-- dump date 20140619_114737 -- class Genbank::misc_feature -- table misc_feature_note -- id note 498761000001 PAS domain S-box; Region: sensory_box; TIGR00229 498761000002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 498761000003 putative active site [active] 498761000004 heme pocket [chemical binding]; other site 498761000005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761000006 dimer interface [polypeptide binding]; other site 498761000007 phosphorylation site [posttranslational modification] 498761000008 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498761000009 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 498761000010 ligand binding site [chemical binding]; other site 498761000011 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 498761000012 putative switch regulator; other site 498761000013 non-specific DNA interactions [nucleotide binding]; other site 498761000014 DNA binding site [nucleotide binding] 498761000015 sequence specific DNA binding site [nucleotide binding]; other site 498761000016 putative cAMP binding site [chemical binding]; other site 498761000017 Ferredoxin [Energy production and conversion]; Region: COG1146 498761000018 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498761000019 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 498761000020 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 498761000021 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 498761000022 putative uracil binding site [chemical binding]; other site 498761000023 putative active site [active] 498761000024 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000025 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000026 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000027 heat shock protein 90; Provisional; Region: PRK05218 498761000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761000029 ATP binding site [chemical binding]; other site 498761000030 Mg2+ binding site [ion binding]; other site 498761000031 G-X-G motif; other site 498761000032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761000034 Transposase; Region: HTH_Tnp_1; pfam01527 498761000035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 498761000036 Transposase; Region: DDE_Tnp_ISL3; pfam01610 498761000037 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 498761000038 TDP-binding site; other site 498761000039 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 498761000040 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000042 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000043 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761000044 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761000045 putative active site [active] 498761000046 putative NTP binding site [chemical binding]; other site 498761000047 putative nucleic acid binding site [nucleotide binding]; other site 498761000048 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761000049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000050 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 498761000051 Domain of unknown function, B. Theta Gene description (DUF3873); Region: DUF3873; pfam12989 498761000052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 498761000053 non-specific DNA binding site [nucleotide binding]; other site 498761000054 salt bridge; other site 498761000055 sequence-specific DNA binding site [nucleotide binding]; other site 498761000056 Fic family protein [Function unknown]; Region: COG3177 498761000057 Fic/DOC family; Region: Fic; pfam02661 498761000058 tape measure domain; Region: tape_meas_nterm; TIGR02675 498761000059 Protein of unknown function (DUF935); Region: DUF935; pfam06074 498761000060 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761000061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761000062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498761000063 DNA binding residues [nucleotide binding] 498761000064 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 498761000065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498761000066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761000067 sequence-specific DNA binding site [nucleotide binding]; other site 498761000068 salt bridge; other site 498761000069 integrase; Provisional; Region: int; PHA02601 498761000070 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 498761000071 Int/Topo IB signature motif; other site 498761000072 GMP synthase; Reviewed; Region: guaA; PRK00074 498761000073 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 498761000074 AMP/PPi binding site [chemical binding]; other site 498761000075 candidate oxyanion hole; other site 498761000076 catalytic triad [active] 498761000077 potential glutamine specificity residues [chemical binding]; other site 498761000078 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 498761000079 ATP Binding subdomain [chemical binding]; other site 498761000080 Ligand Binding sites [chemical binding]; other site 498761000081 Dimerization subdomain; other site 498761000082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761000083 active site 498761000084 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 498761000085 MPT binding site; other site 498761000086 trimer interface [polypeptide binding]; other site 498761000087 MOSC domain; Region: MOSC; pfam03473 498761000088 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 498761000089 trimer interface [polypeptide binding]; other site 498761000090 dimer interface [polypeptide binding]; other site 498761000091 putative active site [active] 498761000092 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 498761000093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761000094 FeS/SAM binding site; other site 498761000095 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 498761000096 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 498761000097 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 498761000098 active site 498761000099 nucleophile elbow; other site 498761000100 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 498761000101 Nitrogen regulatory protein P-II; Region: P-II; smart00938 498761000102 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 498761000103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 498761000104 active site 498761000105 phosphorylation site [posttranslational modification] 498761000106 intermolecular recognition site; other site 498761000107 dimerization interface [polypeptide binding]; other site 498761000108 ANTAR domain; Region: ANTAR; pfam03861 498761000109 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498761000110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 498761000111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498761000112 active site 498761000113 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 498761000114 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 498761000115 dimer interface [polypeptide binding]; other site 498761000116 active site 498761000117 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 498761000118 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 498761000119 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 498761000120 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 498761000121 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 498761000122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 498761000123 substrate binding site [chemical binding]; other site 498761000124 oxyanion hole (OAH) forming residues; other site 498761000125 trimer interface [polypeptide binding]; other site 498761000126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498761000127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498761000128 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 498761000129 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 498761000130 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 498761000131 acyl-activating enzyme (AAE) consensus motif; other site 498761000132 putative AMP binding site [chemical binding]; other site 498761000133 putative active site [active] 498761000134 putative CoA binding site [chemical binding]; other site 498761000135 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 498761000136 pyruvate kinase; Provisional; Region: PRK06354 498761000137 domain interfaces; other site 498761000138 active site 498761000139 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 498761000140 6-phosphofructokinase; Provisional; Region: PRK03202 498761000141 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 498761000142 active site 498761000143 ADP/pyrophosphate binding site [chemical binding]; other site 498761000144 dimerization interface [polypeptide binding]; other site 498761000145 allosteric effector site; other site 498761000146 fructose-1,6-bisphosphate binding site; other site 498761000147 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 498761000148 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 498761000149 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 498761000150 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 498761000151 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 498761000152 transcription attenuation protein MtrB; Provisional; Region: PRK13251 498761000153 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 498761000154 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 498761000155 active site 498761000156 PHP Thumb interface [polypeptide binding]; other site 498761000157 metal binding site [ion binding]; metal-binding site 498761000158 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 498761000159 generic binding surface II; other site 498761000160 generic binding surface I; other site 498761000161 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 498761000162 putative deacylase active site [active] 498761000163 FeoA domain; Region: FeoA; pfam04023 498761000164 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 498761000165 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498761000166 G1 box; other site 498761000167 GTP/Mg2+ binding site [chemical binding]; other site 498761000168 Switch I region; other site 498761000169 G2 box; other site 498761000170 G3 box; other site 498761000171 Switch II region; other site 498761000172 G4 box; other site 498761000173 G5 box; other site 498761000174 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498761000175 Nucleoside recognition; Region: Gate; pfam07670 498761000176 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 498761000177 Nucleoside recognition; Region: Gate; pfam07670 498761000178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761000179 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 498761000180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498761000181 Coenzyme A binding pocket [chemical binding]; other site 498761000182 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 498761000183 AMP-binding domain protein; Validated; Region: PRK08315 498761000184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761000185 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 498761000186 acyl-activating enzyme (AAE) consensus motif; other site 498761000187 putative AMP binding site [chemical binding]; other site 498761000188 putative active site [active] 498761000189 putative CoA binding site [chemical binding]; other site 498761000190 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 498761000191 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 498761000192 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 498761000193 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498761000194 homodimer interface [polypeptide binding]; other site 498761000195 substrate-cofactor binding pocket; other site 498761000196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761000197 catalytic residue [active] 498761000198 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 498761000199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 498761000200 VanW like protein; Region: VanW; pfam04294 498761000201 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 498761000202 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 498761000203 phosphofructokinase; Region: PFK_mixed; TIGR02483 498761000204 active site 498761000205 ADP/pyrophosphate binding site [chemical binding]; other site 498761000206 dimerization interface [polypeptide binding]; other site 498761000207 allosteric effector site; other site 498761000208 fructose-1,6-bisphosphate binding site; other site 498761000209 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 498761000210 aconitate hydratase; Validated; Region: PRK07229 498761000211 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 498761000212 substrate binding site [chemical binding]; other site 498761000213 ligand binding site [chemical binding]; other site 498761000214 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 498761000215 substrate binding site [chemical binding]; other site 498761000216 Protein of unknown function (DUF503); Region: DUF503; pfam04456 498761000217 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 498761000218 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 498761000219 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 498761000220 glycogen synthase; Provisional; Region: glgA; PRK00654 498761000221 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 498761000222 ADP-binding pocket [chemical binding]; other site 498761000223 homodimer interface [polypeptide binding]; other site 498761000224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498761000225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498761000226 Coenzyme A binding pocket [chemical binding]; other site 498761000227 endonuclease IV; Provisional; Region: PRK01060 498761000228 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 498761000229 AP (apurinic/apyrimidinic) site pocket; other site 498761000230 DNA interaction; other site 498761000231 Metal-binding active site; metal-binding site 498761000232 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 498761000233 thiamine phosphate binding site [chemical binding]; other site 498761000234 active site 498761000235 pyrophosphate binding site [ion binding]; other site 498761000236 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 498761000237 active site 498761000238 thiamine phosphate binding site [chemical binding]; other site 498761000239 pyrophosphate binding site [ion binding]; other site 498761000240 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 498761000241 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 498761000242 minor groove reading motif; other site 498761000243 helix-hairpin-helix signature motif; other site 498761000244 substrate binding pocket [chemical binding]; other site 498761000245 active site 498761000246 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 498761000247 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761000248 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 498761000249 putative ligand binding site [chemical binding]; other site 498761000250 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 498761000251 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 498761000252 Rubrerythrin [Energy production and conversion]; Region: COG1592 498761000253 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 498761000254 binuclear metal center [ion binding]; other site 498761000255 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 498761000256 iron binding site [ion binding]; other site 498761000257 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 498761000258 active site 498761000259 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 498761000260 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 498761000261 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761000262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761000263 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761000264 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761000265 catalytic residues [active] 498761000266 catalytic nucleophile [active] 498761000267 Recombinase; Region: Recombinase; pfam07508 498761000268 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761000269 Recombinase; Region: Recombinase; pfam07508 498761000270 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761000271 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761000272 catalytic residues [active] 498761000273 catalytic nucleophile [active] 498761000274 Recombinase; Region: Recombinase; pfam07508 498761000275 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761000276 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761000277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761000278 catalytic residues [active] 498761000279 catalytic nucleophile [active] 498761000280 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761000281 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498761000282 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498761000283 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498761000284 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 498761000285 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000286 Immunoglobulin domain; Region: Ig; cd00096 498761000287 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000288 Immunoglobulin domain; Region: Ig; cd00096 498761000289 Immunoglobulin domain; Region: Ig; cd00096 498761000290 Immunoglobulin domain; Region: Ig; cd00096 498761000291 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498761000292 Interdomain contacts; other site 498761000293 S-layer homology domain; Region: SLH; pfam00395 498761000294 S-layer homology domain; Region: SLH; pfam00395 498761000295 S-layer homology domain; Region: SLH; pfam00395 498761000296 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 498761000297 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 498761000298 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 498761000299 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000300 Immunoglobulin domain; Region: Ig; cd00096 498761000301 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000302 Immunoglobulin domain; Region: Ig; cd00096 498761000303 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498761000304 Interdomain contacts; other site 498761000305 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 498761000306 S-layer homology domain; Region: SLH; pfam00395 498761000307 S-layer homology domain; Region: SLH; pfam00395 498761000308 S-layer homology domain; Region: SLH; pfam00395 498761000309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000310 active site 498761000311 dimerization interface [polypeptide binding]; other site 498761000312 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000313 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000314 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000315 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000316 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000317 HYR domain; Region: HYR; pfam02494 498761000318 HYR domain; Region: HYR; pfam02494 498761000319 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 498761000320 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 498761000321 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000322 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 498761000323 S-layer homology domain; Region: SLH; pfam00395 498761000324 S-layer homology domain; Region: SLH; pfam00395 498761000325 S-layer homology domain; Region: SLH; pfam00395 498761000326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000327 active site 498761000328 dimerization interface [polypeptide binding]; other site 498761000329 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 498761000330 sugar binding site [chemical binding]; other site 498761000331 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498761000332 Interdomain contacts; other site 498761000333 S-layer homology domain; Region: SLH; pfam00395 498761000334 S-layer homology domain; Region: SLH; pfam00395 498761000335 S-layer homology domain; Region: SLH; pfam00395 498761000336 Phage Tail Collar Domain; Region: Collar; pfam07484 498761000337 Phage Tail Collar Domain; Region: Collar; pfam07484 498761000338 Phage Tail Collar Domain; Region: Collar; pfam07484 498761000339 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000340 Immunoglobulin like; Region: IG_like; smart00410 498761000341 Immunoglobulin I-set domain; Region: I-set; pfam07679 498761000342 Immunoglobulin domain; Region: Ig; cd00096 498761000343 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 498761000344 Immunoglobulin domain; Region: Ig; cd00096 498761000345 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498761000346 Interdomain contacts; other site 498761000347 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 498761000348 S-layer homology domain; Region: SLH; pfam00395 498761000349 S-layer homology domain; Region: SLH; pfam00395 498761000350 S-layer homology domain; Region: SLH; pfam00395 498761000351 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761000352 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761000353 putative active site [active] 498761000354 putative NTP binding site [chemical binding]; other site 498761000355 putative nucleic acid binding site [nucleotide binding]; other site 498761000356 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 498761000357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761000358 dimer interface [polypeptide binding]; other site 498761000359 phosphorylation site [posttranslational modification] 498761000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761000361 ATP binding site [chemical binding]; other site 498761000362 Mg2+ binding site [ion binding]; other site 498761000363 G-X-G motif; other site 498761000364 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761000365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000366 active site 498761000367 phosphorylation site [posttranslational modification] 498761000368 intermolecular recognition site; other site 498761000369 dimerization interface [polypeptide binding]; other site 498761000370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761000371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000372 active site 498761000373 phosphorylation site [posttranslational modification] 498761000374 intermolecular recognition site; other site 498761000375 dimerization interface [polypeptide binding]; other site 498761000376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761000377 DNA binding site [nucleotide binding] 498761000378 Domain of unknown function (DUF955); Region: DUF955; cl01076 498761000379 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 498761000380 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 498761000381 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 498761000382 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 498761000383 HsdM N-terminal domain; Region: HsdM_N; pfam12161 498761000384 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498761000385 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 498761000386 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 498761000387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761000388 ATP binding site [chemical binding]; other site 498761000389 putative Mg++ binding site [ion binding]; other site 498761000390 nucleotide binding region [chemical binding]; other site 498761000391 helicase superfamily c-terminal domain; Region: HELICc; smart00490 498761000392 ATP-binding site [chemical binding]; other site 498761000393 Helix-turn-helix domain; Region: HTH_17; pfam12728 498761000394 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761000395 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761000396 catalytic residues [active] 498761000397 Recombinase; Region: Recombinase; pfam07508 498761000398 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761000399 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761000400 catalytic nucleophile [active] 498761000401 Recombinase; Region: Recombinase; pfam07508 498761000402 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 498761000403 sequence-specific DNA binding site [nucleotide binding]; other site 498761000404 salt bridge; other site 498761000405 Helix-turn-helix domain; Region: HTH_36; pfam13730 498761000406 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 498761000407 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 498761000408 CHC2 zinc finger; Region: zf-CHC2; cl17510 498761000409 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 498761000410 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 498761000411 active site 498761000412 metal binding site [ion binding]; metal-binding site 498761000413 interdomain interaction site; other site 498761000414 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 498761000415 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 498761000416 Sel1-like repeats; Region: SEL1; smart00671 498761000417 Sel1-like repeats; Region: SEL1; smart00671 498761000418 Sel1-like repeats; Region: SEL1; smart00671 498761000419 DNA polymerase III subunit delta'; Validated; Region: PRK05818 498761000420 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 498761000421 Mg binding site [ion binding]; other site 498761000422 nucleotide binding site [chemical binding]; other site 498761000423 putative protofilament interface [polypeptide binding]; other site 498761000424 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761000425 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761000426 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 498761000427 putative active site pocket [active] 498761000428 dimerization interface [polypeptide binding]; other site 498761000429 putative catalytic residue [active] 498761000430 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 498761000431 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761000432 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 498761000433 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 498761000434 Int/Topo IB signature motif; other site 498761000435 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 498761000436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761000437 active site 498761000438 DNA binding site [nucleotide binding] 498761000439 Int/Topo IB signature motif; other site 498761000440 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761000441 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761000442 active site 498761000443 DNA binding site [nucleotide binding] 498761000444 Int/Topo IB signature motif; other site 498761000445 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 498761000446 AAA-like domain; Region: AAA_10; pfam12846 498761000447 Domain of unknown function DUF87; Region: DUF87; pfam01935 498761000448 Fic/DOC family; Region: Fic; cl00960 498761000449 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 498761000450 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 498761000451 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761000452 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761000453 active site 498761000454 DNA binding site [nucleotide binding] 498761000455 Int/Topo IB signature motif; other site 498761000456 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761000457 active site 498761000458 DNA binding site [nucleotide binding] 498761000459 Int/Topo IB signature motif; other site 498761000460 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 498761000461 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761000462 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761000463 active site 498761000464 DNA binding site [nucleotide binding] 498761000465 Int/Topo IB signature motif; other site 498761000466 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 498761000467 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 498761000468 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 498761000469 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498761000470 Walker A motif; other site 498761000471 ATP binding site [chemical binding]; other site 498761000472 Walker B motif; other site 498761000473 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 498761000474 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 498761000475 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 498761000476 SpoVG; Region: SpoVG; pfam04026 498761000477 YodL-like; Region: YodL; pfam14191 498761000478 S-layer homology domain; Region: SLH; pfam00395 498761000479 S-layer homology domain; Region: SLH; pfam00395 498761000480 S-layer homology domain; Region: SLH; pfam00395 498761000481 MraZ protein; Region: MraZ; pfam02381 498761000482 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 498761000483 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 498761000484 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 498761000485 Response regulator receiver domain; Region: Response_reg; pfam00072 498761000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000487 active site 498761000488 phosphorylation site [posttranslational modification] 498761000489 intermolecular recognition site; other site 498761000490 dimerization interface [polypeptide binding]; other site 498761000491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761000492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761000493 metal binding site [ion binding]; metal-binding site 498761000494 active site 498761000495 I-site; other site 498761000496 Cache domain; Region: Cache_1; pfam02743 498761000497 HAMP domain; Region: HAMP; pfam00672 498761000498 dimerization interface [polypeptide binding]; other site 498761000499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761000500 dimer interface [polypeptide binding]; other site 498761000501 phosphorylation site [posttranslational modification] 498761000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761000503 ATP binding site [chemical binding]; other site 498761000504 Mg2+ binding site [ion binding]; other site 498761000505 G-X-G motif; other site 498761000506 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000508 active site 498761000509 phosphorylation site [posttranslational modification] 498761000510 intermolecular recognition site; other site 498761000511 dimerization interface [polypeptide binding]; other site 498761000512 Response regulator receiver domain; Region: Response_reg; pfam00072 498761000513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000514 active site 498761000515 phosphorylation site [posttranslational modification] 498761000516 intermolecular recognition site; other site 498761000517 dimerization interface [polypeptide binding]; other site 498761000518 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761000519 putative binding surface; other site 498761000520 active site 498761000521 oligoendopeptidase F; Region: pepF; TIGR00181 498761000522 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 498761000523 active site 498761000524 Zn binding site [ion binding]; other site 498761000525 Cache domain; Region: Cache_1; pfam02743 498761000526 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498761000527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761000528 dimerization interface [polypeptide binding]; other site 498761000529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761000530 dimer interface [polypeptide binding]; other site 498761000531 putative CheW interface [polypeptide binding]; other site 498761000532 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 498761000533 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498761000534 DRTGG domain; Region: DRTGG; pfam07085 498761000535 CBS domain; Region: CBS; pfam00571 498761000536 DHH family; Region: DHH; pfam01368 498761000537 DHHA2 domain; Region: DHHA2; pfam02833 498761000538 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498761000539 Cation efflux family; Region: Cation_efflux; pfam01545 498761000540 S-layer homology domain; Region: SLH; pfam00395 498761000541 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 498761000542 S-layer homology domain; Region: SLH; pfam00395 498761000543 Predicted Fe-S protein [General function prediction only]; Region: COG2000 498761000544 Putative Fe-S cluster; Region: FeS; cl17515 498761000545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761000546 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761000547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761000548 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 498761000549 Walker A/P-loop; other site 498761000550 ATP binding site [chemical binding]; other site 498761000551 Q-loop/lid; other site 498761000552 ABC transporter signature motif; other site 498761000553 Walker B; other site 498761000554 D-loop; other site 498761000555 H-loop/switch region; other site 498761000556 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 498761000557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761000558 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 498761000559 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 498761000560 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 498761000561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761000562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761000563 DNA binding residues [nucleotide binding] 498761000564 Protein of unknown function DUF45; Region: DUF45; pfam01863 498761000565 LexA repressor; Validated; Region: PRK00215 498761000566 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 498761000567 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 498761000568 Catalytic site [active] 498761000569 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 498761000570 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 498761000571 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 498761000572 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 498761000573 Peptidase family U32; Region: Peptidase_U32; pfam01136 498761000574 YceG-like family; Region: YceG; pfam02618 498761000575 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 498761000576 dimerization interface [polypeptide binding]; other site 498761000577 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 498761000578 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 498761000579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 498761000580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 498761000581 active site 498761000582 catalytic tetrad [active] 498761000583 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761000584 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498761000585 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761000586 hypothetical protein; Provisional; Region: PRK05473 498761000587 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 498761000588 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 498761000589 motif 1; other site 498761000590 active site 498761000591 motif 2; other site 498761000592 motif 3; other site 498761000593 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 498761000594 DHHA1 domain; Region: DHHA1; pfam02272 498761000595 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 498761000596 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 498761000597 active site 498761000598 C-terminal domain interface [polypeptide binding]; other site 498761000599 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 498761000600 active site 498761000601 N-terminal domain interface [polypeptide binding]; other site 498761000602 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000603 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000604 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000605 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 498761000606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761000607 Zn2+ binding site [ion binding]; other site 498761000608 Mg2+ binding site [ion binding]; other site 498761000609 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 498761000610 putative transposase OrfB; Reviewed; Region: PHA02517 498761000611 HTH-like domain; Region: HTH_21; pfam13276 498761000612 Integrase core domain; Region: rve; pfam00665 498761000613 Integrase core domain; Region: rve_3; pfam13683 498761000614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761000615 Transposase; Region: HTH_Tnp_1; pfam01527 498761000616 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000618 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000619 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000621 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000622 Archaeal protein of unknown function (DUF911); Region: DUF911; pfam06023 498761000623 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl17680 498761000624 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 498761000625 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 498761000626 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 498761000627 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 498761000628 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 498761000629 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 498761000630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761000631 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 498761000632 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 498761000633 Domain of unknown function DUF77; Region: DUF77; pfam01910 498761000634 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 498761000635 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 498761000636 Ligand Binding Site [chemical binding]; other site 498761000637 Transposase domain (DUF772); Region: DUF772; pfam05598 498761000638 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761000639 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761000640 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 498761000641 AAA domain; Region: AAA_32; pfam13654 498761000642 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498761000643 Rod binding protein; Region: Rod-binding; pfam10135 498761000644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761000645 dimerization interface [polypeptide binding]; other site 498761000646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761000647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761000648 dimer interface [polypeptide binding]; other site 498761000649 putative CheW interface [polypeptide binding]; other site 498761000650 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 498761000651 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 498761000652 Walker A/P-loop; other site 498761000653 ATP binding site [chemical binding]; other site 498761000654 Q-loop/lid; other site 498761000655 ABC transporter signature motif; other site 498761000656 Walker B; other site 498761000657 D-loop; other site 498761000658 H-loop/switch region; other site 498761000659 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 498761000660 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 498761000661 Walker A/P-loop; other site 498761000662 ATP binding site [chemical binding]; other site 498761000663 Q-loop/lid; other site 498761000664 ABC transporter signature motif; other site 498761000665 Walker B; other site 498761000666 D-loop; other site 498761000667 H-loop/switch region; other site 498761000668 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 498761000669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761000670 TM-ABC transporter signature motif; other site 498761000671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761000672 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 498761000673 TM-ABC transporter signature motif; other site 498761000674 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761000675 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 498761000676 putative ligand binding site [chemical binding]; other site 498761000677 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761000678 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 498761000679 putative ligand binding site [chemical binding]; other site 498761000680 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 498761000681 active site 498761000682 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 498761000683 dimer interface [polypeptide binding]; other site 498761000684 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 498761000685 Ligand Binding Site [chemical binding]; other site 498761000686 Molecular Tunnel; other site 498761000687 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 498761000688 Protein export membrane protein; Region: SecD_SecF; cl14618 498761000689 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 498761000690 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761000691 dimer interface [polypeptide binding]; other site 498761000692 PYR/PP interface [polypeptide binding]; other site 498761000693 TPP binding site [chemical binding]; other site 498761000694 substrate binding site [chemical binding]; other site 498761000695 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 498761000696 TPP-binding site; other site 498761000697 4Fe-4S binding domain; Region: Fer4; pfam00037 498761000698 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 498761000699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761000700 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 498761000701 acyl-activating enzyme (AAE) consensus motif; other site 498761000702 AMP binding site [chemical binding]; other site 498761000703 active site 498761000704 CoA binding site [chemical binding]; other site 498761000705 Spore germination protein; Region: Spore_permease; cl17796 498761000706 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498761000707 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498761000708 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498761000709 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 498761000710 G1 box; other site 498761000711 GTP/Mg2+ binding site [chemical binding]; other site 498761000712 Switch I region; other site 498761000713 G2 box; other site 498761000714 G3 box; other site 498761000715 Switch II region; other site 498761000716 G4 box; other site 498761000717 G5 box; other site 498761000718 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 498761000719 Found in ATP-dependent protease La (LON); Region: LON; smart00464 498761000720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761000721 Walker A motif; other site 498761000722 ATP binding site [chemical binding]; other site 498761000723 Walker B motif; other site 498761000724 arginine finger; other site 498761000725 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498761000726 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 498761000727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761000728 Walker A motif; other site 498761000729 ATP binding site [chemical binding]; other site 498761000730 Walker B motif; other site 498761000731 arginine finger; other site 498761000732 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498761000733 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 498761000734 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 498761000735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761000736 Walker A motif; other site 498761000737 ATP binding site [chemical binding]; other site 498761000738 Walker B motif; other site 498761000739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 498761000740 Clp protease; Region: CLP_protease; pfam00574 498761000741 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 498761000742 oligomer interface [polypeptide binding]; other site 498761000743 active site residues [active] 498761000744 trigger factor; Provisional; Region: tig; PRK01490 498761000745 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 498761000746 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 498761000747 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 498761000748 active site 498761000749 dimerization interface [polypeptide binding]; other site 498761000750 ribonuclease PH; Reviewed; Region: rph; PRK00173 498761000751 Ribonuclease PH; Region: RNase_PH_bact; cd11362 498761000752 hexamer interface [polypeptide binding]; other site 498761000753 active site 498761000754 Fumarase C-terminus; Region: Fumerase_C; cl00795 498761000755 fumarate hydratase; Provisional; Region: PRK06246 498761000756 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498761000757 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498761000758 glutamate racemase; Provisional; Region: PRK00865 498761000759 Sporulation and spore germination; Region: Germane; pfam10646 498761000760 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 498761000761 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498761000762 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498761000763 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 498761000764 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 498761000765 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 498761000766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 498761000767 active site 498761000768 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498761000769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761000770 ATP binding site [chemical binding]; other site 498761000771 putative Mg++ binding site [ion binding]; other site 498761000772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761000773 nucleotide binding region [chemical binding]; other site 498761000774 ATP-binding site [chemical binding]; other site 498761000775 Uncharacterized conserved protein [Function unknown]; Region: COG1284 498761000776 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498761000777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498761000778 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 498761000779 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761000780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761000781 Zn2+ binding site [ion binding]; other site 498761000782 Mg2+ binding site [ion binding]; other site 498761000783 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 498761000784 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761000785 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761000786 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 498761000787 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761000788 anti sigma factor interaction site; other site 498761000789 regulatory phosphorylation site [posttranslational modification]; other site 498761000790 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 498761000791 CheC-like family; Region: CheC; pfam04509 498761000792 CheC-like family; Region: CheC; pfam04509 498761000793 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761000794 anti sigma factor interaction site; other site 498761000795 regulatory phosphorylation site [posttranslational modification]; other site 498761000796 Flagellin N-methylase; Region: FliB; cl00497 498761000797 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 498761000798 active site 498761000799 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 498761000800 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498761000801 active site 498761000802 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498761000803 Rubrerythrin [Energy production and conversion]; Region: COG1592 498761000804 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 498761000805 diiron binding motif [ion binding]; other site 498761000806 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 498761000807 Rubredoxin; Region: Rubredoxin; pfam00301 498761000808 iron binding site [ion binding]; other site 498761000809 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 498761000810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761000811 Uncharacterized conserved protein [Function unknown]; Region: COG1565 498761000812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 498761000813 E3 interaction surface; other site 498761000814 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 498761000815 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761000816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498761000817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498761000818 Walker A/P-loop; other site 498761000819 ATP binding site [chemical binding]; other site 498761000820 Q-loop/lid; other site 498761000821 ABC transporter signature motif; other site 498761000822 Walker B; other site 498761000823 D-loop; other site 498761000824 H-loop/switch region; other site 498761000825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498761000826 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498761000827 FtsX-like permease family; Region: FtsX; pfam02687 498761000828 Cytochrome c552; Region: Cytochrom_C552; pfam02335 498761000829 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 498761000830 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761000831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761000832 Zn2+ binding site [ion binding]; other site 498761000833 Mg2+ binding site [ion binding]; other site 498761000834 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 498761000835 Zn binding site [ion binding]; other site 498761000836 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 498761000837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761000838 AAA domain; Region: AAA_21; pfam13304 498761000839 Walker A/P-loop; other site 498761000840 ATP binding site [chemical binding]; other site 498761000841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761000842 Walker B; other site 498761000843 D-loop; other site 498761000844 H-loop/switch region; other site 498761000845 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 498761000846 heme-binding site [chemical binding]; other site 498761000847 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761000848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761000849 dimer interface [polypeptide binding]; other site 498761000850 putative CheW interface [polypeptide binding]; other site 498761000851 Sporulation and spore germination; Region: Germane; pfam10646 498761000852 exopolyphosphatase; Region: exo_poly_only; TIGR03706 498761000853 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 498761000854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498761000855 ligand binding site [chemical binding]; other site 498761000856 flexible hinge region; other site 498761000857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 498761000858 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 498761000859 metal binding triad; other site 498761000860 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 498761000861 active site 498761000862 catalytic site [active] 498761000863 substrate binding site [chemical binding]; other site 498761000864 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 498761000865 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 498761000866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498761000867 putative active site [active] 498761000868 putative metal binding site [ion binding]; other site 498761000869 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 498761000870 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 498761000871 malonyl-CoA binding site [chemical binding]; other site 498761000872 dimer interface [polypeptide binding]; other site 498761000873 active site 498761000874 product binding site; other site 498761000875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 498761000876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761000877 Response regulator receiver domain; Region: Response_reg; pfam00072 498761000878 active site 498761000879 phosphorylation site [posttranslational modification] 498761000880 intermolecular recognition site; other site 498761000881 dimerization interface [polypeptide binding]; other site 498761000882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761000883 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761000884 Walker A motif; other site 498761000885 ATP binding site [chemical binding]; other site 498761000886 Walker B motif; other site 498761000887 arginine finger; other site 498761000888 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498761000889 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 498761000890 Na binding site [ion binding]; other site 498761000891 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761000892 AAA domain; Region: AAA_17; pfam13207 498761000893 Asp23 family; Region: Asp23; pfam03780 498761000894 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 498761000895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 498761000896 inhibitor-cofactor binding pocket; inhibition site 498761000897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761000898 catalytic residue [active] 498761000899 AAA domain; Region: AAA_26; pfam13500 498761000900 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 498761000901 BioY family; Region: BioY; pfam02632 498761000902 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 498761000903 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 498761000904 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 498761000905 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 498761000906 RNA binding site [nucleotide binding]; other site 498761000907 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 498761000908 Acid Phosphatase; Region: Acid_PPase; cl17256 498761000909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761000910 motif II; other site 498761000911 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 498761000912 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 498761000913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498761000914 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498761000915 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 498761000916 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761000917 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761000918 putative active site [active] 498761000919 putative NTP binding site [chemical binding]; other site 498761000920 putative nucleic acid binding site [nucleotide binding]; other site 498761000921 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761000922 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498761000923 oxaloacetate decarboxylase; Provisional; Region: PRK12331 498761000924 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 498761000925 active site 498761000926 catalytic residues [active] 498761000927 metal binding site [ion binding]; metal-binding site 498761000928 homodimer binding site [polypeptide binding]; other site 498761000929 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498761000930 carboxyltransferase (CT) interaction site; other site 498761000931 biotinylation site [posttranslational modification]; other site 498761000932 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 498761000933 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 498761000934 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 498761000935 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 498761000936 B12 binding site [chemical binding]; other site 498761000937 cobalt ligand [ion binding]; other site 498761000938 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 498761000939 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 498761000940 dimer interface [polypeptide binding]; other site 498761000941 substrate binding site [chemical binding]; other site 498761000942 metal binding site [ion binding]; metal-binding site 498761000943 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 498761000944 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 498761000945 CoA binding domain; Region: CoA_binding; smart00881 498761000946 CoA-ligase; Region: Ligase_CoA; pfam00549 498761000947 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 498761000948 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 498761000949 CoA-ligase; Region: Ligase_CoA; pfam00549 498761000950 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 498761000951 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 498761000952 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761000953 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 498761000954 L-aspartate oxidase; Provisional; Region: PRK06175 498761000955 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 498761000956 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 498761000957 putative Iron-sulfur protein interface [polypeptide binding]; other site 498761000958 proximal heme binding site [chemical binding]; other site 498761000959 distal heme binding site [chemical binding]; other site 498761000960 putative dimer interface [polypeptide binding]; other site 498761000961 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 498761000962 L-lactate permease; Region: Lactate_perm; cl00701 498761000963 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 498761000964 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 498761000965 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498761000966 catalytic residues [active] 498761000967 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761000968 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 498761000969 Cysteine-rich domain; Region: CCG; pfam02754 498761000970 Cysteine-rich domain; Region: CCG; pfam02754 498761000971 FAD binding domain; Region: FAD_binding_4; pfam01565 498761000972 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 498761000973 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 498761000974 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 498761000975 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 498761000976 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761000977 Cysteine-rich domain; Region: CCG; pfam02754 498761000978 Cysteine-rich domain; Region: CCG; pfam02754 498761000979 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 498761000980 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 498761000981 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 498761000982 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 498761000983 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 498761000984 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 498761000985 TPP-binding site [chemical binding]; other site 498761000986 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 498761000987 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761000988 dimer interface [polypeptide binding]; other site 498761000989 PYR/PP interface [polypeptide binding]; other site 498761000990 TPP binding site [chemical binding]; other site 498761000991 substrate binding site [chemical binding]; other site 498761000992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498761000993 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498761000994 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761000995 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 498761000996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498761000997 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761000998 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761000999 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 498761001000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498761001001 nucleotide binding site [chemical binding]; other site 498761001002 Type III pantothenate kinase; Region: Pan_kinase; cl17198 498761001003 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 498761001004 Predicted amidohydrolase [General function prediction only]; Region: COG0388 498761001005 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 498761001006 putative active site [active] 498761001007 catalytic triad [active] 498761001008 putative dimer interface [polypeptide binding]; other site 498761001009 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 498761001010 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 498761001011 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 498761001012 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 498761001013 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 498761001014 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 498761001015 Helix-turn-helix domain; Region: HTH_17; pfam12728 498761001016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761001017 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 498761001018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761001019 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498761001020 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 498761001021 substrate binding site [chemical binding]; other site 498761001022 PBP superfamily domain; Region: PBP_like_2; pfam12849 498761001023 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 498761001024 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498761001025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761001026 Walker A/P-loop; other site 498761001027 ATP binding site [chemical binding]; other site 498761001028 Q-loop/lid; other site 498761001029 ABC transporter signature motif; other site 498761001030 Walker B; other site 498761001031 D-loop; other site 498761001032 H-loop/switch region; other site 498761001033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001034 dimer interface [polypeptide binding]; other site 498761001035 conserved gate region; other site 498761001036 putative PBP binding loops; other site 