-- dump date   	20140619_114638
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
637913000001	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
637913000002	putative RNA binding site [nucleotide binding]; other site
637913000003	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
637913000004	homopentamer interface [polypeptide binding]; other site
637913000005	active site
637913000006	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
637913000007	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
637913000008	active site clefts [active]
637913000009	zinc binding site [ion binding]; other site
637913000010	dimer interface [polypeptide binding]; other site
637913000011	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
637913000012	active site
637913000013	dimer interface [polypeptide binding]; other site
637913000014	pantoate--beta-alanine ligase; Region: panC; TIGR00018
637913000015	Pantoate-beta-alanine ligase; Region: PanC; cd00560
637913000016	active site
637913000017	ATP-binding site [chemical binding]; other site
637913000018	pantoate-binding site; other site
637913000019	HXXH motif; other site
637913000020	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000021	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
637913000022	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
637913000023	ring oligomerisation interface [polypeptide binding]; other site
637913000024	ATP/Mg binding site [chemical binding]; other site
637913000025	stacking interactions; other site
637913000026	hinge regions; other site
637913000027	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
637913000028	oligomerisation interface [polypeptide binding]; other site
637913000029	mobile loop; other site
637913000030	roof hairpin; other site
637913000031	DNA primase, catalytic core; Region: dnaG; TIGR01391
637913000032	CHC2 zinc finger; Region: zf-CHC2; pfam01807
637913000033	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
637913000034	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
637913000035	active site
637913000036	metal binding site [ion binding]; metal-binding site
637913000037	interdomain interaction site; other site
637913000038	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
637913000039	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
637913000040	Ligand Binding Site [chemical binding]; other site
637913000041	TrbC/VIRB2 family; Region: TrbC; cl01583
637913000042	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
637913000043	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
637913000044	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
637913000045	Walker A motif; other site
637913000046	ATP binding site [chemical binding]; other site
637913000047	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
637913000048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
637913000049	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
637913000050	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637913000051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913000052	active site
637913000053	phosphorylation site [posttranslational modification]
637913000054	intermolecular recognition site; other site
637913000055	dimerization interface [polypeptide binding]; other site
637913000056	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
637913000057	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
637913000058	dimer interface [polypeptide binding]; other site
637913000059	active site
637913000060	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637913000061	catalytic residues [active]
637913000062	substrate binding site [chemical binding]; other site
637913000063	lipid A 1-phosphatase; Reviewed; Region: PRK09597
637913000064	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637913000065	active site
637913000066	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
637913000067	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
637913000068	Sulfatase; Region: Sulfatase; pfam00884
637913000069	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000070	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
637913000071	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
637913000072	dimer interface [polypeptide binding]; other site
637913000073	active site
637913000074	citrylCoA binding site [chemical binding]; other site
637913000075	NADH binding [chemical binding]; other site
637913000076	cationic pore residues; other site
637913000077	oxalacetate/citrate binding site [chemical binding]; other site
637913000078	coenzyme A binding site [chemical binding]; other site
637913000079	catalytic triad [active]
637913000080	isocitrate dehydrogenase; Validated; Region: PRK07362
637913000081	isocitrate dehydrogenase; Reviewed; Region: PRK07006
637913000082	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
637913000083	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
637913000084	AAA domain; Region: AAA_26; pfam13500
637913000085	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
637913000086	Ligand Binding Site [chemical binding]; other site
637913000087	Uncharacterized conserved protein [Function unknown]; Region: COG2127
637913000088	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
637913000089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913000090	Walker A motif; other site
637913000091	ATP binding site [chemical binding]; other site
637913000092	Walker B motif; other site
637913000093	arginine finger; other site
637913000094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913000095	Walker A motif; other site
637913000096	ATP binding site [chemical binding]; other site
637913000097	Walker B motif; other site
637913000098	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
637913000099	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
637913000100	tetramerization interface [polypeptide binding]; other site
637913000101	active site
637913000102	hypothetical protein; Provisional; Region: PRK03762
637913000103	PDZ domain; Region: PDZ_2; pfam13180
637913000104	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
637913000105	Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion]; Region: TrbL; COG3846
637913000106	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
637913000107	Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504
637913000108	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
637913000109	VirB7 interaction site; other site
637913000110	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
637913000111	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
637913000112	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
637913000113	Substrate binding site; other site
637913000114	Cupin domain; Region: Cupin_2; cl17218
637913000115	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
637913000116	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
637913000117	NADP-binding site; other site
637913000118	homotetramer interface [polypeptide binding]; other site
637913000119	substrate binding site [chemical binding]; other site
637913000120	homodimer interface [polypeptide binding]; other site
637913000121	active site
637913000122	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
637913000123	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
637913000124	NADP binding site [chemical binding]; other site
637913000125	active site
637913000126	putative substrate binding site [chemical binding]; other site
637913000127	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
637913000128	dimerization interface [polypeptide binding]; other site
637913000129	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
637913000130	ATP binding site [chemical binding]; other site
637913000131	Acylphosphatase; Region: Acylphosphatase; pfam00708
637913000132	[NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143
637913000133	HypF finger; Region: zf-HYPF; pfam07503
637913000134	HypF finger; Region: zf-HYPF; pfam07503
637913000135	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
637913000136	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957
637913000137	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
637913000138	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913000139	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913000140	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
637913000141	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
637913000142	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
637913000143	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
637913000144	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
637913000145	Na binding site [ion binding]; other site
637913000146	Proline dehydrogenase; Region: Pro_dh; pfam01619
637913000147	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
637913000148	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
637913000149	Glutamate binding site [chemical binding]; other site
637913000150	NAD binding site [chemical binding]; other site
637913000151	catalytic residues [active]
637913000152	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
637913000153	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
637913000154	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
637913000155	Proteins of 100 residues with WXG; Region: WXG100; cl02005
637913000156	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
637913000157	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
637913000158	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
637913000159	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
637913000160	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
637913000161	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
637913000162	G1 box; other site
637913000163	GTP/Mg2+ binding site [chemical binding]; other site
637913000164	G2 box; other site
637913000165	Switch I region; other site
637913000166	G3 box; other site
637913000167	Switch II region; other site
637913000168	G4 box; other site
637913000169	G5 box; other site
637913000170	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
637913000171	UreF; Region: UreF; pfam01730
637913000172	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
637913000173	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
637913000174	dimer interface [polypeptide binding]; other site
637913000175	catalytic residues [active]
637913000176	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
637913000177	urease subunit beta; Provisional; Region: ureB; PRK13985
637913000178	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
637913000179	subunit interactions [polypeptide binding]; other site
637913000180	active site
637913000181	flap region; other site
637913000182	urease subunit alpha; Provisional; Region: PRK13986
637913000183	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
637913000184	alpha-gamma subunit interface [polypeptide binding]; other site
637913000185	beta-gamma subunit interface [polypeptide binding]; other site
637913000186	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
637913000187	gamma-beta subunit interface [polypeptide binding]; other site
637913000188	alpha-beta subunit interface [polypeptide binding]; other site
637913000189	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
637913000190	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324
637913000191	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
637913000192	active site
637913000193	substrate binding site [chemical binding]; other site
637913000194	metal binding site [ion binding]; metal-binding site
637913000195	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
637913000196	peptide chain release factor 1; Validated; Region: prfA; PRK00591
637913000197	This domain is found in peptide chain release factors; Region: PCRF; smart00937
637913000198	RF-1 domain; Region: RF-1; pfam00472
637913000199	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000200	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637913000201	dimer interface [polypeptide binding]; other site
637913000202	putative CheW interface [polypeptide binding]; other site
637913000203	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
637913000204	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
637913000205	23S rRNA interface [nucleotide binding]; other site
637913000206	L3 interface [polypeptide binding]; other site
637913000207	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
637913000208	Predicted dehydrogenase [General function prediction only]; Region: COG0579
637913000209	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
637913000210	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
637913000211	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
637913000212	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
637913000213	NlpC/P60 family; Region: NLPC_P60; pfam00877
637913000214	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
637913000215	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
637913000216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637913000217	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
637913000218	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637913000219	DNA binding residues [nucleotide binding]
637913000220	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
637913000221	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
637913000222	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
637913000223	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
637913000224	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913000225	Methyltransferase domain; Region: Methyltransf_26; pfam13659
637913000226	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913000227	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
637913000228	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
637913000229	putative ligand binding site [chemical binding]; other site
637913000230	putative NAD binding site [chemical binding]; other site
637913000231	catalytic site [active]
637913000232	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
637913000233	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
637913000234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913000235	catalytic residue [active]
637913000236	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637913000237	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637913000238	dimer interface [polypeptide binding]; other site
637913000239	putative CheW interface [polypeptide binding]; other site
637913000240	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
637913000241	Ligand Binding Site [chemical binding]; other site
637913000242	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000243	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
637913000244	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
637913000245	metal-binding site
637913000246	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
637913000247	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
637913000248	dimerization interface [polypeptide binding]; other site
637913000249	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637913000250	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637913000251	dimer interface [polypeptide binding]; other site
637913000252	putative CheW interface [polypeptide binding]; other site
637913000253	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
637913000254	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
637913000255	active site
637913000256	metal binding site [ion binding]; metal-binding site
637913000257	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
637913000258	S-ribosylhomocysteinase; Provisional; Region: PRK02260
637913000259	cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176
637913000260	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
637913000261	homodimer interface [polypeptide binding]; other site
637913000262	substrate-cofactor binding pocket; other site
637913000263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913000264	catalytic residue [active]
637913000265	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
637913000266	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
637913000267	dimer interface [polypeptide binding]; other site
637913000268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913000269	catalytic residue [active]
637913000270	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
637913000271	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
637913000272	nucleotide binding site [chemical binding]; other site
637913000273	NEF interaction site [polypeptide binding]; other site
637913000274	SBD interface [polypeptide binding]; other site
637913000275	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
637913000276	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
637913000277	dimer interface [polypeptide binding]; other site
637913000278	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
637913000279	heat-inducible transcription repressor; Provisional; Region: PRK03911
637913000280	hypothetical protein; Provisional; Region: PRK05834
637913000281	intersubunit interface [polypeptide binding]; other site
637913000282	active site
637913000283	Zn2+ binding site [ion binding]; other site
637913000284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
637913000285	flagellin B; Provisional; Region: PRK13588
637913000286	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637913000287	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637913000288	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637913000289	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
637913000290	DNA topoisomerase I; Validated; Region: PRK05582
637913000291	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
637913000292	active site
637913000293	interdomain interaction site; other site
637913000294	putative metal-binding site [ion binding]; other site
637913000295	nucleotide binding site [chemical binding]; other site
637913000296	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
637913000297	domain I; other site
637913000298	DNA binding groove [nucleotide binding]
637913000299	phosphate binding site [ion binding]; other site
637913000300	domain II; other site
637913000301	domain III; other site
637913000302	nucleotide binding site [chemical binding]; other site
637913000303	catalytic site [active]
637913000304	domain IV; other site
637913000305	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637913000306	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637913000307	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637913000308	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
637913000309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913000310	FeS/SAM binding site; other site
637913000311	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
637913000312	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
637913000313	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
637913000314	phosphoenolpyruvate synthase; Validated; Region: PRK06464
637913000315	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
637913000316	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
637913000317	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
637913000318	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
637913000319	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
637913000320	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
637913000321	active site
637913000322	dimer interface [polypeptide binding]; other site
637913000323	motif 1; other site
637913000324	motif 2; other site
637913000325	motif 3; other site
637913000326	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
637913000327	anticodon binding site; other site
637913000328	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
637913000329	translation initiation factor IF-3; Region: infC; TIGR00168
637913000330	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
637913000331	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
637913000332	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
637913000333	23S rRNA binding site [nucleotide binding]; other site
637913000334	L21 binding site [polypeptide binding]; other site
637913000335	L13 binding site [polypeptide binding]; other site
637913000336	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000337	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
637913000338	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
637913000339	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
637913000340	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
637913000341	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
637913000342	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
637913000343	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
637913000344	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
637913000345	catalytic triad [active]
637913000346	Uncharacterized conserved protein [Function unknown]; Region: COG1556
637913000347	iron-sulfur cluster-binding protein; Region: TIGR00273
637913000348	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
637913000349	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
637913000350	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
637913000351	Cysteine-rich domain; Region: CCG; pfam02754
637913000352	Cysteine-rich domain; Region: CCG; pfam02754
637913000353	L-lactate transport; Region: lctP; TIGR00795
637913000354	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
637913000355	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
637913000356	L-lactate permease; Region: Lactate_perm; pfam02652
637913000357	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
637913000358	helix-hairpin-helix signature motif; other site
637913000359	substrate binding pocket [chemical binding]; other site
637913000360	active site
637913000361	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
637913000362	DNA binding and oxoG recognition site [nucleotide binding]
637913000363	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
637913000364	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
637913000365	transmembrane helices; other site
637913000366	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
637913000367	Low-spin heme binding site [chemical binding]; other site
637913000368	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
637913000369	D-pathway; other site
637913000370	Putative water exit pathway; other site
637913000371	Binuclear center (active site) [active]
637913000372	K-pathway; other site
637913000373	Putative proton exit pathway; other site
637913000374	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
637913000375	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
637913000376	cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736
637913000377	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
637913000378	Cytochrome c; Region: Cytochrom_C; pfam00034
637913000379	Cytochrome c; Region: Cytochrom_C; pfam00034
637913000380	Family of unknown function (DUF4006); Region: DUF4006; pfam13179
637913000381	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
637913000382	recombinase A; Provisional; Region: recA; PRK09354
637913000383	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
637913000384	hexamer interface [polypeptide binding]; other site
637913000385	Walker A motif; other site
637913000386	ATP binding site [chemical binding]; other site
637913000387	Walker B motif; other site
637913000388	enolase; Provisional; Region: eno; PRK00077
637913000389	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
637913000390	dimer interface [polypeptide binding]; other site
637913000391	metal binding site [ion binding]; metal-binding site
637913000392	substrate binding pocket [chemical binding]; other site
637913000393	AMIN domain; Region: AMIN; pfam11741
637913000394	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
637913000395	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
637913000396	ADP binding site [chemical binding]; other site
637913000397	magnesium binding site [ion binding]; other site
637913000398	putative shikimate binding site; other site
637913000399	Cache domain; Region: Cache_1; pfam02743
637913000400	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913000401	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
637913000402	Ligand binding site; other site
637913000403	metal-binding site
637913000404	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913000405	Sel1-like repeats; Region: SEL1; smart00671
637913000406	Sel1-like repeats; Region: SEL1; smart00671
637913000407	Sel1-like repeats; Region: SEL1; smart00671
637913000408	Sel1-like repeats; Region: SEL1; smart00671
637913000409	Sel1-like repeats; Region: SEL1; smart00671
637913000410	Sel1-like repeats; Region: SEL1; smart00671
637913000411	hypothetical protein; Provisional; Region: PRK12378
637913000412	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
637913000413	dimer interface [polypeptide binding]; other site
637913000414	active site
637913000415	Schiff base residues; other site
637913000416	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637913000417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913000418	active site
637913000419	phosphorylation site [posttranslational modification]
637913000420	intermolecular recognition site; other site
637913000421	dimerization interface [polypeptide binding]; other site
637913000422	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637913000423	DNA binding site [nucleotide binding]
637913000424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637913000425	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
637913000426	Peptidase family U32; Region: Peptidase_U32; pfam01136
637913000427	peptide chain release factor 2; Region: prfB; TIGR00020
637913000428	This domain is found in peptide chain release factors; Region: PCRF; smart00937
637913000429	RF-1 domain; Region: RF-1; pfam00472
637913000430	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
637913000431	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
637913000432	dimer interface [polypeptide binding]; other site
637913000433	putative functional site; other site
637913000434	putative MPT binding site; other site
637913000435	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
637913000436	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
637913000437	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
637913000438	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
637913000439	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
637913000440	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
637913000441	intersubunit interface [polypeptide binding]; other site
637913000442	active site
637913000443	zinc binding site [ion binding]; other site
637913000444	Na+ binding site [ion binding]; other site
637913000445	elongation factor P; Validated; Region: PRK00529
637913000446	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
637913000447	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
637913000448	RNA binding site [nucleotide binding]; other site
637913000449	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
637913000450	RNA binding site [nucleotide binding]; other site
637913000451	pseudaminic acid synthase; Region: PseI; TIGR03586
637913000452	NeuB family; Region: NeuB; pfam03102
637913000453	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
637913000454	NeuB binding interface [polypeptide binding]; other site
637913000455	putative substrate binding site [chemical binding]; other site
637913000456	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637913000457	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637913000458	Walker A/P-loop; other site
637913000459	ATP binding site [chemical binding]; other site
637913000460	Q-loop/lid; other site
637913000461	ABC transporter signature motif; other site
637913000462	Walker B; other site
637913000463	D-loop; other site
637913000464	H-loop/switch region; other site
637913000465	apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291
637913000466	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
637913000467	active site
637913000468	catalytic triad [active]
637913000469	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
637913000470	Colicin V production protein; Region: Colicin_V; pfam02674
637913000471	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
637913000472	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
637913000473	dimer interface [polypeptide binding]; other site
637913000474	putative anticodon binding site; other site
637913000475	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
637913000476	motif 1; other site
637913000477	active site
637913000478	motif 2; other site
637913000479	motif 3; other site
637913000480	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
637913000481	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
637913000482	dimer interface [polypeptide binding]; other site
637913000483	active site
637913000484	glycine-pyridoxal phosphate binding site [chemical binding]; other site
637913000485	folate binding site [chemical binding]; other site
637913000486	Domain of unknown function (DUF1882); Region: DUF1882; pfam08966
637913000487	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
637913000488	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913000489	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913000490	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
637913000491	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
637913000492	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
637913000493	putative active site [active]
637913000494	catalytic site [active]
637913000495	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
637913000496	PLD-like domain; Region: PLDc_2; pfam13091
637913000497	putative active site [active]
637913000498	catalytic site [active]
637913000499	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
637913000500	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
637913000501	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637913000502	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
637913000503	L-aspartate oxidase; Provisional; Region: PRK06175
637913000504	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
637913000505	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553
637913000506	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
637913000507	Iron-sulfur protein interface; other site
637913000508	proximal heme binding site [chemical binding]; other site
637913000509	distal heme binding site [chemical binding]; other site
637913000510	dimer interface [polypeptide binding]; other site
637913000511	triosephosphate isomerase; Provisional; Region: PRK14567
637913000512	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
637913000513	substrate binding site [chemical binding]; other site
637913000514	dimer interface [polypeptide binding]; other site
637913000515	catalytic triad [active]
637913000516	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415
637913000517	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
