-- dump date 20140619_114822 -- class Genbank::misc_feature -- table misc_feature_note -- id note 757424000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 757424000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 757424000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424000004 Walker A motif; other site 757424000005 ATP binding site [chemical binding]; other site 757424000006 Walker B motif; other site 757424000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 757424000008 arginine finger; other site 757424000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 757424000010 DnaA box-binding interface [nucleotide binding]; other site 757424000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 757424000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 757424000013 putative DNA binding surface [nucleotide binding]; other site 757424000014 dimer interface [polypeptide binding]; other site 757424000015 beta-clamp/clamp loader binding surface; other site 757424000016 beta-clamp/translesion DNA polymerase binding surface; other site 757424000017 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 757424000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424000019 ATP binding site [chemical binding]; other site 757424000020 Mg2+ binding site [ion binding]; other site 757424000021 G-X-G motif; other site 757424000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 757424000023 anchoring element; other site 757424000024 dimer interface [polypeptide binding]; other site 757424000025 ATP binding site [chemical binding]; other site 757424000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 757424000027 active site 757424000028 putative metal-binding site [ion binding]; other site 757424000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 757424000030 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 757424000031 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 757424000032 putative active site [active] 757424000033 putative NTP binding site [chemical binding]; other site 757424000034 putative nucleic acid binding site [nucleotide binding]; other site 757424000035 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 757424000036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424000037 inhibitor-cofactor binding pocket; inhibition site 757424000038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424000039 catalytic residue [active] 757424000040 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 757424000041 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 757424000042 active site 757424000043 ATP binding site [chemical binding]; other site 757424000044 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 757424000045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424000046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424000047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424000048 metabolite-proton symporter; Region: 2A0106; TIGR00883 757424000049 putative substrate translocation pore; other site 757424000050 amidase; Provisional; Region: PRK07486 757424000051 Amidase; Region: Amidase; cl11426 757424000052 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424000053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424000054 dimerization interface [polypeptide binding]; other site 757424000055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424000056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424000057 metal binding site [ion binding]; metal-binding site 757424000058 active site 757424000059 I-site; other site 757424000060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424000061 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 757424000062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424000063 active site 757424000064 phosphorylation site [posttranslational modification] 757424000065 intermolecular recognition site; other site 757424000066 dimerization interface [polypeptide binding]; other site 757424000067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424000068 DNA binding site [nucleotide binding] 757424000069 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 757424000070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424000071 dimerization interface [polypeptide binding]; other site 757424000072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424000073 dimer interface [polypeptide binding]; other site 757424000074 phosphorylation site [posttranslational modification] 757424000075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424000076 ATP binding site [chemical binding]; other site 757424000077 Mg2+ binding site [ion binding]; other site 757424000078 G-X-G motif; other site 757424000079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424000080 non-specific DNA binding site [nucleotide binding]; other site 757424000081 salt bridge; other site 757424000082 sequence-specific DNA binding site [nucleotide binding]; other site 757424000083 Predicted membrane protein [Function unknown]; Region: COG2733 757424000084 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 757424000085 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 757424000086 active site 757424000087 acyl-activating enzyme (AAE) consensus motif; other site 757424000088 putative CoA binding site [chemical binding]; other site 757424000089 AMP binding site [chemical binding]; other site 757424000090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424000091 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424000092 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424000093 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424000094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 757424000095 PGAP1-like protein; Region: PGAP1; pfam07819 757424000096 PGAP1-like protein; Region: PGAP1; pfam07819 757424000097 Uncharacterized conserved protein [Function unknown]; Region: COG4104 757424000098 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424000099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424000100 dimerization interface [polypeptide binding]; other site 757424000101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424000102 dimer interface [polypeptide binding]; other site 757424000103 putative CheW interface [polypeptide binding]; other site 757424000104 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 757424000105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424000106 Walker A/P-loop; other site 757424000107 ATP binding site [chemical binding]; other site 757424000108 ABC transporter signature motif; other site 757424000109 Walker B; other site 757424000110 D-loop; other site 757424000111 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424000112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424000113 N-terminal plug; other site 757424000114 ligand-binding site [chemical binding]; other site 757424000115 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 757424000116 FecR protein; Region: FecR; pfam04773 757424000117 RNA polymerase sigma factor; Provisional; Region: PRK12528 757424000118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424000119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424000120 DNA binding residues [nucleotide binding] 757424000121 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 757424000122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424000123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424000124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424000125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424000127 putative effector binding pocket; other site 757424000128 dimerization interface [polypeptide binding]; other site 757424000129 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 757424000130 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 757424000131 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 757424000132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424000133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424000135 dimerization interface [polypeptide binding]; other site 757424000136 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 757424000137 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 757424000138 Mechanosensitive ion channel; Region: MS_channel; pfam00924 757424000139 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 757424000140 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 757424000141 catalytic triad [active] 757424000142 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424000144 putative substrate translocation pore; other site 757424000145 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 757424000146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000147 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 757424000148 putative dimerization interface [polypeptide binding]; other site 757424000149 putative substrate binding pocket [chemical binding]; other site 757424000150 FeoA domain; Region: FeoA; pfam04023 757424000151 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 757424000152 ferrous iron transporter FeoB; Region: feoB; TIGR00437 757424000153 G1 box; other site 757424000154 GTP/Mg2+ binding site [chemical binding]; other site 757424000155 Switch I region; other site 757424000156 G2 box; other site 757424000157 G3 box; other site 757424000158 Switch II region; other site 757424000159 G4 box; other site 757424000160 G5 box; other site 757424000161 Nucleoside recognition; Region: Gate; pfam07670 757424000162 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 757424000163 threonine dehydratase; Provisional; Region: PRK07334 757424000164 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 757424000165 tetramer interface [polypeptide binding]; other site 757424000166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424000167 catalytic residue [active] 757424000168 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 757424000169 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 757424000170 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 757424000171 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 757424000172 DNA binding site [nucleotide binding] 757424000173 active site 757424000174 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424000175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000176 putative PBP binding loops; other site 757424000177 dimer interface [polypeptide binding]; other site 757424000178 ABC-ATPase subunit interface; other site 757424000179 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424000180 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 757424000181 Walker A/P-loop; other site 757424000182 ATP binding site [chemical binding]; other site 757424000183 Q-loop/lid; other site 757424000184 ABC transporter signature motif; other site 757424000185 Walker B; other site 757424000186 D-loop; other site 757424000187 H-loop/switch region; other site 757424000188 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424000189 NMT1-like family; Region: NMT1_2; pfam13379 757424000190 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 757424000191 potassium uptake protein; Region: kup; TIGR00794 757424000192 ornithine cyclodeaminase; Validated; Region: PRK07589 757424000193 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 757424000194 Arginase family; Region: Arginase; cd09989 757424000195 active site 757424000196 Mn binding site [ion binding]; other site 757424000197 oligomer interface [polypeptide binding]; other site 757424000198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424000199 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424000200 substrate binding pocket [chemical binding]; other site 757424000201 membrane-bound complex binding site; other site 757424000202 hinge residues; other site 757424000203 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424000204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000205 dimer interface [polypeptide binding]; other site 757424000206 conserved gate region; other site 757424000207 putative PBP binding loops; other site 757424000208 ABC-ATPase subunit interface; other site 757424000209 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424000210 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424000211 Walker A/P-loop; other site 757424000212 ATP binding site [chemical binding]; other site 757424000213 Q-loop/lid; other site 757424000214 ABC transporter signature motif; other site 757424000215 Walker B; other site 757424000216 D-loop; other site 757424000217 H-loop/switch region; other site 757424000218 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 757424000219 EamA-like transporter family; Region: EamA; cl17759 757424000220 Putative methyltransferase; Region: Methyltransf_4; cl17290 757424000221 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 757424000222 Response regulator receiver domain; Region: Response_reg; pfam00072 757424000223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424000224 active site 757424000225 phosphorylation site [posttranslational modification] 757424000226 intermolecular recognition site; other site 757424000227 dimerization interface [polypeptide binding]; other site 757424000228 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 757424000229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424000230 dimerization interface [polypeptide binding]; other site 757424000231 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 757424000232 PAS domain; Region: PAS; smart00091 757424000233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424000234 dimer interface [polypeptide binding]; other site 757424000235 phosphorylation site [posttranslational modification] 757424000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424000237 ATP binding site [chemical binding]; other site 757424000238 Mg2+ binding site [ion binding]; other site 757424000239 G-X-G motif; other site 757424000240 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 757424000241 16S rRNA methyltransferase B; Provisional; Region: PRK10901 757424000242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424000243 S-adenosylmethionine binding site [chemical binding]; other site 757424000244 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 757424000245 Predicted membrane protein [Function unknown]; Region: COG1297 757424000246 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 757424000247 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 757424000248 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 757424000249 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424000250 putative acyl-acceptor binding pocket; other site 757424000251 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 757424000252 active site 757424000253 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 757424000254 active site 757424000255 catalytic residues [active] 757424000256 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 757424000257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424000258 Putative methyltransferase; Region: Methyltransf_20; pfam12147 757424000259 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 757424000260 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 757424000261 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 757424000262 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 757424000263 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 757424000264 Membrane fusogenic activity; Region: BMFP; pfam04380 757424000265 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 757424000266 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 757424000267 Nitrogen regulatory protein P-II; Region: P-II; smart00938 757424000268 ammonium transporter; Provisional; Region: PRK10666 757424000269 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 757424000270 Glutamate-cysteine ligase; Region: GshA; pfam08886 757424000271 glutathione synthetase; Provisional; Region: PRK05246 757424000272 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 757424000273 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 757424000274 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 757424000275 active pocket/dimerization site; other site 757424000276 active site 757424000277 phosphorylation site [posttranslational modification] 757424000278 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 757424000279 dimerization domain swap beta strand [polypeptide binding]; other site 757424000280 regulatory protein interface [polypeptide binding]; other site 757424000281 active site 757424000282 regulatory phosphorylation site [posttranslational modification]; other site 757424000283 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 757424000284 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 757424000285 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 757424000286 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 757424000287 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 757424000288 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 757424000289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424000290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424000291 S-adenosylmethionine binding site [chemical binding]; other site 757424000292 muropeptide transporter; Reviewed; Region: ampG; PRK11902 757424000293 AmpG-like permease; Region: 2A0125; TIGR00901 757424000294 elongation factor Tu; Reviewed; Region: PRK00049 757424000295 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 757424000296 G1 box; other site 757424000297 GEF interaction site [polypeptide binding]; other site 757424000298 GTP/Mg2+ binding site [chemical binding]; other site 757424000299 Switch I region; other site 757424000300 G2 box; other site 757424000301 G3 box; other site 757424000302 Switch II region; other site 757424000303 G4 box; other site 757424000304 G5 box; other site 757424000305 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 757424000306 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 757424000307 Antibiotic Binding Site [chemical binding]; other site 757424000308 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 757424000309 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 757424000310 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 757424000311 putative homodimer interface [polypeptide binding]; other site 757424000312 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 757424000313 heterodimer interface [polypeptide binding]; other site 757424000314 homodimer interface [polypeptide binding]; other site 757424000315 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 757424000316 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 757424000317 23S rRNA interface [nucleotide binding]; other site 757424000318 L7/L12 interface [polypeptide binding]; other site 757424000319 putative thiostrepton binding site; other site 757424000320 L25 interface [polypeptide binding]; other site 757424000321 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 757424000322 mRNA/rRNA interface [nucleotide binding]; other site 757424000323 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 757424000324 23S rRNA interface [nucleotide binding]; other site 757424000325 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 757424000326 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 757424000327 core dimer interface [polypeptide binding]; other site 757424000328 peripheral dimer interface [polypeptide binding]; other site 757424000329 L10 interface [polypeptide binding]; other site 757424000330 L11 interface [polypeptide binding]; other site 757424000331 putative EF-Tu interaction site [polypeptide binding]; other site 757424000332 putative EF-G interaction site [polypeptide binding]; other site 757424000333 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 757424000334 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 757424000335 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 757424000336 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 757424000337 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 757424000338 RPB12 interaction site [polypeptide binding]; other site 757424000339 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 757424000340 RPB3 interaction site [polypeptide binding]; other site 757424000341 RPB1 interaction site [polypeptide binding]; other site 757424000342 RPB11 interaction site [polypeptide binding]; other site 757424000343 RPB10 interaction site [polypeptide binding]; other site 757424000344 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 757424000345 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 757424000346 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 757424000347 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 757424000348 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 757424000349 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 757424000350 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 757424000351 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 757424000352 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 757424000353 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 757424000354 DNA binding site [nucleotide binding] 757424000355 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 757424000356 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 757424000357 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424000358 N-terminal plug; other site 757424000359 ligand-binding site [chemical binding]; other site 757424000360 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 757424000361 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 757424000362 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 757424000363 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 757424000364 S17 interaction site [polypeptide binding]; other site 757424000365 S8 interaction site; other site 757424000366 16S rRNA interaction site [nucleotide binding]; other site 757424000367 streptomycin interaction site [chemical binding]; other site 757424000368 23S rRNA interaction site [nucleotide binding]; other site 757424000369 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 757424000370 30S ribosomal protein S7; Validated; Region: PRK05302 757424000371 elongation factor G; Reviewed; Region: PRK00007 757424000372 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 757424000373 G1 box; other site 757424000374 putative GEF interaction site [polypeptide binding]; other site 757424000375 GTP/Mg2+ binding site [chemical binding]; other site 757424000376 Switch I region; other site 757424000377 G2 box; other site 757424000378 G3 box; other site 757424000379 Switch II region; other site 757424000380 G4 box; other site 757424000381 G5 box; other site 757424000382 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 757424000383 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 757424000384 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 757424000385 elongation factor Tu; Reviewed; Region: PRK00049 757424000386 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 757424000387 G1 box; other site 757424000388 GEF interaction site [polypeptide binding]; other site 757424000389 GTP/Mg2+ binding site [chemical binding]; other site 757424000390 Switch I region; other site 757424000391 G2 box; other site 757424000392 G3 box; other site 757424000393 Switch II region; other site 757424000394 G4 box; other site 757424000395 G5 box; other site 757424000396 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 757424000397 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 757424000398 Antibiotic Binding Site [chemical binding]; other site 757424000399 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 757424000400 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 757424000401 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 757424000402 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 757424000403 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 757424000404 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 757424000405 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 757424000406 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 757424000407 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 757424000408 putative translocon binding site; other site 757424000409 protein-rRNA interface [nucleotide binding]; other site 757424000410 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 757424000411 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 757424000412 G-X-X-G motif; other site 757424000413 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 757424000414 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 757424000415 23S rRNA interface [nucleotide binding]; other site 757424000416 5S rRNA interface [nucleotide binding]; other site 757424000417 putative antibiotic binding site [chemical binding]; other site 757424000418 L25 interface [polypeptide binding]; other site 757424000419 L27 interface [polypeptide binding]; other site 757424000420 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 757424000421 L23 interface [polypeptide binding]; other site 757424000422 signal recognition particle (SRP54) interaction site; other site 757424000423 trigger factor interaction site; other site 757424000424 23S rRNA interface [nucleotide binding]; other site 757424000425 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 757424000426 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 757424000427 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 757424000428 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 757424000429 RNA binding site [nucleotide binding]; other site 757424000430 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 757424000431 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 757424000432 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 757424000433 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 757424000434 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 757424000435 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 757424000436 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 757424000437 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 757424000438 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 757424000439 5S rRNA interface [nucleotide binding]; other site 757424000440 23S rRNA interface [nucleotide binding]; other site 757424000441 L5 interface [polypeptide binding]; other site 757424000442 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 757424000443 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 757424000444 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 757424000445 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 757424000446 23S rRNA binding site [nucleotide binding]; other site 757424000447 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 757424000448 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 757424000449 SecY translocase; Region: SecY; pfam00344 757424000450 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 757424000451 rRNA binding site [nucleotide binding]; other site 757424000452 predicted 30S ribosome binding site; other site 757424000453 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 757424000454 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 757424000455 30S ribosomal protein S13; Region: bact_S13; TIGR03631 757424000456 30S ribosomal protein S11; Validated; Region: PRK05309 757424000457 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 757424000458 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 757424000459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424000460 RNA binding surface [nucleotide binding]; other site 757424000461 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 757424000462 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 757424000463 alphaNTD homodimer interface [polypeptide binding]; other site 757424000464 alphaNTD - beta interaction site [polypeptide binding]; other site 757424000465 alphaNTD - beta' interaction site [polypeptide binding]; other site 757424000466 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 757424000467 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 757424000468 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 757424000469 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 757424000470 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 757424000471 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 757424000472 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 757424000473 DsbD alpha interface [polypeptide binding]; other site 757424000474 catalytic residues [active] 757424000475 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 757424000476 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 757424000477 dimer interface [polypeptide binding]; other site 757424000478 decamer (pentamer of dimers) interface [polypeptide binding]; other site 757424000479 catalytic triad [active] 757424000480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424000481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424000483 dimerization interface [polypeptide binding]; other site 757424000484 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 757424000485 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 757424000486 putative active site [active] 757424000487 metal binding site [ion binding]; metal-binding site 757424000488 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 757424000489 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 757424000490 dimer interface [polypeptide binding]; other site 757424000491 NADP binding site [chemical binding]; other site 757424000492 catalytic residues [active] 757424000493 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424000494 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 757424000495 putative ligand binding site [chemical binding]; other site 757424000496 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 757424000497 Uncharacterized conserved protein [Function unknown]; Region: COG2128 757424000498 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 757424000499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424000500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424000501 DNA binding residues [nucleotide binding] 757424000502 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 757424000503 dimer interface [polypeptide binding]; other site 757424000504 active site 757424000505 aspartate-rich active site metal binding site; other site 757424000506 allosteric magnesium binding site [ion binding]; other site 757424000507 Schiff base residues; other site 757424000508 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 757424000509 G1 box; other site 757424000510 GTP/Mg2+ binding site [chemical binding]; other site 757424000511 Switch I region; other site 757424000512 G2 box; other site 757424000513 G3 box; other site 757424000514 Switch II region; other site 757424000515 G4 box; other site 757424000516 G5 box; other site 757424000517 Cytochrome c553 [Energy production and conversion]; Region: COG2863 757424000518 Cytochrome c; Region: Cytochrom_C; cl11414 757424000519 ResB-like family; Region: ResB; pfam05140 757424000520 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 757424000521 ResB-like family; Region: ResB; pfam05140 757424000522 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 757424000523 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 757424000524 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 757424000525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424000526 motif II; other site 757424000527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 757424000528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 757424000529 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 757424000530 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 757424000531 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 757424000532 Bacterial SH3 domain; Region: SH3_4; pfam06347 757424000533 Bacterial SH3 domain; Region: SH3_3; cl17532 757424000534 preprotein translocase subunit SecB; Validated; Region: PRK05751 757424000535 SecA binding site; other site 757424000536 Preprotein binding site; other site 757424000537 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 757424000538 GSH binding site [chemical binding]; other site 757424000539 catalytic residues [active] 757424000540 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 757424000541 active site residue [active] 757424000542 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 757424000543 catalytic core [active] 757424000544 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 757424000545 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424000546 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 757424000547 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 757424000548 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 757424000549 protein binding site [polypeptide binding]; other site 757424000550 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 757424000551 Catalytic dyad [active] 757424000552 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 757424000553 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 757424000554 ATP binding site [chemical binding]; other site 757424000555 substrate interface [chemical binding]; other site 757424000556 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 757424000557 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 757424000558 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 757424000559 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 757424000560 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 757424000561 Cupin; Region: Cupin_6; pfam12852 757424000562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424000563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424000564 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 757424000565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424000566 putative DNA binding site [nucleotide binding]; other site 757424000567 putative Zn2+ binding site [ion binding]; other site 757424000568 AsnC family; Region: AsnC_trans_reg; pfam01037 757424000569 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424000570 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 757424000571 dimerization interface [polypeptide binding]; other site 757424000572 ligand binding site [chemical binding]; other site 757424000573 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 757424000574 Proline racemase; Region: Pro_racemase; pfam05544 757424000575 ornithine cyclodeaminase; Validated; Region: PRK07340 757424000576 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 757424000577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424000578 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424000579 TM-ABC transporter signature motif; other site 757424000580 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424000581 TM-ABC transporter signature motif; other site 757424000582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424000583 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424000584 Walker A/P-loop; other site 757424000585 ATP binding site [chemical binding]; other site 757424000586 Q-loop/lid; other site 757424000587 ABC transporter signature motif; other site 757424000588 Walker B; other site 757424000589 D-loop; other site 757424000590 H-loop/switch region; other site 757424000591 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424000592 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424000593 Walker A/P-loop; other site 757424000594 ATP binding site [chemical binding]; other site 757424000595 Q-loop/lid; other site 757424000596 ABC transporter signature motif; other site 757424000597 Walker B; other site 757424000598 D-loop; other site 757424000599 H-loop/switch region; other site 757424000600 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 757424000601 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 757424000602 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 757424000603 Glutamate binding site [chemical binding]; other site 757424000604 NAD binding site [chemical binding]; other site 757424000605 catalytic residues [active] 757424000606 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 757424000607 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 757424000608 active site 757424000609 HslU subunit interaction site [polypeptide binding]; other site 757424000610 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 757424000611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424000612 Walker A motif; other site 757424000613 ATP binding site [chemical binding]; other site 757424000614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424000615 Walker B motif; other site 757424000616 arginine finger; other site 757424000617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 757424000618 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424000619 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424000620 eyelet of channel; other site 757424000621 trimer interface [polypeptide binding]; other site 757424000622 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424000623 Sel1 repeat; Region: Sel1; pfam08238 757424000624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424000625 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424000626 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 757424000627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424000628 N-terminal plug; other site 757424000629 ligand-binding site [chemical binding]; other site 757424000630 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 757424000631 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 757424000632 putative iron binding site [ion binding]; other site 757424000633 diaminopimelate decarboxylase; Region: lysA; TIGR01048 757424000634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 757424000635 active site 757424000636 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424000637 substrate binding site [chemical binding]; other site 757424000638 catalytic residues [active] 757424000639 dimer interface [polypeptide binding]; other site 757424000640 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 757424000641 Na binding site [ion binding]; other site 757424000642 putative glycosylation site [posttranslational modification]; other site 757424000643 putative glycosylation site [posttranslational modification]; other site 757424000644 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 757424000645 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 757424000646 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 757424000647 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 757424000648 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 757424000649 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 757424000650 active site 757424000651 homotetramer interface [polypeptide binding]; other site 757424000652 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 757424000653 Uncharacterized conserved protein [Function unknown]; Region: COG2928 757424000654 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 757424000655 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 757424000656 dimer interface [polypeptide binding]; other site 757424000657 anticodon binding site; other site 757424000658 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 757424000659 homodimer interface [polypeptide binding]; other site 757424000660 motif 1; other site 757424000661 active site 757424000662 motif 2; other site 757424000663 GAD domain; Region: GAD; pfam02938 757424000664 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 757424000665 motif 3; other site 757424000666 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 757424000667 Baseplate J-like protein; Region: Baseplate_J; cl01294 757424000668 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 757424000669 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 757424000670 Baseplate J-like protein; Region: Baseplate_J; cl01294 757424000671 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 757424000672 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 757424000673 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 757424000674 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 757424000675 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 757424000676 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 757424000677 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 757424000678 Phage tail tube protein FII; Region: Phage_tube; pfam04985 757424000679 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 757424000680 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 757424000681 Predicted transcriptional regulator [Transcription]; Region: COG2932 757424000682 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 757424000683 Catalytic site [active] 757424000684 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 757424000685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 757424000686 dimerization interface [polypeptide binding]; other site 757424000687 putative Zn2+ binding site [ion binding]; other site 757424000688 putative DNA binding site [nucleotide binding]; other site 757424000689 Integrase core domain; Region: rve; pfam00665 757424000690 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 757424000691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424000692 Walker A/P-loop; other site 757424000693 ATP binding site [chemical binding]; other site 757424000694 Mor transcription activator family; Region: Mor; cl02360 757424000695 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 757424000696 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 757424000697 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 757424000698 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 757424000699 citrate-proton symporter; Provisional; Region: PRK15075 757424000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424000701 putative substrate translocation pore; other site 757424000702 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 757424000703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424000704 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 757424000705 active site 757424000706 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424000707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000708 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424000709 dimerization interface [polypeptide binding]; other site 757424000710 substrate binding pocket [chemical binding]; other site 757424000711 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 757424000712 nudix motif; other site 757424000713 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 757424000714 putative catalytic site [active] 757424000715 putative metal binding site [ion binding]; other site 757424000716 putative phosphate binding site [ion binding]; other site 757424000717 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 757424000718 PLD-like domain; Region: PLDc_2; pfam13091 757424000719 putative active site [active] 757424000720 catalytic site [active] 757424000721 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 757424000722 PLD-like domain; Region: PLDc_2; pfam13091 757424000723 putative active site [active] 757424000724 catalytic site [active] 757424000725 putative acyltransferase; Provisional; Region: PRK05790 757424000726 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424000727 dimer interface [polypeptide binding]; other site 757424000728 active site 757424000729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424000730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424000731 substrate binding pocket [chemical binding]; other site 757424000732 membrane-bound complex binding site; other site 757424000733 hinge residues; other site 757424000734 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424000735 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424000736 Walker A/P-loop; other site 757424000737 ATP binding site [chemical binding]; other site 757424000738 Q-loop/lid; other site 757424000739 ABC transporter signature motif; other site 757424000740 Walker B; other site 757424000741 D-loop; other site 757424000742 H-loop/switch region; other site 757424000743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000744 dimer interface [polypeptide binding]; other site 757424000745 conserved gate region; other site 757424000746 putative PBP binding loops; other site 757424000747 ABC-ATPase subunit interface; other site 757424000748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000749 dimer interface [polypeptide binding]; other site 757424000750 conserved gate region; other site 757424000751 putative PBP binding loops; other site 757424000752 ABC-ATPase subunit interface; other site 757424000753 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 757424000754 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 757424000755 active site 757424000756 substrate binding site [chemical binding]; other site 757424000757 FMN binding site [chemical binding]; other site 757424000758 putative catalytic residues [active] 757424000759 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424000760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424000761 DNA-binding site [nucleotide binding]; DNA binding site 757424000762 FCD domain; Region: FCD; pfam07729 757424000763 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424000764 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 757424000765 putative active site [active] 757424000766 catalytic site [active] 757424000767 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424000768 Sel1-like repeats; Region: SEL1; smart00671 757424000769 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 757424000770 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 757424000771 putative active site [active] 757424000772 catalytic site [active] 757424000773 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 757424000774 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 757424000775 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 757424000776 putative active site [active] 757424000777 catalytic site [active] 757424000778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424000779 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424000780 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424000781 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424000782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 757424000783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424000784 RNA binding surface [nucleotide binding]; other site 757424000785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424000786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424000787 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 757424000788 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 757424000789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424000790 active site 757424000791 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 757424000792 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 757424000793 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 757424000794 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 757424000795 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 757424000796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424000797 substrate binding site [chemical binding]; other site 757424000798 oxyanion hole (OAH) forming residues; other site 757424000799 trimer interface [polypeptide binding]; other site 757424000800 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 757424000801 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424000802 dimer interface [polypeptide binding]; other site 757424000803 active site 757424000804 enoyl-CoA hydratase; Provisional; Region: PRK06688 757424000805 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424000806 substrate binding site [chemical binding]; other site 757424000807 oxyanion hole (OAH) forming residues; other site 757424000808 trimer interface [polypeptide binding]; other site 757424000809 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424000810 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 757424000811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424000812 dimerization interface [polypeptide binding]; other site 757424000813 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424000814 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424000815 dimer interface [polypeptide binding]; other site 757424000816 putative CheW interface [polypeptide binding]; other site 757424000817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424000818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424000819 metal binding site [ion binding]; metal-binding site 757424000820 active site 757424000821 I-site; other site 757424000822 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424000823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424000824 metal binding site [ion binding]; metal-binding site 757424000825 active site 757424000826 I-site; other site 757424000827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424000828 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 757424000829 acetate kinase; Provisional; Region: PRK07058 757424000830 propionate/acetate kinase; Provisional; Region: PRK12379 757424000831 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 757424000832 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 757424000833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424000834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424000835 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424000836 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424000837 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 757424000838 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424000839 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000841 dimer interface [polypeptide binding]; other site 757424000842 conserved gate region; other site 757424000843 putative PBP binding loops; other site 757424000844 ABC-ATPase subunit interface; other site 757424000845 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 757424000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424000847 dimer interface [polypeptide binding]; other site 757424000848 conserved gate region; other site 757424000849 putative PBP binding loops; other site 757424000850 ABC-ATPase subunit interface; other site 757424000851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424000852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424000853 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 757424000854 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 757424000855 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 757424000856 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 757424000857 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 757424000858 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 757424000859 Walker A/P-loop; other site 757424000860 ATP binding site [chemical binding]; other site 757424000861 Q-loop/lid; other site 757424000862 ABC transporter signature motif; other site 757424000863 Walker B; other site 757424000864 D-loop; other site 757424000865 H-loop/switch region; other site 757424000866 TOBE domain; Region: TOBE_2; pfam08402 757424000867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424000868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424000869 DNA binding site [nucleotide binding] 757424000870 domain linker motif; other site 757424000871 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 757424000872 dimerization interface [polypeptide binding]; other site 757424000873 ligand binding site [chemical binding]; other site 757424000874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424000875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424000876 major facilitator superfamily transporter; Provisional; Region: PRK05122 757424000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424000878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424000879 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424000880 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424000881 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 757424000883 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 757424000884 Uncharacterized conserved protein [Function unknown]; Region: COG4104 757424000885 GAF domain; Region: GAF; pfam01590 757424000886 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424000887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424000888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424000889 metal binding site [ion binding]; metal-binding site 757424000890 active site 757424000891 I-site; other site 757424000892 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 757424000893 putative substrate binding pocket [chemical binding]; other site 757424000894 trimer interface [polypeptide binding]; other site 757424000895 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 757424000896 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 757424000897 tetramer interface [polypeptide binding]; other site 757424000898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424000899 catalytic residue [active] 757424000900 YheO-like PAS domain; Region: PAS_6; pfam08348 757424000901 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 757424000902 DNA-binding interface [nucleotide binding]; DNA binding site 757424000903 palmytilated EEV membrane glycoprotein; Provisional; Region: PHA03003 757424000904 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 757424000905 putative active site [active] 757424000906 putative catalytic site [active] 757424000907 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 757424000908 putative active site [active] 757424000909 putative catalytic site [active] 757424000910 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 757424000911 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 757424000912 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424000913 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 757424000914 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 757424000915 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424000916 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 757424000917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 757424000918 CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611 757424000919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424000920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000921 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424000922 putative effector binding pocket; other site 757424000923 dimerization interface [polypeptide binding]; other site 757424000924 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 757424000925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424000926 NAD(P) binding site [chemical binding]; other site 757424000927 active site 757424000928 putative chaperone; Provisional; Region: PRK11678 757424000929 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 757424000930 nucleotide binding site [chemical binding]; other site 757424000931 putative NEF/HSP70 interaction site [polypeptide binding]; other site 757424000932 SBD interface [polypeptide binding]; other site 757424000933 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424000934 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424000935 active site 757424000936 catalytic tetrad [active] 757424000937 CHASE2 domain; Region: CHASE2; pfam05226 757424000938 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 757424000939 cyclase homology domain; Region: CHD; cd07302 757424000940 nucleotidyl binding site; other site 757424000941 metal binding site [ion binding]; metal-binding site 757424000942 dimer interface [polypeptide binding]; other site 757424000943 B12 binding domain; Region: B12-binding; pfam02310 757424000944 B12 binding site [chemical binding]; other site 757424000945 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 757424000946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424000947 FeS/SAM binding site; other site 757424000948 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 757424000949 TPP-binding site [chemical binding]; other site 757424000950 dimer interface [polypeptide binding]; other site 757424000951 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 757424000952 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 757424000953 PYR/PP interface [polypeptide binding]; other site 757424000954 dimer interface [polypeptide binding]; other site 757424000955 TPP binding site [chemical binding]; other site 757424000956 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 757424000957 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424000958 extended (e) SDRs; Region: SDR_e; cd08946 757424000959 NAD(P) binding site [chemical binding]; other site 757424000960 active site 757424000961 substrate binding site [chemical binding]; other site 757424000962 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 757424000963 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 757424000964 Surface antigen; Region: Bac_surface_Ag; pfam01103 757424000965 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 757424000966 FecR protein; Region: FecR; pfam04773 757424000967 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 757424000968 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424000969 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 757424000970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424000971 Zn2+ binding site [ion binding]; other site 757424000972 Mg2+ binding site [ion binding]; other site 757424000973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424000974 Predicted periplasmic protein [Function unknown]; Region: COG3904 757424000975 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 757424000976 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 757424000977 Sulfate transporter family; Region: Sulfate_transp; pfam00916 757424000978 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 757424000979 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 757424000980 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424000981 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 757424000982 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424000983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424000984 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424000985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 757424000986 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 757424000987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424000988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424000989 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 757424000990 putative effector binding pocket; other site 757424000991 putative dimerization interface [polypeptide binding]; other site 757424000992 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 757424000993 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424000994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424000995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424000996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424000997 active site 757424000998 catalytic tetrad [active] 757424000999 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 757424001000 MarR family; Region: MarR_2; pfam12802 757424001001 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 757424001002 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 757424001003 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424001004 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 757424001005 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424001006 substrate binding site [chemical binding]; other site 757424001007 oxyanion hole (OAH) forming residues; other site 757424001008 trimer interface [polypeptide binding]; other site 757424001009 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 757424001010 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 757424001011 IHF dimer interface [polypeptide binding]; other site 757424001012 IHF - DNA interface [nucleotide binding]; other site 757424001013 cell division protein MraZ; Reviewed; Region: PRK00326 757424001014 MraZ protein; Region: MraZ; pfam02381 757424001015 MraZ protein; Region: MraZ; pfam02381 757424001016 MraW methylase family; Region: Methyltransf_5; cl17771 757424001017 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 757424001018 Cell division protein FtsL; Region: FtsL; pfam04999 757424001019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 757424001020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 757424001021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 757424001022 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 757424001023 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 757424001024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424001026 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 757424001027 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 757424001028 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001029 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424001030 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 757424001031 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 757424001032 Mg++ binding site [ion binding]; other site 757424001033 putative catalytic motif [active] 757424001034 putative substrate binding site [chemical binding]; other site 757424001035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001036 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 757424001037 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001038 cell division protein FtsW; Region: ftsW; TIGR02614 757424001039 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 757424001040 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 757424001041 active site 757424001042 homodimer interface [polypeptide binding]; other site 757424001043 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 757424001044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 757424001045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424001047 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 757424001048 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 757424001049 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 757424001050 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424001051 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 757424001052 Cell division protein FtsQ; Region: FtsQ; pfam03799 757424001053 cell division protein FtsA; Region: ftsA; TIGR01174 757424001054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 757424001055 nucleotide binding site [chemical binding]; other site 757424001056 Cell division protein FtsA; Region: FtsA; pfam14450 757424001057 cell division protein FtsZ; Validated; Region: PRK09330 757424001058 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 757424001059 nucleotide binding site [chemical binding]; other site 757424001060 SulA interaction site; other site 757424001061 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 757424001062 catalytic triad [active] 757424001063 dimer interface [polypeptide binding]; other site 757424001064 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 757424001065 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 757424001066 Protein of unknown function (DUF721); Region: DUF721; pfam05258 757424001067 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 757424001068 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424001069 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 757424001070 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 757424001071 SEC-C motif; Region: SEC-C; pfam02810 757424001072 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 757424001073 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 757424001074 active site 757424001075 catalytic triad [active] 757424001076 oxyanion hole [active] 757424001077 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 757424001078 heterotetramer interface [polypeptide binding]; other site 757424001079 active site pocket [active] 757424001080 cleavage site 757424001081 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 757424001082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424001083 Walker A motif; other site 757424001084 ATP binding site [chemical binding]; other site 757424001085 Walker B motif; other site 757424001086 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 757424001087 active site 757424001088 8-oxo-dGMP binding site [chemical binding]; other site 757424001089 nudix motif; other site 757424001090 metal binding site [ion binding]; metal-binding site 757424001091 Domain of unknown function (DUF329); Region: DUF329; pfam03884 757424001092 hypothetical protein; Provisional; Region: PRK05287 757424001093 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 757424001094 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 757424001095 CoA-binding site [chemical binding]; other site 757424001096 ATP-binding [chemical binding]; other site 757424001097 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 757424001098 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 757424001099 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 757424001100 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 757424001101 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 757424001102 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 757424001103 Type II/IV secretion system protein; Region: T2SE; pfam00437 757424001104 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 757424001105 Walker A motif; other site 757424001106 ATP binding site [chemical binding]; other site 757424001107 Walker B motif; other site 757424001108 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 757424001109 Domain of unknown function DUF21; Region: DUF21; pfam01595 757424001110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 757424001111 Transporter associated domain; Region: CorC_HlyC; smart01091 757424001112 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 757424001113 rRNA binding site [nucleotide binding]; other site 757424001114 predicted 30S ribosome binding site; other site 757424001115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 757424001116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 757424001117 substrate binding pocket [chemical binding]; other site 757424001118 chain length determination region; other site 757424001119 substrate-Mg2+ binding site; other site 757424001120 catalytic residues [active] 757424001121 aspartate-rich region 1; other site 757424001122 active site lid residues [active] 757424001123 aspartate-rich region 2; other site 757424001124 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 757424001125 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 757424001126 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 757424001127 GTPase CgtA; Reviewed; Region: obgE; PRK12299 757424001128 GTP1/OBG; Region: GTP1_OBG; pfam01018 757424001129 Obg GTPase; Region: Obg; cd01898 757424001130 G1 box; other site 757424001131 GTP/Mg2+ binding site [chemical binding]; other site 757424001132 Switch I region; other site 757424001133 G2 box; other site 757424001134 G3 box; other site 757424001135 Switch II region; other site 757424001136 G4 box; other site 757424001137 G5 box; other site 757424001138 gamma-glutamyl kinase; Provisional; Region: PRK05429 757424001139 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 757424001140 nucleotide binding site [chemical binding]; other site 757424001141 homotetrameric interface [polypeptide binding]; other site 757424001142 putative phosphate binding site [ion binding]; other site 757424001143 putative allosteric binding site; other site 757424001144 PUA domain; Region: PUA; pfam01472 757424001145 CNP1-like family; Region: CNP1; pfam08750 757424001146 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 757424001147 putative active site [active] 757424001148 Ap4A binding site [chemical binding]; other site 757424001149 nudix motif; other site 757424001150 putative metal binding site [ion binding]; other site 757424001151 prolyl-tRNA synthetase; Provisional; Region: PRK09194 757424001152 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 757424001153 dimer interface [polypeptide binding]; other site 757424001154 motif 1; other site 757424001155 active site 757424001156 motif 2; other site 757424001157 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 757424001158 putative deacylase active site [active] 757424001159 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 757424001160 active site 757424001161 motif 3; other site 757424001162 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 757424001163 anticodon binding site; other site 757424001164 SWIB/MDM2 domain; Region: SWIB; pfam02201 757424001165 signal recognition particle protein; Provisional; Region: PRK10867 757424001166 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 757424001167 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 757424001168 P loop; other site 757424001169 GTP binding site [chemical binding]; other site 757424001170 Signal peptide binding domain; Region: SRP_SPB; pfam02978 757424001171 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424001172 NMT1/THI5 like; Region: NMT1; pfam09084 757424001173 substrate binding pocket [chemical binding]; other site 757424001174 membrane-bound complex binding site; other site 757424001175 hinge residues; other site 757424001176 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424001177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001178 putative PBP binding loops; other site 757424001179 dimer interface [polypeptide binding]; other site 757424001180 ABC-ATPase subunit interface; other site 757424001181 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424001182 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424001183 Walker A/P-loop; other site 757424001184 ATP binding site [chemical binding]; other site 757424001185 Q-loop/lid; other site 757424001186 ABC transporter signature motif; other site 757424001187 Walker B; other site 757424001188 D-loop; other site 757424001189 H-loop/switch region; other site 757424001190 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 757424001191 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 757424001192 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 757424001193 amidase catalytic site [active] 757424001194 Zn binding residues [ion binding]; other site 757424001195 substrate binding site [chemical binding]; other site 757424001196 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 757424001197 ATP cone domain; Region: ATP-cone; pfam03477 757424001198 Class I ribonucleotide reductase; Region: RNR_I; cd01679 757424001199 active site 757424001200 dimer interface [polypeptide binding]; other site 757424001201 catalytic residues [active] 757424001202 effector binding site; other site 757424001203 R2 peptide binding site; other site 757424001204 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 757424001205 dimer interface [polypeptide binding]; other site 757424001206 putative radical transfer pathway; other site 757424001207 diiron center [ion binding]; other site 757424001208 tyrosyl radical; other site 757424001209 YGGT family; Region: YGGT; pfam02325 757424001210 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 757424001211 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 757424001212 catalytic triad [active] 757424001213 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424001214 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 757424001215 substrate binding site [chemical binding]; other site 757424001216 ATP binding site [chemical binding]; other site 757424001217 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 757424001218 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 757424001219 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 757424001220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424001221 S-adenosylmethionine binding site [chemical binding]; other site 757424001222 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 757424001223 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424001224 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424001225 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 757424001226 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 757424001227 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 757424001228 carboxyltransferase (CT) interaction site; other site 757424001229 biotinylation site [posttranslational modification]; other site 757424001230 Dehydroquinase class II; Region: DHquinase_II; pfam01220 757424001231 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 757424001232 active site 757424001233 trimer interface [polypeptide binding]; other site 757424001234 dimer interface [polypeptide binding]; other site 757424001235 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 757424001236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 757424001237 catalytic residues [active] 757424001238 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424001239 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424001240 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 757424001241 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 757424001242 dimerization interface [polypeptide binding]; other site 757424001243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424001244 dimer interface [polypeptide binding]; other site 757424001245 putative CheW interface [polypeptide binding]; other site 757424001246 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 757424001247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 757424001248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424001249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424001250 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 757424001251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424001252 Chorismate lyase; Region: Chor_lyase; cl01230 757424001253 RNB domain; Region: RNB; pfam00773 757424001254 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 757424001255 TonB C terminal; Region: TonB_2; pfam13103 757424001256 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 757424001257 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 757424001258 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 757424001259 NAD(P) binding site [chemical binding]; other site 757424001260 shikimate binding site; other site 757424001261 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 757424001262 Transglycosylase; Region: Transgly; cl17702 757424001263 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 757424001264 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 757424001265 Cl binding site [ion binding]; other site 757424001266 oligomer interface [polypeptide binding]; other site 757424001267 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 757424001268 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 757424001269 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424001270 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 757424001271 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 757424001272 active site 757424001273 HIGH motif; other site 757424001274 dimer interface [polypeptide binding]; other site 757424001275 KMSKS motif; other site 757424001276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424001277 RNA binding surface [nucleotide binding]; other site 757424001278 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 757424001279 putative active site [active] 757424001280 dimerization interface [polypeptide binding]; other site 757424001281 putative tRNAtyr binding site [nucleotide binding]; other site 757424001282 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 757424001283 substrate binding site [chemical binding]; other site 757424001284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 757424001285 catalytic core [active] 757424001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424001287 non-specific DNA