498761001037 ABC-ATPase subunit interface; other site 498761001038 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 498761001039 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498761001040 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 498761001041 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498761001042 spore coat protein YutH; Region: spore_yutH; TIGR02905 498761001043 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498761001044 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498761001045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 498761001046 Cupin domain; Region: Cupin_2; cl17218 498761001047 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 498761001048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 498761001049 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498761001050 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 498761001051 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 498761001052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761001053 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498761001054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761001055 DNA binding residues [nucleotide binding] 498761001056 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 498761001057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761001058 ATP binding site [chemical binding]; other site 498761001059 Mg2+ binding site [ion binding]; other site 498761001060 G-X-G motif; other site 498761001061 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761001062 anti sigma factor interaction site; other site 498761001063 regulatory phosphorylation site [posttranslational modification]; other site 498761001064 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 498761001065 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498761001066 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 498761001067 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 498761001068 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 498761001069 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 498761001070 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 498761001071 phosphopentomutase; Provisional; Region: PRK05362 498761001072 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 498761001073 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761001074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761001075 active site 498761001076 DNA binding site [nucleotide binding] 498761001077 Int/Topo IB signature motif; other site 498761001078 manganese transport transcriptional regulator; Provisional; Region: PRK03902 498761001079 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 498761001080 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 498761001081 Integral membrane protein DUF95; Region: DUF95; cl00572 498761001082 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 498761001083 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 498761001084 dimer interface [polypeptide binding]; other site 498761001085 ADP-ribose binding site [chemical binding]; other site 498761001086 active site 498761001087 nudix motif; other site 498761001088 metal binding site [ion binding]; metal-binding site 498761001089 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 498761001090 peptidase T-like protein; Region: PepT-like; TIGR01883 498761001091 metal binding site [ion binding]; metal-binding site 498761001092 putative dimer interface [polypeptide binding]; other site 498761001093 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 498761001094 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 498761001095 GAF domain; Region: GAF_3; pfam13492 498761001096 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761001097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001098 Zn2+ binding site [ion binding]; other site 498761001099 Mg2+ binding site [ion binding]; other site 498761001100 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 498761001101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761001102 dimerization interface [polypeptide binding]; other site 498761001103 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761001104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761001105 dimer interface [polypeptide binding]; other site 498761001106 putative CheW interface [polypeptide binding]; other site 498761001107 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 498761001108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761001109 active site 498761001110 phosphorylation site [posttranslational modification] 498761001111 intermolecular recognition site; other site 498761001112 dimerization interface [polypeptide binding]; other site 498761001113 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 498761001114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498761001115 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 498761001116 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 498761001117 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 498761001118 Walker A/P-loop; other site 498761001119 ATP binding site [chemical binding]; other site 498761001120 Q-loop/lid; other site 498761001121 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 498761001122 ABC transporter signature motif; other site 498761001123 Walker B; other site 498761001124 D-loop; other site 498761001125 H-loop/switch region; other site 498761001126 Arginine repressor [Transcription]; Region: ArgR; COG1438 498761001127 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 498761001128 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 498761001129 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498761001130 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 498761001131 ATP-NAD kinase; Region: NAD_kinase; pfam01513 498761001132 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 498761001133 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 498761001134 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761001135 RNA binding surface [nucleotide binding]; other site 498761001136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761001137 S-adenosylmethionine binding site [chemical binding]; other site 498761001138 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 498761001139 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 498761001140 TPP-binding site; other site 498761001141 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 498761001142 PYR/PP interface [polypeptide binding]; other site 498761001143 dimer interface [polypeptide binding]; other site 498761001144 TPP binding site [chemical binding]; other site 498761001145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498761001146 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 498761001147 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 498761001148 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 498761001149 phosphopeptide binding site; other site 498761001150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 498761001151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 498761001152 substrate binding pocket [chemical binding]; other site 498761001153 chain length determination region; other site 498761001154 substrate-Mg2+ binding site; other site 498761001155 catalytic residues [active] 498761001156 aspartate-rich region 1; other site 498761001157 active site lid residues [active] 498761001158 aspartate-rich region 2; other site 498761001159 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 498761001160 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 498761001161 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 498761001162 generic binding surface II; other site 498761001163 generic binding surface I; other site 498761001164 putative oxidoreductase; Provisional; Region: PRK12831 498761001165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498761001166 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 498761001167 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 498761001168 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 498761001169 FAD binding pocket [chemical binding]; other site 498761001170 FAD binding motif [chemical binding]; other site 498761001171 phosphate binding motif [ion binding]; other site 498761001172 beta-alpha-beta structure motif; other site 498761001173 NAD binding pocket [chemical binding]; other site 498761001174 Iron coordination center [ion binding]; other site 498761001175 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 498761001176 transcription antitermination factor NusB; Region: nusB; TIGR01951 498761001177 putative RNA binding site [nucleotide binding]; other site 498761001178 Asp23 family; Region: Asp23; cl00574 498761001179 Asp23 family; Region: Asp23; pfam03780 498761001180 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 498761001181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498761001182 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498761001183 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 498761001184 pyruvate carboxylase subunit B; Validated; Region: PRK09282 498761001185 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 498761001186 active site 498761001187 catalytic residues [active] 498761001188 metal binding site [ion binding]; metal-binding site 498761001189 homodimer binding site [polypeptide binding]; other site 498761001190 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498761001191 carboxyltransferase (CT) interaction site; other site 498761001192 biotinylation site [posttranslational modification]; other site 498761001193 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 498761001194 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 498761001195 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 498761001196 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 498761001197 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 498761001198 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 498761001199 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 498761001200 NTPase; Region: NTPase_1; cl17478 498761001201 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 498761001202 elongation factor P; Validated; Region: PRK00529 498761001203 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 498761001204 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 498761001205 RNA binding site [nucleotide binding]; other site 498761001206 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 498761001207 RNA binding site [nucleotide binding]; other site 498761001208 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 498761001209 Dehydroquinase class II; Region: DHquinase_II; pfam01220 498761001210 active site 498761001211 trimer interface [polypeptide binding]; other site 498761001212 dimer interface [polypeptide binding]; other site 498761001213 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498761001214 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498761001215 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 498761001216 active site 498761001217 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 498761001218 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 498761001219 Late competence development protein ComFB; Region: ComFB; pfam10719 498761001220 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 498761001221 Type II transport protein GspH; Region: GspH; pfam12019 498761001222 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 498761001223 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 498761001224 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 498761001225 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 498761001226 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 498761001227 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498761001228 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498761001229 Type II/IV secretion system protein; Region: T2SE; pfam00437 498761001230 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 498761001231 Walker A motif; other site 498761001232 ATP binding site [chemical binding]; other site 498761001233 Walker B motif; other site 498761001234 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 498761001235 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 498761001236 Pilus assembly protein, PilO; Region: PilO; cl01234 498761001237 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 498761001238 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 498761001239 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 498761001240 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 498761001241 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 498761001242 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 498761001243 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 498761001244 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498761001245 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498761001246 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 498761001247 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498761001248 Walker A motif; other site 498761001249 ATP binding site [chemical binding]; other site 498761001250 Walker B motif; other site 498761001251 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 498761001252 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 498761001253 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 498761001254 Walker A motif; other site 498761001255 ATP binding site [chemical binding]; other site 498761001256 Walker B motif; other site 498761001257 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 498761001258 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 498761001259 active site 498761001260 dimer interface [polypeptide binding]; other site 498761001261 metal binding site [ion binding]; metal-binding site 498761001262 shikimate kinase; Provisional; Region: PRK13947 498761001263 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 498761001264 ADP binding site [chemical binding]; other site 498761001265 magnesium binding site [ion binding]; other site 498761001266 putative shikimate binding site; other site 498761001267 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 498761001268 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 498761001269 Tetramer interface [polypeptide binding]; other site 498761001270 active site 498761001271 FMN-binding site [chemical binding]; other site 498761001272 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 498761001273 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 498761001274 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 498761001275 shikimate binding site; other site 498761001276 NAD(P) binding site [chemical binding]; other site 498761001277 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 498761001278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761001279 active site 498761001280 motif I; other site 498761001281 motif II; other site 498761001282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761001283 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 498761001284 active site 498761001285 dimer interface [polypeptide binding]; other site 498761001286 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 498761001287 Bacterial Ig-like domain 2; Region: BID_2; smart00635 498761001288 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 498761001289 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498761001290 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 498761001291 sporulation sigma factor SigK; Reviewed; Region: PRK05803 498761001292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761001293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761001294 DNA binding residues [nucleotide binding] 498761001295 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 498761001296 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 498761001297 polyphosphate kinase; Provisional; Region: PRK05443 498761001298 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 498761001299 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 498761001300 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 498761001301 putative domain interface [polypeptide binding]; other site 498761001302 putative active site [active] 498761001303 catalytic site [active] 498761001304 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 498761001305 putative domain interface [polypeptide binding]; other site 498761001306 putative active site [active] 498761001307 catalytic site [active] 498761001308 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 498761001309 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 498761001310 FMN binding site [chemical binding]; other site 498761001311 substrate binding site [chemical binding]; other site 498761001312 putative catalytic residue [active] 498761001313 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 498761001314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498761001315 putative substrate translocation pore; other site 498761001316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498761001317 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498761001318 carboxyltransferase (CT) interaction site; other site 498761001319 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761001320 biotinylation site [posttranslational modification]; other site 498761001321 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498761001322 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 498761001323 carboxyltransferase (CT) interaction site; other site 498761001324 biotinylation site [posttranslational modification]; other site 498761001325 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761001326 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 498761001327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 498761001328 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761001329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498761001330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498761001331 Uncharacterized conserved protein [Function unknown]; Region: COG2006 498761001332 Domain of unknown function (DUF362); Region: DUF362; pfam04015 498761001333 4Fe-4S binding domain; Region: Fer4_6; pfam12837 498761001334 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 498761001335 4Fe-4S binding domain; Region: Fer4; pfam00037 498761001336 Predicted membrane protein [Function unknown]; Region: COG2119 498761001337 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 498761001338 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 498761001339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761001340 S-adenosylmethionine binding site [chemical binding]; other site 498761001341 Putative methyltransferase; Region: Methyltransf_4; cl17290 498761001342 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 498761001343 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 498761001344 active site 498761001345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761001346 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 498761001347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001348 Zn2+ binding site [ion binding]; other site 498761001349 Mg2+ binding site [ion binding]; other site 498761001350 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761001351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001352 Zn2+ binding site [ion binding]; other site 498761001353 Mg2+ binding site [ion binding]; other site 498761001354 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 498761001355 cobalt transport protein CbiM; Validated; Region: PRK08319 498761001356 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 498761001357 cobalt transport protein CbiN; Provisional; Region: PRK02898 498761001358 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001360 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001361 Cobalt transport protein; Region: CbiQ; cl00463 498761001362 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 498761001363 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761001364 Walker A/P-loop; other site 498761001365 ATP binding site [chemical binding]; other site 498761001366 Q-loop/lid; other site 498761001367 ABC transporter signature motif; other site 498761001368 Walker B; other site 498761001369 D-loop; other site 498761001370 H-loop/switch region; other site 498761001371 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 498761001372 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 498761001373 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 498761001374 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 498761001375 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 498761001376 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 498761001377 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 498761001378 dimer interface [polypeptide binding]; other site 498761001379 substrate binding site [chemical binding]; other site 498761001380 ATP binding site [chemical binding]; other site 498761001381 thiamine monophosphate kinase; Provisional; Region: PRK05731 498761001382 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 498761001383 ATP binding site [chemical binding]; other site 498761001384 dimerization interface [polypeptide binding]; other site 498761001385 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 498761001386 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 498761001387 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761001388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001389 Zn2+ binding site [ion binding]; other site 498761001390 Mg2+ binding site [ion binding]; other site 498761001391 hydroxylamine reductase; Provisional; Region: PRK12310 498761001392 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761001393 ACS interaction site; other site 498761001394 CODH interaction site; other site 498761001395 metal cluster binding site [ion binding]; other site 498761001396 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 498761001397 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 498761001398 acyl-activating enzyme (AAE) consensus motif; other site 498761001399 putative AMP binding site [chemical binding]; other site 498761001400 putative active site [active] 498761001401 putative CoA binding site [chemical binding]; other site 498761001402 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 498761001403 CheB methylesterase; Region: CheB_methylest; pfam01339 498761001404 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 498761001405 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 498761001406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761001407 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498761001408 putative active site [active] 498761001409 heme pocket [chemical binding]; other site 498761001410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761001411 dimer interface [polypeptide binding]; other site 498761001412 phosphorylation site [posttranslational modification] 498761001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761001414 ATP binding site [chemical binding]; other site 498761001415 Mg2+ binding site [ion binding]; other site 498761001416 G-X-G motif; other site 498761001417 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761001418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761001419 active site 498761001420 phosphorylation site [posttranslational modification] 498761001421 intermolecular recognition site; other site 498761001422 dimerization interface [polypeptide binding]; other site 498761001423 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761001424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001425 Zn2+ binding site [ion binding]; other site 498761001426 Mg2+ binding site [ion binding]; other site 498761001427 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 498761001428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498761001429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498761001430 substrate binding pocket [chemical binding]; other site 498761001431 membrane-bound complex binding site; other site 498761001432 hinge residues; other site 498761001433 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 498761001434 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 498761001435 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 498761001436 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 498761001437 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 498761001438 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 498761001439 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 498761001440 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 498761001441 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 498761001442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761001443 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001445 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001446 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 498761001447 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 498761001448 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 498761001449 ParA/MinD ATPase like; Region: ParA; pfam10609 498761001450 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498761001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001452 dimer interface [polypeptide binding]; other site 498761001453 conserved gate region; other site 498761001454 putative PBP binding loops; other site 498761001455 ABC-ATPase subunit interface; other site 498761001456 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498761001457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001458 dimer interface [polypeptide binding]; other site 498761001459 conserved gate region; other site 498761001460 putative PBP binding loops; other site 498761001461 ABC-ATPase subunit interface; other site 498761001462 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761001463 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761001464 putative active site [active] 498761001465 putative NTP binding site [chemical binding]; other site 498761001466 putative nucleic acid binding site [nucleotide binding]; other site 498761001467 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761001468 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498761001469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498761001470 substrate binding pocket [chemical binding]; other site 498761001471 membrane-bound complex binding site; other site 498761001472 hinge residues; other site 498761001473 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 498761001474 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 498761001475 Walker A/P-loop; other site 498761001476 ATP binding site [chemical binding]; other site 498761001477 Q-loop/lid; other site 498761001478 ABC transporter signature motif; other site 498761001479 Walker B; other site 498761001480 D-loop; other site 498761001481 H-loop/switch region; other site 498761001482 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761001483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761001484 Zn2+ binding site [ion binding]; other site 498761001485 Mg2+ binding site [ion binding]; other site 498761001486 FOG: CBS domain [General function prediction only]; Region: COG0517 498761001487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 498761001488 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 498761001489 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 498761001490 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 498761001491 Cache domain; Region: Cache_1; pfam02743 498761001492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761001493 dimerization interface [polypeptide binding]; other site 498761001494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761001495 dimer interface [polypeptide binding]; other site 498761001496 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498761001497 putative CheW interface [polypeptide binding]; other site 498761001498 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 498761001499 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498761001500 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498761001501 VanW like protein; Region: VanW; pfam04294 498761001502 Winged helix-turn helix; Region: HTH_29; pfam13551 498761001503 Helix-turn-helix domain; Region: HTH_28; pfam13518 498761001504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 498761001505 Integrase core domain; Region: rve; pfam00665 498761001506 Integrase core domain; Region: rve_3; cl15866 498761001507 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 498761001508 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 498761001509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761001510 Walker A motif; other site 498761001511 ATP binding site [chemical binding]; other site 498761001512 Walker B motif; other site 498761001513 arginine finger; other site 498761001514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761001515 Transposase; Region: HTH_Tnp_1; pfam01527 498761001516 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001518 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001519 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001520 putative transposase OrfB; Reviewed; Region: PHA02517 498761001521 HTH-like domain; Region: HTH_21; pfam13276 498761001522 Integrase core domain; Region: rve; pfam00665 498761001523 Integrase core domain; Region: rve_3; pfam13683 498761001524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761001525 Transposase; Region: HTH_Tnp_1; pfam01527 498761001526 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001528 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001531 HerA helicase [Replication, recombination, and repair]; Region: COG0433 498761001532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 498761001533 ATP binding site [chemical binding]; other site 498761001534 Mg2+ binding site [ion binding]; other site 498761001535 G-X-G motif; other site 498761001536 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 498761001537 B12 binding site [chemical binding]; other site 498761001538 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498761001539 aspartate aminotransferase; Provisional; Region: PRK05764 498761001540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761001542 homodimer interface [polypeptide binding]; other site 498761001543 catalytic residue [active] 498761001544 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 498761001545 CotJB protein; Region: CotJB; pfam12652 498761001546 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 498761001547 dimanganese center [ion binding]; other site 498761001548 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 498761001549 SmpB-tmRNA interface; other site 498761001550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 498761001551 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 498761001552 CoenzymeA binding site [chemical binding]; other site 498761001553 subunit interaction site [polypeptide binding]; other site 498761001554 PHB binding site; other site 498761001555 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 498761001556 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 498761001557 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 498761001558 enolase; Provisional; Region: eno; PRK00077 498761001559 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 498761001560 dimer interface [polypeptide binding]; other site 498761001561 metal binding site [ion binding]; metal-binding site 498761001562 substrate binding pocket [chemical binding]; other site 498761001563 phosphoglyceromutase; Provisional; Region: PRK05434 498761001564 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 498761001565 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001567 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001568 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 498761001569 triosephosphate isomerase; Provisional; Region: PRK14565 498761001570 substrate binding site [chemical binding]; other site 498761001571 dimer interface [polypeptide binding]; other site 498761001572 catalytic triad [active] 498761001573 Phosphoglycerate kinase; Region: PGK; pfam00162 498761001574 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 498761001575 substrate binding site [chemical binding]; other site 498761001576 hinge regions; other site 498761001577 ADP binding site [chemical binding]; other site 498761001578 catalytic site [active] 498761001579 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 498761001580 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 498761001581 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 498761001582 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 498761001583 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 498761001584 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 498761001585 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 498761001586 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 498761001587 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 498761001588 trimer interface [polypeptide binding]; other site 498761001589 active site 498761001590 substrate binding site [chemical binding]; other site 498761001591 CoA binding site [chemical binding]; other site 498761001592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 498761001593 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 498761001594 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 498761001595 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 498761001596 phosphate binding site [ion binding]; other site 498761001597 putative substrate binding pocket [chemical binding]; other site 498761001598 dimer interface [polypeptide binding]; other site 498761001599 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 498761001600 AAA domain; Region: AAA_33; pfam13671 498761001601 4-alpha-glucanotransferase; Provisional; Region: PRK14508 498761001602 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 498761001603 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 498761001604 active site 498761001605 catalytic site [active] 498761001606 Membrane protein of unknown function; Region: DUF360; pfam04020 498761001607 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 498761001608 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 498761001609 GIY-YIG motif/motif A; other site 498761001610 active site 498761001611 catalytic site [active] 498761001612 putative DNA binding site [nucleotide binding]; other site 498761001613 metal binding site [ion binding]; metal-binding site 498761001614 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 498761001615 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 498761001616 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 498761001617 active site 498761001618 dimer interface [polypeptide binding]; other site 498761001619 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 498761001620 dimer interface [polypeptide binding]; other site 498761001621 active site 498761001622 Divergent PAP2 family; Region: DUF212; cl00855 498761001623 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 498761001624 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 498761001625 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 498761001626 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 498761001627 YmaF family; Region: YmaF; pfam12788 498761001628 excinuclease ABC subunit B; Provisional; Region: PRK05298 498761001629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761001630 ATP binding site [chemical binding]; other site 498761001631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761001632 nucleotide binding region [chemical binding]; other site 498761001633 ATP-binding site [chemical binding]; other site 498761001634 Ultra-violet resistance protein B; Region: UvrB; pfam12344 498761001635 UvrB/uvrC motif; Region: UVR; pfam02151 498761001636 sensor protein ZraS; Provisional; Region: PRK10364 498761001637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761001638 dimer interface [polypeptide binding]; other site 498761001639 phosphorylation site [posttranslational modification] 498761001640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761001641 ATP binding site [chemical binding]; other site 498761001642 G-X-G motif; other site 498761001643 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 498761001644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761001645 active site 498761001646 phosphorylation site [posttranslational modification] 498761001647 intermolecular recognition site; other site 498761001648 dimerization interface [polypeptide binding]; other site 498761001649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761001650 Walker A motif; other site 498761001651 ATP binding site [chemical binding]; other site 498761001652 Walker B motif; other site 498761001653 arginine finger; other site 498761001654 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498761001655 4Fe-4S binding domain; Region: Fer4_5; pfam12801 498761001656 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761001657 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 498761001658 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 498761001659 Sodium Bile acid symporter family; Region: SBF; cl17470 498761001660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498761001661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761001662 non-specific DNA binding site [nucleotide binding]; other site 498761001663 salt bridge; other site 498761001664 sequence-specific DNA binding site [nucleotide binding]; other site 498761001665 Domain of unknown function (DUF955); Region: DUF955; pfam06114 498761001666 S-layer homology domain; Region: SLH; pfam00395 498761001667 S-layer homology domain; Region: SLH; pfam00395 498761001668 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 498761001669 Dynamin family; Region: Dynamin_N; pfam00350 498761001670 G1 box; other site 498761001671 GTP/Mg2+ binding site [chemical binding]; other site 498761001672 G2 box; other site 498761001673 Switch I region; other site 498761001674 G3 box; other site 498761001675 Switch II region; other site 498761001676 G4 box; other site 498761001677 G5 box; other site 498761001678 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 498761001679 Dynamin family; Region: Dynamin_N; pfam00350 498761001680 G1 box; other site 498761001681 GTP/Mg2+ binding site [chemical binding]; other site 498761001682 G2 box; other site 498761001683 Switch I region; other site 498761001684 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 498761001685 G2 box; other site 498761001686 G3 box; other site 498761001687 Switch II region; other site 498761001688 GTP/Mg2+ binding site [chemical binding]; other site 498761001689 G4 box; other site 498761001690 G5 box; other site 498761001691 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 498761001692 heme-binding site [chemical binding]; other site 498761001693 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761001694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761001695 dimer interface [polypeptide binding]; other site 498761001696 putative CheW interface [polypeptide binding]; other site 498761001697 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 498761001698 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 498761001699 CoA binding domain; Region: CoA_binding; pfam02629 498761001700 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498761001701 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 498761001702 C-terminal peptidase (prc); Region: prc; TIGR00225 498761001703 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 498761001704 protein binding site [polypeptide binding]; other site 498761001705 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 498761001706 Catalytic dyad [active] 498761001707 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761001708 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761001709 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 498761001710 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 498761001711 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 498761001712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761001713 Walker A/P-loop; other site 498761001714 ATP binding site [chemical binding]; other site 498761001715 Q-loop/lid; other site 498761001716 ABC transporter signature motif; other site 498761001717 Walker B; other site 498761001718 D-loop; other site 498761001719 H-loop/switch region; other site 498761001720 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 498761001721 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 498761001722 PYR/PP interface [polypeptide binding]; other site 498761001723 dimer interface [polypeptide binding]; other site 498761001724 TPP binding site [chemical binding]; other site 498761001725 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498761001726 transketolase; Reviewed; Region: PRK05899 498761001727 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 498761001728 TPP-binding site [chemical binding]; other site 498761001729 dimer interface [polypeptide binding]; other site 498761001730 peptide chain release factor 2; Provisional; Region: PRK05589 498761001731 PCRF domain; Region: PCRF; pfam03462 498761001732 RF-1 domain; Region: RF-1; pfam00472 498761001733 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 498761001734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761001735 ATP binding site [chemical binding]; other site 498761001736 putative Mg++ binding site [ion binding]; other site 498761001737 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 498761001738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 498761001739 nucleotide binding region [chemical binding]; other site 498761001740 ATP-binding site [chemical binding]; other site 498761001741 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 498761001742 30S subunit binding site; other site 498761001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 498761001744 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 498761001745 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 498761001746 Walker A/P-loop; other site 498761001747 ATP binding site [chemical binding]; other site 498761001748 Q-loop/lid; other site 498761001749 ABC transporter signature motif; other site 498761001750 Walker B; other site 498761001751 D-loop; other site 498761001752 H-loop/switch region; other site 498761001753 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498761001754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001755 dimer interface [polypeptide binding]; other site 498761001756 conserved gate region; other site 498761001757 putative PBP binding loops; other site 498761001758 ABC-ATPase subunit interface; other site 498761001759 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498761001760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498761001761 substrate binding pocket [chemical binding]; other site 498761001762 membrane-bound complex binding site; other site 498761001763 hinge residues; other site 498761001764 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 498761001765 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761001766 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 498761001767 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 498761001768 inhibitor-cofactor binding pocket; inhibition site 498761001769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761001770 catalytic residue [active] 498761001771 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 498761001772 ligand binding site; other site 498761001773 TRAM domain; Region: TRAM; cl01282 498761001774 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 498761001775 Protein of unknown function (DUF327); Region: DUF327; pfam03885 498761001776 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 498761001777 Flagellar protein FliS; Region: FliS; cl00654 498761001778 flagellin; Reviewed; Region: PRK08869 498761001779 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498761001780 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498761001781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498761001782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498761001783 NAD(P) binding site [chemical binding]; other site 498761001784 active site 498761001785 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 498761001786 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 498761001787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761001788 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 498761001789 acyl-activating enzyme (AAE) consensus motif; other site 498761001790 acyl-activating enzyme (AAE) consensus motif; other site 498761001791 active site 498761001792 AMP binding site [chemical binding]; other site 498761001793 CoA binding site [chemical binding]; other site 498761001794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 498761001795 classical (c) SDRs; Region: SDR_c; cd05233 498761001796 NAD(P) binding site [chemical binding]; other site 498761001797 active site 498761001798 pseudaminic acid synthase; Region: PseI; TIGR03586 498761001799 NeuB family; Region: NeuB; pfam03102 498761001800 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 498761001801 NeuB binding interface [polypeptide binding]; other site 498761001802 putative substrate binding site [chemical binding]; other site 498761001803 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 498761001804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498761001805 UDP-galactopyranose mutase; Region: GLF; pfam03275 498761001806 phosphomannomutase CpsG; Provisional; Region: PRK15414 498761001807 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 498761001808 active site 498761001809 substrate binding site [chemical binding]; other site 498761001810 metal binding site [ion binding]; metal-binding site 498761001811 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 498761001812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 498761001813 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001814 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001815 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001816 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 498761001817 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 498761001818 Probable Catalytic site; other site 498761001819 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 498761001820 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 498761001821 Substrate binding site; other site 498761001822 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 498761001823 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 498761001824 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 498761001825 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 498761001826 Probable Catalytic site; other site 498761001827 metal-binding site 498761001828 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 498761001829 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001830 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001831 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001832 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 498761001833 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 498761001834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761001835 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 498761001836 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 498761001837 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 498761001838 metal-binding site 498761001839 Methyltransferase domain; Region: Methyltransf_23; pfam13489 498761001840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761001841 S-adenosylmethionine binding site [chemical binding]; other site 498761001842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001843 Integrase core domain; Region: rve_3; pfam13683 498761001844 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 498761001845 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 498761001846 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 498761001847 NAD(P) binding site [chemical binding]; other site 498761001848 homodimer interface [polypeptide binding]; other site 498761001849 substrate binding site [chemical binding]; other site 498761001850 active site 498761001851 FlaG protein; Region: FlaG; cl00591 498761001852 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 498761001853 Flagellar protein FliS; Region: FliS; cl00654 498761001854 flagellar capping protein; Validated; Region: fliD; PRK07737 498761001855 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 498761001856 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 498761001857 flagellin; Reviewed; Region: PRK08869 498761001858 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498761001859 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498761001860 Global regulator protein family; Region: CsrA; pfam02599 498761001861 flagellar assembly protein FliW; Provisional; Region: PRK13285 498761001862 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 498761001863 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498761001864 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498761001865 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 498761001866 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498761001867 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498761001868 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498761001869 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 498761001870 FlgN protein; Region: FlgN; pfam05130 498761001871 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 498761001872 flagellar operon protein TIGR03826; Region: YvyF 498761001873 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 498761001874 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761001875 active site 498761001876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761001877 ATP binding site [chemical binding]; other site 498761001878 putative Mg++ binding site [ion binding]; other site 498761001879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761001880 nucleotide binding region [chemical binding]; other site 498761001881 ATP-binding site [chemical binding]; other site 498761001882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 498761001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761001884 active site 498761001885 phosphorylation site [posttranslational modification] 498761001886 intermolecular recognition site; other site 498761001887 dimerization interface [polypeptide binding]; other site 498761001888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 498761001889 DNA binding residues [nucleotide binding] 498761001890 dimerization interface [polypeptide binding]; other site 498761001891 Sensor protein DegS; Region: DegS; pfam05384 498761001892 Histidine kinase; Region: HisKA_3; pfam07730 498761001893 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 498761001894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761001895 ATP binding site [chemical binding]; other site 498761001896 Mg2+ binding site [ion binding]; other site 498761001897 G-X-G motif; other site 498761001898 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 498761001899 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 498761001900 active site 498761001901 substrate binding site [chemical binding]; other site 498761001902 metal binding site [ion binding]; metal-binding site 498761001903 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498761001904 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 498761001905 NAD binding site [chemical binding]; other site 498761001906 substrate binding site [chemical binding]; other site 498761001907 homodimer interface [polypeptide binding]; other site 498761001908 active site 498761001909 Bacterial SH3 domain; Region: SH3_3; pfam08239 498761001910 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 498761001911 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 498761001912 Mg++ binding site [ion binding]; other site 498761001913 putative catalytic motif [active] 498761001914 substrate binding site [chemical binding]; other site 498761001915 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 498761001916 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 498761001917 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761001918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 498761001919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761001920 putative homodimer interface [polypeptide binding]; other site 498761001921 O-Antigen ligase; Region: Wzy_C; cl04850 498761001922 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 498761001923 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 498761001924 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 498761001925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761001926 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 498761001927 putative ADP-binding pocket [chemical binding]; other site 498761001928 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 498761001929 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 498761001930 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 498761001931 Ligand binding site; other site 498761001932 Putative Catalytic site; other site 498761001933 DXD motif; other site 498761001934 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 498761001935 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 498761001936 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 498761001937 NADP binding site [chemical binding]; other site 498761001938 active site 498761001939 putative substrate binding site [chemical binding]; other site 498761001940 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 498761001941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761001942 Walker A/P-loop; other site 498761001943 ATP binding site [chemical binding]; other site 498761001944 Q-loop/lid; other site 498761001945 ABC transporter signature motif; other site 498761001946 Walker B; other site 498761001947 D-loop; other site 498761001948 H-loop/switch region; other site 498761001949 TOBE domain; Region: TOBE; cl01440 498761001950 Rrf2 family protein; Region: rrf2_super; TIGR00738 498761001951 Transcriptional regulator; Region: Rrf2; pfam02082 498761001952 sulfate transport protein; Provisional; Region: cysT; CHL00187 498761001953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001954 dimer interface [polypeptide binding]; other site 498761001955 conserved gate region; other site 498761001956 putative PBP binding loops; other site 498761001957 ABC-ATPase subunit interface; other site 498761001958 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 498761001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761001960 dimer interface [polypeptide binding]; other site 498761001961 conserved gate region; other site 498761001962 putative PBP binding loops; other site 498761001963 ABC-ATPase subunit interface; other site 498761001964 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498761001965 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 498761001966 Transposase domain (DUF772); Region: DUF772; pfam05598 498761001967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761001968 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761001969 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 498761001970 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 498761001971 CysD dimerization site [polypeptide binding]; other site 498761001972 G1 box; other site 498761001973 putative GEF interaction site [polypeptide binding]; other site 498761001974 GTP/Mg2+ binding site [chemical binding]; other site 498761001975 Switch I region; other site 498761001976 G2 box; other site 498761001977 G3 box; other site 498761001978 Switch II region; other site 498761001979 G4 box; other site 498761001980 G5 box; other site 498761001981 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 498761001982 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 498761001983 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 498761001984 ligand-binding site [chemical binding]; other site 498761001985 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 498761001986 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 498761001987 Active Sites [active] 498761001988 Predicted dehydrogenase [General function prediction only]; Region: COG0579 498761001989 hydroxyglutarate oxidase; Provisional; Region: PRK11728 498761001990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761001991 binding surface 498761001992 TPR motif; other site 498761001993 TPR repeat; Region: TPR_11; pfam13414 498761001994 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 498761001995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761001996 Transposase; Region: HTH_Tnp_1; pfam01527 498761001997 Winged helix-turn helix; Region: HTH_29; pfam13551 498761001998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 498761001999 Winged helix-turn helix; Region: HTH_29; pfam13551 498761002000 Homeodomain-like domain; Region: HTH_32; pfam13565 498761002001 Integrase core domain; Region: rve; pfam00665 498761002002 Integrase core domain; Region: rve_3; pfam13683 498761002003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761002004 Transposase; Region: HTH_Tnp_1; pfam01527 498761002005 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 498761002006 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 498761002007 Substrate binding site; other site 498761002008 Mg++ binding site; other site 498761002009 metal-binding site 498761002010 Mg++ binding site; other site 498761002011 metal-binding site 498761002012 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 498761002013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761002014 active site 498761002015 motif I; other site 498761002016 motif II; other site 498761002017 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761002018 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 498761002019 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 498761002020 dimer interface [polypeptide binding]; other site 498761002021 active site 498761002022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498761002023 extended (e) SDRs; Region: SDR_e; cd08946 498761002024 NAD(P) binding site [chemical binding]; other site 498761002025 active site 498761002026 substrate binding site [chemical binding]; other site 498761002027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761002028 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 498761002029 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 498761002030 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 498761002031 Transposase domain (DUF772); Region: DUF772; pfam05598 498761002032 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761002033 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 498761002034 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 498761002035 Walker A/P-loop; other site 498761002036 ATP binding site [chemical binding]; other site 498761002037 Q-loop/lid; other site 498761002038 ABC transporter signature motif; other site 498761002039 Walker B; other site 498761002040 D-loop; other site 498761002041 H-loop/switch region; other site 498761002042 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 498761002043 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498761002044 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 498761002045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498761002046 NAD(P) binding site [chemical binding]; other site 498761002047 active site 498761002048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498761002049 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 498761002050 NAD(P) binding site [chemical binding]; other site 498761002051 active site 498761002052 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 498761002053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761002054 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 498761002055 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 498761002056 putative ADP-binding pocket [chemical binding]; other site 498761002057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761002058 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 498761002059 Bacterial sugar transferase; Region: Bac_transf; pfam02397 498761002060 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002061 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 498761002062 Sel1 repeat; Region: Sel1; cl02723 498761002063 Sel1-like repeats; Region: SEL1; smart00671 498761002064 Sel1-like repeats; Region: SEL1; smart00671 498761002065 Sel1-like repeats; Region: SEL1; smart00671 498761002066 O-Antigen ligase; Region: Wzy_C; cl04850 498761002067 O-Antigen ligase; Region: Wzy_C; pfam04932 498761002068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498761002069 TPR motif; other site 498761002070 binding surface 498761002071 SeqA protein; Region: SeqA; cl11470 498761002072 Outer membrane efflux protein; Region: OEP; pfam02321 498761002073 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002074 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002075 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002076 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002077 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761002078 