794851001200 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 794851001201 metal binding site 2 [ion binding]; metal-binding site 794851001202 putative DNA binding helix; other site 794851001203 metal binding site 1 [ion binding]; metal-binding site 794851001204 dimer interface [polypeptide binding]; other site 794851001205 structural Zn2+ binding site [ion binding]; other site 794851001206 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 794851001207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851001208 Walker A motif; other site 794851001209 ATP binding site [chemical binding]; other site 794851001210 Walker B motif; other site 794851001211 arginine finger; other site 794851001212 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 794851001213 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 794851001214 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 794851001215 DNA binding residues [nucleotide binding] 794851001216 putative dimer interface [polypeptide binding]; other site 794851001217 chaperone protein DnaJ; Provisional; Region: PRK14299 794851001218 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 794851001219 HSP70 interaction site [polypeptide binding]; other site 794851001220 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 794851001221 substrate binding site [polypeptide binding]; other site 794851001222 dimer interface [polypeptide binding]; other site 794851001223 5'-3' exonuclease; Provisional; Region: PRK14976 794851001224 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 794851001225 putative active site [active] 794851001226 Helix-hairpin-helix class 2 (Pol1 family) motifs; Region: HhH2; smart00279 794851001227 DNA binding site [nucleotide binding] 794851001228 metal binding site [ion binding]; metal-binding site 794851001229 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 794851001230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851001231 active site 794851001232 dimerization interface [polypeptide binding]; other site 794851001233 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 794851001234 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 794851001235 substrate binding site; other site 794851001236 dimer interface; other site 794851001237 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 794851001238 homotrimer interaction site [polypeptide binding]; other site 794851001239 zinc binding site [ion binding]; other site 794851001240 CDP-binding sites; other site 794851001241 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 794851001242 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 794851001243 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 794851001244 protein binding site [polypeptide binding]; other site 794851001245 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 794851001246 protein binding site [polypeptide binding]; other site 794851001247 S-methylmethionine transporter; Provisional; Region: PRK11387 794851001248 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 794851001249 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 794851001250 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 794851001251 putative NAD(P) binding site [chemical binding]; other site 794851001252 active site 794851001253 dihydrodipicolinate synthase; Region: dapA; TIGR00674 794851001254 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 794851001255 dimer interface [polypeptide binding]; other site 794851001256 active site 794851001257 catalytic residue [active] 794851001258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 794851001259 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 794851001260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 794851001261 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 794851001262 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 794851001263 quinone interaction residues [chemical binding]; other site 794851001264 active site 794851001265 catalytic residues [active] 794851001266 FMN binding site [chemical binding]; other site 794851001267 substrate binding site [chemical binding]; other site 794851001268 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 794851001269 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 794851001270 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 794851001271 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 794851001272 putative domain interface [polypeptide binding]; other site 794851001273 putative active site [active] 794851001274 catalytic site [active] 794851001275 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 794851001276 putative active site [active] 794851001277 putative domain interface [polypeptide binding]; other site 794851001278 catalytic site [active] 794851001279 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 794851001280 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001281 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001282 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 794851001283 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851001284 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 794851001285 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 794851001286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851001287 ATP binding site [chemical binding]; other site 794851001288 putative Mg++ binding site [ion binding]; other site 794851001289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 794851001290 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 794851001291 putative metal binding site [ion binding]; other site 794851001292 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 794851001293 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 794851001294 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 794851001295 active site 794851001296 Zn binding site [ion binding]; other site 794851001297 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 794851001298 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 794851001299 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001300 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 794851001301 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 794851001302 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 794851001303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851001304 dimer interface [polypeptide binding]; other site 794851001305 conserved gate region; other site 794851001306 putative PBP binding loops; other site 794851001307 ABC-ATPase subunit interface; other site 794851001308 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 794851001309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851001310 Walker A/P-loop; other site 794851001311 ATP binding site [chemical binding]; other site 794851001312 Q-loop/lid; other site 794851001313 ABC transporter signature motif; other site 794851001314 Walker B; other site 794851001315 D-loop; other site 794851001316 H-loop/switch region; other site 794851001317 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 794851001318 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 794851001319 active site 794851001320 HIGH motif; other site 794851001321 nucleotide binding site [chemical binding]; other site 794851001322 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 794851001323 active site 794851001324 KMSKS motif; other site 794851001325 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001326 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 794851001327 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851001328 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 794851001329 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 794851001330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 794851001331 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 794851001332 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 794851001333 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 794851001334 G1 box; other site 794851001335 putative GEF interaction site [polypeptide binding]; other site 794851001336 GTP/Mg2+ binding site [chemical binding]; other site 794851001337 Switch I region; other site 794851001338 G2 box; other site 794851001339 G3 box; other site 794851001340 Switch II region; other site 794851001341 G4 box; other site 794851001342 G5 box; other site 794851001343 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 794851001344 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 794851001345 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 794851001346 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 794851001347 GIY-YIG motif/motif A; other site 794851001348 DNA binding site [nucleotide binding] 794851001349 active site 794851001350 catalytic site [active] 794851001351 metal binding site [ion binding]; metal-binding site 794851001352 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 794851001353 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851001354 cofactor binding site; other site 794851001355 DNA binding site [nucleotide binding] 794851001356 substrate interaction site [chemical binding]; other site 794851001357 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851001358 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 794851001359 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 794851001360 putative heme binding pocket [chemical binding]; other site 794851001361 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851001362 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851001363 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 794851001364 Uncharacterized conserved protein [Function unknown]; Region: COG1432 794851001365 LabA_like proteins; Region: LabA_like; cd06167 794851001366 putative metal binding site [ion binding]; other site 794851001367 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 794851001368 active site 794851001369 putative DNA-binding cleft [nucleotide binding]; other site 794851001370 dimer interface [polypeptide binding]; other site 794851001371 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 794851001372 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 794851001373 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 794851001374 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 794851001375 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 794851001376 tetramer interface [polypeptide binding]; other site 794851001377 heme binding pocket [chemical binding]; other site 794851001378 NADPH binding site [chemical binding]; other site 794851001379 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 794851001380 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 794851001381 PhnA protein; Region: PhnA; pfam03831 794851001382 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 794851001383 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 794851001384 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 794851001385 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 794851001386 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 794851001387 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 794851001388 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 794851001389 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 794851001390 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 794851001391 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 794851001392 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 794851001393 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 794851001394 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 794851001395 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 794851001396 trimer interface [polypeptide binding]; other site 794851001397 active site 794851001398 PQQ-like domain; Region: PQQ_2; pfam13360 794851001399 pantothenate kinase; Reviewed; Region: PRK13333 794851001400 Uncharacterized conserved protein [Function unknown]; Region: COG2836 794851001401 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 794851001402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 794851001403 active site 794851001404 motif I; other site 794851001405 motif II; other site 794851001406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 794851001407 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 794851001408 NAD(P) binding site [chemical binding]; other site 794851001409 active site 794851001410 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 794851001411 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 794851001412 putative ribose interaction site [chemical binding]; other site 794851001413 putative ADP binding site [chemical binding]; other site 794851001414 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 794851001415 active site 794851001416 nucleotide binding site [chemical binding]; other site 794851001417 HIGH motif; other site 794851001418 KMSKS motif; other site 794851001419 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 794851001420 dimer interface [polypeptide binding]; other site 794851001421 active site 794851001422 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 794851001423 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 794851001424 active site 794851001425 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 794851001426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851001427 Walker A/P-loop; other site 794851001428 ATP binding site [chemical binding]; other site 794851001429 Q-loop/lid; other site 794851001430 ABC transporter signature motif; other site 794851001431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 794851001432 ABC transporter; Region: ABC_tran_2; pfam12848 794851001433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 794851001434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958 794851001435 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 794851001436 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 794851001437 active site 794851001438 HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556 794851001439 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851001440 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 794851001441 cofactor binding site; other site 794851001442 DNA binding site [nucleotide binding] 794851001443 substrate interaction site [chemical binding]; other site 794851001444 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 794851001445 HsdM N-terminal domain; Region: HsdM_N; pfam12161 794851001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851001447 S-adenosylmethionine binding site [chemical binding]; other site 794851001448 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001449 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 794851001450 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001451 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 794851001452 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 794851001453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851001454 ATP binding site [chemical binding]; other site 794851001455 putative Mg++ binding site [ion binding]; other site 794851001456 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 794851001457 substrate binding site [chemical binding]; other site 794851001458 multimerization interface [polypeptide binding]; other site 794851001459 ATP binding site [chemical binding]; other site 794851001460 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 794851001461 dimer interface [polypeptide binding]; other site 794851001462 substrate binding site [chemical binding]; other site 794851001463 ATP binding site [chemical binding]; other site 794851001464 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 794851001465 thiamine phosphate binding site [chemical binding]; other site 794851001466 active site 794851001467 pyrophosphate binding site [ion binding]; other site 794851001468 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 794851001469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851001470 ATP binding site [chemical binding]; other site 794851001471 putative Mg++ binding site [ion binding]; other site 794851001472 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 794851001473 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 794851001474 NeuB family; Region: NeuB; pfam03102 794851001475 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 794851001476 NeuB binding interface [polypeptide binding]; other site 794851001477 putative substrate binding site [chemical binding]; other site 794851001478 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 794851001479 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 794851001480 active site 794851001481 homodimer interface [polypeptide binding]; other site 794851001482 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 794851001483 ligand binding site; other site 794851001484 tetramer interface; other site 794851001485 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 794851001486 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 794851001487 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 794851001488 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 794851001489 Flavoprotein; Region: Flavoprotein; pfam02441 794851001490 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 794851001491 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 794851001492 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 794851001493 NAD(P) binding site [chemical binding]; other site 794851001494 homodimer interface [polypeptide binding]; other site 794851001495 substrate binding site [chemical binding]; other site 794851001496 active site 794851001497 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 794851001498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 794851001499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 794851001500 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 794851001501 IHF dimer interface [polypeptide binding]; other site 794851001502 IHF - DNA interface [nucleotide binding]; other site 794851001503 GTP-binding protein Der; Reviewed; Region: PRK00093 794851001504 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 794851001505 G1 box; other site 794851001506 GTP/Mg2+ binding site [chemical binding]; other site 794851001507 Switch I region; other site 794851001508 G2 box; other site 794851001509 Switch II region; other site 794851001510 G3 box; other site 794851001511 G4 box; other site 794851001512 G5 box; other site 794851001513 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 794851001514 G1 box; other site 794851001515 GTP/Mg2+ binding site [chemical binding]; other site 794851001516 Switch I region; other site 794851001517 G2 box; other site 794851001518 G3 box; other site 794851001519 Switch II region; other site 794851001520 G4 box; other site 794851001521 G5 box; other site 794851001522 spermidine synthase; Provisional; Region: speE; PRK00536 794851001523 spermidine synthase; Provisional; Region: PRK00811 794851001524 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 794851001525 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 794851001526 CoA-binding site [chemical binding]; other site 794851001527 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 794851001528 indole acetimide hydrolase; Validated; Region: PRK07488 794851001529 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 794851001530 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 794851001531 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 794851001532 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 794851001533 active site 794851001534 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 794851001535 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 794851001536 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 794851001537 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 794851001538 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 794851001539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 794851001540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 794851001541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 794851001542 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 794851001543 catalytic residues [active] 794851001544 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 794851001545 homoserine dehydrogenase; Provisional; Region: PRK06349 794851001546 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 794851001547 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 794851001548 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 794851001549 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 794851001550 GIY-YIG motif/motif A; other site 794851001551 active site 794851001552 catalytic site [active] 794851001553 putative DNA binding site [nucleotide binding]; other site 794851001554 metal binding site [ion binding]; metal-binding site 794851001555 UvrB/uvrC motif; Region: UVR; pfam02151 794851001556 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 794851001557 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 794851001558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851001559 Walker A/P-loop; other site 794851001560 ATP binding site [chemical binding]; other site 794851001561 Q-loop/lid; other site 794851001562 ABC transporter signature motif; other site 794851001563 Walker B; other site 794851001564 D-loop; other site 794851001565 H-loop/switch region; other site 794851001566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851001567 dimer interface [polypeptide binding]; other site 794851001568 conserved gate region; other site 794851001569 ABC-ATPase subunit interface; other site 794851001570 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 794851001571 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 794851001572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 794851001573 ligand binding site [chemical binding]; other site 794851001574 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 794851001575 flagellar motor protein MotA; Validated; Region: PRK08456 794851001576 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 794851001577 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 794851001578 ATP binding site [chemical binding]; other site 794851001579 substrate interface [chemical binding]; other site 794851001580 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 794851001581 Uncharacterized conserved protein [Function unknown]; Region: COG1565 794851001582 RNA methyltransferase, RsmD family; Region: TIGR00095 794851001583 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 794851001584 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 794851001585 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 794851001586 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 794851001587 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 794851001588 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 