637913000518	NAD binding site [chemical binding]; other site
637913000519	homotetramer interface [polypeptide binding]; other site
637913000520	homodimer interface [polypeptide binding]; other site
637913000521	substrate binding site [chemical binding]; other site
637913000522	active site
637913000523	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
637913000524	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
637913000525	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
637913000526	trimer interface [polypeptide binding]; other site
637913000527	active site
637913000528	UDP-GlcNAc binding site [chemical binding]; other site
637913000529	lipid binding site [chemical binding]; lipid-binding site
637913000530	S-adenosylmethionine synthetase; Validated; Region: PRK05250
637913000531	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
637913000532	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
637913000533	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
637913000534	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
637913000535	active site
637913000536	multimer interface [polypeptide binding]; other site
637913000537	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
637913000538	fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182
637913000539	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
637913000540	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
637913000541	dimer interface [polypeptide binding]; other site
637913000542	active site
637913000543	CoA binding pocket [chemical binding]; other site
637913000544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913000545	Walker A/P-loop; other site
637913000546	ATP binding site [chemical binding]; other site
637913000547	AAA ATPase domain; Region: AAA_15; pfam13175
637913000548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
637913000549	Walker B; other site
637913000550	D-loop; other site
637913000551	H-loop/switch region; other site
637913000552	antiporter inner membrane protein; Provisional; Region: PRK11670
637913000553	Domain of unknown function DUF59; Region: DUF59; pfam01883
637913000554	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
637913000555	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913000556	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637913000557	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913000558	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637913000559	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913000560	heat shock protein 90; Provisional; Region: PRK05218
637913000561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637913000562	ATP binding site [chemical binding]; other site
637913000563	Mg2+ binding site [ion binding]; other site
637913000564	G-X-G motif; other site
637913000565	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913000566	Sel1-like repeats; Region: SEL1; smart00671
637913000567	Sel1-like repeats; Region: SEL1; smart00671
637913000568	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913000569	TPR motif; other site
637913000570	binding surface
637913000571	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
637913000572	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
637913000573	metal binding site [ion binding]; metal-binding site
637913000574	dimer interface [polypeptide binding]; other site
637913000575	glucose-inhibited division protein A; Region: gidA; TIGR00136
637913000576	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637913000577	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
637913000578	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
637913000579	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
637913000580	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
637913000581	transmembrane helices; other site
637913000582	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
637913000583	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
637913000584	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
637913000585	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
637913000586	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
637913000587	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
637913000588	substrate binding site [chemical binding]; other site
637913000589	Helix-turn-helix domain; Region: HTH_28; pfam13518
637913000590	cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403
637913000591	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
637913000592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637913000593	catalytic residue [active]
637913000594	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
637913000595	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
637913000596	trimerization site [polypeptide binding]; other site
637913000597	active site
637913000598	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
637913000599	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
637913000600	DNA repair protein RadA; Region: sms; TIGR00416
637913000601	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
637913000602	Walker A motif/ATP binding site; other site
637913000603	ATP binding site [chemical binding]; other site
637913000604	Walker B motif; other site
637913000605	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
637913000606	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
637913000607	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
637913000608	SelR domain; Region: SelR; pfam01641
637913000609	Predicted permeases [General function prediction only]; Region: COG0730
637913000610	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000611	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
637913000612	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
637913000613	Sulfate transporter family; Region: Sulfate_transp; pfam00916
637913000614	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000615	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
637913000616	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
637913000617	Ligand binding site; other site
637913000618	oligomer interface; other site
637913000619	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
637913000620	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637913000621	hypothetical protein; Provisional; Region: PRK04081
637913000622	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
637913000623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
637913000624	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913000625	Sel1-like repeats; Region: SEL1; smart00671
637913000626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913000627	binding surface
637913000628	TPR motif; other site
637913000629	Sel1-like repeats; Region: SEL1; smart00671
637913000630	Sel1-like repeats; Region: SEL1; smart00671
637913000631	Cytochrome c; Region: Cytochrom_C; cl11414
637913000632	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
637913000633	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
637913000634	domain interfaces; other site
637913000635	active site
637913000636	prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409
637913000637	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
637913000638	dimer interface [polypeptide binding]; other site
637913000639	motif 1; other site
637913000640	active site
637913000641	motif 2; other site
637913000642	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
637913000643	putative deacylase active site [active]
637913000644	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
637913000645	active site
637913000646	motif 3; other site
637913000647	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
637913000648	anticodon binding site; other site
637913000649	glutamyl-tRNA reductase; Region: hemA; TIGR01035
637913000650	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
637913000651	tRNA; other site
637913000652	putative tRNA binding site [nucleotide binding]; other site
637913000653	putative NADP binding site [chemical binding]; other site
637913000654	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
637913000655	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
637913000656	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
637913000657	substrate binding pocket [chemical binding]; other site
637913000658	chain length determination region; other site
637913000659	substrate-Mg2+ binding site; other site
637913000660	catalytic residues [active]
637913000661	aspartate-rich region 1; other site
637913000662	active site lid residues [active]
637913000663	aspartate-rich region 2; other site
637913000664	Domain of unknown function (DUF2018); Region: DUF2018; pfam09442
637913000665	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
637913000666	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
637913000667	dimerization interface [polypeptide binding]; other site
637913000668	DPS ferroxidase diiron center [ion binding]; other site
637913000669	ion pore; other site
637913000670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637913000671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637913000672	dimer interface [polypeptide binding]; other site
637913000673	phosphorylation site [posttranslational modification]
637913000674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637913000675	ATP binding site [chemical binding]; other site
637913000676	Mg2+ binding site [ion binding]; other site
637913000677	G-X-G motif; other site
637913000678	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
637913000679	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
637913000680	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
637913000681	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637913000682	ATP binding site [chemical binding]; other site
637913000683	Mg++ binding site [ion binding]; other site
637913000684	motif III; other site
637913000685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637913000686	nucleotide binding region [chemical binding]; other site
637913000687	ATP-binding site [chemical binding]; other site
637913000688	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
637913000689	SPFH domain / Band 7 family; Region: Band_7; pfam01145
637913000690	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
637913000691	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
637913000692	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
637913000693	Walker A/P-loop; other site
637913000694	ATP binding site [chemical binding]; other site
637913000695	Q-loop/lid; other site
637913000696	ABC transporter signature motif; other site
637913000697	Walker B; other site
637913000698	D-loop; other site
637913000699	H-loop/switch region; other site
637913000700	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
637913000701	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
637913000702	Walker A/P-loop; other site
637913000703	ATP binding site [chemical binding]; other site
637913000704	Q-loop/lid; other site
637913000705	ABC transporter signature motif; other site
637913000706	Walker B; other site
637913000707	D-loop; other site
637913000708	H-loop/switch region; other site
637913000709	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
637913000710	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
637913000711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913000712	dimer interface [polypeptide binding]; other site
637913000713	conserved gate region; other site
637913000714	putative PBP binding loops; other site
637913000715	ABC-ATPase subunit interface; other site
637913000716	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000717	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000718	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
637913000719	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
637913000720	GDP-binding site [chemical binding]; other site
637913000721	ACT binding site; other site
637913000722	IMP binding site; other site
637913000723	Flagellar FliJ protein; Region: FliJ; pfam02050
637913000724	Uncharacterized conserved protein [Function unknown]; Region: COG3334
637913000725	RIP metalloprotease RseP; Region: TIGR00054
637913000726	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
637913000727	active site
637913000728	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
637913000729	protein binding site [polypeptide binding]; other site
637913000730	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
637913000731	putative substrate binding region [chemical binding]; other site
637913000732	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
637913000733	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
637913000734	generic binding surface II; other site
637913000735	generic binding surface I; other site
637913000736	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913000737	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913000738	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
637913000739	Clp amino terminal domain; Region: Clp_N; pfam02861
637913000740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913000741	Walker A motif; other site
637913000742	ATP binding site [chemical binding]; other site
637913000743	Walker B motif; other site
637913000744	arginine finger; other site
637913000745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913000746	Walker A motif; other site
637913000747	ATP binding site [chemical binding]; other site
637913000748	Walker B motif; other site
637913000749	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
637913000750	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
637913000751	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
637913000752	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
637913000753	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637913000754	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637913000755	active site
637913000756	chlorohydrolase; Provisional; Region: PRK08418
637913000757	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
637913000758	active site
637913000759	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
637913000760	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339
637913000761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913000762	FeS/SAM binding site; other site
637913000763	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
637913000764	putative acyl-acceptor binding pocket; other site
637913000765	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
637913000766	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
637913000767	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
637913000768	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
637913000769	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913000770	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
637913000771	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
637913000772	putative active site [active]
637913000773	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
637913000774	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
637913000775	putative acyl-acceptor binding pocket; other site
637913000776	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
637913000777	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
637913000778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400
637913000779	TrkA-C domain; Region: TrkA_C; pfam02080
637913000780	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
637913000781	active site
637913000782	dimer interface [polypeptide binding]; other site
637913000783	metal binding site [ion binding]; metal-binding site
637913000784	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
637913000785	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637913000786	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
637913000787	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
637913000788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913000789	FeS/SAM binding site; other site
637913000790	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
637913000791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913000792	Walker A motif; other site
637913000793	ATP binding site [chemical binding]; other site
637913000794	Walker B motif; other site
637913000795	arginine finger; other site
637913000796	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
637913000797	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913000798	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913000799	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
637913000800	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913000801	Autotransporter beta-domain; Region: Autotransporter; pfam03797
637913000802	diaminopimelate decarboxylase; Region: lysA; TIGR01048
637913000803	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
637913000804	active site
637913000805	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637913000806	substrate binding site [chemical binding]; other site
637913000807	catalytic residues [active]
637913000808	dimer interface [polypeptide binding]; other site
637913000809	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
637913000810	Uncharacterized conserved protein [Function unknown]; Region: COG4866
637913000811	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
637913000812	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
637913000813	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
637913000814	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
637913000815	substrate-cofactor binding pocket; other site
637913000816	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913000817	catalytic residue [active]
637913000818	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
637913000819	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
637913000820	multimer interface [polypeptide binding]; other site
637913000821	active site
637913000822	catalytic triad [active]
637913000823	dimer interface [polypeptide binding]; other site
637913000824	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412
637913000825	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637913000826	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
637913000827	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
637913000828	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
637913000829	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
637913000830	peptide binding site [polypeptide binding]; other site
637913000831	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
637913000832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913000833	dimer interface [polypeptide binding]; other site
637913000834	conserved gate region; other site
637913000835	putative PBP binding loops; other site
637913000836	ABC-ATPase subunit interface; other site
637913000837	dipeptide transporter; Provisional; Region: PRK10913
637913000838	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
637913000839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913000840	dimer interface [polypeptide binding]; other site
637913000841	conserved gate region; other site
637913000842	putative PBP binding loops; other site
637913000843	ABC-ATPase subunit interface; other site
637913000844	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
637913000845	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
637913000846	Walker A/P-loop; other site
637913000847	ATP binding site [chemical binding]; other site
637913000848	Q-loop/lid; other site
637913000849	ABC transporter signature motif; other site
637913000850	Walker B; other site
637913000851	D-loop; other site
637913000852	H-loop/switch region; other site
637913000853	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
637913000854	GTPase CgtA; Reviewed; Region: obgE; PRK12299
637913000855	GTP1/OBG; Region: GTP1_OBG; pfam01018
637913000856	Obg GTPase; Region: Obg; cd01898
637913000857	G1 box; other site
637913000858	GTP/Mg2+ binding site [chemical binding]; other site
637913000859	Switch I region; other site
637913000860	G2 box; other site
637913000861	G3 box; other site
637913000862	Switch II region; other site
637913000863	G4 box; other site
637913000864	G5 box; other site
637913000865	Alginate lyase; Region: Alginate_lyase; pfam05426
637913000866	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
637913000867	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637913000868	inhibitor-cofactor binding pocket; inhibition site
637913000869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913000870	catalytic residue [active]
637913000871	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
637913000872	Predicted amidohydrolase [General function prediction only]; Region: COG0388
637913000873	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
637913000874	active site
637913000875	catalytic triad [active]
637913000876	dimer interface [polypeptide binding]; other site
637913000877	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
637913000878	active site
637913000879	catalytic site [active]
637913000880	Zn binding site [ion binding]; other site
637913000881	tetramer interface [polypeptide binding]; other site
637913000882	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
637913000883	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913000884	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913000885	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
637913000886	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
637913000887	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
637913000888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913000889	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637913000890	putative substrate translocation pore; other site
637913000891	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
637913000892	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
637913000893	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
637913000894	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
637913000895	arginyl-tRNA synthetase; Region: argS; TIGR00456
637913000896	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
637913000897	active site
637913000898	HIGH motif; other site
637913000899	KMSK motif region; other site
637913000900	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
637913000901	tRNA binding surface [nucleotide binding]; other site
637913000902	anticodon binding site; other site
637913000903	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
637913000904	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
637913000905	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
637913000906	catalytic site [active]
637913000907	G-X2-G-X-G-K; other site
637913000908	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
637913000909	nuclease NucT; Provisional; Region: PRK13912
637913000910	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
637913000911	putative active site [active]
637913000912	catalytic site [active]
637913000913	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913000914	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
637913000915	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
637913000916	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
637913000917	ligand binding site; other site
637913000918	tetramer interface; other site
637913000919	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
637913000920	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
637913000921	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637913000922	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
637913000923	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
637913000924	NAD synthetase; Provisional; Region: PRK13980
637913000925	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
637913000926	homodimer interface [polypeptide binding]; other site
637913000927	NAD binding pocket [chemical binding]; other site
637913000928	ATP binding pocket [chemical binding]; other site
637913000929	Mg binding site [ion binding]; other site
637913000930	active-site loop [active]
637913000931	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
637913000932	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
637913000933	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
637913000934	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
637913000935	Switch I; other site
637913000936	Switch II; other site
637913000937	cell division topological specificity factor MinE; Region: minE; TIGR01215
637913000938	DNA protecting protein DprA; Region: dprA; TIGR00732
637913000939	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
637913000940	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
637913000941	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913000942	Sel1-like repeats; Region: SEL1; smart00671
637913000943	Sel1-like repeats; Region: SEL1; smart00671
637913000944	Sel1-like repeats; Region: SEL1; smart00671
637913000945	Sel1-like repeats; Region: SEL1; smart00671
637913000946	Sel1-like repeats; Region: SEL1; smart00671
637913000947	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
637913000948	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637913000949	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637913000950	active site
637913000951	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
637913000952	DHH family; Region: DHH; pfam01368
637913000953	DHHA1 domain; Region: DHHA1; pfam02272
637913000954	CTP synthetase; Validated; Region: pyrG; PRK05380
637913000955	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
637913000956	Catalytic site [active]
637913000957	active site
637913000958	UTP binding site [chemical binding]; other site
637913000959	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
637913000960	active site
637913000961	putative oxyanion hole; other site
637913000962	catalytic triad [active]
637913000963	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
637913000964	active site
637913000965	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
637913000966	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
637913000967	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
637913000968	flagellar motor switch protein FliG; Region: fliG; TIGR00207
637913000969	FliG C-terminal domain; Region: FliG_C; pfam01706
637913000970	flagellar assembly protein H; Validated; Region: fliH; PRK06669
637913000971	Flagellar assembly protein FliH; Region: FliH; pfam02108
637913000972	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
637913000973	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
637913000974	TPP-binding site; other site
637913000975	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
637913000976	PYR/PP interface [polypeptide binding]; other site
637913000977	dimer interface [polypeptide binding]; other site
637913000978	TPP binding site [chemical binding]; other site
637913000979	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637913000980	GTP-binding protein LepA; Provisional; Region: PRK05433
637913000981	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
637913000982	G1 box; other site
637913000983	putative GEF interaction site [polypeptide binding]; other site
637913000984	GTP/Mg2+ binding site [chemical binding]; other site
637913000985	Switch I region; other site
637913000986	G2 box; other site
637913000987	G3 box; other site
637913000988	Switch II region; other site
637913000989	G4 box; other site
637913000990	G5 box; other site
637913000991	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
637913000992	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
637913000993	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
637913000994	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
637913000995	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
637913000996	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
637913000997	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
637913000998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913000999	putative substrate translocation pore; other site
637913001000	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
637913001001	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
637913001002	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
637913001003	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
637913001004	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
637913001005	transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232
637913001006	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
637913001007	TPP-binding site [chemical binding]; other site
637913001008	dimer interface [polypeptide binding]; other site
637913001009	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
637913001010	PYR/PP interface [polypeptide binding]; other site
637913001011	dimer interface [polypeptide binding]; other site
637913001012	TPP binding site [chemical binding]; other site
637913001013	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637913001014	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
637913001015	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
637913001016	active site
637913001017	Riboflavin kinase; Region: Flavokinase; smart00904
637913001018	hemolysin TlyA family protein; Region: tly; TIGR00478
637913001019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913001020	S-adenosylmethionine binding site [chemical binding]; other site
637913001021	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
637913001022	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
637913001023	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
637913001024	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913001025	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
637913001026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637913001027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913001028	Walker A/P-loop; other site
637913001029	ATP binding site [chemical binding]; other site
637913001030	Q-loop/lid; other site
637913001031	ABC transporter signature motif; other site
637913001032	Walker B; other site
637913001033	D-loop; other site
637913001034	H-loop/switch region; other site
637913001035	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
637913001036	Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787
637913001037	Restriction endonuclease; Region: Mrr_cat; pfam04471
637913001038	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
637913001039	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
637913001040	active site
637913001041	Zn binding site [ion binding]; other site
637913001042	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
637913001043	metal-binding site [ion binding]
637913001044	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
637913001045	metal-binding site [ion binding]
637913001046	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
637913001047	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
637913001048	Soluble P-type ATPase [General function prediction only]; Region: COG4087
637913001049	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
637913001050	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
637913001051	FtsH Extracellular; Region: FtsH_ext; pfam06480