binding site [nucleotide binding]; other site 757424001288 salt bridge; other site 757424001289 sequence-specific DNA binding site [nucleotide binding]; other site 757424001290 HipA N-terminal domain; Region: Couple_hipA; pfam13657 757424001291 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 757424001292 HipA-like N-terminal domain; Region: HipA_N; pfam07805 757424001293 HipA-like C-terminal domain; Region: HipA_C; pfam07804 757424001294 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 757424001295 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 757424001296 FMN binding site [chemical binding]; other site 757424001297 active site 757424001298 catalytic residues [active] 757424001299 substrate binding site [chemical binding]; other site 757424001300 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 757424001301 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 757424001302 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 757424001303 purine monophosphate binding site [chemical binding]; other site 757424001304 dimer interface [polypeptide binding]; other site 757424001305 putative catalytic residues [active] 757424001306 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 757424001307 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 757424001308 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 757424001309 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 757424001310 DNA binding residues [nucleotide binding] 757424001311 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 757424001312 Protein of unknown function, DUF393; Region: DUF393; pfam04134 757424001313 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 757424001314 active site 757424001315 putative DNA-binding cleft [nucleotide binding]; other site 757424001316 dimer interface [polypeptide binding]; other site 757424001317 Protein of unknown function (DUF808); Region: DUF808; pfam05661 757424001318 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 757424001319 RuvA N terminal domain; Region: RuvA_N; pfam01330 757424001320 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 757424001321 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 757424001322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424001323 Walker A motif; other site 757424001324 ATP binding site [chemical binding]; other site 757424001325 Walker B motif; other site 757424001326 arginine finger; other site 757424001327 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 757424001328 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 757424001329 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 757424001330 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 757424001331 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 757424001332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424001333 active site 757424001334 HIGH motif; other site 757424001335 nucleotide binding site [chemical binding]; other site 757424001336 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 757424001337 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 757424001338 active site 757424001339 KMSKS motif; other site 757424001340 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 757424001341 tRNA binding surface [nucleotide binding]; other site 757424001342 anticodon binding site; other site 757424001343 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 757424001344 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 757424001345 ThiC-associated domain; Region: ThiC-associated; pfam13667 757424001346 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 757424001347 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 757424001348 ThiS interaction site; other site 757424001349 putative active site [active] 757424001350 tetramer interface [polypeptide binding]; other site 757424001351 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 757424001352 dimer interface [polypeptide binding]; other site 757424001353 substrate binding site [chemical binding]; other site 757424001354 ATP binding site [chemical binding]; other site 757424001355 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 757424001356 thiamine phosphate binding site [chemical binding]; other site 757424001357 active site 757424001358 pyrophosphate binding site [ion binding]; other site 757424001359 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 757424001360 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 757424001361 dimerization interface [polypeptide binding]; other site 757424001362 DPS ferroxidase diiron center [ion binding]; other site 757424001363 ion pore; other site 757424001364 putative transporter; Provisional; Region: PRK12382 757424001365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001366 putative substrate translocation pore; other site 757424001367 Chorismate mutase type II; Region: CM_2; cl00693 757424001368 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 757424001369 Part of AAA domain; Region: AAA_19; pfam13245 757424001370 Family description; Region: UvrD_C_2; pfam13538 757424001371 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 757424001372 HSP70 interaction site [polypeptide binding]; other site 757424001373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424001374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001375 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424001376 putative effector binding pocket; other site 757424001377 dimerization interface [polypeptide binding]; other site 757424001378 NmrA-like family; Region: NmrA; pfam05368 757424001379 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 757424001380 NADP binding site [chemical binding]; other site 757424001381 active site 757424001382 regulatory binding site [polypeptide binding]; other site 757424001383 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424001384 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 757424001385 putative substrate binding site [chemical binding]; other site 757424001386 putative ATP binding site [chemical binding]; other site 757424001387 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 757424001388 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 757424001389 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424001390 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 757424001391 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 757424001392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001393 dimer interface [polypeptide binding]; other site 757424001394 conserved gate region; other site 757424001395 putative PBP binding loops; other site 757424001396 ABC-ATPase subunit interface; other site 757424001397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424001398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001399 dimer interface [polypeptide binding]; other site 757424001400 conserved gate region; other site 757424001401 putative PBP binding loops; other site 757424001402 ABC-ATPase subunit interface; other site 757424001403 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 757424001404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424001405 motif II; other site 757424001406 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 757424001407 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 757424001408 Walker A/P-loop; other site 757424001409 ATP binding site [chemical binding]; other site 757424001410 Q-loop/lid; other site 757424001411 ABC transporter signature motif; other site 757424001412 Walker B; other site 757424001413 D-loop; other site 757424001414 H-loop/switch region; other site 757424001415 TOBE domain; Region: TOBE_2; pfam08402 757424001416 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 757424001417 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 757424001418 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 757424001419 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 757424001420 N- and C-terminal domain interface [polypeptide binding]; other site 757424001421 D-xylulose kinase; Region: XylB; TIGR01312 757424001422 active site 757424001423 MgATP binding site [chemical binding]; other site 757424001424 catalytic site [active] 757424001425 metal binding site [ion binding]; metal-binding site 757424001426 xylulose binding site [chemical binding]; other site 757424001427 homodimer interface [polypeptide binding]; other site 757424001428 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 757424001429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424001430 Coenzyme A binding pocket [chemical binding]; other site 757424001431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424001432 PAS domain; Region: PAS_9; pfam13426 757424001433 putative active site [active] 757424001434 heme pocket [chemical binding]; other site 757424001435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424001436 dimerization interface [polypeptide binding]; other site 757424001437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424001438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424001439 dimer interface [polypeptide binding]; other site 757424001440 putative CheW interface [polypeptide binding]; other site 757424001441 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 757424001442 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 757424001443 putative active site [active] 757424001444 putative substrate binding site [chemical binding]; other site 757424001445 ATP binding site [chemical binding]; other site 757424001446 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 757424001447 DNA polymerase I; Provisional; Region: PRK05755 757424001448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 757424001449 active site 757424001450 metal binding site 1 [ion binding]; metal-binding site 757424001451 putative 5' ssDNA interaction site; other site 757424001452 metal binding site 3; metal-binding site 757424001453 metal binding site 2 [ion binding]; metal-binding site 757424001454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 757424001455 putative DNA binding site [nucleotide binding]; other site 757424001456 putative metal binding site [ion binding]; other site 757424001457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 757424001458 active site 757424001459 catalytic site [active] 757424001460 substrate binding site [chemical binding]; other site 757424001461 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 757424001462 active site 757424001463 DNA binding site [nucleotide binding] 757424001464 catalytic site [active] 757424001465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424001466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424001467 dimer interface [polypeptide binding]; other site 757424001468 putative CheW interface [polypeptide binding]; other site 757424001469 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 757424001470 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 757424001471 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 757424001472 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 757424001473 FMN-binding pocket [chemical binding]; other site 757424001474 flavin binding motif; other site 757424001475 phosphate binding motif [ion binding]; other site 757424001476 beta-alpha-beta structure motif; other site 757424001477 NAD binding pocket [chemical binding]; other site 757424001478 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424001479 catalytic loop [active] 757424001480 iron binding site [ion binding]; other site 757424001481 NMT1/THI5 like; Region: NMT1; pfam09084 757424001482 oxidase reductase; Provisional; Region: PTZ00273 757424001483 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 757424001484 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 757424001485 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 757424001486 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 757424001487 iron-sulfur cluster [ion binding]; other site 757424001488 [2Fe-2S] cluster binding site [ion binding]; other site 757424001489 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 757424001490 hydrophobic ligand binding site; other site 757424001491 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424001492 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424001493 Walker A/P-loop; other site 757424001494 ATP binding site [chemical binding]; other site 757424001495 Q-loop/lid; other site 757424001496 ABC transporter signature motif; other site 757424001497 Walker B; other site 757424001498 D-loop; other site 757424001499 H-loop/switch region; other site 757424001500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001502 dimer interface [polypeptide binding]; other site 757424001503 conserved gate region; other site 757424001504 putative PBP binding loops; other site 757424001505 ABC-ATPase subunit interface; other site 757424001506 amidohydrolase; Provisional; Region: PRK12393 757424001507 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 757424001508 active site 757424001509 putative substrate binding pocket [chemical binding]; other site 757424001510 hypothetical protein; Validated; Region: PRK00228 757424001511 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 757424001512 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 757424001513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424001514 active site 757424001515 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 757424001516 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 757424001517 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 757424001518 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 757424001519 GIY-YIG motif/motif A; other site 757424001520 putative active site [active] 757424001521 putative metal binding site [ion binding]; other site 757424001522 dihydroorotase; Provisional; Region: PRK07627 757424001523 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424001524 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 757424001525 active site 757424001526 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 757424001527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424001528 putative acyl-acceptor binding pocket; other site 757424001529 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 757424001530 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 757424001531 active site 757424001532 metal binding site [ion binding]; metal-binding site 757424001533 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 757424001534 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 757424001535 active site 757424001536 substrate binding site [chemical binding]; other site 757424001537 metal binding site [ion binding]; metal-binding site 757424001538 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 757424001539 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 757424001540 putative active site [active] 757424001541 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 757424001542 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 757424001543 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 757424001544 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424001545 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 757424001546 putative NAD(P) binding site [chemical binding]; other site 757424001547 active site 757424001548 putative substrate binding site [chemical binding]; other site 757424001549 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 757424001550 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 757424001551 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 757424001552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424001553 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424001554 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 757424001555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424001556 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 757424001557 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 757424001558 transcriptional activator RfaH; Region: RfaH; TIGR01955 757424001559 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 757424001560 heterodimer interface [polypeptide binding]; other site 757424001561 homodimer interface [polypeptide binding]; other site 757424001562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 757424001563 active site residue [active] 757424001564 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 757424001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424001566 S-adenosylmethionine binding site [chemical binding]; other site 757424001567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424001568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424001569 Flagellin N-methylase; Region: FliB; pfam03692 757424001570 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 757424001571 ArsC family; Region: ArsC; pfam03960 757424001572 catalytic residues [active] 757424001573 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 757424001574 Bacitracin resistance protein BacA; Region: BacA; pfam02673 757424001575 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 757424001576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424001577 ATP binding site [chemical binding]; other site 757424001578 putative Mg++ binding site [ion binding]; other site 757424001579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424001580 nucleotide binding region [chemical binding]; other site 757424001581 ATP-binding site [chemical binding]; other site 757424001582 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 757424001583 HRDC domain; Region: HRDC; pfam00570 757424001584 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 757424001585 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 757424001586 active site 757424001587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424001588 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 757424001589 ligand binding site [chemical binding]; other site 757424001590 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 757424001591 Cache domain; Region: Cache_1; pfam02743 757424001592 GAF domain; Region: GAF_3; pfam13492 757424001593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424001594 Zn2+ binding site [ion binding]; other site 757424001595 Mg2+ binding site [ion binding]; other site 757424001596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424001597 Zn2+ binding site [ion binding]; other site 757424001598 Mg2+ binding site [ion binding]; other site 757424001599 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 757424001600 DNA-binding site [nucleotide binding]; DNA binding site 757424001601 RNA-binding motif; other site 757424001602 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 757424001603 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 757424001604 TPP-binding site [chemical binding]; other site 757424001605 dimer interface [polypeptide binding]; other site 757424001606 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 757424001607 PYR/PP interface [polypeptide binding]; other site 757424001608 dimer interface [polypeptide binding]; other site 757424001609 TPP binding site [chemical binding]; other site 757424001610 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 757424001611 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 757424001612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424001613 catalytic residue [active] 757424001614 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 757424001615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424001616 DNA-binding site [nucleotide binding]; DNA binding site 757424001617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424001618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424001619 homodimer interface [polypeptide binding]; other site 757424001620 catalytic residue [active] 757424001621 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 757424001622 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 757424001623 catalytic triad [active] 757424001624 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424001625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001626 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424001627 dimerization interface [polypeptide binding]; other site 757424001628 substrate binding pocket [chemical binding]; other site 757424001629 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424001630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424001631 NAD(P) binding site [chemical binding]; other site 757424001632 active site 757424001633 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 757424001634 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 757424001635 Predicted membrane protein [Function unknown]; Region: COG2860 757424001636 UPF0126 domain; Region: UPF0126; pfam03458 757424001637 UPF0126 domain; Region: UPF0126; pfam03458 757424001638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424001639 PAS domain; Region: PAS_9; pfam13426 757424001640 putative active site [active] 757424001641 heme pocket [chemical binding]; other site 757424001642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424001643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424001644 dimer interface [polypeptide binding]; other site 757424001645 putative CheW interface [polypeptide binding]; other site 757424001646 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 757424001647 homodimer interface [polypeptide binding]; other site 757424001648 chemical substrate binding site [chemical binding]; other site 757424001649 oligomer interface [polypeptide binding]; other site 757424001650 metal binding site [ion binding]; metal-binding site 757424001651 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 757424001652 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424001653 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424001654 metal binding site [ion binding]; metal-binding site 757424001655 active site 757424001656 I-site; other site 757424001657 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 757424001658 Predicted transcriptional regulator [Transcription]; Region: COG2378 757424001659 HTH domain; Region: HTH_11; pfam08279 757424001660 WYL domain; Region: WYL; pfam13280 757424001661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424001662 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 757424001663 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 757424001664 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 757424001665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424001666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001667 LysR substrate binding domain; Region: LysR_substrate; pfam03466 757424001668 dimerization interface [polypeptide binding]; other site 757424001669 Protein of unknown function (DUF342); Region: DUF342; pfam03961 757424001670 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 757424001671 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 757424001672 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 757424001673 Predicted membrane protein [Function unknown]; Region: COG1971 757424001674 Domain of unknown function DUF; Region: DUF204; pfam02659 757424001675 Domain of unknown function DUF; Region: DUF204; pfam02659 757424001676 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 757424001677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424001679 dimerization interface [polypeptide binding]; other site 757424001680 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 757424001681 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 757424001682 putative ligand binding site [chemical binding]; other site 757424001683 NAD binding site [chemical binding]; other site 757424001684 catalytic site [active] 757424001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001686 D-galactonate transporter; Region: 2A0114; TIGR00893 757424001687 putative substrate translocation pore; other site 757424001688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001689 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 757424001690 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 757424001691 Domain of unknown function DUF20; Region: UPF0118; pfam01594 757424001692 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424001693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424001694 N-terminal plug; other site 757424001695 ligand-binding site [chemical binding]; other site 757424001696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 757424001697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424001698 putative metal binding site [ion binding]; other site 757424001699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424001700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 757424001702 putative substrate binding pocket [chemical binding]; other site 757424001703 putative dimerization interface [polypeptide binding]; other site 757424001704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001706 putative substrate translocation pore; other site 757424001707 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424001708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424001709 dimer interface [polypeptide binding]; other site 757424001710 putative CheW interface [polypeptide binding]; other site 757424001711 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424001712 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424001713 Walker A/P-loop; other site 757424001714 ATP binding site [chemical binding]; other site 757424001715 Q-loop/lid; other site 757424001716 ABC transporter signature motif; other site 757424001717 Walker B; other site 757424001718 D-loop; other site 757424001719 H-loop/switch region; other site 757424001720 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 757424001721 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 757424001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001723 dimer interface [polypeptide binding]; other site 757424001724 conserved gate region; other site 757424001725 putative PBP binding loops; other site 757424001726 ABC-ATPase subunit interface; other site 757424001727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001728 dimer interface [polypeptide binding]; other site 757424001729 conserved gate region; other site 757424001730 putative PBP binding loops; other site 757424001731 ABC-ATPase subunit interface; other site 757424001732 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 757424001733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001734 putative substrate translocation pore; other site 757424001735 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 757424001736 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 757424001737 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424001738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424001739 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424001740 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424001741 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424001742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 757424001743 putative active site [active] 757424001744 heme pocket [chemical binding]; other site 757424001745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424001746 PAS domain; Region: PAS_9; pfam13426 757424001747 putative active site [active] 757424001748 heme pocket [chemical binding]; other site 757424001749 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424001750 GAF domain; Region: GAF; pfam01590 757424001751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424001752 dimer interface [polypeptide binding]; other site 757424001753 phosphorylation site [posttranslational modification] 757424001754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424001755 ATP binding site [chemical binding]; other site 757424001756 Mg2+ binding site [ion binding]; other site 757424001757 G-X-G motif; other site 757424001758 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424001759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424001760 active site 757424001761 phosphorylation site [posttranslational modification] 757424001762 intermolecular recognition site; other site 757424001763 dimerization interface [polypeptide binding]; other site 757424001764 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 757424001765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424001766 metal binding site [ion binding]; metal-binding site 757424001767 active site 757424001768 I-site; other site 757424001769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424001770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 757424001771 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 757424001772 dimanganese center [ion binding]; other site 757424001773 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 757424001774 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 757424001775 dimerization interface [polypeptide binding]; other site 757424001776 metal binding site [ion binding]; metal-binding site 757424001777 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 757424001778 putative active site [active] 757424001779 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 757424001780 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 757424001781 NAD binding site [chemical binding]; other site 757424001782 catalytic Zn binding site [ion binding]; other site 757424001783 structural Zn binding site [ion binding]; other site 757424001784 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 757424001785 methionine synthase; Provisional; Region: PRK01207 757424001786 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 757424001787 substrate binding site [chemical binding]; other site 757424001788 THF binding site; other site 757424001789 zinc-binding site [ion binding]; other site 757424001790 MgtC family; Region: MgtC; pfam02308 757424001791 Predicted transcriptional regulators [Transcription]; Region: COG1733 757424001792 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 757424001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001794 putative substrate translocation pore; other site 757424001795 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424001796 Methyltransferase domain; Region: Methyltransf_31; pfam13847 757424001797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424001798 S-adenosylmethionine binding site [chemical binding]; other site 757424001799 Predicted transcriptional regulators [Transcription]; Region: COG1733 757424001800 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 757424001801 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424001802 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424001803 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 757424001804 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 757424001805 catalytic residues [active] 757424001806 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 757424001807 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424001808 active site 757424001809 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424001810 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 757424001811 Amidase; Region: Amidase; pfam01425 757424001812 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 757424001813 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 757424001814 active site 757424001815 putative substrate binding pocket [chemical binding]; other site 757424001816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001817 D-galactonate transporter; Region: 2A0114; TIGR00893 757424001818 putative substrate translocation pore; other site 757424001819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424001820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424001822 dimerization interface [polypeptide binding]; other site 757424001823 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424001824 Predicted transcriptional regulators [Transcription]; Region: COG1733 757424001825 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 757424001826 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424001828 S-adenosylmethionine binding site [chemical binding]; other site 757424001829 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424001830 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 757424001831 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 757424001832 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 757424001833 putative active site [active] 757424001834 putative metal binding site [ion binding]; other site 757424001835 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 757424001836 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424001837 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424001838 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424001839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424001840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424001841 NAD(P) binding site [chemical binding]; other site 757424001842 active site 757424001843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424001844 D-galactonate transporter; Region: 2A0114; TIGR00893 757424001845 putative substrate translocation pore; other site 757424001846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424001847 classical (c) SDRs; Region: SDR_c; cd05233 757424001848 NAD(P) binding site [chemical binding]; other site 757424001849 active site 757424001850 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 757424001851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424001852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424001853 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424001854 putative effector binding pocket; other site 757424001855 dimerization interface [polypeptide binding]; other site 757424001856 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 757424001857 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 757424001858 putative active site [active] 757424001859 metal binding site [ion binding]; metal-binding site 757424001860 Predicted membrane protein [Function unknown]; Region: COG2259 757424001861 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 757424001862 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 757424001863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 757424001864 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 757424001865 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 757424001866 putative catalytic residue [active] 757424001867 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 757424001868 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 757424001869 putative catalytic cysteine [active] 757424001870 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 757424001871 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 757424001872 Lipopolysaccharide-assembly; Region: LptE; cl01125 757424001873 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 757424001874 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 757424001875 HIGH motif; other site 757424001876 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 757424001877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424001878 active site 757424001879 KMSKS motif; other site 757424001880 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 757424001881 tRNA binding surface [nucleotide binding]; other site 757424001882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424001883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424001884 DNA binding site [nucleotide binding] 757424001885 domain linker motif; other site 757424001886 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 757424001887 putative dimerization interface [polypeptide binding]; other site 757424001888 putative ligand binding site [chemical binding]; other site 757424001889 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 757424001890 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 757424001891 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 757424001892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001893 dimer interface [polypeptide binding]; other site 757424001894 conserved gate region; other site 757424001895 putative PBP binding loops; other site 757424001896 ABC-ATPase subunit interface; other site 757424001897 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 757424001898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424001899 dimer interface [polypeptide binding]; other site 757424001900 conserved gate region; other site 757424001901 putative PBP binding loops; other site 757424001902 ABC-ATPase subunit interface; other site 757424001903 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 757424001904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424001905 Walker A/P-loop; other site 757424001906 ATP binding site [chemical binding]; other site 757424001907 Q-loop/lid; other site 757424001908 ABC transporter signature motif; other site 757424001909 Walker B; other site 757424001910 D-loop; other site 757424001911 H-loop/switch region; other site 757424001912 TOBE domain; Region: TOBE_2; pfam08402 757424001913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 757424001914 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 757424001915 active site 757424001916 metal binding site [ion binding]; metal-binding site 757424001917 hexamer interface [polypeptide binding]; other site 757424001918 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 757424001919 RNAase interaction site [polypeptide binding]; other site 757424001920 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424001921 TolR protein; Region: tolR; TIGR02801 757424001922 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 757424001923 dihydrodipicolinate reductase; Provisional; Region: PRK00048 757424001924 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 757424001925 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 757424001926 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 757424001927 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 757424001928 ferric uptake regulator; Provisional; Region: fur; PRK09462 757424001929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 757424001930 metal binding site 2 [ion binding]; metal-binding site 757424001931 putative DNA binding helix; other site 757424001932 metal binding site 1 [ion binding]; metal-binding site 757424001933 dimer interface [polypeptide binding]; other site 757424001934 structural Zn2+ binding site [ion binding]; other site 757424001935 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 757424001936 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 757424001937 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 757424001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424001939 active site 757424001940 motif I; other site 757424001941 motif II; other site 757424001942 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 757424001943 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 757424001944 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 757424001945 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 757424001946 Walker A/P-loop; other site 757424001947 ATP binding site [chemical binding]; other site 757424001948 Q-loop/lid; other site 757424001949 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 757424001950 ABC transporter signature motif; other site 757424001951 Walker B; other site 757424001952 D-loop; other site 757424001953 H-loop/switch region; other site 757424001954 ferrochelatase; Reviewed; Region: hemH; PRK00035 757424001955 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 757424001956 C-terminal domain interface [polypeptide binding]; other site 757424001957 active site 757424001958 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 757424001959 active site 757424001960 N-terminal domain interface [polypeptide binding]; other site 757424001961 GrpE; Region: GrpE; pfam01025 757424001962 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 757424001963 dimer interface [polypeptide binding]; other site 757424001964 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 757424001965 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 757424001966 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 757424001967 nucleotide binding site [chemical binding]; other site 757424001968 chaperone protein DnaJ; Provisional; Region: PRK10767 757424001969 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 757424001970 HSP70 interaction site [polypeptide binding]; other site 757424001971 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 757424001972 substrate binding site [polypeptide binding]; other site 757424001973 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 757424001974 Zn binding sites [ion binding]; other site 757424001975 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 757424001976 dimer interface [polypeptide binding]; other site 757424001977 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 757424001978 oligomerization interface [polypeptide binding]; other site 757424001979 active site 757424001980 metal binding site [ion binding]; metal-binding site 757424001981 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 757424001982 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 757424001983 Substrate-binding site [chemical binding]; other site 757424001984 Substrate specificity [chemical binding]; other site 757424001985 Response regulator receiver domain; Region: Response_reg; pfam00072 757424001986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424001987 active site 757424001988 phosphorylation site [posttranslational modification] 757424001989 intermolecular recognition site; other site 757424001990 dimerization interface [polypeptide binding]; other site 757424001991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 757424001992 anti sigma factor interaction site; other site 757424001993 regulatory phosphorylation site [posttranslational modification]; other site 757424001994 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424001995 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 757424001996 putative binding surface; other site 757424001997 active site 757424001998 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 757424001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424002000 ATP binding site [chemical binding]; other site 757424002001 Mg2+ binding site [ion binding]; other site 757424002002 G-X-G motif; other site 757424002003 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 757424002004 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424002005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424002006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424002007 dimer interface [polypeptide binding]; other site 757424002008 putative CheW interface [polypeptide binding]; other site 757424002009 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424002010 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 757424002011 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 757424002012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424002013 S-adenosylmethionine binding site [chemical binding]; other site 757424002014 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 757424002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002016 active site 757424002017 phosphorylation site [posttranslational modification] 757424002018 intermolecular recognition site; other site 757424002019 dimerization interface [polypeptide binding]; other site 757424002020 CheB methylesterase; Region: CheB_methylest; pfam01339 757424002021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002022 Response regulator receiver domain; Region: Response_reg; pfam00072 757424002023 active site 757424002024 phosphorylation site [posttranslational modification] 757424002025 intermolecular recognition site; other site 757424002026 dimerization interface [polypeptide binding]; other site 757424002027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424002028 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 757424002029 catalytic center binding site [active] 757424002030 ATP binding site [chemical binding]; other site 757424002031 poly(A) polymerase; Region: pcnB; TIGR01942 757424002032 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 757424002033 active site 757424002034 NTP binding site [chemical binding]; other site 757424002035 metal binding triad [ion binding]; metal-binding site 757424002036 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 757424002037 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 757424002038 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 757424002039 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 757424002040 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 757424002041 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 757424002042 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 757424002043 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 757424002044 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 757424002045 dimerization interface [polypeptide binding]; other site 757424002046 putative ATP binding site [chemical binding]; other site 757424002047 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 757424002048 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 757424002049 active site 757424002050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 757424002051 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 757424002052 Uncharacterized conserved protein [Function unknown]; Region: COG2308 757424002053 Cupin domain; Region: Cupin_2; cl17218 757424002054 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 757424002055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424002056 putative C-terminal domain interface [polypeptide binding]; other site 757424002057 putative GSH binding site (G-site) [chemical binding]; other site 757424002058 putative dimer interface [polypeptide binding]; other site 757424002059 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 757424002060 putative dimer interface [polypeptide binding]; other site 757424002061 putative N-terminal domain interface [polypeptide binding]; other site 757424002062 putative substrate binding pocket (H-site) [chemical binding]; other site 757424002063 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 757424002064 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 757424002065 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 757424002066 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 757424002067 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 757424002068 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 757424002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 757424002070 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 757424002071 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 757424002072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 757424002073 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 757424002074 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 757424002075 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 757424002076 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 757424002077 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 757424002078 Na binding site [ion binding]; other site 757424002079 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 757424002080 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424002081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424002082 HAMP domain; Region: HAMP; pfam00672 757424002083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424002084 dimer interface [polypeptide binding]; other site 757424002085 phosphorylation site [posttranslational modification] 757424002086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424002087 ATP binding site [chemical binding]; other site 757424002088 Mg2+ binding site [ion binding]; other site 757424002089 G-X-G motif; other site 757424002090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424002091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002092 active site 757424002093 phosphorylation site [posttranslational modification] 757424002094 intermolecular recognition site; other site 757424002095 dimerization interface [polypeptide binding]; other site 757424002096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424002097 DNA binding site [nucleotide binding] 757424002098 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 757424002099 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424002100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424002101 substrate binding pocket [chemical binding]; other site 757424002102 membrane-bound complex binding site; other site 757424002103 hinge residues; other site 757424002104 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424002106 ABC-ATPase subunit interface; other site 757424002107 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424002108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424002109 substrate binding pocket [chemical binding]; other site 757424002110 membrane-bound complex binding site; other site 757424002111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424002112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424002113 ATP binding site [chemical binding]; other site 757424002114 Mg2+ binding site [ion binding]; other site 757424002115 G-X-G motif; other site 757424002116 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 757424002117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002118 active site 757424002119 phosphorylation site [posttranslational modification] 757424002120 intermolecular recognition site; other site 757424002121 dimerization interface [polypeptide binding]; other site 757424002122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424002123 binding surface 757424002124 TPR motif; other site 757424002125 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 757424002126 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 757424002127 hexamer interface [polypeptide binding]; other site 757424002128 Walker A motif; other site 757424002129 ATP binding site [chemical binding]; other site 757424002130 Walker B motif; other site 757424002131 RecX family; Region: RecX; cl00936 757424002132 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 757424002133 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 757424002134 CoA-ligase; Region: Ligase_CoA; pfam00549 757424002135 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 757424002136 CoA binding domain; Region: CoA_binding; smart00881 757424002137 CoA-ligase; Region: Ligase_CoA; pfam00549 757424002138 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 757424002139 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 757424002140 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 757424002141 Pilin (bacterial filament); Region: Pilin; pfam00114 757424002142 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 757424002143 trimer interface [polypeptide binding]; other site 757424002144 dimer interface [polypeptide binding]; other site 757424002145 putative active site [active] 757424002146 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 757424002147 Peptidase family M48; Region: Peptidase_M48; pfam01435 757424002148 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 757424002149 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 757424002150 SnoaL-like domain; Region: SnoaL_3; pfam13474 757424002151 Zinc-finger domain; Region: zf-CHCC; cl01821 757424002152 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 757424002153 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 757424002154 homodimer interface [polypeptide binding]; other site 757424002155 substrate-cofactor binding pocket; other site 757424002156 catalytic residue [active] 757424002157 AzlC protein; Region: AzlC; cl00570 757424002158 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 757424002159 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 757424002160 Phosphoglycerate kinase; Region: PGK; pfam00162 757424002161 substrate binding site [chemical binding]; other site 757424002162 hinge regions; other site 757424002163 ADP binding site [chemical binding]; other site 757424002164 catalytic site [active] 757424002165 pyruvate kinase; Provisional; Region: PRK05826 757424002166 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 757424002167 domain interfaces; other site 757424002168 active site 757424002169 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 757424002170 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 757424002171 intersubunit interface [polypeptide binding]; other site 757424002172 active site 757424002173 zinc binding site [ion binding]; other site 757424002174 Na+ binding site [ion binding]; other site 757424002175 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 757424002176 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 757424002177 ATP binding site [chemical binding]; other site 757424002178 active site 757424002179 substrate binding site [chemical binding]; other site 757424002180 AIR carboxylase; Region: AIRC; pfam00731 757424002181 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 757424002182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424002183 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 757424002184 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 757424002185 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 757424002186 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 757424002187 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 757424002188 methionine sulfoxide reductase A; Provisional; Region: PRK14054 757424002189 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 757424002190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424002191 S-adenosylmethionine binding site [chemical binding]; other site 757424002192 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 757424002193 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 757424002194 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 757424002195 Uncharacterized conserved protein [Function unknown]; Region: COG2353 757424002196 YceI-like domain; Region: YceI; smart00867 757424002197 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 757424002198 adenylosuccinate lyase; Provisional; Region: PRK09285 757424002199 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 757424002200 tetramer interface [polypeptide binding]; other site 757424002201 active site 757424002202 putative glutathione S-transferase; Provisional; Region: PRK10357 757424002203 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 757424002204 putative C-terminal domain interface [polypeptide binding]; other site 757424002205 putative GSH binding site (G-site) [chemical binding]; other site 757424002206 putative dimer interface [polypeptide binding]; other site 757424002207 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 757424002208 dimer interface [polypeptide binding]; other site 757424002209 N-terminal domain interface [polypeptide binding]; other site 757424002210 putative substrate binding pocket (H-site) [chemical binding]; other site 757424002211 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 757424002212 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 757424002213 heme binding site [chemical binding]; other site 757424002214 ferroxidase pore; other site 757424002215 ferroxidase diiron center [ion binding]; other site 757424002216 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424002217 TolR protein; Region: tolR; TIGR02801 757424002218 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 757424002219 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 757424002220 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 757424002221 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 757424002222 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 757424002223 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 757424002224 Ligand Binding Site [chemical binding]; other site 757424002225 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 757424002226 nudix motif; other site 757424002227 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 757424002228 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 757424002229 ligand binding site [chemical binding]; other site 757424002230 homodimer interface [polypeptide binding]; other site 757424002231 NAD(P) binding site [chemical binding]; other site 757424002232 trimer interface B [polypeptide binding]; other site 757424002233 trimer interface A [polypeptide binding]; other site 757424002234 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 757424002235 tetramerization interface [polypeptide binding]; other site 757424002236 active site 757424002237 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 757424002238 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 757424002239 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 757424002240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424002241 active site 757424002242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424002243 hypothetical protein; Provisional; Region: PRK06996 757424002244 proline aminopeptidase P II; Provisional; Region: PRK10879 757424002245 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 757424002246 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 757424002247 active site 757424002248 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 757424002249 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 757424002250 Substrate binding site; other site 757424002251 metal-binding site 757424002252 Phosphotransferase enzyme family; Region: APH; pfam01636 757424002253 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 757424002254 substrate binding site [chemical binding]; other site 757424002255 organic solvent tolerance protein; Provisional; Region: PRK04423 757424002256 Organic solvent tolerance protein; Region: OstA_C; pfam04453 757424002257 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 757424002258 SurA N-terminal domain; Region: SurA_N; pfam09312 757424002259 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 757424002260 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 757424002261 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 757424002262 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 757424002263 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 757424002264 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 757424002265 dimer interface [polypeptide binding]; other site 757424002266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424002267 active site 757424002268 metal binding site [ion binding]; metal-binding site 757424002269 glutathione binding site [chemical binding]; other site 757424002270 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 757424002271 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 757424002272 putative ion selectivity filter; other site 757424002273 putative pore gating glutamate residue; other site 757424002274 putative H+/Cl- coupling transport residue; other site 757424002275 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 757424002276 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 757424002277 Protein of unknown function DUF45; Region: DUF45; pfam01863 757424002278 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 757424002279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424002280 putative acyl-acceptor binding pocket; other site 757424002281 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 757424002282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424002283 active site 757424002284 motif I; other site 757424002285 motif II; other site 757424002286 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 757424002287 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 757424002288 DALR anticodon binding domain; Region: DALR_1; smart00836 757424002289 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 757424002290 dimer interface [polypeptide binding]; other site 757424002291 motif 1; other site 757424002292 active site 757424002293 motif 2; other site 757424002294 motif 3; other site 757424002295 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 757424002296 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 757424002297 putative active site [active] 757424002298 catalytic triad [active] 757424002299 putative dimer interface [polypeptide binding]; other site 757424002300 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 757424002301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 757424002302 Transporter associated domain; Region: CorC_HlyC; smart01091 757424002303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424002304 dimerization interface [polypeptide binding]; other site 757424002305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424002306 dimer interface [polypeptide binding]; other site 757424002307 putative CheW interface [polypeptide binding]; other site 757424002308 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 757424002309 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 757424002310 PhoH-like protein; Region: PhoH; pfam02562 757424002311 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 757424002312 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 757424002313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424002314 FeS/SAM binding site; other site 757424002315 TRAM domain; Region: TRAM; pfam01938 757424002316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424002317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424002319 dimerization interface [polypeptide binding]; other site 757424002320 Isochorismatase family; Region: Isochorismatase; pfam00857 757424002321 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 757424002322 catalytic triad [active] 757424002323 conserved cis-peptide bond; other site 757424002324 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 757424002325 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 757424002326 active site 757424002327 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 757424002328 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424002329 putative ligand binding site [chemical binding]; other site 757424002330 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424002331 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424002332 Walker A/P-loop; other site 757424002333 ATP binding site [chemical binding]; other site 757424002334 Q-loop/lid; other site 757424002335 ABC transporter signature motif; other site 757424002336 Walker B; other site 757424002337 D-loop; other site 757424002338 H-loop/switch region; other site 757424002339 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424002340 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424002341 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424002342 TM-ABC transporter signature motif; other site 757424002343 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 757424002344 dimerization interface [polypeptide binding]; other site 757424002345 putative active cleft [active] 757424002346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424002347 substrate binding pocket [chemical binding]; other site 757424002348 membrane-bound complex binding site; other site 757424002349 hinge residues; other site 757424002350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424002351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424002352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424002353 metal binding site [ion binding]; metal-binding site 757424002354 active site 757424002355 I-site; other site 757424002356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 757424002357 FAD binding domain; Region: FAD_binding_4; pfam01565 757424002358 Berberine and berberine like; Region: BBE; pfam08031 757424002359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424002360 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424002361 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424002362 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424002363 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424002364 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 757424002365 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 757424002366 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 757424002367 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 757424002368 Tetratricopeptide repeat; Region: TPR_16; pfam13432 757424002369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424002370 TPR motif; other site 757424002371 Protein of unknown function (DUF770); Region: DUF770; pfam05591 757424002372 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 757424002373 Protein of unknown function (DUF877); Region: DUF877; pfam05943 757424002374 Protein of unknown function (DUF796); Region: DUF796; pfam05638 757424002375 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 757424002376 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 757424002377 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 757424002378 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 757424002379 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 757424002380 Clp amino terminal domain; Region: Clp_N; pfam02861 757424002381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424002382 Walker A motif; other site 757424002383 ATP binding site [chemical binding]; other site 757424002384 Walker B motif; other site 757424002385 arginine finger; other site 757424002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424002387 Walker A motif; other site 757424002388 ATP binding site [chemical binding]; other site 757424002389 Walker B motif; other site 757424002390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 757424002391 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 757424002392 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424002393 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424002394 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424002395 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424002396 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 757424002397 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 757424002398 BON domain; Region: BON; pfam04972 757424002399 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 757424002400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424002401 ligand binding site [chemical binding]; other site 757424002402 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 757424002403 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 757424002404 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 757424002405 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 757424002406 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 757424002407 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 757424002408 PAAR motif; Region: PAAR_motif; pfam05488 757424002409 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 757424002410 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 757424002411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424002412 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424002413 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424002414 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424002415 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424002416 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 757424002417 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 757424002418 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 757424002419 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 757424002420 putative aminotransferase; Provisional; Region: PRK12403 757424002421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 757424002422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424002423 catalytic residue [active] 757424002424 Tir chaperone protein (CesT) family; Region: CesT; cl08444 757424002425 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 757424002426 Methyltransferase domain; Region: Methyltransf_31; pfam13847 757424002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424002428 S-adenosylmethionine binding site [chemical binding]; other site 757424002429 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 757424002430 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 757424002431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424002432 tetratricopeptide repeat protein; Provisional; Region: PRK11788 757424002433 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 757424002434 FHIPEP family; Region: FHIPEP; pfam00771 757424002435 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 757424002436 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 757424002437 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 757424002438 Walker A motif/ATP binding site; other site 757424002439 Walker B motif; other site 757424002440 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 757424002441 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 757424002442 type III secretion system protein YscR; Provisional; Region: PRK12797 757424002443 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 757424002444 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 757424002445 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 757424002446 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 757424002447 Flagellar assembly protein FliH; Region: FliH; pfam02108 757424002448 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 757424002449 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 757424002450 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 757424002451 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 757424002452 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 757424002453 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 757424002454 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 757424002455 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 757424002456 Walker A motif; other site 757424002457 ATP binding site [chemical binding]; other site 757424002458 Walker B motif; other site 757424002459 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 757424002460 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 757424002461 PilS N terminal; Region: PilS; pfam08805 757424002462 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 757424002463 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 757424002464 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424002465 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424002466 catalytic residue [active] 757424002467 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 757424002468 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 757424002469 Walker A motif; other site 757424002470 ATP binding site [chemical binding]; other site 757424002471 Walker B motif; other site 757424002472 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 757424002473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424002474 active site 757424002475 Tir chaperone protein (CesT) family; Region: CesT; cl08444 757424002476 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 757424002477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424002478 substrate binding site [chemical binding]; other site 757424002479 oxyanion hole (OAH) forming residues; other site 757424002480 trimer interface [polypeptide binding]; other site 757424002481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424002482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002483 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 757424002484 dimerization interface [polypeptide binding]; other site 757424002485 substrate binding pocket [chemical binding]; other site 757424002486 citrate-proton symporter; Provisional; Region: PRK15075 757424002487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424002488 putative substrate translocation pore; other site 757424002489 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 757424002490 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 757424002491 metal binding site [ion binding]; metal-binding site 757424002492 putative dimer interface [polypeptide binding]; other site 757424002493 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 757424002494 glutaminase; Provisional; Region: PRK00971 757424002495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424002496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002497 active site 757424002498 phosphorylation site [posttranslational modification] 757424002499 intermolecular recognition site; other site 757424002500 dimerization interface [polypeptide binding]; other site 757424002501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424002502 DNA binding site [nucleotide binding] 757424002503 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 757424002504 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 757424002505 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 757424002506 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 757424002507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424002508 ATP binding site [chemical binding]; other site 757424002509 Mg2+ binding site [ion binding]; other site 757424002510 G-X-G motif; other site 757424002511 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 757424002512 ATP binding site [chemical binding]; other site 757424002513 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 757424002514 Cache domain; Region: Cache_1; pfam02743 757424002515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424002516 dimerization interface [polypeptide binding]; other site 757424002517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424002518 dimer interface [polypeptide binding]; other site 757424002519 putative CheW interface [polypeptide binding]; other site 757424002520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424002521 PAS domain; Region: PAS_9; pfam13426 757424002522 putative active site [active] 757424002523 heme pocket [chemical binding]; other site 757424002524 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 757424002525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424002526 putative active site [active] 757424002527 heme pocket [chemical binding]; other site 757424002528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424002529 putative active site [active] 757424002530 heme pocket [chemical binding]; other site 757424002531 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 757424002532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424002533 metal binding site [ion binding]; metal-binding site 757424002534 active site 757424002535 I-site; other site 757424002536 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424002537 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 757424002538 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 757424002539 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 757424002540 AMIN domain; Region: AMIN; pfam11741 757424002541 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 757424002542 active site 757424002543 metal binding site [ion binding]; metal-binding site 757424002544 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 757424002545 epoxyqueuosine reductase; Region: TIGR00276 757424002546 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 757424002547 Predicted permeases [General function prediction only]; Region: COG0679 757424002548 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 757424002549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002550 active site 757424002551 phosphorylation site [posttranslational modification] 757424002552 intermolecular recognition site; other site 757424002553 dimerization interface [polypeptide binding]; other site 757424002554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424002555 DNA binding residues [nucleotide binding] 757424002556 dimerization interface [polypeptide binding]; other site 757424002557 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 757424002558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424002559 putative active site [active] 757424002560 heme pocket [chemical binding]; other site 757424002561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424002562 dimer interface [polypeptide binding]; other site 757424002563 phosphorylation site [posttranslational modification] 757424002564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424002565 ATP binding site [chemical binding]; other site 757424002566 Mg2+ binding site [ion binding]; other site 757424002567 G-X-G motif; other site 757424002568 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 757424002569 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 757424002570 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 757424002571 DctM-like transporters; Region: DctM; pfam06808 757424002572 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 757424002573 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 757424002574 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 757424002575 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 757424002576 DNA binding site [nucleotide binding] 757424002577 active site 757424002578 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 757424002579 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 757424002580 active site 757424002581 Int/Topo IB signature motif; other site 757424002582 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 757424002583 putative deacylase active site [active] 757424002584 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 757424002585 UGMP family protein; Validated; Region: PRK09604 757424002586 glycosyl transferase family protein; Provisional; Region: PRK08136 757424002587 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 757424002588 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424002589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424002590 metal binding site [ion binding]; metal-binding site 757424002591 active site 757424002592 I-site; other site 757424002593 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424002594 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 757424002595 putative efflux protein, MATE family; Region: matE; TIGR00797 757424002596 cation binding site [ion binding]; other site 757424002597 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 757424002598 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 757424002599 transcription termination factor Rho; Provisional; Region: rho; PRK09376 757424002600 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 757424002601 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 757424002602 RNA binding site [nucleotide binding]; other site 757424002603 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 757424002604 multimer interface [polypeptide binding]; other site 757424002605 Walker A motif; other site 757424002606 ATP binding site [chemical binding]; other site 757424002607 Walker B motif; other site 757424002608 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 757424002609 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 757424002610 catalytic residues [active] 757424002611 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 757424002612 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 757424002613 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 757424002614 Family description; Region: UvrD_C_2; pfam13538 757424002615 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 757424002616 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 757424002617 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 757424002618 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 757424002619 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 757424002620 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 757424002621 HI0933-like protein; Region: HI0933_like; pfam03486 757424002622 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 757424002623 Yqey-like protein; Region: YqeY; pfam09424 757424002624 DNA primase; Validated; Region: dnaG; PRK05667 757424002625 CHC2 zinc finger; Region: zf-CHC2; pfam01807 757424002626 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 757424002627 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 757424002628 active site 757424002629 metal binding site [ion binding]; metal-binding site 757424002630 interdomain interaction site; other site 757424002631 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 757424002632 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 757424002633 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 757424002634 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 757424002635 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 757424002636 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 757424002637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424002638 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 757424002639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424002640 DNA binding residues [nucleotide binding] 757424002641 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 757424002642 integrase; Provisional; Region: int; PHA02601 757424002643 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 757424002644 active site 757424002645 DNA binding site [nucleotide binding] 757424002646 Int/Topo IB signature motif; other site 757424002647 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 757424002648 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 757424002649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424002650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424002651 non-specific DNA binding site [nucleotide binding]; other site 757424002652 salt bridge; other site 757424002653 sequence-specific DNA binding site [nucleotide binding]; other site 757424002654 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 757424002655 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 757424002656 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 757424002657 Phage-related tail protein [Function unknown]; Region: COG5283 757424002658 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 757424002659 Phage tail tube protein FII; Region: Phage_tube; pfam04985 757424002660 major tail sheath protein; Provisional; Region: FI; PHA02560 757424002661 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 757424002662 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 757424002663 Baseplate J-like protein; Region: Baseplate_J; cl01294 757424002664 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 757424002665 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 757424002666 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 757424002667 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 757424002668 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 757424002669 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 757424002670 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424002671 catalytic residue [active] 757424002672 Phage Tail Protein X; Region: Phage_tail_X; cl02088 757424002673 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 757424002674 terminase endonuclease subunit; Provisional; Region: M; PHA02537 757424002675 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 757424002676 capsid protein; Provisional; Region: N; PHA02538 757424002677 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 757424002678 terminase ATPase subunit; Provisional; Region: P; PHA02535 757424002679 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 757424002680 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 757424002681 portal vertex protein; Provisional; Region: Q; PHA02536 757424002682 Phage portal protein; Region: Phage_portal; pfam04860 757424002683 Response regulator receiver domain; Region: Response_reg; pfam00072 757424002684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424002685 active site 757424002686 phosphorylation site [posttranslational modification] 757424002687 intermolecular recognition site; other site 757424002688 dimerization interface [polypeptide binding]; other site 757424002689 Viral ankyrin protein; Provisional; Region: PHA02736 757424002690 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 757424002691 PAAR motif; Region: PAAR_motif; pfam05488 757424002692 Protein of unknown function DUF262; Region: DUF262; pfam03235 757424002693 Uncharacterized conserved protein [Function unknown]; Region: COG1479 757424002694 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 757424002695 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 757424002696 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424002697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424002698 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 757424002699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424002700 acyl-activating enzyme (AAE) consensus motif; other site 757424002701 AMP binding site [chemical binding]; other site 757424002702 active site 757424002703 CoA binding site [chemical binding]; other site 757424002704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 757424002705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424002706 NAD(P) binding site [chemical binding]; other site 757424002707 active site 757424002708 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 757424002709 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424002710 dimer interface [polypeptide binding]; other site 757424002711 active site 757424002712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424002713 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 757424002714 FAD binding site [chemical binding]; other site 757424002715 homotetramer interface [polypeptide binding]; other site 757424002716 substrate binding pocket [chemical binding]; other site 757424002717 catalytic base [active] 757424002718 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 757424002719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424002720 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 757424002721 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 757424002722 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 757424002723 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 757424002724 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 757424002725 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 757424002726 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 757424002727 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 757424002728 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 757424002729 amidase; Provisional; Region: PRK07235 757424002730 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 757424002731 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 757424002732 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 757424002733 heme-binding site [chemical binding]; other site 757424002734 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 757424002735 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424002736 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 757424002737 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 757424002738 active site 757424002739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424002740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424002741 2-isopropylmalate synthase; Validated; Region: PRK03739 757424002742 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 757424002743 active site 757424002744 catalytic residues [active] 757424002745 metal binding site [ion binding]; metal-binding site 757424002746 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 757424002747 Cupin domain; Region: Cupin_2; cl17218 757424002748 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424002749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424002750 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 757424002751 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424002752 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424002753 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424002754 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424002755 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 757424002756 NAD binding site [chemical binding]; other site 757424002757 PAAR motif; Region: PAAR_motif; pfam05488 757424002758 transcriptional regulator; Provisional; Region: PRK10632 757424002759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002760 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424002761 putative effector binding pocket; other site 757424002762 dimerization interface [polypeptide binding]; other site 757424002763 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 757424002764 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 757424002765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424002766 Zn2+ binding site [ion binding]; other site 757424002767 Mg2+ binding site [ion binding]; other site 757424002768 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 757424002769 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424002770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424002771 N-terminal plug; other site 757424002772 ligand-binding site [chemical binding]; other site 757424002773 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 757424002774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424002775 Walker A motif; other site 757424002776 ATP binding site [chemical binding]; other site 757424002777 Walker B motif; other site 757424002778 arginine finger; other site 757424002779 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 757424002780 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424002781 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424002782 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 757424002783 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 757424002784 active site 757424002785 dimer interface [polypeptide binding]; other site 757424002786 non-prolyl cis peptide bond; other site 757424002787 insertion regions; other site 757424002788 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424002789 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424002790 Walker A/P-loop; other site 757424002791 ATP binding site [chemical binding]; other site 757424002792 Q-loop/lid; other site 757424002793 ABC transporter signature motif; other site 757424002794 Walker B; other site 757424002795 D-loop; other site 757424002796 H-loop/switch region; other site 757424002797 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424002798 TM-ABC transporter signature motif; other site 757424002799 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424002800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424002801 TM-ABC transporter signature motif; other site 757424002802 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 757424002803 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424002804 putative ligand binding site [chemical binding]; other site 757424002805 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 757424002806 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 757424002807 Flavin binding site [chemical binding]; other site 757424002808 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424002809 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424002810 Walker A/P-loop; other site 757424002811 ATP binding site [chemical binding]; other site 757424002812 Q-loop/lid; other site 757424002813 ABC transporter signature motif; other site 757424002814 Walker B; other site 757424002815 D-loop; other site 757424002816 H-loop/switch region; other site 757424002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424002819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424002820 dimerization interface [polypeptide binding]; other site 757424002821 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 757424002822 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 757424002823 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424002824 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 757424002825 NAD(P) binding site [chemical binding]; other site 757424002826 catalytic residues [active] 757424002827 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 757424002828 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 757424002829 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 757424002830 transmembrane helices; other site 757424002831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424002832 non-specific DNA binding site [nucleotide binding]; other site 757424002833 salt bridge; other site 757424002834 sequence-specific DNA binding site [nucleotide binding]; other site 757424002835 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 757424002836 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 757424002837 NAD binding site [chemical binding]; other site 757424002838 substrate binding site [chemical binding]; other site 757424002839 catalytic Zn binding site [ion binding]; other site 757424002840 tetramer interface [polypeptide binding]; other site 757424002841 structural Zn binding site [ion binding]; other site 757424002842 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 757424002843 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 757424002844 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 757424002845 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 757424002846 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 757424002847 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 757424002848 Walker A/P-loop; other site 757424002849 ATP binding site [chemical binding]; other site 757424002850 Q-loop/lid; other site 757424002851 ABC transporter signature motif; other site 757424002852 Walker B; other site 757424002853 D-loop; other site 757424002854 H-loop/switch region; other site 757424002855 TOBE domain; Region: TOBE_2; pfam08402 757424002856 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 757424002857 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 757424002858 Walker A/P-loop; other site 757424002859 ATP binding site [chemical binding]; other site 757424002860 Q-loop/lid; other site 757424002861 ABC transporter signature motif; other site 757424002862 Walker B; other site 757424002863 D-loop; other site 757424002864 H-loop/switch region; other site 757424002865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424002866 dimer interface [polypeptide binding]; other site 757424002867 conserved gate region; other site 757424002868 putative PBP binding loops; other site 757424002869 ABC-ATPase subunit interface; other site 757424002870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424002871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424002872 dimer interface [polypeptide binding]; other site 757424002873 conserved gate region; other site 757424002874 putative PBP binding loops; other site 757424002875 ABC-ATPase subunit interface; other site 757424002876 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 757424002877 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424002878 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 757424002879 glycerol kinase; Provisional; Region: glpK; PRK00047 757424002880 N- and C-terminal domain interface [polypeptide binding]; other site 757424002881 active site 757424002882 MgATP binding site [chemical binding]; other site 757424002883 catalytic site [active] 757424002884 metal binding site [ion binding]; metal-binding site 757424002885 glycerol binding site [chemical binding]; other site 757424002886 homotetramer interface [polypeptide binding]; other site 757424002887 homodimer interface [polypeptide binding]; other site 757424002888 FBP binding site [chemical binding]; other site 757424002889 protein IIAGlc interface [polypeptide binding]; other site 757424002890 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 757424002891 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 757424002892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424002893 Zn2+ binding site [ion binding]; other site 757424002894 Mg2+ binding site [ion binding]; other site 757424002895 Cache domain; Region: Cache_1; pfam02743 757424002896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424002897 dimerization interface [polypeptide binding]; other site 757424002898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424002899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424002900 dimer interface [polypeptide binding]; other site 757424002901 putative CheW interface [polypeptide binding]; other site 757424002902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424002903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424002904 putative substrate translocation pore; other site 757424002905 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424002906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424002907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424002908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424002909 active site 757424002910 Acyltransferase family; Region: Acyl_transf_3; pfam01757 757424002911 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 757424002912 cysteine synthase B; Region: cysM; TIGR01138 757424002913 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 757424002914 dimer interface [polypeptide binding]; other site 757424002915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424002916 catalytic residue [active] 757424002917 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 757424002918 YaeQ protein; Region: YaeQ; pfam07152 757424002919 Phosphotransferase enzyme family; Region: APH; pfam01636 757424002920 serine/threonine protein kinase; Provisional; Region: PRK11768 757424002921 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424002922 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424002923 N-terminal plug; other site 757424002924 ligand-binding site [chemical binding]; other site 757424002925 Transglycosylase SLT domain; Region: SLT_2; pfam13406 757424002926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424002927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424002928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424002929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424002931 dimerization interface [polypeptide binding]; other site 757424002932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424002933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424002934 putative substrate translocation pore; other site 757424002935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424002936 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 757424002937 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 757424002938 GTP/Mg2+ binding site [chemical binding]; other site 757424002939 G4 box; other site 757424002940 G5 box; other site 757424002941 G1 box; other site 757424002942 Switch I region; other site 757424002943 G2 box; other site 757424002944 G3 box; other site 757424002945 Switch II region; other site 757424002946 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 757424002947 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 757424002948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424002949 dimer interface [polypeptide binding]; other site 757424002950 conserved gate region; other site 757424002951 ABC-ATPase subunit interface; other site 757424002952 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 757424002953 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 757424002954 Walker A/P-loop; other site 757424002955 ATP binding site [chemical binding]; other site 757424002956 Q-loop/lid; other site 757424002957 ABC transporter signature motif; other site 757424002958 Walker B; other site 757424002959 D-loop; other site 757424002960 H-loop/switch region; other site 757424002961 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 757424002962 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424002963 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424002964 trimer interface [polypeptide binding]; other site 757424002965 eyelet of channel; other site 757424002966 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 757424002967 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 757424002968 ring oligomerisation interface [polypeptide binding]; other site 757424002969 ATP/Mg binding site [chemical binding]; other site 757424002970 stacking interactions; other site 757424002971 hinge regions; other site 757424002972 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 757424002973 oligomerisation interface [polypeptide binding]; other site 757424002974 mobile loop; other site 757424002975 roof hairpin; other site 757424002976 Phage Tail Collar Domain; Region: Collar; pfam07484 757424002977 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 757424002978 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424002979 Sel1-like repeats; Region: SEL1; smart00671 757424002980 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 757424002981 haemagglutination activity domain; Region: Haemagg_act; smart00912 757424002982 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 757424002983 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 757424002984 Surface antigen; Region: Bac_surface_Ag; pfam01103 757424002985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424002986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424002987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424002988 dimerization interface [polypeptide binding]; other site 757424002989 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 757424002990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 757424002991 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 757424002992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424002993 putative active site [active] 757424002994 putative metal binding site [ion binding]; other site 757424002995 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 757424002996 iron-sulfur cluster [ion binding]; other site 757424002997 [2Fe-2S] cluster binding site [ion binding]; other site 757424002998 hypothetical protein; Provisional; Region: PRK06847 757424002999 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424003000 Putative cyclase; Region: Cyclase; pfam04199 757424003001 Cupin domain; Region: Cupin_2; pfam07883 757424003002 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 757424003003 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424003004 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424003005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003006 NAD(P) binding site [chemical binding]; other site 757424003007 active site 757424003008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424003009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424003010 metal binding site [ion binding]; metal-binding site 757424003011 active site 757424003012 I-site; other site 757424003013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003015 TM-ABC transporter signature motif; other site 757424003016 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424003017 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424003018 Walker A/P-loop; other site 757424003019 ATP binding site [chemical binding]; other site 757424003020 Q-loop/lid; other site 757424003021 ABC transporter signature motif; other site 757424003022 Walker B; other site 757424003023 D-loop; other site 757424003024 H-loop/switch region; other site 757424003025 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424003026 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 757424003027 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424003028 ligand binding site [chemical binding]; other site 757424003029 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003031 TM-ABC transporter signature motif; other site 757424003032 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 757424003033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424003034 substrate binding site [chemical binding]; other site 757424003035 dimer interface [polypeptide binding]; other site 757424003036 ATP binding site [chemical binding]; other site 757424003037 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 757424003038 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 757424003039 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424003040 NAD(P) binding site [chemical binding]; other site 757424003041 catalytic residues [active] 757424003042 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 757424003043 NAD(P) binding site [chemical binding]; other site 757424003044 catalytic residues [active] 757424003045 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 757424003046 intersubunit interface [polypeptide binding]; other site 757424003047 active site 757424003048 catalytic residue [active] 757424003049 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 757424003050 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 757424003051 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 757424003052 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 757424003053 active site 757424003054 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 757424003055 EamA-like transporter family; Region: EamA; pfam00892 757424003056 EamA-like transporter family; Region: EamA; pfam00892 757424003057 MarR family; Region: MarR_2; cl17246 757424003058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424003059 galactonate dehydratase; Provisional; Region: PRK14017 757424003060 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 757424003061 putative active site pocket [active] 757424003062 putative metal binding site [ion binding]; other site 757424003063 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 757424003064 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 757424003065 active site 757424003066 intersubunit interface [polypeptide binding]; other site 757424003067 catalytic residue [active] 757424003068 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 757424003069 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 757424003070 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 757424003071 active site 757424003072 catalytic residues [active] 757424003073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 757424003074 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 757424003075 putative ligand binding site [chemical binding]; other site 757424003076 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424003077 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424003078 Walker A/P-loop; other site 757424003079 ATP binding site [chemical binding]; other site 757424003080 Q-loop/lid; other site 757424003081 ABC transporter signature motif; other site 757424003082 Walker B; other site 757424003083 D-loop; other site 757424003084 H-loop/switch region; other site 757424003085 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424003086 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003087 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003088 TM-ABC transporter signature motif; other site 757424003089 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003090 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003091 TM-ABC transporter signature motif; other site 757424003092 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 757424003093 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 757424003094 putative ligand binding site [chemical binding]; other site 757424003095 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 757424003096 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424003097 Walker A/P-loop; other site 757424003098 ATP binding site [chemical binding]; other site 757424003099 Q-loop/lid; other site 757424003100 ABC transporter signature motif; other site 757424003101 Walker B; other site 757424003102 D-loop; other site 757424003103 H-loop/switch region; other site 757424003104 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424003105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003107 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003108 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003109 TM-ABC transporter signature motif; other site 757424003110 dihydroxy-acid dehydratase; Validated; Region: PRK06131 757424003111 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 757424003112 classical (c) SDRs; Region: SDR_c; cd05233 757424003113 NAD(P) binding site [chemical binding]; other site 757424003114 active site 757424003115 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 757424003116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003117 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 757424003118 putative dimerization interface [polypeptide binding]; other site 757424003119 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424003120 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424003121 trimer interface [polypeptide binding]; other site 757424003122 eyelet of channel; other site 757424003123 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 757424003124 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424003125 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424003126 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424003127 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 757424003128 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 757424003129 putative active site pocket [active] 757424003130 metal binding site [ion binding]; metal-binding site 757424003131 short chain dehydrogenase; Provisional; Region: PRK08628 757424003132 classical (c) SDRs; Region: SDR_c; cd05233 757424003133 NAD(P) binding site [chemical binding]; other site 757424003134 active site 757424003135 Domain of unknown function (DUF718); Region: DUF718; cl01281 757424003136 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424003137 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424003138 Walker A/P-loop; other site 757424003139 ATP binding site [chemical binding]; other site 757424003140 Q-loop/lid; other site 757424003141 ABC transporter signature motif; other site 757424003142 Walker B; other site 757424003143 D-loop; other site 757424003144 H-loop/switch region; other site 757424003145 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424003146 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003147 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003148 TM-ABC transporter signature motif; other site 757424003149 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 757424003150 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424003151 putative ligand binding site [chemical binding]; other site 757424003152 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 757424003153 Amidohydrolase; Region: Amidohydro_2; pfam04909 757424003154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424003155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424003156 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 757424003157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424003158 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 757424003159 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 757424003160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 757424003161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424003162 S-adenosylmethionine binding site [chemical binding]; other site 757424003163 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 757424003164 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 757424003165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003166 NAD(P) binding site [chemical binding]; other site 757424003167 active site 757424003168 SnoaL-like domain; Region: SnoaL_2; pfam12680 757424003169 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 757424003170 MgtC family; Region: MgtC; pfam02308 757424003171 Cupin domain; Region: Cupin_2; cl17218 757424003172 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424003173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424003174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424003175 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 757424003176 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424003177 putative ligand binding site [chemical binding]; other site 757424003178 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424003179 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424003180 Walker A/P-loop; other site 757424003181 ATP binding site [chemical binding]; other site 757424003182 Q-loop/lid; other site 757424003183 ABC transporter signature motif; other site 757424003184 Walker B; other site 757424003185 D-loop; other site 757424003186 H-loop/switch region; other site 757424003187 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424003188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003189 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424003190 TM-ABC transporter signature motif; other site 757424003191 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 757424003192 classical (c) SDRs; Region: SDR_c; cd05233 757424003193 NAD(P) binding site [chemical binding]; other site 757424003194 active site 757424003195 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 757424003196 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 757424003197 N- and C-terminal domain interface [polypeptide binding]; other site 757424003198 active site 757424003199 MgATP binding site [chemical binding]; other site 757424003200 catalytic site [active] 757424003201 metal binding site [ion binding]; metal-binding site 757424003202 carbohydrate binding site [chemical binding]; other site 757424003203 putative homodimer interface [polypeptide binding]; other site 757424003204 short chain dehydrogenase; Provisional; Region: PRK07060 757424003205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003206 NAD(P) binding site [chemical binding]; other site 757424003207 active site 757424003208 hypothetical protein; Provisional; Region: PRK06489 757424003209 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 757424003210 Cupin; Region: Cupin_6; pfam12852 757424003211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424003212 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424003213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424003214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424003215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003216 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424003217 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 757424003218 putative C-terminal domain interface [polypeptide binding]; other site 757424003219 putative GSH binding site (G-site) [chemical binding]; other site 757424003220 putative dimer interface [polypeptide binding]; other site 757424003221 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 757424003222 putative N-terminal domain interface [polypeptide binding]; other site 757424003223 putative dimer interface [polypeptide binding]; other site 757424003224 putative substrate binding pocket (H-site) [chemical binding]; other site 757424003225 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 757424003226 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 757424003227 transcriptional regulator; Provisional; Region: PRK10632 757424003228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003229 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 757424003230 putative effector binding pocket; other site 757424003231 putative dimerization interface [polypeptide binding]; other site 757424003232 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 757424003233 putative active site [active] 757424003234 succinic semialdehyde dehydrogenase; Region: PLN02278 757424003235 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 757424003236 tetramerization interface [polypeptide binding]; other site 757424003237 NAD(P) binding site [chemical binding]; other site 757424003238 catalytic residues [active] 757424003239 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 757424003240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003241 dimer interface [polypeptide binding]; other site 757424003242 conserved gate region; other site 757424003243 putative PBP binding loops; other site 757424003244 ABC-ATPase subunit interface; other site 757424003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003246 dimer interface [polypeptide binding]; other site 757424003247 conserved gate region; other site 757424003248 putative PBP binding loops; other site 757424003249 ABC-ATPase subunit interface; other site 757424003250 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 757424003251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424003252 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 757424003253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424003254 Walker A/P-loop; other site 757424003255 ATP binding site [chemical binding]; other site 757424003256 Q-loop/lid; other site 757424003257 ABC transporter signature motif; other site 757424003258 Walker B; other site 757424003259 D-loop; other site 757424003260 H-loop/switch region; other site 757424003261 TOBE domain; Region: TOBE_2; pfam08402 757424003262 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 757424003263 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424003264 inhibitor-cofactor binding pocket; inhibition site 757424003265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424003266 catalytic residue [active] 757424003267 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424003268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424003269 DNA-binding site [nucleotide binding]; DNA binding site 757424003270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424003271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424003272 homodimer interface [polypeptide binding]; other site 757424003273 catalytic residue [active] 757424003274 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 757424003275 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 757424003276 putative NAD(P) binding site [chemical binding]; other site 757424003277 dimer interface [polypeptide binding]; other site 757424003278 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 757424003279 Domain of unknown function DUF21; Region: DUF21; pfam01595 757424003280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 757424003281 Transporter associated domain; Region: CorC_HlyC; smart01091 757424003282 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424003283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424003284 non-specific DNA binding site [nucleotide binding]; other site 757424003285 salt bridge; other site 757424003286 sequence-specific DNA binding site [nucleotide binding]; other site 757424003287 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 757424003288 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 757424003289 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 757424003290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424003291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424003292 DNA binding site [nucleotide binding] 757424003293 domain linker motif; other site 757424003294 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 757424003295 putative dimerization interface [polypeptide binding]; other site 757424003296 putative ligand binding site [chemical binding]; other site 757424003297 GntP family permease; Region: GntP_permease; pfam02447 757424003298 fructuronate transporter; Provisional; Region: PRK10034; cl15264 757424003299 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 757424003300 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 757424003301 N- and C-terminal domain interface [polypeptide binding]; other site 757424003302 active site 757424003303 catalytic site [active] 757424003304 metal binding site [ion binding]; metal-binding site 757424003305 carbohydrate binding site [chemical binding]; other site 757424003306 ATP binding site [chemical binding]; other site 757424003307 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 757424003308 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 757424003309 NADP binding site [chemical binding]; other site 757424003310 homodimer interface [polypeptide binding]; other site 757424003311 active site 757424003312 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 757424003313 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 757424003314 putative NAD(P) binding site [chemical binding]; other site 757424003315 catalytic Zn binding site [ion binding]; other site 757424003316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003317 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424003318 dimer interface [polypeptide binding]; other site 757424003319 putative CheW interface [polypeptide binding]; other site 757424003320 transaldolase-like protein; Provisional; Region: PTZ00411 757424003321 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 757424003322 active site 757424003323 dimer interface [polypeptide binding]; other site 757424003324 catalytic residue [active] 757424003325 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 757424003326 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424003327 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424003328 putative active site [active] 757424003329 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 757424003330 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 757424003331 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 757424003332 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 757424003333 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 757424003334 active site 757424003335 dimer interface [polypeptide binding]; other site 757424003336 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 757424003337 dimer interface [polypeptide binding]; other site 757424003338 active site 757424003339 phosphogluconate dehydratase; Validated; Region: PRK09054 757424003340 6-phosphogluconate dehydratase; Region: edd; TIGR01196 757424003341 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 757424003342 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 757424003343 active site 757424003344 intersubunit interface [polypeptide binding]; other site 757424003345 catalytic residue [active] 757424003346 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 757424003347 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 757424003348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424003350 dimerization interface [polypeptide binding]; other site 757424003351 Cytochrome c; Region: Cytochrom_C; cl11414 757424003352 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 757424003353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 757424003354 PYR/PP interface [polypeptide binding]; other site 757424003355 dimer interface [polypeptide binding]; other site 757424003356 TPP binding site [chemical binding]; other site 757424003357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 757424003358 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 757424003359 TPP-binding site [chemical binding]; other site 757424003360 dimer interface [polypeptide binding]; other site 757424003361 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 757424003362 DctM-like transporters; Region: DctM; pfam06808 757424003363 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 757424003364 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 757424003365 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 757424003366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424003367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003368 NAD(P) binding site [chemical binding]; other site 757424003369 active site 757424003370 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424003371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003372 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424003373 dimerization interface [polypeptide binding]; other site 757424003374 substrate binding pocket [chemical binding]; other site 757424003375 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 757424003376 PLD-like domain; Region: PLDc_2; pfam13091 757424003377 putative active site [active] 757424003378 catalytic site [active] 757424003379 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 757424003380 PLD-like domain; Region: PLDc_2; pfam13091 757424003381 putative active site [active] 757424003382 catalytic site [active] 757424003383 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 757424003384 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 757424003385 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 757424003386 Flavodoxin; Region: Flavodoxin_1; pfam00258 757424003387 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 757424003388 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 757424003389 FAD binding pocket [chemical binding]; other site 757424003390 FAD binding motif [chemical binding]; other site 757424003391 catalytic residues [active] 757424003392 NAD binding pocket [chemical binding]; other site 757424003393 phosphate binding motif [ion binding]; other site 757424003394 beta-alpha-beta structure motif; other site 757424003395 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 757424003396 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 757424003397 nucleophilic elbow; other site 757424003398 catalytic triad; other site 757424003399 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 757424003400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003401 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 757424003402 substrate binding pocket [chemical binding]; other site 757424003403 dimerization interface [polypeptide binding]; other site 757424003404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003405 benzoate transport; Region: 2A0115; TIGR00895 757424003406 putative substrate translocation pore; other site 757424003407 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 757424003408 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 757424003409 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 757424003410 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424003411 maleylacetoacetate isomerase; Region: maiA; TIGR01262 757424003412 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 757424003413 C-terminal domain interface [polypeptide binding]; other site 757424003414 GSH binding site (G-site) [chemical binding]; other site 757424003415 putative dimer interface [polypeptide binding]; other site 757424003416 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 757424003417 dimer interface [polypeptide binding]; other site 757424003418 N-terminal domain interface [polypeptide binding]; other site 757424003419 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 757424003420 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 757424003421 putative active site [active] 757424003422 putative catalytic site [active] 757424003423 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 757424003424 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 757424003425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424003426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424003427 putative DNA binding site [nucleotide binding]; other site 757424003428 putative Zn2+ binding site [ion binding]; other site 757424003429 AsnC family; Region: AsnC_trans_reg; pfam01037 757424003430 hypothetical protein; Provisional; Region: PRK05965 757424003431 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424003432 inhibitor-cofactor binding pocket; inhibition site 757424003433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424003434 catalytic residue [active] 757424003435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 757424003436 succinic semialdehyde dehydrogenase; Region: PLN02278 757424003437 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 757424003438 tetramerization interface [polypeptide binding]; other site 757424003439 NAD(P) binding site [chemical binding]; other site 757424003440 catalytic residues [active] 757424003441 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 757424003442 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424003443 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 757424003444 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 757424003445 putative ligand binding site [chemical binding]; other site 757424003446 NAD binding site [chemical binding]; other site 757424003447 dimerization interface [polypeptide binding]; other site 757424003448 catalytic site [active] 757424003449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424003450 Coenzyme A binding pocket [chemical binding]; other site 757424003451 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 757424003452 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 757424003453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 757424003454 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 757424003455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 757424003456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003457 dimer interface [polypeptide binding]; other site 757424003458 conserved gate region; other site 757424003459 putative PBP binding loops; other site 757424003460 ABC-ATPase subunit interface; other site 757424003461 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 757424003462 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 757424003463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003464 dimer interface [polypeptide binding]; other site 757424003465 conserved gate region; other site 757424003466 ABC-ATPase subunit interface; other site 757424003467 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 757424003468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424003469 Walker A/P-loop; other site 757424003470 ATP binding site [chemical binding]; other site 757424003471 Q-loop/lid; other site 757424003472 ABC transporter signature motif; other site 757424003473 Walker B; other site 757424003474 D-loop; other site 757424003475 H-loop/switch region; other site 757424003476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424003477 Walker A/P-loop; other site 757424003478 ATP binding site [chemical binding]; other site 757424003479 Q-loop/lid; other site 757424003480 ABC transporter signature motif; other site 757424003481 Walker B; other site 757424003482 D-loop; other site 757424003483 H-loop/switch region; other site 757424003484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 757424003485 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 757424003486 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424003487 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424003488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424003490 dimerization interface [polypeptide binding]; other site 757424003491 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 757424003492 homotrimer interaction site [polypeptide binding]; other site 757424003493 putative active site [active] 757424003494 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 757424003495 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424003496 NAD binding site [chemical binding]; other site 757424003497 catalytic residues [active] 757424003498 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 757424003499 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 757424003500 metal binding site [ion binding]; metal-binding site 757424003501 putative dimer interface [polypeptide binding]; other site 757424003502 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 757424003503 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 757424003504 dimer interface [polypeptide binding]; other site 757424003505 active site 757424003506 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424003507 substrate binding site [chemical binding]; other site 757424003508 catalytic residue [active] 757424003509 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424003510 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424003511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424003512 dimerization interface [polypeptide binding]; other site 757424003513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003514 dimer interface [polypeptide binding]; other site 757424003515 putative CheW interface [polypeptide binding]; other site 757424003516 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 757424003517 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 757424003518 active site 757424003519 tetramer interface [polypeptide binding]; other site 757424003520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003521 D-galactonate transporter; Region: 2A0114; TIGR00893 757424003522 putative substrate translocation pore; other site 757424003523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424003524 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 757424003525 DNA-binding site [nucleotide binding]; DNA binding site 757424003526 FCD domain; Region: FCD; pfam07729 757424003527 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 757424003528 Malic enzyme, N-terminal domain; Region: malic; pfam00390 757424003529 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 757424003530 putative NAD(P) binding site [chemical binding]; other site 757424003531 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 757424003532 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 757424003533 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 757424003534 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424003535 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 757424003536 benzoate transport; Region: 2A0115; TIGR00895 757424003537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003538 putative substrate translocation pore; other site 757424003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003540 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 757424003541 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 757424003542 NAD(P) binding site [chemical binding]; other site 757424003543 catalytic residues [active] 757424003544 benzoylformate decarboxylase; Reviewed; Region: PRK07092 757424003545 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 757424003546 PYR/PP interface [polypeptide binding]; other site 757424003547 dimer interface [polypeptide binding]; other site 757424003548 TPP binding site [chemical binding]; other site 757424003549 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 757424003550 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 757424003551 TPP-binding site [chemical binding]; other site 757424003552 dimer interface [polypeptide binding]; other site 757424003553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424003554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003555 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 757424003556 putative dimerization interface [polypeptide binding]; other site 757424003557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424003558 MarR family; Region: MarR; pfam01047 757424003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424003561 putative substrate translocation pore; other site 757424003562 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 757424003563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424003564 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424003565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424003566 DNA binding site [nucleotide binding] 757424003567 domain linker motif; other site 757424003568 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 757424003569 putative ligand binding site [chemical binding]; other site 757424003570 putative dimerization interface [polypeptide binding]; other site 757424003571 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 757424003572 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 757424003573 active site 757424003574 tetramer interface [polypeptide binding]; other site 757424003575 D-galactonate transporter; Region: 2A0114; TIGR00893 757424003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003577 putative substrate translocation pore; other site 757424003578 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 757424003579 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 757424003580 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 757424003581 active site residue [active] 757424003582 OsmC-like protein; Region: OsmC; pfam02566 757424003583 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424003584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424003585 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424003586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424003587 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424003588 substrate binding pocket [chemical binding]; other site 757424003589 membrane-bound complex binding site; other site 757424003590 hinge residues; other site 757424003591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424003592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003593 dimer interface [polypeptide binding]; other site 757424003594 conserved gate region; other site 757424003595 putative PBP binding loops; other site 757424003596 ABC-ATPase subunit interface; other site 757424003597 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424003598 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424003599 Walker A/P-loop; other site 757424003600 ATP binding site [chemical binding]; other site 757424003601 Q-loop/lid; other site 757424003602 ABC transporter signature motif; other site 757424003603 Walker B; other site 757424003604 D-loop; other site 757424003605 H-loop/switch region; other site 757424003606 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 757424003607 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424003608 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 757424003609 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 757424003610 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 757424003611 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 757424003612 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 757424003613 generic binding surface II; other site 757424003614 generic binding surface I; other site 757424003615 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 757424003616 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424003617 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 757424003618 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 757424003619 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 757424003620 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 757424003621 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 757424003622 Ligand binding site; other site 757424003623 oligomer interface; other site 757424003624 adenylate kinase; Reviewed; Region: adk; PRK00279 757424003625 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 757424003626 AMP-binding site [chemical binding]; other site 757424003627 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 757424003628 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 757424003629 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 757424003630 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 757424003631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003632 NAD(P) binding site [chemical binding]; other site 757424003633 active site 757424003634 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 757424003635 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 757424003636 active site 757424003637 nucleophile elbow; other site 757424003638 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 757424003639 active site 757424003640 barstar interaction site; other site 757424003641 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 757424003642 putative RNAase interaction site [polypeptide binding]; other site 757424003643 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 757424003644 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 757424003645 active site 757424003646 substrate binding site [chemical binding]; other site 757424003647 cosubstrate binding site; other site 757424003648 catalytic site [active] 757424003649 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 757424003650 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 757424003651 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 757424003652 PLD-like domain; Region: PLDc_2; pfam13091 757424003653 putative active site [active] 757424003654 catalytic site [active] 757424003655 mechanosensitive channel MscS; Provisional; Region: PRK10334 757424003656 Mechanosensitive ion channel; Region: MS_channel; pfam00924 757424003657 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 757424003658 Fatty acid desaturase; Region: FA_desaturase; pfam00487 757424003659 Di-iron ligands [ion binding]; other site 757424003660 Transposase; Region: DDE_Tnp_ISL3; pfam01610 757424003661 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 757424003662 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 757424003663 hypothetical protein; Reviewed; Region: PRK00024 757424003664 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 757424003665 MPN+ (JAMM) motif; other site 757424003666 Zinc-binding site [ion binding]; other site 757424003667 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 757424003668 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 757424003669 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 757424003670 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 757424003671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424003672 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424003673 TM-ABC transporter signature motif; other site 757424003674 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424003675 TM-ABC transporter signature motif; other site 757424003676 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424003677 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424003678 Walker A/P-loop; other site 757424003679 ATP binding site [chemical binding]; other site 757424003680 Q-loop/lid; other site 757424003681 ABC transporter signature motif; other site 757424003682 Walker B; other site 757424003683 D-loop; other site 757424003684 H-loop/switch region; other site 757424003685 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424003686 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424003687 Walker A/P-loop; other site 757424003688 ATP binding site [chemical binding]; other site 757424003689 Q-loop/lid; other site 757424003690 ABC transporter signature motif; other site 757424003691 Walker B; other site 757424003692 D-loop; other site 757424003693 H-loop/switch region; other site 757424003694 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 757424003695 CsbD-like; Region: CsbD; pfam05532 757424003696 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 757424003697 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 757424003698 Ferritin-like domain; Region: Ferritin; pfam00210 757424003699 dinuclear metal binding motif [ion binding]; other site 757424003700 hypothetical protein; Provisional; Region: PRK10428 757424003701 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 757424003702 BON domain; Region: BON; pfam04972 757424003703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424003704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003705 active site 757424003706 phosphorylation site [posttranslational modification] 757424003707 intermolecular recognition site; other site 757424003708 dimerization interface [polypeptide binding]; other site 757424003709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424003710 DNA binding residues [nucleotide binding] 757424003711 dimerization interface [polypeptide binding]; other site 757424003712 Response regulator receiver domain; Region: Response_reg; pfam00072 757424003713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003714 active site 757424003715 phosphorylation site [posttranslational modification] 757424003716 intermolecular recognition site; other site 757424003717 PAS fold; Region: PAS_4; pfam08448 757424003718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424003719 putative active site [active] 757424003720 heme pocket [chemical binding]; other site 757424003721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 757424003722 Histidine kinase; Region: HisKA_3; pfam07730 757424003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424003724 ATP binding site [chemical binding]; other site 757424003725 Mg2+ binding site [ion binding]; other site 757424003726 G-X-G motif; other site 757424003727 CsbD-like; Region: CsbD; pfam05532 757424003728 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424003729 NMT1-like family; Region: NMT1_2; pfam13379 757424003730 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424003731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003732 dimer interface [polypeptide binding]; other site 757424003733 conserved gate region; other site 757424003734 putative PBP binding loops; other site 757424003735 ABC-ATPase subunit interface; other site 757424003736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424003737 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424003738 Walker A/P-loop; other site 757424003739 ATP binding site [chemical binding]; other site 757424003740 Q-loop/lid; other site 757424003741 ABC transporter signature motif; other site 757424003742 Walker B; other site 757424003743 D-loop; other site 757424003744 H-loop/switch region; other site 757424003745 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 757424003746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003747 putative CheW interface [polypeptide binding]; other site 757424003748 Protein of unknown function (DUF423); Region: DUF423; pfam04241 757424003749 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 757424003750 Mrr N-terminal domain; Region: Mrr_N; pfam14338 757424003751 Restriction endonuclease; Region: Mrr_cat; pfam04471 757424003752 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 757424003753 Tetratricopeptide repeat; Region: TPR_6; pfam13174 757424003754 translocation protein TolB; Provisional; Region: tolB; PRK02889 757424003755 TolB amino-terminal domain; Region: TolB_N; pfam04052 757424003756 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 757424003757 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 757424003758 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 757424003759 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 757424003760 TolA protein; Region: tolA_full; TIGR02794 757424003761 TonB C terminal; Region: TonB_2; pfam13103 757424003762 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424003763 TolR protein; Region: tolR; TIGR02801 757424003764 TolQ protein; Region: tolQ; TIGR02796 757424003765 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 757424003766 active site 757424003767 malonic semialdehyde reductase; Provisional; Region: PRK10538 757424003768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424003769 NAD(P) binding site [chemical binding]; other site 757424003770 active site 757424003771 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 757424003772 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 757424003773 dimer interface [polypeptide binding]; other site 757424003774 active site 757424003775 glycine-pyridoxal phosphate binding site [chemical binding]; other site 757424003776 folate binding site [chemical binding]; other site 757424003777 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 757424003778 ATP cone domain; Region: ATP-cone; pfam03477 757424003779 Cell division protein ZapA; Region: ZapA; pfam05164 757424003780 DTW domain; Region: DTW; cl01221 757424003781 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 757424003782 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 757424003783 generic binding surface II; other site 757424003784 ssDNA binding site; other site 757424003785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424003786 ATP binding site [chemical binding]; other site 757424003787 putative Mg++ binding site [ion binding]; other site 757424003788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424003789 nucleotide binding region [chemical binding]; other site 757424003790 ATP-binding site [chemical binding]; other site 757424003791 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 757424003792 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 757424003793 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 757424003794 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 757424003795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424003796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424003797 phosphorylation site [posttranslational modification] 757424003798 dimer interface [polypeptide binding]; other site 757424003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424003800 ATP binding site [chemical binding]; other site 757424003801 Mg2+ binding site [ion binding]; other site 757424003802 G-X-G motif; other site 757424003803 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424003804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003805 active site 757424003806 phosphorylation site [posttranslational modification] 757424003807 intermolecular recognition site; other site 757424003808 dimerization interface [polypeptide binding]; other site 757424003809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003811 active site 757424003812 phosphorylation site [posttranslational modification] 757424003813 intermolecular recognition site; other site 757424003814 dimerization interface [polypeptide binding]; other site 757424003815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424003816 DNA binding residues [nucleotide binding] 757424003817 HDOD domain; Region: HDOD; pfam08668 757424003818 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 757424003819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003820 active site 757424003821 phosphorylation site [posttranslational modification] 757424003822 intermolecular recognition site; other site 757424003823 dimerization interface [polypeptide binding]; other site 757424003824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424003825 Zn2+ binding site [ion binding]; other site 757424003826 Mg2+ binding site [ion binding]; other site 757424003827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424003828 dimer interface [polypeptide binding]; other site 757424003829 phosphorylation site [posttranslational modification] 757424003830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424003831 ATP binding site [chemical binding]; other site 757424003832 Mg2+ binding site [ion binding]; other site 757424003833 G-X-G motif; other site 757424003834 Response regulator receiver domain; Region: Response_reg; pfam00072 757424003835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003836 active site 757424003837 phosphorylation site [posttranslational modification] 757424003838 intermolecular recognition site; other site 757424003839 dimerization interface [polypeptide binding]; other site 757424003840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424003841 putative binding surface; other site 757424003842 active site 757424003843 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 757424003844 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 757424003845 Chromate transporter; Region: Chromate_transp; pfam02417 757424003846 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 757424003847 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 757424003848 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 757424003849 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 757424003850 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 757424003851 Protein export membrane protein; Region: SecD_SecF; pfam02355 757424003852 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 757424003853 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 757424003854 putative ATP binding site [chemical binding]; other site 757424003855 putative substrate interface [chemical binding]; other site 757424003856 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424003857 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 757424003858 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 757424003859 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 757424003860 dimer interface [polypeptide binding]; other site 757424003861 active site 757424003862 heme binding site [chemical binding]; other site 757424003863 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 