794851001589 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 794851001590 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: ribB; TIGR00506 794851001591 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 794851001592 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 794851001593 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 794851001594 dimerization interface [polypeptide binding]; other site 794851001595 active site 794851001596 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 794851001597 MoaE interaction surface [polypeptide binding]; other site 794851001598 MoeB interaction surface [polypeptide binding]; other site 794851001599 thiocarboxylated glycine; other site 794851001600 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 794851001601 MoaE homodimer interface [polypeptide binding]; other site 794851001602 MoaD interaction [polypeptide binding]; other site 794851001603 active site residues [active] 794851001604 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 794851001605 MPT binding site; other site 794851001606 trimer interface [polypeptide binding]; other site 794851001607 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 794851001608 trimer interface [polypeptide binding]; other site 794851001609 dimer interface [polypeptide binding]; other site 794851001610 putative active site [active] 794851001611 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 794851001612 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 794851001613 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 794851001614 DNA binding residues [nucleotide binding] 794851001615 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 794851001616 catalytic residues [active] 794851001617 catalytic nucleophile [active] 794851001618 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 794851001619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 794851001620 Probable transposase; Region: OrfB_IS605; pfam01385 794851001621 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 794851001622 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001623 trigger factor; Provisional; Region: tig; PRK01490 794851001624 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 794851001625 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 794851001626 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 794851001627 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 794851001628 oligomer interface [polypeptide binding]; other site 794851001629 active site residues [active] 794851001630 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 794851001631 active site 794851001632 catalytic residues [active] 794851001633 metal binding site [ion binding]; metal-binding site 794851001634 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 794851001635 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 794851001636 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 794851001637 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 794851001638 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 794851001639 metal-binding site [ion binding] 794851001640 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 794851001641 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 794851001642 Soluble P-type ATPase [General function prediction only]; Region: COG4087 794851001643 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001644 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 794851001645 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851001646 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851001647 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 794851001648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 794851001649 FtsX-like permease family; Region: FtsX; pfam02687 794851001650 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 794851001651 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 794851001652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851001653 nucleotide binding region [chemical binding]; other site 794851001654 ATP-binding site [chemical binding]; other site 794851001655 SEC-C motif; Region: SEC-C; pfam02810 794851001656 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 794851001657 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 794851001658 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851001659 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 794851001660 aconitate hydratase 2; Region: acnB; TIGR00117 794851001661 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 794851001662 substrate binding site [chemical binding]; other site 794851001663 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 794851001664 substrate binding site [chemical binding]; other site 794851001665 ligand binding site [chemical binding]; other site 794851001666 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 794851001667 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 794851001668 putative nucleotide binding site [chemical binding]; other site 794851001669 uridine monophosphate binding site [chemical binding]; other site 794851001670 homohexameric interface [polypeptide binding]; other site 794851001671 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 794851001672 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 794851001673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 794851001674 Zn2+ binding site [ion binding]; other site 794851001675 Mg2+ binding site [ion binding]; other site 794851001676 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 794851001677 synthetase active site [active] 794851001678 NTP binding site [chemical binding]; other site 794851001679 metal binding site [ion binding]; metal-binding site 794851001680 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 794851001681 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 794851001682 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 794851001683 active site 794851001684 HIGH motif; other site 794851001685 dimer interface [polypeptide binding]; other site 794851001686 KMSKS motif; other site 794851001687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 794851001688 RNA binding surface [nucleotide binding]; other site 794851001689 Nitronate monooxygenase; Region: NMO; pfam03060 794851001690 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 794851001691 FMN binding site [chemical binding]; other site 794851001692 substrate binding site [chemical binding]; other site 794851001693 putative catalytic residue [active] 794851001694 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 794851001695 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 794851001696 active site 794851001697 metal binding site [ion binding]; metal-binding site 794851001698 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 794851001699 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 794851001700 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 794851001701 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 794851001702 GTP binding site; other site 794851001703 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 794851001704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851001705 FeS/SAM binding site; other site 794851001706 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 794851001707 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 794851001708 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 794851001709 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 794851001710 P loop; other site 794851001711 GTP binding site [chemical binding]; other site 794851001712 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 794851001713 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 794851001714 phosphodiesterase; Provisional; Region: PRK12704 794851001715 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 794851001716 nucleic acid binding region [nucleotide binding]; other site 794851001717 G-X-X-G motif; other site 794851001718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 794851001719 Zn2+ binding site [ion binding]; other site 794851001720 Mg2+ binding site [ion binding]; other site 794851001721 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 794851001722 putative efflux protein, MATE family; Region: matE; TIGR00797 794851001723 Predicted permease [General function prediction only]; Region: COG2056 794851001724 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 794851001725 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 794851001726 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 794851001727 putative active site; other site 794851001728 catalytic triad [active] 794851001729 putative dimer interface [polypeptide binding]; other site 794851001730 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 794851001731 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 794851001732 putative ATP binding site [chemical binding]; other site 794851001733 putative substrate interface [chemical binding]; other site 794851001734 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 794851001735 flagellar capping protein; Validated; Region: fliD; PRK08453 794851001736 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 794851001737 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 794851001738 flagellar protein FlaG; Provisional; Region: PRK08452 794851001739 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 794851001740 Peptidase family M23; Region: Peptidase_M23; pfam01551 794851001741 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 794851001742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 794851001743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 794851001744 Walker A/P-loop; other site 794851001745 ATP binding site [chemical binding]; other site 794851001746 Q-loop/lid; other site 794851001747 ABC transporter signature motif; other site 794851001748 Walker B; other site 794851001749 D-loop; other site 794851001750 H-loop/switch region; other site 794851001751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851001752 S-adenosylmethionine binding site [chemical binding]; other site 794851001753 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 794851001754 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 794851001755 Interdomain contacts; other site 794851001756 Cytokine receptor motif; other site 794851001757 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 794851001758 Interdomain contacts; other site 794851001759 Cytokine receptor motif; other site 794851001760 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 794851001761 Interdomain contacts; other site 794851001762 Cytokine receptor motif; other site 794851001763 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 794851001764 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 794851001765 active site 794851001766 Predicted GTPase [General function prediction only]; Region: COG3596 794851001767 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 794851001768 G1 box; other site 794851001769 GTP/Mg2+ binding site [chemical binding]; other site 794851001770 G2 box; other site 794851001771 Switch I region; other site 794851001772 G3 box; other site 794851001773 Switch II region; other site 794851001774 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 794851001775 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 794851001776 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 794851001777 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 794851001778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 794851001779 active site 794851001780 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 794851001781 nucleotide binding site/active site [active] 794851001782 HIT family signature motif; other site 794851001783 catalytic residue [active] 794851001784 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 794851001785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 794851001786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 794851001787 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 794851001788 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 794851001789 ATP-grasp domain; Region: ATP-grasp_4; cl17255 794851001790 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 794851001791 tetramer interfaces [polypeptide binding]; other site 794851001792 binuclear metal-binding site [ion binding]; other site 794851001793 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 794851001794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 794851001795 catalytic residue [active] 794851001796 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 794851001797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 794851001798 active site 794851001799 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 794851001800 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 794851001801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851001802 FeS/SAM binding site; other site 794851001803 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 794851001804 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 794851001805 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 794851001806 Ligand Binding Site [chemical binding]; other site 794851001807 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 794851001808 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 794851001809 FMN binding site [chemical binding]; other site 794851001810 active site 794851001811 catalytic residues [active] 794851001812 substrate binding site [chemical binding]; other site 794851001813 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001814 anaerobic c4-dicarboxylate membrane transporter family protein; Region: Dcu; TIGR00770 794851001815 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 794851001816 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 794851001817 active site 794851001818 homotetramer interface [polypeptide binding]; other site 794851001819 homodimer interface [polypeptide binding]; other site 794851001820 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 794851001821 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 794851001822 Lysine efflux permease [General function prediction only]; Region: COG1279 794851001823 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 794851001824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851001825 Walker A motif; other site 794851001826 ATP binding site [chemical binding]; other site 794851001827 Walker B motif; other site 794851001828 arginine finger; other site 794851001829 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 794851001830 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 794851001831 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 794851001832 Walker A/P-loop; other site 794851001833 ATP binding site [chemical binding]; other site 794851001834 Q-loop/lid; other site 794851001835 ABC transporter signature motif; other site 794851001836 Walker B; other site 794851001837 D-loop; other site 794851001838 H-loop/switch region; other site 794851001839 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 794851001840 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 794851001841 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 794851001842 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 794851001843 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001844 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 794851001845 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 794851001846 Uncharacterized conserved protein [Function unknown]; Region: COG1912 794851001847 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 794851001848 MraW methylase family; Region: Methyltransf_5; cl17771 794851001849 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001850 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 794851001851 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 794851001852 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 794851001853 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 794851001854 Response regulator receiver domain; Region: Response_reg; pfam00072 794851001855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851001856 active site 794851001857 phosphorylation site [posttranslational modification] 794851001858 intermolecular recognition site; other site 794851001859 dimerization interface [polypeptide binding]; other site 794851001860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851001861 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 794851001862 Walker A motif; other site 794851001863 ATP binding site [chemical binding]; other site 794851001864 Walker B motif; other site 794851001865 arginine finger; other site 794851001866 DNA gyrase subunit A; Validated; Region: PRK05560 794851001867 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 794851001868 CAP-like domain; other site 794851001869 active site 794851001870 primary dimer interface [polypeptide binding]; other site 794851001871 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 794851001872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 794851001873 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 794851001874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 794851001875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 794851001876 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 794851001877 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 794851001878 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 794851001879 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 794851001880 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 794851001881 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 794851001882 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 794851001883 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 794851001884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 794851001885 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 794851001886 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 794851001887 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 794851001888 putative acyltransferase; Provisional; Region: PRK05790 794851001889 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 794851001890 dimer interface [polypeptide binding]; other site 794851001891 active site 794851001892 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 794851001893 active site 794851001894 catalytic site [active] 794851001895 substrate binding site [chemical binding]; other site 794851001896 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 794851001897 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 794851001898 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 794851001899 G1 box; other site 794851001900 GTP/Mg2+ binding site [chemical binding]; other site 794851001901 Switch I region; other site 794851001902 G2 box; other site 794851001903 G3 box; other site 794851001904 Switch II region; other site 794851001905 G4 box; other site 794851001906 G5 box; other site 794851001907 Nucleoside recognition; Region: Gate; pfam07670 794851001908 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 794851001909 Nucleoside recognition; Region: Gate; pfam07670 794851001910 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 794851001911 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 794851001912 N-terminal plug; other site 794851001913 ligand-binding site [chemical binding]; other site 794851001914 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 794851001915 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 794851001916 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 794851001917 Substrate binding site; other site 794851001918 Mg++ binding site; other site 794851001919 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 794851001920 active site 794851001921 substrate binding site [chemical binding]; other site 794851001922 CoA binding site [chemical binding]; other site 794851001923 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 794851001924 ATP cone domain; Region: ATP-cone; pfam03477 794851001925 Class I ribonucleotide reductase; Region: RNR_I; cd01679 794851001926 active site 794851001927 dimer interface [polypeptide binding]; other site 794851001928 catalytic residues [active] 794851001929 effector binding site; other site 794851001930 R2 peptide binding site; other site 794851001931 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 794851001932 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 794851001933 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 794851001934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 794851001935 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 794851001936 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 794851001937 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 794851001938 DNA binding site [nucleotide binding] 794851001939 active site 794851001940 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 794851001941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 794851001942 active site 794851001943 DNA binding site [nucleotide binding] 794851001944 Int/Topo IB signature motif; other site 794851001945 aspartate aminotransferase; Provisional; Region: PRK05764 794851001946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 794851001947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851001948 homodimer interface [polypeptide binding]; other site 794851001949 catalytic residue [active] 794851001950 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851001951 Predicted helicase [General function prediction only]; Region: COG4889 794851001952 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 794851001953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851001954 ATP binding site [chemical binding]; other site 794851001955 putative Mg++ binding site [ion binding]; other site 794851001956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851001957 nucleotide binding region [chemical binding]; other site 794851001958 ATP-binding site [chemical binding]; other site 794851001959 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 794851001960 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 794851001961 Cysteine-rich domain; Region: CCG; pfam02754 794851001962 Cysteine-rich domain; Region: CCG; pfam02754 794851001963 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 794851001964 HemN C-terminal domain; Region: HemN_C; pfam06969 794851001965 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 794851001966 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 794851001967 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 794851001968 Tetramer interface [polypeptide binding]; other site 794851001969 active site 794851001970 FMN-binding site [chemical binding]; other site 794851001971 ribonuclease III; Reviewed; Region: rnc; PRK00102 794851001972 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 