637913001052	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
637913001053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001054	Walker A motif; other site
637913001055	ATP binding site [chemical binding]; other site
637913001056	Walker B motif; other site
637913001057	arginine finger; other site
637913001058	Peptidase family M41; Region: Peptidase_M41; pfam01434
637913001059	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
637913001060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637913001061	S-adenosylmethionine binding site [chemical binding]; other site
637913001062	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637913001063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913001064	active site
637913001065	phosphorylation site [posttranslational modification]
637913001066	intermolecular recognition site; other site
637913001067	dimerization interface [polypeptide binding]; other site
637913001068	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001069	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
637913001070	16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138
637913001071	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
637913001072	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
637913001073	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
637913001074	sec-independent translocase; Provisional; Region: PRK04098
637913001075	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
637913001076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001077	Walker A motif; other site
637913001078	ATP binding site [chemical binding]; other site
637913001079	Walker B motif; other site
637913001080	arginine finger; other site
637913001081	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
637913001082	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
637913001083	oligomerization interface [polypeptide binding]; other site
637913001084	active site
637913001085	metal binding site [ion binding]; metal-binding site
637913001086	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001087	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001088	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637913001089	septum formation inhibitor; Reviewed; Region: minC; PRK00556
637913001090	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
637913001091	UDP-3-0-acyl N-acetylglucosamine deacetylase; Region: lpxC; TIGR00325
637913001092	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
637913001093	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
637913001094	homoserine kinase; Region: thrB; TIGR00191
637913001095	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
637913001096	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
637913001097	putative RNA binding cleft [nucleotide binding]; other site
637913001098	translation initiation factor IF-2; Region: IF-2; TIGR00487
637913001099	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
637913001100	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
637913001101	G1 box; other site
637913001102	putative GEF interaction site [polypeptide binding]; other site
637913001103	GTP/Mg2+ binding site [chemical binding]; other site
637913001104	Switch I region; other site
637913001105	G2 box; other site
637913001106	G3 box; other site
637913001107	Switch II region; other site
637913001108	G4 box; other site
637913001109	G5 box; other site
637913001110	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
637913001111	Translation-initiation factor 2; Region: IF-2; pfam11987
637913001112	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
637913001113	Ribosome-binding factor A; Region: RBFA; cl00542
637913001114	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
637913001115	Sm and related proteins; Region: Sm_like; cl00259
637913001116	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
637913001117	putative oligomer interface [polypeptide binding]; other site
637913001118	putative RNA binding site [nucleotide binding]; other site
637913001119	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
637913001120	putative active site [active]
637913001121	putative metal binding site [ion binding]; other site
637913001122	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637913001123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637913001124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913001125	active site
637913001126	intermolecular recognition site; other site
637913001127	dimerization interface [polypeptide binding]; other site
637913001128	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637913001129	DNA binding site [nucleotide binding]
637913001130	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
637913001131	flagellar biosynthesis protein FlhA; Region: FlhA; TIGR01398
637913001132	FHIPEP family; Region: FHIPEP; pfam00771
637913001133	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
637913001134	16S/18S rRNA binding site [nucleotide binding]; other site
637913001135	S13e-L30e interaction site [polypeptide binding]; other site
637913001136	25S rRNA binding site [nucleotide binding]; other site
637913001137	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
637913001138	O-Antigen ligase; Region: Wzy_C; pfam04932
637913001139	Dehydroquinase class II; Region: DHquinase_II; pfam01220
637913001140	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
637913001141	trimer interface [polypeptide binding]; other site
637913001142	active site
637913001143	dimer interface [polypeptide binding]; other site
637913001144	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
637913001145	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
637913001146	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
637913001147	active site
637913001148	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
637913001149	catalytic center binding site [active]
637913001150	ATP binding site [chemical binding]; other site
637913001151	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
637913001152	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
637913001153	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
637913001154	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
637913001155	P-loop; other site
637913001156	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
637913001157	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
637913001158	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637913001159	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637913001160	DNA binding residues [nucleotide binding]
637913001161	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
637913001162	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
637913001163	flagellar motor switch protein FliY; Validated; Region: PRK08432
637913001164	flagellar motor switch protein FliN; Region: fliN; TIGR02480
637913001165	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
637913001166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
637913001167	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
637913001168	metal binding site 2 [ion binding]; metal-binding site
637913001169	putative DNA binding helix; other site
637913001170	metal binding site 1 [ion binding]; metal-binding site
637913001171	dimer interface [polypeptide binding]; other site
637913001172	structural Zn2+ binding site [ion binding]; other site
637913001173	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
637913001174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001175	Walker A motif; other site
637913001176	ATP binding site [chemical binding]; other site
637913001177	Walker B motif; other site
637913001178	arginine finger; other site
637913001179	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
637913001180	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
637913001181	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
637913001182	DNA binding residues [nucleotide binding]
637913001183	putative dimer interface [polypeptide binding]; other site
637913001184	chaperone protein DnaJ; Provisional; Region: PRK14299
637913001185	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
637913001186	HSP70 interaction site [polypeptide binding]; other site
637913001187	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
637913001188	substrate binding site [polypeptide binding]; other site
637913001189	dimer interface [polypeptide binding]; other site
637913001190	5'-3' exonuclease; Provisional; Region: PRK14976
637913001191	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
637913001192	putative active site [active]
637913001193	Helix-hairpin-helix class 2 (Pol1 family) motifs; Region: HhH2; smart00279
637913001194	DNA binding site [nucleotide binding]
637913001195	metal binding site [ion binding]; metal-binding site
637913001196	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637913001197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913001198	active site
637913001199	dimerization interface [polypeptide binding]; other site
637913001200	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
637913001201	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
637913001202	substrate binding site; other site
637913001203	dimer interface; other site
637913001204	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
637913001205	homotrimer interaction site [polypeptide binding]; other site
637913001206	zinc binding site [ion binding]; other site
637913001207	CDP-binding sites; other site
637913001208	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
637913001209	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
637913001210	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
637913001211	protein binding site [polypeptide binding]; other site
637913001212	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
637913001213	protein binding site [polypeptide binding]; other site
637913001214	S-methylmethionine transporter; Provisional; Region: PRK11387
637913001215	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
637913001216	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
637913001217	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
637913001218	putative NAD(P) binding site [chemical binding]; other site
637913001219	active site
637913001220	dihydrodipicolinate synthase; Region: dapA; TIGR00674
637913001221	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
637913001222	dimer interface [polypeptide binding]; other site
637913001223	active site
637913001224	catalytic residue [active]
637913001225	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637913001226	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637913001227	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637913001228	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
637913001229	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
637913001230	quinone interaction residues [chemical binding]; other site
637913001231	active site
637913001232	catalytic residues [active]
637913001233	FMN binding site [chemical binding]; other site
637913001234	substrate binding site [chemical binding]; other site
637913001235	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
637913001236	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
637913001237	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
637913001238	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
637913001239	putative domain interface [polypeptide binding]; other site
637913001240	putative active site [active]
637913001241	catalytic site [active]
637913001242	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
637913001243	putative active site [active]
637913001244	putative domain interface [polypeptide binding]; other site
637913001245	catalytic site [active]
637913001246	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
637913001247	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
637913001248	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
637913001249	Methyltransferase domain; Region: Methyltransf_26; pfam13659
637913001250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
637913001251	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
637913001252	putative metal binding site [ion binding]; other site
637913001253	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
637913001254	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
637913001255	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
637913001256	active site
637913001257	Zn binding site [ion binding]; other site
637913001258	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
637913001259	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
637913001260	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001261	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
637913001262	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
637913001263	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
637913001264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913001265	dimer interface [polypeptide binding]; other site
637913001266	conserved gate region; other site
637913001267	putative PBP binding loops; other site
637913001268	ABC-ATPase subunit interface; other site
637913001269	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
637913001270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913001271	Walker A/P-loop; other site
637913001272	ATP binding site [chemical binding]; other site
637913001273	Q-loop/lid; other site
637913001274	ABC transporter signature motif; other site
637913001275	Walker B; other site
637913001276	D-loop; other site
637913001277	H-loop/switch region; other site
637913001278	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
637913001279	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
637913001280	active site
637913001281	HIGH motif; other site
637913001282	nucleotide binding site [chemical binding]; other site
637913001283	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
637913001284	active site
637913001285	KMSKS motif; other site
637913001286	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001287	Helix-turn-helix domain; Region: HTH_17; pfam12728
637913001288	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
637913001289	Methyltransferase domain; Region: Methyltransf_26; pfam13659
637913001290	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
637913001291	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913001292	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637913001293	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
637913001294	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
637913001295	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
637913001296	G1 box; other site
637913001297	putative GEF interaction site [polypeptide binding]; other site
637913001298	GTP/Mg2+ binding site [chemical binding]; other site
637913001299	Switch I region; other site
637913001300	G2 box; other site
637913001301	G3 box; other site
637913001302	Switch II region; other site
637913001303	G4 box; other site
637913001304	G5 box; other site
637913001305	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
637913001306	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
637913001307	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
637913001308	Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436
637913001309	GIY-YIG motif/motif A; other site
637913001310	DNA binding site [nucleotide binding]
637913001311	active site
637913001312	catalytic site [active]
637913001313	metal binding site [ion binding]; metal-binding site
637913001314	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
637913001315	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
637913001316	substrate interaction site [chemical binding]; other site
637913001317	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
637913001318	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
637913001319	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
637913001320	putative heme binding pocket [chemical binding]; other site
637913001321	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913001322	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913001323	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
637913001324	Cation transport protein; Region: TrkH; cl17365
637913001325	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
637913001326	TrkA-N domain; Region: TrkA_N; pfam02254
637913001327	TrkA-C domain; Region: TrkA_C; pfam02080
637913001328	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
637913001329	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
637913001330	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
637913001331	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
637913001332	Mg++ binding site [ion binding]; other site
637913001333	putative catalytic motif [active]
637913001334	putative substrate binding site [chemical binding]; other site
637913001335	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
637913001336	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637913001337	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637913001338	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637913001339	active site
637913001340	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
637913001341	Na2 binding site [ion binding]; other site
637913001342	putative substrate binding site 1 [chemical binding]; other site
637913001343	Na binding site 1 [ion binding]; other site
637913001344	putative substrate binding site 2 [chemical binding]; other site
637913001345	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
637913001346	Na2 binding site [ion binding]; other site
637913001347	putative substrate binding site 1 [chemical binding]; other site
637913001348	Na binding site 1 [ion binding]; other site
637913001349	putative substrate binding site 2 [chemical binding]; other site
637913001350	DNA polymerase III, beta subunit; Region: dnan; TIGR00663
637913001351	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
637913001352	putative DNA binding surface [nucleotide binding]; other site
637913001353	dimer interface [polypeptide binding]; other site
637913001354	beta-clamp/translesion DNA polymerase binding surface; other site
637913001355	beta-clamp/clamp loader binding surface; other site
637913001356	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
637913001357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637913001358	Mg2+ binding site [ion binding]; other site
637913001359	G-X-G motif; other site
637913001360	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
637913001361	anchoring element; other site
637913001362	dimer interface [polypeptide binding]; other site
637913001363	ATP binding site [chemical binding]; other site
637913001364	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
637913001365	active site
637913001366	putative metal-binding site [ion binding]; other site
637913001367	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
637913001368	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637913001369	Peptidase family M23; Region: Peptidase_M23; pfam01551
637913001370	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
637913001371	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
637913001372	dimer interface [polypeptide binding]; other site
637913001373	ADP-ribose binding site [chemical binding]; other site
637913001374	active site
637913001375	nudix motif; other site
637913001376	metal binding site [ion binding]; metal-binding site
637913001377	FAD binding domain; Region: FAD_binding_4; pfam01565
637913001378	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
637913001379	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
637913001380	dihydrodipicolinate reductase; Region: dapB; TIGR00036
637913001381	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
637913001382	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
637913001383	glutamine synthetase, type I; Region: GlnA; TIGR00653
637913001384	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
637913001385	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
637913001386	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913001387	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913001388	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
637913001389	Uncharacterized conserved protein [Function unknown]; Region: COG3586
637913001390	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
637913001391	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
637913001392	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
637913001393	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
637913001394	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
637913001395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001396	Walker A motif; other site
637913001397	ATP binding site [chemical binding]; other site
637913001398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001399	Walker B motif; other site
637913001400	arginine finger; other site
637913001401	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
637913001402	GTPase [General function prediction only]; Region: Era; COG1159
637913001403	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
637913001404	G1 box; other site
637913001405	GTP/Mg2+ binding site [chemical binding]; other site
637913001406	Switch I region; other site
637913001407	G2 box; other site
637913001408	Switch II region; other site
637913001409	G3 box; other site
637913001410	G4 box; other site
637913001411	G5 box; other site
637913001412	KH domain; Region: KH_2; pfam07650
637913001413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
637913001414	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
637913001415	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
637913001416	Walker A motif; other site
637913001417	ATP binding site [chemical binding]; other site
637913001418	Walker B motif; other site
637913001419	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
637913001420	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
637913001421	ATP binding site [chemical binding]; other site
637913001422	Walker A motif; other site
637913001423	hexamer interface [polypeptide binding]; other site
637913001424	Walker B motif; other site
637913001425	CagZ; Region: CagZ; pfam09053
637913001426	DC-EC Repeat; Region: CagY_M; pfam07337
637913001427	DC-EC Repeat; Region: CagY_M; pfam07337
637913001428	DC-EC Repeat; Region: CagY_M; pfam07337
637913001429	DC-EC Repeat; Region: CagY_M; pfam07337
637913001430	DC-EC Repeat; Region: CagY_M; pfam07337
637913001431	DC-EC Repeat; Region: CagY_M; pfam07337
637913001432	DC-EC Repeat; Region: CagY_M; pfam07337
637913001433	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
637913001434	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
637913001435	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
637913001436	VirB7 interaction site; other site
637913001437	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
637913001438	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
637913001439	prolyl-tRNA synthetase; Provisional; Region: PRK08661
637913001440	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
637913001441	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
637913001442	CagA exotoxin; Region: CagA; pfam03507
637913001443	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
637913001444	transcription termination factor Rho; Provisional; Region: rho; PRK09376
637913001445	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
637913001446	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
637913001447	RNA binding site [nucleotide binding]; other site
637913001448	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
637913001449	multimer interface [polypeptide binding]; other site
637913001450	Walker A motif; other site
637913001451	ATP binding site [chemical binding]; other site
637913001452	Walker B motif; other site
637913001453	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
637913001454	Predicted methyltransferases [General function prediction only]; Region: COG0313
637913001455	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
637913001456	putative SAM binding site [chemical binding]; other site
637913001457	putative homodimer interface [polypeptide binding]; other site
637913001458	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
637913001459	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
637913001460	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
637913001461	acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Region: accA; TIGR00513
637913001462	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
637913001463	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439
637913001464	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
637913001465	dimer interface [polypeptide binding]; other site
637913001466	active site
637913001467	acyl carrier protein; Provisional; Region: acpP; PRK00982
637913001468	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
637913001469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637913001470	NAD(P) binding site [chemical binding]; other site
637913001471	active site
637913001472	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
637913001473	Phosphatidylinositol-specific phospholipase C, Y domain; Region: PI-PLC-Y; cl14781
637913001474	Predicted membrane protein [Function unknown]; Region: COG3059
637913001475	diaminopimelate epimerase; Region: DapF; TIGR00652
637913001476	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
637913001477	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
637913001478	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
637913001479	Domain of unknown function DUF20; Region: UPF0118; pfam01594
637913001480	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
637913001481	GTP-binding protein YchF; Reviewed; Region: PRK09601
637913001482	YchF GTPase; Region: YchF; cd01900
637913001483	G1 box; other site
637913001484	GTP/Mg2+ binding site [chemical binding]; other site
637913001485	Switch I region; other site
637913001486	G2 box; other site
637913001487	Switch II region; other site
637913001488	G3 box; other site
637913001489	G4 box; other site
637913001490	G5 box; other site
637913001491	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
637913001492	multifunctional aminopeptidase A; Provisional; Region: PRK00913
637913001493	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
637913001494	interface (dimer of trimers) [polypeptide binding]; other site
637913001495	Substrate-binding/catalytic site; other site
637913001496	Zn-binding sites [ion binding]; other site
637913001497	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
637913001498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637913001499	active site
637913001500	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
637913001501	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
637913001502	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
637913001503	Peptidase family M50; Region: Peptidase_M50; pfam02163
637913001504	active site
637913001505	putative substrate binding region [chemical binding]; other site
637913001506	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
637913001507	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637913001508	Catalytic site [active]
637913001509	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637913001510	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191
637913001511	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
637913001512	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
637913001513	homodimer interface [polypeptide binding]; other site
637913001514	NADP binding site [chemical binding]; other site
637913001515	substrate binding site [chemical binding]; other site
637913001516	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
637913001517	Sulfatase; Region: Sulfatase; pfam00884
637913001518	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
637913001519	BNR repeat-like domain; Region: BNR_2; pfam13088
637913001520	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
637913001521	active site
637913001522	substrate binding pocket [chemical binding]; other site
637913001523	dimer interface [polypeptide binding]; other site
637913001524	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
637913001525	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
637913001526	flagellar motor switch protein; Validated; Region: PRK08433
637913001527	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
637913001528	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
637913001529	minor groove reading motif; other site
637913001530	helix-hairpin-helix signature motif; other site
637913001531	substrate binding pocket [chemical binding]; other site
637913001532	active site
637913001533	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
637913001534	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
637913001535	Protein of unknown function; Region: DUF3971; pfam13116
637913001536	AsmA-like C-terminal region; Region: AsmA_1; pfam13109
637913001537	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
637913001538	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
637913001539	dimerization interface [polypeptide binding]; other site
637913001540	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
637913001541	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
637913001542	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
637913001543	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
637913001544	dimer interface [polypeptide binding]; other site
637913001545	PYR/PP interface [polypeptide binding]; other site
637913001546	TPP binding site [chemical binding]; other site
637913001547	substrate binding site [chemical binding]; other site
637913001548	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
637913001549	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
637913001550	TPP-binding site [chemical binding]; other site
637913001551	2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441
637913001552	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
637913001553	Restriction endonuclease [Defense mechanisms]; Region: COG3587
637913001554	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913001555	ATP binding site [chemical binding]; other site
637913001556	putative Mg++ binding site [ion binding]; other site
637913001557	DNA double-strand break repair and V(D)J recombination protein XRCC4; Region: XRCC4; pfam06632
637913001558	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
637913001559	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913001560	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913001561	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
637913001562	tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303
637913001563	Transglycosylase; Region: Transgly; pfam00912
637913001564	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
637913001565	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
637913001566	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
637913001567	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
637913001568	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637913001569	catalytic residue [active]