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761002079 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761002080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761002081 DNA binding residues [nucleotide binding] 498761002082 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 498761002083 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 498761002084 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 498761002085 active site 498761002086 catalytic triad [active] 498761002087 S-layer homology domain; Region: SLH; pfam00395 498761002088 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 498761002089 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 498761002090 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 498761002091 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 498761002092 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 498761002093 S-layer homology domain; Region: SLH; pfam00395 498761002094 S-layer homology domain; Region: SLH; pfam00395 498761002095 S-layer homology domain; Region: SLH; pfam00395 498761002096 S-layer homology domain; Region: SLH; pfam00395 498761002097 S-layer homology domain; Region: SLH; pfam00395 498761002098 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 498761002099 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 498761002100 IPT/TIG domain; Region: TIG; pfam01833 498761002101 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 498761002102 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 498761002103 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498761002104 Interdomain contacts; other site 498761002105 Cytokine receptor motif; other site 498761002106 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 498761002107 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498761002108 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 498761002109 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498761002110 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 498761002111 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 498761002112 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 498761002113 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 498761002114 active site 498761002115 tetramer interface; other site 498761002116 rod shape-determining protein Mbl; Provisional; Region: PRK13928 498761002117 MreB and similar proteins; Region: MreB_like; cd10225 498761002118 nucleotide binding site [chemical binding]; other site 498761002119 Mg binding site [ion binding]; other site 498761002120 putative protofilament interaction site [polypeptide binding]; other site 498761002121 RodZ interaction site [polypeptide binding]; other site 498761002122 Stage III sporulation protein D; Region: SpoIIID; pfam12116 498761002123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761002124 Stage II sporulation protein; Region: SpoIID; pfam08486 498761002125 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 498761002126 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 498761002127 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 498761002128 hinge; other site 498761002129 active site 498761002130 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 498761002131 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 498761002132 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 498761002133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761002134 FeS/SAM binding site; other site 498761002135 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 498761002136 gamma subunit interface [polypeptide binding]; other site 498761002137 epsilon subunit interface [polypeptide binding]; other site 498761002138 LBP interface [polypeptide binding]; other site 498761002139 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 498761002140 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498761002141 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 498761002142 alpha subunit interaction interface [polypeptide binding]; other site 498761002143 Walker A motif; other site 498761002144 ATP binding site [chemical binding]; other site 498761002145 Walker B motif; other site 498761002146 inhibitor binding site; inhibition site 498761002147 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498761002148 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 498761002149 core domain interface [polypeptide binding]; other site 498761002150 delta subunit interface [polypeptide binding]; other site 498761002151 epsilon subunit interface [polypeptide binding]; other site 498761002152 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 498761002153 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498761002154 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 498761002155 beta subunit interaction interface [polypeptide binding]; other site 498761002156 Walker A motif; other site 498761002157 ATP binding site [chemical binding]; other site 498761002158 Walker B motif; other site 498761002159 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498761002160 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 498761002161 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 498761002162 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 498761002163 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 498761002164 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 498761002165 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 498761002166 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 498761002167 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 498761002168 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 498761002169 active site 498761002170 homodimer interface [polypeptide binding]; other site 498761002171 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 498761002172 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 498761002173 catalytic motif [active] 498761002174 Zn binding site [ion binding]; other site 498761002175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761002176 active site 498761002177 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 498761002178 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 498761002179 dimer interface [polypeptide binding]; other site 498761002180 active site 498761002181 glycine-pyridoxal phosphate binding site [chemical binding]; other site 498761002182 folate binding site [chemical binding]; other site 498761002183 hypothetical protein; Provisional; Region: PRK13690 498761002184 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 498761002185 Low molecular weight phosphatase family; Region: LMWPc; cd00115 498761002186 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 498761002187 active site 498761002188 Domain of unknown function DUF; Region: DUF204; pfam02659 498761002189 Domain of unknown function DUF; Region: DUF204; pfam02659 498761002190 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 498761002191 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 498761002192 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 498761002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761002194 S-adenosylmethionine binding site [chemical binding]; other site 498761002195 peptide chain release factor 1; Validated; Region: prfA; PRK00591 498761002196 This domain is found in peptide chain release factors; Region: PCRF; smart00937 498761002197 RF-1 domain; Region: RF-1; pfam00472 498761002198 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 498761002199 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 498761002200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761002201 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 498761002202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761002203 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761002204 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 498761002205 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 498761002206 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 498761002207 putative active site [active] 498761002208 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 498761002209 active site 498761002210 intersubunit interactions; other site 498761002211 catalytic residue [active] 498761002212 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 498761002213 intersubunit interface [polypeptide binding]; other site 498761002214 active site 498761002215 zinc binding site [ion binding]; other site 498761002216 Na+ binding site [ion binding]; other site 498761002217 Response regulator receiver domain; Region: Response_reg; pfam00072 498761002218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761002219 active site 498761002220 phosphorylation site [posttranslational modification] 498761002221 intermolecular recognition site; other site 498761002222 dimerization interface [polypeptide binding]; other site 498761002223 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 498761002224 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 498761002225 tandem repeat interface [polypeptide binding]; other site 498761002226 oligomer interface [polypeptide binding]; other site 498761002227 active site residues [active] 498761002228 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 498761002229 active site 498761002230 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498761002231 dimer interface [polypeptide binding]; other site 498761002232 substrate binding site [chemical binding]; other site 498761002233 catalytic residues [active] 498761002234 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 498761002235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 498761002236 CTP synthetase; Validated; Region: pyrG; PRK05380 498761002237 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 498761002238 Catalytic site [active] 498761002239 active site 498761002240 UTP binding site [chemical binding]; other site 498761002241 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 498761002242 active site 498761002243 putative oxyanion hole; other site 498761002244 catalytic triad [active] 498761002245 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 498761002246 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 498761002247 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 498761002248 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 498761002249 active site 498761002250 HIGH motif; other site 498761002251 KMSK motif region; other site 498761002252 tRNA binding surface [nucleotide binding]; other site 498761002253 DALR anticodon binding domain; Region: DALR_1; smart00836 498761002254 anticodon binding site; other site 498761002255 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 498761002256 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498761002257 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498761002258 ligand binding site [chemical binding]; other site 498761002259 flexible hinge region; other site 498761002260 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 498761002261 putative switch regulator; other site 498761002262 non-specific DNA interactions [nucleotide binding]; other site 498761002263 DNA binding site [nucleotide binding] 498761002264 sequence specific DNA binding site [nucleotide binding]; other site 498761002265 putative cAMP binding site [chemical binding]; other site 498761002266 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 498761002267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761002268 putative CheW interface [polypeptide binding]; other site 498761002269 Cache domain; Region: Cache_1; pfam02743 498761002270 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761002271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761002272 active site 498761002273 phosphorylation site [posttranslational modification] 498761002274 intermolecular recognition site; other site 498761002275 dimerization interface [polypeptide binding]; other site 498761002276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761002277 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 498761002278 putative active site [active] 498761002279 heme pocket [chemical binding]; other site 498761002280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761002281 dimer interface [polypeptide binding]; other site 498761002282 phosphorylation site [posttranslational modification] 498761002283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761002284 ATP binding site [chemical binding]; other site 498761002285 Mg2+ binding site [ion binding]; other site 498761002286 G-X-G motif; other site 498761002287 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 498761002288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498761002289 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 498761002290 putative dimerization interface [polypeptide binding]; other site 498761002291 Predicted membrane protein [Function unknown]; Region: COG2855 498761002292 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 498761002293 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 498761002294 NAD binding site [chemical binding]; other site 498761002295 homodimer interface [polypeptide binding]; other site 498761002296 active site 498761002297 substrate binding site [chemical binding]; other site 498761002298 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 498761002299 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 498761002300 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498761002301 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 498761002302 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 498761002303 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 498761002304 stage V sporulation protein AD; Provisional; Region: PRK12404 498761002305 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 498761002306 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 498761002307 Predicted membrane protein [Function unknown]; Region: COG2323 498761002308 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 498761002309 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 498761002310 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 498761002311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761002312 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 498761002313 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 498761002314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002315 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 498761002316 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 498761002317 active site 498761002318 dimer interface [polypeptide binding]; other site 498761002319 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 498761002320 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 498761002321 active site 498761002322 FMN binding site [chemical binding]; other site 498761002323 substrate binding site [chemical binding]; other site 498761002324 3Fe-4S cluster binding site [ion binding]; other site 498761002325 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 498761002326 domain interface; other site 498761002327 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 498761002328 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 498761002329 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 498761002330 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 498761002331 DNA binding site [nucleotide binding] 498761002332 active site 498761002333 histidinol-phosphatase; Provisional; Region: PRK05588 498761002334 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 498761002335 active site 498761002336 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 498761002337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761002338 S-adenosylmethionine binding site [chemical binding]; other site 498761002339 Uncharacterized conserved protein [Function unknown]; Region: COG3270 498761002340 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 498761002341 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 498761002342 putative active site [active] 498761002343 putative metal binding site [ion binding]; other site 498761002344 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498761002345 catalytic loop [active] 498761002346 iron binding site [ion binding]; other site 498761002347 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 498761002348 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 498761002349 4Fe-4S binding domain; Region: Fer4; pfam00037 498761002350 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498761002351 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 498761002352 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 498761002353 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 498761002354 putative dimer interface [polypeptide binding]; other site 498761002355 [2Fe-2S] cluster binding site [ion binding]; other site 498761002356 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 498761002357 dimer interface [polypeptide binding]; other site 498761002358 [2Fe-2S] cluster binding site [ion binding]; other site 498761002359 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 498761002360 SLBB domain; Region: SLBB; pfam10531 498761002361 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 498761002362 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 498761002363 4Fe-4S binding domain; Region: Fer4; pfam00037 498761002364 4Fe-4S binding domain; Region: Fer4; pfam00037 498761002365 Ion transport protein; Region: Ion_trans; pfam00520 498761002366 Ion channel; Region: Ion_trans_2; pfam07885 498761002367 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 498761002368 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 498761002369 putative active site [active] 498761002370 metal binding site [ion binding]; metal-binding site 498761002371 Thymidylate synthase complementing protein; Region: Thy1; cl03630 498761002372 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 498761002373 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 498761002374 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 498761002375 active site 498761002376 HIGH motif; other site 498761002377 nucleotide binding site [chemical binding]; other site 498761002378 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 498761002379 KMSKS motif; other site 498761002380 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 498761002381 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 498761002382 dimer interface [polypeptide binding]; other site 498761002383 substrate binding site [chemical binding]; other site 498761002384 ATP binding site [chemical binding]; other site 498761002385 Small acid-soluble spore protein H family; Region: SspH; pfam08141 498761002386 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 498761002387 EamA-like transporter family; Region: EamA; pfam00892 498761002388 EamA-like transporter family; Region: EamA; pfam00892 498761002389 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 498761002390 active site 498761002391 catalytic triad [active] 498761002392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002393 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761002394 Walker A motif; other site 498761002395 ATP binding site [chemical binding]; other site 498761002396 Walker B motif; other site 498761002397 arginine finger; other site 498761002398 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 498761002399 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 498761002400 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 498761002401 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 498761002402 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 498761002403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002404 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 498761002405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761002406 ATP binding site [chemical binding]; other site 498761002407 putative Mg++ binding site [ion binding]; other site 498761002408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761002409 nucleotide binding region [chemical binding]; other site 498761002410 ATP-binding site [chemical binding]; other site 498761002411 Helicase associated domain (HA2); Region: HA2; pfam04408 498761002412 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 498761002413 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 498761002414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761002415 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 498761002416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498761002417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002418 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 498761002419 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 498761002420 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 498761002421 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 498761002422 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 498761002423 putative ligand binding site [chemical binding]; other site 498761002424 putative NAD binding site [chemical binding]; other site 498761002425 catalytic site [active] 498761002426 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 498761002427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498761002428 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 498761002429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761002430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761002431 homodimer interface [polypeptide binding]; other site 498761002432 catalytic residue [active] 498761002433 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 498761002434 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 498761002435 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 498761002436 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498761002437 protein binding site [polypeptide binding]; other site 498761002438 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 498761002439 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 498761002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761002441 S-adenosylmethionine binding site [chemical binding]; other site 498761002442 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 498761002443 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 498761002444 hinge; other site 498761002445 active site 498761002446 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 498761002447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498761002448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761002449 binding surface 498761002450 TPR motif; other site 498761002451 TPR repeat; Region: TPR_11; pfam13414 498761002452 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 498761002453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498761002454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002455 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761002456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761002457 G5 domain; Region: G5; pfam07501 498761002458 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761002459 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 498761002460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761002461 FeS/SAM binding site; other site 498761002462 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 498761002463 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 498761002464 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 498761002465 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 498761002466 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 498761002467 GDP-binding site [chemical binding]; other site 498761002468 ACT binding site; other site 498761002469 IMP binding site; other site 498761002470 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 498761002471 active site clefts [active] 498761002472 zinc binding site [ion binding]; other site 498761002473 dimer interface [polypeptide binding]; other site 498761002474 replicative DNA helicase; Region: DnaB; TIGR00665 498761002475 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 498761002476 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 498761002477 Walker A motif; other site 498761002478 ATP binding site [chemical binding]; other site 498761002479 Walker B motif; other site 498761002480 DNA binding loops [nucleotide binding] 498761002481 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 498761002482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002483 Walker A motif; other site 498761002484 ATP binding site [chemical binding]; other site 498761002485 Walker B motif; other site 498761002486 arginine finger; other site 498761002487 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498761002488 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 498761002489 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 498761002490 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 498761002491 Bacitracin resistance protein BacA; Region: BacA; cl00858 498761002492 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 498761002493 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 498761002494 DHH family; Region: DHH; pfam01368 498761002495 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 498761002496 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498761002497 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498761002498 dimer interface [polypeptide binding]; other site 498761002499 ssDNA binding site [nucleotide binding]; other site 498761002500 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498761002501 GTP-binding protein YchF; Reviewed; Region: PRK09601 498761002502 YchF GTPase; Region: YchF; cd01900 498761002503 G1 box; other site 498761002504 GTP/Mg2+ binding site [chemical binding]; other site 498761002505 Switch I region; other site 498761002506 G2 box; other site 498761002507 Switch II region; other site 498761002508 G3 box; other site 498761002509 G4 box; other site 498761002510 G5 box; other site 498761002511 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 498761002512 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 498761002513 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 498761002514 Mechanosensitive ion channel; Region: MS_channel; pfam00924 498761002515 DsrE/DsrF-like family; Region: DrsE; cl00672 498761002516 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 498761002517 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 498761002518 oligomer interface [polypeptide binding]; other site 498761002519 putative active site [active] 498761002520 metal binding site [ion binding]; metal-binding site 498761002521 DNA replication protein DnaC; Validated; Region: PRK06835 498761002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002523 Walker A motif; other site 498761002524 ATP binding site [chemical binding]; other site 498761002525 Walker B motif; other site 498761002526 arginine finger; other site 498761002527 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 498761002528 Predicted transcriptional regulator [Transcription]; Region: COG1959 498761002529 Transcriptional regulator; Region: Rrf2; cl17282 498761002530 DEAD-like helicases superfamily; Region: DEXDc; smart00487 498761002531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761002532 ATP binding site [chemical binding]; other site 498761002533 putative Mg++ binding site [ion binding]; other site 498761002534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761002535 nucleotide binding region [chemical binding]; other site 498761002536 ATP-binding site [chemical binding]; other site 498761002537 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 498761002538 TIGR03943 family protein; Region: TIGR03943 498761002539 Predicted permeases [General function prediction only]; Region: COG0701 498761002540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761002541 dimerization interface [polypeptide binding]; other site 498761002542 putative DNA binding site [nucleotide binding]; other site 498761002543 putative Zn2+ binding site [ion binding]; other site 498761002544 acetyl-CoA synthetase; Provisional; Region: PRK04319 498761002545 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 498761002546 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 498761002547 active site 498761002548 acyl-activating enzyme (AAE) consensus motif; other site 498761002549 putative CoA binding site [chemical binding]; other site 498761002550 AMP binding site [chemical binding]; other site 498761002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498761002552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498761002553 putative substrate translocation pore; other site 498761002554 Protein of unknown function (DUF441); Region: DUF441; pfam04284 498761002555 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 498761002556 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 498761002557 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498761002558 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498761002559 NodB motif; other site 498761002560 active site 498761002561 catalytic site [active] 498761002562 Zn binding site [ion binding]; other site 498761002563 ThiS family; Region: ThiS; pfam02597 498761002564 charged pocket; other site 498761002565 hydrophobic patch; other site 498761002566 Spore germination protein; Region: Spore_permease; cl17796 498761002567 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498761002568 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498761002569 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498761002570 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761002571 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761002572 putative active site [active] 498761002573 putative NTP binding site [chemical binding]; other site 498761002574 putative nucleic acid binding site [nucleotide binding]; other site 498761002575 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761002576 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761002577 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761002578 putative active site [active] 498761002579 putative NTP binding site [chemical binding]; other site 498761002580 putative nucleic acid binding site [nucleotide binding]; other site 498761002581 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761002582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761002583 Transposase; Region: HTH_Tnp_1; pfam01527 498761002584 putative transposase OrfB; Reviewed; Region: PHA02517 498761002585 HTH-like domain; Region: HTH_21; pfam13276 498761002586 Integrase core domain; Region: rve; pfam00665 498761002587 Integrase core domain; Region: rve_3; pfam13683 498761002588 DDE superfamily endonuclease; Region: DDE_5; cl17874 498761002589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761002590 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 498761002591 Transposase domain (DUF772); Region: DUF772; pfam05598 498761002592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761002593 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761002594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 498761002595 Transposase; Region: DDE_Tnp_ISL3; pfam01610 498761002596 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 498761002597 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761002598 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 498761002599 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 498761002600 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 498761002601 G1 box; other site 498761002602 putative GEF interaction site [polypeptide binding]; other site 498761002603 GTP/Mg2+ binding site [chemical binding]; other site 498761002604 Switch I region; other site 498761002605 G2 box; other site 498761002606 G3 box; other site 498761002607 Switch II region; other site 498761002608 G4 box; other site 498761002609 G5 box; other site 498761002610 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 498761002611 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 498761002612 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 498761002613 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 498761002614 Uncharacterized membrane protein [Function unknown]; Region: COG3949 498761002615 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 498761002616 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 498761002617 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 498761002618 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761002619 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761002620 Protein of unknown function (DUF554); Region: DUF554; pfam04474 498761002621 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 498761002622 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 498761002623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761002624 catalytic residue [active] 498761002625 ParB-like nuclease domain; Region: ParBc; pfam02195 498761002626 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 498761002627 KorB domain; Region: KorB; pfam08535 498761002628 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 498761002629 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 498761002630 P-loop; other site 498761002631 Magnesium ion binding site [ion binding]; other site 498761002632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761002633 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 498761002634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761002635 S-adenosylmethionine binding site [chemical binding]; other site 498761002636 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 498761002637 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 498761002638 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 498761002639 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 498761002640 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 498761002641 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 498761002642 trmE is a tRNA modification GTPase; Region: trmE; cd04164 498761002643 G1 box; other site 498761002644 GTP/Mg2+ binding site [chemical binding]; other site 498761002645 Switch I region; other site 498761002646 G2 box; other site 498761002647 Switch II region; other site 498761002648 G3 box; other site 498761002649 G4 box; other site 498761002650 G5 box; other site 498761002651 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 498761002652 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 498761002653 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 498761002654 G-X-X-G motif; other site 498761002655 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 498761002656 RxxxH motif; other site 498761002657 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 498761002658 Haemolytic domain; Region: Haemolytic; pfam01809 498761002659 ribonuclease P; Reviewed; Region: rnpA; PRK00499 498761002660 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 498761002661 DnaA N-terminal domain; Region: DnaA_N; pfam11638 498761002662 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 498761002663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002664 Walker A motif; other site 498761002665 ATP binding site [chemical binding]; other site 498761002666 Walker B motif; other site 498761002667 arginine finger; other site 498761002668 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 498761002669 DnaA box-binding interface [nucleotide binding]; other site 498761002670 DNA polymerase III subunit beta; Validated; Region: PRK05643 498761002671 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 498761002672 putative DNA binding surface [nucleotide binding]; other site 498761002673 dimer interface [polypeptide binding]; other site 498761002674 beta-clamp/clamp loader binding surface; other site 498761002675 beta-clamp/translesion DNA polymerase binding surface; other site 498761002676 recombination protein F; Reviewed; Region: recF; PRK00064 498761002677 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 498761002678 Walker A/P-loop; other site 498761002679 ATP binding site [chemical binding]; other site 498761002680 Q-loop/lid; other site 498761002681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761002682 ABC transporter signature motif; other site 498761002683 Walker B; other site 498761002684 D-loop; other site 498761002685 H-loop/switch region; other site 498761002686 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 498761002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761002688 ATP binding site [chemical binding]; other site 498761002689 Mg2+ binding site [ion binding]; other site 498761002690 G-X-G motif; other site 498761002691 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 498761002692 anchoring element; other site 498761002693 dimer interface [polypeptide binding]; other site 498761002694 ATP binding site [chemical binding]; other site 498761002695 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 498761002696 active site 498761002697 putative metal-binding site [ion binding]; other site 498761002698 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 498761002699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498761002700 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 498761002701 FAD binding site [chemical binding]; other site 498761002702 homotetramer interface [polypeptide binding]; other site 498761002703 substrate binding pocket [chemical binding]; other site 498761002704 catalytic base [active] 498761002705 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 498761002706 B12 binding site [chemical binding]; other site 498761002707 cobalt ligand [ion binding]; other site 498761002708 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761002709 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 498761002710 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 498761002711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761002712 acyl-activating enzyme (AAE) consensus motif; other site 498761002713 AMP binding site [chemical binding]; other site 498761002714 active site 498761002715 CoA binding site [chemical binding]; other site 498761002716 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 498761002717 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 498761002718 dimer interface [polypeptide binding]; other site 498761002719 active site 498761002720 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 498761002721 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 498761002722 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 498761002723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498761002724 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 498761002725 FAD binding site [chemical binding]; other site 498761002726 homotetramer interface [polypeptide binding]; other site 498761002727 substrate binding pocket [chemical binding]; other site 498761002728 catalytic base [active] 498761002729 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 498761002730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 498761002731 substrate binding site [chemical binding]; other site 498761002732 oxyanion hole (OAH) forming residues; other site 498761002733 trimer interface [polypeptide binding]; other site 498761002734 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498761002735 Ligand binding site [chemical binding]; other site 498761002736 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498761002737 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498761002738 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498761002739 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498761002740 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 498761002741 Cysteine-rich domain; Region: CCG; pfam02754 498761002742 Cysteine-rich domain; Region: CCG; pfam02754 498761002743 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 498761002744 FMN binding site [chemical binding]; other site 498761002745 dimer interface [polypeptide binding]; other site 498761002746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 498761002747 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 498761002748 Walker A/P-loop; other site 498761002749 ATP binding site [chemical binding]; other site 498761002750 Q-loop/lid; other site 498761002751 ABC transporter signature motif; other site 498761002752 Walker B; other site 498761002753 D-loop; other site 498761002754 H-loop/switch region; other site 498761002755 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 498761002756 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 498761002757 Walker A/P-loop; other site 498761002758 ATP binding site [chemical binding]; other site 498761002759 Q-loop/lid; other site 498761002760 ABC transporter signature motif; other site 498761002761 Walker B; other site 498761002762 D-loop; other site 498761002763 H-loop/switch region; other site 498761002764 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 498761002765 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 498761002766 TM-ABC transporter signature motif; other site 498761002767 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761002768 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 498761002769 TM-ABC transporter signature motif; other site 498761002770 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761002771 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 498761002772 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498761002773 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 498761002774 DNA gyrase subunit A; Validated; Region: PRK05560 498761002775 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 498761002776 CAP-like domain; other site 498761002777 active site 498761002778 primary dimer interface [polypeptide binding]; other site 498761002779 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498761002785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498761002786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498761002787 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 498761002788 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 498761002789 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498761002790 carboxyltransferase (CT) interaction site; other site 498761002791 biotinylation site [posttranslational modification]; other site 498761002792 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761002793 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 498761002794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761002795 Walker A/P-loop; other site 498761002796 ATP binding site [chemical binding]; other site 498761002797 Q-loop/lid; other site 498761002798 ABC transporter signature motif; other site 498761002799 Walker B; other site 498761002800 D-loop; other site 498761002801 H-loop/switch region; other site 498761002802 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 498761002803 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498761002804 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 498761002805 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 498761002806 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 498761002807 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 498761002808 putative active site [active] 498761002809 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 498761002810 hexamer interface [polypeptide binding]; other site 498761002811 RNA binding site [nucleotide binding]; other site 498761002812 Histidine-zinc binding site [chemical binding]; other site 498761002813 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 498761002814 Nitrogen regulatory protein P-II; Region: P-II; smart00938 498761002815 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 498761002816 Nitrogen regulatory protein P-II; Region: P-II; smart00938 498761002817 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 498761002818 nitrogenase iron protein; Region: nifH; TIGR01287 498761002819 Nucleotide-binding sites [chemical binding]; other site 498761002820 Walker A motif; other site 498761002821 Switch I region of nucleotide binding site; other site 498761002822 Fe4S4 binding sites [ion binding]; other site 498761002823 Switch II region of nucleotide binding site; other site 498761002824 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 498761002825 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 498761002826 MoFe protein alpha/beta subunit interactions; other site 498761002827 Alpha subunit P cluster binding residues; other site 498761002828 FeMoco binding residues [chemical binding]; other site 498761002829 MoFe protein alpha subunit/Fe protein contacts; other site 498761002830 MoFe protein dimer/ dimer interactions; other site 498761002831 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 498761002832 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 498761002833 MoFe protein beta/alpha subunit interactions; other site 498761002834 Beta subunit P cluster binding residues; other site 498761002835 MoFe protein beta subunit/Fe protein contacts; other site 498761002836 MoFe protein dimer/ dimer interactions; other site 498761002837 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 498761002838 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 498761002839 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 498761002840 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 498761002841 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 498761002842 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 498761002843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761002844 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498761002845 FeS/SAM binding site; other site 498761002846 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 498761002847 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 498761002848 active site 498761002849 catalytic residues [active] 498761002850 metal binding site [ion binding]; metal-binding site 498761002851 Sm and related proteins; Region: Sm_like; cl00259 498761002852 Sm1 motif; other site 498761002853 RNA binding site [nucleotide binding]; other site 498761002854 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 498761002855 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 498761002856 active site 498761002857 multimer interface [polypeptide binding]; other site 498761002858 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 498761002859 predicted active site [active] 498761002860 catalytic triad [active] 498761002861 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 498761002862 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 498761002863 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 498761002864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761002865 catalytic residue [active] 498761002866 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 498761002867 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 498761002868 ligand binding site [chemical binding]; other site 498761002869 NAD binding site [chemical binding]; other site 498761002870 dimerization interface [polypeptide binding]; other site 498761002871 catalytic site [active] 498761002872 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 498761002873 putative L-serine binding site [chemical binding]; other site 498761002874 seryl-tRNA synthetase; Provisional; Region: PRK05431 498761002875 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 498761002876 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 498761002877 dimer interface [polypeptide binding]; other site 498761002878 active site 498761002879 motif 1; other site 498761002880 motif 2; other site 498761002881 motif 3; other site 498761002882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 498761002883 FOG: CBS domain [General function prediction only]; Region: COG0517 498761002884 FOG: CBS domain [General function prediction only]; Region: COG0517 498761002885 FOG: CBS domain [General function prediction only]; Region: COG0517 498761002886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 498761002887 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498761002888 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 498761002889 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 498761002890 PAS domain; Region: PAS; smart00091 498761002891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761002892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761002893 metal binding site [ion binding]; metal-binding site 498761002894 active site 498761002895 I-site; other site 498761002896 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 498761002897 homotrimer interaction site [polypeptide binding]; other site 498761002898 putative active site [active] 498761002899 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 498761002900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002901 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 498761002902 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498761002903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761002904 dimerization interface [polypeptide binding]; other site 498761002905 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761002906 dimer interface [polypeptide binding]; other site 498761002907 putative CheW interface [polypeptide binding]; other site 498761002908 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 498761002909 dimerization domain swap beta strand [polypeptide binding]; other site 498761002910 regulatory protein interface [polypeptide binding]; other site 498761002911 active site 498761002912 regulatory phosphorylation site [posttranslational modification]; other site 498761002913 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498761002914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761002915 putative active site [active] 498761002916 heme pocket [chemical binding]; other site 498761002917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761002918 putative active site [active] 498761002919 heme pocket [chemical binding]; other site 498761002920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002921 Walker A motif; other site 498761002922 ATP binding site [chemical binding]; other site 498761002923 Walker B motif; other site 498761002924 arginine finger; other site 498761002925 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 498761002926 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 498761002927 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 498761002928 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 498761002929 active pocket/dimerization site; other site 498761002930 active site 498761002931 phosphorylation site [posttranslational modification] 498761002932 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 498761002933 dimerization domain swap beta strand [polypeptide binding]; other site 498761002934 regulatory protein interface [polypeptide binding]; other site 498761002935 active site 498761002936 regulatory phosphorylation site [posttranslational modification]; other site 498761002937 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 498761002938 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 498761002939 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 498761002940 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 498761002941 Transcriptional regulator PadR-like family; Region: PadR; cl17335 498761002942 Predicted transcriptional regulators [Transcription]; Region: COG1695 498761002943 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 498761002944 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 498761002945 P loop nucleotide binding; other site 498761002946 switch II; other site 498761002947 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 498761002948 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 498761002949 P loop nucleotide binding; other site 498761002950 switch II; other site 498761002951 Uncharacterized conserved protein [Function unknown]; Region: COG1433 498761002952 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 498761002953 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 498761002954 nucleoside/Zn binding site; other site 498761002955 dimer interface [polypeptide binding]; other site 498761002956 catalytic motif [active] 498761002957 Fic family protein [Function unknown]; Region: COG3177 498761002958 Fic/DOC family; Region: Fic; pfam02661 498761002959 CoA binding domain; Region: CoA_binding_2; pfam13380 498761002960 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 498761002961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761002962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 498761002963 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 498761002964 active site residue [active] 498761002965 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 498761002966 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761002967 putative homodimer interface [polypeptide binding]; other site 498761002968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761002969 dimerization interface [polypeptide binding]; other site 498761002970 GAF domain; Region: GAF_3; pfam13492 498761002971 GAF domain; Region: GAF_2; pfam13185 498761002972 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761002973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761002974 Zn2+ binding site [ion binding]; other site 498761002975 Mg2+ binding site [ion binding]; other site 498761002976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761002977 dimer interface [polypeptide binding]; other site 498761002978 phosphorylation site [posttranslational modification] 498761002979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761002980 ATP binding site [chemical binding]; other site 498761002981 Mg2+ binding site [ion binding]; other site 498761002982 G-X-G motif; other site 498761002983 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 498761002984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761002985 Walker A motif; other site 498761002986 ATP binding site [chemical binding]; other site 498761002987 Walker B motif; other site 498761002988 arginine finger; other site 498761002989 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 498761002990 hypothetical protein; Validated; Region: PRK00153 498761002991 recombination protein RecR; Reviewed; Region: recR; PRK00076 498761002992 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 498761002993 RecR protein; Region: RecR; pfam02132 498761002994 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 498761002995 putative active site [active] 498761002996 putative metal-binding site [ion binding]; other site 498761002997 tetramer interface [polypeptide binding]; other site 498761002998 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 498761002999 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 498761003000 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761003001 dimer interface [polypeptide binding]; other site 498761003002 PYR/PP interface [polypeptide binding]; other site 498761003003 TPP binding site [chemical binding]; other site 498761003004 substrate binding site [chemical binding]; other site 498761003005 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 498761003006 Domain of unknown function; Region: EKR; smart00890 498761003007 4Fe-4S binding domain; Region: Fer4_6; pfam12837 498761003008 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 498761003009 TPP-binding site [chemical binding]; other site 498761003010 dimer interface [polypeptide binding]; other site 498761003011 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 498761003012 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761003013 dimer interface [polypeptide binding]; other site 498761003014 PYR/PP interface [polypeptide binding]; other site 498761003015 TPP binding site [chemical binding]; other site 498761003016 substrate binding site [chemical binding]; other site 498761003017 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498761003018 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 498761003019 TPP-binding site [chemical binding]; other site 498761003020 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 498761003021 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 498761003022 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761003023 Uncharacterized conserved protein [Function unknown]; Region: COG1432 498761003024 LabA_like proteins; Region: LabA_like; cd06167 498761003025 putative metal binding site [ion binding]; other site 498761003026 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 498761003027 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 498761003028 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 498761003029 GGGtGRT protein; Region: GGGtGRT; pfam14057 498761003030 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 498761003031 SEC-C motif; Region: SEC-C; pfam02810 498761003032 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 498761003033 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498761003034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761003035 ATP binding site [chemical binding]; other site 498761003036 putative Mg++ binding site [ion binding]; other site 498761003037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761003038 nucleotide binding region [chemical binding]; other site 498761003039 ATP-binding site [chemical binding]; other site 498761003040 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 498761003041 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 498761003042 active site 498761003043 catalytic residues [active] 498761003044 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 498761003045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 498761003046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 498761003047 DNA binding residues [nucleotide binding] 498761003048 dimerization interface [polypeptide binding]; other site 498761003049 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 498761003050 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498761003051 catalytic residues [active] 498761003052 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 498761003053 Predicted permeases [General function prediction only]; Region: COG0701 498761003054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761003055 dimerization interface [polypeptide binding]; other site 498761003056 putative DNA binding site [nucleotide binding]; other site 498761003057 putative Zn2+ binding site [ion binding]; other site 498761003058 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 498761003059 arsenical-resistance protein; Region: acr3; TIGR00832 498761003060 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498761003061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761003062 Walker A/P-loop; other site 498761003063 ATP binding site [chemical binding]; other site 498761003064 Q-loop/lid; other site 498761003065 ABC transporter signature motif; other site 498761003066 Walker B; other site 498761003067 D-loop; other site 498761003068 H-loop/switch region; other site 498761003069 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498761003070 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761003071 Walker A/P-loop; other site 498761003072 ATP binding site [chemical binding]; other site 498761003073 Q-loop/lid; other site 498761003074 ABC transporter signature motif; other site 498761003075 Walker B; other site 498761003076 D-loop; other site 498761003077 H-loop/switch region; other site 498761003078 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 498761003079 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 498761003080 Sel1-like repeats; Region: SEL1; smart00671 498761003081 Sel1-like repeats; Region: SEL1; smart00671 498761003082 Sel1-like repeats; Region: SEL1; smart00671 498761003083 Sel1-like repeats; Region: SEL1; smart00671 498761003084 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498761003085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498761003086 glyoxylate reductase; Reviewed; Region: PRK13243 498761003087 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 498761003088 dimerization interface [polypeptide binding]; other site 498761003089 ligand binding site [chemical binding]; other site 498761003090 NADP binding site [chemical binding]; other site 498761003091 catalytic site [active] 498761003092 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 498761003093 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 498761003094 metal binding site [ion binding]; metal-binding site 498761003095 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 498761003096 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 498761003097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498761003098 nucleotide binding site [chemical binding]; other site 498761003099 Hexokinase; Region: Hexokinase_2; pfam03727 498761003100 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 498761003101 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 498761003102 N-acetyl-D-glucosamine binding site [chemical binding]; other site 498761003103 catalytic residue [active] 498761003104 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498761003105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761003106 catalytic residue [active] 498761003107 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 498761003108 thymidylate kinase; Validated; Region: tmk; PRK00698 498761003109 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 498761003110 TMP-binding site; other site 498761003111 ATP-binding site [chemical binding]; other site 498761003112 