794851001973 dimerization interface [polypeptide binding]; other site 794851001974 active site 794851001975 metal binding site [ion binding]; metal-binding site 794851001976 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 794851001977 dsRNA binding site [nucleotide binding]; other site 794851001978 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 794851001979 RNA/DNA hybrid binding site [nucleotide binding]; other site 794851001980 active site 794851001981 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 794851001982 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 794851001983 SurA N-terminal domain; Region: SurA_N; pfam09312 794851001984 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 794851001985 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 794851001986 GatB domain; Region: GatB_Yqey; smart00845 794851001987 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 794851001988 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 794851001989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 794851001990 hypothetical protein; Provisional; Region: PRK08445 794851001991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851001992 FeS/SAM binding site; other site 794851001993 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 794851001994 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 794851001995 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 794851001996 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 794851001997 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 794851001998 Surface antigen; Region: Bac_surface_Ag; pfam01103 794851001999 hypothetical protein; Provisional; Region: PRK08444 794851002000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851002001 FeS/SAM binding site; other site 794851002002 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 794851002003 Ferritin-like domain; Region: Ferritin; pfam00210 794851002004 ferroxidase diiron center [ion binding]; other site 794851002005 phosphoserine phosphatase SerB; Region: serB; TIGR00338 794851002006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 794851002007 motif II; other site 794851002008 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 794851002009 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 794851002010 ligand binding site [chemical binding]; other site 794851002011 active site 794851002012 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 794851002013 Aspartase; Region: Aspartase; cd01357 794851002014 active sites [active] 794851002015 tetramer interface [polypeptide binding]; other site 794851002016 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 794851002017 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 794851002018 hinge; other site 794851002019 active site 794851002020 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 794851002021 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 794851002022 active site 794851002023 tetramer interface; other site 794851002024 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 794851002025 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 794851002026 N-acetyl-D-glucosamine binding site [chemical binding]; other site 794851002027 catalytic residue [active] 794851002028 YGGT family; Region: YGGT; pfam02325 794851002029 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 794851002030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 794851002031 active site 794851002032 HIGH motif; other site 794851002033 nucleotide binding site [chemical binding]; other site 794851002034 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 794851002035 active site 794851002036 KMSKS motif; other site 794851002037 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 794851002038 dimer interface [polypeptide binding]; other site 794851002039 FMN binding site [chemical binding]; other site 794851002040 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 794851002041 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 794851002042 active site 794851002043 NTP binding site [chemical binding]; other site 794851002044 metal binding triad [ion binding]; metal-binding site 794851002045 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 794851002046 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 794851002047 Ligand Binding Site [chemical binding]; other site 794851002048 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002049 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 794851002050 nickel binding site [ion binding]; other site 794851002051 putative substrate-binding site; other site 794851002052 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 794851002053 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 794851002054 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 794851002055 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 794851002056 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 794851002057 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 794851002058 Uncharacterized conserved protein [Function unknown]; Region: COG1479 794851002059 Protein of unknown function DUF262; Region: DUF262; pfam03235 794851002060 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 794851002061 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851002062 Sel1-like repeats; Region: SEL1; smart00671 794851002063 Sel1-like repeats; Region: SEL1; smart00671 794851002064 Sel1 repeat; Region: Sel1; cl02723 794851002065 Sel1-like repeats; Region: SEL1; smart00671 794851002066 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 794851002067 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 794851002068 putative trimer interface [polypeptide binding]; other site 794851002069 putative CoA binding site [chemical binding]; other site 794851002070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 794851002071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 794851002072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 794851002073 hypothetical protein; Provisional; Region: PRK05839 794851002074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 794851002075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851002076 homodimer interface [polypeptide binding]; other site 794851002077 catalytic residue [active] 794851002078 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 794851002079 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 794851002080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 794851002081 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 794851002082 MutS2 family protein; Region: mutS2; TIGR01069 794851002083 ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534 794851002084 Walker A/P-loop; other site 794851002085 ATP binding site [chemical binding]; other site 794851002086 Q-loop/lid; other site 794851002087 ABC transporter signature motif; other site 794851002088 Walker B; other site 794851002089 D-loop; other site 794851002090 H-loop/switch region; other site 794851002091 Smr domain; Region: Smr; pfam01713 794851002092 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 794851002093 dimer interface [polypeptide binding]; other site 794851002094 substrate binding site [chemical binding]; other site 794851002095 metal binding sites [ion binding]; metal-binding site 794851002096 Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306 794851002097 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 794851002098 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 794851002099 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 794851002100 adenylate kinase; Reviewed; Region: adk; PRK00279 794851002101 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 794851002102 AMP-binding site [chemical binding]; other site 794851002103 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 794851002104 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 794851002105 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 794851002106 dimer interface [polypeptide binding]; other site 794851002107 anticodon binding site; other site 794851002108 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 794851002109 homodimer interface [polypeptide binding]; other site 794851002110 motif 1; other site 794851002111 active site 794851002112 motif 2; other site 794851002113 GAD domain; Region: GAD; pfam02938 794851002114 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 794851002115 active site 794851002116 motif 3; other site 794851002117 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 794851002118 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 794851002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851002120 active site 794851002121 phosphorylation site [posttranslational modification] 794851002122 intermolecular recognition site; other site 794851002123 dimerization interface [polypeptide binding]; other site 794851002124 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 794851002125 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 794851002126 nucleotide binding pocket [chemical binding]; other site 794851002127 K-X-D-G motif; other site 794851002128 catalytic site [active] 794851002129 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 794851002130 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 794851002131 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 794851002132 Dimer interface [polypeptide binding]; other site 794851002133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851002134 Walker B; other site 794851002135 D-loop; other site 794851002136 H-loop/switch region; other site 794851002137 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 794851002138 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002139 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002140 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002141 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002142 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 794851002143 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002144 Autotransporter beta-domain; Region: Autotransporter; pfam03797 794851002145 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002146 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 794851002147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 794851002148 HlyD family secretion protein; Region: HlyD_3; pfam13437 794851002149 Outer membrane efflux protein; Region: OEP; pfam02321 794851002150 Outer membrane efflux protein; Region: OEP; pfam02321 794851002151 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 794851002152 substrate binding site [chemical binding]; other site 794851002153 active site 794851002154 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 794851002155 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 794851002156 minor groove reading motif; other site 794851002157 helix-hairpin-helix signature motif; other site 794851002158 active site 794851002159 flagellin A; Reviewed; Region: PRK12584 794851002160 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 794851002161 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 794851002162 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 794851002163 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 794851002164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851002165 ABC transporter; Region: ABC_tran; pfam00005 794851002166 Q-loop/lid; other site 794851002167 ABC transporter signature motif; other site 794851002168 Walker B; other site 794851002169 D-loop; other site 794851002170 H-loop/switch region; other site 794851002171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 794851002172 dimer interface [polypeptide binding]; other site 794851002173 putative CheW interface [polypeptide binding]; other site 794851002174 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 794851002175 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 794851002176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 794851002177 catalytic residue [active] 794851002178 Transglycosylase; Region: Transgly; pfam00912 794851002179 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 794851002180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 794851002181 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 794851002182 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 794851002183 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 794851002184 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 794851002185 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 794851002186 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 794851002187 TPP-binding site [chemical binding]; other site 794851002188 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 794851002189 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 794851002190 dimer interface [polypeptide binding]; other site 794851002191 PYR/PP interface [polypeptide binding]; other site 794851002192 TPP binding site [chemical binding]; other site 794851002193 substrate binding site [chemical binding]; other site 794851002194 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 794851002195 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 794851002196 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 794851002197 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 794851002198 dimerization interface [polypeptide binding]; other site 794851002199 Protein of unknown function; Region: DUF3971; pfam13116 794851002200 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 794851002201 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 794851002202 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 794851002203 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 794851002204 minor groove reading motif; other site 794851002205 helix-hairpin-helix signature motif; other site 794851002206 substrate binding pocket [chemical binding]; other site 794851002207 active site 794851002208 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 794851002209 flagellar motor switch protein; Validated; Region: PRK08433 794851002210 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 794851002211 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 794851002212 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 794851002213 active site 794851002214 substrate binding pocket [chemical binding]; other site 794851002215 dimer interface [polypeptide binding]; other site 794851002216 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 794851002217 BNR repeat-like domain; Region: BNR_2; pfam13088 794851002218 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 794851002219 Sulfatase; Region: Sulfatase; pfam00884 794851002220 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 794851002221 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 794851002222 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 794851002223 homodimer interface [polypeptide binding]; other site 794851002224 NADP binding site [chemical binding]; other site 794851002225 substrate binding site [chemical binding]; other site 794851002226 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 794851002227 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 794851002228 Catalytic site [active] 794851002229 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 794851002230 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 794851002231 Peptidase family M50; Region: Peptidase_M50; pfam02163 794851002232 active site 794851002233 putative substrate binding region [chemical binding]; other site 794851002234 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 794851002235 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 794851002236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 794851002237 active site 794851002238 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 794851002239 multifunctional aminopeptidase A; Provisional; Region: PRK00913 794851002240 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 794851002241 interface (dimer of trimers) [polypeptide binding]; other site 794851002242 Substrate-binding/catalytic site; other site 794851002243 Zn-binding sites [ion binding]; other site 794851002244 GTP-binding protein YchF; Reviewed; Region: PRK09601 794851002245 YchF GTPase; Region: YchF; cd01900 794851002246 G1 box; other site 794851002247 GTP/Mg2+ binding site [chemical binding]; other site 794851002248 Switch I region; other site 794851002249 G2 box; other site 794851002250 Switch II region; other site 794851002251 G3 box; other site 794851002252 G4 box; other site 794851002253 G5 box; other site 794851002254 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 794851002255 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 794851002256 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 794851002257 Domain of unknown function DUF20; Region: UPF0118; pfam01594 794851002258 diaminopimelate epimerase; Region: DapF; TIGR00652 794851002259 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 794851002260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 794851002261 Predicted membrane protein [Function unknown]; Region: COG3059 794851002262 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 794851002263 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 794851002264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 794851002265 NAD(P) binding site [chemical binding]; other site 794851002266 active site 794851002267 acyl carrier protein; Provisional; Region: acpP; PRK00982 794851002268 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 794851002269 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 794851002270 dimer interface [polypeptide binding]; other site 794851002271 active site 794851002272 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Region: accA; TIGR00513 794851002273 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 794851002274 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 794851002275 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 794851002276 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 794851002277 Predicted methyltransferases [General function prediction only]; Region: COG0313 794851002278 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 794851002279 putative SAM binding site [chemical binding]; other site 794851002280 putative homodimer interface [polypeptide binding]; other site 794851002281 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 794851002282 transcription termination factor Rho; Provisional; Region: rho; PRK09376 794851002283 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 794851002284 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 794851002285 RNA binding site [nucleotide binding]; other site 794851002286 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 794851002287 multimer interface [polypeptide binding]; other site 794851002288 Walker A motif; other site 794851002289 ATP binding site [chemical binding]; other site 794851002290 Walker B motif; other site 794851002291 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 794851002292 CagA exotoxin; Region: CagA; pfam03507 794851002293 CagA exotoxin; Region: CagA; pfam03507 794851002294 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 794851002295 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 794851002296 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 794851002297 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 794851002298 VirB7 interaction site; other site 794851002299 DC-EC Repeat; Region: CagY_M; pfam07337 794851002300 DC-EC Repeat; Region: CagY_M; pfam07337 794851002301 DC-EC Repeat; Region: CagY_M; pfam07337 794851002302 DC-EC Repeat; Region: CagY_M; pfam07337 794851002303 DC-EC Repeat; Region: CagY_M; pfam07337 794851002304 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 794851002305 CagZ; Region: CagZ; pfam09053 794851002306 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 794851002307 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 794851002308 ATP binding site [chemical binding]; other site 794851002309 Walker A motif; other site 794851002310 hexamer interface [polypeptide binding]; other site 794851002311 Walker B motif; other site 794851002312 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 794851002313 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 794851002314 Walker A motif; other site 794851002315 ATP binding site [chemical binding]; other site 794851002316 Walker B motif; other site 794851002317 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851002318 Sel1-like repeats; Region: SEL1; smart00671 794851002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 794851002320 GTPase [General function prediction only]; Region: Era; COG1159 794851002321 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 794851002322 G1 box; other site 794851002323 GTP/Mg2+ binding site [chemical binding]; other site 794851002324 Switch I region; other site 794851002325 G2 box; other site 794851002326 Switch II region; other site 794851002327 G3 box; other site 794851002328 G4 box; other site 794851002329 G5 box; other site 794851002330 KH domain; Region: KH_2; pfam07650 794851002331 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 794851002332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851002333 Walker A motif; other site 794851002334 ATP binding site [chemical binding]; other site 794851002335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851002336 Walker B motif; other site 794851002337 arginine finger; other site 794851002338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 794851002339 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 794851002340 active site 794851002341 HslU subunit interaction site [polypeptide binding]; other site 794851002342 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 794851002343 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 794851002344 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 794851002345 Uncharacterized conserved protein [Function unknown]; Region: COG1479 794851002346 Protein of unknown function DUF262; Region: DUF262; pfam03235 794851002347 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 794851002348 Uncharacterized conserved protein [Function unknown]; Region: COG3586 794851002349 glutamine synthetase, type I; Region: GlnA; TIGR00653 794851002350 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 794851002351 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 794851002352 dihydrodipicolinate reductase; Region: dapB; TIGR00036 794851002353 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 794851002354 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 794851002355 FAD binding domain; Region: FAD_binding_4; pfam01565 794851002356 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 794851002357 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 794851002358 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 794851002359 