637913001570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637913001571	dimer interface [polypeptide binding]; other site
637913001572	putative CheW interface [polypeptide binding]; other site
637913001573	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
637913001574	flagellin A; Reviewed; Region: PRK12584
637913001575	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637913001576	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637913001577	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637913001578	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
637913001579	3-methyladenine DNA glycosylase; Provisional; Region: PRK13913
637913001580	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
637913001581	minor groove reading motif; other site
637913001582	helix-hairpin-helix signature motif; other site
637913001583	active site
637913001584	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
637913001585	substrate binding site [chemical binding]; other site
637913001586	active site
637913001587	Outer membrane efflux protein; Region: OEP; pfam02321
637913001588	Outer membrane efflux protein; Region: OEP; pfam02321
637913001589	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637913001590	HlyD family secretion protein; Region: HlyD_3; pfam13437
637913001591	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
637913001592	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001593	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
637913001594	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913001595	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913001596	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913001597	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913001598	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
637913001599	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913001600	Autotransporter beta-domain; Region: Autotransporter; pfam03797
637913001601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913001602	D-loop; other site
637913001603	H-loop/switch region; other site
637913001604	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
637913001605	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
637913001606	nucleotide binding pocket [chemical binding]; other site
637913001607	K-X-D-G motif; other site
637913001608	catalytic site [active]
637913001609	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
637913001610	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
637913001611	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
637913001612	Dimer interface [polypeptide binding]; other site
637913001613	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
637913001614	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637913001615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913001616	active site
637913001617	phosphorylation site [posttranslational modification]
637913001618	intermolecular recognition site; other site
637913001619	dimerization interface [polypeptide binding]; other site
637913001620	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
637913001621	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
637913001622	dimer interface [polypeptide binding]; other site
637913001623	anticodon binding site; other site
637913001624	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
637913001625	homodimer interface [polypeptide binding]; other site
637913001626	motif 1; other site
637913001627	active site
637913001628	motif 2; other site
637913001629	GAD domain; Region: GAD; pfam02938
637913001630	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
637913001631	active site
637913001632	motif 3; other site
637913001633	adenylate kinase; Reviewed; Region: adk; PRK00279
637913001634	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
637913001635	AMP-binding site [chemical binding]; other site
637913001636	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
637913001637	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
637913001638	Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306
637913001639	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
637913001640	dimer interface [polypeptide binding]; other site
637913001641	substrate binding site [chemical binding]; other site
637913001642	metal binding sites [ion binding]; metal-binding site
637913001643	MutS2 family protein; Region: mutS2; TIGR01069
637913001644	ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534
637913001645	Walker A/P-loop; other site
637913001646	ATP binding site [chemical binding]; other site
637913001647	Q-loop/lid; other site
637913001648	ABC transporter signature motif; other site
637913001649	Walker B; other site
637913001650	D-loop; other site
637913001651	H-loop/switch region; other site
637913001652	Smr domain; Region: Smr; pfam01713
637913001653	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
637913001654	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
637913001655	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637913001656	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637913001657	hypothetical protein; Provisional; Region: PRK05839
637913001658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637913001659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913001660	homodimer interface [polypeptide binding]; other site
637913001661	catalytic residue [active]
637913001662	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
637913001663	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
637913001664	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
637913001665	Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
637913001666	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
637913001667	putative trimer interface [polypeptide binding]; other site
637913001668	putative CoA binding site [chemical binding]; other site
637913001669	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913001670	Sel1-like repeats; Region: SEL1; smart00671
637913001671	Sel1-like repeats; Region: SEL1; smart00671
637913001672	Sel1 repeat; Region: Sel1; cl02723
637913001673	Sel1-like repeats; Region: SEL1; smart00671
637913001674	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913001675	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913001676	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
637913001677	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
637913001678	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
637913001679	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
637913001680	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
637913001681	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
637913001682	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
637913001683	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
637913001684	nickel binding site [ion binding]; other site
637913001685	putative substrate-binding site; other site
637913001686	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001687	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
637913001688	Ligand Binding Site [chemical binding]; other site
637913001689	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
637913001690	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
637913001691	active site
637913001692	NTP binding site [chemical binding]; other site
637913001693	metal binding triad [ion binding]; metal-binding site
637913001694	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
637913001695	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
637913001696	dimer interface [polypeptide binding]; other site
637913001697	FMN binding site [chemical binding]; other site
637913001698	glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410
637913001699	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637913001700	active site
637913001701	HIGH motif; other site
637913001702	nucleotide binding site [chemical binding]; other site
637913001703	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
637913001704	active site
637913001705	KMSKS motif; other site
637913001706	YGGT family; Region: YGGT; pfam02325
637913001707	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
637913001708	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637913001709	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637913001710	catalytic residue [active]
637913001711	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
637913001712	active site
637913001713	tetramer interface; other site
637913001714	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
637913001715	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
637913001716	hinge; other site
637913001717	active site
637913001718	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
637913001719	Aspartase; Region: Aspartase; cd01357
637913001720	active sites [active]
637913001721	tetramer interface [polypeptide binding]; other site
637913001722	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
637913001723	ligand binding site [chemical binding]; other site
637913001724	active site
637913001725	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
637913001726	phosphoserine phosphatase SerB; Region: serB; TIGR00338
637913001727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637913001728	motif II; other site
637913001729	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
637913001730	Ferritin-like domain; Region: Ferritin; pfam00210
637913001731	ferroxidase diiron center [ion binding]; other site
637913001732	hypothetical protein; Provisional; Region: PRK08444
637913001733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913001734	FeS/SAM binding site; other site
637913001735	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
637913001736	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637913001737	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637913001738	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637913001739	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637913001740	Surface antigen; Region: Bac_surface_Ag; pfam01103
637913001741	hypothetical protein; Provisional; Region: PRK08445
637913001742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913001743	FeS/SAM binding site; other site
637913001744	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637913001745	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637913001746	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637913001747	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
637913001748	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
637913001749	GatB domain; Region: GatB_Yqey; smart00845
637913001750	SurA N-terminal domain; Region: SurA_N; pfam09312
637913001751	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
637913001752	Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439
637913001753	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
637913001754	RNA/DNA hybrid binding site [nucleotide binding]; other site
637913001755	active site
637913001756	ribonuclease III; Reviewed; Region: rnc; PRK00102
637913001757	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
637913001758	dimerization interface [polypeptide binding]; other site
637913001759	active site
637913001760	metal binding site [ion binding]; metal-binding site
637913001761	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
637913001762	dsRNA binding site [nucleotide binding]; other site
637913001763	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
637913001764	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
637913001765	Tetramer interface [polypeptide binding]; other site
637913001766	active site
637913001767	FMN-binding site [chemical binding]; other site
637913001768	Protein of unknown function (DUF2603); Region: DUF2603; pfam10788
637913001769	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
637913001770	HemN C-terminal domain; Region: HemN_C; pfam06969
637913001771	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637913001772	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
637913001773	Cysteine-rich domain; Region: CCG; pfam02754
637913001774	Cysteine-rich domain; Region: CCG; pfam02754
637913001775	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001776	aspartate aminotransferase; Provisional; Region: PRK05764
637913001777	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637913001778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913001779	homodimer interface [polypeptide binding]; other site
637913001780	catalytic residue [active]
637913001781	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
637913001782	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637913001783	active site
637913001784	DNA binding site [nucleotide binding]
637913001785	Int/Topo IB signature motif; other site
637913001786	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
637913001787	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
637913001788	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
637913001789	DNA binding site [nucleotide binding]
637913001790	active site
637913001791	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637913001792	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
637913001793	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
637913001794	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
637913001795	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
637913001796	ATP cone domain; Region: ATP-cone; pfam03477
637913001797	Class I ribonucleotide reductase; Region: RNR_I; cd01679
637913001798	active site
637913001799	dimer interface [polypeptide binding]; other site
637913001800	catalytic residues [active]
637913001801	effector binding site; other site
637913001802	R2 peptide binding site; other site
637913001803	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359
637913001804	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
637913001805	Substrate binding site; other site
637913001806	Mg++ binding site; other site
637913001807	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
637913001808	active site
637913001809	substrate binding site [chemical binding]; other site
637913001810	CoA binding site [chemical binding]; other site
637913001811	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
637913001812	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
637913001813	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637913001814	N-terminal plug; other site
637913001815	ligand-binding site [chemical binding]; other site
637913001816	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
637913001817	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
637913001818	G1 box; other site
637913001819	GTP/Mg2+ binding site [chemical binding]; other site
637913001820	Switch I region; other site
637913001821	G2 box; other site
637913001822	G3 box; other site
637913001823	Switch II region; other site
637913001824	G4 box; other site
637913001825	G5 box; other site
637913001826	Nucleoside recognition; Region: Gate; pfam07670
637913001827	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
637913001828	Nucleoside recognition; Region: Gate; pfam07670
637913001829	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
637913001830	active site
637913001831	catalytic site [active]
637913001832	substrate binding site [chemical binding]; other site
637913001833	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
637913001834	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913001835	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913001836	CfrBI restriction endonuclease; Region: RE_CfrBI; pfam09516
637913001837	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
637913001838	putative acyltransferase; Provisional; Region: PRK05790
637913001839	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
637913001840	dimer interface [polypeptide binding]; other site
637913001841	active site
637913001842	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
637913001843	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
637913001844	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
637913001845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
637913001846	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
637913001847	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
637913001848	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
637913001849	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
637913001850	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
637913001851	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
637913001852	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
637913001853	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
637913001854	DNA gyrase subunit A; Validated; Region: PRK05560
637913001855	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
637913001856	CAP-like domain; other site
637913001857	active site
637913001858	primary dimer interface [polypeptide binding]; other site
637913001859	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001860	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001861	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001862	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001863	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001864	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637913001865	Response regulator receiver domain; Region: Response_reg; pfam00072
637913001866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913001867	active site
637913001868	phosphorylation site [posttranslational modification]
637913001869	intermolecular recognition site; other site
637913001870	dimerization interface [polypeptide binding]; other site
637913001871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001872	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
637913001873	Walker A motif; other site
637913001874	ATP binding site [chemical binding]; other site
637913001875	Walker B motif; other site
637913001876	arginine finger; other site
637913001877	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
637913001878	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
637913001879	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
637913001880	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
637913001881	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001882	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
637913001883	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
637913001884	Uncharacterized conserved protein [Function unknown]; Region: COG1912
637913001885	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
637913001886	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
637913001887	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001888	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
637913001889	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
637913001890	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
637913001891	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
637913001892	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
637913001893	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
637913001894	Walker A/P-loop; other site
637913001895	ATP binding site [chemical binding]; other site
637913001896	Q-loop/lid; other site
637913001897	ABC transporter signature motif; other site
637913001898	Walker B; other site
637913001899	D-loop; other site
637913001900	H-loop/switch region; other site
637913001901	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
637913001902	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
637913001903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913001904	Walker A motif; other site
637913001905	ATP binding site [chemical binding]; other site
637913001906	Walker B motif; other site
637913001907	arginine finger; other site
637913001908	LysE type translocator; Region: LysE; cl00565
637913001909	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
637913001910	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
637913001911	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
637913001912	active site
637913001913	homotetramer interface [polypeptide binding]; other site
637913001914	homodimer interface [polypeptide binding]; other site
637913001915	anaerobic c4-dicarboxylate membrane transporter family protein; Region: Dcu; TIGR00770
637913001916	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
637913001917	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913001918	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
637913001919	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
637913001920	FMN binding site [chemical binding]; other site
637913001921	active site
637913001922	catalytic residues [active]
637913001923	substrate binding site [chemical binding]; other site
637913001924	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
637913001925	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
637913001926	Ligand Binding Site [chemical binding]; other site
637913001927	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
637913001928	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
637913001929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913001930	FeS/SAM binding site; other site
637913001931	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
637913001932	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637913001933	active site
637913001934	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
637913001935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637913001936	catalytic residue [active]
637913001937	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
637913001938	tetramer interfaces [polypeptide binding]; other site
637913001939	binuclear metal-binding site [ion binding]; other site
637913001940	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
637913001941	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
637913001942	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637913001943	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637913001944	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
637913001945	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637913001946	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
637913001947	nucleotide binding site/active site [active]
637913001948	HIT family signature motif; other site
637913001949	catalytic residue [active]
637913001950	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
637913001951	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
637913001952	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637913001953	active site
637913001954	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
637913001955	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637913001956	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637913001957	active site
637913001958	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
637913001959	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
637913001960	Interdomain contacts; other site
637913001961	Cytokine receptor motif; other site
637913001962	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637913001963	Interdomain contacts; other site
637913001964	Cytokine receptor motif; other site
637913001965	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637913001966	Interdomain contacts; other site
637913001967	Cytokine receptor motif; other site
637913001968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913001969	S-adenosylmethionine binding site [chemical binding]; other site
637913001970	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637913001971	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637913001972	Walker A/P-loop; other site
637913001973	ATP binding site [chemical binding]; other site
637913001974	Q-loop/lid; other site
637913001975	ABC transporter signature motif; other site
637913001976	Walker B; other site
637913001977	D-loop; other site
637913001978	H-loop/switch region; other site
637913001979	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
637913001980	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637913001981	Peptidase family M23; Region: Peptidase_M23; pfam01551
637913001982	flagellar protein FlaG; Provisional; Region: PRK08452
637913001983	flagellar capping protein; Validated; Region: fliD; PRK08453
637913001984	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
637913001985	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
637913001986	flagellar biosynthetic protein FliS; Region: fliS; TIGR00208
637913001987	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
637913001988	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
637913001989	putative ATP binding site [chemical binding]; other site
637913001990	putative substrate interface [chemical binding]; other site
637913001991	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
637913001992	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
637913001993	putative active site; other site
637913001994	catalytic triad [active]
637913001995	putative dimer interface [polypeptide binding]; other site
637913001996	Predicted permease [General function prediction only]; Region: COG2056
637913001997	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
637913001998	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
637913001999	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
637913002000	phosphodiesterase; Provisional; Region: PRK12704
637913002001	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105
637913002002	nucleic acid binding region [nucleotide binding]; other site
637913002003	G-X-X-G motif; other site
637913002004	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637913002005	Zn2+ binding site [ion binding]; other site
637913002006	Mg2+ binding site [ion binding]; other site
637913002007	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
637913002008	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
637913002009	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
637913002010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
637913002011	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
637913002012	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637913002013	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
637913002014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913002015	FeS/SAM binding site; other site
637913002016	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
637913002017	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
637913002018	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
637913002019	GTP binding site; other site
637913002020	flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328
637913002021	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
637913002022	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
637913002023	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
637913002024	active site
637913002025	metal binding site [ion binding]; metal-binding site
637913002026	Nitronate monooxygenase; Region: NMO; pfam03060
637913002027	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
637913002028	FMN binding site [chemical binding]; other site
637913002029	substrate binding site [chemical binding]; other site
637913002030	putative catalytic residue [active]
637913002031	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
637913002032	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
637913002033	active site
637913002034	HIGH motif; other site
637913002035	dimer interface [polypeptide binding]; other site
637913002036	KMSKS motif; other site
637913002037	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637913002038	RNA binding surface [nucleotide binding]; other site
637913002039	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
637913002040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637913002041	Zn2+ binding site [ion binding]; other site
637913002042	Mg2+ binding site [ion binding]; other site
637913002043	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
637913002044	synthetase active site [active]
637913002045	NTP binding site [chemical binding]; other site
637913002046	metal binding site [ion binding]; metal-binding site
637913002047	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
637913002048	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
637913002049	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
637913002050	putative nucleotide binding site [chemical binding]; other site
637913002051	uridine monophosphate binding site [chemical binding]; other site
637913002052	homohexameric interface [polypeptide binding]; other site
637913002053	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
637913002054	aconitate hydratase 2; Region: acnB; TIGR00117
637913002055	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
637913002056	substrate binding site [chemical binding]; other site
637913002057	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
637913002058	substrate binding site [chemical binding]; other site
637913002059	ligand binding site [chemical binding]; other site
637913002060	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
637913002061	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913002062	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
637913002063	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
637913002064	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
637913002065	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
637913002066	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637913002067	nucleotide binding region [chemical binding]; other site
637913002068	ATP-binding site [chemical binding]; other site
637913002069	SEC-C motif; Region: SEC-C; pfam02810
637913002070	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
637913002071	FtsX-like permease family; Region: FtsX; pfam02687
637913002072	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913002073	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
637913002074	metal-binding site [ion binding]
637913002075	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
637913002076	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
637913002077	Soluble P-type ATPase [General function prediction only]; Region: COG4087
637913002078	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
637913002079	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
637913002080	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
637913002081	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
637913002082	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
637913002083	active site
637913002084	catalytic residues [active]
637913002085	metal binding site [ion binding]; metal-binding site
637913002086	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
637913002087	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
637913002088	oligomer interface [polypeptide binding]; other site
637913002089	active site residues [active]
637913002090	trigger factor; Provisional; Region: tig; PRK01490
637913002091	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637913002092	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
637913002093	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002094	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