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 498761003113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003114 Walker A motif; other site 498761003115 ATP binding site [chemical binding]; other site 498761003116 Walker B motif; other site 498761003117 arginine finger; other site 498761003118 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 498761003119 Protein of unknown function (DUF972); Region: DUF972; pfam06156 498761003120 Predicted methyltransferases [General function prediction only]; Region: COG0313 498761003121 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 498761003122 putative SAM binding site [chemical binding]; other site 498761003123 putative homodimer interface [polypeptide binding]; other site 498761003124 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 498761003125 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 498761003126 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 498761003127 active site 498761003128 HIGH motif; other site 498761003129 KMSKS motif; other site 498761003130 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 498761003131 tRNA binding surface [nucleotide binding]; other site 498761003132 anticodon binding site; other site 498761003133 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 498761003134 dimer interface [polypeptide binding]; other site 498761003135 putative tRNA-binding site [nucleotide binding]; other site 498761003136 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 498761003137 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 498761003138 active site 498761003139 Domain of unknown function (DUF348); Region: DUF348; pfam03990 498761003140 G5 domain; Region: G5; pfam07501 498761003141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 498761003142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 498761003143 G5 domain; Region: G5; pfam07501 498761003144 3D domain; Region: 3D; cl01439 498761003145 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761003146 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761003147 putative active site [active] 498761003148 putative NTP binding site [chemical binding]; other site 498761003149 putative nucleic acid binding site [nucleotide binding]; other site 498761003150 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761003151 Transposase domain (DUF772); Region: DUF772; pfam05598 498761003152 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761003153 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761003154 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 498761003155 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 498761003156 putative active site [active] 498761003157 putative metal binding site [ion binding]; other site 498761003158 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 498761003159 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 498761003160 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 498761003161 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 498761003162 Nitrogen regulatory protein P-II; Region: P-II; smart00938 498761003163 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 498761003164 YabG peptidase U57; Region: Peptidase_U57; cl05250 498761003165 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 498761003166 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 498761003167 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 498761003168 Transcriptional regulators [Transcription]; Region: FadR; COG2186 498761003169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498761003170 DNA-binding site [nucleotide binding]; DNA binding site 498761003171 FCD domain; Region: FCD; pfam07729 498761003172 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 498761003173 active site 498761003174 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 498761003175 dinuclear metal binding motif [ion binding]; other site 498761003176 threonine dehydratase; Provisional; Region: PRK08198 498761003177 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 498761003178 tetramer interface [polypeptide binding]; other site 498761003179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761003180 catalytic residue [active] 498761003181 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 498761003182 regulatory protein SpoVG; Reviewed; Region: PRK13259 498761003183 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 498761003184 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 498761003185 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 498761003186 Substrate binding site; other site 498761003187 Mg++ binding site; other site 498761003188 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 498761003189 active site 498761003190 substrate binding site [chemical binding]; other site 498761003191 CoA binding site [chemical binding]; other site 498761003192 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 498761003193 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 498761003194 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761003195 active site 498761003196 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 498761003197 PRC-barrel domain; Region: PRC; pfam05239 498761003198 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 498761003199 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 498761003200 5S rRNA interface [nucleotide binding]; other site 498761003201 CTC domain interface [polypeptide binding]; other site 498761003202 L16 interface [polypeptide binding]; other site 498761003203 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 498761003204 putative active site [active] 498761003205 catalytic residue [active] 498761003206 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 498761003207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761003208 Zn2+ binding site [ion binding]; other site 498761003209 Mg2+ binding site [ion binding]; other site 498761003210 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 498761003211 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 498761003212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761003213 ATP binding site [chemical binding]; other site 498761003214 putative Mg++ binding site [ion binding]; other site 498761003215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761003216 nucleotide binding region [chemical binding]; other site 498761003217 ATP-binding site [chemical binding]; other site 498761003218 TRCF domain; Region: TRCF; pfam03461 498761003219 SurA N-terminal domain; Region: SurA_N_3; cl07813 498761003220 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 498761003221 stage V sporulation protein T; Region: spore_V_T; TIGR02851 498761003222 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 498761003223 GAF domain; Region: GAF; cl17456 498761003224 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 498761003225 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 498761003226 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 498761003227 putative SAM binding site [chemical binding]; other site 498761003228 putative homodimer interface [polypeptide binding]; other site 498761003229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 498761003230 homodimer interface [polypeptide binding]; other site 498761003231 metal binding site [ion binding]; metal-binding site 498761003232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 498761003233 homodimer interface [polypeptide binding]; other site 498761003234 active site 498761003235 putative chemical substrate binding site [chemical binding]; other site 498761003236 metal binding site [ion binding]; metal-binding site 498761003237 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 498761003238 IHF dimer interface [polypeptide binding]; other site 498761003239 IHF - DNA interface [nucleotide binding]; other site 498761003240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761003241 RNA binding surface [nucleotide binding]; other site 498761003242 YabP family; Region: YabP; cl06766 498761003243 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 498761003244 Septum formation initiator; Region: DivIC; pfam04977 498761003245 exopolyphosphatase; Region: exo_poly_only; TIGR03706 498761003246 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 498761003247 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 498761003248 catalytic triad [active] 498761003249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761003250 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 498761003251 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 498761003252 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 498761003253 tRNA; other site 498761003254 putative tRNA binding site [nucleotide binding]; other site 498761003255 putative NADP binding site [chemical binding]; other site 498761003256 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 498761003257 Cytochrome c; Region: Cytochrom_C; pfam00034 498761003258 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 498761003259 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 498761003260 iron-sulfur cluster [ion binding]; other site 498761003261 [2Fe-2S] cluster binding site [ion binding]; other site 498761003262 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 498761003263 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 498761003264 Qi binding site; other site 498761003265 intrachain domain interface; other site 498761003266 interchain domain interface [polypeptide binding]; other site 498761003267 heme bH binding site [chemical binding]; other site 498761003268 heme bL binding site [chemical binding]; other site 498761003269 Qo binding site; other site 498761003270 intrachain domain interface; other site 498761003271 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 498761003272 Qo binding site; other site 498761003273 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 498761003274 Cytochrome c; Region: Cytochrom_C; pfam00034 498761003275 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 498761003276 TspO/MBR family; Region: TspO_MBR; pfam03073 498761003277 V4R domain; Region: V4R; cl15268 498761003278 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 498761003279 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 498761003280 UbiA prenyltransferase family; Region: UbiA; pfam01040 498761003281 Photosystem II protein; Region: PSII; cl08223 498761003282 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 498761003283 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 498761003284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761003285 S-adenosylmethionine binding site [chemical binding]; other site 498761003286 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 498761003287 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 498761003288 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 498761003289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761003290 FeS/SAM binding site; other site 498761003291 light-independent protochlorophyllide reductase, iron-sulfur ATP-binding protein; Region: DPOR_bchL; TIGR01281 498761003292 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 498761003293 P-loop; other site 498761003294 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 498761003295 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 498761003296 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 498761003297 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 498761003298 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 498761003299 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 498761003300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003301 Walker A motif; other site 498761003302 ATP binding site [chemical binding]; other site 498761003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003304 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 498761003305 Walker A motif; other site 498761003306 ATP binding site [chemical binding]; other site 498761003307 Walker B motif; other site 498761003308 arginine finger; other site 498761003309 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 498761003310 metal ion-dependent adhesion site (MIDAS); other site 498761003311 magnesium chelatase subunit H; Provisional; Region: PRK12493 498761003312 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 498761003313 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 498761003314 carotene isomerase; Region: carot_isom; TIGR02730 498761003315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498761003316 hydroxyglutarate oxidase; Provisional; Region: PRK11728 498761003317 stage II sporulation protein E; Region: spore_II_E; TIGR02865 498761003318 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 498761003319 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 498761003320 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 498761003321 Ligand Binding Site [chemical binding]; other site 498761003322 TilS substrate C-terminal domain; Region: TilS_C; smart00977 498761003323 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 498761003324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003325 Walker A motif; other site 498761003326 ATP binding site [chemical binding]; other site 498761003327 Walker B motif; other site 498761003328 arginine finger; other site 498761003329 Peptidase family M41; Region: Peptidase_M41; pfam01434 498761003330 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 498761003331 active site 498761003332 multimer interface [polypeptide binding]; other site 498761003333 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 498761003334 ABC1 family; Region: ABC1; cl17513 498761003335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498761003336 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 498761003337 NAD(P) binding site [chemical binding]; other site 498761003338 active site 498761003339 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 498761003340 active site 1 [active] 498761003341 active site 2 [active] 498761003342 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 498761003343 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 498761003344 Potassium binding sites [ion binding]; other site 498761003345 Cesium cation binding sites [ion binding]; other site 498761003346 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761003347 Zn2+ binding site [ion binding]; other site 498761003348 Mg2+ binding site [ion binding]; other site 498761003349 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 498761003350 dihydropteroate synthase; Region: DHPS; TIGR01496 498761003351 substrate binding pocket [chemical binding]; other site 498761003352 dimer interface [polypeptide binding]; other site 498761003353 inhibitor binding site; inhibition site 498761003354 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 498761003355 homooctamer interface [polypeptide binding]; other site 498761003356 active site 498761003357 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 498761003358 catalytic center binding site [active] 498761003359 ATP binding site [chemical binding]; other site 498761003360 pantoate--beta-alanine ligase; Region: panC; TIGR00018 498761003361 Pantoate-beta-alanine ligase; Region: PanC; cd00560 498761003362 active site 498761003363 ATP-binding site [chemical binding]; other site 498761003364 pantoate-binding site; other site 498761003365 HXXH motif; other site 498761003366 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 498761003367 tetramerization interface [polypeptide binding]; other site 498761003368 active site 498761003369 Quinolinate synthetase A protein; Region: NadA; pfam02445 498761003370 L-aspartate oxidase; Provisional; Region: PRK06175 498761003371 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 498761003372 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 498761003373 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 498761003374 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 498761003375 dimerization interface [polypeptide binding]; other site 498761003376 active site 498761003377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761003378 putative DNA binding site [nucleotide binding]; other site 498761003379 dimerization interface [polypeptide binding]; other site 498761003380 putative Zn2+ binding site [ion binding]; other site 498761003381 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 498761003382 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 498761003383 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 498761003384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498761003385 nucleotide binding site [chemical binding]; other site 498761003386 Type III pantothenate kinase; Region: Pan_kinase; cl17198 498761003387 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 498761003388 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 498761003389 FMN binding site [chemical binding]; other site 498761003390 active site 498761003391 catalytic residues [active] 498761003392 substrate binding site [chemical binding]; other site 498761003393 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 498761003394 Isochorismatase family; Region: Isochorismatase; pfam00857 498761003395 catalytic triad [active] 498761003396 dimer interface [polypeptide binding]; other site 498761003397 conserved cis-peptide bond; other site 498761003398 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761003399 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 498761003400 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 498761003401 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 498761003402 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 498761003403 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 498761003404 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 498761003405 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 498761003406 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 498761003407 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 498761003408 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 498761003409 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 498761003410 NAD(P) binding pocket [chemical binding]; other site 498761003411 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 498761003412 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 498761003413 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 498761003414 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 498761003415 dimer interface [polypeptide binding]; other site 498761003416 putative anticodon binding site; other site 498761003417 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498761003418 motif 1; other site 498761003419 dimer interface [polypeptide binding]; other site 498761003420 motif 2; other site 498761003421 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498761003422 active site 498761003423 motif 3; other site 498761003424 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761003425 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761003426 putative active site [active] 498761003427 putative NTP binding site [chemical binding]; other site 498761003428 putative nucleic acid binding site [nucleotide binding]; other site 498761003429 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761003430 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 498761003431 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 498761003432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761003433 non-specific DNA binding site [nucleotide binding]; other site 498761003434 salt bridge; other site 498761003435 sequence-specific DNA binding site [nucleotide binding]; other site 498761003436 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 498761003437 Clp amino terminal domain; Region: Clp_N; pfam02861 498761003438 Clp amino terminal domain; Region: Clp_N; pfam02861 498761003439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003440 Walker A motif; other site 498761003441 ATP binding site [chemical binding]; other site 498761003442 Walker B motif; other site 498761003443 arginine finger; other site 498761003444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003445 Walker A motif; other site 498761003446 ATP binding site [chemical binding]; other site 498761003447 Walker B motif; other site 498761003448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 498761003449 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 498761003450 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 498761003451 UvrB/uvrC motif; Region: UVR; pfam02151 498761003452 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 498761003453 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 498761003454 ADP binding site [chemical binding]; other site 498761003455 phosphagen binding site; other site 498761003456 substrate specificity loop; other site 498761003457 Clp protease ATP binding subunit; Region: clpC; CHL00095 498761003458 Clp amino terminal domain; Region: Clp_N; pfam02861 498761003459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003460 Walker A motif; other site 498761003461 ATP binding site [chemical binding]; other site 498761003462 Walker B motif; other site 498761003463 arginine finger; other site 498761003464 UvrB/uvrC motif; Region: UVR; pfam02151 498761003465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761003466 Walker A motif; other site 498761003467 ATP binding site [chemical binding]; other site 498761003468 Walker B motif; other site 498761003469 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 498761003470 DNA repair protein RadA; Provisional; Region: PRK11823 498761003471 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 498761003472 Walker A motif/ATP binding site; other site 498761003473 ATP binding site [chemical binding]; other site 498761003474 Walker B motif; other site 498761003475 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 498761003476 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 498761003477 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 498761003478 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 498761003479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 498761003480 Coat F domain; Region: Coat_F; pfam07875 498761003481 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 498761003482 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 498761003483 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 498761003484 putative active site [active] 498761003485 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 498761003486 substrate binding site; other site 498761003487 dimer interface; other site 498761003488 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 498761003489 homotrimer interaction site [polypeptide binding]; other site 498761003490 zinc binding site [ion binding]; other site 498761003491 CDP-binding sites; other site 498761003492 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 498761003493 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 498761003494 HIGH motif; other site 498761003495 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 498761003496 active site 498761003497 KMSKS motif; other site 498761003498 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 498761003499 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 498761003500 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 498761003501 trimer interface [polypeptide binding]; other site 498761003502 active site 498761003503 substrate binding site [chemical binding]; other site 498761003504 CoA binding site [chemical binding]; other site 498761003505 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 498761003506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 498761003507 active site 498761003508 HIGH motif; other site 498761003509 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 498761003510 KMSKS motif; other site 498761003511 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 498761003512 tRNA binding surface [nucleotide binding]; other site 498761003513 anticodon binding site; other site 498761003514 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 498761003515 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 498761003516 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 498761003517 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 498761003518 YacP-like NYN domain; Region: NYN_YacP; pfam05991 498761003519 RNA polymerase factor sigma-70; Validated; Region: PRK08295 498761003520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761003521 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 498761003522 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 498761003523 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 498761003524 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 498761003525 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 498761003526 putative homodimer interface [polypeptide binding]; other site 498761003527 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 498761003528 heterodimer interface [polypeptide binding]; other site 498761003529 homodimer interface [polypeptide binding]; other site 498761003530 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 498761003531 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 498761003532 23S rRNA interface [nucleotide binding]; other site 498761003533 L7/L12 interface [polypeptide binding]; other site 498761003534 putative thiostrepton binding site; other site 498761003535 L25 interface [polypeptide binding]; other site 498761003536 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 498761003537 mRNA/rRNA interface [nucleotide binding]; other site 498761003538 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 498761003539 23S rRNA interface [nucleotide binding]; other site 498761003540 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 498761003541 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 498761003542 peripheral dimer interface [polypeptide binding]; other site 498761003543 core dimer interface [polypeptide binding]; other site 498761003544 L10 interface [polypeptide binding]; other site 498761003545 L11 interface [polypeptide binding]; other site 498761003546 putative EF-Tu interaction site [polypeptide binding]; other site 498761003547 putative EF-G interaction site [polypeptide binding]; other site 498761003548 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 498761003549 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 498761003550 RPB12 interaction site [polypeptide binding]; other site 498761003551 RPB1 interaction site [polypeptide binding]; other site 498761003552 RPB10 interaction site [polypeptide binding]; other site 498761003553 RPB11 interaction site [polypeptide binding]; other site 498761003554 RPB3 interaction site [polypeptide binding]; other site 498761003555 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 498761003556 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 498761003557 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 498761003558 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 498761003559 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 498761003560 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 498761003561 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 498761003562 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 498761003563 G-loop; other site 498761003564 DNA binding site [nucleotide binding] 498761003565 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 498761003566 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 498761003567 S17 interaction site [polypeptide binding]; other site 498761003568 S8 interaction site; other site 498761003569 16S rRNA interaction site [nucleotide binding]; other site 498761003570 streptomycin interaction site [chemical binding]; other site 498761003571 23S rRNA interaction site [nucleotide binding]; other site 498761003572 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 498761003573 30S ribosomal protein S7; Validated; Region: PRK05302 498761003574 elongation factor G; Reviewed; Region: PRK00007 498761003575 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 498761003576 G1 box; other site 498761003577 putative GEF interaction site [polypeptide binding]; other site 498761003578 GTP/Mg2+ binding site [chemical binding]; other site 498761003579 Switch I region; other site 498761003580 G2 box; other site 498761003581 G3 box; other site 498761003582 Switch II region; other site 498761003583 G4 box; other site 498761003584 G5 box; other site 498761003585 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 498761003586 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 498761003587 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 498761003588 elongation factor Tu; Reviewed; Region: PRK00049 498761003589 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 498761003590 G1 box; other site 498761003591 GEF interaction site [polypeptide binding]; other site 498761003592 GTP/Mg2+ binding site [chemical binding]; other site 498761003593 Switch I region; other site 498761003594 G2 box; other site 498761003595 G3 box; other site 498761003596 Switch II region; other site 498761003597 G4 box; other site 498761003598 G5 box; other site 498761003599 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 498761003600 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 498761003601 Antibiotic Binding Site [chemical binding]; other site 498761003602 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 498761003603 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 498761003604 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 498761003605 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 498761003606 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 498761003607 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 498761003608 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 498761003609 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 498761003610 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 498761003611 putative translocon binding site; other site 498761003612 protein-rRNA interface [nucleotide binding]; other site 498761003613 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 498761003614 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 498761003615 G-X-X-G motif; other site 498761003616 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 498761003617 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 498761003618 23S rRNA interface [nucleotide binding]; other site 498761003619 5S rRNA interface [nucleotide binding]; other site 498761003620 putative antibiotic binding site [chemical binding]; other site 498761003621 L25 interface [polypeptide binding]; other site 498761003622 L27 interface [polypeptide binding]; other site 498761003623 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 498761003624 23S rRNA interface [nucleotide binding]; other site 498761003625 putative translocon interaction site; other site 498761003626 signal recognition particle (SRP54) interaction site; other site 498761003627 L23 interface [polypeptide binding]; other site 498761003628 trigger factor interaction site; other site 498761003629 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 498761003630 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 498761003631 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 498761003632 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 498761003633 RNA binding site [nucleotide binding]; other site 498761003634 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 498761003635 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 498761003636 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 498761003637 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 498761003638 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 498761003639 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 498761003640 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 498761003641 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 498761003642 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 498761003643 23S rRNA interface [nucleotide binding]; other site 498761003644 L21e interface [polypeptide binding]; other site 498761003645 5S rRNA interface [nucleotide binding]; other site 498761003646 L27 interface [polypeptide binding]; other site 498761003647 L5 interface [polypeptide binding]; other site 498761003648 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 498761003649 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 498761003650 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 498761003651 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 498761003652 23S rRNA binding site [nucleotide binding]; other site 498761003653 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 498761003654 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 498761003655 SecY translocase; Region: SecY; pfam00344 498761003656 adenylate kinase; Reviewed; Region: adk; PRK00279 498761003657 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 498761003658 AMP-binding site [chemical binding]; other site 498761003659 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 498761003660 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 498761003661 active site 498761003662 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 498761003663 RNA binding site [nucleotide binding]; other site 498761003664 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 498761003665 rRNA binding site [nucleotide binding]; other site 498761003666 predicted 30S ribosome binding site; other site 498761003667 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 498761003668 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 498761003669 30S ribosomal protein S13; Region: bact_S13; TIGR03631 498761003670 30S ribosomal protein S11; Validated; Region: PRK05309 498761003671 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 498761003672 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 498761003673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761003674 RNA binding surface [nucleotide binding]; other site 498761003675 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 498761003676 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 498761003677 alphaNTD - beta interaction site [polypeptide binding]; other site 498761003678 alphaNTD homodimer interface [polypeptide binding]; other site 498761003679 alphaNTD - beta' interaction site [polypeptide binding]; other site 498761003680 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 498761003681 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 498761003682 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 498761003683 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761003684 Walker A/P-loop; other site 498761003685 ATP binding site [chemical binding]; other site 498761003686 Q-loop/lid; other site 498761003687 ABC transporter signature motif; other site 498761003688 Walker B; other site 498761003689 D-loop; other site 498761003690 H-loop/switch region; other site 498761003691 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 498761003692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761003693 Walker A/P-loop; other site 498761003694 ATP binding site [chemical binding]; other site 498761003695 Q-loop/lid; other site 498761003696 ABC transporter signature motif; other site 498761003697 Walker B; other site 498761003698 D-loop; other site 498761003699 H-loop/switch region; other site 498761003700 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 498761003701 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 498761003702 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 498761003703 dimerization interface 3.5A [polypeptide binding]; other site 498761003704 active site 498761003705 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 498761003706 23S rRNA interface [nucleotide binding]; other site 498761003707 L3 interface [polypeptide binding]; other site 498761003708 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 498761003709 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 498761003710 putative CheA interaction surface; other site 498761003711 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 498761003712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761003713 putative binding surface; other site 498761003714 active site 498761003715 P2 response regulator binding domain; Region: P2; pfam07194 498761003716 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 498761003717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761003718 ATP binding site [chemical binding]; other site 498761003719 Mg2+ binding site [ion binding]; other site 498761003720 G-X-G motif; other site 498761003721 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 498761003722 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761003723 anti sigma factor interaction site; other site 498761003724 regulatory phosphorylation site [posttranslational modification]; other site 498761003725 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498761003726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498761003727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761003728 dimerization interface [polypeptide binding]; other site 498761003729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761003730 dimer interface [polypeptide binding]; other site 498761003731 putative CheW interface [polypeptide binding]; other site 498761003732 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 498761003733 cyclase homology domain; Region: CHD; cd07302 498761003734 nucleotidyl binding site; other site 498761003735 metal binding site [ion binding]; metal-binding site 498761003736 dimer interface [polypeptide binding]; other site 498761003737 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 498761003738 metal binding triad [ion binding]; metal-binding site 498761003739 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 498761003740 oligomerisation interface [polypeptide binding]; other site 498761003741 mobile loop; other site 498761003742 roof hairpin; other site 498761003743 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 498761003744 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 498761003745 ring oligomerisation interface [polypeptide binding]; other site 498761003746 ATP/Mg binding site [chemical binding]; other site 498761003747 stacking interactions; other site 498761003748 hinge regions; other site 498761003749 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498761003750 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498761003751 active site 498761003752 metal binding site [ion binding]; metal-binding site 498761003753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 498761003754 hypothetical protein; Provisional; Region: PRK03881 498761003755 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 498761003756 AMMECR1; Region: AMMECR1; pfam01871 498761003757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761003758 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498761003759 FeS/SAM binding site; other site 498761003760 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 498761003761 EamA-like transporter family; Region: EamA; pfam00892 498761003762 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 498761003763 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 498761003764 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 498761003765 heterotetramer interface [polypeptide binding]; other site 498761003766 active site pocket [active] 498761003767 cleavage site 498761003768 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 498761003769 feedback inhibition sensing region; other site 498761003770 homohexameric interface [polypeptide binding]; other site 498761003771 nucleotide binding site [chemical binding]; other site 498761003772 N-acetyl-L-glutamate binding site [chemical binding]; other site 498761003773 acetylornithine aminotransferase; Provisional; Region: PRK02627 498761003774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 498761003775 inhibitor-cofactor binding pocket; inhibition site 498761003776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761003777 catalytic residue [active] 498761003778 carbamoyl-phosphate synthase arginine-specific small subunit; Provisional; Region: carA; CHL00197 498761003779 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 498761003780 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 498761003781 catalytic site [active] 498761003782 subunit interface [polypeptide binding]; other site 498761003783 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 498761003784 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498761003785 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498761003786 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 498761003787 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498761003788 ATP-grasp domain; Region: ATP-grasp_4; cl17255 498761003789 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 498761003790 IMP binding site; other site 498761003791 dimer interface [polypeptide binding]; other site 498761003792 interdomain contacts; other site 498761003793 partial ornithine binding site; other site 498761003794 ornithine carbamoyltransferase; Provisional; Region: PRK00779 498761003795 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498761003796 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498761003797 argininosuccinate synthase; Provisional; Region: PRK13820 498761003798 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 498761003799 ANP binding site [chemical binding]; other site 498761003800 Substrate Binding Site II [chemical binding]; other site 498761003801 Substrate Binding Site I [chemical binding]; other site 498761003802 Transposase domain (DUF772); Region: DUF772; pfam05598 498761003803 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761003804 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761003805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 498761003806 Integrase core domain; Region: rve; pfam00665 498761003807 Integrase core domain; Region: rve_3; cl15866 498761003808 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 498761003809 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 498761003810 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 498761003811 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 498761003812 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498761003813 LytTr DNA-binding domain; Region: LytTR; pfam04397 498761003814 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 498761003815 FAD binding site [chemical binding]; other site 498761003816 adenine phosphoribosyltransferase; Provisional; Region: PRK08558 498761003817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761003818 active site 498761003819 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 498761003820 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 498761003821 catalytic residues [active] 498761003822 catalytic nucleophile [active] 498761003823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 498761003824 Probable transposase; Region: OrfB_IS605; pfam01385 498761003825 TPR repeat; Region: TPR_11; pfam13414 498761003826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761003827 binding surface 498761003828 TPR motif; other site 498761003829 TPR repeat; Region: TPR_11; pfam13414 498761003830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498761003831 MarR family; Region: MarR_2; pfam12802 498761003832 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 498761003833 argininosuccinate lyase; Provisional; Region: PRK00855 498761003834 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 498761003835 active sites [active] 498761003836 tetramer interface [polypeptide binding]; other site 498761003837 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498761003838 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498761003839 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498761003840 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 498761003841 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761003842 acyl-activating enzyme (AAE) consensus motif; other site 498761003843 AMP binding site [chemical binding]; other site 498761003844 active site 498761003845 CoA binding site [chemical binding]; other site 498761003846 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 498761003847 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761003848 dimer interface [polypeptide binding]; other site 498761003849 PYR/PP interface [polypeptide binding]; other site 498761003850 TPP binding site [chemical binding]; other site 498761003851 substrate binding site [chemical binding]; other site 498761003852 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 498761003853 TPP-binding site; other site 498761003854 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 498761003855 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 498761003856 Putative amidase domain; Region: Amidase_6; pfam12671 498761003857 isocitrate dehydrogenase; Validated; Region: PRK07362 498761003858 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 498761003859 malate dehydrogenase; Reviewed; Region: PRK06223 498761003860 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 498761003861 NAD(P) binding site [chemical binding]; other site 498761003862 dimer interface [polypeptide binding]; other site 498761003863 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498761003864 substrate binding site [chemical binding]; other site 498761003865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761003866 putative DNA binding site [nucleotide binding]; other site 498761003867 dimerization interface [polypeptide binding]; other site 498761003868 Predicted transcriptional regulator [Transcription]; Region: COG2345 498761003869 putative Zn2+ binding site [ion binding]; other site 498761003870 V4R domain; Region: V4R; cl15268 498761003871 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498761003872 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 498761003873 DNA binding residues [nucleotide binding] 498761003874 B12 binding domain; Region: B12-binding_2; pfam02607 498761003875 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 498761003876 B12 binding site [chemical binding]; other site 498761003877 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 498761003878 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 498761003879 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 498761003880 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 498761003881 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 498761003882 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 498761003883 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 498761003884 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 498761003885 putative substrate-binding site; other site 498761003886 nickel binding site [ion binding]; other site 498761003887 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 498761003888 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 498761003889 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761003890 Acylphosphatase; Region: Acylphosphatase; pfam00708 498761003891 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 498761003892 HypF finger; Region: zf-HYPF; pfam07503 498761003893 HypF finger; Region: zf-HYPF; pfam07503 498761003894 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 498761003895 HupF/HypC family; Region: HupF_HypC; pfam01455 498761003896 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 498761003897 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 498761003898 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 498761003899 dimerization interface [polypeptide binding]; other site 498761003900 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 498761003901 ATP binding site [chemical binding]; other site 498761003902 intracellular protease, PfpI family; Region: PfpI; TIGR01382 498761003903 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 498761003904 conserved cys residue [active] 498761003905 Uncharacterized conserved protein [Function unknown]; Region: COG0432 498761003906 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 498761003907 putative FMN binding site [chemical binding]; other site 498761003908 Uncharacterized conserved protein [Function unknown]; Region: COG1434 498761003909 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 498761003910 putative active site [active] 498761003911 PAS domain; Region: PAS_8; pfam13188 498761003912 PAS fold; Region: PAS_4; pfam08448 498761003913 HD domain; Region: HD; pfam01966 498761003914 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 498761003915 homodimer interface [polypeptide binding]; other site 498761003916 metal binding site [ion binding]; metal-binding site 498761003917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498761003918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498761003919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 498761003920 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 498761003921 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761003922 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 498761003923 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498761003924 Walker A/P-loop; other site 498761003925 ATP binding site [chemical binding]; other site 498761003926 Q-loop/lid; other site 498761003927 ABC transporter signature motif; other site 498761003928 Walker B; other site 498761003929 D-loop; other site 498761003930 H-loop/switch region; other site 498761003931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498761003932 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498761003933 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 498761003934 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 498761003935 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 498761003936 flagellar motor protein MotA; Validated; Region: PRK08124 498761003937 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 498761003938 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 498761003939 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 498761003940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 498761003941 ligand binding site [chemical binding]; other site 498761003942 Transposase domain (DUF772); Region: DUF772; pfam05598 498761003943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761003944 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761003945 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498761003946 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 498761003947 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 498761003948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 498761003949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761003950 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 498761003951 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 498761003952 homodimer interface [polypeptide binding]; other site 498761003953 substrate-cofactor binding pocket; other site 498761003954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761003955 catalytic residue [active] 498761003956 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 498761003957 6-phosphogluconate dehydratase; Region: edd; TIGR01196 498761003958 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 498761003959 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 498761003960 putative valine binding site [chemical binding]; other site 498761003961 dimer interface [polypeptide binding]; other site 498761003962 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 498761003963 ketol-acid reductoisomerase; Provisional; Region: PRK05479 498761003964 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 498761003965 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 498761003966 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 498761003967 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 498761003968 PYR/PP interface [polypeptide binding]; other site 498761003969 dimer interface [polypeptide binding]; other site 498761003970 TPP binding site [chemical binding]; other site 498761003971 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 498761003972 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 498761003973 TPP-binding site [chemical binding]; other site 498761003974 dimer interface [polypeptide binding]; other site 498761003975 2-isopropylmalate synthase; Validated; Region: PRK00915 498761003976 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 498761003977 active site 498761003978 catalytic residues [active] 498761003979 metal binding site [ion binding]; metal-binding site 498761003980 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 498761003981 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 498761003982 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 498761003983 substrate binding site [chemical binding]; other site 498761003984 ligand binding site [chemical binding]; other site 498761003985 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 498761003986 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 498761003987 substrate binding site [chemical binding]; other site 498761003988 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 498761003989 tartrate dehydrogenase; Region: TTC; TIGR02089 498761003990 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 498761003991 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 498761003992 active site 498761003993 catalytic residues [active] 498761003994 metal binding site [ion binding]; metal-binding site 498761003995 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 498761003996 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 498761003997 Uncharacterized conserved protein [Function unknown]; Region: COG1624 498761003998 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 498761003999 YbbR-like protein; Region: YbbR; pfam07949 498761004000 YbbR-like protein; Region: YbbR; pfam07949 498761004001 YbbR-like protein; Region: YbbR; pfam07949 498761004002 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 498761004003 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 498761004004 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 498761004005 active site 498761004006 substrate binding site [chemical binding]; other site 498761004007 metal binding site [ion binding]; metal-binding site 498761004008 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 498761004009 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 498761004010 glutaminase active site [active] 498761004011 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 498761004012 dimer interface [polypeptide binding]; other site 498761004013 active site 498761004014 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 498761004015 dimer interface [polypeptide binding]; other site 498761004016 active site 498761004017 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 498761004018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761004019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498761004020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498761004021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498761004022 dimerization interface [polypeptide binding]; other site 498761004023 Rubrerythrin [Energy production and conversion]; Region: COG1592 498761004024 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 498761004025 iron binding site [ion binding]; other site 498761004026 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 498761004027 Rubrerythrin [Energy production and conversion]; Region: COG1592 498761004028 diiron binding motif [ion binding]; other site 498761004029 SNF2 Helicase protein; Region: DUF3670; pfam12419 498761004030 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498761004031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761004032 ATP binding site [chemical binding]; other site 498761004033 putative Mg++ binding site [ion binding]; other site 498761004034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761004035 nucleotide binding region [chemical binding]; other site 498761004036 ATP-binding site [chemical binding]; other site 498761004037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004039 active site 498761004040 phosphorylation site [posttranslational modification] 498761004041 intermolecular recognition site; other site 498761004042 dimerization interface [polypeptide binding]; other site 498761004043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761004044 DNA binding site [nucleotide binding] 498761004045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004046 dimer interface [polypeptide binding]; other site 498761004047 phosphorylation site [posttranslational modification] 498761004048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004049 ATP binding site [chemical binding]; other site 498761004050 Mg2+ binding site [ion binding]; other site 498761004051 G-X-G motif; other site 498761004052 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 498761004053 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761004054 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 498761004055 Protein export membrane protein; Region: SecD_SecF; cl14618 498761004056 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 498761004057 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 498761004058 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 498761004059 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498761004060 amino acid carrier protein; Region: agcS; TIGR00835 498761004061 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 498761004062 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 498761004063 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 498761004064 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498761004065 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 498761004066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761004067 Walker A/P-loop; other site 498761004068 ATP binding site [chemical binding]; other site 498761004069 Q-loop/lid; other site 498761004070 ABC transporter signature motif; other site 498761004071 Walker B; other site 498761004072 D-loop; other site 498761004073 H-loop/switch region; other site 498761004074 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 498761004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761004076 dimer interface [polypeptide binding]; other site 498761004077 conserved gate region; other site 498761004078 putative PBP binding loops; other site 498761004079 ABC-ATPase subunit interface; other site 498761004080 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 498761004081 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 498761004082 YibE/F-like protein; Region: YibE_F; pfam07907 498761004083 Transposase; Region: DEDD_Tnp_IS110; pfam01548 498761004084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 498761004085 putative transposase OrfB; Reviewed; Region: PHA02517 498761004086 HTH-like domain; Region: HTH_21; pfam13276 498761004087 Integrase core domain; Region: rve; pfam00665 498761004088 Integrase core domain; Region: rve_3; pfam13683 498761004089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498761004090 Transposase; Region: HTH_Tnp_1; pfam01527 498761004091 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004092 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004093 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004094 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004095 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004096 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004097 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004098 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004099 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 498761004100 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004101 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004102 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004103 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004104 AAA domain; Region: AAA_22; pfam13401 498761004105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761004106 Walker A motif; other site 498761004107 ATP binding site [chemical binding]; other site 498761004108 Walker B motif; other site 498761004109 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 498761004110 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 498761004111 Protein export membrane protein; Region: SecD_SecF; cl14618 498761004112 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 498761004113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 498761004114 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761004115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498761004116 MarR family; Region: MarR; pfam01047 498761004117 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 498761004118 EamA-like transporter family; Region: EamA; pfam00892 498761004119 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 498761004120 EamA-like transporter family; Region: EamA; pfam00892 498761004121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004122 dimer interface [polypeptide binding]; other site 498761004123 phosphorylation site [posttranslational modification] 498761004124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004125 ATP binding site [chemical binding]; other site 498761004126 Mg2+ binding site [ion binding]; other site 498761004127 G-X-G motif; other site 