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 794851002360 dimer interface [polypeptide binding]; other site 794851002361 ADP-ribose binding site [chemical binding]; other site 794851002362 active site 794851002363 nudix motif; other site 794851002364 metal binding site [ion binding]; metal-binding site 794851002365 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 794851002366 Peptidase family M23; Region: Peptidase_M23; pfam01551 794851002367 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 794851002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851002369 Mg2+ binding site [ion binding]; other site 794851002370 G-X-G motif; other site 794851002371 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 794851002372 anchoring element; other site 794851002373 dimer interface [polypeptide binding]; other site 794851002374 ATP binding site [chemical binding]; other site 794851002375 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 794851002376 active site 794851002377 putative metal-binding site [ion binding]; other site 794851002378 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 794851002379 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 794851002380 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 794851002381 putative DNA binding surface [nucleotide binding]; other site 794851002382 dimer interface [polypeptide binding]; other site 794851002383 beta-clamp/translesion DNA polymerase binding surface; other site 794851002384 beta-clamp/clamp loader binding surface; other site 794851002385 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 794851002386 dimerization interface [polypeptide binding]; other site 794851002387 substrate binding site [chemical binding]; other site 794851002388 active site 794851002389 calcium binding site [ion binding]; other site 794851002390 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 794851002391 Na2 binding site [ion binding]; other site 794851002392 putative substrate binding site 1 [chemical binding]; other site 794851002393 Na binding site 1 [ion binding]; other site 794851002394 putative substrate binding site 2 [chemical binding]; other site 794851002395 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 794851002396 Na2 binding site [ion binding]; other site 794851002397 putative substrate binding site 1 [chemical binding]; other site 794851002398 Na binding site 1 [ion binding]; other site 794851002399 putative substrate binding site 2 [chemical binding]; other site 794851002400 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 794851002401 active site 794851002402 Protein of unknown function (DUF493); Region: DUF493; pfam04359 794851002403 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 794851002404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 794851002405 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 794851002406 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 794851002407 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 794851002408 Mg++ binding site [ion binding]; other site 794851002409 putative catalytic motif [active] 794851002410 putative substrate binding site [chemical binding]; other site 794851002411 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 794851002412 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 794851002413 Cation transport protein; Region: TrkH; cl17365 794851002414 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 794851002415 TrkA-N domain; Region: TrkA_N; pfam02254 794851002416 TrkA-C domain; Region: TrkA_C; pfam02080 794851002417 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 794851002418 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 794851002419 RuvA N terminal domain; Region: RuvA_N; pfam01330 794851002420 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 794851002421 Protein of unknown function (DUF342); Region: DUF342; pfam03961 794851002422 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 794851002423 MviN-like protein; Region: MVIN; pfam03023 794851002424 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 794851002425 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 794851002426 active site 794851002427 HIGH motif; other site 794851002428 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 794851002429 KMSKS motif; other site 794851002430 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 794851002431 tRNA binding surface [nucleotide binding]; other site 794851002432 anticodon binding site; other site 794851002433 Vacuolating cyotoxin; Region: VacA; pfam02691 794851002434 Autotransporter beta-domain; Region: Autotransporter; pfam03797 794851002435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 794851002436 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 794851002437 Probable transposase; Region: OrfB_IS605; pfam01385 794851002438 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 794851002439 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 794851002440 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 794851002441 Walker A/P-loop; other site 794851002442 ATP binding site [chemical binding]; other site 794851002443 Q-loop/lid; other site 794851002444 ABC transporter signature motif; other site 794851002445 Walker B; other site 794851002446 D-loop; other site 794851002447 H-loop/switch region; other site 794851002448 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 794851002449 ABC-ATPase subunit interface; other site 794851002450 dimer interface [polypeptide binding]; other site 794851002451 putative PBP binding regions; other site 794851002452 short chain dehydrogenase; Validated; Region: PRK06182 794851002453 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 794851002454 NADP binding site [chemical binding]; other site 794851002455 active site 794851002456 steroid binding site; other site 794851002457 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 794851002458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 794851002459 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002460 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 794851002461 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 794851002462 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 794851002463 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 794851002464 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 794851002465 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 794851002466 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 794851002467 propionate/acetate kinase; Provisional; Region: PRK12379 794851002468 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 794851002469 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 794851002470 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 794851002471 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 794851002472 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 794851002473 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 794851002474 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 794851002475 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 794851002476 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 794851002477 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851002478 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 794851002479 Part of AAA domain; Region: AAA_19; pfam13245 794851002480 Family description; Region: UvrD_C_2; pfam13538 794851002481 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002482 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002483 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851002484 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 794851002485 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 794851002486 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 794851002487 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 794851002488 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 794851002489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 794851002490 ATP-grasp domain; Region: ATP-grasp_4; cl17255 794851002491 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 794851002492 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 794851002493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 794851002494 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 794851002495 IMP binding site; other site 794851002496 dimer interface [polypeptide binding]; other site 794851002497 interdomain contacts; other site 794851002498 partial ornithine binding site; other site 794851002499 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 794851002500 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 794851002501 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 794851002502 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 794851002503 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 794851002504 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 794851002505 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002506 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 794851002507 Putative vacuolating cytotoxin; Region: VacA2; pfam03077 794851002508 Autotransporter beta-domain; Region: Autotransporter; pfam03797 794851002509 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002510 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 794851002511 active site 1 [active] 794851002512 dimer interface [polypeptide binding]; other site 794851002513 hexamer interface [polypeptide binding]; other site 794851002514 active site 2 [active] 794851002515 recombination protein RecR; Region: recR; TIGR00615 794851002516 RecR protein; Region: RecR; pfam02132 794851002517 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 794851002518 putative active site [active] 794851002519 putative metal-binding site [ion binding]; other site 794851002520 tetramer interface [polypeptide binding]; other site 794851002521 tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094 794851002522 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 794851002523 Permutation of conserved domain; other site 794851002524 active site 794851002525 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 794851002526 heat shock protein HtpX; Provisional; Region: PRK02870 794851002527 GTP cyclohydrolase I; Region: folE; TIGR00063 794851002528 GTP cyclohydrolase I; Provisional; Region: PLN03044 794851002529 active site 794851002530 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 794851002531 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 794851002532 substrate binding pocket [chemical binding]; other site 794851002533 chain length determination region; other site 794851002534 substrate-Mg2+ binding site; other site 794851002535 catalytic residues [active] 794851002536 aspartate-rich region 1; other site 794851002537 active site lid residues [active] 794851002538 aspartate-rich region 2; other site 794851002539 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 794851002540 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 794851002541 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 794851002542 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 794851002543 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 794851002544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 794851002545 Coenzyme A binding pocket [chemical binding]; other site 794851002546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 794851002547 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851002549 putative substrate translocation pore; other site 794851002550 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 794851002551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851002552 dimer interface [polypeptide binding]; other site 794851002553 conserved gate region; other site 794851002554 putative PBP binding loops; other site 794851002555 ABC-ATPase subunit interface; other site 794851002556 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 794851002557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 794851002558 substrate binding pocket [chemical binding]; other site 794851002559 membrane-bound complex binding site; other site 794851002560 hinge residues; other site 794851002561 alanine racemase; Region: alr; TIGR00492 794851002562 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 794851002563 active site 794851002564 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 794851002565 dimer interface [polypeptide binding]; other site 794851002566 substrate binding site [chemical binding]; other site 794851002567 catalytic residues [active] 794851002568 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 794851002569 amino acid carrier protein; Region: agcS; TIGR00835 794851002570 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 794851002571 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 794851002572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 794851002573 homotrimer interaction site [polypeptide binding]; other site 794851002574 putative active site [active] 794851002575 TRL-like protein family; Region: TRL; pfam13146 794851002576 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 794851002577 Uncharacterized conserved protein [Function unknown]; Region: COG1576 794851002578 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 794851002579 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 794851002580 putative recombination protein RecO; Provisional; Region: PRK13908 794851002581 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 794851002582 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 794851002583 dimer interface [polypeptide binding]; other site 794851002584 FMN binding site [chemical binding]; other site 794851002585 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 794851002586 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 794851002587 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 794851002588 active site 794851002589 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 794851002590 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 794851002591 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 794851002592 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 794851002593 Putative zinc ribbon domain; Region: DUF164; pfam02591 794851002594 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 794851002595 Uncharacterized conserved protein [Function unknown]; Region: COG0327 794851002596 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 794851002597 dimer interface [polypeptide binding]; other site 794851002598 motif 1; other site 794851002599 active site 794851002600 motif 2; other site 794851002601 motif 3; other site 794851002602 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 794851002603 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 794851002604 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 794851002605 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 794851002606 Dynamin family; Region: Dynamin_N; pfam00350 794851002607 G1 box; other site 794851002608 GTP/Mg2+ binding site [chemical binding]; other site 794851002609 G2 box; other site 794851002610 Switch I region; other site 794851002611 G3 box; other site 794851002612 Switch II region; other site 794851002613 G4 box; other site 794851002614 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 794851002615 G1 box; other site 794851002616 GTP/Mg2+ binding site [chemical binding]; other site 794851002617 G2 box; other site 794851002618 Switch I region; other site 794851002619 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 794851002620 G3 box; other site 794851002621 Switch II region; other site 794851002622 G4 box; other site 794851002623 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 794851002624 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 794851002625 potential frameshift: common BLAST hit: gi|188527788|ref|YP_001910475.1| putative cation efflux system protein 794851002626 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 794851002627 Outer membrane efflux protein; Region: OEP; pfam02321 794851002628 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 794851002629 phosphoglyceromutase; Provisional; Region: PRK05434 794851002630 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 794851002631 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 794851002632 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 794851002633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 794851002634 inhibitor-cofactor binding pocket; inhibition site 794851002635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851002636 catalytic residue [active] 794851002637 SurA N-terminal domain; Region: SurA_N_3; cl07813 794851002638 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 794851002639 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 794851002640 cell division protein FtsA; Region: ftsA; TIGR01174 794851002641 Cell division protein FtsA; Region: FtsA; smart00842 794851002642 Cell division protein FtsA; Region: FtsA; pfam14450 794851002643 cell division protein FtsZ; Validated; Region: PRK09330 794851002644 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 794851002645 nucleotide binding site [chemical binding]; other site 794851002646 SulA interaction site; other site 794851002647 potential frameshift: common BLAST hit: gi|15611893|ref|NP_223544.1| IS606 transposase 794851002648 Mechanosensitive ion channel; Region: MS_channel; pfam00924 794851002649 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 794851002650 generic binding surface II; other site 794851002651 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 794851002652 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 794851002653 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 794851002654 metal ion-dependent adhesion site (MIDAS); other site 794851002655 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 794851002656 DHH family; Region: DHH; pfam01368 794851002657 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 794851002658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 794851002659 active site 794851002660 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 794851002661 catalytic residues [active] 794851002662 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 794851002663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 794851002664 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 794851002665 putative ADP-binding pocket [chemical binding]; other site 794851002666 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 794851002667 active site 2 [active] 794851002668 active site 1 [active] 794851002669 Methyltransferase domain; Region: Methyltransf_23; pfam13489 794851002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851002671 S-adenosylmethionine binding site [chemical binding]; other site 794851002672 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 794851002673 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 794851002674 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 794851002675 active site 794851002676 HIGH motif; other site 794851002677 KMSKS motif; other site 794851002678 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 794851002679 anticodon binding site; other site 794851002680 tRNA binding surface [nucleotide binding]; other site 794851002681 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 794851002682 dimer interface [polypeptide binding]; other site 794851002683 putative tRNA-binding site [nucleotide binding]; other site 794851002684 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 794851002685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851002686 S-adenosylmethionine binding site [chemical binding]; other site 794851002687 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 794851002688 Mechanosensitive ion channel; Region: MS_channel; pfam00924 794851002689 Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211 794851002690 GMP synthase; Reviewed; Region: guaA; PRK00074 794851002691 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 794851002692 AMP/PPi binding site [chemical binding]; other site 794851002693 candidate oxyanion hole; other site 794851002694 catalytic triad [active] 794851002695 potential glutamine specificity residues [chemical binding]; other site 794851002696 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 794851002697 ATP Binding subdomain [chemical binding]; other site 794851002698 Ligand Binding sites [chemical binding]; other site 794851002699 Dimerization subdomain; other site 794851002700 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 794851002701 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 794851002702 molybdopterin cofactor binding site [chemical binding]; other site 794851002703 substrate binding site [chemical binding]; other site 794851002704 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 794851002705 molybdopterin cofactor binding site; other site 794851002706 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 794851002707 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 794851002708 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 794851002709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 794851002710 catalytic residue [active] 794851002711 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 794851002712 nucleotide binding site/active site [active] 794851002713 HIT family signature motif; other site 794851002714 catalytic residue [active] 794851002715 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 794851002716 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 794851002717 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 794851002718 dimer interface [polypeptide binding]; other site 794851002719 motif 1; other site 794851002720 active site 794851002721 motif 2; other site 794851002722 motif 3; other site 794851002723 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 794851002724 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 794851002725 putative tRNA-binding site [nucleotide binding]; other site 794851002726 tRNA synthetase B5 domain; Region: B5; pfam03484 794851002727 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 794851002728 dimer interface [polypeptide binding]; other site 794851002729 motif 1; other site 794851002730 motif 3; other site 794851002731 motif 2; other site 794851002732 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 794851002733 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 794851002734 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 794851002735 hinge; other site 794851002736 active site 794851002737 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 794851002738 LytB protein; Region: LYTB; pfam02401 794851002739 ribosomal protein S1; Region: rpsA; TIGR00717 794851002740 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 794851002741 RNA binding site [nucleotide binding]; other site 794851002742 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 