637913002095	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
637913002096	trimer interface [polypeptide binding]; other site
637913002097	dimer interface [polypeptide binding]; other site
637913002098	putative active site [active]
637913002099	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
637913002100	MPT binding site; other site
637913002101	trimer interface [polypeptide binding]; other site
637913002102	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
637913002103	MoaE homodimer interface [polypeptide binding]; other site
637913002104	MoaD interaction [polypeptide binding]; other site
637913002105	active site residues [active]
637913002106	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
637913002107	MoaE interaction surface [polypeptide binding]; other site
637913002108	MoeB interaction surface [polypeptide binding]; other site
637913002109	thiocarboxylated glycine; other site
637913002110	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
637913002111	dimerization interface [polypeptide binding]; other site
637913002112	active site
637913002113	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
637913002114	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
637913002115	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: ribB; TIGR00506
637913002116	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
637913002117	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
637913002118	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
637913002119	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
637913002120	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
637913002121	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455
637913002122	RNA methyltransferase, RsmD family; Region: TIGR00095
637913002123	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
637913002124	Uncharacterized conserved protein [Function unknown]; Region: COG1565
637913002125	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637913002126	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
637913002127	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
637913002128	ATP binding site [chemical binding]; other site
637913002129	substrate interface [chemical binding]; other site
637913002130	flagellar motor protein MotA; Validated; Region: PRK08456
637913002131	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
637913002132	flagellar motor protein MotB; Reviewed; Region: motB; PRK08457
637913002133	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637913002134	ligand binding site [chemical binding]; other site
637913002135	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
637913002136	DEAD-like helicases superfamily; Region: DEXDc; smart00487
637913002137	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
637913002138	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913002139	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
637913002140	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913002141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913002142	dimer interface [polypeptide binding]; other site
637913002143	conserved gate region; other site
637913002144	ABC-ATPase subunit interface; other site
637913002145	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
637913002146	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637913002147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913002148	Walker A/P-loop; other site
637913002149	ATP binding site [chemical binding]; other site
637913002150	Q-loop/lid; other site
637913002151	ABC transporter signature motif; other site
637913002152	Walker B; other site
637913002153	D-loop; other site
637913002154	H-loop/switch region; other site
637913002155	excinuclease ABC, C subunit; Region: uvrC; TIGR00194
637913002156	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
637913002157	GIY-YIG motif/motif A; other site
637913002158	active site
637913002159	catalytic site [active]
637913002160	putative DNA binding site [nucleotide binding]; other site
637913002161	metal binding site [ion binding]; metal-binding site
637913002162	UvrB/uvrC motif; Region: UVR; pfam02151
637913002163	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
637913002164	homoserine dehydrogenase; Provisional; Region: PRK06349
637913002165	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
637913002166	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
637913002167	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
637913002168	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
637913002169	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637913002170	catalytic residues [active]
637913002171	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
637913002172	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637913002173	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637913002174	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
637913002175	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
637913002176	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
637913002177	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
637913002178	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
637913002179	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
637913002180	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
637913002181	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
637913002182	active site
637913002183	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
637913002184	indole acetimide hydrolase; Validated; Region: PRK07488
637913002185	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
637913002186	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
637913002187	CoA-binding site [chemical binding]; other site
637913002188	spermidine synthase; Provisional; Region: speE; PRK00536
637913002189	spermidine synthase; Provisional; Region: PRK00811
637913002190	GTP-binding protein Der; Reviewed; Region: PRK00093
637913002191	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
637913002192	G1 box; other site
637913002193	GTP/Mg2+ binding site [chemical binding]; other site
637913002194	Switch I region; other site
637913002195	G2 box; other site
637913002196	Switch II region; other site
637913002197	G3 box; other site
637913002198	G4 box; other site
637913002199	G5 box; other site
637913002200	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
637913002201	G1 box; other site
637913002202	GTP/Mg2+ binding site [chemical binding]; other site
637913002203	Switch I region; other site
637913002204	G2 box; other site
637913002205	G3 box; other site
637913002206	Switch II region; other site
637913002207	G4 box; other site
637913002208	G5 box; other site
637913002209	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
637913002210	IHF dimer interface [polypeptide binding]; other site
637913002211	IHF - DNA interface [nucleotide binding]; other site
637913002212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018
637913002213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018
637913002214	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
637913002215	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
637913002216	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
637913002217	NAD(P) binding site [chemical binding]; other site
637913002218	homodimer interface [polypeptide binding]; other site
637913002219	substrate binding site [chemical binding]; other site
637913002220	active site
637913002221	phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521
637913002222	Flavoprotein; Region: Flavoprotein; pfam02441
637913002223	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
637913002224	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
637913002225	thiamine phosphate binding site [chemical binding]; other site
637913002226	active site
637913002227	pyrophosphate binding site [ion binding]; other site
637913002228	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
637913002229	dimer interface [polypeptide binding]; other site
637913002230	substrate binding site [chemical binding]; other site
637913002231	ATP binding site [chemical binding]; other site
637913002232	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
637913002233	substrate binding site [chemical binding]; other site
637913002234	multimerization interface [polypeptide binding]; other site
637913002235	ATP binding site [chemical binding]; other site
637913002236	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
637913002237	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
637913002238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913002239	ATP binding site [chemical binding]; other site
637913002240	putative Mg++ binding site [ion binding]; other site
637913002241	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
637913002242	HsdM N-terminal domain; Region: HsdM_N; pfam12161
637913002243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002244	S-adenosylmethionine binding site [chemical binding]; other site
637913002245	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
637913002246	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637913002247	active site
637913002248	Protein of unknown function (DUF511); Region: DUF511; cl01114
637913002249	Transposase IS200 like; Region: Y1_Tnp; pfam01797
637913002250	Protein of unknown function (DUF511); Region: DUF511; cl01114
637913002251	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
637913002252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913002253	Walker A/P-loop; other site
637913002254	ATP binding site [chemical binding]; other site
637913002255	Q-loop/lid; other site
637913002256	ABC transporter signature motif; other site
637913002257	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637913002258	Walker B; other site
637913002259	D-loop; other site
637913002260	H-loop/switch region; other site
637913002261	ABC transporter; Region: ABC_tran_2; pfam12848
637913002262	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637913002263	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
637913002264	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
637913002265	dimer interface [polypeptide binding]; other site
637913002266	active site
637913002267	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
637913002268	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
637913002269	putative ribose interaction site [chemical binding]; other site
637913002270	putative ADP binding site [chemical binding]; other site
637913002271	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
637913002272	active site
637913002273	nucleotide binding site [chemical binding]; other site
637913002274	HIGH motif; other site
637913002275	KMSKS motif; other site
637913002276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637913002277	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
637913002278	NAD(P) binding site [chemical binding]; other site
637913002279	active site
637913002280	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
637913002281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637913002282	active site
637913002283	motif I; other site
637913002284	motif II; other site
637913002285	Uncharacterized conserved protein [Function unknown]; Region: COG2836
637913002286	pantothenate kinase; Reviewed; Region: PRK13333
637913002287	PQQ-like domain; Region: PQQ_2; pfam13360
637913002288	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
637913002289	trimer interface [polypeptide binding]; other site
637913002290	active site
637913002291	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
637913002292	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
637913002293	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
637913002294	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
637913002295	lipid-A-disaccharide synthase; Region: lpxB; TIGR00215
637913002296	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564
637913002297	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
637913002298	flagellar hook protein FlgE; Validated; Region: flgE; PRK08425
637913002299	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637913002300	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637913002301	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
637913002302	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637913002303	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
637913002304	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
637913002305	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
637913002306	PhnA protein; Region: PhnA; pfam03831
637913002307	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
637913002308	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
637913002309	tetramer interface [polypeptide binding]; other site
637913002310	heme binding pocket [chemical binding]; other site
637913002311	NADPH binding site [chemical binding]; other site
637913002312	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637913002313	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637913002314	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637913002315	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
637913002316	active site
637913002317	putative DNA-binding cleft [nucleotide binding]; other site
637913002318	dimer interface [polypeptide binding]; other site
637913002319	Uncharacterized conserved protein [Function unknown]; Region: COG1432
637913002320	LabA_like proteins; Region: LabA_like; cd06167
637913002321	putative metal binding site [ion binding]; other site
637913002322	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
637913002323	Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084
637913002324	RuvA N terminal domain; Region: RuvA_N; pfam01330
637913002325	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
637913002326	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
637913002327	MviN-like protein; Region: MVIN; pfam03023
637913002328	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
637913002329	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
637913002330	active site
637913002331	HIGH motif; other site
637913002332	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
637913002333	KMSKS motif; other site
637913002334	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
637913002335	tRNA binding surface [nucleotide binding]; other site
637913002336	anticodon binding site; other site
637913002337	Vacuolating cyotoxin; Region: VacA; pfam02691
637913002338	Autotransporter beta-domain; Region: Autotransporter; pfam03797
637913002339	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
637913002340	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
637913002341	Walker A/P-loop; other site
637913002342	ATP binding site [chemical binding]; other site
637913002343	Q-loop/lid; other site
637913002344	ABC transporter signature motif; other site
637913002345	Walker B; other site
637913002346	D-loop; other site
637913002347	H-loop/switch region; other site
637913002348	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
637913002349	ABC-ATPase subunit  interface; other site
637913002350	dimer interface [polypeptide binding]; other site
637913002351	putative PBP binding regions; other site
637913002352	short chain dehydrogenase; Validated; Region: PRK06182
637913002353	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
637913002354	NADP binding site [chemical binding]; other site
637913002355	active site
637913002356	steroid binding site; other site
637913002357	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
637913002358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
637913002359	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002360	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
637913002361	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
637913002362	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
637913002363	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
637913002364	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
637913002365	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
637913002366	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
637913002367	propionate/acetate kinase; Provisional; Region: PRK12379
637913002368	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
637913002369	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
637913002370	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
637913002371	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842
637913002372	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
637913002373	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
637913002374	flagellar hook protein FlgE; Validated; Region: flgE; PRK05841
637913002375	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637913002376	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
637913002377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002378	S-adenosylmethionine binding site [chemical binding]; other site
637913002379	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
637913002380	Part of AAA domain; Region: AAA_19; pfam13245
637913002381	Family description; Region: UvrD_C_2; pfam13538
637913002382	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002383	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002384	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913002385	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
637913002386	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637913002387	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637913002388	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
637913002389	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
637913002390	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637913002391	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637913002392	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
637913002393	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637913002394	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637913002395	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
637913002396	IMP binding site; other site
637913002397	dimer interface [polypeptide binding]; other site
637913002398	interdomain contacts; other site
637913002399	partial ornithine binding site; other site
637913002400	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
637913002401	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
637913002402	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
637913002403	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
637913002404	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637913002405	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913002406	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
637913002407	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913002408	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
637913002409	Putative vacuolating cytotoxin; Region: VacA2; pfam03077
637913002410	Autotransporter beta-domain; Region: Autotransporter; pfam03797
637913002411	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002412	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
637913002413	active site 1 [active]
637913002414	dimer interface [polypeptide binding]; other site
637913002415	hexamer interface [polypeptide binding]; other site
637913002416	active site 2 [active]
637913002417	recombination protein RecR; Region: recR; TIGR00615
637913002418	RecR protein; Region: RecR; pfam02132
637913002419	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
637913002420	putative active site [active]
637913002421	putative metal-binding site [ion binding]; other site
637913002422	tetramer interface [polypeptide binding]; other site
637913002423	tRNA pseudouridine synthase, TruD family; Region: tRNA_TruD_broad; TIGR00094
637913002424	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
637913002425	Permutation of conserved domain; other site
637913002426	active site
637913002427	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
637913002428	heat shock protein HtpX; Provisional; Region: PRK02870
637913002429	GTP cyclohydrolase I; Region: folE; TIGR00063
637913002430	GTP cyclohydrolase I; Provisional; Region: PLN03044
637913002431	active site
637913002432	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
637913002433	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
637913002434	substrate binding pocket [chemical binding]; other site
637913002435	chain length determination region; other site
637913002436	substrate-Mg2+ binding site; other site
637913002437	catalytic residues [active]
637913002438	aspartate-rich region 1; other site
637913002439	active site lid residues [active]
637913002440	aspartate-rich region 2; other site
637913002441	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
637913002442	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
637913002443	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
637913002444	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637913002445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637913002446	Coenzyme A binding pocket [chemical binding]; other site
637913002447	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637913002448	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913002450	putative substrate translocation pore; other site
637913002451	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913002452	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
637913002453	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913002454	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913002455	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
637913002456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913002457	dimer interface [polypeptide binding]; other site
637913002458	conserved gate region; other site
637913002459	putative PBP binding loops; other site
637913002460	ABC-ATPase subunit interface; other site
637913002461	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
637913002462	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637913002463	substrate binding pocket [chemical binding]; other site
637913002464	membrane-bound complex binding site; other site
637913002465	hinge residues; other site
637913002466	alanine racemase; Region: alr; TIGR00492
637913002467	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
637913002468	active site
637913002469	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637913002470	dimer interface [polypeptide binding]; other site
637913002471	substrate binding site [chemical binding]; other site
637913002472	catalytic residues [active]
637913002473	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
637913002474	amino acid carrier protein; Region: agcS; TIGR00835
637913002475	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
637913002476	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
637913002477	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
637913002478	homotrimer interaction site [polypeptide binding]; other site
637913002479	putative active site [active]
637913002480	TRL-like protein family; Region: TRL; pfam13146
637913002481	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
637913002482	Uncharacterized conserved protein [Function unknown]; Region: COG1576
637913002483	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
637913002484	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
637913002485	putative recombination protein RecO; Provisional; Region: PRK13908
637913002486	competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199
637913002487	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
637913002488	dimer interface [polypeptide binding]; other site
637913002489	FMN binding site [chemical binding]; other site
637913002490	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
637913002491	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637913002492	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637913002493	active site
637913002494	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
637913002495	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
637913002496	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637913002497	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
637913002498	Putative zinc ribbon domain; Region: DUF164; pfam02591
637913002499	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
637913002500	Uncharacterized conserved protein [Function unknown]; Region: COG0327
637913002501	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
637913002502	dimer interface [polypeptide binding]; other site
637913002503	motif 1; other site
637913002504	active site
637913002505	motif 2; other site
637913002506	motif 3; other site
637913002507	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
637913002508	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
637913002509	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
637913002510	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
637913002511	Dynamin family; Region: Dynamin_N; pfam00350
637913002512	G1 box; other site
637913002513	GTP/Mg2+ binding site [chemical binding]; other site
637913002514	G2 box; other site
637913002515	Switch I region; other site
637913002516	G3 box; other site
637913002517	Switch II region; other site
637913002518	G4 box; other site
637913002519	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
637913002520	G1 box; other site
637913002521	GTP/Mg2+ binding site [chemical binding]; other site
637913002522	G2 box; other site
637913002523	Switch I region; other site
637913002524	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
637913002525	G3 box; other site
637913002526	Switch II region; other site
637913002527	G4 box; other site
637913002528	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
637913002529	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
637913002530	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
637913002531	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
637913002532	Outer membrane efflux protein; Region: OEP; pfam02321
637913002533	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
637913002534	phosphoglyceromutase; Provisional; Region: PRK05434
637913002535	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
637913002536	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
637913002537	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
637913002538	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637913002539	inhibitor-cofactor binding pocket; inhibition site
637913002540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913002541	catalytic residue [active]
637913002542	SurA N-terminal domain; Region: SurA_N_3; cl07813
637913002543	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
637913002544	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
637913002545	cell division protein FtsA; Region: ftsA; TIGR01174
637913002546	Cell division protein FtsA; Region: FtsA; smart00842
637913002547	Cell division protein FtsA; Region: FtsA; pfam14450
637913002548	cell division protein FtsZ; Validated; Region: PRK09330
637913002549	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
637913002550	nucleotide binding site [chemical binding]; other site
637913002551	SulA interaction site; other site
637913002552	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637913002553	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
637913002554	generic binding surface II; other site
637913002555	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
637913002556	active site
637913002557	AAA domain; Region: AAA_33; pfam13671
637913002558	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
637913002559	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
637913002560	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
637913002561	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
637913002562	potential frameshift: common BLAST hit: gi|310819722|ref|YP_003952080.1| beta-catenin-interacting icat family protein
637913002563	AAA domain; Region: AAA_12; pfam13087
637913002564	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
637913002565	potential frameshift: common BLAST hit: gi|310819722|ref|YP_003952080.1| beta-catenin-interacting icat family protein
637913002566	AAA domain; Region: AAA_12; pfam13087
637913002567	AAA domain; Region: AAA_30; pfam13604
637913002568	Part of AAA domain; Region: AAA_19; pfam13245
637913002569	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
637913002570	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
637913002571	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
637913002572	active site
637913002573	ATP binding site [chemical binding]; other site
637913002574	substrate binding site [chemical binding]; other site
637913002575	activation loop (A-loop); other site
637913002576	Protein phosphatase 2C; Region: PP2C_2; pfam13672
637913002577	active site
637913002578	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
637913002579	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
637913002580	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
637913002581	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
637913002582	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
637913002583	metal ion-dependent adhesion site (MIDAS); other site
637913002584	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
637913002585	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
637913002586	active site
637913002587	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637913002588	catalytic residues [active]
637913002589	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
637913002590	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637913002591	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
637913002592	putative ADP-binding pocket [chemical binding]; other site
637913002593	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
637913002594	active site 2 [active]
637913002595	active site 1 [active]
637913002596	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637913002597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002598	S-adenosylmethionine binding site [chemical binding]; other site
637913002599	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
637913002600	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
637913002601	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
637913002602	active site
637913002603	HIGH motif; other site
637913002604	KMSKS motif; other site
637913002605	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
637913002606	anticodon binding site; other site
637913002607	tRNA binding surface [nucleotide binding]; other site
637913002608	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
637913002609	dimer interface [polypeptide binding]; other site
637913002610	putative tRNA-binding site [nucleotide binding]; other site
637913002611	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
637913002612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002613	S-adenosylmethionine binding site [chemical binding]; other site
637913002614	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