757424003864 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 757424003865 Cupin domain; Region: Cupin_2; cl17218 757424003866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424003867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424003868 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424003869 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 757424003870 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 757424003871 active site 757424003872 substrate binding site [chemical binding]; other site 757424003873 Mg2+ binding site [ion binding]; other site 757424003874 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 757424003875 classical (c) SDRs; Region: SDR_c; cd05233 757424003876 NAD(P) binding site [chemical binding]; other site 757424003877 active site 757424003878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 757424003879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 757424003880 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 757424003881 putative active site [active] 757424003882 putative metal binding site [ion binding]; other site 757424003883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424003884 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 757424003885 HAMP domain; Region: HAMP; pfam00672 757424003886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003887 dimer interface [polypeptide binding]; other site 757424003888 putative CheW interface [polypeptide binding]; other site 757424003889 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424003890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424003891 dimerization interface [polypeptide binding]; other site 757424003892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003893 dimer interface [polypeptide binding]; other site 757424003894 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424003895 putative CheW interface [polypeptide binding]; other site 757424003896 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424003897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424003898 dimerization interface [polypeptide binding]; other site 757424003899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003900 dimer interface [polypeptide binding]; other site 757424003901 putative CheW interface [polypeptide binding]; other site 757424003902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 757424003903 catalytic core [active] 757424003904 polyphosphate kinase; Provisional; Region: PRK05443 757424003905 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 757424003906 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 757424003907 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 757424003908 putative active site [active] 757424003909 catalytic site [active] 757424003910 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 757424003911 putative domain interface [polypeptide binding]; other site 757424003912 putative active site [active] 757424003913 catalytic site [active] 757424003914 PBP superfamily domain; Region: PBP_like_2; cl17296 757424003915 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 757424003916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003917 dimer interface [polypeptide binding]; other site 757424003918 conserved gate region; other site 757424003919 putative PBP binding loops; other site 757424003920 ABC-ATPase subunit interface; other site 757424003921 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 757424003922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424003923 dimer interface [polypeptide binding]; other site 757424003924 conserved gate region; other site 757424003925 putative PBP binding loops; other site 757424003926 ABC-ATPase subunit interface; other site 757424003927 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 757424003928 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 757424003929 Walker A/P-loop; other site 757424003930 ATP binding site [chemical binding]; other site 757424003931 Q-loop/lid; other site 757424003932 ABC transporter signature motif; other site 757424003933 Walker B; other site 757424003934 D-loop; other site 757424003935 H-loop/switch region; other site 757424003936 transcriptional regulator PhoU; Provisional; Region: PRK11115 757424003937 PhoU domain; Region: PhoU; pfam01895 757424003938 PhoU domain; Region: PhoU; pfam01895 757424003939 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 757424003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424003941 active site 757424003942 phosphorylation site [posttranslational modification] 757424003943 intermolecular recognition site; other site 757424003944 dimerization interface [polypeptide binding]; other site 757424003945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424003946 DNA binding site [nucleotide binding] 757424003947 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 757424003948 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 757424003949 PAS domain; Region: PAS_8; pfam13188 757424003950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424003951 dimer interface [polypeptide binding]; other site 757424003952 phosphorylation site [posttranslational modification] 757424003953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424003954 ATP binding site [chemical binding]; other site 757424003955 Mg2+ binding site [ion binding]; other site 757424003956 G-X-G motif; other site 757424003957 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424003958 HAMP domain; Region: HAMP; pfam00672 757424003959 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424003960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424003961 dimer interface [polypeptide binding]; other site 757424003962 putative CheW interface [polypeptide binding]; other site 757424003963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424003964 classical (c) SDRs; Region: SDR_c; cd05233 757424003965 NAD(P) binding site [chemical binding]; other site 757424003966 active site 757424003967 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 757424003968 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424003969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424003970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424003971 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 757424003972 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 757424003973 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 757424003974 CoenzymeA binding site [chemical binding]; other site 757424003975 subunit interaction site [polypeptide binding]; other site 757424003976 PHB binding site; other site 757424003977 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 757424003978 CoA-transferase family III; Region: CoA_transf_3; pfam02515 757424003979 Helix-turn-helix domain; Region: HTH_17; pfam12728 757424003980 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 757424003981 dimer interface [polypeptide binding]; other site 757424003982 active site 757424003983 coenzyme A binding site [chemical binding]; other site 757424003984 citrylCoA binding site [chemical binding]; other site 757424003985 Citrate synthase; Region: Citrate_synt; pfam00285 757424003986 oxalacetate/citrate binding site [chemical binding]; other site 757424003987 catalytic triad [active] 757424003988 Predicted membrane protein [Function unknown]; Region: COG2510 757424003989 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 757424003990 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 757424003991 putative catalytic residue [active] 757424003992 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424003993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424003994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424003995 dimerization interface [polypeptide binding]; other site 757424003996 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 757424003997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424003998 putative substrate translocation pore; other site 757424003999 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 757424004000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424004001 N-terminal plug; other site 757424004002 ligand-binding site [chemical binding]; other site 757424004003 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424004004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424004005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424004006 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 757424004007 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 757424004008 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424004009 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424004010 trimer interface [polypeptide binding]; other site 757424004011 eyelet of channel; other site 757424004012 benzoate transport; Region: 2A0115; TIGR00895 757424004013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004014 putative substrate translocation pore; other site 757424004015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004016 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 757424004017 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 757424004018 inhibitor site; inhibition site 757424004019 active site 757424004020 dimer interface [polypeptide binding]; other site 757424004021 catalytic residue [active] 757424004022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424004025 dimerization interface [polypeptide binding]; other site 757424004026 FecR protein; Region: FecR; pfam04773 757424004027 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424004028 ligand binding site [chemical binding]; other site 757424004029 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424004030 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004031 dimer interface [polypeptide binding]; other site 757424004032 putative CheW interface [polypeptide binding]; other site 757424004033 transcriptional regulator; Provisional; Region: PRK10632 757424004034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004035 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424004036 putative effector binding pocket; other site 757424004037 dimerization interface [polypeptide binding]; other site 757424004038 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 757424004039 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 757424004040 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 757424004041 haemagglutination activity domain; Region: Haemagg_act; pfam05860 757424004042 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 757424004043 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424004044 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424004045 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424004046 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 757424004047 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 757424004048 DEAD/DEAH box helicase; Region: DEAD; pfam00270 757424004049 ATP binding site [chemical binding]; other site 757424004050 DEAD_2; Region: DEAD_2; pfam06733 757424004051 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 757424004052 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 757424004053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424004054 AAA domain; Region: AAA_21; pfam13304 757424004055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424004056 ABC transporter signature motif; other site 757424004057 Walker B; other site 757424004058 D-loop; other site 757424004059 H-loop/switch region; other site 757424004060 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424004061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004062 dimer interface [polypeptide binding]; other site 757424004063 putative CheW interface [polypeptide binding]; other site 757424004064 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 757424004065 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 757424004066 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 757424004067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004069 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 757424004070 dimerizarion interface [polypeptide binding]; other site 757424004071 CrgA pocket; other site 757424004072 substrate binding pocket [chemical binding]; other site 757424004073 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 757424004074 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 757424004075 octamer interface [polypeptide binding]; other site 757424004076 active site 757424004077 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 757424004078 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 757424004079 dimer interface [polypeptide binding]; other site 757424004080 active site 757424004081 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 757424004082 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 757424004083 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 757424004084 putative alpha subunit interface [polypeptide binding]; other site 757424004085 putative active site [active] 757424004086 putative substrate binding site [chemical binding]; other site 757424004087 Fe binding site [ion binding]; other site 757424004088 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 757424004089 inter-subunit interface; other site 757424004090 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 757424004091 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424004092 catalytic loop [active] 757424004093 iron binding site [ion binding]; other site 757424004094 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 757424004095 FAD binding pocket [chemical binding]; other site 757424004096 FAD binding motif [chemical binding]; other site 757424004097 phosphate binding motif [ion binding]; other site 757424004098 beta-alpha-beta structure motif; other site 757424004099 NAD binding pocket [chemical binding]; other site 757424004100 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 757424004101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424004102 NAD(P) binding site [chemical binding]; other site 757424004103 active site 757424004104 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 757424004105 homotrimer interaction site [polypeptide binding]; other site 757424004106 putative active site [active] 757424004107 benzoate transport; Region: 2A0115; TIGR00895 757424004108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004109 putative substrate translocation pore; other site 757424004110 Benzoate membrane transport protein; Region: BenE; pfam03594 757424004111 benzoate transporter; Region: benE; TIGR00843 757424004112 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 757424004113 G1 box; other site 757424004114 GTP/Mg2+ binding site [chemical binding]; other site 757424004115 G2 box; other site 757424004116 Switch I region; other site 757424004117 G3 box; other site 757424004118 Switch II region; other site 757424004119 G4 box; other site 757424004120 G5 box; other site 757424004121 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 757424004122 G1 box; other site 757424004123 GTP/Mg2+ binding site [chemical binding]; other site 757424004124 G2 box; other site 757424004125 Switch I region; other site 757424004126 G3 box; other site 757424004127 Switch II region; other site 757424004128 G4 box; other site 757424004129 G5 box; other site 757424004130 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 757424004131 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 757424004132 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 757424004133 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 757424004134 Moco binding site; other site 757424004135 metal coordination site [ion binding]; other site 757424004136 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424004137 Cytochrome c; Region: Cytochrom_C; pfam00034 757424004138 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 757424004139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424004140 catalytic loop [active] 757424004141 iron binding site [ion binding]; other site 757424004142 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 757424004143 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 757424004144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424004145 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 757424004146 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 757424004147 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 757424004148 Isochorismatase family; Region: Isochorismatase; pfam00857 757424004149 catalytic triad [active] 757424004150 substrate binding site [chemical binding]; other site 757424004151 domain interfaces; other site 757424004152 conserved cis-peptide bond; other site 757424004153 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 757424004154 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 757424004155 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 757424004156 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 757424004157 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 757424004158 Transcriptional regulators [Transcription]; Region: MarR; COG1846 757424004159 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 757424004160 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 757424004161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424004162 PAS domain; Region: PAS_9; pfam13426 757424004163 putative active site [active] 757424004164 heme pocket [chemical binding]; other site 757424004165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424004166 dimerization interface [polypeptide binding]; other site 757424004167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424004168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004169 dimer interface [polypeptide binding]; other site 757424004170 putative CheW interface [polypeptide binding]; other site 757424004171 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424004172 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424004173 trimer interface [polypeptide binding]; other site 757424004174 eyelet of channel; other site 757424004175 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 757424004176 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 757424004177 XdhC Rossmann domain; Region: XdhC_C; pfam13478 757424004178 FAD binding domain; Region: FAD_binding_3; pfam01494 757424004179 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424004180 benzoate transport; Region: 2A0115; TIGR00895 757424004181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004182 putative substrate translocation pore; other site 757424004183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004184 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 757424004185 Ligand binding site; other site 757424004186 metal-binding site 757424004187 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424004188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424004189 dimerization interface [polypeptide binding]; other site 757424004190 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004191 dimer interface [polypeptide binding]; other site 757424004192 putative CheW interface [polypeptide binding]; other site 757424004193 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 757424004194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004195 active site 757424004196 phosphorylation site [posttranslational modification] 757424004197 intermolecular recognition site; other site 757424004198 dimerization interface [polypeptide binding]; other site 757424004199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424004200 DNA binding residues [nucleotide binding] 757424004201 dimerization interface [polypeptide binding]; other site 757424004202 Flavin Reductases; Region: FlaRed; cl00801 757424004203 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 757424004204 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 757424004205 FMN-binding pocket [chemical binding]; other site 757424004206 flavin binding motif; other site 757424004207 phosphate binding motif [ion binding]; other site 757424004208 beta-alpha-beta structure motif; other site 757424004209 NAD binding pocket [chemical binding]; other site 757424004210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424004211 catalytic loop [active] 757424004212 iron binding site [ion binding]; other site 757424004213 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 757424004214 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 757424004215 [2Fe-2S] cluster binding site [ion binding]; other site 757424004216 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 757424004217 putative alpha subunit interface [polypeptide binding]; other site 757424004218 putative active site [active] 757424004219 putative substrate binding site [chemical binding]; other site 757424004220 Fe binding site [ion binding]; other site 757424004221 Amidase; Region: Amidase; cl11426 757424004222 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 757424004223 Amidase; Region: Amidase; cl11426 757424004224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004226 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 757424004227 substrate binding pocket [chemical binding]; other site 757424004228 dimerization interface [polypeptide binding]; other site 757424004229 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424004230 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424004231 trimer interface [polypeptide binding]; other site 757424004232 eyelet of channel; other site 757424004233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424004234 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 757424004235 putative active site [active] 757424004236 heme pocket [chemical binding]; other site 757424004237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424004238 putative active site [active] 757424004239 heme pocket [chemical binding]; other site 757424004240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424004241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424004242 dimer interface [polypeptide binding]; other site 757424004243 phosphorylation site [posttranslational modification] 757424004244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424004245 ATP binding site [chemical binding]; other site 757424004246 Mg2+ binding site [ion binding]; other site 757424004247 G-X-G motif; other site 757424004248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424004249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424004250 active site 757424004251 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424004252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424004253 NAD(P) binding site [chemical binding]; other site 757424004254 active site 757424004255 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 757424004256 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424004257 putative ligand binding site [chemical binding]; other site 757424004258 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424004259 TM-ABC transporter signature motif; other site 757424004260 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424004261 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424004262 TM-ABC transporter signature motif; other site 757424004263 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424004264 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424004265 Walker A/P-loop; other site 757424004266 ATP binding site [chemical binding]; other site 757424004267 Q-loop/lid; other site 757424004268 ABC transporter signature motif; other site 757424004269 Walker B; other site 757424004270 D-loop; other site 757424004271 H-loop/switch region; other site 757424004272 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424004273 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424004274 Walker A/P-loop; other site 757424004275 ATP binding site [chemical binding]; other site 757424004276 Q-loop/lid; other site 757424004277 ABC transporter signature motif; other site 757424004278 Walker B; other site 757424004279 D-loop; other site 757424004280 H-loop/switch region; other site 757424004281 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424004282 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 757424004283 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 757424004284 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 757424004285 intersubunit interface [polypeptide binding]; other site 757424004286 active site 757424004287 Zn2+ binding site [ion binding]; other site 757424004288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424004289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424004290 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 757424004291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424004292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424004293 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424004294 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 757424004295 Protein export membrane protein; Region: SecD_SecF; cl14618 757424004296 Protein export membrane protein; Region: SecD_SecF; cl14618 757424004297 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424004298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424004299 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424004300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424004301 dimerization interface [polypeptide binding]; other site 757424004302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004303 dimer interface [polypeptide binding]; other site 757424004304 putative CheW interface [polypeptide binding]; other site 757424004305 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 757424004306 DNA binding residues [nucleotide binding] 757424004307 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 757424004308 CHASE3 domain; Region: CHASE3; pfam05227 757424004309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004310 dimer interface [polypeptide binding]; other site 757424004311 putative CheW interface [polypeptide binding]; other site 757424004312 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424004313 GAF domain; Region: GAF; pfam01590 757424004314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424004315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424004316 metal binding site [ion binding]; metal-binding site 757424004317 active site 757424004318 I-site; other site 757424004319 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424004320 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 757424004321 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 757424004322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424004323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424004324 dimer interface [polypeptide binding]; other site 757424004325 phosphorylation site [posttranslational modification] 757424004326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424004327 ATP binding site [chemical binding]; other site 757424004328 Mg2+ binding site [ion binding]; other site 757424004329 G-X-G motif; other site 757424004330 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424004331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004332 active site 757424004333 phosphorylation site [posttranslational modification] 757424004334 intermolecular recognition site; other site 757424004335 dimerization interface [polypeptide binding]; other site 757424004336 Response regulator receiver domain; Region: Response_reg; pfam00072 757424004337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004338 active site 757424004339 phosphorylation site [posttranslational modification] 757424004340 intermolecular recognition site; other site 757424004341 dimerization interface [polypeptide binding]; other site 757424004342 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424004343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424004344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424004345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 757424004346 DNA binding site [nucleotide binding] 757424004347 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 757424004348 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 757424004349 inhibitor site; inhibition site 757424004350 active site 757424004351 dimer interface [polypeptide binding]; other site 757424004352 catalytic residue [active] 757424004353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424004356 dimerization interface [polypeptide binding]; other site 757424004357 transcriptional regulator NanR; Provisional; Region: PRK03837 757424004358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424004359 DNA-binding site [nucleotide binding]; DNA binding site 757424004360 FCD domain; Region: FCD; pfam07729 757424004361 Predicted transcriptional regulator [Transcription]; Region: COG2345 757424004362 Helix-turn-helix domain; Region: HTH_20; pfam12840 757424004363 putative DNA binding site [nucleotide binding]; other site 757424004364 putative Zn2+ binding site [ion binding]; other site 757424004365 Uncharacterized conserved protein [Function unknown]; Region: COG1739 757424004366 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 757424004367 hypothetical protein; Provisional; Region: PRK10279 757424004368 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 757424004369 nucleophile elbow; other site 757424004370 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 757424004371 NlpC/P60 family; Region: NLPC_P60; pfam00877 757424004372 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 757424004373 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 757424004374 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 757424004375 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 757424004376 catalytic site [active] 757424004377 subunit interface [polypeptide binding]; other site 757424004378 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 757424004379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424004380 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 757424004381 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 757424004382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424004383 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424004384 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 757424004385 IMP binding site; other site 757424004386 dimer interface [polypeptide binding]; other site 757424004387 interdomain contacts; other site 757424004388 partial ornithine binding site; other site 757424004389 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 757424004390 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 757424004391 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 757424004392 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 757424004393 FtsJ-like methyltransferase; Region: FtsJ; cl17430 757424004394 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 757424004395 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 757424004396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424004397 Walker A motif; other site 757424004398 ATP binding site [chemical binding]; other site 757424004399 Walker B motif; other site 757424004400 arginine finger; other site 757424004401 Peptidase family M41; Region: Peptidase_M41; pfam01434 757424004402 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 757424004403 dihydropteroate synthase; Region: DHPS; TIGR01496 757424004404 substrate binding pocket [chemical binding]; other site 757424004405 dimer interface [polypeptide binding]; other site 757424004406 inhibitor binding site; inhibition site 757424004407 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 757424004408 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 757424004409 active site 757424004410 substrate binding site [chemical binding]; other site 757424004411 metal binding site [ion binding]; metal-binding site 757424004412 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 757424004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004414 active site 757424004415 phosphorylation site [posttranslational modification] 757424004416 intermolecular recognition site; other site 757424004417 dimerization interface [polypeptide binding]; other site 757424004418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424004419 DNA binding site [nucleotide binding] 757424004420 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424004421 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424004422 Cytochrome c; Region: Cytochrom_C; pfam00034 757424004423 Cytochrome c553 [Energy production and conversion]; Region: COG2863 757424004424 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424004425 Cytochrome c; Region: Cytochrom_C; cl11414 757424004426 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 757424004427 Transglycosylase; Region: Transgly; pfam00912 757424004428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 757424004429 ABC transporter ATPase component; Reviewed; Region: PRK11147 757424004430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424004431 Walker A/P-loop; other site 757424004432 ATP binding site [chemical binding]; other site 757424004433 Q-loop/lid; other site 757424004434 ABC transporter signature motif; other site 757424004435 Walker B; other site 757424004436 D-loop; other site 757424004437 H-loop/switch region; other site 757424004438 ABC transporter; Region: ABC_tran_2; pfam12848 757424004439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424004440 Uncharacterized conserved protein [Function unknown]; Region: COG2912 757424004441 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 757424004442 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 757424004443 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 757424004444 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 757424004445 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 757424004446 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 757424004447 pseudouridine synthase; Region: TIGR00093 757424004448 active site 757424004449 isocitrate dehydrogenase; Validated; Region: PRK07362 757424004450 isocitrate dehydrogenase; Reviewed; Region: PRK07006 757424004451 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 757424004452 DNA-binding site [nucleotide binding]; DNA binding site 757424004453 RNA-binding motif; other site 757424004454 Uncharacterized conserved protein [Function unknown]; Region: COG2127 757424004455 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 757424004456 Clp amino terminal domain; Region: Clp_N; pfam02861 757424004457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424004458 Walker A motif; other site 757424004459 ATP binding site [chemical binding]; other site 757424004460 Walker B motif; other site 757424004461 arginine finger; other site 757424004462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424004463 Walker A motif; other site 757424004464 ATP binding site [chemical binding]; other site 757424004465 Walker B motif; other site 757424004466 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 757424004467 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 757424004468 Peptidase family M48; Region: Peptidase_M48; cl12018 757424004469 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 757424004470 trimer interface [polypeptide binding]; other site 757424004471 active site 757424004472 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 757424004473 Flavoprotein; Region: Flavoprotein; pfam02441 757424004474 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 757424004475 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 757424004476 lipoprotein signal peptidase; Provisional; Region: PRK14787 757424004477 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 757424004478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424004479 active site 757424004480 HIGH motif; other site 757424004481 nucleotide binding site [chemical binding]; other site 757424004482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 757424004483 active site 757424004484 KMSKS motif; other site 757424004485 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 757424004486 tRNA binding surface [nucleotide binding]; other site 757424004487 anticodon binding site; other site 757424004488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 757424004489 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 757424004490 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 757424004491 active site 757424004492 Riboflavin kinase; Region: Flavokinase; smart00904 757424004493 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424004494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424004495 DNA-binding site [nucleotide binding]; DNA binding site 757424004496 FCD domain; Region: FCD; pfam07729 757424004497 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 757424004498 Isochorismatase family; Region: Isochorismatase; pfam00857 757424004499 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 757424004500 catalytic triad [active] 757424004501 conserved cis-peptide bond; other site 757424004502 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 757424004503 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424004504 Walker A/P-loop; other site 757424004505 ATP binding site [chemical binding]; other site 757424004506 Q-loop/lid; other site 757424004507 ABC transporter signature motif; other site 757424004508 Walker B; other site 757424004509 D-loop; other site 757424004510 H-loop/switch region; other site 757424004511 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424004512 Isochorismatase family; Region: Isochorismatase; pfam00857 757424004513 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 757424004514 catalytic triad [active] 757424004515 conserved cis-peptide bond; other site 757424004516 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424004517 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 757424004518 TM-ABC transporter signature motif; other site 757424004519 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 757424004520 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 757424004521 putative ligand binding site [chemical binding]; other site 757424004522 allophanate hydrolase; Provisional; Region: PRK08186 757424004523 Amidase; Region: Amidase; cl11426 757424004524 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 757424004525 RNA methyltransferase, RsmE family; Region: TIGR00046 757424004526 transketolase; Reviewed; Region: PRK12753 757424004527 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 757424004528 TPP-binding site [chemical binding]; other site 757424004529 dimer interface [polypeptide binding]; other site 757424004530 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 757424004531 PYR/PP interface [polypeptide binding]; other site 757424004532 dimer interface [polypeptide binding]; other site 757424004533 TPP binding site [chemical binding]; other site 757424004534 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 757424004535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 757424004536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424004537 Coenzyme A binding pocket [chemical binding]; other site 757424004538 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 757424004539 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 757424004540 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 757424004541 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424004542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424004543 S-adenosylmethionine binding site [chemical binding]; other site 757424004544 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 757424004545 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 757424004546 metal binding triad; other site 757424004547 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 757424004548 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 757424004549 metal binding triad; other site 757424004550 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 757424004551 TIGR02099 family protein; Region: TIGR02099 757424004552 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 757424004553 nitrilase; Region: PLN02798 757424004554 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 757424004555 putative active site [active] 757424004556 catalytic triad [active] 757424004557 dimer interface [polypeptide binding]; other site 757424004558 protease TldD; Provisional; Region: tldD; PRK10735 757424004559 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 757424004560 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 757424004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 757424004562 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 757424004563 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 757424004564 FAD binding domain; Region: FAD_binding_4; pfam01565 757424004565 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 757424004566 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 757424004567 argininosuccinate synthase; Validated; Region: PRK05370 757424004568 argininosuccinate synthase; Provisional; Region: PRK13820 757424004569 ornithine carbamoyltransferase; Provisional; Region: PRK00779 757424004570 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 757424004571 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 757424004572 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 757424004573 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424004574 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 757424004575 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 757424004576 GTPase RsgA; Reviewed; Region: PRK00098 757424004577 RNA binding site [nucleotide binding]; other site 757424004578 homodimer interface [polypeptide binding]; other site 757424004579 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 757424004580 GTPase/Zn-binding domain interface [polypeptide binding]; other site 757424004581 GTP/Mg2+ binding site [chemical binding]; other site 757424004582 G4 box; other site 757424004583 G5 box; other site 757424004584 G1 box; other site 757424004585 Switch I region; other site 757424004586 G2 box; other site 757424004587 G3 box; other site 757424004588 Switch II region; other site 757424004589 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 757424004590 aromatic arch; other site 757424004591 DCoH dimer interaction site [polypeptide binding]; other site 757424004592 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 757424004593 DCoH tetramer interaction site [polypeptide binding]; other site 757424004594 substrate binding site [chemical binding]; other site 757424004595 Peptidase family M48; Region: Peptidase_M48; pfam01435 757424004596 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 757424004597 catalytic site [active] 757424004598 putative active site [active] 757424004599 putative substrate binding site [chemical binding]; other site 757424004600 dimer interface [polypeptide binding]; other site 757424004601 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 757424004602 serine/threonine protein kinase; Provisional; Region: PRK11768 757424004603 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 757424004604 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 757424004605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 757424004606 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 757424004607 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424004608 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 757424004609 tetramerization interface [polypeptide binding]; other site 757424004610 NAD(P) binding site [chemical binding]; other site 757424004611 catalytic residues [active] 757424004612 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 757424004613 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 757424004614 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 757424004615 putative molybdopterin cofactor binding site [chemical binding]; other site 757424004616 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 757424004617 putative molybdopterin cofactor binding site; other site 757424004618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424004619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424004620 non-specific DNA binding site [nucleotide binding]; other site 757424004621 salt bridge; other site 757424004622 sequence-specific DNA binding site [nucleotide binding]; other site 757424004623 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 757424004624 active site 757424004625 homodimer interface [polypeptide binding]; other site 757424004626 homotetramer interface [polypeptide binding]; other site 757424004627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424004628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424004629 metal binding site [ion binding]; metal-binding site 757424004630 active site 757424004631 I-site; other site 757424004632 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 757424004633 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 757424004634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424004635 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424004636 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 757424004637 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 757424004638 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 757424004639 active site 757424004640 Zn binding site [ion binding]; other site 757424004641 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 757424004642 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 757424004643 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 757424004644 homodimer interface [polypeptide binding]; other site 757424004645 NADP binding site [chemical binding]; other site 757424004646 substrate binding site [chemical binding]; other site 757424004647 glutamate--cysteine ligase; Provisional; Region: PRK02107 757424004648 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 757424004649 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 757424004650 dimer interface [polypeptide binding]; other site 757424004651 TPP-binding site [chemical binding]; other site 757424004652 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 757424004653 E3 interaction surface; other site 757424004654 lipoyl attachment site [posttranslational modification]; other site 757424004655 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 757424004656 E3 interaction surface; other site 757424004657 lipoyl attachment site [posttranslational modification]; other site 757424004658 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 757424004659 e3 binding domain; Region: E3_binding; pfam02817 757424004660 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 757424004661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 757424004662 E3 interaction surface; other site 757424004663 lipoyl attachment site [posttranslational modification]; other site 757424004664 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 757424004665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424004666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424004667 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 757424004668 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424004669 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424004670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004671 dimer interface [polypeptide binding]; other site 757424004672 putative CheW interface [polypeptide binding]; other site 757424004673 citrate-proton symporter; Provisional; Region: PRK15075 757424004674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004675 putative substrate translocation pore; other site 757424004676 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 757424004677 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424004678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004680 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 757424004681 putative dimerization interface [polypeptide binding]; other site 757424004682 PAAR motif; Region: PAAR_motif; pfam05488 757424004683 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 757424004684 tartrate dehydrogenase; Region: TTC; TIGR02089 757424004685 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 757424004686 active site 757424004687 phosphate binding residues; other site 757424004688 catalytic residues [active] 757424004689 transcriptional activator TtdR; Provisional; Region: PRK09801 757424004690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004691 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 757424004692 putative effector binding pocket; other site 757424004693 putative dimerization interface [polypeptide binding]; other site 757424004694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004695 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 757424004696 substrate binding pocket [chemical binding]; other site 757424004697 dimerization interface [polypeptide binding]; other site 757424004698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004699 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 757424004700 PBP superfamily domain; Region: PBP_like; pfam12727 757424004701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004702 putative substrate translocation pore; other site 757424004703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424004704 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 757424004705 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 757424004706 putative dimer interface [polypeptide binding]; other site 757424004707 [2Fe-2S] cluster binding site [ion binding]; other site 757424004708 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 757424004709 putative dimer interface [polypeptide binding]; other site 757424004710 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 757424004711 SLBB domain; Region: SLBB; pfam10531 757424004712 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 757424004713 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 757424004714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424004715 catalytic loop [active] 757424004716 iron binding site [ion binding]; other site 757424004717 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 757424004718 4Fe-4S binding domain; Region: Fer4; pfam00037 757424004719 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 757424004720 [4Fe-4S] binding site [ion binding]; other site 757424004721 molybdopterin cofactor binding site; other site 757424004722 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 757424004723 molybdopterin cofactor binding site; other site 757424004724 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 757424004725 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 757424004726 Flavin Reductases; Region: FlaRed; cl00801 757424004727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424004728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424004729 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 757424004730 substrate binding pocket [chemical binding]; other site 757424004731 dimerization interface [polypeptide binding]; other site 757424004732 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 757424004733 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 757424004734 putative NAD(P) binding site [chemical binding]; other site 757424004735 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 757424004736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424004737 SnoaL-like domain; Region: SnoaL_4; pfam13577 757424004738 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424004739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424004740 dimer interface [polypeptide binding]; other site 757424004741 conserved gate region; other site 757424004742 putative PBP binding loops; other site 757424004743 ABC-ATPase subunit interface; other site 757424004744 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424004745 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424004746 Walker A/P-loop; other site 757424004747 ATP binding site [chemical binding]; other site 757424004748 Q-loop/lid; other site 757424004749 ABC transporter signature motif; other site 757424004750 Walker B; other site 757424004751 D-loop; other site 757424004752 H-loop/switch region; other site 757424004753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424004754 substrate binding pocket [chemical binding]; other site 757424004755 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424004756 membrane-bound complex binding site; other site 757424004757 hinge residues; other site 757424004758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424004759 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424004760 active site 757424004761 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424004762 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424004763 N-terminal plug; other site 757424004764 ligand-binding site [chemical binding]; other site 757424004765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424004766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424004767 DNA binding site [nucleotide binding] 757424004768 domain linker motif; other site 757424004769 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 757424004770 putative dimerization interface [polypeptide binding]; other site 757424004771 putative ligand binding site [chemical binding]; other site 757424004772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424004773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424004774 substrate binding pocket [chemical binding]; other site 757424004775 membrane-bound complex binding site; other site 757424004776 hinge residues; other site 757424004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424004778 dimer interface [polypeptide binding]; other site 757424004779 conserved gate region; other site 757424004780 ABC-ATPase subunit interface; other site 757424004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424004782 dimer interface [polypeptide binding]; other site 757424004783 conserved gate region; other site 757424004784 putative PBP binding loops; other site 757424004785 ABC-ATPase subunit interface; other site 757424004786 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424004787 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424004788 Walker A/P-loop; other site 757424004789 ATP binding site [chemical binding]; other site 757424004790 Q-loop/lid; other site 757424004791 ABC transporter signature motif; other site 757424004792 Walker B; other site 757424004793 D-loop; other site 757424004794 H-loop/switch region; other site 757424004795 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 757424004796 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424004797 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 757424004798 substrate binding site [chemical binding]; other site 757424004799 ATP binding site [chemical binding]; other site 757424004800 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 757424004801 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 757424004802 dimerization interface [polypeptide binding]; other site 757424004803 ligand binding site [chemical binding]; other site 757424004804 NADP binding site [chemical binding]; other site 757424004805 catalytic site [active] 757424004806 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 757424004807 Ligand binding site [chemical binding]; other site 757424004808 Electron transfer flavoprotein domain; Region: ETF; pfam01012 757424004809 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 757424004810 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 757424004811 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 757424004812 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 757424004813 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 757424004814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424004815 active site 757424004816 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 757424004817 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 757424004818 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 757424004819 RimM N-terminal domain; Region: RimM; pfam01782 757424004820 PRC-barrel domain; Region: PRC; pfam05239 757424004821 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 757424004822 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 757424004823 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 757424004824 putative active site [active] 757424004825 putative CoA binding site [chemical binding]; other site 757424004826 nudix motif; other site 757424004827 metal binding site [ion binding]; metal-binding site 757424004828 CobD/CbiB family protein; Provisional; Region: PRK07630 757424004829 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 757424004830 fumarate hydratase; Reviewed; Region: fumC; PRK00485 757424004831 Class II fumarases; Region: Fumarase_classII; cd01362 757424004832 active site 757424004833 tetramer interface [polypeptide binding]; other site 757424004834 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 757424004835 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 757424004836 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 757424004837 active site 757424004838 HIGH motif; other site 757424004839 dimer interface [polypeptide binding]; other site 757424004840 KMSKS motif; other site 757424004841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424004842 dimerization interface [polypeptide binding]; other site 757424004843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424004844 ATP binding site [chemical binding]; other site 757424004845 Mg2+ binding site [ion binding]; other site 757424004846 G-X-G motif; other site 757424004847 osmolarity response regulator; Provisional; Region: ompR; PRK09468 757424004848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004849 active site 757424004850 phosphorylation site [posttranslational modification] 757424004851 intermolecular recognition site; other site 757424004852 dimerization interface [polypeptide binding]; other site 757424004853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424004854 DNA binding site [nucleotide binding] 757424004855 LTXXQ motif family protein; Region: LTXXQ; pfam07813 757424004856 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424004857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424004858 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424004859 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 757424004860 Protein export membrane protein; Region: SecD_SecF; cl14618 757424004861 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 757424004862 Protein export membrane protein; Region: SecD_SecF; cl14618 757424004863 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424004864 aminodeoxychorismate synthase; Provisional; Region: PRK07508 757424004865 chorismate binding enzyme; Region: Chorismate_bind; cl10555 757424004866 hypothetical protein; Provisional; Region: PRK07546 757424004867 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 757424004868 homodimer interface [polypeptide binding]; other site 757424004869 substrate-cofactor binding pocket; other site 757424004870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424004871 catalytic residue [active] 757424004872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424004874 putative substrate translocation pore; other site 757424004875 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424004876 EamA-like transporter family; Region: EamA; pfam00892 757424004877 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 757424004878 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 757424004879 oligomer interface [polypeptide binding]; other site 757424004880 metal binding site [ion binding]; metal-binding site 757424004881 metal binding site [ion binding]; metal-binding site 757424004882 putative Cl binding site [ion binding]; other site 757424004883 basic sphincter; other site 757424004884 hydrophobic gate; other site 757424004885 periplasmic entrance; other site 757424004886 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424004887 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424004888 N-terminal plug; other site 757424004889 ligand-binding site [chemical binding]; other site 757424004890 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 757424004891 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 757424004892 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 757424004893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 757424004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 757424004895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 757424004896 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 757424004897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424004898 Walker A/P-loop; other site 757424004899 ATP binding site [chemical binding]; other site 757424004900 Q-loop/lid; other site 757424004901 ABC transporter signature motif; other site 757424004902 Walker B; other site 757424004903 D-loop; other site 757424004904 H-loop/switch region; other site 757424004905 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424004906 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424004907 Walker A/P-loop; other site 757424004908 ATP binding site [chemical binding]; other site 757424004909 Q-loop/lid; other site 757424004910 ABC transporter signature motif; other site 757424004911 Walker B; other site 757424004912 D-loop; other site 757424004913 H-loop/switch region; other site 757424004914 Cache domain; Region: Cache_1; pfam02743 757424004915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424004916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424004917 metal binding site [ion binding]; metal-binding site 757424004918 active site 757424004919 I-site; other site 757424004920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 757424004921 Family of unknown function (DUF490); Region: DUF490; pfam04357 757424004922 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 757424004923 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424004924 Surface antigen; Region: Bac_surface_Ag; pfam01103 757424004925 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 757424004926 ferredoxin-NADP reductase; Provisional; Region: PRK10926 757424004927 FAD binding pocket [chemical binding]; other site 757424004928 FAD binding motif [chemical binding]; other site 757424004929 phosphate binding motif [ion binding]; other site 757424004930 beta-alpha-beta structure motif; other site 757424004931 NAD binding pocket [chemical binding]; other site 757424004932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424004933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004934 active site 757424004935 phosphorylation site [posttranslational modification] 757424004936 intermolecular recognition site; other site 757424004937 dimerization interface [polypeptide binding]; other site 757424004938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424004939 DNA binding residues [nucleotide binding] 757424004940 dimerization interface [polypeptide binding]; other site 757424004941 Predicted transcriptional regulators [Transcription]; Region: COG1733 757424004942 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 757424004943 glutathionine S-transferase; Provisional; Region: PRK10542 757424004944 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 757424004945 C-terminal domain interface [polypeptide binding]; other site 757424004946 GSH binding site (G-site) [chemical binding]; other site 757424004947 dimer interface [polypeptide binding]; other site 757424004948 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 757424004949 dimer interface [polypeptide binding]; other site 757424004950 N-terminal domain interface [polypeptide binding]; other site 757424004951 substrate binding pocket (H-site) [chemical binding]; other site 757424004952 glutamate racemase; Provisional; Region: PRK00865 757424004953 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 757424004954 Fumarase C-terminus; Region: Fumerase_C; pfam05683 757424004955 hypothetical protein; Provisional; Region: PRK05208 757424004956 acetyl-CoA synthetase; Provisional; Region: PRK00174 757424004957 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 757424004958 active site 757424004959 CoA binding site [chemical binding]; other site 757424004960 acyl-activating enzyme (AAE) consensus motif; other site 757424004961 AMP binding site [chemical binding]; other site 757424004962 acetate binding site [chemical binding]; other site 757424004963 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 757424004964 MarR family; Region: MarR_2; cl17246 757424004965 Transcriptional regulators [Transcription]; Region: MarR; COG1846 757424004966 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 757424004967 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424004968 Zn binding site [ion binding]; other site 757424004969 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 757424004970 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424004971 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 757424004972 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 757424004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424004974 active site 757424004975 phosphorylation site [posttranslational modification] 757424004976 intermolecular recognition site; other site 757424004977 dimerization interface [polypeptide binding]; other site 757424004978 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424004979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424004980 dimerization interface [polypeptide binding]; other site 757424004981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424004982 dimer interface [polypeptide binding]; other site 757424004983 putative CheW interface [polypeptide binding]; other site 757424004984 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424004985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424004986 substrate binding pocket [chemical binding]; other site 757424004987 membrane-bound complex binding site; other site 757424004988 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 757424004989 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 757424004990 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 757424004991 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 757424004992 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 757424004993 Walker A/P-loop; other site 757424004994 ATP binding site [chemical binding]; other site 757424004995 Q-loop/lid; other site 757424004996 ABC transporter signature motif; other site 757424004997 Walker B; other site 757424004998 D-loop; other site 757424004999 H-loop/switch region; other site 757424005000 NIL domain; Region: NIL; pfam09383 757424005001 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 757424005002 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 757424005003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424005004 catalytic residue [active] 757424005005 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 757424005006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424005008 dimerization interface [polypeptide binding]; other site 757424005009 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 757424005010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424005011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424005012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 757424005013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005014 dimer interface [polypeptide binding]; other site 757424005015 conserved gate region; other site 757424005016 putative PBP binding loops; other site 757424005017 ABC-ATPase subunit interface; other site 757424005018 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 757424005019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005020 dimer interface [polypeptide binding]; other site 757424005021 conserved gate region; other site 757424005022 putative PBP binding loops; other site 757424005023 ABC-ATPase subunit interface; other site 757424005024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 757424005025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424005026 Walker A/P-loop; other site 757424005027 ATP binding site [chemical binding]; other site 757424005028 Q-loop/lid; other site 757424005029 ABC transporter signature motif; other site 757424005030 Walker B; other site 757424005031 D-loop; other site 757424005032 H-loop/switch region; other site 757424005033 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424005034 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 757424005035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424005036 Walker A/P-loop; other site 757424005037 ATP binding site [chemical binding]; other site 757424005038 Q-loop/lid; other site 757424005039 ABC transporter signature motif; other site 757424005040 Walker B; other site 757424005041 D-loop; other site 757424005042 H-loop/switch region; other site 757424005043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 757424005044 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 757424005045 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 757424005046 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 757424005047 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 757424005048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 757424005049 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 757424005050 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 757424005051 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 757424005052 lipoyl attachment site [posttranslational modification]; other site 757424005053 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 757424005054 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 757424005055 active site 757424005056 dimer interface [polypeptide binding]; other site 757424005057 non-prolyl cis peptide bond; other site 757424005058 insertion regions; other site 757424005059 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424005060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005061 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424005062 dimerization interface [polypeptide binding]; other site 757424005063 substrate binding pocket [chemical binding]; other site 757424005064 serine O-acetyltransferase; Region: cysE; TIGR01172 757424005065 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 757424005066 trimer interface [polypeptide binding]; other site 757424005067 active site 757424005068 substrate binding site [chemical binding]; other site 757424005069 CoA binding site [chemical binding]; other site 757424005070 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 757424005071 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 757424005072 Cl- selectivity filter; other site 757424005073 Cl- binding residues [ion binding]; other site 757424005074 pore gating glutamate residue; other site 757424005075 dimer interface [polypeptide binding]; other site 757424005076 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 757424005077 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424005078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424005079 substrate binding pocket [chemical binding]; other site 757424005080 membrane-bound complex binding site; other site 757424005081 hinge residues; other site 757424005082 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 757424005083 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 757424005084 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 757424005085 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 757424005086 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 757424005087 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 757424005088 putative active site [active] 757424005089 putative substrate binding site [chemical binding]; other site 757424005090 putative cosubstrate binding site; other site 757424005091 catalytic site [active] 757424005092 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 757424005093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424005094 acyl-activating enzyme (AAE) consensus motif; other site 757424005095 AMP binding site [chemical binding]; other site 757424005096 active site 757424005097 CoA binding site [chemical binding]; other site 757424005098 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 757424005099 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 757424005100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 757424005101 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 757424005102 Outer membrane efflux protein; Region: OEP; pfam02321 757424005103 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 757424005104 Heavy-metal-associated domain; Region: HMA; pfam00403 757424005105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424005106 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 757424005107 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 757424005108 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 757424005109 DNA binding residues [nucleotide binding] 757424005110 dimer interface [polypeptide binding]; other site 757424005111 putative metal binding site [ion binding]; other site 757424005112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 757424005113 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 757424005114 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 757424005115 DNA binding residues [nucleotide binding] 757424005116 dimer interface [polypeptide binding]; other site 757424005117 copper binding site [ion binding]; other site 757424005118 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 757424005119 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 757424005120 metal-binding site [ion binding] 757424005121 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424005122 Soluble P-type ATPase [General function prediction only]; Region: COG4087 757424005123 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 757424005124 metal-binding site [ion binding] 757424005125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 757424005126 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 757424005127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 757424005128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 757424005129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424005130 Walker A motif; other site 757424005131 ATP binding site [chemical binding]; other site 757424005132 Walker B motif; other site 757424005133 arginine finger; other site 757424005134 Site-specific recombinase; Region: SpecificRecomb; cl15411 757424005135 Cytochrome c553 [Energy production and conversion]; Region: COG2863 757424005136 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424005137 Cytochrome c553 [Energy production and conversion]; Region: COG2863 757424005138 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 757424005139 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424005140 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 757424005141 dimerization interface [polypeptide binding]; other site 757424005142 ligand binding site [chemical binding]; other site 757424005143 endonuclease III; Provisional; Region: PRK10702 757424005144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 757424005145 minor groove reading motif; other site 757424005146 helix-hairpin-helix signature motif; other site 757424005147 substrate binding pocket [chemical binding]; other site 757424005148 active site 757424005149 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 757424005150 ferredoxin; Provisional; Region: PRK08764 757424005151 Putative Fe-S cluster; Region: FeS; pfam04060 757424005152 4Fe-4S binding domain; Region: Fer4; pfam00037 757424005153 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 757424005154 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 757424005155 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 757424005156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424005157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424005158 Ferredoxin [Energy production and conversion]; Region: COG1146 757424005159 4Fe-4S binding domain; Region: Fer4; pfam00037 757424005160 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 