794851002743 RNA binding site [nucleotide binding]; other site 794851002744 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 794851002745 RNA binding site [nucleotide binding]; other site 794851002746 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 794851002747 RNA binding site [nucleotide binding]; other site 794851002748 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 794851002749 RNA binding site [nucleotide binding]; other site 794851002750 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 794851002751 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 794851002752 ligand binding site [chemical binding]; other site 794851002753 NAD binding site [chemical binding]; other site 794851002754 dimerization interface [polypeptide binding]; other site 794851002755 catalytic site [active] 794851002756 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 794851002757 putative L-serine binding site [chemical binding]; other site 794851002758 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 794851002759 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 794851002760 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 794851002761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 794851002762 catalytic residue [active] 794851002763 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 794851002764 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 794851002765 putative active site [active] 794851002766 putative metal binding site [ion binding]; other site 794851002767 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 794851002768 putative CheA interaction surface; other site 794851002769 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 794851002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851002771 active site 794851002772 phosphorylation site [posttranslational modification] 794851002773 intermolecular recognition site; other site 794851002774 dimerization interface [polypeptide binding]; other site 794851002775 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 794851002776 putative binding surface; other site 794851002777 active site 794851002778 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 794851002779 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 794851002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851002781 ATP binding site [chemical binding]; other site 794851002782 Mg2+ binding site [ion binding]; other site 794851002783 G-X-G motif; other site 794851002784 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 794851002785 Response regulator receiver domain; Region: Response_reg; pfam00072 794851002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851002787 active site 794851002788 phosphorylation site [posttranslational modification] 794851002789 intermolecular recognition site; other site 794851002790 dimerization interface [polypeptide binding]; other site 794851002791 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 794851002792 putative CheA interaction surface; other site 794851002793 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 794851002794 dimer interface [polypeptide binding]; other site 794851002795 catalytic triad [active] 794851002796 peroxidatic and resolving cysteines [active] 794851002797 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 794851002798 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 794851002799 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 794851002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851002801 S-adenosylmethionine binding site [chemical binding]; other site 794851002802 primosome assembly protein PriA; Validated; Region: PRK05580 794851002803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851002804 ATP binding site [chemical binding]; other site 794851002805 putative Mg++ binding site [ion binding]; other site 794851002806 helicase superfamily c-terminal domain; Region: HELICc; smart00490 794851002807 Sporulation related domain; Region: SPOR; pfam05036 794851002808 Peptidase family M48; Region: Peptidase_M48; pfam01435 794851002809 HemK family putative methylases; Region: hemK_fam; TIGR00536 794851002810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 794851002811 glutamate dehydrogenase; Provisional; Region: PRK09414 794851002812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 794851002813 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 794851002814 NAD(P) binding site [chemical binding]; other site 794851002815 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 794851002816 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 794851002817 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 794851002818 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 794851002819 catalytic residues [active] 794851002820 ferrochelatase; Region: hemH; TIGR00109 794851002821 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 794851002822 C-terminal domain interface [polypeptide binding]; other site 794851002823 active site 794851002824 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 794851002825 active site 794851002826 N-terminal domain interface [polypeptide binding]; other site 794851002827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 794851002828 RNA methyltransferase, RsmE family; Region: TIGR00046 794851002829 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002830 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 794851002831 trimer interface [polypeptide binding]; other site 794851002832 active site 794851002833 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 794851002834 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 794851002835 carboxyltransferase (CT) interaction site; other site 794851002836 biotinylation site [posttranslational modification]; other site 794851002837 biotin carboxylase; Validated; Region: PRK08462 794851002838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 794851002839 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 794851002840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 794851002841 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851002842 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 794851002843 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 794851002844 inhibitor-cofactor binding pocket; inhibition site 794851002845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851002846 catalytic residue [active] 794851002847 potential protein location (hypothetical protein HPSAT_05200 [Helicobacter pylori Sat464]) that overlaps RNA (tRNA-L) 794851002848 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 794851002849 dimer interface [polypeptide binding]; other site 794851002850 putative radical transfer pathway; other site 794851002851 diiron center [ion binding]; other site 794851002852 tyrosyl radical; other site 794851002853 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 794851002854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851002855 S-adenosylmethionine binding site [chemical binding]; other site 794851002856 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 794851002857 Predicted permeases [General function prediction only]; Region: COG0795 794851002858 tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071 794851002859 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 794851002860 dimerization interface 3.5A [polypeptide binding]; other site 794851002861 active site 794851002862 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 794851002863 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 794851002864 NAD binding site [chemical binding]; other site 794851002865 homodimer interface [polypeptide binding]; other site 794851002866 active site 794851002867 substrate binding site [chemical binding]; other site 794851002868 potential protein location (hypothetical protein HPSAT_05230 [Helicobacter pylori Sat464]) that overlaps RNA (tRNA-I) 794851002869 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 794851002870 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 794851002871 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 794851002872 putative NAD(P) binding site [chemical binding]; other site 794851002873 homodimer interface [polypeptide binding]; other site 794851002874 homotetramer interface [polypeptide binding]; other site 794851002875 active site 794851002876 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851002877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851002878 binding surface 794851002879 TPR motif; other site 794851002880 Sel1-like repeats; Region: SEL1; smart00671 794851002881 Sel1 repeat; Region: Sel1; cl02723 794851002882 Sel1-like repeats; Region: SEL1; smart00671 794851002883 Entner-Doudoroff aldolase; Region: eda; TIGR01182 794851002884 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 794851002885 active site 794851002886 intersubunit interface [polypeptide binding]; other site 794851002887 catalytic residue [active] 794851002888 phosphogluconate dehydratase; Validated; Region: PRK09054 794851002889 6-phosphogluconate dehydratase; Region: edd; TIGR01196 794851002890 Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364 794851002891 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 794851002892 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 794851002893 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 794851002894 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 794851002895 putative active site [active] 794851002896 glucokinase, proteobacterial type; Region: glk; TIGR00749 794851002897 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 794851002898 nucleotide binding site [chemical binding]; other site 794851002899 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 794851002900 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 794851002901 putative NAD(P) binding site [chemical binding]; other site 794851002902 putative substrate binding site [chemical binding]; other site 794851002903 catalytic Zn binding site [ion binding]; other site 794851002904 structural Zn binding site [ion binding]; other site 794851002905 dimer interface [polypeptide binding]; other site 794851002906 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851002907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 794851002908 active site 794851002909 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851002910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 794851002911 active site 794851002912 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002913 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 794851002914 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 794851002915 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 794851002916 4Fe-4S binding domain; Region: Fer4; pfam00037 794851002917 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 794851002918 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 794851002919 dimer interface [polypeptide binding]; other site 794851002920 PYR/PP interface [polypeptide binding]; other site 794851002921 TPP binding site [chemical binding]; other site 794851002922 substrate binding site [chemical binding]; other site 794851002923 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 794851002924 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 794851002925 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 794851002926 TPP-binding site [chemical binding]; other site 794851002927 putative dimer interface [polypeptide binding]; other site 794851002928 adenylosuccinate lyase; Provisional; Region: PRK08470 794851002929 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 794851002930 tetramer interface [polypeptide binding]; other site 794851002931 active site 794851002932 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 794851002933 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851002934 excinuclease ABC subunit B; Provisional; Region: PRK05298 794851002935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851002936 ATP binding site [chemical binding]; other site 794851002937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 794851002938 putative Mg++ binding site [ion binding]; other site 794851002939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851002940 nucleotide binding region [chemical binding]; other site 794851002941 ATP-binding site [chemical binding]; other site 794851002942 Ultra-violet resistance protein B; Region: UvrB; pfam12344 794851002943 UvrB/uvrC motif; Region: UVR; pfam02151 794851002944 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 794851002945 Protein of unknown function (DUF3519); Region: DUF3519; pfam12033 794851002946 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 794851002947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851002948 binding surface 794851002949 TPR motif; other site 794851002950 Sel1-like repeats; Region: SEL1; smart00671 794851002951 Sel1-like repeats; Region: SEL1; smart00671 794851002952 Sel1 repeat; Region: Sel1; cl02723 794851002953 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 794851002954 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 794851002955 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 794851002956 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 794851002957 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 794851002958 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 794851002959 cofactor binding site; other site 794851002960 DNA binding site [nucleotide binding] 794851002961 substrate interaction site [chemical binding]; other site 794851002962 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 794851002963 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 794851002964 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 794851002965 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 794851002966 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 794851002967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 794851002968 ligand binding site [chemical binding]; other site 794851002969 translocation protein TolB; Provisional; Region: tolB; PRK04043 794851002970 TolB amino-terminal domain; Region: TolB_N; pfam04052 794851002971 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 794851002972 TonB C terminal; Region: TonB_2; pfam13103 794851002973 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 794851002974 TolR protein; Region: tolR; TIGR02801 794851002975 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 794851002976 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 794851002977 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 794851002978 gamma subunit interface [polypeptide binding]; other site 794851002979 epsilon subunit interface [polypeptide binding]; other site 794851002980 LBP interface [polypeptide binding]; other site 794851002981 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 794851002982 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 794851002983 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 794851002984 alpha subunit interaction interface [polypeptide binding]; other site 794851002985 Walker A motif; other site 794851002986 ATP binding site [chemical binding]; other site 794851002987 Walker B motif; other site 794851002988 inhibitor binding site; inhibition site 794851002989 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 794851002990 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 794851002991 core domain interface [polypeptide binding]; other site 794851002992 delta subunit interface [polypeptide binding]; other site 794851002993 epsilon subunit interface [polypeptide binding]; other site 794851002994 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 794851002995 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 794851002996 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 794851002997 beta subunit interaction interface [polypeptide binding]; other site 794851002998 Walker A motif; other site 794851002999 ATP binding site [chemical binding]; other site 794851003000 Walker B motif; other site 794851003001 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 794851003002 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13431 794851003003 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 794851003004 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 794851003005 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 794851003006 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 794851003007 ParB-like nuclease domain; Region: ParB; smart00470 794851003008 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 794851003009 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 794851003010 P-loop; other site 794851003011 Magnesium ion binding site [ion binding]; other site 794851003012 biotin--protein ligase; Provisional; Region: PRK08477 794851003013 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 794851003014 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 794851003015 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 794851003016 putative active site [active] 794851003017 substrate binding site [chemical binding]; other site 794851003018 putative cosubstrate binding site; other site 794851003019 catalytic site [active] 794851003020 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 794851003021 substrate binding site [chemical binding]; other site 794851003022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 794851003023 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 794851003024 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 794851003025 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 794851003026 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 794851003027 RimM N-terminal domain; Region: RimM; pfam01782 794851003028 PRC-barrel domain; Region: PRC; pfam05239 794851003029 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 794851003030 KH domain; Region: KH_4; pfam13083 794851003031 G-X-X-G motif; other site 794851003032 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 794851003033 signal recognition particle protein; Provisional; Region: PRK10867 794851003034 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 794851003035 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 794851003036 P loop; other site 794851003037 GTP binding site [chemical binding]; other site 794851003038 Signal peptide binding domain; Region: SRP_SPB; pfam02978 794851003039 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 794851003040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 794851003041 active site 794851003042 HIGH motif; other site 794851003043 nucleotide binding site [chemical binding]; other site 794851003044 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 794851003045 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 794851003046 active site 794851003047 KMSKS motif; other site 794851003048 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 794851003049 anticodon binding site; other site 794851003050 flagellar assembly protein FliW; Provisional; Region: PRK13283 794851003051 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 794851003052 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 794851003053 active site 794851003054 homodimer interface [polypeptide binding]; other site 794851003055 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003056 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003057 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 794851003058 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 794851003059 potential frameshift: common BLAST hit: gi|188527943|ref|YP_001910630.1| cell filamentation protein 794851003060 metal-binding heat shock protein; Provisional; Region: PRK00016 794851003061 flavodoxin FldA; Validated; Region: PRK09267 794851003062 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 794851003063 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 794851003064 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 794851003065 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 794851003066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 794851003067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 794851003068 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 794851003069 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 794851003070 active site 794851003071 dimer interface [polypeptide binding]; other site 794851003072 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 794851003073 dimer interface [polypeptide binding]; other site 794851003074 active site 794851003075 Putative outer membrane protein; Region: HP_OMP_2; pfam02521 794851003076 carbon starvation protein A; Provisional; Region: PRK15015 794851003077 Carbon starvation protein CstA; Region: CstA; pfam02554 794851003078 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 794851003079 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 794851003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851003081 dimer interface [polypeptide binding]; other site 794851003082 conserved gate region; other site 794851003083 putative PBP binding loops; other site 794851003084 ABC-ATPase subunit interface; other site 794851003085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851003086 dimer interface [polypeptide binding]; other site 794851003087 conserved gate region; other site 794851003088 putative PBP binding loops; other site 794851003089 ABC-ATPase subunit interface; other site 794851003090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 794851003091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 794851003092 Walker A/P-loop; other site 794851003093 ATP binding site [chemical binding]; other site 794851003094 Q-loop/lid; other site 794851003095 ABC transporter signature motif; other site 794851003096 Walker B; other site 794851003097 D-loop; other site 794851003098 H-loop/switch region; other site 794851003099 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 794851003100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 794851003101 substrate binding pocket [chemical binding]; other site 794851003102 membrane-bound complex binding site; other site 794851003103 hinge residues; other site 794851003104 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 794851003105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851003106 putative substrate translocation pore; other site 794851003107 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 794851003108 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003109 purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107 794851003110 phosphopentomutase; Provisional; Region: PRK05362 794851003111 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 794851003112 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 794851003113 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 794851003114 Nucleoside recognition; Region: Gate; pfam07670 794851003115 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 