498761004128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761004129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004130 active site 498761004131 phosphorylation site [posttranslational modification] 498761004132 intermolecular recognition site; other site 498761004133 dimerization interface [polypeptide binding]; other site 498761004134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761004135 DNA binding site [nucleotide binding] 498761004136 aconitate hydratase 2; Region: acnB; TIGR00117 498761004137 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 498761004138 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 498761004139 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761004140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761004141 metal binding site [ion binding]; metal-binding site 498761004142 active site 498761004143 I-site; other site 498761004144 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761004145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761004146 Zn2+ binding site [ion binding]; other site 498761004147 Mg2+ binding site [ion binding]; other site 498761004148 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 498761004149 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 498761004150 active site 498761004151 metal binding site [ion binding]; metal-binding site 498761004152 DNA binding site [nucleotide binding] 498761004153 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 498761004154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761004155 AAA domain; Region: AAA_23; pfam13476 498761004156 Walker A/P-loop; other site 498761004157 ATP binding site [chemical binding]; other site 498761004158 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 498761004159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761004160 ABC transporter signature motif; other site 498761004161 Walker B; other site 498761004162 D-loop; other site 498761004163 H-loop/switch region; other site 498761004164 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 498761004165 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 498761004166 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 498761004167 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761004168 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498761004169 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761004170 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761004171 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 498761004172 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 498761004173 amphipathic channel; other site 498761004174 Asn-Pro-Ala signature motifs; other site 498761004175 glycerol kinase; Provisional; Region: glpK; PRK00047 498761004176 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 498761004177 N- and C-terminal domain interface [polypeptide binding]; other site 498761004178 active site 498761004179 MgATP binding site [chemical binding]; other site 498761004180 catalytic site [active] 498761004181 metal binding site [ion binding]; metal-binding site 498761004182 glycerol binding site [chemical binding]; other site 498761004183 homotetramer interface [polypeptide binding]; other site 498761004184 homodimer interface [polypeptide binding]; other site 498761004185 FBP binding site [chemical binding]; other site 498761004186 protein IIAGlc interface [polypeptide binding]; other site 498761004187 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 498761004188 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498761004189 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 498761004190 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 498761004191 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 498761004192 Cysteine-rich domain; Region: CCG; pfam02754 498761004193 Cysteine-rich domain; Region: CCG; pfam02754 498761004194 pyruvate kinase; Provisional; Region: PRK06354 498761004195 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 498761004196 domain interfaces; other site 498761004197 active site 498761004198 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 498761004199 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 498761004200 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 498761004201 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 498761004202 Phosphoglycerate kinase; Region: PGK; pfam00162 498761004203 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 498761004204 substrate binding site [chemical binding]; other site 498761004205 hinge regions; other site 498761004206 ADP binding site [chemical binding]; other site 498761004207 catalytic site [active] 498761004208 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 498761004209 triosephosphate isomerase; Provisional; Region: PRK14565 498761004210 substrate binding site [chemical binding]; other site 498761004211 dimer interface [polypeptide binding]; other site 498761004212 catalytic triad [active] 498761004213 enolase; Provisional; Region: eno; PRK00077 498761004214 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 498761004215 dimer interface [polypeptide binding]; other site 498761004216 metal binding site [ion binding]; metal-binding site 498761004217 substrate binding pocket [chemical binding]; other site 498761004218 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761004219 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761004220 dimer interface [polypeptide binding]; other site 498761004221 putative CheW interface [polypeptide binding]; other site 498761004222 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 498761004223 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 498761004224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 498761004225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004226 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 498761004227 putative active site [active] 498761004228 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 498761004229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004230 putative active site [active] 498761004231 heme pocket [chemical binding]; other site 498761004232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004233 putative active site [active] 498761004234 heme pocket [chemical binding]; other site 498761004235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004236 putative active site [active] 498761004237 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 498761004238 heme pocket [chemical binding]; other site 498761004239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004240 dimer interface [polypeptide binding]; other site 498761004241 phosphorylation site [posttranslational modification] 498761004242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004243 ATP binding site [chemical binding]; other site 498761004244 Mg2+ binding site [ion binding]; other site 498761004245 G-X-G motif; other site 498761004246 Response regulator receiver domain; Region: Response_reg; pfam00072 498761004247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004248 active site 498761004249 phosphorylation site [posttranslational modification] 498761004250 intermolecular recognition site; other site 498761004251 dimerization interface [polypeptide binding]; other site 498761004252 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 498761004253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761004254 motif II; other site 498761004255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498761004256 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498761004257 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 498761004258 active site 498761004259 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 498761004260 4Fe-4S binding domain; Region: Fer4; pfam00037 498761004261 4Fe-4S binding domain; Region: Fer4_6; pfam12837 498761004262 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498761004263 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004264 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004265 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004266 PAS domain S-box; Region: sensory_box; TIGR00229 498761004267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004268 putative active site [active] 498761004269 heme pocket [chemical binding]; other site 498761004270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 498761004271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004272 dimer interface [polypeptide binding]; other site 498761004273 phosphorylation site [posttranslational modification] 498761004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004275 ATP binding site [chemical binding]; other site 498761004276 Mg2+ binding site [ion binding]; other site 498761004277 G-X-G motif; other site 498761004278 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 498761004279 metal binding site [ion binding]; metal-binding site 498761004280 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 498761004281 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 498761004282 active site 498761004283 catalytic triad [active] 498761004284 oxyanion hole [active] 498761004285 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 498761004286 FMN binding site [chemical binding]; other site 498761004287 dimer interface [polypeptide binding]; other site 498761004288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498761004289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004290 ATP binding site [chemical binding]; other site 498761004291 Mg2+ binding site [ion binding]; other site 498761004292 G-X-G motif; other site 498761004293 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761004294 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761004295 putative active site [active] 498761004296 putative NTP binding site [chemical binding]; other site 498761004297 putative nucleic acid binding site [nucleotide binding]; other site 498761004298 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761004299 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 498761004300 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761004301 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 498761004302 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 498761004303 AIR carboxylase; Region: AIRC; smart01001 498761004304 hypothetical protein; Provisional; Region: PRK04194 498761004305 Protein of unknown function DUF111; Region: DUF111; cl03398 498761004306 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 498761004307 aspartate aminotransferase; Provisional; Region: PRK06836 498761004308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761004309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761004310 homodimer interface [polypeptide binding]; other site 498761004311 catalytic residue [active] 498761004312 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 498761004313 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 498761004314 catalytic residues [active] 498761004315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761004316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004317 active site 498761004318 phosphorylation site [posttranslational modification] 498761004319 intermolecular recognition site; other site 498761004320 dimerization interface [polypeptide binding]; other site 498761004321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761004322 DNA binding site [nucleotide binding] 498761004323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498761004324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004325 dimer interface [polypeptide binding]; other site 498761004326 phosphorylation site [posttranslational modification] 498761004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004328 ATP binding site [chemical binding]; other site 498761004329 Mg2+ binding site [ion binding]; other site 498761004330 G-X-G motif; other site 498761004331 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498761004332 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 498761004333 Walker A/P-loop; other site 498761004334 ATP binding site [chemical binding]; other site 498761004335 Q-loop/lid; other site 498761004336 ABC transporter signature motif; other site 498761004337 Walker B; other site 498761004338 D-loop; other site 498761004339 H-loop/switch region; other site 498761004340 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498761004341 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498761004342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004343 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004345 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004346 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 498761004347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498761004348 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 498761004349 active site 498761004350 metal binding site [ion binding]; metal-binding site 498761004351 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 498761004352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498761004353 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004354 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004355 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004356 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 498761004357 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 498761004358 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 498761004359 transmembrane helices; other site 498761004360 Uncharacterized conserved protein [Function unknown]; Region: COG1284 498761004361 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498761004362 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 498761004363 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498761004364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761004365 dimerization interface [polypeptide binding]; other site 498761004366 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761004367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761004368 dimer interface [polypeptide binding]; other site 498761004369 putative CheW interface [polypeptide binding]; other site 498761004370 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 498761004371 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761004372 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761004373 putative active site [active] 498761004374 putative NTP binding site [chemical binding]; other site 498761004375 putative nucleic acid binding site [nucleotide binding]; other site 498761004376 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761004377 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 498761004378 Protein of unknown function (DUF445); Region: DUF445; pfam04286 498761004379 Protein of unknown function (DUF445); Region: DUF445; pfam04286 498761004380 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498761004381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004382 dimer interface [polypeptide binding]; other site 498761004383 phosphorylation site [posttranslational modification] 498761004384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004385 ATP binding site [chemical binding]; other site 498761004386 Mg2+ binding site [ion binding]; other site 498761004387 G-X-G motif; other site 498761004388 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 498761004389 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498761004390 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 498761004391 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 498761004392 G1 box; other site 498761004393 putative GEF interaction site [polypeptide binding]; other site 498761004394 GTP/Mg2+ binding site [chemical binding]; other site 498761004395 Switch I region; other site 498761004396 G2 box; other site 498761004397 G3 box; other site 498761004398 Switch II region; other site 498761004399 G4 box; other site 498761004400 G5 box; other site 498761004401 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 498761004402 Uncharacterized conserved protein [Function unknown]; Region: COG0398 498761004403 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498761004404 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 498761004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 498761004406 Mg2+ binding site [ion binding]; other site 498761004407 G-X-G motif; other site 498761004408 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 498761004409 Carbon starvation protein CstA; Region: CstA; pfam02554 498761004410 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 498761004411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004412 Response regulator receiver domain; Region: Response_reg; pfam00072 498761004413 active site 498761004414 phosphorylation site [posttranslational modification] 498761004415 intermolecular recognition site; other site 498761004416 dimerization interface [polypeptide binding]; other site 498761004417 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498761004418 LytTr DNA-binding domain; Region: LytTR; smart00850 498761004419 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 498761004420 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 498761004421 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 498761004422 Histidine kinase; Region: His_kinase; pfam06580 498761004423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004424 ATP binding site [chemical binding]; other site 498761004425 Mg2+ binding site [ion binding]; other site 498761004426 G-X-G motif; other site 498761004427 biotin synthase; Region: bioB; TIGR00433 498761004428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761004429 FeS/SAM binding site; other site 498761004430 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 498761004431 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 498761004432 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 498761004433 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 498761004434 dimer interface [polypeptide binding]; other site 498761004435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761004436 catalytic residue [active] 498761004437 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498761004438 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 498761004439 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 498761004440 Ligand Binding Site [chemical binding]; other site 498761004441 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 498761004442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498761004443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498761004444 Walker A/P-loop; other site 498761004445 ATP binding site [chemical binding]; other site 498761004446 Q-loop/lid; other site 498761004447 ABC transporter signature motif; other site 498761004448 Walker B; other site 498761004449 D-loop; other site 498761004450 H-loop/switch region; other site 498761004451 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498761004452 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 498761004453 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 498761004454 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 498761004455 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 498761004456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498761004457 metal-binding site [ion binding] 498761004458 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 498761004459 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498761004460 metal-binding site [ion binding] 498761004461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498761004462 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498761004463 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 498761004464 putative homodimer interface [polypeptide binding]; other site 498761004465 putative homotetramer interface [polypeptide binding]; other site 498761004466 putative allosteric switch controlling residues; other site 498761004467 putative metal binding site [ion binding]; other site 498761004468 putative homodimer-homodimer interface [polypeptide binding]; other site 498761004469 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 498761004470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004471 ATP binding site [chemical binding]; other site 498761004472 Mg2+ binding site [ion binding]; other site 498761004473 G-X-G motif; other site 498761004474 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 498761004475 putative CheA interaction surface; other site 498761004476 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 498761004477 Uncharacterized conserved protein [Function unknown]; Region: COG0062 498761004478 putative carbohydrate kinase; Provisional; Region: PRK10565 498761004479 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 498761004480 putative substrate binding site [chemical binding]; other site 498761004481 putative ATP binding site [chemical binding]; other site 498761004482 FOG: CBS domain [General function prediction only]; Region: COG0517 498761004483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 498761004484 alanine racemase; Reviewed; Region: alr; PRK00053 498761004485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 498761004486 active site 498761004487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498761004488 dimer interface [polypeptide binding]; other site 498761004489 substrate binding site [chemical binding]; other site 498761004490 catalytic residues [active] 498761004491 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 498761004492 PemK-like protein; Region: PemK; pfam02452 498761004493 Peptidase C26; Region: Peptidase_C26; pfam07722 498761004494 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 498761004495 catalytic triad [active] 498761004496 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498761004497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761004498 Zn2+ binding site [ion binding]; other site 498761004499 Mg2+ binding site [ion binding]; other site 498761004500 L-asparaginase II; Region: Asparaginase_II; pfam06089 498761004501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498761004502 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 498761004503 Amidohydrolase; Region: Amidohydro_4; pfam13147 498761004504 active site 498761004505 Response regulator receiver domain; Region: Response_reg; pfam00072 498761004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004507 active site 498761004508 phosphorylation site [posttranslational modification] 498761004509 intermolecular recognition site; other site 498761004510 dimerization interface [polypeptide binding]; other site 498761004511 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 498761004512 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 498761004513 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 498761004514 Glycoprotease family; Region: Peptidase_M22; pfam00814 498761004515 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 498761004516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498761004517 Coenzyme A binding pocket [chemical binding]; other site 498761004518 FOG: CBS domain [General function prediction only]; Region: COG0517 498761004519 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498761004520 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 498761004521 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 498761004522 substrate binding pocket [chemical binding]; other site 498761004523 dimer interface [polypeptide binding]; other site 498761004524 inhibitor binding site; inhibition site 498761004525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761004526 S-adenosylmethionine binding site [chemical binding]; other site 498761004527 UGMP family protein; Validated; Region: PRK09604 498761004528 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 498761004529 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 498761004530 intersubunit interface [polypeptide binding]; other site 498761004531 active site 498761004532 Zn2+ binding site [ion binding]; other site 498761004533 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 498761004534 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498761004535 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 498761004536 metal-dependent hydrolase; Provisional; Region: PRK00685 498761004537 cystathionine gamma-synthase; Reviewed; Region: PRK08247 498761004538 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498761004539 homodimer interface [polypeptide binding]; other site 498761004540 substrate-cofactor binding pocket; other site 498761004541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761004542 catalytic residue [active] 498761004543 cystathionine beta-lyase; Provisional; Region: PRK08064 498761004544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498761004545 homodimer interface [polypeptide binding]; other site 498761004546 substrate-cofactor binding pocket; other site 498761004547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761004548 catalytic residue [active] 498761004549 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 498761004550 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 498761004551 dimer interface [polypeptide binding]; other site 498761004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761004553 catalytic residue [active] 498761004554 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 498761004555 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 498761004556 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 498761004557 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 498761004558 Transcriptional regulator PadR-like family; Region: PadR; cl17335 498761004559 Predicted transcriptional regulators [Transcription]; Region: COG1695 498761004560 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004561 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004562 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004563 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 498761004564 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 498761004565 CoA binding domain; Region: CoA_binding; smart00881 498761004566 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 498761004567 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 498761004568 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 498761004569 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 498761004570 putative dimer interface [polypeptide binding]; other site 498761004571 [2Fe-2S] cluster binding site [ion binding]; other site 498761004572 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 498761004573 dimer interface [polypeptide binding]; other site 498761004574 [2Fe-2S] cluster binding site [ion binding]; other site 498761004575 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 498761004576 SLBB domain; Region: SLBB; pfam10531 498761004577 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 498761004578 4Fe-4S binding domain; Region: Fer4; pfam00037 498761004579 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761004580 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 498761004581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498761004582 catalytic loop [active] 498761004583 iron binding site [ion binding]; other site 498761004584 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 498761004585 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 498761004586 [4Fe-4S] binding site [ion binding]; other site 498761004587 molybdopterin cofactor binding site; other site 498761004588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 498761004589 molybdopterin cofactor binding site; other site 498761004590 DNA polymerase I; Provisional; Region: PRK05755 498761004591 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 498761004592 active site 498761004593 metal binding site 1 [ion binding]; metal-binding site 498761004594 putative 5' ssDNA interaction site; other site 498761004595 metal binding site 3; metal-binding site 498761004596 metal binding site 2 [ion binding]; metal-binding site 498761004597 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 498761004598 putative DNA binding site [nucleotide binding]; other site 498761004599 putative metal binding site [ion binding]; other site 498761004600 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 498761004601 active site 498761004602 substrate binding site [chemical binding]; other site 498761004603 catalytic site [active] 498761004604 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 498761004605 active site 498761004606 DNA binding site [nucleotide binding] 498761004607 catalytic site [active] 498761004608 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 498761004609 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 498761004610 DNA binding site [nucleotide binding] 498761004611 catalytic residue [active] 498761004612 H2TH interface [polypeptide binding]; other site 498761004613 putative catalytic residues [active] 498761004614 turnover-facilitating residue; other site 498761004615 intercalation triad [nucleotide binding]; other site 498761004616 8OG recognition residue [nucleotide binding]; other site 498761004617 putative reading head residues; other site 498761004618 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 498761004619 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 498761004620 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498761004621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761004622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761004623 ABC transporter; Region: ABC_tran_2; pfam12848 498761004624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761004625 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 498761004626 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 498761004627 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 498761004628 CoA-binding site [chemical binding]; other site 498761004629 ATP-binding [chemical binding]; other site 498761004630 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 498761004631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 498761004632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 498761004633 catalytic residue [active] 498761004634 Predicted membrane protein [Function unknown]; Region: COG2323 498761004635 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 498761004636 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 498761004637 DXD motif; other site 498761004638 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 498761004639 spermidine synthase; Provisional; Region: PRK00811 498761004640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761004641 S-adenosylmethionine binding site [chemical binding]; other site 498761004642 TspO/MBR family; Region: TspO_MBR; pfam03073 498761004643 NlpC/P60 family; Region: NLPC_P60; cl17555 498761004644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761004645 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 498761004646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761004647 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 498761004648 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 498761004649 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 498761004650 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 498761004651 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 498761004652 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 498761004653 active site 498761004654 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 498761004655 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 498761004656 LysE type translocator; Region: LysE; cl00565 498761004657 Helix-turn-helix domain; Region: HTH_17; pfam12728 498761004658 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 498761004659 synthetase active site [active] 498761004660 NTP binding site [chemical binding]; other site 498761004661 metal binding site [ion binding]; metal-binding site 498761004662 Protein of unknown function (DUF458); Region: DUF458; cl00861 498761004663 YtxC-like family; Region: YtxC; pfam08812 498761004664 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 498761004665 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 498761004666 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 498761004667 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 498761004668 active site 498761004669 dimer interface [polypeptide binding]; other site 498761004670 motif 1; other site 498761004671 motif 2; other site 498761004672 motif 3; other site 498761004673 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 498761004674 anticodon binding site; other site 498761004675 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 498761004676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761004677 acyl-activating enzyme (AAE) consensus motif; other site 498761004678 active site 498761004679 AMP binding site [chemical binding]; other site 498761004680 CoA binding site [chemical binding]; other site 498761004681 Amidohydrolase; Region: Amidohydro_2; pfam04909 498761004682 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 498761004683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761004684 acyl-activating enzyme (AAE) consensus motif; other site 498761004685 AMP binding site [chemical binding]; other site 498761004686 active site 498761004687 CoA binding site [chemical binding]; other site 498761004688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498761004689 TPR motif; other site 498761004690 binding surface 498761004691 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 498761004692 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 498761004693 putative active site; other site 498761004694 catalytic residue [active] 498761004695 3-dehydroquinate synthase; Provisional; Region: PRK02290 498761004696 translation initiation factor IF-3; Region: infC; TIGR00168 498761004697 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 498761004698 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 498761004699 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 498761004700 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 498761004701 23S rRNA binding site [nucleotide binding]; other site 498761004702 L21 binding site [polypeptide binding]; other site 498761004703 L13 binding site [polypeptide binding]; other site 498761004704 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 498761004705 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 498761004706 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 498761004707 TrkA-N domain; Region: TrkA_N; pfam02254 498761004708 TrkA-C domain; Region: TrkA_C; pfam02080 498761004709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 498761004710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 498761004711 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 498761004712 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 498761004713 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 498761004714 dimer interface [polypeptide binding]; other site 498761004715 motif 1; other site 498761004716 active site 498761004717 motif 2; other site 498761004718 motif 3; other site 498761004719 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 498761004720 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 498761004721 putative tRNA-binding site [nucleotide binding]; other site 498761004722 B3/4 domain; Region: B3_4; pfam03483 498761004723 tRNA synthetase B5 domain; Region: B5; smart00874 498761004724 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 498761004725 dimer interface [polypeptide binding]; other site 498761004726 motif 1; other site 498761004727 motif 3; other site 498761004728 motif 2; other site 498761004729 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 498761004730 Cell division protein ZapA; Region: ZapA; cl01146 498761004731 hypothetical protein; Provisional; Region: PRK08609 498761004732 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 498761004733 metal binding triad [ion binding]; metal-binding site 498761004734 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 498761004735 active site 498761004736 Uncharacterized conserved protein [Function unknown]; Region: COG0327 498761004737 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 498761004738 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 498761004739 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 498761004740 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 498761004741 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 498761004742 Peptidase family U32; Region: Peptidase_U32; pfam01136 498761004743 Collagenase; Region: DUF3656; pfam12392 498761004744 Peptidase family U32; Region: Peptidase_U32; pfam01136 498761004745 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 498761004746 MutS domain III; Region: MutS_III; pfam05192 498761004747 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 498761004748 Walker A/P-loop; other site 498761004749 ATP binding site [chemical binding]; other site 498761004750 Q-loop/lid; other site 498761004751 ABC transporter signature motif; other site 498761004752 Walker B; other site 498761004753 D-loop; other site 498761004754 H-loop/switch region; other site 498761004755 Smr domain; Region: Smr; pfam01713 498761004756 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 498761004757 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 498761004758 HAMP domain; Region: HAMP; pfam00672 498761004759 dimerization interface [polypeptide binding]; other site 498761004760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761004761 dimer interface [polypeptide binding]; other site 498761004762 phosphorylation site [posttranslational modification] 498761004763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761004764 ATP binding site [chemical binding]; other site 498761004765 Mg2+ binding site [ion binding]; other site 498761004766 G-X-G motif; other site 498761004767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761004768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004769 active site 498761004770 phosphorylation site [posttranslational modification] 498761004771 intermolecular recognition site; other site 498761004772 dimerization interface [polypeptide binding]; other site 498761004773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761004774 DNA binding site [nucleotide binding] 498761004775 Transglycosylase; Region: Transgly; pfam00912 498761004776 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 498761004777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498761004778 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 498761004779 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 498761004780 active site 498761004781 HIGH motif; other site 498761004782 dimer interface [polypeptide binding]; other site 498761004783 KMSKS motif; other site 498761004784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761004785 RNA binding surface [nucleotide binding]; other site 498761004786 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 498761004787 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 498761004788 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 498761004789 hypothetical protein; Validated; Region: PRK00110 498761004790 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 498761004791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761004792 putative DNA binding site [nucleotide binding]; other site 498761004793 putative Zn2+ binding site [ion binding]; other site 498761004794 AsnC family; Region: AsnC_trans_reg; pfam01037 498761004795 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 498761004796 active site 498761004797 putative DNA-binding cleft [nucleotide binding]; other site 498761004798 dimer interface [polypeptide binding]; other site 498761004799 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 498761004800 RuvA N terminal domain; Region: RuvA_N; pfam01330 498761004801 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 498761004802 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 498761004803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761004804 Walker A motif; other site 498761004805 ATP binding site [chemical binding]; other site 498761004806 Walker B motif; other site 498761004807 arginine finger; other site 498761004808 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 498761004809 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 498761004810 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 498761004811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761004812 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 498761004813 Stage II sporulation protein; Region: SpoIID; pfam08486 498761004814 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 498761004815 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 498761004816 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 498761004817 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 498761004818 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 498761004819 Preprotein translocase subunit; Region: YajC; pfam02699 498761004820 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 498761004821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761004822 Zn2+ binding site [ion binding]; other site 498761004823 Mg2+ binding site [ion binding]; other site 498761004824 protein-export membrane protein SecD; Region: secD; TIGR01129 498761004825 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 498761004826 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 498761004827 Protein export membrane protein; Region: SecD_SecF; pfam02355 498761004828 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498761004829 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 498761004830 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 498761004831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761004832 Zn2+ binding site [ion binding]; other site 498761004833 Mg2+ binding site [ion binding]; other site 498761004834 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 498761004835 synthetase active site [active] 498761004836 NTP binding site [chemical binding]; other site 498761004837 metal binding site [ion binding]; metal-binding site 498761004838 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 498761004839 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 498761004840 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 498761004841 putative active site [active] 498761004842 dimerization interface [polypeptide binding]; other site 498761004843 putative tRNAtyr binding site [nucleotide binding]; other site 498761004844 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761004845 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 498761004846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761004847 FeS/SAM binding site; other site 498761004848 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 498761004849 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 498761004850 dimer interface [polypeptide binding]; other site 498761004851 motif 1; other site 498761004852 active site 498761004853 motif 2; other site 498761004854 motif 3; other site 498761004855 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 498761004856 anticodon binding site; other site 498761004857 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 498761004858 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 498761004859 dimer interface [polypeptide binding]; other site 498761004860 anticodon binding site; other site 498761004861 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 498761004862 homodimer interface [polypeptide binding]; other site 498761004863 motif 1; other site 498761004864 active site 498761004865 motif 2; other site 498761004866 GAD domain; Region: GAD; pfam02938 498761004867 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498761004868 active site 498761004869 motif 3; other site 498761004870 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 498761004871 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 498761004872 putative ATP binding site [chemical binding]; other site 498761004873 putative substrate interface [chemical binding]; other site 498761004874 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 498761004875 putative homodimer interface [polypeptide binding]; other site 498761004876 putative homotetramer interface [polypeptide binding]; other site 498761004877 putative allosteric switch controlling residues; other site 498761004878 putative metal binding site [ion binding]; other site 498761004879 putative homodimer-homodimer interface [polypeptide binding]; other site 498761004880 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498761004881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498761004882 catalytic residues [active] 498761004883 Response regulator receiver domain; Region: Response_reg; pfam00072 498761004884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761004885 active site 498761004886 phosphorylation site [posttranslational modification] 498761004887 intermolecular recognition site; other site 498761004888 dimerization interface [polypeptide binding]; other site 498761004889 PAS domain S-box; Region: sensory_box; TIGR00229 498761004890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004891 putative active site [active] 498761004892 heme pocket [chemical binding]; other site 498761004893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761004894 PAS domain; Region: PAS_9; pfam13426 498761004895 putative active site [active] 498761004896 heme pocket [chemical binding]; other site 498761004897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761004898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761004899 metal binding site [ion binding]; metal-binding site 498761004900 active site 498761004901 I-site; other site 498761004902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498761004903 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 498761004904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761004905 FeS/SAM binding site; other site 498761004906 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 498761004907 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 498761004908 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 498761004909 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 498761004910 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 498761004911 S-layer homology domain; Region: SLH; pfam00395 498761004912 S-layer homology domain; Region: SLH; pfam00395 498761004913 Cobalt transport protein; Region: CbiQ; cl00463 498761004914 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 498761004915 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761004916 Walker A/P-loop; other site 498761004917 ATP binding site [chemical binding]; other site 498761004918 Q-loop/lid; other site 498761004919 ABC transporter signature motif; other site 498761004920 Walker B; other site 498761004921 D-loop; other site 498761004922 H-loop/switch region; other site 498761004923 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761004924 Walker A/P-loop; other site 498761004925 ATP binding site [chemical binding]; other site 498761004926 Q-loop/lid; other site 498761004927 ABC transporter signature motif; other site 498761004928 Walker B; other site 498761004929 D-loop; other site 498761004930 H-loop/switch region; other site 498761004931 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 498761004932 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 498761004933 photolyase PhrII; Region: phr2; TIGR00591 498761004934 DNA photolyase; Region: DNA_photolyase; pfam00875 498761004935 Transcriptional regulator; Region: Rrf2; cl17282 498761004936 Rrf2 family protein; Region: rrf2_super; TIGR00738 498761004937 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 498761004938 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 498761004939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761004940 catalytic residue [active] 498761004941 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 498761004942 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 498761004943 trimerization site [polypeptide binding]; other site 498761004944 active site 498761004945 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 498761004946 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 498761004947 Ligand Binding Site [chemical binding]; other site 498761004948 PRC-barrel domain; Region: PRC; pfam05239 498761004949 PRC-barrel domain; Region: PRC; pfam05239 498761004950 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 498761004951 Domain of unknown function DUF20; Region: UPF0118; pfam01594 498761004952 Transposase domain (DUF772); Region: DUF772; pfam05598 498761004953 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761004954 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761004955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 498761004956 Transposase; Region: DEDD_Tnp_IS110; pfam01548 498761004957 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 498761004958 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 498761004959 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 498761004960 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 498761004961 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 498761004962 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 498761004963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498761004964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761004965 dimer interface [polypeptide binding]; other site 498761004966 conserved gate region; other site 498761004967 putative PBP binding loops; other site 498761004968 ABC-ATPase subunit interface; other site 498761004969 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 498761004970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761004971 dimer interface [polypeptide binding]; other site 498761004972 conserved gate region; other site 498761004973 putative PBP binding loops; other site 498761004974 ABC-ATPase subunit interface; other site 498761004975 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 498761004976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498761004977 Walker A/P-loop; other site 498761004978 ATP binding site [chemical binding]; other site 498761004979 Q-loop/lid; other site 498761004980 ABC transporter signature motif; other site 498761004981 Walker B; other site 498761004982 D-loop; other site 498761004983 H-loop/switch region; other site 498761004984 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 498761004985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498761004986 Walker A/P-loop; other site 498761004987 ATP binding site [chemical binding]; other site 498761004988 Q-loop/lid; other site 498761004989 ABC transporter signature motif; other site 498761004990 Walker B; other site 498761004991 D-loop; other site 498761004992 H-loop/switch region; other site 498761004993 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 498761004994 diaminopimelate decarboxylase; Region: lysA; TIGR01048 498761004995 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 498761004996 active site 498761004997 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498761004998 substrate binding site [chemical binding]; other site 498761004999 catalytic residues [active] 498761005000 dimer interface [polypeptide binding]; other site 498761005001 DHH family; Region: DHH; pfam01368 498761005002 FOG: CBS domain [General function prediction only]; Region: COG0517 498761005003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 498761005004 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 498761005005 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 498761005006 active site 498761005007 NTP binding site [chemical binding]; other site 498761005008 metal binding triad [ion binding]; metal-binding site 498761005009 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 498761005010 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 498761005011 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 498761005012 Peptidase family M50; Region: Peptidase_M50; pfam02163 498761005013 active site 498761005014 putative substrate binding region [chemical binding]; other site 498761005015 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 498761005016 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 498761005017 active site 498761005018 HIGH motif; other site 498761005019 dimer interface [polypeptide binding]; other site 498761005020 KMSKS motif; other site 498761005021 ScpA/B protein; Region: ScpA_ScpB; cl00598 498761005022 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 498761005023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 498761005024 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 498761005025 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 498761005026 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 498761005027 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 498761005028 homodimer interface [polypeptide binding]; other site 498761005029 NADP binding site [chemical binding]; other site 498761005030 substrate binding site [chemical binding]; other site 498761005031 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 498761005032 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 498761005033 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 498761005034 Transglycosylase; Region: Transgly; pfam00912 498761005035 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 498761005036 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498761005037 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 498761005038 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 498761005039 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 498761005040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761005041 RNA binding surface [nucleotide binding]; other site 498761005042 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 498761005043 active site 498761005044 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 498761005045 flavoprotein, HI0933 family; Region: TIGR00275 498761005046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498761005047 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 498761005048 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 498761005049 hexamer interface [polypeptide binding]; other site 498761005050 RNA binding site [nucleotide binding]; other site 498761005051 Histidine-zinc binding site [chemical binding]; other site 498761005052 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 498761005053 homotrimer interaction site [polypeptide binding]; other site 498761005054 active site 498761005055 Response regulator receiver domain; Region: Response_reg; pfam00072 498761005056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005057 active site 498761005058 phosphorylation site [posttranslational modification] 498761005059 intermolecular recognition site; other site 498761005060 dimerization interface [polypeptide binding]; other site 498761005061 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761005062 putative binding surface; other site 498761005063 active site 498761005064 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761005065 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761005066 putative active site [active] 498761005067 putative NTP binding site [chemical binding]; other site 498761005068 putative nucleic acid binding site [nucleotide binding]; other site 498761005069 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761005070 B12 binding domain; Region: B12-binding_2; cl03653 498761005071 B12 binding domain; Region: B12-binding; pfam02310 498761005072 B12 binding site [chemical binding]; other site 498761005073 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498761005074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761005075 putative active site [active] 498761005076 heme pocket [chemical binding]; other site 498761005077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761005078 dimer interface [polypeptide binding]; other site 498761005079 phosphorylation site [posttranslational modification] 498761005080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761005081 ATP binding site [chemical binding]; other site 498761005082 Mg2+ binding site [ion binding]; other site 498761005083 G-X-G motif; other site 498761005084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005086 active site 498761005087 phosphorylation site [posttranslational modification] 498761005088 intermolecular recognition site; other site 498761005089 dimerization interface [polypeptide binding]; other site 498761005090 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 498761005091 active site 498761005092 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 498761005093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 498761005094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 498761005095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 498761005096 DsrE/DsrF-like family; Region: DrsE; cl00672 498761005097 C-terminal peptidase (prc); Region: prc; TIGR00225 498761005098 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 498761005099 protein binding site [polypeptide binding]; other site 498761005100 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 498761005101 Catalytic dyad [active] 498761005102 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761005103 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 498761005104 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 498761005105 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 498761005106 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 498761005107 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 498761005108 glutamine binding [chemical binding]; other site 498761005109 catalytic triad [active] 498761005110 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 498761005111 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 498761005112 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 498761005113 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 498761005114 active site 498761005115 ribulose/triose binding site [chemical binding]; other site 498761005116 phosphate binding site [ion binding]; other site 498761005117 substrate (anthranilate) binding pocket [chemical binding]; other site 498761005118 product (indole) binding pocket [chemical binding]; other site 498761005119 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 498761005120 active site 498761005121 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 498761005122 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 498761005123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761005124 catalytic residue [active] 498761005125 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 498761005126 substrate binding site [chemical binding]; other site 498761005127 active site 498761005128 catalytic residues [active] 498761005129 heterodimer interface [polypeptide binding]; other site 498761005130 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 498761005131 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 498761005132 prephenate dehydratase; Provisional; Region: PRK11898 498761005133 Prephenate dehydratase; Region: PDT; pfam00800 498761005134 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 498761005135 putative L-Phe binding site [chemical binding]; other site 498761005136 prephenate dehydrogenase; Validated; Region: PRK06545 498761005137 prephenate dehydrogenase; Validated; Region: PRK08507 498761005138 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 498761005139 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 498761005140 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 498761005141 hinge; other site 498761005142 active site 498761005143 cytidylate kinase; Provisional; Region: cmk; PRK00023 498761005144 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 498761005145 CMP-binding site; other site 498761005146 The sites determining sugar specificity; other site 498761005147 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 498761005148 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 498761005149 putative acyl-acceptor binding pocket; other site 498761005150 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 498761005151 LytB protein; Region: LYTB; cl00507 498761005152 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 498761005153 RNA binding site [nucleotide binding]; other site 498761005154 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 498761005155 RNA binding site [nucleotide binding]; other site 498761005156 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 498761005157 RNA binding site [nucleotide binding]; other site 498761005158 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 498761005159 RNA binding site [nucleotide binding]; other site 498761005160 DNA topoisomerase III; Provisional; Region: PRK07726 498761005161 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 498761005162 active site 498761005163 putative metal-binding site [ion binding]; other site 498761005164 putative interdomain interaction site [polypeptide binding]; other site 498761005165 putative nucleotide binding site [chemical binding]; other site 498761005166 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 498761005167 domain I; other site 498761005168 DNA binding groove [nucleotide binding] 498761005169 phosphate binding site [ion binding]; other site 498761005170 domain II; other site 498761005171 domain III; other site 498761005172 nucleotide binding site [chemical