637913002615	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637913002616	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
637913002617	GMP synthase; Reviewed; Region: guaA; PRK00074
637913002618	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
637913002619	AMP/PPi binding site [chemical binding]; other site
637913002620	candidate oxyanion hole; other site
637913002621	catalytic triad [active]
637913002622	potential glutamine specificity residues [chemical binding]; other site
637913002623	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
637913002624	ATP Binding subdomain [chemical binding]; other site
637913002625	Ligand Binding sites [chemical binding]; other site
637913002626	Dimerization subdomain; other site
637913002627	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
637913002628	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
637913002629	molybdopterin cofactor binding site [chemical binding]; other site
637913002630	substrate binding site [chemical binding]; other site
637913002631	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
637913002632	molybdopterin cofactor binding site; other site
637913002633	Protein of unknown function (DUF3972); Region: DUF3972; pfam13118
637913002634	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
637913002635	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
637913002636	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637913002637	catalytic residue [active]
637913002638	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
637913002639	nucleotide binding site/active site [active]
637913002640	HIT family signature motif; other site
637913002641	catalytic residue [active]
637913002642	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
637913002643	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
637913002644	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
637913002645	dimer interface [polypeptide binding]; other site
637913002646	motif 1; other site
637913002647	active site
637913002648	motif 2; other site
637913002649	motif 3; other site
637913002650	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
637913002651	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
637913002652	putative tRNA-binding site [nucleotide binding]; other site
637913002653	tRNA synthetase B5 domain; Region: B5; pfam03484
637913002654	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
637913002655	dimer interface [polypeptide binding]; other site
637913002656	motif 1; other site
637913002657	motif 3; other site
637913002658	motif 2; other site
637913002659	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
637913002660	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
637913002661	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
637913002662	hinge; other site
637913002663	active site
637913002664	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
637913002665	LytB protein; Region: LYTB; pfam02401
637913002666	ribosomal protein S1; Region: rpsA; TIGR00717
637913002667	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
637913002668	RNA binding site [nucleotide binding]; other site
637913002669	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
637913002670	RNA binding site [nucleotide binding]; other site
637913002671	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
637913002672	RNA binding site [nucleotide binding]; other site
637913002673	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
637913002674	RNA binding site [nucleotide binding]; other site
637913002675	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
637913002676	RNA binding site [nucleotide binding]; other site
637913002677	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
637913002678	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
637913002679	ligand binding site [chemical binding]; other site
637913002680	NAD binding site [chemical binding]; other site
637913002681	dimerization interface [polypeptide binding]; other site
637913002682	catalytic site [active]
637913002683	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
637913002684	putative L-serine binding site [chemical binding]; other site
637913002685	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
637913002686	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
637913002687	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
637913002688	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637913002689	catalytic residue [active]
637913002690	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
637913002691	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637913002692	putative active site [active]
637913002693	putative metal binding site [ion binding]; other site
637913002694	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
637913002695	putative CheA interaction surface; other site
637913002696	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637913002697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913002698	active site
637913002699	phosphorylation site [posttranslational modification]
637913002700	intermolecular recognition site; other site
637913002701	dimerization interface [polypeptide binding]; other site
637913002702	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637913002703	putative binding surface; other site
637913002704	active site
637913002705	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
637913002706	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
637913002707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637913002708	ATP binding site [chemical binding]; other site
637913002709	Mg2+ binding site [ion binding]; other site
637913002710	G-X-G motif; other site
637913002711	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
637913002712	Response regulator receiver domain; Region: Response_reg; pfam00072
637913002713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913002714	active site
637913002715	phosphorylation site [posttranslational modification]
637913002716	intermolecular recognition site; other site
637913002717	dimerization interface [polypeptide binding]; other site
637913002718	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
637913002719	putative CheA interaction surface; other site
637913002720	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
637913002721	dimer interface [polypeptide binding]; other site
637913002722	catalytic triad [active]
637913002723	peroxidatic and resolving cysteines [active]
637913002724	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
637913002725	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
637913002726	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
637913002727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002728	S-adenosylmethionine binding site [chemical binding]; other site
637913002729	primosome assembly protein PriA; Validated; Region: PRK05580
637913002730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913002731	ATP binding site [chemical binding]; other site
637913002732	putative Mg++ binding site [ion binding]; other site
637913002733	helicase superfamily c-terminal domain; Region: HELICc; smart00490
637913002734	Sporulation related domain; Region: SPOR; pfam05036
637913002735	Peptidase family M48; Region: Peptidase_M48; pfam01435
637913002736	HemK family putative methylases; Region: hemK_fam; TIGR00536
637913002737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637913002738	glutamate dehydrogenase; Provisional; Region: PRK09414
637913002739	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
637913002740	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
637913002741	NAD(P) binding site [chemical binding]; other site
637913002742	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
637913002743	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
637913002744	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
637913002745	catalytic residues [active]
637913002746	ferrochelatase; Region: hemH; TIGR00109
637913002747	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
637913002748	C-terminal domain interface [polypeptide binding]; other site
637913002749	active site
637913002750	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
637913002751	active site
637913002752	N-terminal domain interface [polypeptide binding]; other site
637913002753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
637913002754	RNA methyltransferase, RsmE family; Region: TIGR00046
637913002755	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002756	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
637913002757	trimer interface [polypeptide binding]; other site
637913002758	active site
637913002759	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
637913002760	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
637913002761	carboxyltransferase (CT) interaction site; other site
637913002762	biotinylation site [posttranslational modification]; other site
637913002763	biotin carboxylase; Validated; Region: PRK08462
637913002764	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637913002765	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
637913002766	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637913002767	Methyltransferase domain; Region: Methyltransf_26; pfam13659
637913002768	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
637913002769	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
637913002770	inhibitor-cofactor binding pocket; inhibition site
637913002771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913002772	catalytic residue [active]
637913002773	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
637913002774	dimer interface [polypeptide binding]; other site
637913002775	putative radical transfer pathway; other site
637913002776	diiron center [ion binding]; other site
637913002777	tyrosyl radical; other site
637913002778	protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080
637913002779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913002780	S-adenosylmethionine binding site [chemical binding]; other site
637913002781	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
637913002782	Predicted permeases [General function prediction only]; Region: COG0795
637913002783	tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071
637913002784	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
637913002785	dimerization interface 3.5A [polypeptide binding]; other site
637913002786	active site
637913002787	UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179
637913002788	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
637913002789	NAD binding site [chemical binding]; other site
637913002790	homodimer interface [polypeptide binding]; other site
637913002791	active site
637913002792	substrate binding site [chemical binding]; other site
637913002793	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913002794	Sel1-like repeats; Region: SEL1; smart00671
637913002795	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913002796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913002797	binding surface
637913002798	TPR motif; other site
637913002799	Sel1-like repeats; Region: SEL1; smart00671
637913002800	Sel1 repeat; Region: Sel1; cl02723
637913002801	Sel1-like repeats; Region: SEL1; smart00671
637913002802	Entner-Doudoroff aldolase; Region: eda; TIGR01182
637913002803	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
637913002804	active site
637913002805	intersubunit interface [polypeptide binding]; other site
637913002806	catalytic residue [active]
637913002807	phosphogluconate dehydratase; Validated; Region: PRK09054
637913002808	6-phosphogluconate dehydratase; Region: edd; TIGR01196
637913002809	Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364
637913002810	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
637913002811	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
637913002812	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
637913002813	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
637913002814	putative active site [active]
637913002815	glucokinase; Provisional; Region: glk; PRK00292
637913002816	glucokinase, proteobacterial type; Region: glk; TIGR00749
637913002817	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
637913002818	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
637913002819	putative NAD(P) binding site [chemical binding]; other site
637913002820	putative substrate binding site [chemical binding]; other site
637913002821	catalytic Zn binding site [ion binding]; other site
637913002822	structural Zn binding site [ion binding]; other site
637913002823	dimer interface [polypeptide binding]; other site
637913002824	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913002825	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637913002826	active site
637913002827	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002828	pyruvate flavodoxin oxidoreductase subunit gamma; Validated; Region: PRK05844
637913002829	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
637913002830	pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625
637913002831	4Fe-4S binding domain; Region: Fer4; pfam00037
637913002832	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
637913002833	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
637913002834	dimer interface [polypeptide binding]; other site
637913002835	PYR/PP interface [polypeptide binding]; other site
637913002836	TPP binding site [chemical binding]; other site
637913002837	substrate binding site [chemical binding]; other site
637913002838	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637913002839	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
637913002840	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
637913002841	TPP-binding site [chemical binding]; other site
637913002842	putative dimer interface [polypeptide binding]; other site
637913002843	adenylosuccinate lyase; Provisional; Region: PRK08470
637913002844	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
637913002845	tetramer interface [polypeptide binding]; other site
637913002846	active site
637913002847	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
637913002848	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002849	excinuclease ABC subunit B; Provisional; Region: PRK05298
637913002850	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913002851	ATP binding site [chemical binding]; other site
637913002852	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
637913002853	putative Mg++ binding site [ion binding]; other site
637913002854	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637913002855	nucleotide binding region [chemical binding]; other site
637913002856	ATP-binding site [chemical binding]; other site
637913002857	Ultra-violet resistance protein B; Region: UvrB; pfam12344
637913002858	UvrB/uvrC motif; Region: UVR; pfam02151
637913002859	Protein of unknown function (DUF3519); Region: DUF3519; pfam12033
637913002860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913002861	binding surface
637913002862	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913002863	TPR motif; other site
637913002864	Sel1-like repeats; Region: SEL1; smart00671
637913002865	Sel1-like repeats; Region: SEL1; smart00671
637913002866	Sel1 repeat; Region: Sel1; cl02723
637913002867	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
637913002868	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
637913002869	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
637913002870	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637913002871	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
637913002872	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
637913002873	DNA binding site [nucleotide binding]
637913002874	substrate interaction site [chemical binding]; other site
637913002875	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
637913002876	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
637913002877	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637913002878	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
637913002879	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637913002880	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637913002881	ligand binding site [chemical binding]; other site
637913002882	translocation protein TolB; Provisional; Region: tolB; PRK04043
637913002883	TolB amino-terminal domain; Region: TolB_N; pfam04052
637913002884	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637913002885	TonB C terminal; Region: TonB_2; pfam13103
637913002886	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
637913002887	TolR protein; Region: tolR; TIGR02801
637913002888	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
637913002889	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
637913002890	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
637913002891	gamma subunit interface [polypeptide binding]; other site
637913002892	epsilon subunit interface [polypeptide binding]; other site
637913002893	LBP interface [polypeptide binding]; other site
637913002894	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
637913002895	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
637913002896	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
637913002897	alpha subunit interaction interface [polypeptide binding]; other site
637913002898	Walker A motif; other site
637913002899	ATP binding site [chemical binding]; other site
637913002900	Walker B motif; other site
637913002901	inhibitor binding site; inhibition site
637913002902	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
637913002903	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
637913002904	core domain interface [polypeptide binding]; other site
637913002905	delta subunit interface [polypeptide binding]; other site
637913002906	epsilon subunit interface [polypeptide binding]; other site
637913002907	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
637913002908	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
637913002909	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
637913002910	beta subunit interaction interface [polypeptide binding]; other site
637913002911	Walker A motif; other site
637913002912	ATP binding site [chemical binding]; other site
637913002913	Walker B motif; other site
637913002914	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
637913002915	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13431
637913002916	F0F1 ATP synthase subunit B; Validated; Region: PRK08475
637913002917	F0F1 ATP synthase subunit B'; Validated; Region: PRK08476
637913002918	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
637913002919	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
637913002920	ParB-like nuclease domain; Region: ParB; smart00470
637913002921	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
637913002922	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637913002923	P-loop; other site
637913002924	Magnesium ion binding site [ion binding]; other site
637913002925	biotin--protein ligase; Provisional; Region: PRK08477
637913002926	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
637913002927	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
637913002928	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
637913002929	putative active site [active]
637913002930	substrate binding site [chemical binding]; other site
637913002931	putative cosubstrate binding site; other site
637913002932	catalytic site [active]
637913002933	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
637913002934	substrate binding site [chemical binding]; other site
637913002935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
637913002936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913002937	Walker A/P-loop; other site
637913002938	ATP binding site [chemical binding]; other site
637913002939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
637913002940	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
637913002941	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
637913002942	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
637913002943	PRC-barrel domain; Region: PRC; pfam05239
637913002944	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
637913002945	KH domain; Region: KH_4; pfam13083
637913002946	G-X-X-G motif; other site
637913002947	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
637913002948	signal recognition particle protein; Provisional; Region: PRK10867
637913002949	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
637913002950	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
637913002951	P loop; other site
637913002952	GTP binding site [chemical binding]; other site
637913002953	Signal peptide binding domain; Region: SRP_SPB; pfam02978
637913002954	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
637913002955	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637913002956	active site
637913002957	HIGH motif; other site
637913002958	nucleotide binding site [chemical binding]; other site
637913002959	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
637913002960	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
637913002961	active site
637913002962	KMSKS motif; other site
637913002963	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
637913002964	anticodon binding site; other site
637913002965	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
637913002966	flagellar assembly protein FliW; Provisional; Region: PRK13283
637913002967	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
637913002968	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
637913002969	active site
637913002970	homodimer interface [polypeptide binding]; other site
637913002971	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002972	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913002973	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
637913002974	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
637913002975	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
637913002976	Fic/DOC family; Region: Fic; cl00960
637913002977	metal-binding heat shock protein; Provisional; Region: PRK00016
637913002978	flavodoxin FldA; Validated; Region: PRK09267
637913002979	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
637913002980	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
637913002981	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
637913002982	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
637913002983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637913002984	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637913002985	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
637913002986	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
637913002987	active site
637913002988	dimer interface [polypeptide binding]; other site
637913002989	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
637913002990	dimer interface [polypeptide binding]; other site
637913002991	active site
637913002992	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
637913002993	carbon starvation protein A; Provisional; Region: PRK15015
637913002994	Carbon starvation protein CstA; Region: CstA; pfam02554
637913002995	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
637913002996	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
637913002997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913002998	dimer interface [polypeptide binding]; other site
637913002999	conserved gate region; other site
637913003000	putative PBP binding loops; other site
637913003001	ABC-ATPase subunit interface; other site
637913003002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913003003	dimer interface [polypeptide binding]; other site
637913003004	conserved gate region; other site
637913003005	putative PBP binding loops; other site
637913003006	ABC-ATPase subunit interface; other site
637913003007	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
637913003008	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
637913003009	Walker A/P-loop; other site
637913003010	ATP binding site [chemical binding]; other site
637913003011	Q-loop/lid; other site
637913003012	ABC transporter signature motif; other site
637913003013	Walker B; other site
637913003014	D-loop; other site
637913003015	H-loop/switch region; other site
637913003016	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
637913003017	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637913003018	substrate binding pocket [chemical binding]; other site
637913003019	membrane-bound complex binding site; other site
637913003020	hinge residues; other site
637913003021	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
637913003022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913003023	putative substrate translocation pore; other site
637913003024	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
637913003025	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003026	purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107
637913003027	phosphopentomutase; Provisional; Region: PRK05362
637913003028	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
637913003029	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
637913003030	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
637913003031	Nucleoside recognition; Region: Gate; pfam07670
637913003032	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
637913003033	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
637913003034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913003035	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637913003036	putative substrate translocation pore; other site
637913003037	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
637913003038	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
637913003039	Ligand Binding Site [chemical binding]; other site
637913003040	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
637913003041	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
637913003042	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
637913003043	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
637913003044	putative arabinose transporter; Provisional; Region: PRK03545
637913003045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913003046	putative substrate translocation pore; other site
637913003047	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
637913003048	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
637913003049	active site
637913003050	zinc binding site [ion binding]; other site
637913003051	aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296
637913003052	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
637913003053	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
637913003054	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
637913003055	dimer interface [polypeptide binding]; other site
637913003056	motif 1; other site
637913003057	active site
637913003058	motif 2; other site
637913003059	motif 3; other site
637913003060	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
637913003061	anticodon binding site; other site
637913003062	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913003063	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
637913003064	putative active site [active]
637913003065	elongation factor G; Reviewed; Region: PRK00007
637913003066	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
637913003067	G1 box; other site
637913003068	putative GEF interaction site [polypeptide binding]; other site
637913003069	GTP/Mg2+ binding site [chemical binding]; other site
637913003070	Switch I region; other site
637913003071	G2 box; other site
637913003072	G3 box; other site
637913003073	Switch II region; other site
637913003074	G4 box; other site
637913003075	G5 box; other site
637913003076	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
637913003077	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
637913003078	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
637913003079	30S ribosomal protein S7; Validated; Region: PRK05302
637913003080	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
637913003081	S17 interaction site [polypeptide binding]; other site
637913003082	S8 interaction site; other site
637913003083	16S rRNA interaction site [nucleotide binding]; other site
637913003084	streptomycin interaction site [chemical binding]; other site
637913003085	23S rRNA interaction site [nucleotide binding]; other site
637913003086	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
637913003087	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
637913003088	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
637913003089	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
637913003090	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
637913003091	RPB11 interaction site [polypeptide binding]; other site
637913003092	RPB12 interaction site [polypeptide binding]; other site
637913003093	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
637913003094	RPB3 interaction site [polypeptide binding]; other site
637913003095	RPB1 interaction site [polypeptide binding]; other site
637913003096	RPB11 interaction site [polypeptide binding]; other site
637913003097	RPB10 interaction site [polypeptide binding]; other site
637913003098	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
637913003099	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
637913003100	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
637913003101	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
637913003102	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
637913003103	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
637913003104	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
637913003105	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
637913003106	DNA binding site [nucleotide binding]
637913003107	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
637913003108	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
637913003109	core dimer interface [polypeptide binding]; other site
637913003110	peripheral dimer interface [polypeptide binding]; other site
637913003111	L10 interface [polypeptide binding]; other site
637913003112	L11 interface [polypeptide binding]; other site
637913003113	putative EF-Tu interaction site [polypeptide binding]; other site
637913003114	putative EF-G interaction site [polypeptide binding]; other site
637913003115	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
637913003116	23S rRNA interface [nucleotide binding]; other site
637913003117	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
637913003118	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
637913003119	mRNA/rRNA interface [nucleotide binding]; other site
637913003120	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
637913003121	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
637913003122	23S rRNA interface [nucleotide binding]; other site
637913003123	L7/L12 interface [polypeptide binding]; other site
637913003124	putative thiostrepton binding site; other site
637913003125	L25 interface [polypeptide binding]; other site
637913003126	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