794851003116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851003117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 794851003118 putative substrate translocation pore; other site 794851003119 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 794851003120 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 794851003121 Ligand Binding Site [chemical binding]; other site 794851003122 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 794851003123 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 794851003124 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 794851003125 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 794851003126 putative arabinose transporter; Provisional; Region: PRK03545 794851003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 794851003128 putative substrate translocation pore; other site 794851003129 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 794851003130 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 794851003131 active site 794851003132 zinc binding site [ion binding]; other site 794851003133 Predicted DNA binding protein [General function prediction only]; Region: COG3413 794851003134 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 794851003135 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 794851003136 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 794851003137 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 794851003138 dimer interface [polypeptide binding]; other site 794851003139 motif 1; other site 794851003140 active site 794851003141 motif 2; other site 794851003142 motif 3; other site 794851003143 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 794851003144 anticodon binding site; other site 794851003145 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 794851003146 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 794851003147 putative active site [active] 794851003148 elongation factor G; Reviewed; Region: PRK00007 794851003149 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 794851003150 G1 box; other site 794851003151 putative GEF interaction site [polypeptide binding]; other site 794851003152 GTP/Mg2+ binding site [chemical binding]; other site 794851003153 Switch I region; other site 794851003154 G2 box; other site 794851003155 G3 box; other site 794851003156 Switch II region; other site 794851003157 G4 box; other site 794851003158 G5 box; other site 794851003159 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 794851003160 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 794851003161 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 794851003162 30S ribosomal protein S7; Validated; Region: PRK05302 794851003163 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 794851003164 S17 interaction site [polypeptide binding]; other site 794851003165 S8 interaction site; other site 794851003166 16S rRNA interaction site [nucleotide binding]; other site 794851003167 streptomycin interaction site [chemical binding]; other site 794851003168 23S rRNA interaction site [nucleotide binding]; other site 794851003169 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 794851003170 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 794851003171 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 794851003172 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 794851003173 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 794851003174 RPB11 interaction site [polypeptide binding]; other site 794851003175 RPB12 interaction site [polypeptide binding]; other site 794851003176 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 794851003177 RPB3 interaction site [polypeptide binding]; other site 794851003178 RPB1 interaction site [polypeptide binding]; other site 794851003179 RPB11 interaction site [polypeptide binding]; other site 794851003180 RPB10 interaction site [polypeptide binding]; other site 794851003181 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 794851003182 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 794851003183 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 794851003184 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 794851003185 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 794851003186 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 794851003187 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 794851003188 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 794851003189 DNA binding site [nucleotide binding] 794851003190 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 794851003191 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 794851003192 core dimer interface [polypeptide binding]; other site 794851003193 peripheral dimer interface [polypeptide binding]; other site 794851003194 L10 interface [polypeptide binding]; other site 794851003195 L11 interface [polypeptide binding]; other site 794851003196 putative EF-Tu interaction site [polypeptide binding]; other site 794851003197 putative EF-G interaction site [polypeptide binding]; other site 794851003198 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 794851003199 23S rRNA interface [nucleotide binding]; other site 794851003200 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 794851003201 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 794851003202 mRNA/rRNA interface [nucleotide binding]; other site 794851003203 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 794851003204 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 794851003205 23S rRNA interface [nucleotide binding]; other site 794851003206 L7/L12 interface [polypeptide binding]; other site 794851003207 putative thiostrepton binding site; other site 794851003208 L25 interface [polypeptide binding]; other site 794851003209 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 794851003210 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 794851003211 putative homodimer interface [polypeptide binding]; other site 794851003212 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 794851003213 heterodimer interface [polypeptide binding]; other site 794851003214 homodimer interface [polypeptide binding]; other site 794851003215 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 794851003216 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 794851003217 elongation factor Tu; Reviewed; Region: PRK00049 794851003218 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 794851003219 G1 box; other site 794851003220 GEF interaction site [polypeptide binding]; other site 794851003221 GTP/Mg2+ binding site [chemical binding]; other site 794851003222 Switch I region; other site 794851003223 G2 box; other site 794851003224 G3 box; other site 794851003225 Switch II region; other site 794851003226 G4 box; other site 794851003227 G5 box; other site 794851003228 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 794851003229 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 794851003230 Antibiotic Binding Site [chemical binding]; other site 794851003231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 794851003232 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 794851003233 Walker A/P-loop; other site 794851003234 ATP binding site [chemical binding]; other site 794851003235 Q-loop/lid; other site 794851003236 ABC transporter signature motif; other site 794851003237 Walker B; other site 794851003238 D-loop; other site 794851003239 H-loop/switch region; other site 794851003240 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 794851003241 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 794851003242 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 794851003243 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 794851003244 Helicobacter pylori IceA2 protein; Region: IceA2; pfam05862 794851003245 serine O-acetyltransferase; Region: cysE; TIGR01172 794851003246 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 794851003247 trimer interface [polypeptide binding]; other site 794851003248 active site 794851003249 substrate binding site [chemical binding]; other site 794851003250 CoA binding site [chemical binding]; other site 794851003251 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 794851003252 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 794851003253 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 794851003254 oligomer interface [polypeptide binding]; other site 794851003255 RNA binding site [nucleotide binding]; other site 794851003256 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 794851003257 oligomer interface [polypeptide binding]; other site 794851003258 RNA binding site [nucleotide binding]; other site 794851003259 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 794851003260 putative nucleic acid binding region [nucleotide binding]; other site 794851003261 G-X-X-G motif; other site 794851003262 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 794851003263 RNA binding site [nucleotide binding]; other site 794851003264 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 794851003265 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 794851003266 Organic solvent tolerance protein; Region: OstA_C; pfam04453 794851003267 Predicted membrane protein/domain [Function unknown]; Region: COG1714 794851003268 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 794851003269 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 794851003270 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 794851003271 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 794851003272 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 794851003273 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 794851003274 Walker A/P-loop; other site 794851003275 ATP binding site [chemical binding]; other site 794851003276 Q-loop/lid; other site 794851003277 ABC transporter signature motif; other site 794851003278 Walker B; other site 794851003279 D-loop; other site 794851003280 H-loop/switch region; other site 794851003281 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 794851003282 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 794851003283 catalytic residue [active] 794851003284 putative FPP diphosphate binding site; other site 794851003285 putative FPP binding hydrophobic cleft; other site 794851003286 dimer interface [polypeptide binding]; other site 794851003287 putative IPP diphosphate binding site; other site 794851003288 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 794851003289 FAD binding domain; Region: FAD_binding_4; pfam01565 794851003290 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 794851003291 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 794851003292 active site residue [active] 794851003293 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 794851003294 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 794851003295 active site 794851003296 camphor resistance protein CrcB; Provisional; Region: PRK14204 794851003297 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 794851003298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851003299 FeS/SAM binding site; other site 794851003300 HemN C-terminal domain; Region: HemN_C; pfam06969 794851003301 Cytochrome c553 [Energy production and conversion]; Region: COG2863 794851003302 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 794851003303 putative active site [active] 794851003304 Ap4A binding site [chemical binding]; other site 794851003305 nudix motif; other site 794851003306 putative metal binding site [ion binding]; other site 794851003307 aspartate kinase; Reviewed; Region: PRK06635 794851003308 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 794851003309 putative nucleotide binding site [chemical binding]; other site 794851003310 putative catalytic residues [active] 794851003311 putative Mg ion binding site [ion binding]; other site 794851003312 putative aspartate binding site [chemical binding]; other site 794851003313 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 794851003314 putative allosteric regulatory site; other site 794851003315 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 794851003316 putative allosteric regulatory residue; other site 794851003317 DNA replication regulator; Region: HobA; pfam12163 794851003318 DNA polymerase III subunit delta'; Validated; Region: PRK08485 794851003319 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 794851003320 dihydropteroate synthase; Region: DHPS; TIGR01496 794851003321 substrate binding pocket [chemical binding]; other site 794851003322 dimer interface [polypeptide binding]; other site 794851003323 inhibitor binding site; inhibition site 794851003324 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 794851003325 EamA-like transporter family; Region: EamA; pfam00892 794851003326 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 794851003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 794851003328 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 794851003329 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 794851003330 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 794851003331 catalytic site [active] 794851003332 subunit interface [polypeptide binding]; other site 794851003333 formamidase; Provisional; Region: amiF; PRK13287 794851003334 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 794851003335 multimer interface [polypeptide binding]; other site 794851003336 active site 794851003337 catalytic triad [active] 794851003338 dimer interface [polypeptide binding]; other site 794851003339 Maf-like protein; Reviewed; Region: PRK04056 794851003340 putative active site [active] 794851003341 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 794851003342 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 794851003343 motif 1; other site 794851003344 active site 794851003345 motif 2; other site 794851003346 motif 3; other site 794851003347 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 794851003348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 794851003349 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003350 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 794851003351 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 794851003352 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 794851003353 dimer interface [polypeptide binding]; other site 794851003354 ssDNA binding site [nucleotide binding]; other site 794851003355 tetramer (dimer of dimers) interface [polypeptide binding]; other site 794851003356 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 794851003357 DNA polymerase III subunit delta; Validated; Region: PRK08487 794851003358 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 794851003359 Exoribonuclease R [Transcription]; Region: VacB; COG0557 794851003360 RNB domain; Region: RNB; pfam00773 794851003361 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 794851003362 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 794851003363 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 794851003364 shikimate binding site; other site 794851003365 NAD(P) binding site [chemical binding]; other site 794851003366 Bacterial SH3 domain; Region: SH3_3; pfam08239 794851003367 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 794851003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 794851003369 dimer interface [polypeptide binding]; other site 794851003370 conserved gate region; other site 794851003371 putative PBP binding loops; other site 794851003372 ABC-ATPase subunit interface; other site 794851003373 potential frameshift: common BLAST hit: gi|210135411|ref|YP_002301850.1| oligopeptide ABC transporter periplasmic oligopeptide-binding 794851003374 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 794851003375 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 794851003376 active site 794851003377 HIGH motif; other site 794851003378 dimer interface [polypeptide binding]; other site 794851003379 KMSKS motif; other site 794851003380 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 794851003381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851003382 S-adenosylmethionine binding site [chemical binding]; other site 794851003383 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 794851003384 ribosome recycling factor; Reviewed; Region: frr; PRK00083 794851003385 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 794851003386 hinge region; other site 794851003387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 794851003388 active site 794851003389 RDD family; Region: RDD; pfam06271 794851003390 potential frameshift: common BLAST hit: gi|210135418|ref|YP_002301857.1| NAD-dependent deacetylase 794851003391 NADH dehydrogenase subunit A; Validated; Region: PRK08489 794851003392 NADH dehydrogenase subunit B; Validated; Region: PRK06411 794851003393 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 794851003394 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 794851003395 NADH dehydrogenase subunit D; Validated; Region: PRK06075 794851003396 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 794851003397 NADH dehydrogenase subunit G; Validated; Region: PRK08493 794851003398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 794851003399 catalytic loop [active] 794851003400 iron binding site [ion binding]; other site 794851003401 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 794851003402 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 794851003403 molybdopterin cofactor binding site; other site 794851003404 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 794851003405 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 794851003406 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 794851003407 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 794851003408 4Fe-4S binding domain; Region: Fer4; cl02805 794851003409 4Fe-4S binding domain; Region: Fer4; pfam00037 794851003410 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 794851003411 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 794851003412 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 794851003413 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 794851003414 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 794851003415 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 794851003416 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 794851003417 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 794851003418 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 794851003419 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 794851003420 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 794851003421 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 794851003422 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 794851003423 active site 794851003424 substrate binding site [chemical binding]; other site 794851003425 metal binding site [ion binding]; metal-binding site 794851003426 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 794851003427 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 794851003428 substrate binding site [chemical binding]; other site 794851003429 active site 794851003430 catalytic residues [active] 794851003431 heterodimer interface [polypeptide binding]; other site 794851003432 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 794851003433 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 794851003434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 794851003435 catalytic residue [active] 794851003436 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 794851003437 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 794851003438 active site 794851003439 ribulose/triose binding site [chemical binding]; other site 794851003440 phosphate binding site [ion binding]; other site 794851003441 substrate (anthranilate) binding pocket [chemical binding]; other site 794851003442 product (indole) binding pocket [chemical binding]; other site 794851003443 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 794851003444 active site 794851003445 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 794851003446 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 794851003447 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 794851003448 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 794851003449 Glutamine amidotransferase class-I; Region: GATase; pfam00117 794851003450 glutamine binding [chemical binding]; other site 794851003451 catalytic triad [active] 794851003452 anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565 794851003453 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 794851003454 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 794851003455 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 794851003456 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 794851003457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 794851003458 active site 794851003459 motif I; other site 794851003460 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 794851003461 motif II; other site 794851003462 Uncharacterized conserved protein [Function unknown]; Region: COG2353 794851003463 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 794851003464 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 794851003465 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 794851003466 Thiamine pyrophosphokinase; Region: TPK; cd07995 794851003467 active site 794851003468 dimerization interface [polypeptide binding]; other site 794851003469 thiamine binding site [chemical binding]; other site 794851003470 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 794851003471 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 794851003472 alphaNTD homodimer interface [polypeptide binding]; other site 794851003473 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 794851003474 alphaNTD - beta interaction site [polypeptide binding]; other site 794851003475 alphaNTD - beta' interaction site [polypeptide binding]; other site 794851003476 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 794851003477 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 794851003478 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 794851003479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 794851003480 RNA binding surface [nucleotide binding]; other site 794851003481 30S ribosomal protein S11; Validated; Region: PRK05309 794851003482 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 794851003483 30S ribosomal protein S13; Region: bact_S13; TIGR03631 794851003484 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 794851003485 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 794851003486 rRNA binding site [nucleotide binding]; other site 794851003487 predicted 30S ribosome binding site; other site 794851003488 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 794851003489 active site 794851003490 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 794851003491 SecY