binding]; other site 498761005173 catalytic site [active] 498761005174 domain IV; other site 498761005175 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 498761005176 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 498761005177 hypothetical protein; Provisional; Region: PRK04435 498761005178 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 498761005179 homoserine dehydrogenase; Provisional; Region: PRK06349 498761005180 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 498761005181 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 498761005182 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 498761005183 threonine synthase; Reviewed; Region: PRK06721 498761005184 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 498761005185 homodimer interface [polypeptide binding]; other site 498761005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761005187 catalytic residue [active] 498761005188 homoserine kinase; Provisional; Region: PRK01212 498761005189 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 498761005190 aspartate kinase; Reviewed; Region: PRK06635 498761005191 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 498761005192 putative nucleotide binding site [chemical binding]; other site 498761005193 putative catalytic residues [active] 498761005194 putative Mg ion binding site [ion binding]; other site 498761005195 putative aspartate binding site [chemical binding]; other site 498761005196 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 498761005197 putative allosteric regulatory site; other site 498761005198 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 498761005199 putative allosteric regulatory residue; other site 498761005200 Coat F domain; Region: Coat_F; pfam07875 498761005201 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 498761005202 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 498761005203 inhibitor-cofactor binding pocket; inhibition site 498761005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761005205 catalytic residue [active] 498761005206 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 498761005207 putative hydrophobic ligand binding site [chemical binding]; other site 498761005208 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 498761005209 substrate binding pocket [chemical binding]; other site 498761005210 aspartate-rich region 1; other site 498761005211 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 498761005212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761005213 S-adenosylmethionine binding site [chemical binding]; other site 498761005214 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 498761005215 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 498761005216 UbiA prenyltransferase family; Region: UbiA; pfam01040 498761005217 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 498761005218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005219 FeS/SAM binding site; other site 498761005220 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 498761005221 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 498761005222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005223 FeS/SAM binding site; other site 498761005224 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 498761005225 Hemerythrin; Region: Hemerythrin; cd12107 498761005226 Fe binding site [ion binding]; other site 498761005227 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 498761005228 CheC-like family; Region: CheC; pfam04509 498761005229 CheC-like family; Region: CheC; pfam04509 498761005230 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 498761005231 4Fe-4S binding domain; Region: Fer4_5; pfam12801 498761005232 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761005233 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498761005234 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 498761005235 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 498761005236 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 498761005237 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 498761005238 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 498761005239 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 498761005240 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 498761005241 substrate binding pocket [chemical binding]; other site 498761005242 chain length determination region; other site 498761005243 substrate-Mg2+ binding site; other site 498761005244 catalytic residues [active] 498761005245 aspartate-rich region 1; other site 498761005246 active site lid residues [active] 498761005247 aspartate-rich region 2; other site 498761005248 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 498761005249 ResB-like family; Region: ResB; pfam05140 498761005250 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 498761005251 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 498761005252 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 498761005253 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 498761005254 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 498761005255 tRNA; other site 498761005256 putative tRNA binding site [nucleotide binding]; other site 498761005257 putative NADP binding site [chemical binding]; other site 498761005258 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 498761005259 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 498761005260 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 498761005261 domain interfaces; other site 498761005262 active site 498761005263 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 498761005264 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 498761005265 active site 498761005266 SAM binding site [chemical binding]; other site 498761005267 homodimer interface [polypeptide binding]; other site 498761005268 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 498761005269 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 498761005270 active site 498761005271 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 498761005272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005273 FeS/SAM binding site; other site 498761005274 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 498761005275 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 498761005276 dimer interface [polypeptide binding]; other site 498761005277 active site 498761005278 Schiff base residues; other site 498761005279 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 498761005280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005281 FeS/SAM binding site; other site 498761005282 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 498761005283 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 498761005284 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 498761005285 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 498761005286 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 498761005287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 498761005288 inhibitor-cofactor binding pocket; inhibition site 498761005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761005290 catalytic residue [active] 498761005291 EamA-like transporter family; Region: EamA; pfam00892 498761005292 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 498761005293 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498761005294 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 498761005295 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 498761005296 PYR/PP interface [polypeptide binding]; other site 498761005297 dimer interface [polypeptide binding]; other site 498761005298 TPP binding site [chemical binding]; other site 498761005299 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 498761005300 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 498761005301 TPP-binding site [chemical binding]; other site 498761005302 dimer interface [polypeptide binding]; other site 498761005303 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 498761005304 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 498761005305 putative valine binding site [chemical binding]; other site 498761005306 dimer interface [polypeptide binding]; other site 498761005307 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 498761005308 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 498761005309 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 498761005310 homotetramer interface [polypeptide binding]; other site 498761005311 FMN binding site [chemical binding]; other site 498761005312 homodimer contacts [polypeptide binding]; other site 498761005313 putative active site [active] 498761005314 putative substrate binding site [chemical binding]; other site 498761005315 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 498761005316 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498761005317 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 498761005318 Protein of unknown function (DUF512); Region: DUF512; pfam04459 498761005319 GTP-binding protein Der; Reviewed; Region: PRK00093 498761005320 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 498761005321 G1 box; other site 498761005322 GTP/Mg2+ binding site [chemical binding]; other site 498761005323 Switch I region; other site 498761005324 G2 box; other site 498761005325 Switch II region; other site 498761005326 G3 box; other site 498761005327 G4 box; other site 498761005328 G5 box; other site 498761005329 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 498761005330 G1 box; other site 498761005331 GTP/Mg2+ binding site [chemical binding]; other site 498761005332 Switch I region; other site 498761005333 G2 box; other site 498761005334 G3 box; other site 498761005335 Switch II region; other site 498761005336 G4 box; other site 498761005337 G5 box; other site 498761005338 membrane protein; Provisional; Region: PRK14395 498761005339 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 498761005340 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 498761005341 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 498761005342 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 498761005343 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 498761005344 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 498761005345 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 498761005346 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498761005347 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498761005348 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 498761005349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761005350 Zn2+ binding site [ion binding]; other site 498761005351 Mg2+ binding site [ion binding]; other site 498761005352 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 498761005353 DNA primase; Validated; Region: dnaG; PRK05667 498761005354 CHC2 zinc finger; Region: zf-CHC2; pfam01807 498761005355 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 498761005356 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 498761005357 active site 498761005358 metal binding site [ion binding]; metal-binding site 498761005359 interdomain interaction site; other site 498761005360 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 498761005361 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 498761005362 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 498761005363 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 498761005364 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 498761005365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761005366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498761005367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761005368 DNA binding residues [nucleotide binding] 498761005369 Family of unknown function (DUF633); Region: DUF633; pfam04816 498761005370 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 498761005371 Uncharacterized conserved protein [Function unknown]; Region: COG0327 498761005372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 498761005373 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 498761005374 Uncharacterized conserved protein [Function unknown]; Region: COG0327 498761005375 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 498761005376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498761005377 active site 498761005378 metal binding site [ion binding]; metal-binding site 498761005379 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 498761005380 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498761005381 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 498761005382 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 498761005383 GTP binding site; other site 498761005384 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 498761005385 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 498761005386 Walker A motif; other site 498761005387 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 498761005388 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 498761005389 Cysteine-rich domain; Region: CCG; pfam02754 498761005390 Cysteine-rich domain; Region: CCG; pfam02754 498761005391 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 498761005392 4Fe-4S binding domain; Region: Fer4; pfam00037 498761005393 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 498761005394 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 498761005395 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 498761005396 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761005397 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 498761005398 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 498761005399 FAD binding pocket [chemical binding]; other site 498761005400 FAD binding motif [chemical binding]; other site 498761005401 phosphate binding motif [ion binding]; other site 498761005402 beta-alpha-beta structure motif; other site 498761005403 NAD binding pocket [chemical binding]; other site 498761005404 Iron coordination center [ion binding]; other site 498761005405 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 498761005406 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 498761005407 AAA domain; Region: AAA_22; pfam13401 498761005408 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 498761005409 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498761005410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498761005411 ligand binding site [chemical binding]; other site 498761005412 flexible hinge region; other site 498761005413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 498761005414 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 498761005415 Response regulator receiver domain; Region: Response_reg; pfam00072 498761005416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005417 active site 498761005418 phosphorylation site [posttranslational modification] 498761005419 intermolecular recognition site; other site 498761005420 dimerization interface [polypeptide binding]; other site 498761005421 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 498761005422 CheC-like family; Region: CheC; pfam04509 498761005423 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498761005424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761005425 putative active site [active] 498761005426 heme pocket [chemical binding]; other site 498761005427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761005428 dimer interface [polypeptide binding]; other site 498761005429 phosphorylation site [posttranslational modification] 498761005430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761005431 ATP binding site [chemical binding]; other site 498761005432 Mg2+ binding site [ion binding]; other site 498761005433 G-X-G motif; other site 498761005434 Response regulator receiver domain; Region: Response_reg; pfam00072 498761005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005436 active site 498761005437 phosphorylation site [posttranslational modification] 498761005438 intermolecular recognition site; other site 498761005439 dimerization interface [polypeptide binding]; other site 498761005440 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 498761005441 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 498761005442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761005443 binding surface 498761005444 Tetratricopeptide repeat; Region: TPR_16; pfam13432 498761005445 TPR motif; other site 498761005446 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 498761005447 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 498761005448 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 498761005449 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761005450 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761005451 dimer interface [polypeptide binding]; other site 498761005452 putative CheW interface [polypeptide binding]; other site 498761005453 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761005454 putative binding surface; other site 498761005455 active site 498761005456 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 498761005457 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 498761005458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761005459 ATP binding site [chemical binding]; other site 498761005460 Mg2+ binding site [ion binding]; other site 498761005461 G-X-G motif; other site 498761005462 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 498761005463 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761005464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005465 active site 498761005466 phosphorylation site [posttranslational modification] 498761005467 intermolecular recognition site; other site 498761005468 dimerization interface [polypeptide binding]; other site 498761005469 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 498761005470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005471 active site 498761005472 phosphorylation site [posttranslational modification] 498761005473 intermolecular recognition site; other site 498761005474 dimerization interface [polypeptide binding]; other site 498761005475 CheB methylesterase; Region: CheB_methylest; pfam01339 498761005476 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 498761005477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005478 FeS/SAM binding site; other site 498761005479 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 498761005480 thiazole synthase; Reviewed; Region: thiG; PRK00208 498761005481 phosphate binding site [ion binding]; other site 498761005482 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 498761005483 thiS-thiF/thiG interaction site; other site 498761005484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761005485 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 498761005486 Walker A/P-loop; other site 498761005487 ATP binding site [chemical binding]; other site 498761005488 Q-loop/lid; other site 498761005489 ABC transporter signature motif; other site 498761005490 Walker B; other site 498761005491 D-loop; other site 498761005492 H-loop/switch region; other site 498761005493 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498761005494 ABC-2 type transporter; Region: ABC2_membrane; cl17235 498761005495 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 498761005496 homodimer interface [polypeptide binding]; other site 498761005497 substrate-cofactor binding pocket; other site 498761005498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761005499 catalytic residue [active] 498761005500 histidinol-phosphatase; Provisional; Region: PRK07328 498761005501 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 498761005502 active site 498761005503 dimer interface [polypeptide binding]; other site 498761005504 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 498761005505 SxDxEG motif; other site 498761005506 active site 498761005507 metal binding site [ion binding]; metal-binding site 498761005508 homopentamer interface [polypeptide binding]; other site 498761005509 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 498761005510 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 498761005511 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 498761005512 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 498761005513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761005514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498761005515 metal binding site 2 [ion binding]; metal-binding site 498761005516 putative DNA binding helix; other site 498761005517 metal binding site 1 [ion binding]; metal-binding site 498761005518 dimer interface [polypeptide binding]; other site 498761005519 structural Zn2+ binding site [ion binding]; other site 498761005520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 498761005521 Uncharacterized conserved protein [Function unknown]; Region: COG1543 498761005522 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 498761005523 active site 498761005524 substrate binding site [chemical binding]; other site 498761005525 catalytic site [active] 498761005526 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 498761005527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761005528 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 498761005529 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 498761005530 Peptidase family M28; Region: Peptidase_M28; pfam04389 498761005531 metal binding site [ion binding]; metal-binding site 498761005532 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 498761005533 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 498761005534 ATP binding site [chemical binding]; other site 498761005535 substrate interface [chemical binding]; other site 498761005536 Flavoprotein; Region: Flavoprotein; pfam02441 498761005537 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 498761005538 cell division protein MraZ; Reviewed; Region: PRK00326 498761005539 MraZ protein; Region: MraZ; pfam02381 498761005540 MraZ protein; Region: MraZ; pfam02381 498761005541 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 498761005542 MraW methylase family; Region: Methyltransf_5; cl17771 498761005543 Cell division protein FtsL; Region: FtsL; cl11433 498761005544 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 498761005545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498761005546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498761005547 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 498761005548 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 498761005549 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 498761005550 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498761005551 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761005552 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498761005553 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 498761005554 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498761005555 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761005556 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 498761005557 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 498761005558 Mg++ binding site [ion binding]; other site 498761005559 putative catalytic motif [active] 498761005560 putative substrate binding site [chemical binding]; other site 498761005561 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 498761005562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761005563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498761005564 cell division protein FtsW; Region: ftsW; TIGR02614 498761005565 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 498761005566 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 498761005567 homodimer interface [polypeptide binding]; other site 498761005568 active site 498761005569 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 498761005570 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498761005571 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761005572 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498761005573 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 498761005574 FAD binding domain; Region: FAD_binding_4; pfam01565 498761005575 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 498761005576 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 498761005577 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 498761005578 hinge; other site 498761005579 active site 498761005580 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 498761005581 Cell division protein FtsQ; Region: FtsQ; pfam03799 498761005582 cell division protein FtsZ; Validated; Region: PRK09330 498761005583 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 498761005584 nucleotide binding site [chemical binding]; other site 498761005585 SulA interaction site; other site 498761005586 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 498761005587 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 498761005588 sporulation sigma factor SigE; Reviewed; Region: PRK08301 498761005589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761005590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761005591 DNA binding residues [nucleotide binding] 498761005592 sporulation sigma factor SigG; Reviewed; Region: PRK08215 498761005593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761005594 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498761005595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761005596 DNA binding residues [nucleotide binding] 498761005597 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 498761005598 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 498761005599 ATP cone domain; Region: ATP-cone; pfam03477 498761005600 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 498761005601 ATP cone domain; Region: ATP-cone; pfam03477 498761005602 Class III ribonucleotide reductase; Region: RNR_III; cd01675 498761005603 effector binding site; other site 498761005604 active site 498761005605 Zn binding site [ion binding]; other site 498761005606 glycine loop; other site 498761005607 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 498761005608 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 498761005609 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 498761005610 catalytic core [active] 498761005611 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 498761005612 ThiC family; Region: ThiC; cl08031 498761005613 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 498761005614 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 498761005615 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 498761005616 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 498761005617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005618 FeS/SAM binding site; other site 498761005619 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 498761005620 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 498761005621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761005622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761005623 active site 498761005624 phosphorylation site [posttranslational modification] 498761005625 intermolecular recognition site; other site 498761005626 dimerization interface [polypeptide binding]; other site 498761005627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761005628 DNA binding site [nucleotide binding] 498761005629 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498761005630 PAS domain; Region: PAS; smart00091 498761005631 putative active site [active] 498761005632 heme pocket [chemical binding]; other site 498761005633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761005634 dimer interface [polypeptide binding]; other site 498761005635 phosphorylation site [posttranslational modification] 498761005636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761005637 ATP binding site [chemical binding]; other site 498761005638 Mg2+ binding site [ion binding]; other site 498761005639 G-X-G motif; other site 498761005640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761005641 metal binding site [ion binding]; metal-binding site 498761005642 active site 498761005643 I-site; other site 498761005644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498761005645 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 498761005646 FOG: CBS domain [General function prediction only]; Region: COG0517 498761005647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761005648 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761005649 metal binding site [ion binding]; metal-binding site 498761005650 active site 498761005651 I-site; other site 498761005652 PBP superfamily domain; Region: PBP_like_2; cl17296 498761005653 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 498761005654 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 498761005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761005656 dimer interface [polypeptide binding]; other site 498761005657 conserved gate region; other site 498761005658 putative PBP binding loops; other site 498761005659 ABC-ATPase subunit interface; other site 498761005660 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 498761005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761005662 dimer interface [polypeptide binding]; other site 498761005663 conserved gate region; other site 498761005664 putative PBP binding loops; other site 498761005665 ABC-ATPase subunit interface; other site 498761005666 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 498761005667 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 498761005668 Walker A/P-loop; other site 498761005669 ATP binding site [chemical binding]; other site 498761005670 Q-loop/lid; other site 498761005671 ABC transporter signature motif; other site 498761005672 Walker B; other site 498761005673 D-loop; other site 498761005674 H-loop/switch region; other site 498761005675 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 498761005676 PhoU domain; Region: PhoU; pfam01895 498761005677 PhoU domain; Region: PhoU; pfam01895 498761005678 uracil transporter; Provisional; Region: PRK10720 498761005679 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 498761005680 lipoyl-biotinyl attachment site [posttranslational modification]; other site 498761005681 HlyD family secretion protein; Region: HlyD_2; pfam12700 498761005682 putative membrane fusion protein; Region: TIGR02828 498761005683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 498761005684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498761005685 catalytic residue [active] 498761005686 Protein of unknown function (DUF552); Region: DUF552; pfam04472 498761005687 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 498761005688 pyrroline-5-carboxylate reductase; Region: PLN02688 498761005689 YGGT family; Region: YGGT; pfam02325 498761005690 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 498761005691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 498761005692 RNA binding surface [nucleotide binding]; other site 498761005693 DivIVA protein; Region: DivIVA; pfam05103 498761005694 DivIVA domain; Region: DivI1A_domain; TIGR03544 498761005695 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 498761005696 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 498761005697 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 498761005698 HIGH motif; other site 498761005699 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 498761005700 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 498761005701 active site 498761005702 KMSKS motif; other site 498761005703 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 498761005704 tRNA binding surface [nucleotide binding]; other site 498761005705 anticodon binding site; other site 498761005706 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 498761005707 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 498761005708 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761005709 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761005710 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 498761005711 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 498761005712 Transport protein particle (TRAPP) component; Region: TRAPP; cl02135 498761005713 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 498761005714 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498761005715 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 498761005716 lipoprotein signal peptidase; Provisional; Region: PRK14787 498761005717 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 498761005718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498761005719 RNA binding surface [nucleotide binding]; other site 498761005720 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 498761005721 active site 498761005722 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 498761005723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761005724 active site 498761005725 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 498761005726 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498761005727 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498761005728 dihydroorotase; Validated; Region: pyrC; PRK09357 498761005729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498761005730 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 498761005731 active site 498761005732 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 498761005733 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 498761005734 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 498761005735 catalytic site [active] 498761005736 subunit interface [polypeptide binding]; other site 498761005737 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 498761005738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498761005739 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498761005740 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 498761005741 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498761005742 ATP-grasp domain; Region: ATP-grasp_4; cl17255 498761005743 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 498761005744 IMP binding site; other site 498761005745 dimer interface [polypeptide binding]; other site 498761005746 interdomain contacts; other site 498761005747 partial ornithine binding site; other site 498761005748 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 498761005749 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 498761005750 FAD binding pocket [chemical binding]; other site 498761005751 FAD binding motif [chemical binding]; other site 498761005752 phosphate binding motif [ion binding]; other site 498761005753 beta-alpha-beta structure motif; other site 498761005754 NAD binding pocket [chemical binding]; other site 498761005755 Iron coordination center [ion binding]; other site 498761005756 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 498761005757 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 498761005758 heterodimer interface [polypeptide binding]; other site 498761005759 active site 498761005760 FMN binding site [chemical binding]; other site 498761005761 homodimer interface [polypeptide binding]; other site 498761005762 substrate binding site [chemical binding]; other site 498761005763 Uncharacterized conserved protein [Function unknown]; Region: COG3379 498761005764 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 498761005765 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498761005766 NlpC/P60 family; Region: NLPC_P60; pfam00877 498761005767 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761005768 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 498761005769 anti sigma factor interaction site; other site 498761005770 regulatory phosphorylation site [posttranslational modification]; other site 498761005771 Cache domain; Region: Cache_1; pfam02743 498761005772 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498761005773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761005774 dimerization interface [polypeptide binding]; other site 498761005775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761005776 dimer interface [polypeptide binding]; other site 498761005777 putative CheW interface [polypeptide binding]; other site 498761005778 Cache domain; Region: Cache_1; pfam02743 498761005779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761005780 dimerization interface [polypeptide binding]; other site 498761005781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761005782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761005783 dimer interface [polypeptide binding]; other site 498761005784 putative CheW interface [polypeptide binding]; other site 498761005785 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 498761005786 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 498761005787 Domain of unknown function (DUF814); Region: DUF814; pfam05670 498761005788 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 498761005789 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498761005790 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498761005791 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498761005792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761005793 motif II; other site 498761005794 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498761005795 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 498761005796 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 498761005797 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 498761005798 hypothetical protein; Provisional; Region: PRK11820 498761005799 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 498761005800 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 498761005801 hypothetical protein; Provisional; Region: PRK04323 498761005802 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 498761005803 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 498761005804 catalytic site [active] 498761005805 G-X2-G-X-G-K; other site 498761005806 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 498761005807 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 498761005808 Flavoprotein; Region: Flavoprotein; pfam02441 498761005809 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 498761005810 S-adenosylmethionine synthetase; Validated; Region: PRK05250 498761005811 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 498761005812 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 498761005813 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 498761005814 primosome assembly protein PriA; Validated; Region: PRK05580 498761005815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761005816 ATP binding site [chemical binding]; other site 498761005817 putative Mg++ binding site [ion binding]; other site 498761005818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761005819 nucleotide binding region [chemical binding]; other site 498761005820 ATP-binding site [chemical binding]; other site 498761005821 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 498761005822 active site 498761005823 catalytic residues [active] 498761005824 metal binding site [ion binding]; metal-binding site 498761005825 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 498761005826 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 498761005827 putative active site [active] 498761005828 substrate binding site [chemical binding]; other site 498761005829 putative cosubstrate binding site; other site 498761005830 catalytic site [active] 498761005831 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 498761005832 substrate binding site [chemical binding]; other site 498761005833 Protein of unknown function DUF116; Region: DUF116; pfam01976 498761005834 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 498761005835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005836 FeS/SAM binding site; other site 498761005837 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 498761005838 active site 498761005839 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 498761005840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 498761005841 active site 498761005842 ATP binding site [chemical binding]; other site 498761005843 substrate binding site [chemical binding]; other site 498761005844 activation loop (A-loop); other site 498761005845 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498761005846 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498761005847 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498761005848 GTPase RsgA; Reviewed; Region: PRK00098 498761005849 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 498761005850 RNA binding site [nucleotide binding]; other site 498761005851 homodimer interface [polypeptide binding]; other site 498761005852 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 498761005853 GTPase/Zn-binding domain interface [polypeptide binding]; other site 498761005854 GTP/Mg2+ binding site [chemical binding]; other site 498761005855 G4 box; other site 498761005856 G5 box; other site 498761005857 G1 box; other site 498761005858 Switch I region; other site 498761005859 G2 box; other site 498761005860 G3 box; other site 498761005861 Switch II region; other site 498761005862 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 498761005863 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 498761005864 substrate binding site [chemical binding]; other site 498761005865 hexamer interface [polypeptide binding]; other site 498761005866 metal binding site [ion binding]; metal-binding site 498761005867 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 498761005868 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 498761005869 catalytic motif [active] 498761005870 Zn binding site [ion binding]; other site 498761005871 RibD C-terminal domain; Region: RibD_C; cl17279 498761005872 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 498761005873 Lumazine binding domain; Region: Lum_binding; pfam00677 498761005874 Lumazine binding domain; Region: Lum_binding; pfam00677 498761005875 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 498761005876 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 498761005877 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 498761005878 dimerization interface [polypeptide binding]; other site 498761005879 active site 498761005880 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 498761005881 homopentamer interface [polypeptide binding]; other site 498761005882 active site 498761005883 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 498761005884 substrate binding site [chemical binding]; other site 498761005885 ATP binding site [chemical binding]; other site 498761005886 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 498761005887 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 498761005888 dimerization interface [polypeptide binding]; other site 498761005889 domain crossover interface; other site 498761005890 redox-dependent activation switch; other site 498761005891 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 498761005892 Asp23 family; Region: Asp23; pfam03780 498761005893 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 498761005894 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 498761005895 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 498761005896 generic binding surface II; other site 498761005897 ssDNA binding site; other site 498761005898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761005899 putative Mg++ binding site [ion binding]; other site 498761005900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761005901 nucleotide binding region [chemical binding]; other site 498761005902 ATP-binding site [chemical binding]; other site 498761005903 germination protease; Provisional; Region: PRK12362 498761005904 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 498761005905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761005906 S-adenosylmethionine binding site [chemical binding]; other site 498761005907 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 498761005908 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 498761005909 active site 498761005910 (T/H)XGH motif; other site 498761005911 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 498761005912 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 498761005913 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 498761005914 propionate/acetate kinase; Provisional; Region: PRK12379 498761005915 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 498761005916 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 498761005917 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 498761005918 putative phosphate acyltransferase; Provisional; Region: PRK05331 498761005919 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 498761005920 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 498761005921 dimer interface [polypeptide binding]; other site 498761005922 active site 498761005923 CoA binding pocket [chemical binding]; other site 498761005924 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 498761005925 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 498761005926 FMN binding site [chemical binding]; other site 498761005927 substrate binding site [chemical binding]; other site 498761005928 putative catalytic residue [active] 498761005929 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 498761005930 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 498761005931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 498761005932 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 498761005933 NAD(P) binding site [chemical binding]; other site 498761005934 homotetramer interface [polypeptide binding]; other site 498761005935 homodimer interface [polypeptide binding]; other site 498761005936 active site 498761005937 acyl carrier protein; Provisional; Region: acpP; PRK00982 498761005938 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 498761005939 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 498761005940 FMN binding site [chemical binding]; other site 498761005941 substrate binding site [chemical binding]; other site 498761005942 putative catalytic residue [active] 498761005943 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 498761005944 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 498761005945 dimer interface [polypeptide binding]; other site 498761005946 active site 498761005947 ribonuclease III; Reviewed; Region: rnc; PRK00102 498761005948 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 498761005949 dimerization interface [polypeptide binding]; other site 498761005950 active site 498761005951 metal binding site [ion binding]; metal-binding site 498761005952 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 498761005953 dsRNA binding site [nucleotide binding]; other site 498761005954 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498761005955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761005956 FeS/SAM binding site; other site 498761005957 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 498761005958 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 498761005959 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 498761005960 Walker A/P-loop; other site 498761005961 ATP binding site [chemical binding]; other site 498761005962 Q-loop/lid; other site 498761005963 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 498761005964 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 498761005965 ABC transporter signature motif; other site 498761005966 Walker B; other site 498761005967 D-loop; other site 498761005968 H-loop/switch region; other site 498761005969 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 498761005970 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 498761005971 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 498761005972 P loop; other site 498761005973 GTP binding site [chemical binding]; other site 498761005974 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 498761005975 active site 1 [active] 498761005976 dimer interface [polypeptide binding]; other site 498761005977 hexamer interface [polypeptide binding]; other site 498761005978 active site 2 [active] 498761005979 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 498761005980 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 498761005981 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 498761005982 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 498761005983 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 498761005984 active site 498761005985 putative substrate binding pocket [chemical binding]; other site 498761005986 GAF domain; Region: GAF; pfam01590 498761005987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761005988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761005989 metal binding site [ion binding]; metal-binding site 498761005990 active site 498761005991 I-site; other site 498761005992 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 498761005993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761005994 DNA binding residues [nucleotide binding] 498761005995 signal recognition particle protein; Provisional; Region: PRK10867 498761005996 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 498761005997 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 498761005998 P loop; other site 498761005999 GTP binding site [chemical binding]; other site 498761006000 Signal peptide binding domain; Region: SRP_SPB; pfam02978 498761006001 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 498761006002 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 498761006003 hypothetical protein; Provisional; Region: PRK00468 498761006004 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 498761006005 RimM N-terminal domain; Region: RimM; pfam01782 498761006006 PRC-barrel domain; Region: PRC; pfam05239 498761006007 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 498761006008 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 498761006009 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 498761006010 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 498761006011 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 498761006012 Catalytic site [active] 498761006013 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 498761006014 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 498761006015 GTP/Mg2+ binding site [chemical binding]; other site 498761006016 G4 box; other site 498761006017 G5 box; other site 498761006018 G1 box; other site 498761006019 Switch I region; other site 498761006020 G2 box; other site 498761006021 G3 box; other site 498761006022 Switch II region; other site 498761006023 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 498761006024 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 498761006025 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 498761006026 RNA/DNA hybrid binding site [nucleotide binding]; other site 498761006027 active site 498761006028 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 498761006029 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 498761006030 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 498761006031 NADH dehydrogenase subunit B; Validated; Region: PRK06411 498761006032 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 498761006033 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 498761006034 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 498761006035 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 498761006036 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 498761006037 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 498761006038 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 498761006039 4Fe-4S binding domain; Region: Fer4; cl02805 498761006040 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 498761006041 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 498761006042 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 498761006043 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 498761006044 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 498761006045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 498761006046 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 498761006047 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 498761006048 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 498761006049 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 498761006050 hypothetical protein; Reviewed; Region: PRK12497 498761006051 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 498761006052 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 498761006053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006054 Walker A motif; other site 498761006055 ATP binding site [chemical binding]; other site 498761006056 Walker B motif; other site 498761006057 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 498761006058 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 498761006059 DNA protecting protein DprA; Region: dprA; TIGR00732 498761006060 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 498761006061 DNA topoisomerase I; Validated; Region: PRK05582 498761006062 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 498761006063 active site 498761006064 interdomain interaction site; other site 498761006065 putative metal-binding site [ion binding]; other site 498761006066 nucleotide binding site [chemical binding]; other site 498761006067 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 498761006068 domain I; other site 498761006069 DNA binding groove [nucleotide binding] 498761006070 phosphate binding site [ion binding]; other site 498761006071 domain II; other site 498761006072 domain III; other site 498761006073 nucleotide binding site [chemical binding]; other site 498761006074 catalytic site [active] 498761006075 domain IV; other site 498761006076 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 498761006077 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 498761006078 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 498761006079 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 498761006080 Glucose inhibited division protein A; Region: GIDA; pfam01134 498761006081 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 498761006082 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 498761006083 active site 498761006084 Int/Topo IB signature motif; other site 498761006085 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 498761006086 active site 498761006087 HslU subunit interaction site [polypeptide binding]; other site 498761006088 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 498761006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006090 Walker A motif; other site 498761006091 ATP binding site [chemical binding]; other site 498761006092 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 498761006093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 498761006094 transcriptional repressor CodY; Validated; Region: PRK04158 498761006095 CodY GAF-like domain; Region: CodY; pfam06018 498761006096 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 498761006097 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 498761006098 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 498761006099 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 498761006100 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498761006101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498761006102 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 498761006103 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 498761006104 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 498761006105 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 498761006106 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 498761006107 FliG C-terminal domain; Region: FliG_C; pfam01706 498761006108 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 498761006109 Flagellar assembly protein FliH; Region: FliH; pfam02108 498761006110 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 498761006111 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498761006112 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 498761006113 Walker A motif/ATP binding site; other site 498761006114 Walker B motif; other site 498761006115 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 498761006116 Uncharacterized conserved protein [Function unknown]; Region: COG3334 498761006117 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 498761006118 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 498761006119 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 498761006120 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 498761006121 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 498761006122 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498761006123 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 498761006124 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498761006125 Flagellar protein (FlbD); Region: FlbD; pfam06289 498761006126 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 498761006127 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 498761006128 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 498761006129 flagellar motor switch protein; Validated; Region: PRK08119 498761006130 Transposase domain (DUF772); Region: DUF772; pfam05598 498761006131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761006132 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761006133 flagellar motor switch protein FliN; Region: fliN; TIGR02480 498761006134 Response regulator receiver domain; Region: Response_reg; pfam00072 498761006135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761006136 active site 498761006137 phosphorylation site [posttranslational modification] 498761006138 intermolecular recognition site; other site 498761006139 dimerization interface [polypeptide binding]; other site 498761006140 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 498761006141 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 498761006142 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 498761006143 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 498761006144 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 498761006145 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 498761006146 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 498761006147 FHIPEP family; Region: FHIPEP; pfam00771 498761006148 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 498761006149 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761006150 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 498761006151 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 498761006152 P-loop; other site 498761006153 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 498761006154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761006155 active site 498761006156 phosphorylation site [posttranslational modification] 498761006157 intermolecular recognition site; other site 498761006158 dimerization interface [polypeptide binding]; other site 498761006159 CheB methylesterase; Region: CheB_methylest; pfam01339 498761006160 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 498761006161 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761006162 putative binding surface; other site 498761006163 active site 498761006164 P2 response regulator binding domain; Region: P2; pfam07194 498761006165 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 498761006166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761006167 ATP binding site [chemical binding]; other site 498761006168 Mg2+ binding site [ion binding]; other site 498761006169 G-X-G motif; other site 498761006170 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 498761006171 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 498761006172 putative CheA interaction surface; other site 498761006173 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 498761006174 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 498761006175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761006176 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498761006177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761006178 DNA binding residues [nucleotide binding] 498761006179 Protein of unknown function (DUF342); Region: DUF342; pfam03961 498761006180 YceG-like family; Region: YceG; pfam02618 498761006181 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 498761006182 rRNA interaction site [nucleotide binding]; other site 498761006183 S8 interaction site; other site 498761006184 putative laminin-1 binding site; other site 498761006185 elongation factor Ts; Reviewed; Region: tsf; PRK12332 498761006186 UBA/TS-N domain; Region: UBA; pfam00627 498761006187 Elongation factor TS; Region: EF_TS; pfam00889 498761006188 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 498761006189 putative nucleotide binding site [chemical binding]; other site 498761006190 uridine monophosphate binding site [chemical binding]; other site 498761006191 homohexameric interface [polypeptide binding]; other site 498761006192 ribosome recycling factor; Reviewed; Region: frr; PRK00083 498761006193 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 498761006194 hinge region; other site 498761006195 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 498761006196 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 498761006197 catalytic residue [active] 498761006198 putative FPP diphosphate binding site; other site 498761006199 putative FPP binding hydrophobic cleft; other site 498761006200 