637913003127	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
637913003128	putative homodimer interface [polypeptide binding]; other site
637913003129	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
637913003130	heterodimer interface [polypeptide binding]; other site
637913003131	homodimer interface [polypeptide binding]; other site
637913003132	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
637913003133	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
637913003134	elongation factor Tu; Reviewed; Region: PRK00049
637913003135	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
637913003136	G1 box; other site
637913003137	GEF interaction site [polypeptide binding]; other site
637913003138	GTP/Mg2+ binding site [chemical binding]; other site
637913003139	Switch I region; other site
637913003140	G2 box; other site
637913003141	G3 box; other site
637913003142	Switch II region; other site
637913003143	G4 box; other site
637913003144	G5 box; other site
637913003145	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
637913003146	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
637913003147	Antibiotic Binding Site [chemical binding]; other site
637913003148	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
637913003149	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
637913003150	Walker A/P-loop; other site
637913003151	ATP binding site [chemical binding]; other site
637913003152	Q-loop/lid; other site
637913003153	ABC transporter signature motif; other site
637913003154	Walker B; other site
637913003155	D-loop; other site
637913003156	H-loop/switch region; other site
637913003157	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
637913003158	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
637913003159	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
637913003160	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086
637913003161	serine O-acetyltransferase; Region: cysE; TIGR01172
637913003162	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
637913003163	trimer interface [polypeptide binding]; other site
637913003164	active site
637913003165	substrate binding site [chemical binding]; other site
637913003166	CoA binding site [chemical binding]; other site
637913003167	F0F1 ATP synthase subunit C; Validated; Region: PRK08482
637913003168	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
637913003169	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
637913003170	oligomer interface [polypeptide binding]; other site
637913003171	RNA binding site [nucleotide binding]; other site
637913003172	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
637913003173	oligomer interface [polypeptide binding]; other site
637913003174	RNA binding site [nucleotide binding]; other site
637913003175	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
637913003176	putative nucleic acid binding region [nucleotide binding]; other site
637913003177	G-X-X-G motif; other site
637913003178	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
637913003179	RNA binding site [nucleotide binding]; other site
637913003180	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
637913003181	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
637913003182	Organic solvent tolerance protein; Region: OstA_C; pfam04453
637913003183	Predicted membrane protein/domain [Function unknown]; Region: COG1714
637913003184	phosphoribosylamine--glycine ligase; Region: purD; TIGR00877
637913003185	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
637913003186	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
637913003187	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
637913003188	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
637913003189	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
637913003190	Walker A/P-loop; other site
637913003191	ATP binding site [chemical binding]; other site
637913003192	Q-loop/lid; other site
637913003193	ABC transporter signature motif; other site
637913003194	Walker B; other site
637913003195	D-loop; other site
637913003196	H-loop/switch region; other site
637913003197	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
637913003198	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
637913003199	catalytic residue [active]
637913003200	putative FPP diphosphate  binding site; other site
637913003201	putative FPP binding hydrophobic cleft; other site
637913003202	dimer interface [polypeptide binding]; other site
637913003203	putative IPP diphosphate binding site; other site
637913003204	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
637913003205	FAD binding domain; Region: FAD_binding_4; pfam01565
637913003206	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
637913003207	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637913003208	active site residue [active]
637913003209	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
637913003210	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
637913003211	active site
637913003212	camphor resistance protein CrcB; Provisional; Region: PRK14204
637913003213	coproporphyrinogen III oxidase; Provisional; Region: PRK08446
637913003214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913003215	FeS/SAM binding site; other site
637913003216	HemN C-terminal domain; Region: HemN_C; pfam06969
637913003217	Cytochrome c553 [Energy production and conversion]; Region: COG2863
637913003218	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
637913003219	putative active site [active]
637913003220	Ap4A binding site [chemical binding]; other site
637913003221	nudix motif; other site
637913003222	putative metal binding site [ion binding]; other site
637913003223	aspartate kinase; Reviewed; Region: PRK06635
637913003224	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
637913003225	putative nucleotide binding site [chemical binding]; other site
637913003226	putative catalytic residues [active]
637913003227	putative Mg ion binding site [ion binding]; other site
637913003228	putative aspartate binding site [chemical binding]; other site
637913003229	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
637913003230	putative allosteric regulatory site; other site
637913003231	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
637913003232	putative allosteric regulatory residue; other site
637913003233	DNA replication regulator; Region: HobA; pfam12163
637913003234	DNA polymerase III subunit delta'; Validated; Region: PRK08485
637913003235	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
637913003236	dihydropteroate synthase; Region: DHPS; TIGR01496
637913003237	substrate binding pocket [chemical binding]; other site
637913003238	dimer interface [polypeptide binding]; other site
637913003239	inhibitor binding site; inhibition site
637913003240	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
637913003241	EamA-like transporter family; Region: EamA; pfam00892
637913003242	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
637913003243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952
637913003244	Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505
637913003245	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
637913003246	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
637913003247	catalytic site [active]
637913003248	subunit interface [polypeptide binding]; other site
637913003249	formamidase; Provisional; Region: amiF; PRK13287
637913003250	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
637913003251	multimer interface [polypeptide binding]; other site
637913003252	active site
637913003253	catalytic triad [active]
637913003254	dimer interface [polypeptide binding]; other site
637913003255	Maf-like protein; Reviewed; Region: PRK04056
637913003256	putative active site [active]
637913003257	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
637913003258	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
637913003259	motif 1; other site
637913003260	active site
637913003261	motif 2; other site
637913003262	motif 3; other site
637913003263	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
637913003264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
637913003265	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003266	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
637913003267	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
637913003268	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
637913003269	dimer interface [polypeptide binding]; other site
637913003270	ssDNA binding site [nucleotide binding]; other site
637913003271	tetramer (dimer of dimers) interface [polypeptide binding]; other site
637913003272	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
637913003273	DNA polymerase III subunit delta; Validated; Region: PRK08487
637913003274	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
637913003275	Exoribonuclease R [Transcription]; Region: VacB; COG0557
637913003276	RNB domain; Region: RNB; pfam00773
637913003277	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
637913003278	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
637913003279	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
637913003280	shikimate binding site; other site
637913003281	NAD(P) binding site [chemical binding]; other site
637913003282	Bacterial SH3 domain; Region: SH3_3; pfam08239
637913003283	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
637913003284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637913003285	dimer interface [polypeptide binding]; other site
637913003286	conserved gate region; other site
637913003287	putative PBP binding loops; other site
637913003288	ABC-ATPase subunit interface; other site
637913003289	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
637913003290	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
637913003291	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
637913003292	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
637913003293	active site
637913003294	HIGH motif; other site
637913003295	dimer interface [polypeptide binding]; other site
637913003296	KMSKS motif; other site
637913003297	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
637913003298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637913003299	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
637913003300	ribosome recycling factor; Reviewed; Region: frr; PRK00083
637913003301	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
637913003302	hinge region; other site
637913003303	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637913003304	active site
637913003305	RDD family; Region: RDD; pfam06271
637913003306	NAD-dependent deacetylase; Provisional; Region: PRK00481
637913003307	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
637913003308	NAD+ binding site [chemical binding]; other site
637913003309	substrate binding site [chemical binding]; other site
637913003310	Zn binding site [ion binding]; other site
637913003311	NADH dehydrogenase subunit A; Validated; Region: PRK08489
637913003312	NADH dehydrogenase subunit B; Validated; Region: PRK06411
637913003313	NADH dehydrogenase subunit C; Provisional; Region: PRK08491
637913003314	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
637913003315	NADH dehydrogenase subunit D; Validated; Region: PRK06075
637913003316	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
637913003317	NADH dehydrogenase subunit G; Validated; Region: PRK08493
637913003318	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637913003319	catalytic loop [active]
637913003320	iron binding site [ion binding]; other site
637913003321	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
637913003322	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
637913003323	molybdopterin cofactor binding site; other site
637913003324	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
637913003325	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
637913003326	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
637913003327	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
637913003328	4Fe-4S binding domain; Region: Fer4; cl02805
637913003329	4Fe-4S binding domain; Region: Fer4; pfam00037
637913003330	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
637913003331	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
637913003332	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
637913003333	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
637913003334	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
637913003335	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637913003336	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
637913003337	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637913003338	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
637913003339	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637913003340	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
637913003341	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
637913003342	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
637913003343	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
637913003344	active site
637913003345	substrate binding site [chemical binding]; other site
637913003346	metal binding site [ion binding]; metal-binding site
637913003347	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
637913003348	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
637913003349	substrate binding site [chemical binding]; other site
637913003350	active site
637913003351	catalytic residues [active]
637913003352	heterodimer interface [polypeptide binding]; other site
637913003353	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
637913003354	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
637913003355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637913003356	catalytic residue [active]
637913003357	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
637913003358	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
637913003359	active site
637913003360	ribulose/triose binding site [chemical binding]; other site
637913003361	phosphate binding site [ion binding]; other site
637913003362	substrate (anthranilate) binding pocket [chemical binding]; other site
637913003363	product (indole) binding pocket [chemical binding]; other site
637913003364	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
637913003365	active site
637913003366	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
637913003367	anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245
637913003368	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
637913003369	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
637913003370	catalytic triad [active]
637913003371	glutamine binding [chemical binding]; other site
637913003372	anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565
637913003373	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
637913003374	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
637913003375	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913003376	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637913003377	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637913003378	active site
637913003379	motif I; other site
637913003380	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
637913003381	motif II; other site
637913003382	Uncharacterized conserved protein [Function unknown]; Region: COG2353
637913003383	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
637913003384	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
637913003385	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
637913003386	Thiamine pyrophosphokinase; Region: TPK; cd07995
637913003387	active site
637913003388	dimerization interface [polypeptide binding]; other site
637913003389	thiamine binding site [chemical binding]; other site
637913003390	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
637913003391	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
637913003392	alphaNTD homodimer interface [polypeptide binding]; other site
637913003393	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
637913003394	alphaNTD - beta interaction site [polypeptide binding]; other site
637913003395	alphaNTD - beta' interaction site [polypeptide binding]; other site
637913003396	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
637913003397	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
637913003398	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
637913003399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637913003400	RNA binding surface [nucleotide binding]; other site
637913003401	30S ribosomal protein S11; Validated; Region: PRK05309
637913003402	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
637913003403	30S ribosomal protein S13; Region: bact_S13; TIGR03631
637913003404	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
637913003405	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
637913003406	rRNA binding site [nucleotide binding]; other site
637913003407	predicted 30S ribosome binding site; other site
637913003408	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
637913003409	active site
637913003410	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
637913003411	SecY translocase; Region: SecY; pfam00344
637913003412	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
637913003413	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
637913003414	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
637913003415	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
637913003416	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
637913003417	23S rRNA interface [nucleotide binding]; other site
637913003418	5S rRNA interface [nucleotide binding]; other site
637913003419	L27 interface [polypeptide binding]; other site
637913003420	L5 interface [polypeptide binding]; other site
637913003421	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
637913003422	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
637913003423	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
637913003424	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
637913003425	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
637913003426	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
637913003427	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
637913003428	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
637913003429	RNA binding site [nucleotide binding]; other site
637913003430	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
637913003431	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
637913003432	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
637913003433	putative translocon interaction site; other site
637913003434	23S rRNA interface [nucleotide binding]; other site
637913003435	signal recognition particle (SRP54) interaction site; other site
637913003436	L23 interface [polypeptide binding]; other site
637913003437	trigger factor interaction site; other site
637913003438	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
637913003439	23S rRNA interface [nucleotide binding]; other site
637913003440	5S rRNA interface [nucleotide binding]; other site
637913003441	putative antibiotic binding site [chemical binding]; other site
637913003442	L25 interface [polypeptide binding]; other site
637913003443	L27 interface [polypeptide binding]; other site
637913003444	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
637913003445	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
637913003446	G-X-X-G motif; other site
637913003447	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
637913003448	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
637913003449	putative translocon binding site; other site
637913003450	protein-rRNA interface [nucleotide binding]; other site
637913003451	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
637913003452	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
637913003453	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
637913003454	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
637913003455	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
637913003456	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
637913003457	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
637913003458	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
637913003459	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
637913003460	AAA domain; Region: AAA_14; pfam13173
637913003461	Helix-turn-helix domain; Region: HTH_36; pfam13730
637913003462	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
637913003463	RNA/DNA hybrid binding site [nucleotide binding]; other site
637913003464	active site
637913003465	fumarate hydratase; Reviewed; Region: fumC; PRK00485
637913003466	Class II fumarases; Region: Fumarase_classII; cd01362
637913003467	active site
637913003468	tetramer interface [polypeptide binding]; other site
637913003469	YtkA-like; Region: YtkA; pfam13115
637913003470	Outer membrane efflux protein; Region: OEP; pfam02321
637913003471	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
637913003472	HlyD family secretion protein; Region: HlyD_3; pfam13437
637913003473	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
637913003474	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
637913003475	AzlC protein; Region: AzlC; cl00570
637913003476	chaperone protein DnaJ; Provisional; Region: PRK14288
637913003477	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
637913003478	HSP70 interaction site [polypeptide binding]; other site
637913003479	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
637913003480	substrate binding site [polypeptide binding]; other site
637913003481	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
637913003482	Zn binding sites [ion binding]; other site
637913003483	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
637913003484	substrate binding site [polypeptide binding]; other site
637913003485	dimer interface [polypeptide binding]; other site
637913003486	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
637913003487	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
637913003488	Ligand Binding Site [chemical binding]; other site
637913003489	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
637913003490	HSP70 interaction site [polypeptide binding]; other site
637913003491	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
637913003492	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
637913003493	active site
637913003494	(T/H)XGH motif; other site
637913003495	nickel responsive regulator; Provisional; Region: PRK00630
637913003496	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
637913003497	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
637913003498	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
637913003499	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
637913003500	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
637913003501	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
637913003502	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
637913003503	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003504	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
637913003505	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
637913003506	Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836
637913003507	Cl binding site [ion binding]; other site
637913003508	oligomer interface [polypeptide binding]; other site
637913003509	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
637913003510	Phosphoglycerate kinase; Region: PGK; pfam00162
637913003511	substrate binding site [chemical binding]; other site
637913003512	hinge regions; other site
637913003513	ADP binding site [chemical binding]; other site
637913003514	catalytic site [active]
637913003515	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
637913003516	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
637913003517	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637913003518	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
637913003519	ligand binding site [chemical binding]; other site
637913003520	active site
637913003521	UGI interface [polypeptide binding]; other site
637913003522	catalytic site [active]
637913003523	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
637913003524	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637913003525	putative acyl-acceptor binding pocket; other site
637913003526	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
637913003527	C-terminal peptidase (prc); Region: prc; TIGR00225
637913003528	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
637913003529	protein binding site [polypeptide binding]; other site
637913003530	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
637913003531	Catalytic dyad [active]
637913003532	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913003533	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913003534	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848
637913003535	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
637913003536	dimerization interface [polypeptide binding]; other site
637913003537	active site
637913003538	Quinolinate synthetase A protein; Region: NadA; cl00420
637913003539	phosphatidylserine decarboxylase; Provisional; Region: PRK03934
637913003540	prenyltransferase; Reviewed; Region: ubiA; PRK12874
637913003541	UbiA prenyltransferase family; Region: UbiA; pfam01040
637913003542	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
637913003543	Competence protein; Region: Competence; pfam03772
637913003544	replicative DNA helicase; Provisional; Region: PRK08506
637913003545	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
637913003546	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
637913003547	Walker A motif; other site
637913003548	ATP binding site [chemical binding]; other site
637913003549	Walker B motif; other site
637913003550	DNA binding loops [nucleotide binding]
637913003551	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
637913003552	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
637913003553	putative substrate binding site [chemical binding]; other site
637913003554	putative ATP binding site [chemical binding]; other site
637913003555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637913003556	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
637913003557	dimer interface [polypeptide binding]; other site
637913003558	phosphorylation site [posttranslational modification]
637913003559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637913003560	ATP binding site [chemical binding]; other site
637913003561	Mg2+ binding site [ion binding]; other site
637913003562	G-X-G motif; other site
637913003563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637913003564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637913003565	active site
637913003566	phosphorylation site [posttranslational modification]
637913003567	intermolecular recognition site; other site
637913003568	dimerization interface [polypeptide binding]; other site
637913003569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637913003570	DNA binding site [nucleotide binding]
637913003571	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913003572	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913003573	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
637913003574	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913003575	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913003576	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637913003577	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913003578	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637913003579	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637913003580	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
637913003581	rod shape-determining protein MreC; Region: MreC; pfam04085
637913003582	rod shape-determining protein MreB; Provisional; Region: PRK13927
637913003583	MreB and similar proteins; Region: MreB_like; cd10225
637913003584	nucleotide binding site [chemical binding]; other site
637913003585	Mg binding site [ion binding]; other site
637913003586	putative protofilament interaction site [polypeptide binding]; other site
637913003587	RodZ interaction site [polypeptide binding]; other site
637913003588	endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382
637913003589	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
637913003590	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
637913003591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913003592	Walker A motif; other site
637913003593	ATP binding site [chemical binding]; other site
637913003594	Walker B motif; other site
637913003595	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
637913003596	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
637913003597	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
637913003598	active site
637913003599	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
637913003600	flagellar assembly protein FliW; Provisional; Region: PRK13282
637913003601	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
637913003602	ATP-dependent protease La; Region: lon; TIGR00763
637913003603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913003604	Walker A motif; other site
637913003605	ATP binding site [chemical binding]; other site
637913003606	Walker B motif; other site
637913003607	arginine finger; other site
637913003608	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
637913003609	prephenate dehydrogenase; Validated; Region: PRK08507
637913003610	Prephenate dehydrogenase; Region: PDH; pfam02153
637913003611	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
637913003612	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
637913003613	active site
637913003614	substrate binding site [chemical binding]; other site
637913003615	Mg2+ binding site [ion binding]; other site
637913003616	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
637913003617	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
637913003618	DNA methylase; Region: N6_N4_Mtase; pfam01555
637913003619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
637913003620	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
637913003621	ATP binding site [chemical binding]; other site
637913003622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
637913003623	putative Mg++ binding site [ion binding]; other site
637913003624	biotin synthase; Provisional; Region: PRK08508
637913003625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913003626	FeS/SAM binding site; other site
637913003627	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
637913003628	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
637913003629	7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139
637913003630	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
637913003631	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
637913003632	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913003633	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
637913003634	Ligand binding site; other site
637913003635	metal-binding site