translocase; Region: SecY; pfam00344 794851003492 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 794851003493 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 794851003494 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 794851003495 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 794851003496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 794851003497 23S rRNA interface [nucleotide binding]; other site 794851003498 5S rRNA interface [nucleotide binding]; other site 794851003499 L27 interface [polypeptide binding]; other site 794851003500 L5 interface [polypeptide binding]; other site 794851003501 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 794851003502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 794851003503 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 794851003504 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 794851003505 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 794851003506 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 794851003507 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 794851003508 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 794851003509 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 794851003510 RNA binding site [nucleotide binding]; other site 794851003511 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 794851003512 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 794851003513 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 794851003514 putative translocon interaction site; other site 794851003515 23S rRNA interface [nucleotide binding]; other site 794851003516 signal recognition particle (SRP54) interaction site; other site 794851003517 L23 interface [polypeptide binding]; other site 794851003518 trigger factor interaction site; other site 794851003519 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 794851003520 23S rRNA interface [nucleotide binding]; other site 794851003521 5S rRNA interface [nucleotide binding]; other site 794851003522 putative antibiotic binding site [chemical binding]; other site 794851003523 L25 interface [polypeptide binding]; other site 794851003524 L27 interface [polypeptide binding]; other site 794851003525 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 794851003526 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 794851003527 G-X-X-G motif; other site 794851003528 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 794851003529 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 794851003530 putative translocon binding site; other site 794851003531 protein-rRNA interface [nucleotide binding]; other site 794851003532 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 794851003533 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 794851003534 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 794851003535 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 794851003536 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 794851003537 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 794851003538 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 794851003539 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 794851003540 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 794851003541 AAA domain; Region: AAA_14; pfam13173 794851003542 Helix-turn-helix domain; Region: HTH_36; pfam13730 794851003543 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 794851003544 RNA/DNA hybrid binding site [nucleotide binding]; other site 794851003545 active site 794851003546 fumarate hydratase; Reviewed; Region: fumC; PRK00485 794851003547 Class II fumarases; Region: Fumarase_classII; cd01362 794851003548 active site 794851003549 tetramer interface [polypeptide binding]; other site 794851003550 YtkA-like; Region: YtkA; pfam13115 794851003551 Outer membrane efflux protein; Region: OEP; pfam02321 794851003552 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 794851003553 HlyD family secretion protein; Region: HlyD_3; pfam13437 794851003554 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 794851003555 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 794851003556 AzlC protein; Region: AzlC; cl00570 794851003557 chaperone protein DnaJ; Provisional; Region: PRK14288 794851003558 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 794851003559 HSP70 interaction site [polypeptide binding]; other site 794851003560 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 794851003561 substrate binding site [polypeptide binding]; other site 794851003562 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 794851003563 Zn binding sites [ion binding]; other site 794851003564 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 794851003565 substrate binding site [polypeptide binding]; other site 794851003566 dimer interface [polypeptide binding]; other site 794851003567 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 794851003568 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 794851003569 Ligand Binding Site [chemical binding]; other site 794851003570 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 794851003571 HSP70 interaction site [polypeptide binding]; other site 794851003572 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 794851003573 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 794851003574 active site 794851003575 (T/H)XGH motif; other site 794851003576 nickel responsive regulator; Provisional; Region: PRK00630 794851003577 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 794851003578 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 794851003579 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 794851003580 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 794851003581 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 794851003582 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 794851003583 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 794851003584 potential frameshift: common BLAST hit: gi|15645955|ref|NP_208134.1| outer membrane protein (omp29) 794851003585 potential frameshift: common BLAST hit: gi|15612326|ref|NP_223979.1| putative Outer membrane protein 794851003586 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 794851003587 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 794851003588 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 794851003589 Cl binding site [ion binding]; other site 794851003590 oligomer interface [polypeptide binding]; other site 794851003591 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 794851003592 Phosphoglycerate kinase; Region: PGK; pfam00162 794851003593 substrate binding site [chemical binding]; other site 794851003594 hinge regions; other site 794851003595 ADP binding site [chemical binding]; other site 794851003596 catalytic site [active] 794851003597 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 794851003598 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 794851003599 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 794851003600 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 794851003601 ligand binding site [chemical binding]; other site 794851003602 active site 794851003603 UGI interface [polypeptide binding]; other site 794851003604 catalytic site [active] 794851003605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 794851003606 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 794851003607 putative acyl-acceptor binding pocket; other site 794851003608 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 794851003609 C-terminal peptidase (prc); Region: prc; TIGR00225 794851003610 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 794851003611 protein binding site [polypeptide binding]; other site 794851003612 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 794851003613 Catalytic dyad [active] 794851003614 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 794851003615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851003616 Predicted helicase [General function prediction only]; Region: COG4889 794851003617 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 794851003618 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 794851003619 dimerization interface [polypeptide binding]; other site 794851003620 active site 794851003621 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 794851003622 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 794851003623 prenyltransferase; Reviewed; Region: ubiA; PRK12874 794851003624 UbiA prenyltransferase family; Region: UbiA; pfam01040 794851003625 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 794851003626 Competence protein; Region: Competence; pfam03772 794851003627 replicative DNA helicase; Provisional; Region: PRK08506 794851003628 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 794851003629 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 794851003630 Walker A motif; other site 794851003631 ATP binding site [chemical binding]; other site 794851003632 Walker B motif; other site 794851003633 DNA binding loops [nucleotide binding] 794851003634 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 794851003635 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 794851003636 putative substrate binding site [chemical binding]; other site 794851003637 putative ATP binding site [chemical binding]; other site 794851003638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 794851003639 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 794851003640 dimer interface [polypeptide binding]; other site 794851003641 phosphorylation site [posttranslational modification] 794851003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 794851003643 ATP binding site [chemical binding]; other site 794851003644 Mg2+ binding site [ion binding]; other site 794851003645 G-X-G motif; other site 794851003646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 794851003647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 794851003648 active site 794851003649 phosphorylation site [posttranslational modification] 794851003650 intermolecular recognition site; other site 794851003651 dimerization interface [polypeptide binding]; other site 794851003652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 794851003653 DNA binding site [nucleotide binding] 794851003654 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 794851003655 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 794851003656 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 794851003657 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851003658 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 794851003659 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851003660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 794851003661 DEAD-like helicases superfamily; Region: DEXDc; smart00487 794851003662 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 794851003663 rod shape-determining protein MreC; Region: MreC; pfam04085 794851003664 rod shape-determining protein MreB; Provisional; Region: PRK13927 794851003665 MreB and similar proteins; Region: MreB_like; cd10225 794851003666 nucleotide binding site [chemical binding]; other site 794851003667 Mg binding site [ion binding]; other site 794851003668 putative protofilament interaction site [polypeptide binding]; other site 794851003669 RodZ interaction site [polypeptide binding]; other site 794851003670 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 794851003671 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 794851003672 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 794851003673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851003674 Walker A motif; other site 794851003675 ATP binding site [chemical binding]; other site 794851003676 Walker B motif; other site 794851003677 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 794851003678 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 794851003679 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 794851003680 active site 794851003681 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 794851003682 flagellar assembly protein FliW; Provisional; Region: PRK13282 794851003683 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 794851003684 ATP-dependent protease La; Region: lon; TIGR00763 794851003685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851003686 Walker A motif; other site 794851003687 ATP binding site [chemical binding]; other site 794851003688 Walker B motif; other site 794851003689 arginine finger; other site 794851003690 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 794851003691 prephenate dehydrogenase; Validated; Region: PRK08507 794851003692 Prephenate dehydrogenase; Region: PDH; pfam02153 794851003693 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 794851003694 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 794851003695 active site 794851003696 substrate binding site [chemical binding]; other site 794851003697 Mg2+ binding site [ion binding]; other site 794851003698 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 794851003699 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 794851003700 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851003701 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851003702 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 794851003703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 794851003704 ATP binding site [chemical binding]; other site 794851003705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 794851003706 putative Mg++ binding site [ion binding]; other site 794851003707 biotin synthase; Provisional; Region: PRK08508 794851003708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851003709 FeS/SAM binding site; other site 794851003710 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 794851003711 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 794851003712 Uncharacterized conserved protein [Function unknown]; Region: COG1479 794851003713 Protein of unknown function DUF262; Region: DUF262; pfam03235 794851003714 Protein of unknown function DUF262; Region: DUF262; pfam03235 794851003715 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 794851003716 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 794851003717 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 794851003718 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 794851003719 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 794851003720 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 794851003721 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 794851003722 Ligand binding site; other site 794851003723 metal-binding site 794851003724 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 794851003725 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 794851003726 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 794851003727 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 794851003728 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 794851003729 Walker A motif/ATP binding site; other site 794851003730 Walker B motif; other site 794851003731 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 794851003732 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 794851003733 ATP binding site [chemical binding]; other site 794851003734 Walker A motif; other site 794851003735 hexamer interface [polypeptide binding]; other site 794851003736 Walker B motif; other site 794851003737 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 794851003738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 794851003739 active site 794851003740 HIGH motif; other site 794851003741 nucleotide binding site [chemical binding]; other site 794851003742 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 794851003743 active site 794851003744 KMSKS motif; other site 794851003745 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 794851003746 tRNA binding surface [nucleotide binding]; other site 794851003747 anticodon binding site; other site 794851003748 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 794851003749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 794851003750 RNA binding surface [nucleotide binding]; other site 794851003751 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 794851003752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 794851003753 FeS/SAM binding site; other site 794851003754 KpsF/GutQ family protein; Region: kpsF; TIGR00393 794851003755 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 794851003756 putative active site [active] 794851003757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 794851003758 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 794851003759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 794851003760 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 794851003761 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 794851003762 dimethyladenosine transferase; Region: ksgA; TIGR00755 794851003763 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851003764 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 794851003765 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851003766 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 794851003767 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 794851003768 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 794851003769 active site 794851003770 substrate binding site [chemical binding]; other site 794851003771 cosubstrate binding site; other site 794851003772 catalytic site [active] 794851003773 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 794851003774 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 794851003775 tandem repeat interface [polypeptide binding]; other site 794851003776 oligomer interface [polypeptide binding]; other site 794851003777 active site residues [active] 794851003778 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 794851003779 TIR domain; Region: TIR_2; pfam13676 794851003780 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 794851003781 active site 794851003782 carbon storage regulator; Provisional; Region: PRK00568 794851003783 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 794851003784 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 794851003785 SmpB-tmRNA interface; other site 794851003786 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 794851003787 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 794851003788 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 794851003789 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 794851003790 ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188 794851003791 hypothetical protein; Provisional; Region: PRK14374 794851003792 membrane protein insertase; Provisional; Region: PRK01318 794851003793 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 794851003794 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 794851003795 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 794851003796 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 794851003797 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 794851003798 GTP/Mg2+ binding site [chemical binding]; other site 794851003799 G4 box; other site 794851003800 G5 box; other site 794851003801 trmE is a tRNA modification GTPase; Region: trmE; cd04164 794851003802 G1 box; other site 794851003803 G1 box; other site 794851003804 GTP/Mg2+ binding site [chemical binding]; other site 794851003805 Switch I region; other site 794851003806 Switch I region; other site 794851003807 G2 box; other site 794851003808 G2 box; other site 794851003809 Switch II region; other site 794851003810 G3 box; other site 794851003811 G3 box; other site 794851003812 Switch II region; other site 794851003813 G4 box; other site 794851003814 G5 box; other site 794851003815 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 794851003816 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003817 LPP20 lipoprotein; Region: LPP20; pfam02169 794851003818 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 794851003819 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 794851003820 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 794851003821 catalytic residues [active] 794851003822 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 794851003823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 794851003824 RNA binding surface [nucleotide binding]; other site 794851003825 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 794851003826 active site 794851003827 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 794851003828 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 794851003829 active site 794851003830 PHP Thumb interface [polypeptide binding]; other site 794851003831 metal binding site [ion binding]; metal-binding site 794851003832 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 794851003833 generic binding surface I; other site 794851003834 generic binding surface II; other site 794851003835 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 794851003836 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 794851003837 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 794851003838 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 794851003839 mce related protein; Region: MCE; pfam02470 794851003840 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 794851003841 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 794851003842 Walker A/P-loop; other site 794851003843 ATP binding site [chemical binding]; other site 794851003844 Q-loop/lid; other site 794851003845 ABC transporter signature motif; other site 794851003846 Walker B; other site 794851003847 D-loop; other site 794851003848 H-loop/switch region; other site 794851003849 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 794851003850 conserved hypothetical integral membrane protein; Region: TIGR00056 794851003851 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003852 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 794851003853 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 794851003854 homodimer interface [polypeptide binding]; other site 794851003855 substrate-cofactor binding pocket; other site 794851003856 catalytic residue [active] 794851003857 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003858 DNA polymerase I; Region: pola; TIGR00593 794851003859 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 794851003860 active site 794851003861 metal binding site 1 [ion binding]; metal-binding site 794851003862 putative 5' ssDNA interaction site; other site 794851003863 metal binding site 3; metal-binding site 794851003864 metal binding site 2 [ion binding]; metal-binding site 794851003865 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 794851003866 putative DNA binding site [nucleotide binding]; other site 794851003867 putative metal binding site [ion binding]; other site 794851003868 3'-5' exonuclease; Region: 35EXOc; smart00474 794851003869 active site 794851003870 