757424005161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424005162 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424005163 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 757424005164 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 757424005165 active site 757424005166 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 757424005167 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 757424005168 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 757424005169 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 757424005170 dimerization interface [polypeptide binding]; other site 757424005171 ligand binding site [chemical binding]; other site 757424005172 NADP binding site [chemical binding]; other site 757424005173 catalytic site [active] 757424005174 Acyl CoA binding protein; Region: ACBP; pfam00887 757424005175 acyl-CoA binding pocket [chemical binding]; other site 757424005176 CoA binding site [chemical binding]; other site 757424005177 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 757424005178 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 757424005179 Uncharacterized conserved protein [Function unknown]; Region: COG3391 757424005180 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 757424005181 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 757424005182 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 757424005183 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 757424005184 NodB motif; other site 757424005185 active site 757424005186 catalytic site [active] 757424005187 metal binding site [ion binding]; metal-binding site 757424005188 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 757424005189 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 757424005190 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 757424005191 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 757424005192 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 757424005193 putative MPT binding site; other site 757424005194 Phasin protein; Region: Phasin_2; pfam09361 757424005195 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 757424005196 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 757424005197 putative active site [active] 757424005198 Zn binding site [ion binding]; other site 757424005199 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 757424005200 EamA-like transporter family; Region: EamA; pfam00892 757424005201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424005202 salt bridge; other site 757424005203 non-specific DNA binding site [nucleotide binding]; other site 757424005204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424005205 sequence-specific DNA binding site [nucleotide binding]; other site 757424005206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 757424005207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424005208 S-adenosylmethionine binding site [chemical binding]; other site 757424005209 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 757424005210 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 757424005211 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424005212 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424005213 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424005214 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 757424005215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424005216 substrate binding pocket [chemical binding]; other site 757424005217 membrane-bound complex binding site; other site 757424005218 hinge residues; other site 757424005219 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424005220 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 757424005221 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424005222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424005223 substrate binding pocket [chemical binding]; other site 757424005224 membrane-bound complex binding site; other site 757424005225 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 757424005226 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 757424005227 active site 757424005228 dimer interface [polypeptide binding]; other site 757424005229 non-prolyl cis peptide bond; other site 757424005230 insertion regions; other site 757424005231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424005232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005233 putative PBP binding loops; other site 757424005234 dimer interface [polypeptide binding]; other site 757424005235 ABC-ATPase subunit interface; other site 757424005236 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424005237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424005238 Walker A/P-loop; other site 757424005239 ATP binding site [chemical binding]; other site 757424005240 Q-loop/lid; other site 757424005241 ABC transporter signature motif; other site 757424005242 Walker B; other site 757424005243 D-loop; other site 757424005244 H-loop/switch region; other site 757424005245 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 757424005246 EAL domain; Region: EAL; pfam00563 757424005247 Serine hydrolase; Region: Ser_hydrolase; pfam06821 757424005248 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 757424005249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005250 dimer interface [polypeptide binding]; other site 757424005251 conserved gate region; other site 757424005252 putative PBP binding loops; other site 757424005253 ABC-ATPase subunit interface; other site 757424005254 sulfate transport protein; Provisional; Region: cysT; CHL00187 757424005255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005256 dimer interface [polypeptide binding]; other site 757424005257 conserved gate region; other site 757424005258 putative PBP binding loops; other site 757424005259 ABC-ATPase subunit interface; other site 757424005260 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 757424005261 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 757424005262 Walker A/P-loop; other site 757424005263 ATP binding site [chemical binding]; other site 757424005264 Q-loop/lid; other site 757424005265 ABC transporter signature motif; other site 757424005266 Walker B; other site 757424005267 D-loop; other site 757424005268 H-loop/switch region; other site 757424005269 TOBE-like domain; Region: TOBE_3; pfam12857 757424005270 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 757424005271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005272 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 757424005273 substrate binding site [chemical binding]; other site 757424005274 dimerization interface [polypeptide binding]; other site 757424005275 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 757424005276 Predicted periplasmic protein [Function unknown]; Region: COG3698 757424005277 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 757424005278 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424005279 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 757424005280 dimerization interface [polypeptide binding]; other site 757424005281 ligand binding site [chemical binding]; other site 757424005282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424005283 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424005284 TM-ABC transporter signature motif; other site 757424005285 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 757424005286 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424005287 TM-ABC transporter signature motif; other site 757424005288 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 757424005289 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424005290 Walker A/P-loop; other site 757424005291 ATP binding site [chemical binding]; other site 757424005292 Q-loop/lid; other site 757424005293 ABC transporter signature motif; other site 757424005294 Walker B; other site 757424005295 D-loop; other site 757424005296 H-loop/switch region; other site 757424005297 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424005298 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424005299 Walker A/P-loop; other site 757424005300 ATP binding site [chemical binding]; other site 757424005301 Q-loop/lid; other site 757424005302 ABC transporter signature motif; other site 757424005303 Walker B; other site 757424005304 D-loop; other site 757424005305 H-loop/switch region; other site 757424005306 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 757424005307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424005308 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 757424005309 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 757424005310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424005311 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424005312 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424005313 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424005314 Cytochrome c; Region: Cytochrom_C; pfam00034 757424005315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424005316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424005317 substrate binding pocket [chemical binding]; other site 757424005318 membrane-bound complex binding site; other site 757424005319 hinge residues; other site 757424005320 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 757424005321 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 757424005322 dimer interface [polypeptide binding]; other site 757424005323 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 757424005324 active site 757424005325 Fe binding site [ion binding]; other site 757424005326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424005327 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 757424005328 putative DNA binding site [nucleotide binding]; other site 757424005329 putative Zn2+ binding site [ion binding]; other site 757424005330 AsnC family; Region: AsnC_trans_reg; pfam01037 757424005331 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 757424005332 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 757424005333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424005334 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 757424005335 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 757424005336 DNA binding site [nucleotide binding] 757424005337 active site 757424005338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 757424005339 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 757424005340 substrate binding pocket [chemical binding]; other site 757424005341 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 757424005342 nucleophile elbow; other site 757424005343 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 757424005344 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424005345 EamA-like transporter family; Region: EamA; pfam00892 757424005346 EamA-like transporter family; Region: EamA; pfam00892 757424005347 Cupin domain; Region: Cupin_2; cl17218 757424005348 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424005349 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424005350 dimer interface [polypeptide binding]; other site 757424005351 putative CheW interface [polypeptide binding]; other site 757424005352 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 757424005353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424005354 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 757424005355 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 757424005356 putative DNA binding site [nucleotide binding]; other site 757424005357 putative Zn2+ binding site [ion binding]; other site 757424005358 AsnC family; Region: AsnC_trans_reg; pfam01037 757424005359 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 757424005360 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 757424005361 putative molybdopterin cofactor binding site [chemical binding]; other site 757424005362 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 757424005363 putative molybdopterin cofactor binding site; other site 757424005364 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424005365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424005366 DNA-binding site [nucleotide binding]; DNA binding site 757424005367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424005368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424005369 homodimer interface [polypeptide binding]; other site 757424005370 catalytic residue [active] 757424005371 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424005372 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 757424005373 putative C-terminal domain interface [polypeptide binding]; other site 757424005374 putative GSH binding site (G-site) [chemical binding]; other site 757424005375 putative dimer interface [polypeptide binding]; other site 757424005376 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 757424005377 putative N-terminal domain interface [polypeptide binding]; other site 757424005378 putative dimer interface [polypeptide binding]; other site 757424005379 putative substrate binding pocket (H-site) [chemical binding]; other site 757424005380 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 757424005381 Domain of unknown function DUF21; Region: DUF21; pfam01595 757424005382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 757424005383 Transporter associated domain; Region: CorC_HlyC; smart01091 757424005384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424005385 GAF domain; Region: GAF; pfam01590 757424005386 pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576 757424005387 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 757424005388 DNA binding residues [nucleotide binding] 757424005389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424005390 GAF domain; Region: GAF; pfam01590 757424005391 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 757424005392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424005393 active site 757424005394 phosphorylation site [posttranslational modification] 757424005395 intermolecular recognition site; other site 757424005396 dimerization interface [polypeptide binding]; other site 757424005397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424005398 dimer interface [polypeptide binding]; other site 757424005399 putative CheW interface [polypeptide binding]; other site 757424005400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424005401 dimer interface [polypeptide binding]; other site 757424005402 putative CheW interface [polypeptide binding]; other site 757424005403 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424005404 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424005405 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424005406 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 757424005407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424005408 active site 757424005409 phosphorylation site [posttranslational modification] 757424005410 intermolecular recognition site; other site 757424005411 dimerization interface [polypeptide binding]; other site 757424005412 CheB methylesterase; Region: CheB_methylest; pfam01339 757424005413 HEAT repeats; Region: HEAT_2; pfam13646 757424005414 HEAT repeats; Region: HEAT_2; pfam13646 757424005415 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 757424005416 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 757424005417 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 757424005418 Response regulator receiver domain; Region: Response_reg; pfam00072 757424005419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424005420 active site 757424005421 phosphorylation site [posttranslational modification] 757424005422 intermolecular recognition site; other site 757424005423 dimerization interface [polypeptide binding]; other site 757424005424 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424005425 putative binding surface; other site 757424005426 active site 757424005427 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 757424005428 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 757424005429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424005430 ATP binding site [chemical binding]; other site 757424005431 Mg2+ binding site [ion binding]; other site 757424005432 G-X-G motif; other site 757424005433 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424005434 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424005436 active site 757424005437 phosphorylation site [posttranslational modification] 757424005438 intermolecular recognition site; other site 757424005439 dimerization interface [polypeptide binding]; other site 757424005440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424005441 dimer interface [polypeptide binding]; other site 757424005442 putative CheW interface [polypeptide binding]; other site 757424005443 PAS fold; Region: PAS_4; pfam08448 757424005444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424005445 putative active site [active] 757424005446 heme pocket [chemical binding]; other site 757424005447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424005448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424005449 metal binding site [ion binding]; metal-binding site 757424005450 active site 757424005451 I-site; other site 757424005452 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424005453 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424005454 dimer interface [polypeptide binding]; other site 757424005455 putative CheW interface [polypeptide binding]; other site 757424005456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424005457 GAF domain; Region: GAF; pfam01590 757424005458 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424005459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424005460 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 757424005461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 757424005462 DNA binding residues [nucleotide binding] 757424005463 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424005464 GAF domain; Region: GAF; pfam01590 757424005465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424005466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424005467 putative substrate translocation pore; other site 757424005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424005469 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 757424005470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005471 dimer interface [polypeptide binding]; other site 757424005472 conserved gate region; other site 757424005473 putative PBP binding loops; other site 757424005474 ABC-ATPase subunit interface; other site 757424005475 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 757424005476 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 757424005477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005478 dimer interface [polypeptide binding]; other site 757424005479 conserved gate region; other site 757424005480 ABC-ATPase subunit interface; other site 757424005481 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 757424005482 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 757424005483 Walker A/P-loop; other site 757424005484 ATP binding site [chemical binding]; other site 757424005485 Q-loop/lid; other site 757424005486 ABC transporter signature motif; other site 757424005487 Walker B; other site 757424005488 D-loop; other site 757424005489 H-loop/switch region; other site 757424005490 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 757424005491 FOG: CBS domain [General function prediction only]; Region: COG0517 757424005492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424005493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424005495 dimerization interface [polypeptide binding]; other site 757424005496 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 757424005497 agmatinase; Region: agmatinase; TIGR01230 757424005498 oligomer interface [polypeptide binding]; other site 757424005499 putative active site [active] 757424005500 Mn binding site [ion binding]; other site 757424005501 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 757424005502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424005503 Coenzyme A binding pocket [chemical binding]; other site 757424005504 helicase 45; Provisional; Region: PTZ00424 757424005505 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 757424005506 ATP binding site [chemical binding]; other site 757424005507 Mg++ binding site [ion binding]; other site 757424005508 motif III; other site 757424005509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424005510 nucleotide binding region [chemical binding]; other site 757424005511 ATP-binding site [chemical binding]; other site 757424005512 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 757424005513 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 757424005514 putative dimer interface [polypeptide binding]; other site 757424005515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424005516 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 757424005517 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 757424005518 active site 757424005519 dimerization interface [polypeptide binding]; other site 757424005520 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 757424005521 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 757424005522 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 757424005523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424005524 RNA binding surface [nucleotide binding]; other site 757424005525 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 757424005526 active site 757424005527 uracil binding [chemical binding]; other site 757424005528 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 757424005529 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 757424005530 dimerization interface [polypeptide binding]; other site 757424005531 domain crossover interface; other site 757424005532 redox-dependent activation switch; other site 757424005533 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 757424005534 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 757424005535 trimer interface [polypeptide binding]; other site 757424005536 putative metal binding site [ion binding]; other site 757424005537 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 757424005538 dinuclear metal binding motif [ion binding]; other site 757424005539 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 757424005540 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 757424005541 nucleophilic elbow; other site 757424005542 catalytic triad; other site 757424005543 RDD family; Region: RDD; pfam06271 757424005544 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 757424005545 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 757424005546 RNA polymerase factor sigma-70; Validated; Region: PRK09047 757424005547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424005548 DNA binding residues [nucleotide binding] 757424005549 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 757424005550 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 757424005551 PYR/PP interface [polypeptide binding]; other site 757424005552 dimer interface [polypeptide binding]; other site 757424005553 TPP binding site [chemical binding]; other site 757424005554 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 757424005555 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 757424005556 TPP-binding site [chemical binding]; other site 757424005557 dimer interface [polypeptide binding]; other site 757424005558 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 757424005559 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 757424005560 putative valine binding site [chemical binding]; other site 757424005561 dimer interface [polypeptide binding]; other site 757424005562 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 757424005563 ketol-acid reductoisomerase; Provisional; Region: PRK05479 757424005564 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 757424005565 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 757424005566 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 757424005567 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 757424005568 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 757424005569 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 757424005570 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424005571 PAS domain; Region: PAS_9; pfam13426 757424005572 PAS domain; Region: PAS_9; pfam13426 757424005573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424005574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424005575 metal binding site [ion binding]; metal-binding site 757424005576 active site 757424005577 I-site; other site 757424005578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424005579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424005580 DNA-binding site [nucleotide binding]; DNA binding site 757424005581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424005582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424005583 homodimer interface [polypeptide binding]; other site 757424005584 catalytic residue [active] 757424005585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 757424005586 TPR repeat; Region: TPR_11; pfam13414 757424005587 binding surface 757424005588 TPR motif; other site 757424005589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424005590 TPR motif; other site 757424005591 binding surface 757424005592 TPR repeat; Region: TPR_11; pfam13414 757424005593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424005594 binding surface 757424005595 TPR motif; other site 757424005596 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 757424005597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424005598 S-adenosylmethionine binding site [chemical binding]; other site 757424005599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424005600 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 757424005601 substrate binding site [chemical binding]; other site 757424005602 ATP binding site [chemical binding]; other site 757424005603 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 757424005604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 757424005605 dimer interface [polypeptide binding]; other site 757424005606 active site 757424005607 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424005608 substrate binding site [chemical binding]; other site 757424005609 catalytic residue [active] 757424005610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 757424005611 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424005612 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424005613 putative active site [active] 757424005614 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 757424005615 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 757424005616 active site 757424005617 putative substrate binding pocket [chemical binding]; other site 757424005618 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 757424005619 homotrimer interaction site [polypeptide binding]; other site 757424005620 putative active site [active] 757424005621 GntP family permease; Region: GntP_permease; pfam02447 757424005622 fructuronate transporter; Provisional; Region: PRK10034; cl15264 757424005623 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 757424005624 16S/18S rRNA binding site [nucleotide binding]; other site 757424005625 S13e-L30e interaction site [polypeptide binding]; other site 757424005626 25S rRNA binding site [nucleotide binding]; other site 757424005627 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 757424005628 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 757424005629 RNase E interface [polypeptide binding]; other site 757424005630 trimer interface [polypeptide binding]; other site 757424005631 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 757424005632 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 757424005633 RNase E interface [polypeptide binding]; other site 757424005634 trimer interface [polypeptide binding]; other site 757424005635 active site 757424005636 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 757424005637 putative nucleic acid binding region [nucleotide binding]; other site 757424005638 G-X-X-G motif; other site 757424005639 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 757424005640 RNA binding site [nucleotide binding]; other site 757424005641 domain interface; other site 757424005642 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 757424005643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424005644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424005645 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 757424005646 Predicted membrane protein [Function unknown]; Region: COG3817 757424005647 Protein of unknown function (DUF979); Region: DUF979; pfam06166 757424005648 Protein of unknown function (DUF969); Region: DUF969; pfam06149 757424005649 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 757424005650 putative active site [active] 757424005651 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 757424005652 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 757424005653 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 757424005654 MarR family; Region: MarR_2; cl17246 757424005655 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 757424005656 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 757424005657 NAD(P) binding site [chemical binding]; other site 757424005658 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 757424005659 substrate binding site [chemical binding]; other site 757424005660 dimer interface [polypeptide binding]; other site 757424005661 catalytic triad [active] 757424005662 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 757424005663 NADH dehydrogenase subunit B; Validated; Region: PRK06411 757424005664 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 757424005665 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 757424005666 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 757424005667 NADH dehydrogenase subunit D; Validated; Region: PRK06075 757424005668 NADH dehydrogenase subunit E; Validated; Region: PRK07539 757424005669 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 757424005670 putative dimer interface [polypeptide binding]; other site 757424005671 [2Fe-2S] cluster binding site [ion binding]; other site 757424005672 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 757424005673 SLBB domain; Region: SLBB; pfam10531 757424005674 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 757424005675 NADH dehydrogenase subunit G; Validated; Region: PRK09129 757424005676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424005677 catalytic loop [active] 757424005678 iron binding site [ion binding]; other site 757424005679 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 757424005680 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 757424005681 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 757424005682 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 757424005683 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 757424005684 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 757424005685 4Fe-4S binding domain; Region: Fer4; pfam00037 757424005686 4Fe-4S binding domain; Region: Fer4; pfam00037 757424005687 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 757424005688 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 757424005689 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 757424005690 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 757424005691 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 757424005692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 757424005693 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 757424005694 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 757424005695 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 757424005696 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 757424005697 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 757424005698 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 757424005699 dimer interface [polypeptide binding]; other site 757424005700 ADP-ribose binding site [chemical binding]; other site 757424005701 active site 757424005702 nudix motif; other site 757424005703 metal binding site [ion binding]; metal-binding site 757424005704 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 757424005705 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424005706 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 757424005707 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 757424005708 active site 757424005709 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424005710 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 757424005711 putative ligand binding site [chemical binding]; other site 757424005712 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424005713 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424005714 TM-ABC transporter signature motif; other site 757424005715 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424005716 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424005717 TM-ABC transporter signature motif; other site 757424005718 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424005719 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424005720 Walker A/P-loop; other site 757424005721 ATP binding site [chemical binding]; other site 757424005722 Q-loop/lid; other site 757424005723 ABC transporter signature motif; other site 757424005724 Walker B; other site 757424005725 D-loop; other site 757424005726 H-loop/switch region; other site 757424005727 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424005728 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424005729 Walker A/P-loop; other site 757424005730 ATP binding site [chemical binding]; other site 757424005731 Q-loop/lid; other site 757424005732 ABC transporter signature motif; other site 757424005733 Walker B; other site 757424005734 D-loop; other site 757424005735 H-loop/switch region; other site 757424005736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424005737 Helix-turn-helix domain; Region: HTH_19; pfam12844 757424005738 non-specific DNA binding site [nucleotide binding]; other site 757424005739 salt bridge; other site 757424005740 sequence-specific DNA binding site [nucleotide binding]; other site 757424005741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424005742 S-adenosylmethionine binding site [chemical binding]; other site 757424005743 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 757424005744 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 757424005745 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 757424005746 putative active site [active] 757424005747 short chain dehydrogenase; Provisional; Region: PRK06123 757424005748 classical (c) SDRs; Region: SDR_c; cd05233 757424005749 NAD(P) binding site [chemical binding]; other site 757424005750 active site 757424005751 Protein of unknown function (DUF962); Region: DUF962; cl01879 757424005752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 757424005753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 757424005754 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 757424005755 heat shock protein 90; Provisional; Region: PRK05218 757424005756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424005757 ATP binding site [chemical binding]; other site 757424005758 Mg2+ binding site [ion binding]; other site 757424005759 G-X-G motif; other site 757424005760 Outer membrane efflux protein; Region: OEP; pfam02321 757424005761 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 757424005762 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424005763 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424005764 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424005765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 757424005766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424005767 Walker A/P-loop; other site 757424005768 ATP binding site [chemical binding]; other site 757424005769 Q-loop/lid; other site 757424005770 ABC transporter signature motif; other site 757424005771 Walker B; other site 757424005772 D-loop; other site 757424005773 H-loop/switch region; other site 757424005774 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424005775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424005776 DNA-binding site [nucleotide binding]; DNA binding site 757424005777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424005778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424005779 homodimer interface [polypeptide binding]; other site 757424005780 catalytic residue [active] 757424005781 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 757424005782 hypothetical protein; Provisional; Region: PRK06110 757424005783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424005784 catalytic residue [active] 757424005785 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 757424005786 EamA-like transporter family; Region: EamA; cl17759 757424005787 EamA-like transporter family; Region: EamA; pfam00892 757424005788 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 757424005789 homotrimer interaction site [polypeptide binding]; other site 757424005790 putative active site [active] 757424005791 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 757424005792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424005793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424005794 homodimer interface [polypeptide binding]; other site 757424005795 catalytic residue [active] 757424005796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 757424005797 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 757424005798 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 757424005799 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 757424005800 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 757424005801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005802 LysR substrate binding domain; Region: LysR_substrate; pfam03466 757424005803 dimerization interface [polypeptide binding]; other site 757424005804 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 757424005805 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 757424005806 putative dimer interface [polypeptide binding]; other site 757424005807 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 757424005808 putative binding surface; other site 757424005809 active site 757424005810 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 757424005811 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424005812 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424005813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424005814 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424005815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 757424005816 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 757424005817 Walker A/P-loop; other site 757424005818 ATP binding site [chemical binding]; other site 757424005819 Q-loop/lid; other site 757424005820 ABC transporter signature motif; other site 757424005821 Walker B; other site 757424005822 D-loop; other site 757424005823 H-loop/switch region; other site 757424005824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 757424005825 Walker A/P-loop; other site 757424005826 ATP binding site [chemical binding]; other site 757424005827 Q-loop/lid; other site 757424005828 ABC transporter signature motif; other site 757424005829 Walker B; other site 757424005830 D-loop; other site 757424005831 H-loop/switch region; other site 757424005832 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 757424005833 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 757424005834 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 757424005835 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 757424005836 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 757424005837 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 757424005838 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 757424005839 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 757424005840 CAP-like domain; other site 757424005841 active site 757424005842 primary dimer interface [polypeptide binding]; other site 757424005843 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424005844 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 757424005845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424005846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424005847 catalytic residue [active] 757424005848 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 757424005849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424005850 ATP binding site [chemical binding]; other site 757424005851 Mg2+ binding site [ion binding]; other site 757424005852 G-X-G motif; other site 757424005853 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 757424005854 anchoring element; other site 757424005855 dimer interface [polypeptide binding]; other site 757424005856 ATP binding site [chemical binding]; other site 757424005857 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 757424005858 active site 757424005859 metal binding site [ion binding]; metal-binding site 757424005860 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 757424005861 amidase; Provisional; Region: PRK07056 757424005862 Amidase; Region: Amidase; cl11426 757424005863 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 757424005864 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 757424005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424005866 putative substrate translocation pore; other site 757424005867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424005868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424005869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424005870 dimerization interface [polypeptide binding]; other site 757424005871 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424005872 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 757424005873 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424005874 putative active site [active] 757424005875 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 757424005876 catalytic nucleophile [active] 757424005877 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 757424005878 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424005879 Walker A/P-loop; other site 757424005880 ATP binding site [chemical binding]; other site 757424005881 Q-loop/lid; other site 757424005882 ABC transporter signature motif; other site 757424005883 Walker B; other site 757424005884 D-loop; other site 757424005885 H-loop/switch region; other site 757424005886 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424005887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424005888 Walker A/P-loop; other site 757424005889 ATP binding site [chemical binding]; other site 757424005890 Q-loop/lid; other site 757424005891 ABC transporter signature motif; other site 757424005892 Walker B; other site 757424005893 D-loop; other site 757424005894 H-loop/switch region; other site 757424005895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424005896 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 757424005897 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 757424005898 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 757424005899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005900 dimer interface [polypeptide binding]; other site 757424005901 conserved gate region; other site 757424005902 putative PBP binding loops; other site 757424005903 ABC-ATPase subunit interface; other site 757424005904 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 757424005905 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 757424005906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424005907 dimer interface [polypeptide binding]; other site 757424005908 conserved gate region; other site 757424005909 putative PBP binding loops; other site 757424005910 ABC-ATPase subunit interface; other site 757424005911 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 757424005912 homodimer interface [polypeptide binding]; other site 757424005913 homotetramer interface [polypeptide binding]; other site 757424005914 active site pocket [active] 757424005915 cleavage site 757424005916 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 757424005917 SxDxEG motif; other site 757424005918 active site 757424005919 metal binding site [ion binding]; metal-binding site 757424005920 homopentamer interface [polypeptide binding]; other site 757424005921 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 757424005922 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 757424005923 RES domain; Region: RES; cl02411 757424005924 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 757424005925 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424005926 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 757424005927 Transcriptional regulators [Transcription]; Region: MarR; COG1846 757424005928 MarR family; Region: MarR; pfam01047 757424005929 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 757424005930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 757424005931 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 757424005932 putative hydrolase; Provisional; Region: PRK11460 757424005933 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 757424005934 MPT binding site; other site 757424005935 trimer interface [polypeptide binding]; other site 757424005936 hypothetical protein; Provisional; Region: PRK05255 757424005937 peptidase PmbA; Provisional; Region: PRK11040 757424005938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424005939 Coenzyme A binding pocket [chemical binding]; other site 757424005940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424005941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424005942 putative substrate translocation pore; other site 757424005943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424005944 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 757424005945 DNA photolyase; Region: DNA_photolyase; pfam00875 757424005946 ribonuclease R; Region: RNase_R; TIGR02063 757424005947 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 757424005948 RNB domain; Region: RNB; pfam00773 757424005949 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 757424005950 RNA binding site [nucleotide binding]; other site 757424005951 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 757424005952 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 757424005953 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 757424005954 serine O-acetyltransferase; Region: cysE; TIGR01172 757424005955 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 757424005956 trimer interface [polypeptide binding]; other site 757424005957 active site 757424005958 substrate binding site [chemical binding]; other site 757424005959 CoA binding site [chemical binding]; other site 757424005960 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 757424005961 putative active site [active] 757424005962 putative metal binding site [ion binding]; other site 757424005963 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 757424005964 substrate binding site [chemical binding]; other site 757424005965 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 757424005966 substrate binding site [chemical binding]; other site 757424005967 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 757424005968 TPR repeat; Region: TPR_11; pfam13414 757424005969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424005970 TPR motif; other site 757424005971 binding surface 757424005972 TPR repeat; Region: TPR_11; pfam13414 757424005973 SnoaL-like domain; Region: SnoaL_3; pfam13474 757424005974 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 757424005975 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 757424005976 active site 757424005977 HIGH motif; other site 757424005978 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 757424005979 KMSKS motif; other site 757424005980 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 757424005981 tRNA binding surface [nucleotide binding]; other site 757424005982 anticodon binding site; other site 757424005983 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 757424005984 endonuclease III; Region: ENDO3c; smart00478 757424005985 minor groove reading motif; other site 757424005986 helix-hairpin-helix signature motif; other site 757424005987 substrate binding pocket [chemical binding]; other site 757424005988 active site 757424005989 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 757424005990 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 757424005991 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 757424005992 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 757424005993 Ligand Binding Site [chemical binding]; other site 757424005994 TilS substrate binding domain; Region: TilS; pfam09179 757424005995 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 757424005996 LysE type translocator; Region: LysE; cl00565 757424005997 psiF repeat; Region: PsiF_repeat; pfam07769 757424005998 psiF repeat; Region: PsiF_repeat; pfam07769 757424005999 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 757424006000 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 757424006001 FtsX-like permease family; Region: FtsX; pfam02687 757424006002 FtsX-like permease family; Region: FtsX; pfam02687 757424006003 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 757424006004 apolar tunnel; other site 757424006005 heme binding site [chemical binding]; other site 757424006006 dimerization interface [polypeptide binding]; other site 757424006007 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 757424006008 RmuC family; Region: RmuC; pfam02646 757424006009 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 757424006010 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 757424006011 dimer interface [polypeptide binding]; other site 757424006012 putative functional site; other site 757424006013 putative MPT binding site; other site 757424006014 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 757424006015 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 757424006016 GTP binding site; other site 757424006017 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 757424006018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424006019 FeS/SAM binding site; other site 757424006020 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 757424006021 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 757424006022 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 757424006023 homodimer interface [polypeptide binding]; other site 757424006024 oligonucleotide binding site [chemical binding]; other site 757424006025 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 757424006026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424006027 RNA binding surface [nucleotide binding]; other site 757424006028 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 757424006029 active site 757424006030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 757424006031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424006032 motif II; other site 757424006033 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 757424006034 iron-sulfur cluster [ion binding]; other site 757424006035 [2Fe-2S] cluster binding site [ion binding]; other site 757424006036 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 757424006037 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 757424006038 tandem repeat interface [polypeptide binding]; other site 757424006039 oligomer interface [polypeptide binding]; other site 757424006040 active site residues [active] 757424006041 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 757424006042 putative SAM binding site [chemical binding]; other site 757424006043 homodimer interface [polypeptide binding]; other site 757424006044 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 757424006045 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 757424006046 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 757424006047 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 757424006048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 757424006049 Protein of unknown function, DUF482; Region: DUF482; pfam04339 757424006050 NAD synthetase; Reviewed; Region: nadE; PRK02628 757424006051 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 757424006052 multimer interface [polypeptide binding]; other site 757424006053 active site 757424006054 catalytic triad [active] 757424006055 protein interface 1 [polypeptide binding]; other site 757424006056 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 757424006057 homodimer interface [polypeptide binding]; other site 757424006058 NAD binding pocket [chemical binding]; other site 757424006059 ATP binding pocket [chemical binding]; other site 757424006060 Mg binding site [ion binding]; other site 757424006061 active-site loop [active] 757424006062 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 757424006063 Nitrogen regulatory protein P-II; Region: P-II; smart00938 757424006064 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 757424006065 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424006066 NAD(P) binding site [chemical binding]; other site 757424006067 catalytic residues [active] 757424006068 Protein of unknown function (DUF779); Region: DUF779; pfam05610 757424006069 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 757424006070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424006071 Walker A motif; other site 757424006072 ATP binding site [chemical binding]; other site 757424006073 Walker B motif; other site 757424006074 arginine finger; other site 757424006075 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424006076 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 757424006077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424006078 FeS/SAM binding site; other site 757424006079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 757424006080 Smr domain; Region: Smr; pfam01713 757424006081 thioredoxin reductase; Provisional; Region: PRK10262 757424006082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424006083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424006084 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 757424006085 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 757424006086 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 757424006087 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 757424006088 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 757424006089 Ferredoxin [Energy production and conversion]; Region: COG1146 757424006090 4Fe-4S binding domain; Region: Fer4; pfam00037 757424006091 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 757424006092 recombination factor protein RarA; Reviewed; Region: PRK13342 757424006093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424006094 Walker A motif; other site 757424006095 ATP binding site [chemical binding]; other site 757424006096 Walker B motif; other site 757424006097 arginine finger; other site 757424006098 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 757424006099 alanine-tRNA ligase; Region: PLN02961 757424006100 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 757424006101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424006102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424006103 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424006104 putative effector binding pocket; other site 757424006105 dimerization interface [polypeptide binding]; other site 757424006106 seryl-tRNA synthetase; Provisional; Region: PRK05431 757424006107 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 757424006108 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 757424006109 dimer interface [polypeptide binding]; other site 757424006110 active site 757424006111 motif 1; other site 757424006112 motif 2; other site 757424006113 motif 3; other site 757424006114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424006115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 757424006116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424006117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424006118 metal binding site [ion binding]; metal-binding site 757424006119 active site 757424006120 I-site; other site 757424006121 HAMP domain; Region: HAMP; pfam00672 757424006122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424006123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424006124 metal binding site [ion binding]; metal-binding site 757424006125 active site 757424006126 I-site; other site 757424006127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424006128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424006129 DNA binding site [nucleotide binding] 757424006130 domain linker motif; other site 757424006131 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 757424006132 putative ligand binding site [chemical binding]; other site 757424006133 putative dimerization interface [polypeptide binding]; other site 757424006134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424006135 MarR family; Region: MarR_2; pfam12802 757424006136 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 757424006137 HPP family; Region: HPP; pfam04982 757424006138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 757424006139 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 757424006140 Maf-like protein; Region: Maf; pfam02545 757424006141 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 757424006142 active site 757424006143 dimer interface [polypeptide binding]; other site 757424006144 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 757424006145 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 757424006146 putative phosphate acyltransferase; Provisional; Region: PRK05331 757424006147 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 757424006148 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 757424006149 dimer interface [polypeptide binding]; other site 757424006150 active site 757424006151 CoA binding pocket [chemical binding]; other site 757424006152 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 757424006153 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 757424006154 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 757424006155 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 757424006156 NAD(P) binding site [chemical binding]; other site 757424006157 homotetramer interface [polypeptide binding]; other site 757424006158 homodimer interface [polypeptide binding]; other site 757424006159 active site 757424006160 acyl carrier protein; Provisional; Region: acpP; PRK00982 757424006161 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 757424006162 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 757424006163 dimer interface [polypeptide binding]; other site 757424006164 active site 757424006165 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 757424006166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424006167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424006168 DNA binding residues [nucleotide binding] 757424006169 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 757424006170 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 757424006171 anti-sigma E factor; Provisional; Region: rseB; PRK09455 757424006172 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 757424006173 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424006174 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 757424006175 protein binding site [polypeptide binding]; other site 757424006176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 757424006177 protein binding site [polypeptide binding]; other site 757424006178 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 757424006179 GTP-binding protein LepA; Provisional; Region: PRK05433 757424006180 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 757424006181 G1 box; other site 757424006182 putative GEF interaction site [polypeptide binding]; other site 757424006183 GTP/Mg2+ binding site [chemical binding]; other site 757424006184 Switch I region; other site 757424006185 G2 box; other site 757424006186 G3 box; other site 757424006187 Switch II region; other site 757424006188 G4 box; other site 757424006189 G5 box; other site 757424006190 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 757424006191 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 757424006192 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 757424006193 signal peptidase I; Provisional; Region: PRK10861 757424006194 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 757424006195 Catalytic site [active] 757424006196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 757424006197 ribonuclease III; Reviewed; Region: rnc; PRK00102 757424006198 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 757424006199 dimerization interface [polypeptide binding]; other site 757424006200 active site 757424006201 metal binding site [ion binding]; metal-binding site 757424006202 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 757424006203 dsRNA binding site [nucleotide binding]; other site 757424006204 GTPase Era; Reviewed; Region: era; PRK00089 757424006205 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 757424006206 G1 box; other site 757424006207 GTP/Mg2+ binding site [chemical binding]; other site 757424006208 Switch I region; other site 757424006209 G2 box; other site 757424006210 Switch II region; other site 757424006211 G3 box; other site 757424006212 G4 box; other site 757424006213 G5 box; other site 757424006214 KH domain; Region: KH_2; pfam07650 757424006215 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 757424006216 Recombination protein O N terminal; Region: RecO_N; pfam11967 757424006217 Recombination protein O C terminal; Region: RecO_C; pfam02565 757424006218 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 757424006219 active site 757424006220 hydrophilic channel; other site 757424006221 dimerization interface [polypeptide binding]; other site 757424006222 catalytic residues [active] 757424006223 active site lid [active] 757424006224 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 757424006225 beta-hexosaminidase; Provisional; Region: PRK05337 757424006226 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 757424006227 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 757424006228 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 757424006229 GIY-YIG motif/motif A; other site 757424006230 active site 757424006231 catalytic site [active] 757424006232 putative DNA binding site [nucleotide binding]; other site 757424006233 metal binding site [ion binding]; metal-binding site 757424006234 UvrB/uvrC motif; Region: UVR; pfam02151 757424006235 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 757424006236 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 757424006237 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 757424006238 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 757424006239 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 757424006240 Walker A/P-loop; other site 757424006241 ATP binding site [chemical binding]; other site 757424006242 Q-loop/lid; other site 757424006243 ABC transporter signature motif; other site 757424006244 Walker B; other site 757424006245 D-loop; other site 757424006246 H-loop/switch region; other site 757424006247 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 757424006248 Walker A/P-loop; other site 757424006249 ATP binding site [chemical binding]; other site 757424006250 Q-loop/lid; other site 757424006251 ABC transporter signature motif; other site 757424006252 Walker B; other site 757424006253 D-loop; other site 757424006254 H-loop/switch region; other site 757424006255 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 757424006256 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 757424006257 ABC-2 type transporter; Region: ABC2_membrane; cl17235 757424006258 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 757424006259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424006260 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424006261 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 757424006262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424006263 dimer interface [polypeptide binding]; other site 757424006264 phosphorylation site [posttranslational modification] 757424006265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424006266 ATP binding site [chemical binding]; other site 757424006267 Mg2+ binding site [ion binding]; other site 757424006268 G-X-G motif; other site 757424006269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424006270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006271 active site 757424006272 phosphorylation site [posttranslational modification] 757424006273 intermolecular recognition site; other site 757424006274 dimerization interface [polypeptide binding]; other site 757424006275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424006276 DNA binding site [nucleotide binding] 757424006277 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 757424006278 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 757424006279 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424006280 catalytic residue [active] 757424006281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 757424006282 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424006283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006284 Response regulator receiver domain; Region: Response_reg; pfam00072 757424006285 active site 757424006286 phosphorylation site [posttranslational modification] 757424006287 intermolecular recognition site; other site 757424006288 dimerization interface [polypeptide binding]; other site 757424006289 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 757424006290 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 757424006291 putative dimer interface [polypeptide binding]; other site 757424006292 active site pocket [active] 757424006293 putative cataytic base [active] 757424006294 cobalamin synthase; Reviewed; Region: cobS; PRK00235 757424006295 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 757424006296 catalytic core [active] 757424006297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006299 active site 757424006300 phosphorylation site [posttranslational modification] 757424006301 intermolecular recognition site; other site 757424006302 dimerization interface [polypeptide binding]; other site 757424006303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424006304 DNA binding residues [nucleotide binding] 757424006305 dimerization interface [polypeptide binding]; other site 757424006306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 757424006307 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 757424006308 Histidine kinase; Region: HisKA_3; pfam07730 757424006309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424006310 ATP binding site [chemical binding]; other site 757424006311 Mg2+ binding site [ion binding]; other site 757424006312 G-X-G motif; other site 757424006313 carbon starvation protein A; Provisional; Region: PRK15015 757424006314 Carbon starvation protein CstA; Region: CstA; pfam02554 757424006315 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 757424006316 Protein of unknown function (DUF466); Region: DUF466; pfam04328 757424006317 heat shock protein HtpX; Provisional; Region: PRK05457 757424006318 putative cation:proton antiport protein; Provisional; Region: PRK10669 757424006319 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 757424006320 TrkA-N domain; Region: TrkA_N; pfam02254 757424006321 riboflavin synthase subunit beta; Provisional; Region: PRK12419 757424006322 active site 757424006323 homopentamer interface [polypeptide binding]; other site 757424006324 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 757424006325 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 757424006326 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 757424006327 homotrimer interaction site [polypeptide binding]; other site 757424006328 putative active site [active] 757424006329 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 757424006330 HD domain; Region: HD_4; pfam13328 757424006331 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 757424006332 synthetase active site [active] 757424006333 NTP binding site [chemical binding]; other site 757424006334 metal binding site [ion binding]; metal-binding site 757424006335 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 757424006336 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 757424006337 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 757424006338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006339 active site 757424006340 phosphorylation site [posttranslational modification] 757424006341 intermolecular recognition site; other site 757424006342 dimerization interface [polypeptide binding]; other site 757424006343 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 757424006344 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 757424006345 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 757424006346 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 757424006347 active site 757424006348 dimer interface [polypeptide binding]; other site 757424006349 motif 1; other site 757424006350 motif 2; other site 757424006351 motif 3; other site 757424006352 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 757424006353 anticodon binding site; other site 757424006354 translation initiation factor IF-3; Region: infC; TIGR00168 757424006355 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 757424006356 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 757424006357 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 757424006358 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 757424006359 23S rRNA binding site [nucleotide binding]; other site 757424006360 L21 binding site [polypeptide binding]; other site 757424006361 L13 binding site [polypeptide binding]; other site 757424006362 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 757424006363 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 757424006364 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 757424006365 dimer interface [polypeptide binding]; other site 757424006366 motif 1; other site 757424006367 active site 757424006368 motif 2; other site 757424006369 motif 3; other site 757424006370 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 757424006371 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 757424006372 putative tRNA-binding site [nucleotide binding]; other site 757424006373 B3/4 domain; Region: B3_4; pfam03483 757424006374 tRNA synthetase B5 domain; Region: B5; smart00874 757424006375 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 757424006376 dimer interface [polypeptide binding]; other site 757424006377 motif 1; other site 757424006378 motif 3; other site 757424006379 motif 2; other site 757424006380 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 757424006381 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 757424006382 IHF dimer interface [polypeptide binding]; other site 757424006383 IHF - DNA interface [nucleotide binding]; other site 757424006384 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 757424006385 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 757424006386 DNA binding residues [nucleotide binding] 757424006387 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 757424006388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424006389 Coenzyme A binding pocket [chemical binding]; other site 757424006390 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 757424006391 active site 757424006392 exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014 757424006393 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 757424006394 Bacterial sugar transferase; Region: Bac_transf; pfam02397 757424006395 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 757424006396 SurA N-terminal domain; Region: SurA_N_3; cl07813 757424006397 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 757424006398 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 757424006399 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 757424006400 SLBB domain; Region: SLBB; pfam10531 757424006401 chain length determinant protein EpsF; Region: EpsF; TIGR03017 757424006402 Chain length determinant protein; Region: Wzz; cl15801 757424006403 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 757424006404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424006405 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 757424006406 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 757424006407 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 757424006408 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 757424006409 O-Antigen ligase; Region: Wzy_C; pfam04932 757424006410 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 757424006411 putative ADP-binding pocket [chemical binding]; other site 757424006412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424006413 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 757424006414 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 757424006415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 757424006416 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 757424006417 DXD motif; other site 757424006418 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 757424006419 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 757424006420 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 757424006421 anti sigma factor interaction site; other site 757424006422 regulatory phosphorylation site [posttranslational modification]; other site 757424006423 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 757424006424 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 757424006425 Substrate binding site; other site 757424006426 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 757424006427 Core-2/I-Branching enzyme; Region: Branch; pfam02485 757424006428 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 757424006429 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424006430 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 757424006431 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 757424006432 colanic acid exporter; Provisional; Region: PRK10459 757424006433 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 757424006434 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 757424006435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 757424006436 active site 757424006437 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 757424006438 trimer interface [polypeptide binding]; other site 757424006439 active site 757424006440 substrate binding site [chemical binding]; other site 757424006441 CoA binding site [chemical binding]; other site 757424006442 UDP-glucose 4-epimerase; Region: PLN02240 757424006443 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 757424006444 NAD binding site [chemical binding]; other site 757424006445 homodimer interface [polypeptide binding]; other site 757424006446 active site 757424006447 substrate binding site [chemical binding]; other site 757424006448 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 757424006449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 757424006450 active site 757424006451 Glycerate kinase family; Region: Gly_kinase; cl00841 757424006452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424006454 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 757424006455 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 757424006456 NAD binding site [chemical binding]; other site 757424006457 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 757424006458 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 757424006459 putative metal binding site [ion binding]; other site 757424006460 putative homodimer