637913003636	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
637913003637	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
637913003638	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904
637913003639	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
637913003640	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
637913003641	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472
637913003642	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
637913003643	Walker A motif/ATP binding site; other site
637913003644	Walker B motif; other site
637913003645	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
637913003646	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
637913003647	ATP binding site [chemical binding]; other site
637913003648	Walker A motif; other site
637913003649	hexamer interface [polypeptide binding]; other site
637913003650	Walker B motif; other site
637913003651	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
637913003652	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637913003653	active site
637913003654	HIGH motif; other site
637913003655	nucleotide binding site [chemical binding]; other site
637913003656	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
637913003657	active site
637913003658	KMSKS motif; other site
637913003659	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
637913003660	tRNA binding surface [nucleotide binding]; other site
637913003661	anticodon binding site; other site
637913003662	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
637913003663	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637913003664	RNA binding surface [nucleotide binding]; other site
637913003665	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
637913003666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637913003667	FeS/SAM binding site; other site
637913003668	KpsF/GutQ family protein; Region: kpsF; TIGR00393
637913003669	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
637913003670	putative active site [active]
637913003671	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
637913003672	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
637913003673	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637913003674	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
637913003675	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
637913003676	dimethyladenosine transferase; Region: ksgA; TIGR00755
637913003677	S-adenosylmethionine binding site [chemical binding]; other site
637913003678	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
637913003679	Protein of unknown function DUF45; Region: DUF45; pfam01863
637913003680	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
637913003681	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637913003682	N-terminal plug; other site
637913003683	ligand-binding site [chemical binding]; other site
637913003684	Arginase family; Region: Arginase; cd09989
637913003685	active site
637913003686	Mn binding site [ion binding]; other site
637913003687	oligomer interface [polypeptide binding]; other site
637913003688	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
637913003689	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
637913003690	hexamer interface [polypeptide binding]; other site
637913003691	ligand binding site [chemical binding]; other site
637913003692	putative active site [active]
637913003693	NAD(P) binding site [chemical binding]; other site
637913003694	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913003695	Protein of unknown function DUF262; Region: DUF262; pfam03235
637913003696	Uncharacterized conserved protein [Function unknown]; Region: COG1479
637913003697	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
637913003698	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003699	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
637913003700	ATP-NAD kinase; Region: NAD_kinase; pfam01513
637913003701	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
637913003702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637913003703	Walker A/P-loop; other site
637913003704	ATP binding site [chemical binding]; other site
637913003705	Q-loop/lid; other site
637913003706	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
637913003707	ABC transporter signature motif; other site
637913003708	Walker B; other site
637913003709	D-loop; other site
637913003710	H-loop/switch region; other site
637913003711	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
637913003712	Domain of unknown function (DUF814); Region: DUF814; pfam05670
637913003713	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637913003714	DNA polymerase III subunit epsilon; Provisional; Region: PRK08517
637913003715	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
637913003716	active site
637913003717	catalytic site [active]
637913003718	substrate binding site [chemical binding]; other site
637913003719	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
637913003720	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
637913003721	substrate binding site [chemical binding]; other site
637913003722	hexamer interface [polypeptide binding]; other site
637913003723	metal binding site [ion binding]; metal-binding site
637913003724	Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: Fbp; COG0158
637913003725	active site
637913003726	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
637913003727	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
637913003728	tandem repeat interface [polypeptide binding]; other site
637913003729	oligomer interface [polypeptide binding]; other site
637913003730	active site residues [active]
637913003731	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
637913003732	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
637913003733	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
637913003734	putative active site [active]
637913003735	putative substrate binding site [chemical binding]; other site
637913003736	putative cosubstrate binding site; other site
637913003737	catalytic site [active]
637913003738	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
637913003739	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
637913003740	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
637913003741	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
637913003742	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
637913003743	glutaminase active site [active]
637913003744	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
637913003745	dimer interface [polypeptide binding]; other site
637913003746	active site
637913003747	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
637913003748	dimer interface [polypeptide binding]; other site
637913003749	active site
637913003750	Protein of unknown function (DUF2443); Region: DUF2443; pfam10398
637913003751	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
637913003752	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
637913003753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637913003754	Walker A motif; other site
637913003755	ATP binding site [chemical binding]; other site
637913003756	Walker B motif; other site
637913003757	arginine finger; other site
637913003758	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
637913003759	DnaA box-binding interface [nucleotide binding]; other site
637913003760	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
637913003761	active site
637913003762	putative catalytic site [active]
637913003763	DNA binding site [nucleotide binding]
637913003764	putative phosphate binding site [ion binding]; other site
637913003765	metal binding site A [ion binding]; metal-binding site
637913003766	AP binding site [nucleotide binding]; other site
637913003767	metal binding site B [ion binding]; metal-binding site
637913003768	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003769	ATP-dependent DNA helicase RecG; Region: recG; TIGR00643
637913003770	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
637913003771	ssDNA binding site; other site
637913003772	generic binding surface II; other site
637913003773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913003774	ATP binding site [chemical binding]; other site
637913003775	putative Mg++ binding site [ion binding]; other site
637913003776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637913003777	nucleotide binding region [chemical binding]; other site
637913003778	ATP-binding site [chemical binding]; other site
637913003779	Restriction endonuclease [Defense mechanisms]; Region: COG3587
637913003780	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913003781	ATP binding site [chemical binding]; other site
637913003782	putative Mg++ binding site [ion binding]; other site
637913003783	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
637913003784	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
637913003785	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
637913003786	transcription elongation factor NusA; Provisional; Region: nusA; PRK12328
637913003787	NusA N-terminal domain; Region: NusA_N; pfam08529
637913003788	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
637913003789	RNA binding site [nucleotide binding]; other site
637913003790	homodimer interface [polypeptide binding]; other site
637913003791	NusA-like KH domain; Region: KH_5; pfam13184
637913003792	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
637913003793	G-X-X-G motif; other site
637913003794	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
637913003795	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
637913003796	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637913003797	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
637913003798	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637913003799	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
637913003800	FolB domain; Region: folB_dom; TIGR00526
637913003801	active site
637913003802	acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023
637913003803	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
637913003804	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
637913003805	NAD(P) binding pocket [chemical binding]; other site
637913003806	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
637913003807	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
637913003808	catalytic motif [active]
637913003809	Zn binding site [ion binding]; other site
637913003810	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
637913003811	RibD C-terminal domain; Region: RibD_C; cl17279
637913003812	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
637913003813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913003814	S-adenosylmethionine binding site [chemical binding]; other site
637913003815	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
637913003816	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
637913003817	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
637913003818	metal-binding site [ion binding]
637913003819	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
637913003820	Soluble P-type ATPase [General function prediction only]; Region: COG4087
637913003821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
637913003822	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003823	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
637913003824	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
637913003825	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
637913003826	Predicted permeases [General function prediction only]; Region: COG0795
637913003827	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
637913003828	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
637913003829	putative active site [active]
637913003830	catalytic residue [active]
637913003831	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
637913003832	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
637913003833	5S rRNA interface [nucleotide binding]; other site
637913003834	CTC domain interface [polypeptide binding]; other site
637913003835	L16 interface [polypeptide binding]; other site
637913003836	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
637913003837	putative active site [active]
637913003838	transaldolase; Provisional; Region: PRK03903
637913003839	catalytic residue [active]
637913003840	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
637913003841	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637913003842	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637913003843	NifU-like domain; Region: NifU; pfam01106
637913003844	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
637913003845	Phosphate transporter family; Region: PHO4; pfam01384
637913003846	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
637913003847	Domain of unknown function DUF21; Region: DUF21; pfam01595
637913003848	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
637913003849	Transporter associated domain; Region: CorC_HlyC; smart01091
637913003850	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
637913003851	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637913003852	HlyD family secretion protein; Region: HlyD_3; pfam13437
637913003853	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637913003854	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637913003855	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
637913003856	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
637913003857	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
637913003858	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
637913003859	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
637913003860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637913003861	S-adenosylmethionine binding site [chemical binding]; other site
637913003862	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14065
637913003863	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
637913003864	Predicted amidohydrolase [General function prediction only]; Region: COG0388
637913003865	active site
637913003866	catalytic triad [active]
637913003867	dimer interface [polypeptide binding]; other site
637913003868	seryl-tRNA synthetase; Provisional; Region: PRK05431
637913003869	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
637913003870	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
637913003871	dimer interface [polypeptide binding]; other site
637913003872	active site
637913003873	motif 1; other site
637913003874	motif 2; other site
637913003875	motif 3; other site
637913003876	TPR repeat; Region: TPR_11; pfam13414
637913003877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913003878	TPR motif; other site
637913003879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637913003880	binding surface
637913003881	TPR motif; other site
637913003882	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
637913003883	Part of AAA domain; Region: AAA_19; pfam13245
637913003884	Family description; Region: UvrD_C_2; pfam13538
637913003885	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515
637913003886	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
637913003887	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
637913003888	Flavoprotein; Region: Flavoprotein; pfam02441
637913003889	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
637913003890	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
637913003891	active site
637913003892	(T/H)XGH motif; other site
637913003893	thymidylate kinase; Validated; Region: tmk; PRK00698
637913003894	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
637913003895	TMP-binding site; other site
637913003896	ATP-binding site [chemical binding]; other site
637913003897	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
637913003898	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
637913003899	DNA polymerase I; Region: pola; TIGR00593
637913003900	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
637913003901	active site
637913003902	putative 5' ssDNA interaction site; other site
637913003903	metal binding site 3; metal-binding site
637913003904	metal binding site 1 [ion binding]; metal-binding site
637913003905	metal binding site 2 [ion binding]; metal-binding site
637913003906	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
637913003907	putative DNA binding site [nucleotide binding]; other site
637913003908	putative metal binding site [ion binding]; other site
637913003909	3'-5' exonuclease; Region: 35EXOc; smart00474
637913003910	active site
637913003911	substrate binding site [chemical binding]; other site
637913003912	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
637913003913	active site
637913003914	DNA binding site [nucleotide binding]
637913003915	catalytic site [active]
637913003916	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003917	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
637913003918	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
637913003919	homodimer interface [polypeptide binding]; other site
637913003920	substrate-cofactor binding pocket; other site
637913003921	catalytic residue [active]
637913003922	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003923	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
637913003924	conserved hypothetical integral membrane protein; Region: TIGR00056
637913003925	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
637913003926	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
637913003927	Walker A/P-loop; other site
637913003928	ATP binding site [chemical binding]; other site
637913003929	Q-loop/lid; other site
637913003930	ABC transporter signature motif; other site
637913003931	Walker B; other site
637913003932	D-loop; other site
637913003933	H-loop/switch region; other site
637913003934	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
637913003935	mce related protein; Region: MCE; pfam02470
637913003936	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
637913003937	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
637913003938	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
637913003939	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
637913003940	active site
637913003941	PHP Thumb interface [polypeptide binding]; other site
637913003942	metal binding site [ion binding]; metal-binding site
637913003943	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
637913003944	generic binding surface I; other site
637913003945	generic binding surface II; other site
637913003946	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
637913003947	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637913003948	RNA binding surface [nucleotide binding]; other site
637913003949	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
637913003950	active site
637913003951	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
637913003952	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637913003953	catalytic residues [active]
637913003954	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
637913003955	LPP20 lipoprotein; Region: LPP20; pfam02169
637913003956	Helicobacter outer membrane protein; Region: HP_OMP; pfam01856
637913003957	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
637913003958	tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450
637913003959	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
637913003960	GTP/Mg2+ binding site [chemical binding]; other site
637913003961	G4 box; other site
637913003962	G5 box; other site
637913003963	trmE is a tRNA modification GTPase; Region: trmE; cd04164
637913003964	G1 box; other site
637913003965	G1 box; other site
637913003966	GTP/Mg2+ binding site [chemical binding]; other site
637913003967	Switch I region; other site
637913003968	Switch I region; other site
637913003969	G2 box; other site
637913003970	G2 box; other site
637913003971	Switch II region; other site
637913003972	G3 box; other site
637913003973	G3 box; other site
637913003974	Switch II region; other site
637913003975	G4 box; other site
637913003976	G5 box; other site
637913003977	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
637913003978	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
637913003979	membrane protein insertase; Provisional; Region: PRK01318
637913003980	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
637913003981	hypothetical protein; Provisional; Region: PRK14374
637913003982	ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188
637913003983	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
637913003984	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
637913003985	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
637913003986	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
637913003987	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
637913003988	SmpB-tmRNA interface; other site
637913003989	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
637913003990	carbon storage regulator; Provisional; Region: PRK00568
637913003991	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
637913003992	active site
637913003993	Uncharacterized conserved protein [Function unknown]; Region: COG2433
637913003994	elongation factor Ts; Provisional; Region: tsf; PRK09377
637913003995	UBA/TS-N domain; Region: UBA; pfam00627
637913003996	Elongation factor TS; Region: EF_TS; pfam00889
637913003997	Elongation factor TS; Region: EF_TS; pfam00889
637913003998	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
637913003999	rRNA interaction site [nucleotide binding]; other site
637913004000	S8 interaction site; other site
637913004001	putative laminin-1 binding site; other site
637913004002	putative recombination protein RecB; Provisional; Region: PRK13909
637913004003	Family description; Region: UvrD_C_2; pfam13538
637913004004	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
637913004005	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14856
637913004006	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
637913004007	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
637913004008	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
637913004009	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
637913004010	Protein export membrane protein; Region: SecD_SecF; pfam02355
637913004011	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
637913004012	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
637913004013	HIGH motif; other site
637913004014	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
637913004015	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
637913004016	active site
637913004017	KMSKS motif; other site
637913004018	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
637913004019	tRNA binding surface [nucleotide binding]; other site
637913004020	anticodon binding site; other site
637913004021	Lipopolysaccharide-assembly; Region: LptE; pfam04390
637913004022	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
637913004023	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637913004024	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637913004025	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637913004026	Peptidase family M23; Region: Peptidase_M23; pfam01551
637913004027	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637913004028	Peptidase family M23; Region: Peptidase_M23; pfam01551
637913004029	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
637913004030	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
637913004031	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
637913004032	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
637913004033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637913004034	ATP binding site [chemical binding]; other site
637913004035	putative Mg++ binding site [ion binding]; other site
637913004036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637913004037	nucleotide binding region [chemical binding]; other site
637913004038	ATP-binding site [chemical binding]; other site
637913004039	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
637913004040	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
637913004041	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
637913004042	iron-sulfur cluster [ion binding]; other site
637913004043	[2Fe-2S] cluster binding site [ion binding]; other site
637913004044	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
637913004045	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
637913004046	intrachain domain interface; other site
637913004047	interchain domain interface [polypeptide binding]; other site
637913004048	heme bH binding site [chemical binding]; other site
637913004049	Qi binding site; other site
637913004050	heme bL binding site [chemical binding]; other site
637913004051	Qo binding site; other site
637913004052	interchain domain interface [polypeptide binding]; other site
637913004053	intrachain domain interface; other site
637913004054	Qi binding site; other site
637913004055	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
637913004056	Qo binding site; other site
637913004057	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
637913004058	Cytochrome c; Region: Cytochrom_C; pfam00034
637913004059	Cytochrome c; Region: Cytochrom_C; cl11414
637913004060	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
637913004061	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
637913004062	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
637913004063	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907
637913004064	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
637913004065	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637913004066	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
637913004067	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
637913004068	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
637913004069	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
637913004070	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
637913004071	putative ligand binding site [chemical binding]; other site
637913004072	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
637913004073	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
637913004074	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
637913004075	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
637913004076	dimer interface [polypeptide binding]; other site
637913004077	decamer (pentamer of dimers) interface [polypeptide binding]; other site
637913004078	catalytic triad [active]
637913004079	peroxidatic and resolving cysteines [active]
637913004080	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
637913004081	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
637913004082	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
637913004083	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
637913004084	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
637913004085	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
637913004086	G1 box; other site
637913004087	GTP/Mg2+ binding site [chemical binding]; other site
637913004088	Switch I region; other site
637913004089	G2 box; other site
637913004090	G3 box; other site
637913004091	Switch II region; other site
637913004092	G4 box; other site
637913004093	G5 box; other site
637913004094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
637913004095	OstA-like protein; Region: OstA; pfam03968
637913004096	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
637913004097	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
637913004098	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
637913004099	Sporulation related domain; Region: SPOR; pfam05036
637913004100	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
637913004101	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637913004102	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637913004103	catalytic residue [active]
637913004104	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
637913004105	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637913004106	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
637913004107	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
637913004108	active site
637913004109	riboflavin synthase, alpha subunit; Region: ribE; TIGR00187
637913004110	Lumazine binding domain; Region: Lum_binding; pfam00677
637913004111	Lumazine binding domain; Region: Lum_binding; pfam00677
637913004112	flhB C-terminus-related protein; Region: flhB_rel; TIGR00789
637913004113	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
637913004114	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
637913004115	Walker A/P-loop; other site
637913004116	ATP binding site [chemical binding]; other site
637913004117	Q-loop/lid; other site
637913004118	ABC transporter signature motif; other site
637913004119	Walker B; other site
637913004120	D-loop; other site
637913004121	H-loop/switch region; other site
637913004122	NIL domain; Region: NIL; pfam09383
637913004123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
637913004124	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
637913004125	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637913004126	active site
637913004127	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637913004128	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
637913004129	active site
637913004130	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
637913004131	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
637913004132	Mg++ binding site [ion binding]; other site
637913004133	putative catalytic motif [active]
637913004134	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
637913004135	active site
637913004136	hydrophilic channel; other site
637913004137	dimerization interface [polypeptide binding]; other site
637913004138	catalytic residues [active]
637913004139	active site lid [active]
637913004140	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
637913004141	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946
637913004142	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
637913004143	metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329
637913004144	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
637913004145	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637913004146	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637913004147	hypothetical protein; Provisional; Region: PRK10236
637913004148	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
637913004149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
637913004150	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
637913004151	ATP binding site [chemical binding]; other site
637913004152	substrate interface [chemical binding]; other site
637913004153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637913004154	putative substrate translocation pore; other site
637913004155	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637913004156	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
637913004157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
637913004158	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
637913004159	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409