substrate binding site [chemical binding]; other site 794851003871 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 794851003872 active site 794851003873 DNA binding site [nucleotide binding] 794851003874 catalytic site [active] 794851003875 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851003876 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 794851003877 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 794851003878 thymidylate kinase; Validated; Region: tmk; PRK00698 794851003879 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 794851003880 TMP-binding site; other site 794851003881 ATP-binding site [chemical binding]; other site 794851003882 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 794851003883 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 794851003884 active site 794851003885 (T/H)XGH motif; other site 794851003886 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 794851003887 Flavoprotein; Region: Flavoprotein; pfam02441 794851003888 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 794851003889 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 794851003890 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 794851003891 Part of AAA domain; Region: AAA_19; pfam13245 794851003892 Family description; Region: UvrD_C_2; pfam13538 794851003893 TPR repeat; Region: TPR_11; pfam13414 794851003894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851003895 TPR motif; other site 794851003896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 794851003897 binding surface 794851003898 TPR motif; other site 794851003899 seryl-tRNA synthetase; Provisional; Region: PRK05431 794851003900 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 794851003901 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 794851003902 dimer interface [polypeptide binding]; other site 794851003903 active site 794851003904 motif 1; other site 794851003905 motif 2; other site 794851003906 motif 3; other site 794851003907 Predicted amidohydrolase [General function prediction only]; Region: COG0388 794851003908 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 794851003909 active site 794851003910 catalytic triad [active] 794851003911 dimer interface [polypeptide binding]; other site 794851003912 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14065 794851003913 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 794851003914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851003915 S-adenosylmethionine binding site [chemical binding]; other site 794851003916 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 794851003917 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 794851003918 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 794851003919 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 794851003920 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 794851003921 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 794851003922 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 794851003923 HlyD family secretion protein; Region: HlyD_3; pfam13437 794851003924 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 794851003925 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 794851003926 Domain of unknown function DUF21; Region: DUF21; pfam01595 794851003927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 794851003928 Transporter associated domain; Region: CorC_HlyC; smart01091 794851003929 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 794851003930 Phosphate transporter family; Region: PHO4; pfam01384 794851003931 NifU-like domain; Region: NifU; pfam01106 794851003932 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 794851003933 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 794851003934 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 794851003935 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 794851003936 putative active site [active] 794851003937 transaldolase; Provisional; Region: PRK03903 794851003938 catalytic residue [active] 794851003939 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 794851003940 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 794851003941 5S rRNA interface [nucleotide binding]; other site 794851003942 CTC domain interface [polypeptide binding]; other site 794851003943 L16 interface [polypeptide binding]; other site 794851003944 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 794851003945 putative active site [active] 794851003946 catalytic residue [active] 794851003947 Predicted permeases [General function prediction only]; Region: COG0795 794851003948 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 794851003949 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 794851003950 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 794851003951 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 794851003952 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 794851003953 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851003954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 794851003955 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 794851003956 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 794851003957 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 794851003958 metal-binding site [ion binding] 794851003959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 794851003960 Soluble P-type ATPase [General function prediction only]; Region: COG4087 794851003961 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 794851003962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 794851003963 S-adenosylmethionine binding site [chemical binding]; other site 794851003964 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 794851003965 catalytic motif [active] 794851003966 Zn binding site [ion binding]; other site 794851003967 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 794851003968 RibD C-terminal domain; Region: RibD_C; cl17279 794851003969 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 794851003970 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 794851003971 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 794851003972 NAD(P) binding pocket [chemical binding]; other site 794851003973 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 794851003974 4Fe-4S binding domain; Region: Fer4_5; pfam12801 794851003975 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 794851003976 acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023 794851003977 FolB domain; Region: folB_dom; TIGR00526 794851003978 active site 794851003979 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 794851003980 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 794851003981 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 794851003982 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 794851003983 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 794851003984 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 794851003985 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 794851003986 NusA N-terminal domain; Region: NusA_N; pfam08529 794851003987 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 794851003988 RNA binding site [nucleotide binding]; other site 794851003989 homodimer interface [polypeptide binding]; other site 794851003990 NusA-like KH domain; Region: KH_5; pfam13184 794851003991 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 794851003992 G-X-X-G motif; other site 794851003993 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 794851003994 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 794851003995 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 794851003996 Restriction endonuclease [Defense mechanisms]; Region: COG3587 794851003997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851003998 ATP binding site [chemical binding]; other site 794851003999 putative Mg++ binding site [ion binding]; other site 794851004000 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 794851004001 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851004002 DNA methylase; Region: N6_N4_Mtase; pfam01555 794851004003 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 794851004004 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 794851004005 ssDNA binding site; other site 794851004006 generic binding surface II; other site 794851004007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851004008 ATP binding site [chemical binding]; other site 794851004009 putative Mg++ binding site [ion binding]; other site 794851004010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851004011 nucleotide binding region [chemical binding]; other site 794851004012 ATP-binding site [chemical binding]; other site 794851004013 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851004014 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 794851004015 active site 794851004016 putative catalytic site [active] 794851004017 DNA binding site [nucleotide binding] 794851004018 putative phosphate binding site [ion binding]; other site 794851004019 metal binding site A [ion binding]; metal-binding site 794851004020 AP binding site [nucleotide binding]; other site 794851004021 metal binding site B [ion binding]; metal-binding site 794851004022 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 794851004023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 794851004024 Walker A motif; other site 794851004025 ATP binding site [chemical binding]; other site 794851004026 Walker B motif; other site 794851004027 arginine finger; other site 794851004028 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 794851004029 DnaA box-binding interface [nucleotide binding]; other site 794851004030 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 794851004031 Protein of unknown function (DUF2443); Region: DUF2443; pfam10398 794851004032 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 794851004033 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 794851004034 glutaminase active site [active] 794851004035 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 794851004036 dimer interface [polypeptide binding]; other site 794851004037 active site 794851004038 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 794851004039 dimer interface [polypeptide binding]; other site 794851004040 active site 794851004041 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 794851004042 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851004043 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 794851004044 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 794851004045 HsdM N-terminal domain; Region: HsdM_N; pfam12161 794851004046 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 794851004047 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 794851004048 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 794851004049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851004050 ATP binding site [chemical binding]; other site 794851004051 putative Mg++ binding site [ion binding]; other site 794851004052 Protein of unknown function DUF45; Region: DUF45; pfam01863 794851004053 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 794851004054 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 794851004055 N-terminal plug; other site 794851004056 ligand-binding site [chemical binding]; other site 794851004057 Arginase family; Region: Arginase; cd09989 794851004058 active site 794851004059 Mn binding site [ion binding]; other site 794851004060 oligomer interface [polypeptide binding]; other site 794851004061 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 794851004062 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 794851004063 hexamer interface [polypeptide binding]; other site 794851004064 ligand binding site [chemical binding]; other site 794851004065 putative active site [active] 794851004066 NAD(P) binding site [chemical binding]; other site 794851004067 Helicobacter outer membrane protein; Region: HP_OMP; pfam01856 794851004068 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 794851004069 ATP-NAD kinase; Region: NAD_kinase; pfam01513 794851004070 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 794851004071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 794851004072 Walker A/P-loop; other site 794851004073 ATP binding site [chemical binding]; other site 794851004074 Q-loop/lid; other site 794851004075 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 794851004076 ABC transporter signature motif; other site 794851004077 Walker B; other site 794851004078 D-loop; other site 794851004079 H-loop/switch region; other site 794851004080 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 794851004081 Domain of unknown function (DUF814); Region: DUF814; pfam05670 794851004082 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 794851004083 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 794851004084 active site 794851004085 catalytic site [active] 794851004086 substrate binding site [chemical binding]; other site 794851004087 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 794851004088 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 794851004089 substrate binding site [chemical binding]; other site 794851004090 hexamer interface [polypeptide binding]; other site 794851004091 metal binding site [ion binding]; metal-binding site 794851004092 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 794851004093 active site 794851004094 Methyltransferase domain; Region: Methyltransf_26; pfam13659 794851004095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 794851004096 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 794851004097 elongation factor Ts; Provisional; Region: tsf; PRK09377 794851004098 UBA/TS-N domain; Region: UBA; pfam00627 794851004099 Elongation factor TS; Region: EF_TS; pfam00889 794851004100 Elongation factor TS; Region: EF_TS; pfam00889 794851004101 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 794851004102 rRNA interaction site [nucleotide binding]; other site 794851004103 S8 interaction site; other site 794851004104 putative laminin-1 binding site; other site 794851004105 putative recombination protein RecB; Provisional; Region: PRK13909 794851004106 Family description; Region: UvrD_C_2; pfam13538 794851004107 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 794851004108 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856 794851004109 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 794851004110 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 794851004111 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 794851004112 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 794851004113 Protein export membrane protein; Region: SecD_SecF; pfam02355 794851004114 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 794851004115 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 794851004116 HIGH motif; other site 794851004117 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 794851004118 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 794851004119 active site 794851004120 KMSKS motif; other site 794851004121 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 794851004122 tRNA binding surface [nucleotide binding]; other site 794851004123 anticodon binding site; other site 794851004124 Lipopolysaccharide-assembly; Region: LptE; pfam04390 794851004125 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 794851004126 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 794851004127 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 794851004128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 794851004129 Peptidase family M23; Region: Peptidase_M23; pfam01551 794851004130 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 794851004131 Peptidase family M23; Region: Peptidase_M23; pfam01551 794851004132 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 794851004133 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 794851004134 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 794851004135 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 794851004136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 794851004137 ATP binding site [chemical binding]; other site 794851004138 putative Mg++ binding site [ion binding]; other site 794851004139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 794851004140 nucleotide binding region [chemical binding]; other site 794851004141 ATP-binding site [chemical binding]; other site 794851004142 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 794851004143 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 794851004144 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 794851004145 iron-sulfur cluster [ion binding]; other site 794851004146 [2Fe-2S] cluster binding site [ion binding]; other site 794851004147 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 794851004148 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 794851004149 intrachain domain interface; other site 794851004150 interchain domain interface [polypeptide binding]; other site 794851004151 heme bH binding site [chemical binding]; other site 794851004152 Qi binding site; other site 794851004153 heme bL binding site [chemical binding]; other site 794851004154 Qo binding site; other site 794851004155 interchain domain interface [polypeptide binding]; other site 794851004156 intrachain domain interface; other site 794851004157 Qi binding site; other site 794851004158 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 794851004159 Qo binding site; other site 794851004160 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 794851004161 Cytochrome c; Region: Cytochrom_C; pfam00034 794851004162 Cytochrome c; Region: Cytochrom_C; cl11414 794851004163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 794851004164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 794851004165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 794851004166 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 794851004167 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 794851004168 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 794851004169 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 794851004170 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 794851004171 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 794851004172 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 794851004173 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 794851004174 putative ligand binding site [chemical binding]; other site 794851004175 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 794851004176 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 794851004177 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 794851004178 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 794851004179 dimer interface [polypeptide binding]; other site 794851004180 decamer (pentamer of dimers) interface [polypeptide binding]; other site 794851004181 catalytic triad [active] 794851004182 peroxidatic and resolving cysteines [active] 794851004183 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 794851004184 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 794851004185 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 794851004186 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 794851004187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 794851004188 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 794851004189 G1 box; other site 794851004190 GTP/Mg2+ binding site [chemical binding]; other site 794851004191 Switch I region; other site 794851004192 G2 box; other site 794851004193 G3 box; other site 794851004194 Switch II region; other site 794851004195 G4 box; other site 794851004196 G5 box; other site 794851004197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 794851004198 OstA-like protein; Region: OstA; pfam03968 794851004199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 794851004200 motif II; other site 794851004201 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 794851004202 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 794851004203 Sporulation related domain; Region: SPOR; pfam05036 794851004204 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 794851004205 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 794851004206 N-acetyl-D-glucosamine binding site [chemical binding]; other site 794851004207 catalytic residue [active] 794851004208 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 794851004209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 794851004210 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 794851004211 active site 794851004212 riboflavin synthase, alpha subunit; Region: ribE; TIGR00187 794851004213 Lumazine binding domain; Region: Lum_binding; pfam00677 794851004214 Lumazine binding domain; Region: Lum_binding; pfam00677 794851004215 flhB C-terminus-related protein; Region: flhB_rel; TIGR00789 794851004216 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 794851004217 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 794851004218 Walker A/P-loop; other site 794851004219 ATP binding site [chemical binding]; other site 794851004220 Q-loop/lid; other site 794851004221 ABC transporter signature motif; other site 794851004222 Walker B; other site 794851004223 D-loop; other site 794851004224 H-loop/switch region; other site 794851004225 NIL domain; Region: NIL; pfam09383 794851004226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 794851004227 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 794851004228 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 794851004229 active site 794851004230 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 794851004231 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 794851004232 Mg++ binding site [ion binding]; other site 794851004233 putative catalytic motif [active] 794851004234 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 794851004235 active site 794851004236 hydrophilic channel; other site 794851004237 dimerization interface [polypeptide binding]; other site 794851004238 catalytic residues [active] 794851004239 active site lid [active] 794851004240 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 794851004241 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 794851004242 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 794851004243 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 794851004244 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 794851004245 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 794851004246 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 794851004247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 794851004248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 794851004249 hypothetical protein; Provisional; Region: PRK10236 794851004250 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 794851004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735