dimer interface [polypeptide binding]; other site 498761006201 putative IPP diphosphate binding site; other site 498761006202 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 498761006203 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 498761006204 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 498761006205 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 498761006206 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 498761006207 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 498761006208 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 498761006209 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 498761006210 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 498761006211 active site 498761006212 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 498761006213 protein binding site [polypeptide binding]; other site 498761006214 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 498761006215 putative substrate binding region [chemical binding]; other site 498761006216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 498761006217 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 498761006218 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 498761006219 prolyl-tRNA synthetase; Provisional; Region: PRK09194 498761006220 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 498761006221 dimer interface [polypeptide binding]; other site 498761006222 motif 1; other site 498761006223 active site 498761006224 motif 2; other site 498761006225 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 498761006226 putative deacylase active site [active] 498761006227 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498761006228 active site 498761006229 motif 3; other site 498761006230 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 498761006231 anticodon binding site; other site 498761006232 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 498761006233 Ligand binding site; other site 498761006234 Putative Catalytic site; other site 498761006235 DXD motif; other site 498761006236 Transposase domain (DUF772); Region: DUF772; pfam05598 498761006237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761006238 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761006239 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 498761006240 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 498761006241 putative active site [active] 498761006242 PhoH-like protein; Region: PhoH; pfam02562 498761006243 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 498761006244 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761006245 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 498761006246 generic binding surface II; other site 498761006247 generic binding surface I; other site 498761006248 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 498761006249 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 498761006250 active site 498761006251 putative PHP Thumb interface [polypeptide binding]; other site 498761006252 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 498761006253 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 498761006254 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 498761006255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761006256 Walker A/P-loop; other site 498761006257 ATP binding site [chemical binding]; other site 498761006258 Q-loop/lid; other site 498761006259 ABC transporter signature motif; other site 498761006260 Walker B; other site 498761006261 D-loop; other site 498761006262 H-loop/switch region; other site 498761006263 TOBE domain; Region: TOBE_2; pfam08402 498761006264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761006265 dimer interface [polypeptide binding]; other site 498761006266 conserved gate region; other site 498761006267 putative PBP binding loops; other site 498761006268 ABC-ATPase subunit interface; other site 498761006269 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 498761006270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498761006271 dimer interface [polypeptide binding]; other site 498761006272 conserved gate region; other site 498761006273 putative PBP binding loops; other site 498761006274 ABC-ATPase subunit interface; other site 498761006275 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 498761006276 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 498761006277 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 498761006278 Integral membrane protein DUF92; Region: DUF92; pfam01940 498761006279 Cupin domain; Region: Cupin_2; pfam07883 498761006280 ribosome maturation protein RimP; Reviewed; Region: PRK00092 498761006281 Sm and related proteins; Region: Sm_like; cl00259 498761006282 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 498761006283 putative oligomer interface [polypeptide binding]; other site 498761006284 putative RNA binding site [nucleotide binding]; other site 498761006285 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 498761006286 NusA N-terminal domain; Region: NusA_N; pfam08529 498761006287 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 498761006288 RNA binding site [nucleotide binding]; other site 498761006289 homodimer interface [polypeptide binding]; other site 498761006290 NusA-like KH domain; Region: KH_5; pfam13184 498761006291 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 498761006292 G-X-X-G motif; other site 498761006293 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 498761006294 putative RNA binding cleft [nucleotide binding]; other site 498761006295 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 498761006296 translation initiation factor IF-2; Region: IF-2; TIGR00487 498761006297 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 498761006298 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 498761006299 G1 box; other site 498761006300 putative GEF interaction site [polypeptide binding]; other site 498761006301 GTP/Mg2+ binding site [chemical binding]; other site 498761006302 Switch I region; other site 498761006303 G2 box; other site 498761006304 G3 box; other site 498761006305 Switch II region; other site 498761006306 G4 box; other site 498761006307 G5 box; other site 498761006308 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 498761006309 Translation-initiation factor 2; Region: IF-2; pfam11987 498761006310 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 498761006311 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 498761006312 DHH family; Region: DHH; pfam01368 498761006313 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 498761006314 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 498761006315 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 498761006316 RNA binding site [nucleotide binding]; other site 498761006317 active site 498761006318 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 498761006319 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 498761006320 active site 498761006321 Riboflavin kinase; Region: Flavokinase; pfam01687 498761006322 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 498761006323 16S/18S rRNA binding site [nucleotide binding]; other site 498761006324 S13e-L30e interaction site [polypeptide binding]; other site 498761006325 25S rRNA binding site [nucleotide binding]; other site 498761006326 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 498761006327 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 498761006328 RNase E interface [polypeptide binding]; other site 498761006329 trimer interface [polypeptide binding]; other site 498761006330 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 498761006331 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 498761006332 RNase E interface [polypeptide binding]; other site 498761006333 trimer interface [polypeptide binding]; other site 498761006334 active site 498761006335 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 498761006336 putative nucleic acid binding region [nucleotide binding]; other site 498761006337 G-X-X-G motif; other site 498761006338 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 498761006339 RNA binding site [nucleotide binding]; other site 498761006340 domain interface; other site 498761006341 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 498761006342 NodB motif; other site 498761006343 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498761006344 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 498761006345 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 498761006346 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 498761006347 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 498761006348 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 498761006349 dihydrodipicolinate reductase; Provisional; Region: PRK00048 498761006350 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 498761006351 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 498761006352 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 498761006353 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 498761006354 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 498761006355 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 498761006356 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 498761006357 aspartate kinase I; Reviewed; Region: PRK08210 498761006358 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 498761006359 nucleotide binding site [chemical binding]; other site 498761006360 substrate binding site [chemical binding]; other site 498761006361 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 498761006362 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 498761006363 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 498761006364 dihydrodipicolinate synthase; Region: dapA; TIGR00674 498761006365 dimer interface [polypeptide binding]; other site 498761006366 active site 498761006367 catalytic residue [active] 498761006368 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 498761006369 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761006370 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498761006371 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 498761006372 Clp protease; Region: CLP_protease; pfam00574 498761006373 active site 498761006374 YlzJ-like protein; Region: YlzJ; pfam14035 498761006375 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 498761006376 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 498761006377 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 498761006378 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 498761006379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498761006380 active site 498761006381 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 498761006382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 498761006383 active site residue [active] 498761006384 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 498761006385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761006386 non-specific DNA binding site [nucleotide binding]; other site 498761006387 salt bridge; other site 498761006388 sequence-specific DNA binding site [nucleotide binding]; other site 498761006389 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 498761006390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 498761006391 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 498761006392 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 498761006393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761006394 FeS/SAM binding site; other site 498761006395 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 498761006396 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 498761006397 putative active site; other site 498761006398 catalytic triad [active] 498761006399 putative dimer interface [polypeptide binding]; other site 498761006400 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 498761006401 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 498761006402 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 498761006403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498761006404 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 498761006405 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 498761006406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 498761006407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 498761006408 Domain of unknown function (DUF4324); Region: DUF4324; pfam14212 498761006409 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 498761006410 nucleotide binding site [chemical binding]; other site 498761006411 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 498761006412 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 498761006413 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 498761006414 putative DNA binding site [nucleotide binding]; other site 498761006415 putative homodimer interface [polypeptide binding]; other site 498761006416 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 498761006417 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 498761006418 active site 498761006419 Substrate binding site; other site 498761006420 Mg++ binding site; other site 498761006421 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 498761006422 BioY family; Region: BioY; pfam02632 498761006423 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 498761006424 AAA domain; Region: AAA_30; pfam13604 498761006425 Family description; Region: UvrD_C_2; pfam13538 498761006426 Transcriptional regulators [Transcription]; Region: FadR; COG2186 498761006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498761006428 DNA-binding site [nucleotide binding]; DNA binding site 498761006429 FCD domain; Region: FCD; pfam07729 498761006430 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 498761006431 PcrB family; Region: PcrB; pfam01884 498761006432 phosphate binding site [ion binding]; other site 498761006433 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498761006434 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498761006435 NodB motif; other site 498761006436 active site 498761006437 catalytic site [active] 498761006438 Zn binding site [ion binding]; other site 498761006439 Response regulator receiver domain; Region: Response_reg; pfam00072 498761006440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761006441 active site 498761006442 phosphorylation site [posttranslational modification] 498761006443 intermolecular recognition site; other site 498761006444 dimerization interface [polypeptide binding]; other site 498761006445 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 498761006446 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 498761006447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498761006448 Coenzyme A binding pocket [chemical binding]; other site 498761006449 FOG: CBS domain [General function prediction only]; Region: COG0517 498761006450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 498761006451 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 498761006452 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 498761006453 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 498761006454 active site 498761006455 Zn binding site [ion binding]; other site 498761006456 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 498761006457 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 498761006458 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 498761006459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761006460 FeS/SAM binding site; other site 498761006461 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 498761006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006463 Walker A motif; other site 498761006464 ATP binding site [chemical binding]; other site 498761006465 Walker B motif; other site 498761006466 arginine finger; other site 498761006467 Peptidase family M41; Region: Peptidase_M41; pfam01434 498761006468 competence damage-inducible protein A; Provisional; Region: PRK00549 498761006469 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 498761006470 putative MPT binding site; other site 498761006471 Competence-damaged protein; Region: CinA; pfam02464 498761006472 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 498761006473 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 498761006474 ATP binding site [chemical binding]; other site 498761006475 Mg++ binding site [ion binding]; other site 498761006476 motif III; other site 498761006477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761006478 nucleotide binding region [chemical binding]; other site 498761006479 ATP-binding site [chemical binding]; other site 498761006480 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 498761006481 RNA binding site [nucleotide binding]; other site 498761006482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 498761006483 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 498761006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 498761006485 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 498761006486 recombinase A; Provisional; Region: recA; PRK09354 498761006487 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 498761006488 hexamer interface [polypeptide binding]; other site 498761006489 Walker A motif; other site 498761006490 ATP binding site [chemical binding]; other site 498761006491 Walker B motif; other site 498761006492 RecX family; Region: RecX; pfam02631 498761006493 phosphodiesterase; Provisional; Region: PRK12704 498761006494 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761006495 Zn2+ binding site [ion binding]; other site 498761006496 Mg2+ binding site [ion binding]; other site 498761006497 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 498761006498 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498761006499 putative active site [active] 498761006500 metal binding site [ion binding]; metal-binding site 498761006501 homodimer binding site [polypeptide binding]; other site 498761006502 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 498761006503 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 498761006504 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 498761006505 active site 498761006506 dimer interface [polypeptide binding]; other site 498761006507 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 498761006508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761006509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761006510 homodimer interface [polypeptide binding]; other site 498761006511 catalytic residue [active] 498761006512 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 498761006513 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 498761006514 active site 498761006515 putative homodimer interface [polypeptide binding]; other site 498761006516 SAM binding site [chemical binding]; other site 498761006517 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 498761006518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761006519 S-adenosylmethionine binding site [chemical binding]; other site 498761006520 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 498761006521 active site 498761006522 SAM binding site [chemical binding]; other site 498761006523 homodimer interface [polypeptide binding]; other site 498761006524 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 498761006525 active site 498761006526 SAM binding site [chemical binding]; other site 498761006527 homodimer interface [polypeptide binding]; other site 498761006528 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 498761006529 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 498761006530 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 498761006531 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 498761006532 active site 498761006533 SAM binding site [chemical binding]; other site 498761006534 homodimer interface [polypeptide binding]; other site 498761006535 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 498761006536 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 498761006537 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 498761006538 putative active site [active] 498761006539 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 498761006540 Precorrin-8X methylmutase; Region: CbiC; pfam02570 498761006541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761006542 Zn2+ binding site [ion binding]; other site 498761006543 Mg2+ binding site [ion binding]; other site 498761006544 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 498761006545 homotrimer interface [polypeptide binding]; other site 498761006546 Walker A motif; other site 498761006547 GTP binding site [chemical binding]; other site 498761006548 Walker B motif; other site 498761006549 cobyric acid synthase; Provisional; Region: PRK00784 498761006550 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 498761006551 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 498761006552 catalytic triad [active] 498761006553 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 498761006554 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 498761006555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498761006556 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 498761006557 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 498761006558 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 498761006559 Walker A motif; other site 498761006560 homodimer interface [polypeptide binding]; other site 498761006561 ATP binding site [chemical binding]; other site 498761006562 hydroxycobalamin binding site [chemical binding]; other site 498761006563 Walker B motif; other site 498761006564 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 498761006565 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 498761006566 putative dimer interface [polypeptide binding]; other site 498761006567 active site pocket [active] 498761006568 putative cataytic base [active] 498761006569 cobalamin synthase; Reviewed; Region: cobS; PRK00235 498761006570 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 498761006571 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 498761006572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761006573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761006574 homodimer interface [polypeptide binding]; other site 498761006575 catalytic residue [active] 498761006576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 498761006577 catalytic core [active] 498761006578 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 498761006579 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 498761006580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 498761006581 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 498761006582 active site 498761006583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761006584 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 498761006585 active site 498761006586 motif I; other site 498761006587 motif II; other site 498761006588 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 498761006589 plasmid segregation protein ParM; Provisional; Region: PRK13917 498761006590 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 498761006591 Mg binding site [ion binding]; other site 498761006592 nucleotide binding site [chemical binding]; other site 498761006593 putative protofilament interface [polypeptide binding]; other site 498761006594 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 498761006595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761006596 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498761006597 recombination factor protein RarA; Reviewed; Region: PRK13342 498761006598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006599 Walker A motif; other site 498761006600 ATP binding site [chemical binding]; other site 498761006601 Walker B motif; other site 498761006602 arginine finger; other site 498761006603 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 498761006604 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 498761006605 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 498761006606 G1 box; other site 498761006607 putative GEF interaction site [polypeptide binding]; other site 498761006608 GTP/Mg2+ binding site [chemical binding]; other site 498761006609 Switch I region; other site 498761006610 G2 box; other site 498761006611 G3 box; other site 498761006612 Switch II region; other site 498761006613 G4 box; other site 498761006614 G5 box; other site 498761006615 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 498761006616 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 498761006617 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 498761006618 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 498761006619 substrate binding site [chemical binding]; other site 498761006620 dimer interface [polypeptide binding]; other site 498761006621 ATP binding site [chemical binding]; other site 498761006622 D-ribose pyranase; Provisional; Region: PRK11797 498761006623 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 498761006624 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 498761006625 Walker A/P-loop; other site 498761006626 ATP binding site [chemical binding]; other site 498761006627 Q-loop/lid; other site 498761006628 ABC transporter signature motif; other site 498761006629 Walker B; other site 498761006630 D-loop; other site 498761006631 H-loop/switch region; other site 498761006632 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 498761006633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761006634 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 498761006635 TM-ABC transporter signature motif; other site 498761006636 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 498761006637 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 498761006638 ligand binding site [chemical binding]; other site 498761006639 dimerization interface [polypeptide binding]; other site 498761006640 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 498761006641 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 498761006642 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 498761006643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498761006644 ABC-ATPase subunit interface; other site 498761006645 dimer interface [polypeptide binding]; other site 498761006646 putative PBP binding regions; other site 498761006647 ferric uptake regulator; Provisional; Region: fur; PRK09462 498761006648 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498761006649 metal binding site 2 [ion binding]; metal-binding site 498761006650 putative DNA binding helix; other site 498761006651 metal binding site 1 [ion binding]; metal-binding site 498761006652 dimer interface [polypeptide binding]; other site 498761006653 structural Zn2+ binding site [ion binding]; other site 498761006654 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 498761006655 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 498761006656 Competence protein; Region: Competence; pfam03772 498761006657 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 498761006658 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 498761006659 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 498761006660 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 498761006661 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 498761006662 stage II sporulation protein P; Region: spore_II_P; TIGR02867 498761006663 integral membrane protein MviN; Region: mviN; TIGR01695 498761006664 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 498761006665 GTP-binding protein LepA; Provisional; Region: PRK05433 498761006666 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 498761006667 G1 box; other site 498761006668 putative GEF interaction site [polypeptide binding]; other site 498761006669 GTP/Mg2+ binding site [chemical binding]; other site 498761006670 Switch I region; other site 498761006671 G2 box; other site 498761006672 G3 box; other site 498761006673 Switch II region; other site 498761006674 G4 box; other site 498761006675 G5 box; other site 498761006676 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 498761006677 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 498761006678 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 498761006679 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 498761006680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761006681 FeS/SAM binding site; other site 498761006682 HemN C-terminal domain; Region: HemN_C; pfam06969 498761006683 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 498761006684 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 498761006685 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 498761006686 ring oligomerisation interface [polypeptide binding]; other site 498761006687 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 498761006688 ATP/Mg binding site [chemical binding]; other site 498761006689 hinge regions; other site 498761006690 stacking interactions; other site 498761006691 GrpE; Region: GrpE; pfam01025 498761006692 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 498761006693 dimer interface [polypeptide binding]; other site 498761006694 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 498761006695 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 498761006696 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 498761006697 nucleotide binding site [chemical binding]; other site 498761006698 NEF interaction site [polypeptide binding]; other site 498761006699 SBD interface [polypeptide binding]; other site 498761006700 chaperone protein DnaJ; Provisional; Region: PRK10767 498761006701 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 498761006702 HSP70 interaction site [polypeptide binding]; other site 498761006703 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 498761006704 substrate binding site [polypeptide binding]; other site 498761006705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 498761006706 Zn binding sites [ion binding]; other site 498761006707 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 498761006708 dimer interface [polypeptide binding]; other site 498761006709 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 498761006710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761006711 S-adenosylmethionine binding site [chemical binding]; other site 498761006712 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 498761006713 RNA methyltransferase, RsmE family; Region: TIGR00046 498761006714 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 498761006715 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 498761006716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761006717 FeS/SAM binding site; other site 498761006718 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 498761006719 nucleotide binding site/active site [active] 498761006720 HIT family signature motif; other site 498761006721 catalytic residue [active] 498761006722 Yqey-like protein; Region: YqeY; pfam09424 498761006723 YabP family; Region: YabP; cl06766 498761006724 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 498761006725 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 498761006726 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 498761006727 PhoH-like protein; Region: PhoH; pfam02562 498761006728 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 498761006729 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 498761006730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761006731 Zn2+ binding site [ion binding]; other site 498761006732 Mg2+ binding site [ion binding]; other site 498761006733 metal-binding heat shock protein; Provisional; Region: PRK00016 498761006734 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 498761006735 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 498761006736 active site 498761006737 catalytic motif [active] 498761006738 Zn binding site [ion binding]; other site 498761006739 GTPase Era; Reviewed; Region: era; PRK00089 498761006740 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 498761006741 G1 box; other site 498761006742 GTP/Mg2+ binding site [chemical binding]; other site 498761006743 Switch I region; other site 498761006744 G2 box; other site 498761006745 Switch II region; other site 498761006746 G3 box; other site 498761006747 G4 box; other site 498761006748 G5 box; other site 498761006749 KH domain; Region: KH_2; pfam07650 498761006750 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 498761006751 intersubunit interface [polypeptide binding]; other site 498761006752 active site 498761006753 catalytic residue [active] 498761006754 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 498761006755 Recombination protein O N terminal; Region: RecO_N; pfam11967 498761006756 Recombination protein O C terminal; Region: RecO_C; pfam02565 498761006757 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 498761006758 dimer interface [polypeptide binding]; other site 498761006759 motif 1; other site 498761006760 active site 498761006761 motif 2; other site 498761006762 motif 3; other site 498761006763 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 498761006764 DALR anticodon binding domain; Region: DALR_1; pfam05746 498761006765 HTH domain; Region: HTH_11; pfam08279 498761006766 FOG: CBS domain [General function prediction only]; Region: COG0517 498761006767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 498761006768 PEP synthetase regulatory protein; Provisional; Region: PRK05339 498761006769 pyruvate phosphate dikinase; Provisional; Region: PRK09279 498761006770 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 498761006771 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 498761006772 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 498761006773 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 498761006774 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 498761006775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761006776 S-adenosylmethionine binding site [chemical binding]; other site 498761006777 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 498761006778 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 498761006779 trimer interface [polypeptide binding]; other site 498761006780 putative metal binding site [ion binding]; other site 498761006781 3D domain; Region: 3D; cl01439 498761006782 YcfA-like protein; Region: YcfA; pfam07927 498761006783 Cell division protein FtsA; Region: FtsA; smart00842 498761006784 cell division protein FtsA; Region: ftsA; TIGR01174 498761006785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 498761006786 nucleotide binding site [chemical binding]; other site 498761006787 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 498761006788 trimer interface [polypeptide binding]; other site 498761006789 active site 498761006790 SpoVG; Region: SpoVG; cl00915 498761006791 SpoVG; Region: SpoVG; cl00915 498761006792 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 498761006793 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 498761006794 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 498761006795 homodimer interface [polypeptide binding]; other site 498761006796 substrate-cofactor binding pocket; other site 498761006797 catalytic residue [active] 498761006798 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 498761006799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498761006800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 498761006801 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 498761006802 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498761006803 Sulfatase; Region: Sulfatase; cl17466 498761006804 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 498761006805 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 498761006806 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 498761006807 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 498761006808 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 498761006809 substrate binding pocket [chemical binding]; other site 498761006810 dimer interface [polypeptide binding]; other site 498761006811 inhibitor binding site; inhibition site 498761006812 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 498761006813 B12 binding site [chemical binding]; other site 498761006814 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 498761006815 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 498761006816 AsnC family; Region: AsnC_trans_reg; pfam01037 498761006817 hypothetical protein; Validated; Region: PRK07682 498761006818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761006819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761006820 homodimer interface [polypeptide binding]; other site 498761006821 catalytic residue [active] 498761006822 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 498761006823 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498761006824 Beta-Casp domain; Region: Beta-Casp; smart01027 498761006825 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498761006826 4Fe-4S binding domain; Region: Fer4; cl02805 498761006827 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761006828 4Fe-4S binding domain; Region: Fer4; cl02805 498761006829 FeoA domain; Region: FeoA; pfam04023 498761006830 selenocysteine synthase; Provisional; Region: PRK04311 498761006831 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 498761006832 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 498761006833 dimerization interface [polypeptide binding]; other site 498761006834 putative ATP binding site [chemical binding]; other site 498761006835 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 498761006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 498761006837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761006838 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761006839 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498761006840 PAS domain; Region: PAS; smart00091 498761006841 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498761006842 putative active site [active] 498761006843 heme pocket [chemical binding]; other site 498761006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761006845 putative active site [active] 498761006846 heme pocket [chemical binding]; other site 498761006847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006848 Walker A motif; other site 498761006849 ATP binding site [chemical binding]; other site 498761006850 Walker B motif; other site 498761006851 arginine finger; other site 498761006852 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498761006853 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498761006854 germination protein YpeB; Region: spore_YpeB; TIGR02889 498761006855 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 498761006856 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761006857 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498761006858 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 498761006859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761006860 Response regulator receiver domain; Region: Response_reg; pfam00072 498761006861 active site 498761006862 phosphorylation site [posttranslational modification] 498761006863 intermolecular recognition site; other site 498761006864 dimerization interface [polypeptide binding]; other site 498761006865 ANTAR domain; Region: ANTAR; pfam03861 498761006866 Bacterial transcriptional regulator; Region: IclR; pfam01614 498761006867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761006868 dimer interface [polypeptide binding]; other site 498761006869 putative CheW interface [polypeptide binding]; other site 498761006870 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 498761006871 DHH family; Region: DHH; pfam01368 498761006872 DHHA1 domain; Region: DHHA1; pfam02272 498761006873 DNA polymerase IV; Reviewed; Region: PRK03103 498761006874 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 498761006875 active site 498761006876 DNA binding site [nucleotide binding] 498761006877 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 498761006878 S-layer homology domain; Region: SLH; pfam00395 498761006879 Transcriptional regulator [Transcription]; Region: LytR; COG1316 498761006880 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 498761006881 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 498761006882 homotetramer interface [polypeptide binding]; other site 498761006883 ligand binding site [chemical binding]; other site 498761006884 catalytic site [active] 498761006885 NAD binding site [chemical binding]; other site 498761006886 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 498761006887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498761006888 active site 498761006889 motif I; other site 498761006890 motif II; other site 498761006891 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 498761006892 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 498761006893 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 498761006894 DNA repair protein RecO; Region: reco; TIGR00613 498761006895 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 498761006896 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 498761006897 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 498761006898 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498761006899 metal binding site 2 [ion binding]; metal-binding site 498761006900 putative DNA binding helix; other site 498761006901 metal binding site 1 [ion binding]; metal-binding site 498761006902 dimer interface [polypeptide binding]; other site 498761006903 structural Zn2+ binding site [ion binding]; other site 498761006904 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761006905 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761006906 putative active site [active] 498761006907 putative NTP binding site [chemical binding]; other site 498761006908 putative nucleic acid binding site [nucleotide binding]; other site 498761006909 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761006910 Domain of unknown function (DUF366); Region: DUF366; pfam04017 498761006911 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 498761006912 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 498761006913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761006914 FeS/SAM binding site; other site 498761006915 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 498761006916 homodecamer interface [polypeptide binding]; other site 498761006917 GTP cyclohydrolase I; Provisional; Region: PLN03044 498761006918 active site 498761006919 putative catalytic site residues [active] 498761006920 zinc binding site [ion binding]; other site 498761006921 GTP-CH-I/GFRP interaction surface; other site 498761006922 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 498761006923 putative active site pocket [active] 498761006924 dimerization interface [polypeptide binding]; other site 498761006925 putative catalytic residue [active] 498761006926 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 498761006927 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 498761006928 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498761006929 integral membrane protein MviN; Region: mviN; TIGR01695 498761006930 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 498761006931 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 498761006932 elongation factor G; Reviewed; Region: PRK12740 498761006933 G1 box; other site 498761006934 putative GEF interaction site [polypeptide binding]; other site 498761006935 GTP/Mg2+ binding site [chemical binding]; other site 498761006936 Switch I region; other site 498761006937 G2 box; other site 498761006938 G3 box; other site 498761006939 Switch II region; other site 498761006940 G4 box; other site 498761006941 G5 box; other site 498761006942 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 498761006943 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 498761006944 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 498761006945 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 498761006946 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498761006947 active site 498761006948 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498761006949 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 498761006950 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761006951 acyl-activating enzyme (AAE) consensus motif; other site 498761006952 AMP binding site [chemical binding]; other site 498761006953 active site 498761006954 CoA binding site [chemical binding]; other site 498761006955 ACT domain-containing protein [General function prediction only]; Region: COG4747 498761006956 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 498761006957 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 498761006958 Uncharacterized conserved protein [Function unknown]; Region: COG1615 498761006959 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 498761006960 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761006961 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498761006962 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 498761006963 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 498761006964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498761006965 LexA repressor; Validated; Region: PRK00215 498761006966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761006967 putative Zn2+ binding site [ion binding]; other site 498761006968 putative DNA binding site [nucleotide binding]; other site 498761006969 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 498761006970 Catalytic site [active] 498761006971 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 498761006972 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 498761006973 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 498761006974 Protein of unknown function (DUF456); Region: DUF456; pfam04306 498761006975 Aluminium resistance protein; Region: Alum_res; pfam06838 498761006976 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 498761006977 GTPases [General function prediction only]; Region: HflX; COG2262 498761006978 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 498761006979 HflX GTPase family; Region: HflX; cd01878 498761006980 G1 box; other site 498761006981 GTP/Mg2+ binding site [chemical binding]; other site 498761006982 Switch I region; other site 498761006983 G2 box; other site 498761006984 G3 box; other site 498761006985 Switch II region; other site 498761006986 G4 box; other site 498761006987 G5 box; other site 498761006988 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761006989 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761006990 putative active site [active] 498761006991 putative NTP binding site [chemical binding]; other site 498761006992 putative nucleic acid binding site [nucleotide binding]; other site 498761006993 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761006994 stage V sporulation protein K; Region: spore_V_K; TIGR02881 498761006995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761006996 Walker A motif; other site 498761006997 ATP binding site [chemical binding]; other site 498761006998 Walker B motif; other site 498761006999 arginine finger; other site 498761007000 bacterial Hfq-like; Region: Hfq; cd01716 498761007001 hexamer interface [polypeptide binding]; other site 498761007002 Sm1 motif; other site 498761007003 RNA binding site [nucleotide binding]; other site 498761007004 Sm2 motif; other site 498761007005 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 498761007006 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 498761007007 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 498761007008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007009 ATP binding site [chemical binding]; other site 498761007010 Mg2+ binding site [ion binding]; other site 498761007011 G-X-G motif; other site 498761007012 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 498761007013 ATP binding site [chemical binding]; other site 498761007014 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 498761007015 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 498761007016 MutS domain I; Region: MutS_I; pfam01624 498761007017 MutS domain II; Region: MutS_II; pfam05188 498761007018 MutS domain III; Region: MutS_III; pfam05192 498761007019 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 498761007020 Walker A/P-loop; other site 498761007021 ATP binding site [chemical binding]; other site 498761007022 Q-loop/lid; other site 498761007023 ABC transporter signature motif; other site 498761007024 Walker B; other site 498761007025 D-loop; other site 498761007026 H-loop/switch region; other site 498761007027 PAS domain S-box; Region: sensory_box; TIGR00229 498761007028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761007029 putative active site [active] 498761007030 heme pocket [chemical binding]; other site 498761007031 PAS domain S-box; Region: sensory_box; TIGR00229 498761007032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761007033 putative active site [active] 498761007034 heme pocket [chemical binding]; other site 498761007035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761007036 dimer interface [polypeptide binding]; other site 498761007037 phosphorylation site [posttranslational modification] 498761007038 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 498761007039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007040 ATP binding site [chemical binding]; other site 498761007041 Mg2+ binding site [ion binding]; other site 498761007042 G-X-G motif; other site 498761007043 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761007044 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761007045 putative active site [active] 498761007046 putative NTP binding site [chemical binding]; other site 498761007047 putative nucleic acid binding site [nucleotide binding]; other site 498761007048 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761007049 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 498761007050 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 498761007051 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 498761007052 active site 498761007053 catalytic residues [active] 498761007054 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 498761007055 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 498761007056 oligomer interface [polypeptide binding]; other site 498761007057 metal binding site [ion binding]; metal-binding site 498761007058 metal binding site [ion binding]; metal-binding site 498761007059 putative Cl binding site [ion binding]; other site 498761007060 aspartate ring; other site 498761007061 basic sphincter; other site 498761007062 hydrophobic gate; other site 498761007063 periplasmic entrance; other site 498761007064 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 498761007065 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 498761007066 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 498761007067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761007068 dimer interface [polypeptide binding]; other site 498761007069 putative CheW interface [polypeptide binding]; other site 498761007070 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 498761007071 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 498761007072 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 498761007073 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 498761007074 SLBB domain; Region: SLBB; pfam10531 498761007075 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 498761007076 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 498761007077 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498761007078 anti sigma factor interaction site; other site 498761007079 regulatory phosphorylation site [posttranslational modification]; other site 498761007080 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 498761007081 4Fe-4S binding domain; Region: Fer4; pfam00037 498761007082 4Fe-4S binding domain; Region: Fer4; pfam00037 498761007083 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498761007084 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761007085 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761007086 putative active site [active] 498761007087 putative NTP binding site [chemical binding]; other site 498761007088 putative nucleic acid binding site [nucleotide binding]; other site 498761007089 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761007090 FAD binding domain; Region: FAD_binding_4; pfam01565 498761007091 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 498761007092 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498761007093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498761007094 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498761007095 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498761007096 Ligand binding site [chemical binding]; other site 498761007097 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498761007098 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 498761007099 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 498761007100 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 498761007101 dimerization interface [polypeptide binding]; other site 498761007102 ATP binding site [chemical binding]; other site 498761007103 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 498761007104 dimerization interface [polypeptide binding]; other site 498761007105 ATP binding site [chemical binding]; other site 498761007106 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 498761007107 putative active site [active] 498761007108 catalytic triad [active] 498761007109 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 498761007110 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 498761007111 NodB motif; other site 498761007112 active site 498761007113 catalytic site [active] 498761007114 Cd binding site [ion binding]; other site 498761007115 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 498761007116 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 498761007117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761007118 dimer interface [polypeptide binding]; other site 498761007119 putative CheW interface [polypeptide binding]; other site 498761007120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 498761007121 putative binding surface; other site 498761007122 active site 498761007123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007124 ATP binding site [chemical binding]; other site 498761007125 Mg2+ binding site [ion binding]; other site 498761007126 G-X-G motif; other site 498761007127 Response regulator receiver domain; Region: Response_reg; pfam00072 498761007128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761007129 active site 498761007130 phosphorylation site [posttranslational modification] 498761007131 intermolecular recognition site; other site 498761007132 dimerization interface [polypeptide binding]; other site 498761007133 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 498761007134 Transposase domain (DUF772); Region: DUF772; pfam05598 498761007135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761007136 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761007137 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 498761007138 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 498761007139 active site 498761007140 FMN binding site [chemical binding]; other site 498761007141 substrate binding site [chemical binding]; other site 498761007142 3Fe-4S cluster binding site [ion binding]; other site 498761007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761007144 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761007145 Walker A motif; other site 498761007146 ATP binding site [chemical binding]; other site 498761007147 Walker B motif; other site 498761007148 arginine finger; other site 498761007149 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 498761007150 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 498761007151 putative catalytic cysteine [active] 498761007152 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 498761007153 putative active site [active] 498761007154 metal binding site [ion binding]; metal-binding site 498761007155 Response regulator receiver domain; Region: Response_reg; pfam00072 498761007156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761007157 active site 498761007158 phosphorylation site [posttranslational modification] 498761007159 intermolecular recognition site; other site 498761007160 dimerization interface [polypeptide binding]; other site 498761007161 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498761007162 putative binding surface; other site 498761007163 active site 498761007164 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 498761007165 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 498761007166 XdhC Rossmann domain; Region: XdhC_C; pfam13478 498761007167 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 498761007168 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 498761007169 putative MPT binding site; other site 498761007170 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 498761007171 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 498761007172 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 498761007173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498761007174 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498761007175 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498761007176 phenylhydantoinase; Validated; Region: PRK08323 498761007177 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 498761007178 tetramer interface [polypeptide binding]; other site 498761007179 active site 498761007180 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 498761007181 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 498761007182 putative substrate binding site [chemical binding]; other site 498761007183 nucleotide binding site [chemical binding]; other site 498761007184 nucleotide binding site [chemical binding]; other site 498761007185 homodimer interface [polypeptide binding]; other site 498761007186 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 498761007187 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498761007188 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498761007189 peptidase; Reviewed; Region: PRK13004 498761007190 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 498761007191 putative metal binding site [ion binding]; other site 498761007192 putative dimer interface [polypeptide binding]; other site 498761007193 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 498761007194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498761007195 catalytic loop [active] 498761007196 iron binding site [ion binding]; other site 498761007197 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498761007198 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 498761007199 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 498761007200 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 498761007201 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498761007202 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498761007203 Transposase domain (DUF772); Region: DUF772; pfam05598 498761007204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761007205 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761007206 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 498761007207 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 498761007208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498761007209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498761007210 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 498761007211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498761007212 active site 498761007213 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 498761007214 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498761007215 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 498761007216 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 498761007217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761007218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761007219 ABC transporter; Region: ABC_tran_2; pfam12848 498761007220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498761007221 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 498761007222 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761007223 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761007224 putative active site [active] 498761007225 putative NTP binding site [chemical binding]; other site 498761007226 putative nucleic acid binding site [nucleotide binding]; other site 498761007227 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761007228 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498761007229 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 498761007230 Na binding site [ion binding]; other site 498761007231 Protein of unknown function, DUF485; Region: DUF485; pfam04341 498761007232 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498761007233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761007234 active site 498761007235 phosphorylation site [posttranslational modification] 498761007236 intermolecular recognition site; other site 498761007237 dimerization interface [polypeptide binding]; other site 498761007238 LytTr DNA-binding domain; Region: LytTR; smart00850 498761007239 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 498761007240 Histidine kinase; Region: His_kinase; pfam06580 498761007241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007242 ATP binding site [chemical binding]; other site 498761007243 Mg2+ binding site [ion binding]; other site 498761007244 G-X-G motif; other site 498761007245 GntP family permease; Region: GntP_permease; pfam02447 498761007246 fructuronate transporter; Provisional; Region: PRK10034; cl15264 498761007247 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 498761007248 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 498761007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 498761007250 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 498761007251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498761007252 DNA-binding site [nucleotide binding]; DNA binding site 498761007253 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498761007254 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 498761007255 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 498761007256 dimer interface [polypeptide binding]; other site 498761007257 putative functional site; other site 498761007258 putative MPT binding site; other site 498761007259 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 498761007260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 498761007261 dimer interface [polypeptide binding]; other site 498761007262 putative functional site; other site 498761007263 putative MPT binding site; other site 498761007264 PBP superfamily domain; Region: PBP_like; pfam12727 498761007265 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 498761007266 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 498761007267 HIGH motif; other site 498761007268 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 498761007269 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 498761007270 active site 498761007271 KMSKS motif; other site 498761007272 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 498761007273 tRNA binding surface [nucleotide binding]; other site 498761007274 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 498761007275 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 498761007276 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498761007277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498761007278 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 498761007279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761007280 S-adenosylmethionine binding site [chemical binding]; other site 498761007281 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761007282 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 498761007283 active site 498761007284 Transcriptional regulators [Transcription]; Region: MarR; COG1846 498761007285 MarR family; Region: MarR_2; cl17246 498761007286 MarR family; Region: MarR_2; cl17246 498761007287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498761007288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498761007289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761007290 Walker A/P-loop; other site 498761007291 ATP binding site [chemical binding]; other site 498761007292 Q-loop/lid; other site 498761007293 ABC transporter signature motif; other site 498761007294 Walker B; other site 498761007295 D-loop; other site 498761007296 H-loop/switch region; other site 498761007297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498761007298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498761007299 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 498761007300 Walker A/P-loop; other site 498761007301 ATP binding site [chemical binding]; other site 498761007302 Q-loop/lid; other site 498761007303 ABC transporter signature motif; other site 498761007304 Walker B; other site 498761007305 D-loop; other site 498761007306 H-loop/switch region; other site 498761007307 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 498761007308 Ligand binding site; other site 498761007309 metal-binding site 498761007310 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 498761007311 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 498761007312 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 498761007313 active site 498761007314 putative substrate binding pocket [chemical binding]; other site 498761007315 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761007316 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 498761007317 TM-ABC transporter signature motif; other site 498761007318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498761007319 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 498761007320 TM-ABC transporter signature motif; other site 498761007321 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 498761007322 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 498761007323 Walker A/P-loop; other site 498761007324 ATP binding site [chemical binding]; other site 498761007325 Q-loop/lid; other site 498761007326 ABC transporter signature motif; other site 498761007327 Walker B; other site 498761007328 D-loop; other site 498761007329 H-loop/switch region; other site 498761007330 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 498761007331 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 498761007332 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 498761007333 putative ligand binding site [chemical binding]; other site 498761007334 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 498761007335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761007336 catalytic residue [active] 498761007337 threonine synthase; Validated; Region: PRK06260 498761007338 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 498761007339 homodimer interface [polypeptide binding]; other site 498761007340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761007341 catalytic residue [active] 498761007342 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 498761007343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761007344 Zn2+ binding site [ion binding]; other site 498761007345 Mg2+ binding site [ion binding]; other site 498761007346 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 498761007347 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 498761007348 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 498761007349 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 498761007350 active site 498761007351 (T/H)XGH motif; other site 498761007352 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 498761007353 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 498761007354 putative catalytic cysteine [active] 498761007355 gamma-glutamyl kinase; Provisional; Region: PRK05429 498761007356 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 498761007357 nucleotide binding site [chemical binding]; other site 498761007358 homotetrameric interface [polypeptide binding]; other site 498761007359 putative phosphate binding site [ion binding]; other site 498761007360 putative allosteric binding site; other site 498761007361 PUA domain; Region: PUA; pfam01472 498761007362 GTPase CgtA; Reviewed; Region: obgE; PRK12297 498761007363 GTP1/OBG; Region: GTP1_OBG; pfam01018 498761007364 Obg GTPase; Region: Obg; cd01898 498761007365 G1 box; other site 498761007366 GTP/Mg2+ binding site [chemical binding]; other site 498761007367 Switch I region; other site 498761007368 G2 box; other site 498761007369 G3 box; other site 498761007370 Switch II region; other site 498761007371 G4 box; other site 498761007372 G5 box; other site 498761007373 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 498761007374 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 498761007375 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761007376 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761007377 putative active site [active] 498761007378 putative NTP binding site [chemical binding]; other site 498761007379 putative nucleic acid binding site [nucleotide binding]; other site 498761007380 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761007381 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 498761007382 Protein of unknown function (DUF464); Region: DUF464; pfam04327 498761007383 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 498761007384 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 498761007385 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 498761007386 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 498761007387 homodimer interface [polypeptide binding]; other site 498761007388 oligonucleotide binding site [chemical binding]; other site 498761007389 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 498761007390 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 498761007391 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 498761007392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498761007393 FeS/SAM binding site; other site 498761007394 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 498761007395 Peptidase family M50; Region: Peptidase_M50; pfam02163 498761007396 active site 498761007397 putative substrate binding region [chemical binding]; other site 498761007398 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498761007399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498761007400 Peptidase family M23; Region: Peptidase_M23; pfam01551 498761007401 amino acid transporter; Region: 2A0306; TIGR00909 498761007402 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 498761007403 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761007404 AMIN domain; Region: AMIN; pfam11741 498761007405 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498761007406 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498761007407 active site 498761007408 metal binding site [ion binding]; metal-binding site 498761007409 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 498761007410 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 498761007411 active site 498761007412 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 498761007413 Flagellar protein YcgR; Region: YcgR_2; pfam12945 498761007414 PilZ domain; Region: PilZ; pfam07238 498761007415 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 498761007416 Septum formation topological specificity factor MinE; Region: MinE; cl00538 498761007417 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 498761007418 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 498761007419 Switch I; other site 498761007420 Switch II; other site 498761007421 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 498761007422 penicillin-binding protein 2; Provisional; Region: PRK10795 498761007423 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498761007424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498761007425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498761007426 rod shape-determining protein MreC; Provisional; Region: PRK13922 498761007427 rod shape-determining protein MreC; Region: MreC; pfam04085 498761007428 rod shape-determining protein MreB; Provisional; Region: PRK13927 498761007429 MreB and similar proteins; Region: MreB_like; cd10225 498761007430 nucleotide binding site [chemical binding]; other site 498761007431 Mg binding site [ion binding]; other site 498761007432 putative protofilament interaction site [polypeptide binding]; other site 498761007433 RodZ interaction site [polypeptide binding]; other site 498761007434 hypothetical protein; Reviewed; Region: PRK00024 498761007435 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 498761007436 MPN+ (JAMM) motif; other site 498761007437 Zinc-binding site [ion binding]; other site 498761007438 Maf-like protein; Region: Maf; pfam02545 498761007439 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 498761007440 active site 498761007441 dimer interface [polypeptide binding]; other site 498761007442 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 498761007443 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 498761007444 B12 binding site [chemical binding]; other site 498761007445 Transposase domain (DUF772); Region: DUF772; pfam05598 498761007446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761007447 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761007448 Glucose inhibited division protein A; Region: GIDA; pfam01134 498761007449 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 498761007450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498761007451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498761007452 catalytic residue [active] 498761007453 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 498761007454 homotrimer interaction site [polypeptide binding]; other site 498761007455 putative active site [active] 498761007456 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 498761007457 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 498761007458 CoA binding domain; Region: CoA_binding; smart00881 498761007459 Phosphate transporter family; Region: PHO4; pfam01384 498761007460 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 498761007461 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 498761007462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498761007463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498761007464 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 498761007465 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 498761007466 HIGH motif; other site 498761007467 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 498761007468 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 498761007469 active site 498761007470 KMSKS motif; other site 498761007471 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 498761007472 tRNA binding surface [nucleotide binding]; other site 498761007473 anticodon binding site; other site 498761007474 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 498761007475 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 498761007476 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 498761007477 Walker A; other site 498761007478 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 498761007479 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 498761007480 active site residue [active] 498761007481 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 498761007482 oligomerization interface [polypeptide binding]; other site 498761007483 active site 498761007484 metal binding site [ion binding]; metal-binding site 498761007485 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 498761007486 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 498761007487 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 498761007488 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 498761007489 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 498761007490 NAD binding site [chemical binding]; other site 498761007491 dimer interface [polypeptide binding]; other site 498761007492 substrate binding site [chemical binding]; other site 498761007493 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498761007494 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 498761007495 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 498761007496 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 498761007497 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 498761007498 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 498761007499 TPP-binding site [chemical binding]; other site 498761007500 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498761007501 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 498761007502 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 498761007503 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498761007504 dimer interface [polypeptide binding]; other site 498761007505 PYR/PP interface [polypeptide binding]; other site 498761007506 TPP binding site [chemical binding]; other site 498761007507 substrate binding site [chemical binding]; other site 498761007508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498761007509 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 498761007510 Ferredoxin [Energy production and conversion]; Region: COG1146 498761007511 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498761007512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 498761007513 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 498761007514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761007515 dimer interface [polypeptide binding]; other site 498761007516 phosphorylation site [posttranslational modification] 498761007517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007518 ATP binding site [chemical binding]; other site 498761007519 Mg2+ binding site [ion binding]; other site 498761007520 G-X-G motif; other site 498761007521 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498761007522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761007523 active site 498761007524 phosphorylation site [posttranslational modification] 498761007525 intermolecular recognition site; other site 498761007526 dimerization interface [polypeptide binding]; other site 498761007527 Hpt domain; Region: Hpt; pfam01627 498761007528 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 498761007529 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 498761007530 NodB motif; other site 498761007531 putative active site [active] 498761007532 putative catalytic site [active] 498761007533 putative Zn binding site [ion binding]; other site 498761007534 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498761007535 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 498761007536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761007537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761007538 DNA binding residues [nucleotide binding] 498761007539 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 498761007540 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 498761007541 active site 498761007542 metal-binding site [ion binding] 498761007543 nucleotide-binding site [chemical binding]; other site 498761007544 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 498761007545 CHAD domain; Region: CHAD; pfam05235 498761007546 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 498761007547 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 498761007548 dimer interface [polypeptide binding]; other site 498761007549 active site 498761007550 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 498761007551 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761007552 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761007553 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 498761007554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498761007555 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498761007556 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 498761007557 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 498761007558 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 498761007559 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 498761007560 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 498761007561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761007562 Walker A motif; other site 498761007563 ATP binding site [chemical binding]; other site 498761007564 Walker B motif; other site 498761007565 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 498761007566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 498761007567 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 498761007568 [4Fe-4S] binding site [ion binding]; other site 498761007569 molybdopterin cofactor binding site; other site 498761007570 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 498761007571 molybdopterin cofactor binding site; other site 498761007572 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498761007573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498761007574 dimerization interface [polypeptide binding]; other site 498761007575 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498761007576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761007577 dimer interface [polypeptide binding]; other site 498761007578 putative CheW interface [polypeptide binding]; other site 498761007579 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 498761007580 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 498761007581 putative acyl-acceptor binding pocket; other site 498761007582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498761007583 acyl-activating enzyme (AAE) consensus motif; other site 498761007584 AMP binding site [chemical binding]; other site 498761007585 active site 498761007586 CoA binding site [chemical binding]; other site 498761007587 4Fe-4S binding domain; Region: Fer4; pfam00037 498761007588 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 498761007589 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 498761007590 oligomer interface [polypeptide binding]; other site 498761007591 putative Cl binding site [ion binding]; other site 498761007592 aspartate ring; other site 498761007593 basic sphincter; other site 498761007594 hydrophobic gate; other site 498761007595 periplasmic entrance; other site 498761007596 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 498761007597 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 498761007598 active site 498761007599 HIGH motif; other site 498761007600 nucleotide binding site [chemical binding]; other site 498761007601 active site 498761007602 KMSKS motif; other site 498761007603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 498761007604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498761007605 metal-binding site [ion binding] 498761007606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498761007607 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498761007608 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 498761007609 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 498761007610 NAD binding site [chemical binding]; other site 498761007611 ligand binding site [chemical binding]; other site 498761007612 catalytic site [active] 498761007613 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 498761007614 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 498761007615 minor groove reading motif; other site 498761007616 helix-hairpin-helix signature motif; other site 498761007617 substrate binding pocket [chemical binding]; other site 498761007618 active site 498761007619 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 498761007620 Carbohydrate binding domain; Region: CBM_25; smart01066 498761007621 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 498761007622 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 498761007623 Rubredoxin; Region: Rubredoxin; pfam00301 498761007624 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 498761007625 iron binding site [ion binding]; other site 498761007626 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 498761007627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 498761007628 active site 498761007629 catalytic tetrad [active] 498761007630 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498761007631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761007632 non-specific DNA binding site [nucleotide binding]; other site 498761007633 salt bridge; other site 498761007634 sequence-specific DNA binding site [nucleotide binding]; other site 498761007635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498761007636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498761007637 non-specific DNA binding site [nucleotide binding]; other site 498761007638 salt bridge; other site 498761007639 sequence-specific DNA binding site [nucleotide binding]; other site 498761007640 NAD synthetase; Provisional; Region: PRK13981 498761007641 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 498761007642 multimer interface [polypeptide binding]; other site 498761007643 active site 498761007644 catalytic triad [active] 498761007645 protein interface 1 [polypeptide binding]; other site 498761007646 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 498761007647 homodimer interface [polypeptide binding]; other site 498761007648 NAD binding pocket [chemical binding]; other site 498761007649 ATP binding pocket [chemical binding]; other site 498761007650 Mg binding site [ion binding]; other site 498761007651 active-site loop [active] 498761007652 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498761007653 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498761007654 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498761007655 active site 498761007656 metal binding site [ion binding]; metal-binding site 498761007657 S-layer homology domain; Region: SLH; pfam00395 498761007658 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 498761007659 RNA/DNA hybrid binding site [nucleotide binding]; other site 498761007660 active site 498761007661 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 498761007662 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 498761007663 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498761007664 protein binding site [polypeptide binding]; other site 498761007665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498761007666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498761007667 active site 498761007668 phosphorylation site [posttranslational modification] 498761007669 intermolecular recognition site; other site 498761007670 dimerization interface [polypeptide binding]; other site 498761007671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498761007672 DNA binding site [nucleotide binding] 498761007673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 498761007674 dimerization interface [polypeptide binding]; other site 498761007675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498761007676 dimer interface [polypeptide binding]; other site 498761007677 phosphorylation site [posttranslational modification] 498761007678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498761007679 ATP binding site [chemical binding]; other site 498761007680 Mg2+ binding site [ion binding]; other site 498761007681 G-X-G motif; other site 498761007682 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 498761007683 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 498761007684 transmembrane helices; other site 498761007685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761007686 TPR motif; other site 498761007687 binding surface 498761007688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498761007689 binding surface 498761007690 TPR motif; other site 498761007691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 498761007692 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 498761007693 active site 498761007694 ATP binding site [chemical binding]; other site 498761007695 substrate binding site [chemical binding]; other site 498761007696 activation loop (A-loop); other site 498761007697 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 498761007698 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 498761007699 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498761007700 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498761007701 G1 box; other site 498761007702 GTP/Mg2+ binding site [chemical binding]; other site 498761007703 Switch I region; other site 498761007704 G2 box; other site 498761007705 G3 box; other site 498761007706 Switch II region; other site 498761007707 G4 box; other site 498761007708 G5 box; other site 498761007709 Nucleoside recognition; Region: Gate; pfam07670 498761007710 Nucleoside recognition; Region: Gate; pfam07670 498761007711 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498761007712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498761007713 Walker A/P-loop; other site 498761007714 ATP binding site [chemical binding]; other site 498761007715 Q-loop/lid; other site 498761007716 ABC transporter signature motif; other site 498761007717 Walker B; other site 498761007718 D-loop; other site 498761007719 H-loop/switch region; other site 498761007720 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498761007721 ABC-2 type transporter; Region: ABC2_membrane; cl17235 498761007722 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498761007723 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 498761007724 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 498761007725 Ligand Binding Site [chemical binding]; other site 498761007726 RelB antitoxin; Region: RelB; cl01171 498761007727 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761007728 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 498761007729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761007730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761007731 DNA binding residues [nucleotide binding] 498761007732 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 498761007733 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 498761007734 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 498761007735 cofactor binding site; other site 498761007736 DNA binding site [nucleotide binding] 498761007737 substrate interaction site [chemical binding]; other site 498761007738 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 498761007739 additional DNA contacts [nucleotide binding]; other site 498761007740 mismatch recognition site; other site 498761007741 active site 498761007742 zinc binding site [ion binding]; other site 498761007743 DNA intercalation site [nucleotide binding]; other site 498761007744 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 498761007745 active site 498761007746 catalytic triad [active] 498761007747 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498761007748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498761007749 Walker A motif; other site 498761007750 ATP binding site [chemical binding]; other site 498761007751 Walker B motif; other site 498761007752 arginine finger; other site 498761007753 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761007754 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761007755 catalytic residues [active] 498761007756 catalytic nucleophile [active] 498761007757 Recombinase; Region: Recombinase; pfam07508 498761007758 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761007759 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761007760 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761007761 catalytic residues [active] 498761007762 catalytic nucleophile [active] 498761007763 Recombinase; Region: Recombinase; pfam07508 498761007764 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761007765 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 498761007766 amidase catalytic site [active] 498761007767 Zn binding residues [ion binding]; other site 498761007768 substrate binding site [chemical binding]; other site 498761007769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761007770 Holin family; Region: Phage_holin_4; pfam05105 498761007771 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 498761007772 active site 498761007773 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 498761007774 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 498761007775 Phage-related protein [Function unknown]; Region: COG4722 498761007776 Phage tail protein; Region: Sipho_tail; pfam05709 498761007777 Phage-related minor tail protein [Function unknown]; Region: COG5280 498761007778 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 498761007779 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 498761007780 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 498761007781 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 498761007782 oligomerization interface [polypeptide binding]; other site 498761007783 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 498761007784 Phage capsid family; Region: Phage_capsid; pfam05065 498761007785 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 498761007786 oligomer interface [polypeptide binding]; other site 498761007787 active site residues [active] 498761007788 Phage-related protein [Function unknown]; Region: COG4695 498761007789 Phage portal protein; Region: Phage_portal; pfam04860 498761007790 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 498761007791 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 498761007792 putative active site pocket [active] 498761007793 dimerization interface [polypeptide binding]; other site 498761007794 putative catalytic residue [active] 498761007795 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 498761007796 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 498761007797 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 498761007798 ParB-like nuclease domain; Region: ParB; smart00470 498761007799 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 498761007800 DNA methylase; Region: N6_N4_Mtase; pfam01555 498761007801 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 498761007802 ParB-like nuclease domain; Region: ParBc; pfam02195 498761007803 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 498761007804 DNA methylase; Region: N6_N4_Mtase; pfam01555 498761007805 Phage terminase, small subunit; Region: Terminase_4; cl01525 498761007806 VRR-NUC domain; Region: VRR_NUC; pfam08774 498761007807 D5 N terminal like; Region: D5_N; smart00885 498761007808 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 498761007809 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 498761007810 G1 box; other site 498761007811 GTP/Mg2+ binding site [chemical binding]; other site 498761007812 RFX DNA-binding domain; Region: RFX_DNA_binding; pfam02257 498761007813 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 498761007814 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 498761007815 active site 498761007816 catalytic site [active] 498761007817 substrate binding site [chemical binding]; other site 498761007818 DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication; Region: DNA_pol_A_plastid_like; cd08640 498761007819 active site 498761007820 DNA binding site [nucleotide binding] 498761007821 catalytic site [active] 498761007822 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 498761007823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761007824 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498761007825 ATP binding site [chemical binding]; other site 498761007826 putative Mg++ binding site [ion binding]; other site 498761007827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761007828 nucleotide binding region [chemical binding]; other site 498761007829 ATP-binding site [chemical binding]; other site 498761007830 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761007831 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 498761007832 Penicillinase repressor; Region: Pencillinase_R; cl17580 498761007833 Putative amidase domain; Region: Amidase_6; pfam12671 498761007834 Putative amidase domain; Region: Amidase_6; pfam12671 498761007835 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 498761007836 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498761007837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498761007838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498761007839 DNA binding residues [nucleotide binding] 498761007840 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 498761007841 Penicillinase repressor; Region: Pencillinase_R; pfam03965 498761007842 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 498761007843 Uncharacterized conserved protein [Function unknown]; Region: COG1479 498761007844 Protein of unknown function DUF262; Region: DUF262; pfam03235 498761007845 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 498761007846 DEAD-like helicases superfamily; Region: DEXDc; smart00487 498761007847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761007848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761007849 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 498761007850 DNA methylase; Region: N6_N4_Mtase; pfam01555 498761007851 DNA methylase; Region: N6_N4_Mtase; cl17433 498761007852 Predicted ATPase [General function prediction only]; Region: COG5293 498761007853 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 498761007854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 498761007855 DNA binding residues [nucleotide binding] 498761007856 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 498761007857 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 498761007858 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 498761007859 active site 498761007860 DNA binding site [nucleotide binding] 498761007861 catalytic site [active] 498761007862 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 498761007863 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 498761007864 Virulence-associated protein E; Region: VirE; pfam05272 498761007865 VRR-NUC domain; Region: VRR_NUC; pfam08774 498761007866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761007867 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 498761007868 ATP binding site [chemical binding]; other site 498761007869 putative Mg++ binding site [ion binding]; other site 498761007870 Phage terminase, small subunit; Region: Terminase_4; cl01525 498761007871 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 498761007872 ParB-like nuclease domain; Region: ParBc; pfam02195 498761007873 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 498761007874 DNA methylase; Region: N6_N4_Mtase; pfam01555 498761007875 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 498761007876 cofactor binding site; other site 498761007877 DNA binding site [nucleotide binding] 498761007878 substrate interaction site [chemical binding]; other site 498761007879 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 498761007880 Transposase domain (DUF772); Region: DUF772; pfam05598 498761007881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761007882 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761007883 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 498761007884 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761007885 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 498761007886 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 498761007887 Int/Topo IB signature motif; other site 498761007888 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 498761007889 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761007890 active site 498761007891 DNA binding site [nucleotide binding] 498761007892 Int/Topo IB signature motif; other site 498761007893 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498761007894 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498761007895 active site 498761007896 DNA binding site [nucleotide binding] 498761007897 Int/Topo IB signature motif; other site 498761007898 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 498761007899 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 498761007900 putative active site pocket [active] 498761007901 dimerization interface [polypeptide binding]; other site 498761007902 putative catalytic residue [active] 498761007903 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 498761007904 Phage-related protein [Function unknown]; Region: COG4695 498761007905 Phage portal protein; Region: Phage_portal; pfam04860 498761007906 Clp protease; Region: CLP_protease; pfam00574 498761007907 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 498761007908 oligomer interface [polypeptide binding]; other site 498761007909 active site residues [active] 498761007910 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 498761007911 Phage capsid family; Region: Phage_capsid; pfam05065 498761007912 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 498761007913 oligomerization interface [polypeptide binding]; other site 498761007914 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 498761007915 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 498761007916 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 498761007917 Phage-related protein [Function unknown]; Region: COG5412 498761007918 Phage-related protein [Function unknown]; Region: COG4722 498761007919 Phage tail protein; Region: Sipho_tail; pfam05709 498761007920 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 498761007921 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 498761007922 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 498761007923 active site 498761007924 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 498761007925 Holin family; Region: Phage_holin_4; pfam05105 498761007926 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 498761007927 amidase catalytic site [active] 498761007928 Zn binding residues [ion binding]; other site 498761007929 substrate binding site [chemical binding]; other site 498761007930 Sporulation related domain; Region: SPOR; pfam05036 498761007931 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761007932 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761007933 catalytic residues [active] 498761007934 catalytic nucleophile [active] 498761007935 Recombinase; Region: Recombinase; pfam07508 498761007936 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761007937 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 498761007938 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 498761007939 catalytic residues [active] 498761007940 catalytic nucleophile [active] 498761007941 Recombinase; Region: Recombinase; pfam07508 498761007942 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 498761007943 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 498761007944 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498761007945 DNA binding residues [nucleotide binding] 498761007946 TRAM domain; Region: TRAM; cl01282 498761007947 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 498761007948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498761007949 S-adenosylmethionine binding site [chemical binding]; other site 498761007950 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 498761007951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498761007952 active site 498761007953 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498761007954 CAAX protease self-immunity; Region: Abi; pfam02517 498761007955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 498761007956 Uncharacterized conserved protein [Function unknown]; Region: COG1543 498761007957 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 498761007958 active site 498761007959 substrate binding site [chemical binding]; other site 498761007960 catalytic site [active] 498761007961 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 498761007962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498761007963 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 498761007964 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 498761007965 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 498761007966 active site 498761007967 catalytic residues [active] 498761007968 metal binding site [ion binding]; metal-binding site 498761007969 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 498761007970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498761007971 catalytic triad [active] 498761007972 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 498761007973 Part of AAA domain; Region: AAA_19; pfam13245 498761007974 Family description; Region: UvrD_C_2; pfam13538 498761007975 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 498761007976 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 498761007977 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 498761007978 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 498761007979 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 498761007980 generic binding surface I; other site 498761007981 generic binding surface II; other site 498761007982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498761007983 Zn2+ binding site [ion binding]; other site 498761007984 Mg2+ binding site [ion binding]; other site 498761007985 Uncharacterized conserved protein [Function unknown]; Region: COG2966 498761007986 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 498761007987 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 498761007988 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498761007989 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498761007990 Walker A/P-loop; other site 498761007991 ATP binding site [chemical binding]; other site 498761007992 Q-loop/lid; other site 498761007993 ABC transporter signature motif; other site 498761007994 Walker B; other site 498761007995 D-loop; other site 498761007996 H-loop/switch region; other site 498761007997 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 498761007998 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 498761007999 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 498761008000 PDGLE domain; Region: PDGLE; pfam13190 498761008001 Restriction endonuclease [Defense mechanisms]; Region: COG3587 498761008002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761008003 ATP binding site [chemical binding]; other site 498761008004 putative Mg++ binding site [ion binding]; other site 498761008005 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 498761008006 DNA methylase; Region: N6_N4_Mtase; pfam01555 498761008007 DNA methylase; Region: N6_N4_Mtase; cl17433 498761008008 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 498761008009 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 498761008010 putative active site [active] 498761008011 catalytic site [active] 498761008012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498761008013 ATP binding site [chemical binding]; other site 498761008014 putative Mg++ binding site [ion binding]; other site 498761008015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498761008016 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 498761008017 nucleotide binding region [chemical binding]; other site 498761008018 ATP-binding site [chemical binding]; other site 498761008019 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 498761008020 active site 498761008021 NTP binding site [chemical binding]; other site 498761008022 metal binding triad [ion binding]; metal-binding site 498761008023 antibiotic binding site [chemical binding]; other site 498761008024 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761008025 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761008026 putative NTP binding site [chemical binding]; other site 498761008027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 498761008028 Predicted integral membrane protein [Function unknown]; Region: COG5658 498761008029 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 498761008030 SdpI/YhfL protein family; Region: SdpI; pfam13630 498761008031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498761008032 dimerization interface [polypeptide binding]; other site 498761008033 putative DNA binding site [nucleotide binding]; other site 498761008034 putative Zn2+ binding site [ion binding]; other site 498761008035 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 498761008036 L-lactate permease; Region: Lactate_perm; cl00701 498761008037 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 498761008038 FMN binding site [chemical binding]; other site 498761008039 dimer interface [polypeptide binding]; other site 498761008040 Sugar fermentation stimulation protein; Region: SfsA; cl00647 498761008041 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 498761008042 GIY-YIG motif/motif A; other site 498761008043 putative active site [active] 498761008044 putative metal binding site [ion binding]; other site 498761008045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761008046 dimer interface [polypeptide binding]; other site 498761008047 putative CheW interface [polypeptide binding]; other site 498761008048 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 498761008049 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 498761008050 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 498761008051 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 498761008052 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 498761008053 GatB domain; Region: GatB_Yqey; smart00845 498761008054 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 498761008055 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 498761008056 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 498761008057 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 498761008058 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 498761008059 nucleotide binding pocket [chemical binding]; other site 498761008060 K-X-D-G motif; other site 498761008061 catalytic site [active] 498761008062 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 498761008063 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 498761008064 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 498761008065 Dimer interface [polypeptide binding]; other site 498761008066 BRCT sequence motif; other site 498761008067 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 498761008068 Part of AAA domain; Region: AAA_19; pfam13245 498761008069 Family description; Region: UvrD_C_2; pfam13538 498761008070 Beta propeller domain; Region: Beta_propel; pfam09826 498761008071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498761008072 putative substrate translocation pore; other site 498761008073 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 498761008074 DNA methylase; Region: N6_N4_Mtase; cl17433 498761008075 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 498761008076 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 498761008077 Nucleoside recognition; Region: Gate; pfam07670 498761008078 Nucleoside recognition; Region: Gate; pfam07670 498761008079 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 498761008080 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 498761008081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 498761008082 metal binding site [ion binding]; metal-binding site 498761008083 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 498761008084 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 498761008085 substrate binding site [chemical binding]; other site 498761008086 glutamase interaction surface [polypeptide binding]; other site 498761008087 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 498761008088 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 498761008089 catalytic residues [active] 498761008090 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 498761008091 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 498761008092 putative active site [active] 498761008093 oxyanion strand; other site 498761008094 catalytic triad [active] 498761008095 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 498761008096 putative active site pocket [active] 498761008097 4-fold oligomerization interface [polypeptide binding]; other site 498761008098 metal binding residues [ion binding]; metal-binding site 498761008099 3-fold/trimer interface [polypeptide binding]; other site 498761008100 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 498761008101 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498761008102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761008103 homodimer interface [polypeptide binding]; other site 498761008104 catalytic residue [active] 498761008105 histidinol dehydrogenase; Region: hisD; TIGR00069 498761008106 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 498761008107 NAD binding site [chemical binding]; other site 498761008108 dimerization interface [polypeptide binding]; other site 498761008109 product binding site; other site 498761008110 substrate binding site [chemical binding]; other site 498761008111 zinc binding site [ion binding]; other site 498761008112 catalytic residues [active] 498761008113 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 498761008114 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 498761008115 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 498761008116 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 498761008117 dimer interface [polypeptide binding]; other site 498761008118 motif 1; other site 498761008119 active site 498761008120 motif 2; other site 498761008121 motif 3; other site 498761008122 Trp repressor protein; Region: Trp_repressor; cl17266 498761008123 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 498761008124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 498761008125 Probable transposase; Region: OrfB_IS605; pfam01385 498761008126 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498761008127 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 498761008128 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 498761008129 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498761008130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761008131 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 498761008132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498761008133 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 498761008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498761008135 catalytic residue [active] 498761008136 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 498761008137 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 498761008138 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 498761008139 YvrJ protein family; Region: YvrJ; pfam12841 498761008140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761008141 dimer interface [polypeptide binding]; other site 498761008142 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498761008143 putative CheW interface [polypeptide binding]; other site 498761008144 FeoA domain; Region: FeoA; pfam04023 498761008145 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 498761008146 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498761008147 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498761008148 G1 box; other site 498761008149 GTP/Mg2+ binding site [chemical binding]; other site 498761008150 Switch I region; other site 498761008151 G2 box; other site 498761008152 G3 box; other site 498761008153 Switch II region; other site 498761008154 G4 box; other site 498761008155 G5 box; other site 498761008156 Nucleoside recognition; Region: Gate; pfam07670 498761008157 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 498761008158 Nucleoside recognition; Region: Gate; pfam07670 498761008159 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 498761008160 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 498761008161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498761008162 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 498761008163 Transposase domain (DUF772); Region: DUF772; pfam05598 498761008164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761008165 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 498761008166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 498761008167 HsdM N-terminal domain; Region: HsdM_N; pfam12161 498761008168 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 498761008169 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498761008170 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 498761008171 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 498761008172 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498761008173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498761008174 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 498761008175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498761008176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498761008177 putative substrate translocation pore; other site 498761008178 PAS domain S-box; Region: sensory_box; TIGR00229 498761008179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498761008180 heme pocket [chemical binding]; other site 498761008181 putative active site [active] 498761008182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498761008183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498761008184 metal binding site [ion binding]; metal-binding site 498761008185 active site 498761008186 I-site; other site 498761008187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498761008188 Cache domain; Region: Cache_1; pfam02743 498761008189 HAMP domain; Region: HAMP; pfam00672 498761008190 dimerization interface [polypeptide binding]; other site 498761008191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761008192 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498761008193 dimer interface [polypeptide binding]; other site 498761008194 putative CheW interface [polypeptide binding]; other site 498761008195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498761008196 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498761008197 FtsX-like permease family; Region: FtsX; pfam02687 498761008198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498761008199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498761008200 Walker A/P-loop; other site 498761008201 ATP binding site [chemical binding]; other site 498761008202 Q-loop/lid; other site 498761008203 ABC transporter signature motif; other site 498761008204 Walker B; other site 498761008205 D-loop; other site 498761008206 H-loop/switch region; other site 498761008207 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 498761008208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 498761008209 HlyD family secretion protein; Region: HlyD_3; pfam13437 498761008210 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498761008211 Cation efflux family; Region: Cation_efflux; pfam01545 498761008212 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498761008213 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498761008214 putative active site [active] 498761008215 putative NTP binding site [chemical binding]; other site 498761008216 putative nucleic acid binding site [nucleotide binding]; other site 498761008217 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498761008218 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498761008219 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498761008220 active site 498761008221 metal binding site [ion binding]; metal-binding site 498761008222 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 498761008223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498761008224 dimer interface [polypeptide binding]; other site 498761008225 putative CheW interface [polypeptide binding]; other site 498761008226 FOG: CBS domain [General function prediction only]; Region: COG0517 498761008227 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 498761008228 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 498761008229 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 498761008230 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 498761008231 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 498761008232 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 498761008233 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 498761008234 purine monophosphate binding site [chemical binding]; other site 498761008235 dimer interface [polypeptide binding]; other site 498761008236 putative catalytic residues [active] 498761008237 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 498761008238 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 498761008239 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 498761008240 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 498761008241 active site 498761008242 substrate binding site [chemical binding]; other site 498761008243 cosubstrate binding site; other site 498761008244 catalytic site [active] 498761008245 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 498761008246 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 498761008247 dimerization interface [polypeptide binding]; other site 498761008248 putative ATP binding site [chemical binding]; other site 498761008249 amidophosphoribosyltransferase; Provisional; Region: PRK05793 498761008250 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 498761008251 active site 498761008252 tetramer interface [polypeptide binding]; other site 498761008253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498761008254 active site 498761008255 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 498761008256 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 498761008257 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 498761008258 ATP binding site [chemical binding]; other site 498761008259 active site 498761008260 substrate binding site [chemical binding]; other site 498761008261 adenylosuccinate lyase; Provisional; Region: PRK07492 498761008262 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 498761008263 tetramer interface [polypeptide binding]; other site 498761008264 active site 498761008265 AIR carboxylase; Region: AIRC; pfam00731 498761008266 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 498761008267 UbiA prenyltransferase family; Region: UbiA; pfam01040 498761008268 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 498761008269 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498761008270 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498761008271 Spore germination protein; Region: Spore_permease; cl17796 498761008272 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498761008273 S-layer homology domain; Region: SLH; pfam00395 498761008274 SpoVG; Region: SpoVG; cl00915