interface [polypeptide binding]; other site 757424006461 putative homotetramer interface [polypeptide binding]; other site 757424006462 putative homodimer-homodimer interface [polypeptide binding]; other site 757424006463 putative allosteric switch controlling residues; other site 757424006464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424006465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424006466 dimer interface [polypeptide binding]; other site 757424006467 putative CheW interface [polypeptide binding]; other site 757424006468 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 757424006469 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 757424006470 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 757424006471 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 757424006472 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 757424006473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006474 active site 757424006475 phosphorylation site [posttranslational modification] 757424006476 intermolecular recognition site; other site 757424006477 dimerization interface [polypeptide binding]; other site 757424006478 CheB methylesterase; Region: CheB_methylest; pfam01339 757424006479 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 757424006480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006481 active site 757424006482 phosphorylation site [posttranslational modification] 757424006483 intermolecular recognition site; other site 757424006484 dimerization interface [polypeptide binding]; other site 757424006485 chemotaxis regulator CheZ; Provisional; Region: PRK11166 757424006486 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 757424006487 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 757424006488 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 757424006489 FHIPEP family; Region: FHIPEP; pfam00771 757424006490 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 757424006491 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424006492 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 757424006493 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424006494 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424006495 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 757424006496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424006497 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 757424006498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424006499 DNA binding residues [nucleotide binding] 757424006500 FlgN protein; Region: FlgN; pfam05130 757424006501 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 757424006502 SAF-like; Region: SAF_2; pfam13144 757424006503 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 757424006504 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 757424006505 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 757424006506 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 757424006507 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 757424006508 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 757424006509 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 757424006510 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 757424006511 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 757424006512 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 757424006513 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 757424006514 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 757424006515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 757424006516 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 757424006517 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 757424006518 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 757424006519 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 757424006520 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 757424006521 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 757424006522 Flagellar L-ring protein; Region: FlgH; pfam02107 757424006523 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 757424006524 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 757424006525 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 757424006526 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 757424006527 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 757424006528 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 757424006529 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 757424006530 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 757424006531 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424006532 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 757424006533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424006534 Walker A/P-loop; other site 757424006535 ATP binding site [chemical binding]; other site 757424006536 Q-loop/lid; other site 757424006537 ABC transporter signature motif; other site 757424006538 Walker B; other site 757424006539 D-loop; other site 757424006540 H-loop/switch region; other site 757424006541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 757424006542 FtsX-like permease family; Region: FtsX; pfam02687 757424006543 macrolide transporter subunit MacA; Provisional; Region: PRK11578 757424006544 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424006545 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424006546 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 757424006547 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 757424006548 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 757424006549 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 757424006550 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 757424006551 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 757424006552 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 757424006553 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 757424006554 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 757424006555 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 757424006556 Flagellar FliJ protein; Region: FliJ; pfam02050 757424006557 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 757424006558 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 757424006559 Walker A motif/ATP binding site; other site 757424006560 Walker B motif; other site 757424006561 flagellar assembly protein H; Validated; Region: fliH; PRK05687 757424006562 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 757424006563 Flagellar assembly protein FliH; Region: FliH; pfam02108 757424006564 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 757424006565 FliG C-terminal domain; Region: FliG_C; pfam01706 757424006566 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 757424006567 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 757424006568 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 757424006569 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 757424006570 Flagellar regulator YcgR; Region: YcgR; pfam07317 757424006571 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 757424006572 PilZ domain; Region: PilZ; pfam07238 757424006573 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 757424006574 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 757424006575 Flagellar protein FliT; Region: FliT; pfam05400 757424006576 flagellar protein FliS; Validated; Region: fliS; PRK05685 757424006577 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 757424006578 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 757424006579 FlaG protein; Region: FlaG; pfam03646 757424006580 flagellin; Reviewed; Region: PRK08869 757424006581 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 757424006582 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 757424006583 Tetratricopeptide repeat; Region: TPR_16; pfam13432 757424006584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424006585 TPR motif; other site 757424006586 binding surface 757424006587 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 757424006588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424006589 binding surface 757424006590 TPR motif; other site 757424006591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424006592 binding surface 757424006593 TPR motif; other site 757424006594 LexA repressor; Validated; Region: PRK00215 757424006595 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 757424006596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 757424006597 Catalytic site [active] 757424006598 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 757424006599 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 757424006600 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 757424006601 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 757424006602 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 757424006603 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 757424006604 replicative DNA helicase; Provisional; Region: PRK07004 757424006605 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 757424006606 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 757424006607 Walker A motif; other site 757424006608 ATP binding site [chemical binding]; other site 757424006609 Walker B motif; other site 757424006610 DNA binding loops [nucleotide binding] 757424006611 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 757424006612 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 757424006613 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 757424006614 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 757424006615 putative active site [active] 757424006616 PhoH-like protein; Region: PhoH; pfam02562 757424006617 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 757424006618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 757424006619 catalytic triad [active] 757424006620 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 757424006621 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 757424006622 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 757424006623 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 757424006624 NAD binding site [chemical binding]; other site 757424006625 substrate binding site [chemical binding]; other site 757424006626 active site 757424006627 putative formyltransferase; Provisional; Region: PRK06988 757424006628 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 757424006629 active site 757424006630 substrate binding site [chemical binding]; other site 757424006631 cosubstrate binding site; other site 757424006632 catalytic site [active] 757424006633 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 757424006634 active site 757424006635 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 757424006636 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 757424006637 Ligand binding site; other site 757424006638 Putative Catalytic site; other site 757424006639 DXD motif; other site 757424006640 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 757424006641 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 757424006642 inhibitor-cofactor binding pocket; inhibition site 757424006643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424006644 catalytic residue [active] 757424006645 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 757424006646 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 757424006647 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 757424006648 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 757424006649 aminotransferase AlaT; Validated; Region: PRK09265 757424006650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424006651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424006652 homodimer interface [polypeptide binding]; other site 757424006653 catalytic residue [active] 757424006654 homoserine dehydrogenase; Provisional; Region: PRK06349 757424006655 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 757424006656 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 757424006657 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 757424006658 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 757424006659 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 757424006660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424006661 catalytic residue [active] 757424006662 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 757424006663 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 757424006664 dimer interface [polypeptide binding]; other site 757424006665 putative functional site; other site 757424006666 putative MPT binding site; other site 757424006667 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 757424006668 MoaE interaction surface [polypeptide binding]; other site 757424006669 MoeB interaction surface [polypeptide binding]; other site 757424006670 thiocarboxylated glycine; other site 757424006671 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424006672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424006673 S-adenosylmethionine binding site [chemical binding]; other site 757424006674 GntP family permease; Region: GntP_permease; pfam02447 757424006675 fructuronate transporter; Provisional; Region: PRK10034; cl15264 757424006676 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 757424006677 MoaE homodimer interface [polypeptide binding]; other site 757424006678 MoaD interaction [polypeptide binding]; other site 757424006679 active site residues [active] 757424006680 manganese transport protein MntH; Reviewed; Region: PRK00701 757424006681 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 757424006682 HipA N-terminal domain; Region: Couple_hipA; cl11853 757424006683 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 757424006684 HipA-like N-terminal domain; Region: HipA_N; pfam07805 757424006685 HipA-like C-terminal domain; Region: HipA_C; pfam07804 757424006686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424006687 non-specific DNA binding site [nucleotide binding]; other site 757424006688 salt bridge; other site 757424006689 sequence-specific DNA binding site [nucleotide binding]; other site 757424006690 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 757424006691 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424006692 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424006693 Fusaric acid resistance protein family; Region: FUSC; pfam04632 757424006694 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 757424006695 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424006696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424006697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424006698 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424006699 putative effector binding pocket; other site 757424006700 dimerization interface [polypeptide binding]; other site 757424006701 chromosome condensation membrane protein; Provisional; Region: PRK14196 757424006702 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 757424006703 Clp amino terminal domain; Region: Clp_N; pfam02861 757424006704 Clp amino terminal domain; Region: Clp_N; pfam02861 757424006705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424006706 Walker A motif; other site 757424006707 ATP binding site [chemical binding]; other site 757424006708 Walker B motif; other site 757424006709 arginine finger; other site 757424006710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424006711 Walker A motif; other site 757424006712 ATP binding site [chemical binding]; other site 757424006713 Walker B motif; other site 757424006714 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 757424006715 Cache domain; Region: Cache_1; pfam02743 757424006716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424006717 dimerization interface [polypeptide binding]; other site 757424006718 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424006719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424006720 metal binding site [ion binding]; metal-binding site 757424006721 active site 757424006722 I-site; other site 757424006723 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 757424006724 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 757424006725 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 757424006726 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 757424006727 isocitrate lyase; Provisional; Region: PRK15063 757424006728 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 757424006729 tetramer interface [polypeptide binding]; other site 757424006730 active site 757424006731 Mg2+/Mn2+ binding site [ion binding]; other site 757424006732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424006733 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 757424006734 Walker A/P-loop; other site 757424006735 ATP binding site [chemical binding]; other site 757424006736 Q-loop/lid; other site 757424006737 ABC transporter signature motif; other site 757424006738 Walker B; other site 757424006739 D-loop; other site 757424006740 H-loop/switch region; other site 757424006741 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 757424006742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424006743 dimer interface [polypeptide binding]; other site 757424006744 conserved gate region; other site 757424006745 putative PBP binding loops; other site 757424006746 ABC-ATPase subunit interface; other site 757424006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424006748 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 757424006749 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 757424006750 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 757424006751 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 757424006752 Cl- selectivity filter; other site 757424006753 Cl- binding residues [ion binding]; other site 757424006754 pore gating glutamate residue; other site 757424006755 dimer interface [polypeptide binding]; other site 757424006756 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 757424006757 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 757424006758 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424006759 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 757424006760 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 757424006761 substrate binding site [chemical binding]; other site 757424006762 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 757424006763 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 757424006764 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 757424006765 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 757424006766 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 757424006767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424006768 LysR family transcriptional regulator; Provisional; Region: PRK14997 757424006769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424006770 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424006771 putative effector binding pocket; other site 757424006772 dimerization interface [polypeptide binding]; other site 757424006773 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 757424006774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424006775 Zn2+ binding site [ion binding]; other site 757424006776 Mg2+ binding site [ion binding]; other site 757424006777 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 757424006778 synthetase active site [active] 757424006779 NTP binding site [chemical binding]; other site 757424006780 metal binding site [ion binding]; metal-binding site 757424006781 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 757424006782 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 757424006783 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 757424006784 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 757424006785 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 757424006786 catalytic site [active] 757424006787 G-X2-G-X-G-K; other site 757424006788 hypothetical protein; Provisional; Region: PRK11820 757424006789 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 757424006790 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 757424006791 ribonuclease PH; Reviewed; Region: rph; PRK00173 757424006792 Ribonuclease PH; Region: RNase_PH_bact; cd11362 757424006793 hexamer interface [polypeptide binding]; other site 757424006794 active site 757424006795 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 757424006796 active site 757424006797 dimerization interface [polypeptide binding]; other site 757424006798 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 757424006799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424006800 FeS/SAM binding site; other site 757424006801 HemN C-terminal domain; Region: HemN_C; pfam06969 757424006802 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 757424006803 PAS domain S-box; Region: sensory_box; TIGR00229 757424006804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424006805 putative active site [active] 757424006806 heme pocket [chemical binding]; other site 757424006807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424006808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424006809 metal binding site [ion binding]; metal-binding site 757424006810 active site 757424006811 I-site; other site 757424006812 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424006813 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 757424006814 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 757424006815 E-class dimer interface [polypeptide binding]; other site 757424006816 P-class dimer interface [polypeptide binding]; other site 757424006817 active site 757424006818 Cu2+ binding site [ion binding]; other site 757424006819 Zn2+ binding site [ion binding]; other site 757424006820 aspartate kinase; Reviewed; Region: PRK06635 757424006821 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 757424006822 putative nucleotide binding site [chemical binding]; other site 757424006823 putative catalytic residues [active] 757424006824 putative Mg ion binding site [ion binding]; other site 757424006825 putative aspartate binding site [chemical binding]; other site 757424006826 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 757424006827 putative allosteric regulatory site; other site 757424006828 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 757424006829 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 757424006830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424006831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424006832 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424006833 putative effector binding pocket; other site 757424006834 dimerization interface [polypeptide binding]; other site 757424006835 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 757424006836 catalytic residues [active] 757424006837 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 757424006838 Glycoprotease family; Region: Peptidase_M22; pfam00814 757424006839 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 757424006840 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 757424006841 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 757424006842 Fe-S cluster binding site [ion binding]; other site 757424006843 active site 757424006844 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 757424006845 lysophospholipid transporter LplT; Provisional; Region: PRK11195 757424006846 alanine racemase; Reviewed; Region: dadX; PRK03646 757424006847 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 757424006848 active site 757424006849 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424006850 substrate binding site [chemical binding]; other site 757424006851 catalytic residues [active] 757424006852 dimer interface [polypeptide binding]; other site 757424006853 DNA repair protein RadA; Provisional; Region: PRK11823 757424006854 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 757424006855 Walker A motif/ATP binding site; other site 757424006856 ATP binding site [chemical binding]; other site 757424006857 Walker B motif; other site 757424006858 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 757424006859 Flagellar protein FlhE; Region: FlhE; pfam06366 757424006860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424006861 HAMP domain; Region: HAMP; pfam00672 757424006862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424006863 dimer interface [polypeptide binding]; other site 757424006864 phosphorylation site [posttranslational modification] 757424006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424006866 ATP binding site [chemical binding]; other site 757424006867 Mg2+ binding site [ion binding]; other site 757424006868 G-X-G motif; other site 757424006869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424006870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424006871 active site 757424006872 phosphorylation site [posttranslational modification] 757424006873 intermolecular recognition site; other site 757424006874 dimerization interface [polypeptide binding]; other site 757424006875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424006876 DNA binding site [nucleotide binding] 757424006877 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424006878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424006879 dimer interface [polypeptide binding]; other site 757424006880 conserved gate region; other site 757424006881 putative PBP binding loops; other site 757424006882 ABC-ATPase subunit interface; other site 757424006883 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424006884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424006885 substrate binding pocket [chemical binding]; other site 757424006886 membrane-bound complex binding site; other site 757424006887 hinge residues; other site 757424006888 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 757424006889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424006890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424006891 ABC transporter; Region: ABC_tran_2; pfam12848 757424006892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424006893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424006894 S-adenosylmethionine binding site [chemical binding]; other site 757424006895 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 757424006896 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 757424006897 metal binding site [ion binding]; metal-binding site 757424006898 dimer interface [polypeptide binding]; other site 757424006899 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 757424006900 ArsC family; Region: ArsC; pfam03960 757424006901 putative catalytic residues [active] 757424006902 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 757424006903 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 757424006904 trimer interface [polypeptide binding]; other site 757424006905 active site 757424006906 substrate binding site [chemical binding]; other site 757424006907 CoA binding site [chemical binding]; other site 757424006908 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 757424006909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424006910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424006911 homodimer interface [polypeptide binding]; other site 757424006912 catalytic residue [active] 757424006913 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 757424006914 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424006915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424006916 dimer interface [polypeptide binding]; other site 757424006917 putative CheW interface [polypeptide binding]; other site 757424006918 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 757424006919 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 757424006920 Walker A/P-loop; other site 757424006921 ATP binding site [chemical binding]; other site 757424006922 Q-loop/lid; other site 757424006923 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 757424006924 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 757424006925 Q-loop/lid; other site 757424006926 ABC transporter signature motif; other site 757424006927 Walker B; other site 757424006928 D-loop; other site 757424006929 H-loop/switch region; other site 757424006930 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 757424006931 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 757424006932 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 757424006933 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 757424006934 nucleotide binding pocket [chemical binding]; other site 757424006935 K-X-D-G motif; other site 757424006936 catalytic site [active] 757424006937 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 757424006938 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 757424006939 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 757424006940 DNA binding site [nucleotide binding] 757424006941 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 757424006942 Dimer interface [polypeptide binding]; other site 757424006943 BRCT sequence motif; other site 757424006944 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 757424006945 active site 757424006946 tetramer interface; other site 757424006947 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 757424006948 active site 757424006949 catalytic residues [active] 757424006950 metal binding site [ion binding]; metal-binding site 757424006951 cyanophycin synthetase; Provisional; Region: PRK14016 757424006952 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 757424006953 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424006954 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424006955 cyanophycin synthetase; Provisional; Region: PRK14016 757424006956 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 757424006957 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 757424006958 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 757424006959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424006960 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 757424006961 Walker A/P-loop; other site 757424006962 ATP binding site [chemical binding]; other site 757424006963 Q-loop/lid; other site 757424006964 ABC transporter signature motif; other site 757424006965 Walker B; other site 757424006966 D-loop; other site 757424006967 H-loop/switch region; other site 757424006968 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 757424006969 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 757424006970 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 757424006971 active site 757424006972 PII uridylyl-transferase; Provisional; Region: PRK03059 757424006973 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 757424006974 metal binding triad; other site 757424006975 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 757424006976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424006977 Zn2+ binding site [ion binding]; other site 757424006978 Mg2+ binding site [ion binding]; other site 757424006979 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 757424006980 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 757424006981 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 757424006982 active site 757424006983 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 757424006984 rRNA interaction site [nucleotide binding]; other site 757424006985 S8 interaction site; other site 757424006986 putative laminin-1 binding site; other site 757424006987 elongation factor Ts; Provisional; Region: tsf; PRK09377 757424006988 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 757424006989 Elongation factor TS; Region: EF_TS; pfam00889 757424006990 Elongation factor TS; Region: EF_TS; pfam00889 757424006991 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 757424006992 putative nucleotide binding site [chemical binding]; other site 757424006993 uridine monophosphate binding site [chemical binding]; other site 757424006994 homohexameric interface [polypeptide binding]; other site 757424006995 ribosome recycling factor; Reviewed; Region: frr; PRK00083 757424006996 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 757424006997 hinge region; other site 757424006998 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 757424006999 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 757424007000 catalytic residue [active] 757424007001 putative FPP diphosphate binding site; other site 757424007002 putative FPP binding hydrophobic cleft; other site 757424007003 dimer interface [polypeptide binding]; other site 757424007004 putative IPP diphosphate binding site; other site 757424007005 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 757424007006 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 757424007007 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 757424007008 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 757424007009 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 757424007010 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 757424007011 zinc metallopeptidase RseP; Provisional; Region: PRK10779 757424007012 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 757424007013 active site 757424007014 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 757424007015 protein binding site [polypeptide binding]; other site 757424007016 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 757424007017 protein binding site [polypeptide binding]; other site 757424007018 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 757424007019 putative substrate binding region [chemical binding]; other site 757424007020 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 757424007021 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424007022 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424007023 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424007024 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424007025 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 757424007026 Surface antigen; Region: Bac_surface_Ag; pfam01103 757424007027 periplasmic chaperone; Provisional; Region: PRK10780 757424007028 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 757424007029 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 757424007030 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 757424007031 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 757424007032 trimer interface [polypeptide binding]; other site 757424007033 active site 757424007034 UDP-GlcNAc binding site [chemical binding]; other site 757424007035 lipid binding site [chemical binding]; lipid-binding site 757424007036 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 757424007037 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 757424007038 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 757424007039 active site 757424007040 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 757424007041 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 757424007042 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 757424007043 RNA/DNA hybrid binding site [nucleotide binding]; other site 757424007044 active site 757424007045 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 757424007046 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 757424007047 PEP synthetase regulatory protein; Provisional; Region: PRK05339 757424007048 phosphoenolpyruvate synthase; Validated; Region: PRK06464 757424007049 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 757424007050 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 757424007051 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 757424007052 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 757424007053 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 757424007054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 757424007055 Beta-lactamase; Region: Beta-lactamase; pfam00144 757424007056 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 757424007057 dimerization interface [polypeptide binding]; other site 757424007058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424007059 dimer interface [polypeptide binding]; other site 757424007060 phosphorylation site [posttranslational modification] 757424007061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007062 ATP binding site [chemical binding]; other site 757424007063 Mg2+ binding site [ion binding]; other site 757424007064 G-X-G motif; other site 757424007065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424007066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007067 active site 757424007068 phosphorylation site [posttranslational modification] 757424007069 intermolecular recognition site; other site 757424007070 dimerization interface [polypeptide binding]; other site 757424007071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424007072 DNA binding site [nucleotide binding] 757424007073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424007074 TPR motif; other site 757424007075 binding surface 757424007076 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 757424007077 SmpB-tmRNA interface; other site 757424007078 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 757424007079 putative coenzyme Q binding site [chemical binding]; other site 757424007080 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 757424007081 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 757424007082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 757424007083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 757424007084 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 757424007085 active site 757424007086 GMP synthase; Reviewed; Region: guaA; PRK00074 757424007087 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 757424007088 AMP/PPi binding site [chemical binding]; other site 757424007089 candidate oxyanion hole; other site 757424007090 catalytic triad [active] 757424007091 potential glutamine specificity residues [chemical binding]; other site 757424007092 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 757424007093 ATP Binding subdomain [chemical binding]; other site 757424007094 Ligand Binding sites [chemical binding]; other site 757424007095 Dimerization subdomain; other site 757424007096 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 757424007097 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 757424007098 Protein of unknown function DUF72; Region: DUF72; pfam01904 757424007099 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 757424007100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424007101 FeS/SAM binding site; other site 757424007102 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 757424007103 active site 757424007104 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 757424007105 nucleoside/Zn binding site; other site 757424007106 dimer interface [polypeptide binding]; other site 757424007107 catalytic motif [active] 757424007108 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 757424007109 dimer interface [polypeptide binding]; other site 757424007110 catalytic triad [active] 757424007111 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 757424007112 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424007113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424007114 ABC transporter; Region: ABC_tran_2; pfam12848 757424007115 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424007116 quinolinate synthetase; Provisional; Region: PRK09375 757424007117 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 757424007118 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 757424007119 dimerization interface [polypeptide binding]; other site 757424007120 active site 757424007121 MASE1; Region: MASE1; cl17823 757424007122 hypothetical protein; Provisional; Region: PRK10279 757424007123 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 757424007124 active site 757424007125 nucleophile elbow; other site 757424007126 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 757424007127 Surface antigen; Region: Bac_surface_Ag; pfam01103 757424007128 L-aspartate oxidase; Provisional; Region: PRK09077 757424007129 L-aspartate oxidase; Provisional; Region: PRK06175 757424007130 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 757424007131 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 757424007132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424007133 ATP-grasp domain; Region: ATP-grasp; pfam02222 757424007134 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 757424007135 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 757424007136 oligomeric interface; other site 757424007137 putative active site [active] 757424007138 homodimer interface [polypeptide binding]; other site 757424007139 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 757424007140 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 757424007141 Citrate transporter; Region: CitMHS; pfam03600 757424007142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424007143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424007144 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 757424007145 putative dimerization interface [polypeptide binding]; other site 757424007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424007147 putative substrate translocation pore; other site 757424007148 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 757424007149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424007150 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424007151 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 757424007152 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 757424007153 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 757424007154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424007155 dimer interface [polypeptide binding]; other site 757424007156 conserved gate region; other site 757424007157 putative PBP binding loops; other site 757424007158 ABC-ATPase subunit interface; other site 757424007159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424007160 dimer interface [polypeptide binding]; other site 757424007161 conserved gate region; other site 757424007162 putative PBP binding loops; other site 757424007163 ABC-ATPase subunit interface; other site 757424007164 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 757424007165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424007166 Walker A/P-loop; other site 757424007167 ATP binding site [chemical binding]; other site 757424007168 Q-loop/lid; other site 757424007169 ABC transporter signature motif; other site 757424007170 Walker B; other site 757424007171 D-loop; other site 757424007172 H-loop/switch region; other site 757424007173 SurA N-terminal domain; Region: SurA_N_3; cl07813 757424007174 periplasmic folding chaperone; Provisional; Region: PRK10788 757424007175 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 757424007176 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 757424007177 Glutamine amidotransferase class-I; Region: GATase; pfam00117 757424007178 catalytic triad [active] 757424007179 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 757424007180 active site 757424007181 catalytic triad [active] 757424007182 oxyanion hole [active] 757424007183 switch loop; other site 757424007184 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 757424007185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424007186 Walker A/P-loop; other site 757424007187 ATP binding site [chemical binding]; other site 757424007188 Q-loop/lid; other site 757424007189 ABC transporter signature motif; other site 757424007190 Walker B; other site 757424007191 D-loop; other site 757424007192 H-loop/switch region; other site 757424007193 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424007194 putative carbohydrate kinase; Provisional; Region: PRK10565 757424007195 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 757424007196 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 757424007197 putative substrate binding site [chemical binding]; other site 757424007198 putative ATP binding site [chemical binding]; other site 757424007199 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 757424007200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424007201 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 757424007202 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 757424007203 dimerization interface [polypeptide binding]; other site 757424007204 ATP binding site [chemical binding]; other site 757424007205 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 757424007206 dimerization interface [polypeptide binding]; other site 757424007207 ATP binding site [chemical binding]; other site 757424007208 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 757424007209 putative active site [active] 757424007210 catalytic triad [active] 757424007211 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424007212 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424007213 trimer interface [polypeptide binding]; other site 757424007214 eyelet of channel; other site 757424007215 SurA N-terminal domain; Region: SurA_N_3; cl07813 757424007216 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 757424007217 BolA-like protein; Region: BolA; pfam01722 757424007218 intracellular septation protein A; Reviewed; Region: PRK00259 757424007219 methionine sulfoxide reductase B; Provisional; Region: PRK00222 757424007220 SelR domain; Region: SelR; pfam01641 757424007221 Uncharacterized conserved protein [Function unknown]; Region: COG0397 757424007222 hypothetical protein; Validated; Region: PRK00029 757424007223 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424007224 TM-ABC transporter signature motif; other site 757424007225 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424007226 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424007227 TM-ABC transporter signature motif; other site 757424007228 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424007229 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424007230 Walker A/P-loop; other site 757424007231 ATP binding site [chemical binding]; other site 757424007232 Q-loop/lid; other site 757424007233 ABC transporter signature motif; other site 757424007234 Walker B; other site 757424007235 D-loop; other site 757424007236 H-loop/switch region; other site 757424007237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424007238 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424007239 Walker A/P-loop; other site 757424007240 ATP binding site [chemical binding]; other site 757424007241 Q-loop/lid; other site 757424007242 ABC transporter signature motif; other site 757424007243 Walker B; other site 757424007244 D-loop; other site 757424007245 H-loop/switch region; other site 757424007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424007247 D-galactonate transporter; Region: 2A0114; TIGR00893 757424007248 putative substrate translocation pore; other site 757424007249 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 757424007250 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 757424007251 putative NAD(P) binding site [chemical binding]; other site 757424007252 active site 757424007253 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424007254 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 757424007255 NAD(P) binding site [chemical binding]; other site 757424007256 catalytic residues [active] 757424007257 catalytic residues [active] 757424007258 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424007259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424007260 DNA-binding site [nucleotide binding]; DNA binding site 757424007261 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424007262 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 757424007263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424007264 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 757424007265 putative dimerization interface [polypeptide binding]; other site 757424007266 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424007267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424007268 metal binding site [ion binding]; metal-binding site 757424007269 active site 757424007270 I-site; other site 757424007271 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 757424007272 putative active site [active] 757424007273 putative PHP Thumb interface [polypeptide binding]; other site 757424007274 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 757424007275 DNA Polymerase Y-family; Region: PolY_like; cd03468 757424007276 active site 757424007277 DNA binding site [nucleotide binding] 757424007278 Uncharacterized conserved protein [Function unknown]; Region: COG4544 757424007279 Fic family protein [Function unknown]; Region: COG3177 757424007280 Fic/DOC family; Region: Fic; pfam02661 757424007281 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 757424007282 FOG: CBS domain [General function prediction only]; Region: COG0517 757424007283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 757424007284 intracellular protease, PfpI family; Region: PfpI; TIGR01382 757424007285 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 757424007286 proposed catalytic triad [active] 757424007287 conserved cys residue [active] 757424007288 pyruvate dehydrogenase; Provisional; Region: PRK09124 757424007289 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 757424007290 PYR/PP interface [polypeptide binding]; other site 757424007291 tetramer interface [polypeptide binding]; other site 757424007292 dimer interface [polypeptide binding]; other site 757424007293 TPP binding site [chemical binding]; other site 757424007294 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 757424007295 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 757424007296 TPP-binding site [chemical binding]; other site 757424007297 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 757424007298 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 757424007299 putative DNA binding site [nucleotide binding]; other site 757424007300 putative homodimer interface [polypeptide binding]; other site 757424007301 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 757424007302 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 757424007303 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 757424007304 active site 757424007305 DNA binding site [nucleotide binding] 757424007306 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 757424007307 DNA binding site [nucleotide binding] 757424007308 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 757424007309 nucleotide binding site [chemical binding]; other site 757424007310 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 757424007311 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 757424007312 GIY-YIG motif/motif A; other site 757424007313 active site 757424007314 catalytic site [active] 757424007315 putative DNA binding site [nucleotide binding]; other site 757424007316 metal binding site [ion binding]; metal-binding site 757424007317 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 757424007318 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424007319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424007320 substrate binding pocket [chemical binding]; other site 757424007321 membrane-bound complex binding site; other site 757424007322 hinge residues; other site 757424007323 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 757424007324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 757424007325 putative active site [active] 757424007326 putative metal binding site [ion binding]; other site 757424007327 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 757424007328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424007329 ATP binding site [chemical binding]; other site 757424007330 putative Mg++ binding site [ion binding]; other site 757424007331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424007332 nucleotide binding region [chemical binding]; other site 757424007333 ATP-binding site [chemical binding]; other site 757424007334 DEAD/H associated; Region: DEAD_assoc; pfam08494 757424007335 ATP-dependent DNA ligase; Validated; Region: PRK09247 757424007336 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 757424007337 active site 757424007338 DNA binding site [nucleotide binding] 757424007339 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 757424007340 DNA binding site [nucleotide binding] 757424007341 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 757424007342 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424007343 HDOD domain; Region: HDOD; pfam08668 757424007344 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 757424007345 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 757424007346 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 757424007347 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 757424007348 substrate binding site [chemical binding]; other site 757424007349 ligand binding site [chemical binding]; other site 757424007350 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 757424007351 substrate binding site [chemical binding]; other site 757424007352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424007353 DNA-binding site [nucleotide binding]; DNA binding site 757424007354 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424007355 FCD domain; Region: FCD; pfam07729 757424007356 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424007357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424007358 putative DNA binding site [nucleotide binding]; other site 757424007359 putative Zn2+ binding site [ion binding]; other site 757424007360 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424007361 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424007362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424007363 substrate binding pocket [chemical binding]; other site 757424007364 membrane-bound complex binding site; other site 757424007365 hinge residues; other site 757424007366 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424007367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424007368 dimer interface [polypeptide binding]; other site 757424007369 conserved gate region; other site 757424007370 putative PBP binding loops; other site 757424007371 ABC-ATPase subunit interface; other site 757424007372 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424007373 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424007374 Walker A/P-loop; other site 757424007375 ATP binding site [chemical binding]; other site 757424007376 Q-loop/lid; other site 757424007377 ABC transporter signature motif; other site 757424007378 Walker B; other site 757424007379 D-loop; other site 757424007380 H-loop/switch region; other site 757424007381 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 757424007382 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 757424007383 active site 757424007384 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 757424007385 Ligand Binding Site [chemical binding]; other site 757424007386 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 757424007387 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 757424007388 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424007389 ligand binding site [chemical binding]; other site 757424007390 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424007391 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424007392 Walker A/P-loop; other site 757424007393 ATP binding site [chemical binding]; other site 757424007394 Q-loop/lid; other site 757424007395 ABC transporter signature motif; other site 757424007396 Walker B; other site 757424007397 D-loop; other site 757424007398 H-loop/switch region; other site 757424007399 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424007400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424007401 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424007402 TM-ABC transporter signature motif; other site 757424007403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424007404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424007405 DNA binding site [nucleotide binding] 757424007406 domain linker motif; other site 757424007407 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424007408 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424007409 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 757424007410 substrate binding site [chemical binding]; other site 757424007411 dimer interface [polypeptide binding]; other site 757424007412 ATP binding site [chemical binding]; other site 757424007413 D-ribose pyranase; Provisional; Region: PRK11797 757424007414 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424007415 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424007416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424007417 dimerization interface [polypeptide binding]; other site 757424007418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424007419 dimer interface [polypeptide binding]; other site 757424007420 putative CheW interface [polypeptide binding]; other site 757424007421 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 757424007422 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 757424007423 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 757424007424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424007425 catalytic site [active] 757424007426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424007427 PAS fold; Region: PAS_3; pfam08447 757424007428 putative active site [active] 757424007429 heme pocket [chemical binding]; other site 757424007430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424007431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424007432 dimer interface [polypeptide binding]; other site 757424007433 phosphorylation site [posttranslational modification] 757424007434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007435 ATP binding site [chemical binding]; other site 757424007436 Mg2+ binding site [ion binding]; other site 757424007437 G-X-G motif; other site 757424007438 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424007439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007440 active site 757424007441 phosphorylation site [posttranslational modification] 757424007442 intermolecular recognition site; other site 757424007443 dimerization interface [polypeptide binding]; other site 757424007444 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 757424007445 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 757424007446 short chain dehydrogenase; Provisional; Region: PRK07109 757424007447 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 757424007448 putative NAD(P) binding site [chemical binding]; other site 757424007449 active site 757424007450 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 757424007451 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424007452 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 757424007453 Cytochrome c; Region: Cytochrom_C; cl11414 757424007454 Cytochrome c; Region: Cytochrom_C; pfam00034 757424007455 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 757424007456 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 757424007457 Subunit I/III interface [polypeptide binding]; other site 757424007458 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 757424007459 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 757424007460 D-pathway; other site 757424007461 Putative ubiquinol binding site [chemical binding]; other site 757424007462 Low-spin heme (heme b) binding site [chemical binding]; other site 757424007463 Putative water exit pathway; other site 757424007464 Binuclear center (heme o3/CuB) [ion binding]; other site 757424007465 K-pathway; other site 757424007466 Putative proton exit pathway; other site 757424007467 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 757424007468 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 757424007469 Cytochrome c; Region: Cytochrom_C; pfam00034 757424007470 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 757424007471 Predicted transporter component [General function prediction only]; Region: COG2391 757424007472 Sulphur transport; Region: Sulf_transp; pfam04143 757424007473 Predicted transporter component [General function prediction only]; Region: COG2391 757424007474 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 757424007475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424007476 dimerization interface [polypeptide binding]; other site 757424007477 putative DNA binding site [nucleotide binding]; other site 757424007478 putative Zn2+ binding site [ion binding]; other site 757424007479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424007480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424007481 LysR substrate binding domain; Region: LysR_substrate; pfam03466 757424007482 dimerization interface [polypeptide binding]; other site 757424007483 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 757424007484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 757424007485 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 757424007486 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 757424007487 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 757424007488 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 757424007489 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 757424007490 Walker A/P-loop; other site 757424007491 ATP binding site [chemical binding]; other site 757424007492 Q-loop/lid; other site 757424007493 ABC transporter signature motif; other site 757424007494 Walker B; other site 757424007495 D-loop; other site 757424007496 H-loop/switch region; other site 757424007497 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 757424007498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424007499 dimer interface [polypeptide binding]; other site 757424007500 conserved gate region; other site 757424007501 ABC-ATPase subunit interface; other site 757424007502 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 757424007503 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 757424007504 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 757424007505 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 757424007506 active site 757424007507 homodimer interface [polypeptide binding]; other site 757424007508 catalytic site [active] 757424007509 acceptor binding site [chemical binding]; other site 757424007510 trehalose synthase; Region: treS_nterm; TIGR02456 757424007511 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 757424007512 active site 757424007513 catalytic site [active] 757424007514 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 757424007515 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 757424007516 glycogen branching enzyme; Provisional; Region: PRK05402 757424007517 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 757424007518 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 757424007519 active site 757424007520 catalytic site [active] 757424007521 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 757424007522 Hemerythrin-like domain; Region: Hr-like; cd12108 757424007523 Fe binding site [ion binding]; other site 757424007524 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424007525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424007526 dimer interface [polypeptide binding]; other site 757424007527 conserved gate region; other site 757424007528 putative PBP binding loops; other site 757424007529 ABC-ATPase subunit interface; other site 757424007530 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 757424007531 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424007532 Walker A/P-loop; other site 757424007533 ATP binding site [chemical binding]; other site 757424007534 Q-loop/lid; other site 757424007535 ABC transporter signature motif; other site 757424007536 Walker B; other site 757424007537 D-loop; other site 757424007538 H-loop/switch region; other site 757424007539 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 757424007540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424007541 substrate binding pocket [chemical binding]; other site 757424007542 membrane-bound complex binding site; other site 757424007543 hinge residues; other site 757424007544 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 757424007545 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 757424007546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424007547 catalytic residue [active] 757424007548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424007549 non-specific DNA binding site [nucleotide binding]; other site 757424007550 salt bridge; other site 757424007551 sequence-specific DNA binding site [nucleotide binding]; other site 757424007552 serine O-acetyltransferase; Region: cysE; TIGR01172 757424007553 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 757424007554 trimer interface [polypeptide binding]; other site 757424007555 active site 757424007556 substrate binding site [chemical binding]; other site 757424007557 CoA binding site [chemical binding]; other site 757424007558 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 757424007559 active site residue [active] 757424007560 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424007561 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 757424007562 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424007563 N-terminal plug; other site 757424007564 ligand-binding site [chemical binding]; other site 757424007565 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 757424007566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424007567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424007568 DNA binding residues [nucleotide binding] 757424007569 MbtH-like protein; Region: MbtH; cl01279 757424007570 Thioesterase domain; Region: Thioesterase; pfam00975 757424007571 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 757424007572 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 757424007573 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 757424007574 AMP-binding enzyme; Region: AMP-binding; pfam00501 757424007575 acyl-activating enzyme (AAE) consensus motif; other site 757424007576 active site 757424007577 Condensation domain; Region: Condensation; pfam00668 757424007578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 757424007579 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 757424007580 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007581 acyl-activating enzyme (AAE) consensus motif; other site 757424007582 AMP binding site [chemical binding]; other site 757424007583 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424007584 Condensation domain; Region: Condensation; pfam00668 757424007585 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 757424007586 Condensation domain; Region: Condensation; pfam00668 757424007587 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 757424007588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007589 acyl-activating enzyme (AAE) consensus motif; other site 757424007590 AMP binding site [chemical binding]; other site 757424007591 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 757424007592 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 757424007593 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007594 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 757424007595 acyl-activating enzyme (AAE) consensus motif; other site 757424007596 AMP binding site [chemical binding]; other site 757424007597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424007598 Condensation domain; Region: Condensation; pfam00668 757424007599 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 757424007600 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 757424007601 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007602 acyl-activating enzyme (AAE) consensus motif; other site 757424007603 AMP binding site [chemical binding]; other site 757424007604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424007605 Condensation domain; Region: Condensation; pfam00668 757424007606 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 757424007607 Condensation domain; Region: Condensation; pfam00668 757424007608 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 757424007609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007610 acyl-activating enzyme (AAE) consensus motif; other site 757424007611 AMP binding site [chemical binding]; other site 757424007612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424007613 Condensation domain; Region: Condensation; pfam00668 757424007614 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 757424007615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 757424007616 acyl-activating enzyme (AAE) consensus motif; other site 757424007617 AMP binding site [chemical binding]; other site 757424007618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 757424007619 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 757424007620 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 757424007621 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 757424007622 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424007623 N-terminal plug; other site 757424007624 ligand-binding site [chemical binding]; other site 757424007625 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 757424007626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424007627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 757424007628 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 757424007629 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 757424007630 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 757424007631 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 757424007632 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 757424007633 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 757424007634 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 757424007635 Walker A/P-loop; other site 757424007636 ATP binding site [chemical binding]; other site 757424007637 Q-loop/lid; other site 757424007638 ABC transporter signature motif; other site 757424007639 Walker B; other site 757424007640 D-loop; other site 757424007641 H-loop/switch region; other site 757424007642 Hepatitis C virus capsid protein; Region: HCV_capsid; pfam01543 757424007643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424007644 non-specific DNA binding site [nucleotide binding]; other site 757424007645 salt bridge; other site 757424007646 sequence-specific DNA binding site [nucleotide binding]; other site 757424007647 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 757424007648 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424007649 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424007650 catalytic residue [active] 757424007651 SnoaL-like domain; Region: SnoaL_2; pfam12680 757424007652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 757424007653 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 757424007654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424007655 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 757424007656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424007657 motif II; other site 757424007658 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 757424007659 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 757424007660 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 757424007661 conserved cys residue [active] 757424007662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424007663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424007664 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 757424007665 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 757424007666 ligand binding site [chemical binding]; other site 757424007667 flexible hinge region; other site 757424007668 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 757424007669 putative switch regulator; other site 757424007670 non-specific DNA interactions [nucleotide binding]; other site 757424007671 DNA binding site [nucleotide binding] 757424007672 sequence specific DNA binding site [nucleotide binding]; other site 757424007673 putative cAMP binding site [chemical binding]; other site 757424007674 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 757424007675 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 757424007676 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 757424007677 acyl-activating enzyme (AAE) consensus motif; other site 757424007678 active site 757424007679 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 757424007680 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424007681 putative acyl-acceptor binding pocket; other site 757424007682 hypothetical protein; Provisional; Region: PRK08609 757424007683 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 757424007684 active site 757424007685 primer binding site [nucleotide binding]; other site 757424007686 NTP binding site [chemical binding]; other site 757424007687 metal binding triad [ion binding]; metal-binding site 757424007688 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 757424007689 active site 757424007690 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 757424007691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424007692 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 757424007693 Hemerythrin-like domain; Region: Hr-like; cd12108 757424007694 Fe binding site [ion binding]; other site 757424007695 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424007696 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 757424007697 Walker A/P-loop; other site 757424007698 ATP binding site [chemical binding]; other site 757424007699 Q-loop/lid; other site 757424007700 ABC transporter signature motif; other site 757424007701 Walker B; other site 757424007702 D-loop; other site 757424007703 H-loop/switch region; other site 757424007704 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424007705 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 757424007706 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424007707 DevC protein; Region: devC; TIGR01185 757424007708 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 757424007709 FtsX-like permease family; Region: FtsX; pfam02687 757424007710 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424007711 Dodecin; Region: Dodecin; pfam07311 757424007712 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 757424007713 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 757424007714 putative dimer interface [polypeptide binding]; other site 757424007715 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 757424007716 BON domain; Region: BON; pfam04972 757424007717 BON domain; Region: BON; pfam04972 757424007718 BON domain; Region: BON; pfam04972 757424007719 Dodecin; Region: Dodecin; pfam07311 757424007720 Hemerythrin family; Region: Hemerythrin-like; cl15774 757424007721 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 757424007722 BON domain; Region: BON; pfam04972 757424007723 BON domain; Region: BON; pfam04972 757424007724 BON domain; Region: BON; pfam04972 757424007725 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 757424007726 Ligand Binding Site [chemical binding]; other site 757424007727 Hemerythrin; Region: Hemerythrin; cd12107 757424007728 Fe binding site [ion binding]; other site 757424007729 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 757424007730 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 757424007731 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 757424007732 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 757424007733 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 757424007734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424007735 NAD(P) binding site [chemical binding]; other site 757424007736 active site 757424007737 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 757424007738 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 757424007739 dimer interaction site [polypeptide binding]; other site 757424007740 substrate-binding tunnel; other site 757424007741 active site 757424007742 catalytic site [active] 757424007743 substrate binding site [chemical binding]; other site 757424007744 phosphate acetyltransferase; Provisional; Region: PRK11890 757424007745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424007746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424007747 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 757424007748 putative dimerization interface [polypeptide binding]; other site 757424007749 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 757424007750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424007751 S-adenosylmethionine binding site [chemical binding]; other site 757424007752 Cupin; Region: Cupin_6; pfam12852 757424007753 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424007754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424007755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424007756 short chain dehydrogenase; Provisional; Region: PRK08267 757424007757 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 757424007758 NADP binding site [chemical binding]; other site 757424007759 active site 757424007760 steroid binding site; other site 757424007761 indole acetimide hydrolase; Validated; Region: PRK07488 757424007762 Amidase; Region: Amidase; pfam01425 757424007763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424007764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424007765 DNA binding residues [nucleotide binding] 757424007766 dimerization interface [polypeptide binding]; other site 757424007767 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 757424007768 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 757424007769 active site 757424007770 catalytic residues [active] 757424007771 Putative zinc-finger; Region: zf-HC2; pfam13490 757424007772 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 757424007773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424007774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424007775 DNA binding residues [nucleotide binding] 757424007776 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 757424007777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 757424007778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 757424007779 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 757424007780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 757424007781 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 757424007782 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 757424007783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424007784 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424007785 putative active site [active] 757424007786 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 757424007787 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424007788 putative ligand binding site [chemical binding]; other site 757424007789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424007790 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424007791 TM-ABC transporter signature motif; other site 757424007792 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 757424007793 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424007794 Walker A/P-loop; other site 757424007795 ATP binding site [chemical binding]; other site 757424007796 Q-loop/lid; other site 757424007797 ABC transporter signature motif; other site 757424007798 Walker B; other site 757424007799 D-loop; other site 757424007800 H-loop/switch region; other site 757424007801 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424007802 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 757424007803 substrate binding site [chemical binding]; other site 757424007804 ATP binding site [chemical binding]; other site 757424007805 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 757424007806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 757424007807 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 757424007808 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 757424007809 PYR/PP interface [polypeptide binding]; other site 757424007810 dimer interface [polypeptide binding]; other site 757424007811 TPP binding site [chemical binding]; other site 757424007812 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 757424007813 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 757424007814 TPP-binding site; other site 757424007815 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 757424007816 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 757424007817 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 757424007818 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 757424007819 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 757424007820 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 757424007821 FecR protein; Region: FecR; pfam04773 757424007822 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 757424007823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424007824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424007825 DNA binding residues [nucleotide binding] 757424007826 K+ potassium transporter; Region: K_trans; cl15781 757424007827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424007828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007829 active site 757424007830 phosphorylation site [posttranslational modification] 757424007831 intermolecular recognition site; other site 757424007832 dimerization interface [polypeptide binding]; other site 757424007833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424007834 DNA binding site [nucleotide binding] 757424007835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424007836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424007837 dimer interface [polypeptide binding]; other site 757424007838 phosphorylation site [posttranslational modification] 757424007839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007840 ATP binding site [chemical binding]; other site 757424007841 Mg2+ binding site [ion binding]; other site 757424007842 G-X-G motif; other site 757424007843 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 757424007844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424007845 dimer interface [polypeptide binding]; other site 757424007846 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424007847 putative CheW interface [polypeptide binding]; other site 757424007848 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 757424007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424007850 putative substrate translocation pore; other site 757424007851 DNA polymerase II; Reviewed; Region: PRK05762 757424007852 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 757424007853 active site 757424007854 catalytic site [active] 757424007855 substrate binding site [chemical binding]; other site 757424007856 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 757424007857 active site 757424007858 metal-binding site 757424007859 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 757424007860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424007861 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424007862 DNA-binding site [nucleotide binding]; DNA binding site 757424007863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424007864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424007865 homodimer interface [polypeptide binding]; other site 757424007866 catalytic residue [active] 757424007867 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 757424007868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424007869 short chain dehydrogenase; Provisional; Region: PRK06180 757424007870 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 757424007871 NADP binding site [chemical binding]; other site 757424007872 active site 757424007873 steroid binding site; other site 757424007874 Cupin; Region: Cupin_6; pfam12852 757424007875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424007876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424007877 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424007878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424007879 DNA-binding site [nucleotide binding]; DNA binding site 757424007880 FCD domain; Region: FCD; pfam07729 757424007881 biotin synthase; Region: bioB; TIGR00433 757424007882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424007883 FeS/SAM binding site; other site 757424007884 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 757424007885 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 757424007886 Cytochrome P450; Region: p450; cl12078 757424007887 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 757424007888 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 757424007889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424007890 catalytic residue [active] 757424007891 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 757424007892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424007893 inhibitor-cofactor binding pocket; inhibition site 757424007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424007895 catalytic residue [active] 757424007896 AAA domain; Region: AAA_26; pfam13500 757424007897 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 757424007898 histidine kinase; Provisional; Region: PRK13557 757424007899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424007900 putative active site [active] 757424007901 heme pocket [chemical binding]; other site 757424007902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424007903 dimer interface [polypeptide binding]; other site 757424007904 phosphorylation site [posttranslational modification] 757424007905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007906 ATP binding site [chemical binding]; other site 757424007907 Mg2+ binding site [ion binding]; other site 757424007908 G-X-G motif; other site 757424007909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007910 active site 757424007911 phosphorylation site [posttranslational modification] 757424007912 intermolecular recognition site; other site 757424007913 dimerization interface [polypeptide binding]; other site 757424007914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424007915 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424007916 Walker A/P-loop; other site 757424007917 ATP binding site [chemical binding]; other site 757424007918 Q-loop/lid; other site 757424007919 ABC transporter signature motif; other site 757424007920 Walker B; other site 757424007921 D-loop; other site 757424007922 H-loop/switch region; other site 757424007923 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424007924 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424007925 Walker A/P-loop; other site 757424007926 ATP binding site [chemical binding]; other site 757424007927 Q-loop/lid; other site 757424007928 ABC transporter signature motif; other site 757424007929 Walker B; other site 757424007930 D-loop; other site 757424007931 H-loop/switch region; other site 757424007932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424007933 TM-ABC transporter signature motif; other site 757424007934 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424007935 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424007936 TM-ABC transporter signature motif; other site 757424007937 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424007938 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 757424007939 putative ligand binding site [chemical binding]; other site 757424007940 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 757424007941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007942 active site 757424007943 phosphorylation site [posttranslational modification] 757424007944 intermolecular recognition site; other site 757424007945 dimerization interface [polypeptide binding]; other site 757424007946 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424007947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424007948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 757424007949 dimer interface [polypeptide binding]; other site 757424007950 phosphorylation site [posttranslational modification] 757424007951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007952 ATP binding site [chemical binding]; other site 757424007953 Mg2+ binding site [ion binding]; other site 757424007954 G-X-G motif; other site 757424007955 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 757424007956 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 757424007957 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 757424007958 Subunit I/III interface [polypeptide binding]; other site 757424007959 Subunit III/IV interface [polypeptide binding]; other site 757424007960 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 757424007961 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 757424007962 D-pathway; other site 757424007963 Putative ubiquinol binding site [chemical binding]; other site 757424007964 Low-spin heme (heme b) binding site [chemical binding]; other site 757424007965 Putative water exit pathway; other site 757424007966 Binuclear center (heme o3/CuB) [ion binding]; other site 757424007967 K-pathway; other site 757424007968 Putative proton exit pathway; other site 757424007969 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 757424007970 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 757424007971 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 757424007972 metabolite-proton symporter; Region: 2A0106; TIGR00883 757424007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424007974 putative substrate translocation pore; other site 757424007975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 757424007976 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 757424007977 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 757424007978 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 757424007979 putative Cl- selectivity filter; other site 757424007980 putative pore gating glutamate residue; other site 757424007981 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 757424007982 Response regulator receiver domain; Region: Response_reg; pfam00072 757424007983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424007984 active site 757424007985 phosphorylation site [posttranslational modification] 757424007986 intermolecular recognition site; other site 757424007987 dimerization interface [polypeptide binding]; other site 757424007988 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 757424007989 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424007990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424007991 dimerization interface [polypeptide binding]; other site 757424007992 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424007993 putative binding surface; other site 757424007994 active site 757424007995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424007996 ATP binding site [chemical binding]; other site 757424007997 Mg2+ binding site [ion binding]; other site 757424007998 G-X-G motif; other site 757424007999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 757424008000 classical (c) SDRs; Region: SDR_c; cd05233 757424008001 NAD(P) binding site [chemical binding]; other site 757424008002 active site 757424008003 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 757424008004 putative active site [active] 757424008005 catalytic site [active] 757424008006 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 757424008007 PLD-like domain; Region: PLDc_2; pfam13091 757424008008 putative active site [active] 757424008009 catalytic site [active] 757424008010 Uncharacterized conserved protein [Function unknown]; Region: COG0398 757424008011 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 757424008012 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 757424008013 putative catalytic site [active] 757424008014 putative metal binding site [ion binding]; other site 757424008015 putative phosphate binding site [ion binding]; other site 757424008016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424008017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424008018 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 757424008019 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 757424008020 Catalytic site [active] 757424008021 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 757424008022 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424008023 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424008024 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424008025 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 757424008026 Protein export membrane protein; Region: SecD_SecF; cl14618 757424008027 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 757424008028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008029 active site 757424008030 phosphorylation site [posttranslational modification] 757424008031 intermolecular recognition site; other site 757424008032 dimerization interface [polypeptide binding]; other site 757424008033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424008034 DNA binding site [nucleotide binding] 757424008035 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 757424008036 HAMP domain; Region: HAMP; pfam00672 757424008037 dimerization interface [polypeptide binding]; other site 757424008038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008039 dimer interface [polypeptide binding]; other site 757424008040 phosphorylation site [posttranslational modification] 757424008041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008042 ATP binding site [chemical binding]; other site 757424008043 Mg2+ binding site [ion binding]; other site 757424008044 G-X-G motif; other site 757424008045 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 757424008046 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 757424008047 putative ligand binding site [chemical binding]; other site 757424008048 NAD binding site [chemical binding]; other site 757424008049 dimerization interface [polypeptide binding]; other site 757424008050 catalytic site [active] 757424008051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424008052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 757424008053 putative metal binding site [ion binding]; other site 757424008054 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 757424008055 Ligand Binding Site [chemical binding]; other site 757424008056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 757424008057 Ligand Binding Site [chemical binding]; other site 757424008058 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 757424008059 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 757424008060 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 757424008061 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 757424008062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 757424008063 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 757424008064 putative active site [active] 757424008065 heme pocket [chemical binding]; other site 757424008066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424008067 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 757424008068 putative active site [active] 757424008069 heme pocket [chemical binding]; other site 757424008070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424008071 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 757424008072 putative active site [active] 757424008073 heme pocket [chemical binding]; other site 757424008074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008075 dimer interface [polypeptide binding]; other site 757424008076 phosphorylation site [posttranslational modification] 757424008077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008078 ATP binding site [chemical binding]; other site 757424008079 Mg2+ binding site [ion binding]; other site 757424008080 G-X-G motif; other site 757424008081 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424008082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008083 active site 757424008084 phosphorylation site [posttranslational modification] 757424008085 intermolecular recognition site; other site 757424008086 dimerization interface [polypeptide binding]; other site 757424008087 Response regulator receiver domain; Region: Response_reg; pfam00072 757424008088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008089 active site 757424008090 phosphorylation site [posttranslational modification] 757424008091 intermolecular recognition site; other site 757424008092 dimerization interface [polypeptide binding]; other site 757424008093 large tegument protein UL36; Provisional; Region: PHA03247 757424008094 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 757424008095 GAF domain; Region: GAF; pfam01590 757424008096 Phytochrome region; Region: PHY; pfam00360 757424008097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008098 dimer interface [polypeptide binding]; other site 757424008099 phosphorylation site [posttranslational modification] 757424008100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008101 ATP binding site [chemical binding]; other site 757424008102 Mg2+ binding site [ion binding]; other site 757424008103 G-X-G motif; other site 757424008104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424008105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008106 dimer interface [polypeptide binding]; other site 757424008107 phosphorylation site [posttranslational modification] 757424008108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008109 ATP binding site [chemical binding]; other site 757424008110 Mg2+ binding site [ion binding]; other site 757424008111 G-X-G motif; other site 757424008112 Response regulator receiver domain; Region: Response_reg; pfam00072 757424008113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008114 active site 757424008115 phosphorylation site [posttranslational modification] 757424008116 intermolecular recognition site; other site 757424008117 dimerization interface [polypeptide binding]; other site 757424008118 CHASE3 domain; Region: CHASE3; pfam05227 757424008119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424008120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424008121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008122 ATP binding site [chemical binding]; other site 757424008123 Mg2+ binding site [ion binding]; other site 757424008124 G-X-G motif; other site 757424008125 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 757424008126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 757424008127 active site 757424008128 dimer interface [polypeptide binding]; other site 757424008129 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 757424008130 dimer interface [polypeptide binding]; other site 757424008131 active site 757424008132 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 757424008133 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 757424008134 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 757424008135 active site 757424008136 catalytic site [active] 757424008137 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 757424008138 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 757424008139 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 757424008140 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 757424008141 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 757424008142 catalytic site [active] 757424008143 active site 757424008144 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 757424008145 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 757424008146 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 757424008147 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 757424008148 active site 757424008149 catalytic site [active] 757424008150 glycogen branching enzyme; Provisional; Region: PRK05402 757424008151 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 757424008152 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 757424008153 active site 757424008154 catalytic site [active] 757424008155 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 757424008156 glycogen synthase; Provisional; Region: glgA; PRK00654 757424008157 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 757424008158 ADP-binding pocket [chemical binding]; other site 757424008159 homodimer interface [polypeptide binding]; other site 757424008160 Dodecin; Region: Dodecin; pfam07311 757424008161 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 757424008162 GAF domain; Region: GAF; pfam01590 757424008163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424008164 Walker A motif; other site 757424008165 ATP binding site [chemical binding]; other site 757424008166 Walker B motif; other site 757424008167 arginine finger; other site 757424008168 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424008169 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 757424008170 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 757424008171 heme-binding site [chemical binding]; other site 757424008172 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 757424008173 FAD binding pocket [chemical binding]; other site 757424008174 FAD binding motif [chemical binding]; other site 757424008175 phosphate binding motif [ion binding]; other site 757424008176 beta-alpha-beta structure motif; other site 757424008177 NAD binding pocket [chemical binding]; other site 757424008178 Heme binding pocket [chemical binding]; other site 757424008179 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 757424008180 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 757424008181 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 757424008182 putative ligand binding site [chemical binding]; other site 757424008183 putative NAD binding site [chemical binding]; other site 757424008184 catalytic site [active] 757424008185 citrate-proton symporter; Provisional; Region: PRK15075 757424008186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424008187 putative substrate translocation pore; other site 757424008188 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 757424008189 toxin interface [polypeptide binding]; other site 757424008190 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 757424008191 Zn binding site [ion binding]; other site 757424008192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424008193 non-specific DNA binding site [nucleotide binding]; other site 757424008194 salt bridge; other site 757424008195 sequence-specific DNA binding site [nucleotide binding]; other site 757424008196 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 757424008197 peptide binding site [polypeptide binding]; other site 757424008198 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 757424008199 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 757424008200 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 757424008201 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 757424008202 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 757424008203 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 757424008204 ethanolamine permease; Region: 2A0305; TIGR00908 757424008205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424008206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424008207 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424008208 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 757424008209 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424008210 NMT1-like family; Region: NMT1_2; pfam13379 757424008211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424008212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424008213 putative PBP binding loops; other site 757424008214 dimer interface [polypeptide binding]; other site 757424008215 ABC-ATPase subunit interface; other site 757424008216 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424008217 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424008218 Walker A/P-loop; other site 757424008219 ATP binding site [chemical binding]; other site 757424008220 Q-loop/lid; other site 757424008221 ABC transporter signature motif; other site 757424008222 Walker B; other site 757424008223 D-loop; other site 757424008224 H-loop/switch region; other site 757424008225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424008226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008227 active site 757424008228 phosphorylation site [posttranslational modification] 757424008229 intermolecular recognition site; other site 757424008230 dimerization interface [polypeptide binding]; other site 757424008231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424008232 DNA binding site [nucleotide binding] 757424008233 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424008234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424008235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424008236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008237 dimer interface [polypeptide binding]; other site 757424008238 phosphorylation site [posttranslational modification] 757424008239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008240 ATP binding site [chemical binding]; other site 757424008241 Mg2+ binding site [ion binding]; other site 757424008242 G-X-G motif; other site 757424008243 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 757424008244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424008245 S-adenosylmethionine binding site [chemical binding]; other site 757424008246 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 757424008247 Pirin-related protein [General function prediction only]; Region: COG1741 757424008248 Pirin; Region: Pirin; pfam02678 757424008249 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 757424008250 Pirin-related protein [General function prediction only]; Region: COG1741 757424008251 Pirin; Region: Pirin; pfam02678 757424008252 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 757424008253 Predicted membrane protein [Function unknown]; Region: COG2259 757424008254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424008255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424008256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424008257 dimerization interface [polypeptide binding]; other site 757424008258 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 757424008259 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 757424008260 conserved cys residue [active] 757424008261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424008262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424008263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424008264 putative substrate translocation pore; other site 757424008265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424008266 Isochorismatase family; Region: Isochorismatase; pfam00857 757424008267 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 757424008268 catalytic triad [active] 757424008269 conserved cis-peptide bond; other site 757424008270 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 757424008271 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 757424008272 ligand binding site [chemical binding]; other site 757424008273 flexible hinge region; other site 757424008274 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 757424008275 putative switch regulator; other site 757424008276 non-specific DNA interactions [nucleotide binding]; other site 757424008277 DNA binding site [nucleotide binding] 757424008278 sequence specific DNA binding site [nucleotide binding]; other site 757424008279 putative cAMP binding site [chemical binding]; other site 757424008280 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 757424008281 active site 757424008282 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 757424008283 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 757424008284 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 757424008285 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 757424008286 active site 757424008287 metal binding site [ion binding]; metal-binding site 757424008288 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 757424008289 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 757424008290 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 757424008291 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 757424008292 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 757424008293 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 757424008294 putative GTP cyclohydrolase; Provisional; Region: PRK13674 757424008295 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 757424008296 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 757424008297 active site 757424008298 Zn binding site [ion binding]; other site 757424008299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424008300 Coenzyme A binding pocket [chemical binding]; other site 757424008301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424008302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 757424008303 Coenzyme A binding pocket [chemical binding]; other site 757424008304 enoyl-CoA hydratase; Provisional; Region: PRK09076 757424008305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424008306 substrate binding site [chemical binding]; other site 757424008307 oxyanion hole (OAH) forming residues; other site 757424008308 trimer interface [polypeptide binding]; other site 757424008309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424008310 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 757424008311 substrate binding pocket [chemical binding]; other site 757424008312 FAD binding site [chemical binding]; other site 757424008313 catalytic base [active] 757424008314 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 757424008315 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 757424008316 dimer interface [polypeptide binding]; other site 757424008317 PYR/PP interface [polypeptide binding]; other site 757424008318 TPP binding site [chemical binding]; other site 757424008319 substrate binding site [chemical binding]; other site 757424008320 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 757424008321 TPP-binding site; other site 757424008322 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 757424008323 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 757424008324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424008325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424008326 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 757424008327 putative effector binding pocket; other site 757424008328 putative dimerization interface [polypeptide binding]; other site 757424008329 short chain dehydrogenase; Provisional; Region: PRK12939 757424008330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424008331 NAD(P) binding site [chemical binding]; other site 757424008332 active site 757424008333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424008334 substrate binding pocket [chemical binding]; other site 757424008335 membrane-bound complex binding site; other site 757424008336 hinge residues; other site 757424008337 CHASE domain; Region: CHASE; pfam03924 757424008338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424008339 PAS domain; Region: PAS_9; pfam13426 757424008340 putative active site [active] 757424008341 heme pocket [chemical binding]; other site 757424008342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424008343 PAS domain; Region: PAS_9; pfam13426 757424008344 putative active site [active] 757424008345 heme pocket [chemical binding]; other site 757424008346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424008347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424008348 metal binding site [ion binding]; metal-binding site 757424008349 active site 757424008350 I-site; other site 757424008351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424008352 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424008353 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 757424008354 C-terminal domain interface [polypeptide binding]; other site 757424008355 GSH binding site (G-site) [chemical binding]; other site 757424008356 dimer interface [polypeptide binding]; other site 757424008357 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 757424008358 dimer interface [polypeptide binding]; other site 757424008359 N-terminal domain interface [polypeptide binding]; other site 757424008360 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 757424008361 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 757424008362 aminotransferase; Validated; Region: PRK08175 757424008363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424008364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424008365 homodimer interface [polypeptide binding]; other site 757424008366 catalytic residue [active] 757424008367 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 757424008368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424008369 acyl-activating enzyme (AAE) consensus motif; other site 757424008370 AMP binding site [chemical binding]; other site 757424008371 active site 757424008372 CoA binding site [chemical binding]; other site 757424008373 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424008374 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424008375 Walker A/P-loop; other site 757424008376 ATP binding site [chemical binding]; other site 757424008377 Q-loop/lid; other site 757424008378 ABC transporter signature motif; other site 757424008379 Walker B; other site 757424008380 D-loop; other site 757424008381 H-loop/switch region; other site 757424008382 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 757424008383 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424008384 putative ligand binding site [chemical binding]; other site 757424008385 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424008386 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424008387 TM-ABC transporter signature motif; other site 757424008388 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424008389 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424008390 TM-ABC transporter signature motif; other site 757424008391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424008392 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424008393 Walker A/P-loop; other site 757424008394 ATP binding site [chemical binding]; other site 757424008395 Q-loop/lid; other site 757424008396 ABC transporter signature motif; other site 757424008397 Walker B; other site 757424008398 D-loop; other site 757424008399 H-loop/switch region; other site 757424008400 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 757424008401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424008402 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 757424008403 acyl-activating enzyme (AAE) consensus motif; other site 757424008404 putative AMP binding site [chemical binding]; other site 757424008405 putative active site [active] 757424008406 putative CoA binding site [chemical binding]; other site 757424008407 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 757424008408 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 757424008409 ligand binding site [chemical binding]; other site 757424008410 flexible hinge region; other site 757424008411 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 757424008412 putative switch regulator; other site 757424008413 non-specific DNA interactions [nucleotide binding]; other site 757424008414 DNA binding site [nucleotide binding] 757424008415 sequence specific DNA binding site [nucleotide binding]; other site 757424008416 putative cAMP binding site [chemical binding]; other site 757424008417 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424008418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008419 active site 757424008420 phosphorylation site [posttranslational modification] 757424008421 intermolecular recognition site; other site 757424008422 dimerization interface [polypeptide binding]; other site 757424008423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424008424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008425 active site 757424008426 phosphorylation site [posttranslational modification] 757424008427 intermolecular recognition site; other site 757424008428 dimerization interface [polypeptide binding]; other site 757424008429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424008430 DNA binding residues [nucleotide binding] 757424008431 dimerization interface [polypeptide binding]; other site 757424008432 Response regulator receiver domain; Region: Response_reg; pfam00072 757424008433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008434 active site 757424008435 phosphorylation site [posttranslational modification] 757424008436 intermolecular recognition site; other site 757424008437 PAS domain; Region: PAS; smart00091 757424008438 PAS fold; Region: PAS_4; pfam08448 757424008439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 757424008440 Histidine kinase; Region: HisKA_3; pfam07730 757424008441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008442 ATP binding site [chemical binding]; other site 757424008443 Mg2+ binding site [ion binding]; other site 757424008444 G-X-G motif; other site 757424008445 CHASE3 domain; Region: CHASE3; pfam05227 757424008446 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 757424008447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424008448 putative active site [active] 757424008449 heme pocket [chemical binding]; other site 757424008450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008451 dimer interface [polypeptide binding]; other site 757424008452 phosphorylation site [posttranslational modification] 757424008453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008454 ATP binding site [chemical binding]; other site 757424008455 Mg2+ binding site [ion binding]; other site 757424008456 G-X-G motif; other site 757424008457 Spore Coat Protein U domain; Region: SCPU; pfam05229 757424008458 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 757424008459 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 757424008460 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 757424008461 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 757424008462 PapC C-terminal domain; Region: PapC_C; pfam13953 757424008463 Spore Coat Protein U domain; Region: SCPU; pfam05229 757424008464 Uncharacterized secreted protein [Function unknown]; Region: COG5430 757424008465 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 757424008466 Found in ATP-dependent protease La (LON); Region: LON; smart00464 757424008467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424008468 Walker A motif; other site 757424008469 ATP binding site [chemical binding]; other site 757424008470 Walker B motif; other site 757424008471 arginine finger; other site 757424008472 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 757424008473 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 757424008474 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 757424008475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424008476 Walker A motif; other site 757424008477 ATP binding site [chemical binding]; other site 757424008478 Walker B motif; other site 757424008479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 757424008480 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 757424008481 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 757424008482 oligomer interface [polypeptide binding]; other site 757424008483 active site residues [active] 757424008484 trigger factor; Provisional; Region: tig; PRK01490 757424008485 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 757424008486 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 757424008487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 757424008488 CreA protein; Region: CreA; pfam05981 757424008489 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 757424008490 cell division protein DamX; Validated; Region: PRK10905 757424008491 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 757424008492 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 757424008493 short chain dehydrogenase; Provisional; Region: PRK07478 757424008494 classical (c) SDRs; Region: SDR_c; cd05233 757424008495 NAD(P) binding site [chemical binding]; other site 757424008496 active site 757424008497 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 757424008498 active site lid residues [active] 757424008499 substrate binding pocket [chemical binding]; other site 757424008500 catalytic residues [active] 757424008501 substrate-Mg2+ binding site; other site 757424008502 aspartate-rich region 1; other site 757424008503 aspartate-rich region 2; other site 757424008504 HDOD domain; Region: HDOD; pfam08668 757424008505 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 757424008506 active site lid residues [active] 757424008507 substrate binding pocket [chemical binding]; other site 757424008508 catalytic residues [active] 757424008509 substrate-Mg2+ binding site; other site 757424008510 aspartate-rich region 1; other site 757424008511 aspartate-rich region 2; other site 757424008512 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 757424008513 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 757424008514 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 757424008515 phosphate binding site [ion binding]; other site 757424008516 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 757424008517 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 757424008518 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 757424008519 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 757424008520 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 757424008521 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 757424008522 active site 757424008523 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 757424008524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008525 active site 757424008526 phosphorylation site [posttranslational modification] 757424008527 intermolecular recognition site; other site 757424008528 dimerization interface [polypeptide binding]; other site 757424008529 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424008530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424008531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008532 ATP binding site [chemical binding]; other site 757424008533 Mg2+ binding site [ion binding]; other site 757424008534 G-X-G motif; other site 757424008535 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424008536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424008537 N-terminal plug; other site 757424008538 ligand-binding site [chemical binding]; other site 757424008539 DNA polymerase III subunit delta'; Validated; Region: PRK06964 757424008540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 757424008541 Walker A motif; other site 757424008542 ATP binding site [chemical binding]; other site 757424008543 thymidylate kinase; Validated; Region: tmk; PRK00698 757424008544 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 757424008545 TMP-binding site; other site 757424008546 ATP-binding site [chemical binding]; other site 757424008547 YceG-like family; Region: YceG; pfam02618 757424008548 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 757424008549 dimerization interface [polypeptide binding]; other site 757424008550 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 757424008551 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 757424008552 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 757424008553 NRDE protein; Region: NRDE; cl01315 757424008554 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 757424008555 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 757424008556 putative active site [active] 757424008557 catalytic site [active] 757424008558 putative metal binding site [ion binding]; other site 757424008559 oligomer interface [polypeptide binding]; other site 757424008560 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 757424008561 Phosphoesterase family; Region: Phosphoesterase; pfam04185 757424008562 Domain of unknown function (DUF756); Region: DUF756; pfam05506 757424008563 Domain of unknown function (DUF756); Region: DUF756; pfam05506 757424008564 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 757424008565 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424008566 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 757424008567 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 757424008568 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 757424008569 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 757424008570 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 757424008571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 757424008573 DNA binding site [nucleotide binding] 757424008574 domain linker motif; other site 757424008575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 757424008576 ligand binding site [chemical binding]; other site 757424008577 dimerization interface [polypeptide binding]; other site 757424008578 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424008579 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424008580 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 757424008581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424008582 dimer interface [polypeptide binding]; other site 757424008583 ABC-ATPase subunit interface; other site 757424008584 putative PBP binding loops; other site 757424008585 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424008586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424008587 putative PBP binding loops; other site 757424008588 ABC-ATPase subunit interface; other site 757424008589 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 757424008590 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 757424008591 potential catalytic triad [active] 757424008592 conserved cys residue [active] 757424008593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424008594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424008595 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424008596 putative effector binding pocket; other site 757424008597 dimerization interface [polypeptide binding]; other site 757424008598 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 757424008599 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 757424008600 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 757424008601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424008602 dimer interface [polypeptide binding]; other site 757424008603 putative CheW interface [polypeptide binding]; other site 757424008604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 757424008605 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 757424008606 CoenzymeA binding site [chemical binding]; other site 757424008607 subunit interaction site [polypeptide binding]; other site 757424008608 PHB binding site; other site 757424008609 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 757424008610 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 757424008611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424008612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424008613 dimerization interface [polypeptide binding]; other site 757424008614 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 757424008615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424008616 motif II; other site 757424008617 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 757424008618 HDOD domain; Region: HDOD; pfam08668 757424008619 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 757424008620 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 757424008621 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 757424008622 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 757424008623 multimer interface [polypeptide binding]; other site 757424008624 active site 757424008625 catalytic triad [active] 757424008626 dimer interface [polypeptide binding]; other site 757424008627 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 757424008628 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424008629 Walker A/P-loop; other site 757424008630 ATP binding site [chemical binding]; other site 757424008631 Q-loop/lid; other site 757424008632 ABC transporter signature motif; other site 757424008633 Walker B; other site 757424008634 D-loop; other site 757424008635 H-loop/switch region; other site 757424008636 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 757424008637 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424008638 Walker A/P-loop; other site 757424008639 ATP binding site [chemical binding]; other site 757424008640 Q-loop/lid; other site 757424008641 ABC transporter signature motif; other site 757424008642 Walker B; other site 757424008643 D-loop; other site 757424008644 H-loop/switch region; other site 757424008645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424008646 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424008647 TM-ABC transporter signature motif; other site 757424008648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424008649 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424008650 TM-ABC transporter signature motif; other site 757424008651 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424008652 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 757424008653 putative ligand binding site [chemical binding]; other site 757424008654 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 757424008655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424008656 dimer interface [polypeptide binding]; other site 757424008657 phosphorylation site [posttranslational modification] 757424008658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008659 ATP binding site [chemical binding]; other site 757424008660 Mg2+ binding site [ion binding]; other site 757424008661 G-X-G motif; other site 757424008662 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424008663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008664 active site 757424008665 phosphorylation site [posttranslational modification] 757424008666 intermolecular recognition site; other site 757424008667 dimerization interface [polypeptide binding]; other site 757424008668 Response regulator receiver domain; Region: Response_reg; pfam00072 757424008669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008670 active site 757424008671 phosphorylation site [posttranslational modification] 757424008672 intermolecular recognition site; other site 757424008673 dimerization interface [polypeptide binding]; other site 757424008674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424008675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424008676 DNA binding residues [nucleotide binding] 757424008677 dimerization interface [polypeptide binding]; other site 757424008678 hypothetical protein; Provisional; Region: PRK07588 757424008679 hypothetical protein; Provisional; Region: PRK07236 757424008680 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424008681 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424008682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424008683 N-terminal plug; other site 757424008684 ligand-binding site [chemical binding]; other site 757424008685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424008686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424008687 cobyric acid synthase; Provisional; Region: PRK00784 757424008688 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 757424008689 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 757424008690 catalytic triad [active] 757424008691 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 757424008692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424008693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424008694 homodimer interface [polypeptide binding]; other site 757424008695 catalytic residue [active] 757424008696 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 757424008697 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 757424008698 homotrimer interface [polypeptide binding]; other site 757424008699 Walker A motif; other site 757424008700 GTP binding site [chemical binding]; other site 757424008701 Walker B motif; other site 757424008702 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 757424008703 putative FMN binding site [chemical binding]; other site 757424008704 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 757424008705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 757424008706 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 757424008707 catalytic triad [active] 757424008708 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 757424008709 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 757424008710 Walker A motif; other site 757424008711 homodimer interface [polypeptide binding]; other site 757424008712 ATP binding site [chemical binding]; other site 757424008713 hydroxycobalamin binding site [chemical binding]; other site 757424008714 Walker B motif; other site 757424008715 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 757424008716 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424008717 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 757424008718 active site 757424008719 SAM binding site [chemical binding]; other site 757424008720 homodimer interface [polypeptide binding]; other site 757424008721 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 757424008722 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 757424008723 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 757424008724 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 757424008725 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 757424008726 active site 757424008727 SAM binding site [chemical binding]; other site 757424008728 homodimer interface [polypeptide binding]; other site 757424008729 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 757424008730 active site 757424008731 SAM binding site [chemical binding]; other site 757424008732 homodimer interface [polypeptide binding]; other site 757424008733 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 757424008734 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 757424008735 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 757424008736 putative active site [active] 757424008737 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 757424008738 putative active site [active] 757424008739 Precorrin-8X methylmutase; Region: CbiC; pfam02570 757424008740 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 757424008741 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 757424008742 active site 757424008743 putative homodimer interface [polypeptide binding]; other site 757424008744 SAM binding site [chemical binding]; other site 757424008745 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 757424008746 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 757424008747 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 757424008748 metal ion-dependent adhesion site (MIDAS); other site 757424008749 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 757424008750 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 757424008751 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 757424008752 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 757424008753 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 757424008754 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 757424008755 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424008756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424008757 dimerization interface [polypeptide binding]; other site 757424008758 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424008759 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424008760 dimer interface [polypeptide binding]; other site 757424008761 putative CheW interface [polypeptide binding]; other site 757424008762 phosphoglucomutase; Validated; Region: PRK07564 757424008763 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 757424008764 active site 757424008765 substrate binding site [chemical binding]; other site 757424008766 metal binding site [ion binding]; metal-binding site 757424008767 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 757424008768 tetramer interface; other site 757424008769 active site 757424008770 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 757424008771 MOSC domain; Region: MOSC; pfam03473 757424008772 Predicted integral membrane protein [Function unknown]; Region: COG5615 757424008773 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 757424008774 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424008775 HAMP domain; Region: HAMP; pfam00672 757424008776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424008777 dimer interface [polypeptide binding]; other site 757424008778 putative CheW interface [polypeptide binding]; other site 757424008779 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 757424008780 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 757424008781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424008782 Zn2+ binding site [ion binding]; other site 757424008783 Mg2+ binding site [ion binding]; other site 757424008784 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 757424008785 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 757424008786 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 757424008787 putative ligand binding site [chemical binding]; other site 757424008788 NAD binding site [chemical binding]; other site 757424008789 catalytic site [active] 757424008790 Acyl transferase domain; Region: Acyl_transf_1; cl08282 757424008791 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 757424008792 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 757424008793 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 757424008794 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 757424008795 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 757424008796 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 757424008797 Coenzyme A transferase; Region: CoA_trans; cl17247 757424008798 DctM-like transporters; Region: DctM; pfam06808 757424008799 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 757424008800 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 757424008801 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 757424008802 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424008803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424008804 DNA-binding site [nucleotide binding]; DNA binding site 757424008805 FCD domain; Region: FCD; pfam07729 757424008806 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 757424008807 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 757424008808 active site 757424008809 HipA N-terminal domain; Region: Couple_hipA; pfam13657 757424008810 HipA-like N-terminal domain; Region: HipA_N; pfam07805 757424008811 HipA-like C-terminal domain; Region: HipA_C; pfam07804 757424008812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424008813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424008814 non-specific DNA binding site [nucleotide binding]; other site 757424008815 salt bridge; other site 757424008816 sequence-specific DNA binding site [nucleotide binding]; other site 757424008817 Putative motility protein; Region: YjfB_motility; pfam14070 757424008818 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 757424008819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 757424008820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424008821 non-specific DNA binding site [nucleotide binding]; other site 757424008822 salt bridge; other site 757424008823 sequence-specific DNA binding site [nucleotide binding]; other site 757424008824 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 757424008825 RNA polymerase sigma factor; Provisional; Region: PRK12511 757424008826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424008827 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 757424008828 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 757424008829 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 757424008830 apolar tunnel; other site 757424008831 heme binding site [chemical binding]; other site 757424008832 dimerization interface [polypeptide binding]; other site 757424008833 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 757424008834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424008835 dimerization interface [polypeptide binding]; other site 757424008836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424008837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424008838 metal binding site [ion binding]; metal-binding site 757424008839 active site 757424008840 I-site; other site 757424008841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424008842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424008843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424008844 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424008845 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 757424008846 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424008847 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 757424008848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424008849 putative substrate translocation pore; other site 757424008850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424008851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424008852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424008853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424008854 dimerization interface [polypeptide binding]; other site 757424008855 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424008856 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424008857 active site 757424008858 catalytic tetrad [active] 757424008859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 757424008860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 757424008861 PAAR motif; Region: PAAR_motif; pfam05488 757424008862 S-formylglutathione hydrolase; Region: PLN02442 757424008863 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 757424008864 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 757424008865 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 757424008866 substrate binding site [chemical binding]; other site 757424008867 catalytic Zn binding site [ion binding]; other site 757424008868 NAD binding site [chemical binding]; other site 757424008869 structural Zn binding site [ion binding]; other site 757424008870 dimer interface [polypeptide binding]; other site 757424008871 PAS domain; Region: PAS_8; pfam13188 757424008872 PAS domain; Region: PAS_9; pfam13426 757424008873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424008874 GAF domain; Region: GAF; pfam01590 757424008875 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424008876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424008877 metal binding site [ion binding]; metal-binding site 757424008878 active site 757424008879 I-site; other site 757424008880 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424008881 enterobactin exporter EntS; Provisional; Region: PRK10489 757424008882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424008883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424008884 active site 757424008885 catalytic tetrad [active] 757424008886 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 757424008887 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 757424008888 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 757424008889 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 757424008890 PhnA protein; Region: PhnA; pfam03831 757424008891 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 757424008892 4Fe-4S binding domain; Region: Fer4_5; pfam12801 757424008893 Iron permease FTR1 family; Region: FTR1; cl00475 757424008894 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 757424008895 Fe2+ transport protein; Region: Iron_transport; pfam10634 757424008896 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424008897 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 757424008898 dimerization interface [polypeptide binding]; other site 757424008899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424008900 dimer interface [polypeptide binding]; other site 757424008901 putative CheW interface [polypeptide binding]; other site 757424008902 Patatin-like phospholipase; Region: Patatin; pfam01734 757424008903 active site 757424008904 nucleophile elbow; other site 757424008905 Response regulator receiver domain; Region: Response_reg; pfam00072 757424008906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008907 active site 757424008908 phosphorylation site [posttranslational modification] 757424008909 intermolecular recognition site; other site 757424008910 dimerization interface [polypeptide binding]; other site 757424008911 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424008912 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424008913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424008914 dimerization interface [polypeptide binding]; other site 757424008915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424008916 dimer interface [polypeptide binding]; other site 757424008917 putative CheW interface [polypeptide binding]; other site 757424008918 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424008919 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 757424008920 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 757424008921 dimer interface [polypeptide binding]; other site 757424008922 active site 757424008923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424008924 catalytic residues [active] 757424008925 substrate binding site [chemical binding]; other site 757424008926 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 757424008927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424008928 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 757424008929 putative AMP binding site [chemical binding]; other site 757424008930 putative active site [active] 757424008931 acyl-activating enzyme (AAE) consensus motif; other site 757424008932 putative CoA binding site [chemical binding]; other site 757424008933 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 757424008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424008935 active site 757424008936 phosphorylation site [posttranslational modification] 757424008937 intermolecular recognition site; other site 757424008938 dimerization interface [polypeptide binding]; other site 757424008939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424008940 Walker A motif; other site 757424008941 ATP binding site [chemical binding]; other site 757424008942 Walker B motif; other site 757424008943 arginine finger; other site 757424008944 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424008945 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 757424008946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424008947 ATP binding site [chemical binding]; other site 757424008948 Mg2+ binding site [ion binding]; other site 757424008949 G-X-G motif; other site 757424008950 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 757424008951 Bacterial sugar transferase; Region: Bac_transf; pfam02397 757424008952 Uncharacterized conserved protein [Function unknown]; Region: COG1434 757424008953 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 757424008954 putative active site [active] 757424008955 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 757424008956 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 757424008957 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 757424008958 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 757424008959 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 757424008960 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 757424008961 NAD binding site [chemical binding]; other site 757424008962 substrate binding site [chemical binding]; other site 757424008963 homodimer interface [polypeptide binding]; other site 757424008964 active site 757424008965 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 757424008966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 757424008967 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 757424008968 Chain length determinant protein; Region: Wzz; pfam02706 757424008969 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 757424008970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424008971 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 757424008972 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 757424008973 AAA ATPase domain; Region: AAA_16; pfam13191 757424008974 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 757424008975 active site 757424008976 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 757424008977 homodimer interface [polypeptide binding]; other site 757424008978 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 757424008979 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 757424008980 putative active site [active] 757424008981 putative catalytic site [active] 757424008982 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 757424008983 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 757424008984 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 757424008985 exosortase A; Region: exosortase_1; TIGR03109 757424008986 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 757424008987 EpsI family protein; Region: EpsI_fam; TIGR02914 757424008988 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 757424008989 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 757424008990 putative ADP-binding pocket [chemical binding]; other site 757424008991 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 757424008992 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 757424008993 active site 757424008994 dimer interface [polypeptide binding]; other site 757424008995 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 757424008996 Ligand Binding Site [chemical binding]; other site 757424008997 Molecular Tunnel; other site 757424008998 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 757424008999 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 757424009000 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 757424009001 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 757424009002 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 757424009003 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 757424009004 putative active site [active] 757424009005 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424009006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424009007 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 757424009008 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 757424009009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 757424009010 binding surface 757424009011 TPR motif; other site 757424009012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009013 TPR motif; other site 757424009014 binding surface 757424009015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009016 binding surface 757424009017 TPR motif; other site 757424009018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009019 binding surface 757424009020 TPR motif; other site 757424009021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009022 TPR motif; other site 757424009023 binding surface 757424009024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009025 TPR motif; other site 757424009026 binding surface 757424009027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009028 binding surface 757424009029 TPR motif; other site 757424009030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009031 binding surface 757424009032 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 757424009033 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 757424009034 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424009035 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 757424009036 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 757424009037 O-Antigen ligase; Region: Wzy_C; cl04850 757424009038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424009039 ATP binding site [chemical binding]; other site 757424009040 Mg2+ binding site [ion binding]; other site 757424009041 G-X-G motif; other site 757424009042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424009043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009044 active site 757424009045 phosphorylation site [posttranslational modification] 757424009046 intermolecular recognition site; other site 757424009047 dimerization interface [polypeptide binding]; other site 757424009048 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424009049 DNA binding residues [nucleotide binding] 757424009050 dimerization interface [polypeptide binding]; other site 757424009051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424009052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424009053 metal binding site [ion binding]; metal-binding site 757424009054 active site 757424009055 I-site; other site 757424009056 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 757424009057 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 757424009058 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 757424009059 enolase; Provisional; Region: eno; PRK00077 757424009060 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 757424009061 dimer interface [polypeptide binding]; other site 757424009062 metal binding site [ion binding]; metal-binding site 757424009063 substrate binding pocket [chemical binding]; other site 757424009064 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 757424009065 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 757424009066 CTP synthetase; Validated; Region: pyrG; PRK05380 757424009067 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 757424009068 Catalytic site [active] 757424009069 active site 757424009070 UTP binding site [chemical binding]; other site 757424009071 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 757424009072 active site 757424009073 putative oxyanion hole; other site 757424009074 catalytic triad [active] 757424009075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424009076 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 757424009077 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 757424009078 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 757424009079 Competence protein; Region: Competence; pfam03772 757424009080 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424009081 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 757424009082 active site 757424009083 acetylornithine deacetylase; Provisional; Region: PRK07522 757424009084 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 757424009085 metal binding site [ion binding]; metal-binding site 757424009086 putative dimer interface [polypeptide binding]; other site 757424009087 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 757424009088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424009089 Walker A/P-loop; other site 757424009090 ATP binding site [chemical binding]; other site 757424009091 Q-loop/lid; other site 757424009092 ABC transporter signature motif; other site 757424009093 Walker B; other site 757424009094 D-loop; other site 757424009095 H-loop/switch region; other site 757424009096 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 757424009097 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 757424009098 FtsX-like permease family; Region: FtsX; pfam02687 757424009099 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 757424009100 Part of AAA domain; Region: AAA_19; pfam13245 757424009101 Family description; Region: UvrD_C_2; pfam13538 757424009102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 757424009103 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 757424009104 DHH family; Region: DHH; pfam01368 757424009105 DHHA1 domain; Region: DHHA1; pfam02272 757424009106 Cache domain; Region: Cache_1; pfam02743 757424009107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424009108 dimerization interface [polypeptide binding]; other site 757424009109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424009110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424009111 metal binding site [ion binding]; metal-binding site 757424009112 active site 757424009113 I-site; other site 757424009114 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 757424009115 peptide chain release factor 2; Validated; Region: prfB; PRK00578 757424009116 This domain is found in peptide chain release factors; Region: PCRF; smart00937 757424009117 RF-1 domain; Region: RF-1; pfam00472 757424009118 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 757424009119 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 757424009120 dimer interface [polypeptide binding]; other site 757424009121 putative anticodon binding site; other site 757424009122 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 757424009123 motif 1; other site 757424009124 active site 757424009125 motif 2; other site 757424009126 motif 3; other site 757424009127 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 757424009128 Esterase/lipase [General function prediction only]; Region: COG1647 757424009129 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 757424009130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424009133 dimerization interface [polypeptide binding]; other site 757424009134 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 757424009135 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 757424009136 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 757424009137 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 757424009138 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 757424009139 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 757424009140 NAD binding site [chemical binding]; other site 757424009141 catalytic Zn binding site [ion binding]; other site 757424009142 substrate binding site [chemical binding]; other site 757424009143 structural Zn binding site [ion binding]; other site 757424009144 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 757424009145 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 757424009146 CoA-transferase family III; Region: CoA_transf_3; pfam02515 757424009147 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 757424009148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424009149 active site 757424009150 Uncharacterized conserved protein [Function unknown]; Region: COG3777 757424009151 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 757424009152 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 757424009153 active site 2 [active] 757424009154 active site 1 [active] 757424009155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009157 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 757424009158 putative dimerization interface [polypeptide binding]; other site 757424009159 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 757424009160 short chain dehydrogenase; Provisional; Region: PRK08339 757424009161 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 757424009162 putative NAD(P) binding site [chemical binding]; other site 757424009163 putative active site [active] 757424009164 Restriction endonuclease; Region: Mrr_cat; pfam04471 757424009165 partial transposase 757424009166 BRO family, N-terminal domain; Region: Bro-N; pfam02498 757424009167 protease TldD; Provisional; Region: tldD; PRK10735 757424009168 peptidase PmbA; Provisional; Region: PRK11040 757424009169 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 757424009170 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 757424009171 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 757424009172 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 757424009173 TolR protein; Region: tolR; TIGR02801 757424009174 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 757424009175 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 757424009176 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424009177 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424009178 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424009179 N-terminal plug; other site 757424009180 ligand-binding site [chemical binding]; other site 757424009181 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424009182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424009183 putative DNA binding site [nucleotide binding]; other site 757424009184 putative Zn2+ binding site [ion binding]; other site 757424009185 AsnC family; Region: AsnC_trans_reg; pfam01037 757424009186 RNA polymerase sigma factor; Reviewed; Region: PRK12527 757424009187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424009188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424009189 DNA binding residues [nucleotide binding] 757424009190 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 757424009191 FecR protein; Region: FecR; pfam04773 757424009192 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424009193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424009194 DNA-binding site [nucleotide binding]; DNA binding site 757424009195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424009196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424009197 homodimer interface [polypeptide binding]; other site 757424009198 catalytic residue [active] 757424009199 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 757424009200 catalytic residues [active] 757424009201 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 757424009202 dimer interface [polypeptide binding]; other site 757424009203 partial transposase 757424009204 cysteine desulfurase; Provisional; Region: PRK14012 757424009205 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 757424009206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424009207 catalytic residue [active] 757424009208 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 757424009209 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 757424009210 trimerization site [polypeptide binding]; other site 757424009211 active site 757424009212 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 757424009213 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 757424009214 chaperone protein HscA; Provisional; Region: hscA; PRK05183 757424009215 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 757424009216 nucleotide binding site [chemical binding]; other site 757424009217 putative NEF/HSP70 interaction site [polypeptide binding]; other site 757424009218 SBD interface [polypeptide binding]; other site 757424009219 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424009220 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 757424009221 catalytic loop [active] 757424009222 iron binding site [ion binding]; other site 757424009223 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 757424009224 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 757424009225 active site 757424009226 catalytic residues [active] 757424009227 metal binding site [ion binding]; metal-binding site 757424009228 Nitrogen fixation protein NifW; Region: NifW; pfam03206 757424009229 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 757424009230 Ligand binding site [chemical binding]; other site 757424009231 Electron transfer flavoprotein domain; Region: ETF; pfam01012 757424009232 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 757424009233 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 757424009234 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 757424009235 oxidoreductase; Provisional; Region: PRK10015 757424009236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424009237 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 757424009238 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 757424009239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424009240 Walker A/P-loop; other site 757424009241 ATP binding site [chemical binding]; other site 757424009242 Q-loop/lid; other site 757424009243 ABC transporter signature motif; other site 757424009244 Walker B; other site 757424009245 D-loop; other site 757424009246 H-loop/switch region; other site 757424009247 TOBE domain; Region: TOBE; pfam03459 757424009248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424009249 ABC-ATPase subunit interface; other site 757424009250 putative PBP binding loops; other site 757424009251 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 757424009252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424009253 NifQ; Region: NifQ; pfam04891 757424009254 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 757424009255 Rop-like; Region: Rop-like; pfam05082 757424009256 probable nitrogen fixation protein; Region: TIGR02935 757424009257 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 757424009258 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 757424009259 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 757424009260 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 757424009261 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 757424009262 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 757424009263 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 757424009264 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 757424009265 MoFe protein beta/alpha subunit interactions; other site 757424009266 Beta subunit P cluster binding residues; other site 757424009267 MoFe protein beta subunit/Fe protein contacts; other site 757424009268 MoFe protein dimer/ dimer interactions; other site 757424009269 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 757424009270 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 757424009271 MoFe protein alpha/beta subunit interactions; other site 757424009272 Alpha subunit P cluster binding residues; other site 757424009273 FeMoco binding residues [chemical binding]; other site 757424009274 MoFe protein alpha subunit/Fe protein contacts; other site 757424009275 MoFe protein dimer/ dimer interactions; other site 757424009276 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 757424009277 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 757424009278 Nucleotide-binding sites [chemical binding]; other site 757424009279 Walker A motif; other site 757424009280 Switch I region of nucleotide binding site; other site 757424009281 Fe4S4 binding sites [ion binding]; other site 757424009282 Switch II region of nucleotide binding site; other site 757424009283 Response regulator receiver domain; Region: Response_reg; pfam00072 757424009284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009285 active site 757424009286 phosphorylation site [posttranslational modification] 757424009287 intermolecular recognition site; other site 757424009288 dimerization interface [polypeptide binding]; other site 757424009289 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 757424009290 apolar tunnel; other site 757424009291 heme binding site [chemical binding]; other site 757424009292 dimerization interface [polypeptide binding]; other site 757424009293 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 757424009294 SIR2-like domain; Region: SIR2_2; pfam13289 757424009295 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 757424009296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424009297 catalytic loop [active] 757424009298 iron binding site [ion binding]; other site 757424009299 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 757424009300 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 757424009301 inhibitor-cofactor binding pocket; inhibition site 757424009302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424009303 catalytic residue [active] 757424009304 NifT/FixU protein; Region: NifT; pfam06988 757424009305 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 757424009306 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 757424009307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424009308 catalytic residue [active] 757424009309 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 757424009310 NifZ domain; Region: NifZ; pfam04319 757424009311 NifZ domain; Region: NifZ; pfam04319 757424009312 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 757424009313 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 757424009314 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 757424009315 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 757424009316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424009317 FeS/SAM binding site; other site 757424009318 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 757424009319 Nif-specific regulatory protein; Region: nifA; TIGR01817 757424009320 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 757424009321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424009322 Walker A motif; other site 757424009323 ATP binding site [chemical binding]; other site 757424009324 Walker B motif; other site 757424009325 arginine finger; other site 757424009326 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424009327 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 757424009328 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 757424009329 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 757424009330 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 757424009331 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 757424009332 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 757424009333 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 757424009334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 757424009335 dimer interface [polypeptide binding]; other site 757424009336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424009337 metal binding site [ion binding]; metal-binding site 757424009338 H-NS histone family; Region: Histone_HNS; pfam00816 757424009339 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 757424009340 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 757424009341 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 757424009342 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 757424009343 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 757424009344 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 757424009345 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 757424009346 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 757424009347 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424009348 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424009349 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 757424009350 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 757424009351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424009352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424009353 Walker A/P-loop; other site 757424009354 ATP binding site [chemical binding]; other site 757424009355 Q-loop/lid; other site 757424009356 ABC transporter signature motif; other site 757424009357 Walker B; other site 757424009358 D-loop; other site 757424009359 H-loop/switch region; other site 757424009360 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 757424009361 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 757424009362 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 757424009363 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424009364 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424009365 trimer interface [polypeptide binding]; other site 757424009366 eyelet of channel; other site 757424009367 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 757424009368 Permease; Region: Permease; pfam02405 757424009369 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 757424009370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424009371 Walker A/P-loop; other site 757424009372 ATP binding site [chemical binding]; other site 757424009373 Q-loop/lid; other site 757424009374 ABC transporter signature motif; other site 757424009375 Walker B; other site 757424009376 D-loop; other site 757424009377 H-loop/switch region; other site 757424009378 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 757424009379 mce related protein; Region: MCE; pfam02470 757424009380 Protein of unknown function (DUF330); Region: DUF330; cl01135 757424009381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009383 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424009384 putative effector binding pocket; other site 757424009385 dimerization interface [polypeptide binding]; other site 757424009386 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 757424009387 LrgA family; Region: LrgA; pfam03788 757424009388 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 757424009389 substrate binding site [chemical binding]; other site 757424009390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424009391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424009392 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 757424009393 MgtC family; Region: MgtC; pfam02308 757424009394 hypothetical protein; Provisional; Region: PRK02237 757424009395 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 757424009396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424009397 nitrite reductase subunit NirD; Provisional; Region: PRK14989 757424009398 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424009399 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 757424009400 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 757424009401 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 757424009402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 757424009403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424009404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424009405 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 757424009406 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 757424009407 [4Fe-4S] binding site [ion binding]; other site 757424009408 molybdopterin cofactor binding site; other site 757424009409 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 757424009410 molybdopterin cofactor binding site; other site 757424009411 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 757424009412 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 757424009413 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 757424009414 putative active site [active] 757424009415 putative NTP binding site [chemical binding]; other site 757424009416 putative nucleic acid binding site [nucleotide binding]; other site 757424009417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424009418 non-specific DNA binding site [nucleotide binding]; other site 757424009419 salt bridge; other site 757424009420 sequence-specific DNA binding site [nucleotide binding]; other site 757424009421 AntA/AntB antirepressor; Region: AntA; pfam08346 757424009422 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 757424009423 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 757424009424 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 757424009425 Transposase; Region: HTH_Tnp_1; pfam01527 757424009426 HTH-like domain; Region: HTH_21; pfam13276 757424009427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 757424009428 Integrase core domain; Region: rve; pfam00665 757424009429 site-specific phage recombinase/integrase truncated protein 757424009430 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 757424009431 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424009432 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424009433 HAMP domain; Region: HAMP; pfam00672 757424009434 dimerization interface [polypeptide binding]; other site 757424009435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424009436 dimer interface [polypeptide binding]; other site 757424009437 putative CheW interface [polypeptide binding]; other site 757424009438 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424009439 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424009440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424009441 dimerization interface [polypeptide binding]; other site 757424009442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424009443 dimer interface [polypeptide binding]; other site 757424009444 putative CheW interface [polypeptide binding]; other site 757424009445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424009446 Coenzyme A binding pocket [chemical binding]; other site 757424009447 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 757424009448 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 757424009449 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 757424009450 G1 box; other site 757424009451 putative GEF interaction site [polypeptide binding]; other site 757424009452 GTP/Mg2+ binding site [chemical binding]; other site 757424009453 Switch I region; other site 757424009454 G2 box; other site 757424009455 G3 box; other site 757424009456 Switch II region; other site 757424009457 G4 box; other site 757424009458 G5 box; other site 757424009459 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 757424009460 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 757424009461 dimer interface [polypeptide binding]; other site 757424009462 substrate binding site [chemical binding]; other site 757424009463 metal binding sites [ion binding]; metal-binding site 757424009464 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 757424009465 HemY protein N-terminus; Region: HemY_N; pfam07219 757424009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009467 TPR motif; other site 757424009468 binding surface 757424009469 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 757424009470 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 757424009471 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 757424009472 active site 757424009473 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 757424009474 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 757424009475 domain interfaces; other site 757424009476 active site 757424009477 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 757424009478 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 757424009479 HDOD domain; Region: HDOD; pfam08668 757424009480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 757424009481 argininosuccinate lyase; Provisional; Region: PRK00855 757424009482 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 757424009483 active sites [active] 757424009484 tetramer interface [polypeptide binding]; other site 757424009485 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424009486 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424009487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424009488 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424009489 TM-ABC transporter signature motif; other site 757424009490 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424009491 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424009492 TM-ABC transporter signature motif; other site 757424009493 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424009494 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424009495 Walker A/P-loop; other site 757424009496 ATP binding site [chemical binding]; other site 757424009497 Q-loop/lid; other site 757424009498 ABC transporter signature motif; other site 757424009499 Walker B; other site 757424009500 D-loop; other site 757424009501 H-loop/switch region; other site 757424009502 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424009503 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424009504 Walker A/P-loop; other site 757424009505 ATP binding site [chemical binding]; other site 757424009506 Q-loop/lid; other site 757424009507 ABC transporter signature motif; other site 757424009508 Walker B; other site 757424009509 D-loop; other site 757424009510 H-loop/switch region; other site 757424009511 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 757424009512 Transglycosylase; Region: Transgly; pfam00912 757424009513 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 757424009514 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 757424009515 Bacterial Ig-like domain; Region: Big_5; pfam13205 757424009516 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 757424009517 MG2 domain; Region: A2M_N; pfam01835 757424009518 Alpha-2-macroglobulin family; Region: A2M; pfam00207 757424009519 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 757424009520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424009523 dimerization interface [polypeptide binding]; other site 757424009524 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424009525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424009526 putative substrate translocation pore; other site 757424009527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424009528 active site 757424009529 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 757424009530 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 757424009531 GDP-binding site [chemical binding]; other site 757424009532 ACT binding site; other site 757424009533 IMP binding site; other site 757424009534 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 757424009535 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 757424009536 dimer interface [polypeptide binding]; other site 757424009537 motif 1; other site 757424009538 active site 757424009539 motif 2; other site 757424009540 motif 3; other site 757424009541 HflC protein; Region: hflC; TIGR01932 757424009542 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 757424009543 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 757424009544 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 757424009545 HflK protein; Region: hflK; TIGR01933 757424009546 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 757424009547 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 757424009548 HflX GTPase family; Region: HflX; cd01878 757424009549 G1 box; other site 757424009550 GTP/Mg2+ binding site [chemical binding]; other site 757424009551 Switch I region; other site 757424009552 G2 box; other site 757424009553 G3 box; other site 757424009554 Switch II region; other site 757424009555 G4 box; other site 757424009556 G5 box; other site 757424009557 bacterial Hfq-like; Region: Hfq; cd01716 757424009558 hexamer interface [polypeptide binding]; other site 757424009559 Sm1 motif; other site 757424009560 RNA binding site [nucleotide binding]; other site 757424009561 Sm2 motif; other site 757424009562 GTP-binding protein Der; Reviewed; Region: PRK00093 757424009563 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 757424009564 G1 box; other site 757424009565 GTP/Mg2+ binding site [chemical binding]; other site 757424009566 Switch I region; other site 757424009567 G2 box; other site 757424009568 Switch II region; other site 757424009569 G3 box; other site 757424009570 G4 box; other site 757424009571 G5 box; other site 757424009572 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 757424009573 G1 box; other site 757424009574 GTP/Mg2+ binding site [chemical binding]; other site 757424009575 Switch I region; other site 757424009576 G2 box; other site 757424009577 G3 box; other site 757424009578 Switch II region; other site 757424009579 G4 box; other site 757424009580 G5 box; other site 757424009581 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 757424009582 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 757424009583 Trp docking motif [polypeptide binding]; other site 757424009584 active site 757424009585 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 757424009586 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 757424009587 dimer interface [polypeptide binding]; other site 757424009588 motif 1; other site 757424009589 active site 757424009590 motif 2; other site 757424009591 motif 3; other site 757424009592 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 757424009593 anticodon binding site; other site 757424009594 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 757424009595 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 757424009596 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 757424009597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424009598 non-specific DNA binding site [nucleotide binding]; other site 757424009599 salt bridge; other site 757424009600 sequence-specific DNA binding site [nucleotide binding]; other site 757424009601 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 757424009602 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 757424009603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424009604 FeS/SAM binding site; other site 757424009605 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 757424009606 active site 757424009607 multimer interface [polypeptide binding]; other site 757424009608 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 757424009609 YccA-like proteins; Region: YccA_like; cd10433 757424009610 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 757424009611 TRAM domain; Region: TRAM; cl01282 757424009612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424009613 S-adenosylmethionine binding site [chemical binding]; other site 757424009614 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 757424009615 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 757424009616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424009617 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 757424009618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424009619 DNA binding residues [nucleotide binding] 757424009620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 757424009621 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424009622 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 757424009623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424009624 S-adenosylmethionine binding site [chemical binding]; other site 757424009625 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 757424009626 Flagellar protein YcgR; Region: YcgR_2; pfam12945 757424009627 PilZ domain; Region: PilZ; pfam07238 757424009628 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 757424009629 DEAD/DEAH box helicase; Region: DEAD; pfam00270 757424009630 ATP binding site [chemical binding]; other site 757424009631 ATP binding site [chemical binding]; other site 757424009632 DEAD_2; Region: DEAD_2; pfam06733 757424009633 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 757424009634 Predicted ATPase [General function prediction only]; Region: COG1485 757424009635 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 757424009636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424009637 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 757424009638 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 757424009639 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 757424009640 E3 interaction surface; other site 757424009641 lipoyl attachment site [posttranslational modification]; other site 757424009642 e3 binding domain; Region: E3_binding; pfam02817 757424009643 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 757424009644 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 757424009645 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 757424009646 TPP-binding site [chemical binding]; other site 757424009647 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 757424009648 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 757424009649 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 757424009650 dimer interface [polypeptide binding]; other site 757424009651 active site 757424009652 citrylCoA binding site [chemical binding]; other site 757424009653 NADH binding [chemical binding]; other site 757424009654 cationic pore residues; other site 757424009655 oxalacetate/citrate binding site [chemical binding]; other site 757424009656 coenzyme A binding site [chemical binding]; other site 757424009657 catalytic triad [active] 757424009658 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 757424009659 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 757424009660 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 757424009661 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 757424009662 L-aspartate oxidase; Provisional; Region: PRK06175 757424009663 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 757424009664 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 757424009665 Iron-sulfur protein interface; other site 757424009666 proximal quinone binding site [chemical binding]; other site 757424009667 SdhD (CybS) interface [polypeptide binding]; other site 757424009668 proximal heme binding site [chemical binding]; other site 757424009669 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 757424009670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424009671 DNA-binding site [nucleotide binding]; DNA binding site 757424009672 UTRA domain; Region: UTRA; pfam07702 757424009673 malate dehydrogenase; Provisional; Region: PRK05442 757424009674 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 757424009675 NAD(P) binding site [chemical binding]; other site 757424009676 dimer interface [polypeptide binding]; other site 757424009677 malate binding site [chemical binding]; other site 757424009678 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 757424009679 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 757424009680 aconitate hydratase; Validated; Region: PRK09277 757424009681 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 757424009682 substrate binding site [chemical binding]; other site 757424009683 ligand binding site [chemical binding]; other site 757424009684 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 757424009685 substrate binding site [chemical binding]; other site 757424009686 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 757424009687 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 757424009688 putative CheA interaction surface; other site 757424009689 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424009690 putative binding surface; other site 757424009691 active site 757424009692 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 757424009693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424009694 ATP binding site [chemical binding]; other site 757424009695 Mg2+ binding site [ion binding]; other site 757424009696 G-X-G motif; other site 757424009697 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 757424009698 Response regulator receiver domain; Region: Response_reg; pfam00072 757424009699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009700 active site 757424009701 phosphorylation site [posttranslational modification] 757424009702 intermolecular recognition site; other site 757424009703 dimerization interface [polypeptide binding]; other site 757424009704 flagellar motor protein MotB; Validated; Region: motB; PRK09041 757424009705 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 757424009706 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424009707 ligand binding site [chemical binding]; other site 757424009708 flagellar motor protein MotA; Validated; Region: PRK09110 757424009709 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 757424009710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424009711 S-adenosylmethionine binding site [chemical binding]; other site 757424009712 transcriptional activator FlhC; Provisional; Region: PRK12722 757424009713 transcriptional activator FlhD; Provisional; Region: PRK02909 757424009714 cystathionine beta-lyase; Provisional; Region: PRK07050 757424009715 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 757424009716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424009717 catalytic residue [active] 757424009718 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 757424009719 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 757424009720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424009721 FeS/SAM binding site; other site 757424009722 TRAM domain; Region: TRAM; cl01282 757424009723 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 757424009724 AAA domain; Region: AAA_28; pfam13521 757424009725 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 757424009726 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424009727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009729 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424009730 putative effector binding pocket; other site 757424009731 dimerization interface [polypeptide binding]; other site 757424009732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 757424009733 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 757424009734 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 757424009735 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 757424009736 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 757424009737 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 757424009738 NAD(P) binding site [chemical binding]; other site 757424009739 homotetramer interface [polypeptide binding]; other site 757424009740 homodimer interface [polypeptide binding]; other site 757424009741 active site 757424009742 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 757424009743 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 757424009744 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 757424009745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 757424009748 putative dimerization interface [polypeptide binding]; other site 757424009749 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 757424009750 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 757424009751 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 757424009752 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424009753 RNA binding surface [nucleotide binding]; other site 757424009754 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 757424009755 active site 757424009756 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 757424009757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 757424009758 binding surface 757424009759 TPR motif; other site 757424009760 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 757424009761 Amidase; Region: Amidase; pfam01425 757424009762 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 757424009763 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424009764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424009765 hypothetical protein; Validated; Region: PRK02101 757424009766 PIN domain; Region: PIN_3; pfam13470 757424009767 methionine aminotransferase; Validated; Region: PRK09082 757424009768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424009769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424009770 homodimer interface [polypeptide binding]; other site 757424009771 catalytic residue [active] 757424009772 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 757424009773 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 757424009774 C-terminal domain interface [polypeptide binding]; other site 757424009775 GSH binding site (G-site) [chemical binding]; other site 757424009776 dimer interface [polypeptide binding]; other site 757424009777 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 757424009778 N-terminal domain interface [polypeptide binding]; other site 757424009779 putative dimer interface [polypeptide binding]; other site 757424009780 active site 757424009781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424009782 PAS fold; Region: PAS_3; pfam08447 757424009783 putative active site [active] 757424009784 heme pocket [chemical binding]; other site 757424009785 PAS domain; Region: PAS_9; pfam13426 757424009786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424009787 putative active site [active] 757424009788 heme pocket [chemical binding]; other site 757424009789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424009790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424009791 metal binding site [ion binding]; metal-binding site 757424009792 active site 757424009793 I-site; other site 757424009794 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 757424009795 putative active site [active] 757424009796 putative catalytic site [active] 757424009797 Response regulator receiver domain; Region: Response_reg; pfam00072 757424009798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009799 active site 757424009800 phosphorylation site [posttranslational modification] 757424009801 intermolecular recognition site; other site 757424009802 dimerization interface [polypeptide binding]; other site 757424009803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424009804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424009805 metal binding site [ion binding]; metal-binding site 757424009806 active site 757424009807 I-site; other site 757424009808 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 757424009809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009810 active site 757424009811 phosphorylation site [posttranslational modification] 757424009812 intermolecular recognition site; other site 757424009813 CheB methylesterase; Region: CheB_methylest; pfam01339 757424009814 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424009815 putative binding surface; other site 757424009816 active site 757424009817 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 757424009818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424009819 ATP binding site [chemical binding]; other site 757424009820 Mg2+ binding site [ion binding]; other site 757424009821 G-X-G motif; other site 757424009822 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424009823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424009824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009825 active site 757424009826 phosphorylation site [posttranslational modification] 757424009827 intermolecular recognition site; other site 757424009828 dimerization interface [polypeptide binding]; other site 757424009829 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424009830 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 757424009831 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 757424009832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009833 TPR repeat; Region: TPR_11; pfam13414 757424009834 binding surface 757424009835 TPR motif; other site 757424009836 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424009837 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424009838 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424009839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424009840 dimerization interface [polypeptide binding]; other site 757424009841 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424009842 dimer interface [polypeptide binding]; other site 757424009843 putative CheW interface [polypeptide binding]; other site 757424009844 Predicted membrane protein [Function unknown]; Region: COG3671 757424009845 phosphoserine phosphatase SerB; Region: serB; TIGR00338 757424009846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424009847 motif II; other site 757424009848 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 757424009849 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 757424009850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424009851 ATP binding site [chemical binding]; other site 757424009852 putative Mg++ binding site [ion binding]; other site 757424009853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424009854 nucleotide binding region [chemical binding]; other site 757424009855 ATP-binding site [chemical binding]; other site 757424009856 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 757424009857 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 757424009858 substrate binding site; other site 757424009859 dimer interface; other site 757424009860 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 757424009861 homotrimer interaction site [polypeptide binding]; other site 757424009862 zinc binding site [ion binding]; other site 757424009863 CDP-binding sites; other site 757424009864 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 757424009865 DNA-binding site [nucleotide binding]; DNA binding site 757424009866 RNA-binding motif; other site 757424009867 malate synthase A; Region: malate_syn_A; TIGR01344 757424009868 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 757424009869 active site 757424009870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424009871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424009872 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424009873 putative effector binding pocket; other site 757424009874 dimerization interface [polypeptide binding]; other site 757424009875 Beta-lactamase; Region: Beta-lactamase; pfam00144 757424009876 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 757424009877 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424009878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424009879 dimerization interface [polypeptide binding]; other site 757424009880 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424009881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424009882 dimer interface [polypeptide binding]; other site 757424009883 putative CheW interface [polypeptide binding]; other site 757424009884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424009885 DNA-binding site [nucleotide binding]; DNA binding site 757424009886 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424009887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424009888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424009889 homodimer interface [polypeptide binding]; other site 757424009890 catalytic residue [active] 757424009891 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 757424009892 homodimer interface [polypeptide binding]; other site 757424009893 catalytic residues [active] 757424009894 NAD binding site [chemical binding]; other site 757424009895 substrate binding pocket [chemical binding]; other site 757424009896 flexible flap; other site 757424009897 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424009898 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 757424009899 putative ligand binding site [chemical binding]; other site 757424009900 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424009901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424009902 putative substrate translocation pore; other site 757424009903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424009904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424009905 non-specific DNA binding site [nucleotide binding]; other site 757424009906 salt bridge; other site 757424009907 sequence-specific DNA binding site [nucleotide binding]; other site 757424009908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 757424009909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424009910 non-specific DNA binding site [nucleotide binding]; other site 757424009911 salt bridge; other site 757424009912 sequence-specific DNA binding site [nucleotide binding]; other site 757424009913 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 757424009914 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 757424009915 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 757424009916 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 757424009917 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424009918 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424009919 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 757424009920 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424009921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424009922 Walker A/P-loop; other site 757424009923 ATP binding site [chemical binding]; other site 757424009924 Q-loop/lid; other site 757424009925 ABC transporter signature motif; other site 757424009926 Walker B; other site 757424009927 D-loop; other site 757424009928 H-loop/switch region; other site 757424009929 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 757424009930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009931 binding surface 757424009932 TPR motif; other site 757424009933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424009934 binding surface 757424009935 TPR motif; other site 757424009936 TPR repeat; Region: TPR_11; pfam13414 757424009937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424009938 methionine sulfoxide reductase A; Provisional; Region: PRK13014 757424009939 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 757424009940 TMAO/DMSO reductase; Reviewed; Region: PRK05363 757424009941 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 757424009942 Moco binding site; other site 757424009943 metal coordination site [ion binding]; other site 757424009944 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 757424009945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424009946 active site 757424009947 phosphorylation site [posttranslational modification] 757424009948 intermolecular recognition site; other site 757424009949 dimerization interface [polypeptide binding]; other site 757424009950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424009951 DNA binding site [nucleotide binding] 757424009952 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 757424009953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424009954 dimerization interface [polypeptide binding]; other site 757424009955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424009956 dimer interface [polypeptide binding]; other site 757424009957 phosphorylation site [posttranslational modification] 757424009958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424009959 ATP binding site [chemical binding]; other site 757424009960 Mg2+ binding site [ion binding]; other site 757424009961 G-X-G motif; other site 757424009962 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 757424009963 Predicted transcriptional regulators [Transcription]; Region: COG1510 757424009964 MarR family; Region: MarR_2; pfam12802 757424009965 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 757424009966 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 757424009967 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 757424009968 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 757424009969 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 757424009970 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 757424009971 Transcriptional regulators [Transcription]; Region: MarR; COG1846 757424009972 MarR family; Region: MarR; pfam01047 757424009973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 757424009974 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 757424009975 elongation factor P; Validated; Region: PRK00529 757424009976 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 757424009977 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 757424009978 RNA binding site [nucleotide binding]; other site 757424009979 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 757424009980 RNA binding site [nucleotide binding]; other site 757424009981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424009982 DNA-binding site [nucleotide binding]; DNA binding site 757424009983 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424009984 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424009985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424009986 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 757424009987 putative NAD(P) binding site [chemical binding]; other site 757424009988 active site 757424009989 putative substrate binding site [chemical binding]; other site 757424009990 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 757424009991 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 757424009992 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 757424009993 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 757424009994 tetrameric interface [polypeptide binding]; other site 757424009995 NAD binding site [chemical binding]; other site 757424009996 catalytic residues [active] 757424009997 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424009998 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 757424009999 putative ligand binding site [chemical binding]; other site 757424010000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424010001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424010003 dimerization interface [polypeptide binding]; other site 757424010004 intracellular protease, PfpI family; Region: PfpI; TIGR01382 757424010005 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 757424010006 conserved cys residue [active] 757424010007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424010008 PAS domain; Region: PAS_9; pfam13426 757424010009 putative active site [active] 757424010010 heme pocket [chemical binding]; other site 757424010011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424010012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010013 dimer interface [polypeptide binding]; other site 757424010014 putative CheW interface [polypeptide binding]; other site 757424010015 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 757424010016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424010017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424010018 DNA binding residues [nucleotide binding] 757424010019 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 757424010020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424010021 enoyl-CoA hydratase; Provisional; Region: PRK05995 757424010022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424010023 substrate binding site [chemical binding]; other site 757424010024 oxyanion hole (OAH) forming residues; other site 757424010025 trimer interface [polypeptide binding]; other site 757424010026 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 757424010027 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 757424010028 active site 757424010029 HIGH motif; other site 757424010030 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 757424010031 active site 757424010032 KMSKS motif; other site 757424010033 Domain of unknown function DUF59; Region: DUF59; pfam01883 757424010034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 757424010035 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 757424010036 Walker A motif; other site 757424010037 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 757424010038 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 757424010039 active site 757424010040 HIGH motif; other site 757424010041 KMSKS motif; other site 757424010042 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 757424010043 anticodon binding site; other site 757424010044 tRNA binding surface [nucleotide binding]; other site 757424010045 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 757424010046 dimer interface [polypeptide binding]; other site 757424010047 putative tRNA-binding site [nucleotide binding]; other site 757424010048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424010049 Coenzyme A binding pocket [chemical binding]; other site 757424010050 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 757424010051 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 757424010052 non-specific DNA interactions [nucleotide binding]; other site 757424010053 DNA binding site [nucleotide binding] 757424010054 sequence specific DNA binding site [nucleotide binding]; other site 757424010055 putative cAMP binding site [chemical binding]; other site 757424010056 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 757424010057 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 757424010058 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 757424010059 Walker A/P-loop; other site 757424010060 ATP binding site [chemical binding]; other site 757424010061 Q-loop/lid; other site 757424010062 ABC transporter signature motif; other site 757424010063 Walker B; other site 757424010064 D-loop; other site 757424010065 H-loop/switch region; other site 757424010066 TOBE domain; Region: TOBE_2; pfam08402 757424010067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424010068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424010069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010070 dimer interface [polypeptide binding]; other site 757424010071 conserved gate region; other site 757424010072 putative PBP binding loops; other site 757424010073 ABC-ATPase subunit interface; other site 757424010074 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424010075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010076 dimer interface [polypeptide binding]; other site 757424010077 putative PBP binding loops; other site 757424010078 ABC-ATPase subunit interface; other site 757424010079 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 757424010080 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 757424010081 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 757424010082 pantoate--beta-alanine ligase; Region: panC; TIGR00018 757424010083 Pantoate-beta-alanine ligase; Region: PanC; cd00560 757424010084 active site 757424010085 ATP-binding site [chemical binding]; other site 757424010086 pantoate-binding site; other site 757424010087 HXXH motif; other site 757424010088 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 757424010089 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 757424010090 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424010091 putative binding surface; other site 757424010092 active site 757424010093 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 757424010094 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 757424010095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424010096 ATP binding site [chemical binding]; other site 757424010097 Mg2+ binding site [ion binding]; other site 757424010098 G-X-G motif; other site 757424010099 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424010100 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 757424010101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010102 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 757424010103 substrate binding site [chemical binding]; other site 757424010104 dimerization interface [polypeptide binding]; other site 757424010105 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 757424010106 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 757424010107 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 757424010108 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 757424010109 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 757424010110 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 757424010111 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 757424010112 Active Sites [active] 757424010113 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 757424010114 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 757424010115 Active Sites [active] 757424010116 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 757424010117 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 757424010118 CysD dimerization site [polypeptide binding]; other site 757424010119 G1 box; other site 757424010120 putative GEF interaction site [polypeptide binding]; other site 757424010121 GTP/Mg2+ binding site [chemical binding]; other site 757424010122 Switch I region; other site 757424010123 G2 box; other site 757424010124 G3 box; other site 757424010125 Switch II region; other site 757424010126 G4 box; other site 757424010127 G5 box; other site 757424010128 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 757424010129 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 757424010130 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 757424010131 active site 757424010132 SAM binding site [chemical binding]; other site 757424010133 homodimer interface [polypeptide binding]; other site 757424010134 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 757424010135 dimer interface [polypeptide binding]; other site 757424010136 putative tRNA-binding site [nucleotide binding]; other site 757424010137 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 757424010138 putative active site [active] 757424010139 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 757424010140 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 757424010141 Predicted permeases [General function prediction only]; Region: COG0795 757424010142 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 757424010143 multifunctional aminopeptidase A; Provisional; Region: PRK00913 757424010144 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 757424010145 interface (dimer of trimers) [polypeptide binding]; other site 757424010146 Substrate-binding/catalytic site; other site 757424010147 Zn-binding sites [ion binding]; other site 757424010148 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 757424010149 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 757424010150 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 757424010151 FMN binding site [chemical binding]; other site 757424010152 active site 757424010153 substrate binding site [chemical binding]; other site 757424010154 catalytic residue [active] 757424010155 MltA-interacting protein MipA; Region: MipA; cl01504 757424010156 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 757424010157 putative catalytic site [active] 757424010158 putative phosphate binding site [ion binding]; other site 757424010159 active site 757424010160 metal binding site A [ion binding]; metal-binding site 757424010161 DNA binding site [nucleotide binding] 757424010162 putative AP binding site [nucleotide binding]; other site 757424010163 putative metal binding site B [ion binding]; other site 757424010164 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 757424010165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424010166 Coenzyme A binding pocket [chemical binding]; other site 757424010167 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 757424010168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424010169 acyl-activating enzyme (AAE) consensus motif; other site 757424010170 AMP binding site [chemical binding]; other site 757424010171 active site 757424010172 CoA binding site [chemical binding]; other site 757424010173 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 757424010174 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 757424010175 dimer interface [polypeptide binding]; other site 757424010176 active site 757424010177 citrylCoA binding site [chemical binding]; other site 757424010178 oxalacetate/citrate binding site [chemical binding]; other site 757424010179 coenzyme A binding site [chemical binding]; other site 757424010180 catalytic triad [active] 757424010181 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 757424010182 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 757424010183 tetramer interface [polypeptide binding]; other site 757424010184 active site 757424010185 Mg2+/Mn2+ binding site [ion binding]; other site 757424010186 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 757424010187 Propionate catabolism activator; Region: PrpR_N; pfam06506 757424010188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424010189 Walker A motif; other site 757424010190 ATP binding site [chemical binding]; other site 757424010191 Walker B motif; other site 757424010192 arginine finger; other site 757424010193 citrate-proton symporter; Provisional; Region: PRK15075 757424010194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010195 putative substrate translocation pore; other site 757424010196 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424010197 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010198 dimer interface [polypeptide binding]; other site 757424010199 putative CheW interface [polypeptide binding]; other site 757424010200 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 757424010201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010202 active site 757424010203 phosphorylation site [posttranslational modification] 757424010204 intermolecular recognition site; other site 757424010205 dimerization interface [polypeptide binding]; other site 757424010206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424010207 Walker A motif; other site 757424010208 ATP binding site [chemical binding]; other site 757424010209 Walker B motif; other site 757424010210 arginine finger; other site 757424010211 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424010212 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 757424010213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424010214 putative active site [active] 757424010215 heme pocket [chemical binding]; other site 757424010216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424010217 dimer interface [polypeptide binding]; other site 757424010218 phosphorylation site [posttranslational modification] 757424010219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424010220 ATP binding site [chemical binding]; other site 757424010221 Mg2+ binding site [ion binding]; other site 757424010222 G-X-G motif; other site 757424010223 glutamine synthetase; Provisional; Region: glnA; PRK09469 757424010224 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 757424010225 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 757424010226 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 757424010227 active site residue [active] 757424010228 Response regulator receiver domain; Region: Response_reg; pfam00072 757424010229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010230 active site 757424010231 phosphorylation site [posttranslational modification] 757424010232 intermolecular recognition site; other site 757424010233 dimerization interface [polypeptide binding]; other site 757424010234 Hpt domain; Region: Hpt; pfam01627 757424010235 putative binding surface; other site 757424010236 active site 757424010237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424010238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010239 active site 757424010240 phosphorylation site [posttranslational modification] 757424010241 intermolecular recognition site; other site 757424010242 dimerization interface [polypeptide binding]; other site 757424010243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424010244 DNA binding residues [nucleotide binding] 757424010245 dimerization interface [polypeptide binding]; other site 757424010246 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 757424010247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 757424010248 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 757424010249 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 757424010250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424010251 catalytic loop [active] 757424010252 iron binding site [ion binding]; other site 757424010253 chaperone protein HscA; Provisional; Region: hscA; PRK05183 757424010254 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 757424010255 nucleotide binding site [chemical binding]; other site 757424010256 putative NEF/HSP70 interaction site [polypeptide binding]; other site 757424010257 SBD interface [polypeptide binding]; other site 757424010258 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 757424010259 co-chaperone HscB; Provisional; Region: hscB; PRK03578 757424010260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 757424010261 HSP70 interaction site [polypeptide binding]; other site 757424010262 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 757424010263 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 757424010264 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 757424010265 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 757424010266 trimerization site [polypeptide binding]; other site 757424010267 active site 757424010268 cysteine desulfurase; Provisional; Region: PRK14012 757424010269 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 757424010270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424010271 catalytic residue [active] 757424010272 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 757424010273 Rrf2 family protein; Region: rrf2_super; TIGR00738 757424010274 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424010275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424010276 DNA-binding site [nucleotide binding]; DNA binding site 757424010277 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424010278 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 757424010279 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 757424010280 putative active site [active] 757424010281 catalytic residue [active] 757424010282 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 757424010283 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 757424010284 dimer interface [polypeptide binding]; other site 757424010285 ligand binding site [chemical binding]; other site 757424010286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424010287 dimerization interface [polypeptide binding]; other site 757424010288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010289 dimer interface [polypeptide binding]; other site 757424010290 putative CheW interface [polypeptide binding]; other site 757424010291 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 757424010292 galactarate dehydratase; Region: galactar-dH20; TIGR03248 757424010293 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 757424010294 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 757424010295 D-galactonate transporter; Region: 2A0114; TIGR00893 757424010296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010297 putative substrate translocation pore; other site 757424010298 Predicted permease; Region: DUF318; cl17795 757424010299 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 757424010300 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 757424010301 active site residue [active] 757424010302 selenophosphate synthetase; Provisional; Region: PRK00943 757424010303 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 757424010304 dimerization interface [polypeptide binding]; other site 757424010305 putative ATP binding site [chemical binding]; other site 757424010306 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 757424010307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424010308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424010309 homodimer interface [polypeptide binding]; other site 757424010310 catalytic residue [active] 757424010311 excinuclease ABC subunit B; Provisional; Region: PRK05298 757424010312 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 757424010313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424010314 ATP-binding site [chemical binding]; other site 757424010315 ATP binding site [chemical binding]; other site 757424010316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424010317 nucleotide binding region [chemical binding]; other site 757424010318 ATP-binding site [chemical binding]; other site 757424010319 Ultra-violet resistance protein B; Region: UvrB; pfam12344 757424010320 UvrB/uvrC motif; Region: UVR; pfam02151 757424010321 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 757424010322 ligand binding site [chemical binding]; other site 757424010323 active site 757424010324 Cache domain; Region: Cache_1; pfam02743 757424010325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424010326 dimerization interface [polypeptide binding]; other site 757424010327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010328 dimer interface [polypeptide binding]; other site 757424010329 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424010330 putative CheW interface [polypeptide binding]; other site 757424010331 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424010332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010333 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424010334 dimerization interface [polypeptide binding]; other site 757424010335 substrate binding pocket [chemical binding]; other site 757424010336 Uncharacterized conserved protein [Function unknown]; Region: COG1359 757424010337 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 757424010338 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 757424010339 metal binding site [ion binding]; metal-binding site 757424010340 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 757424010341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 757424010342 ABC-ATPase subunit interface; other site 757424010343 dimer interface [polypeptide binding]; other site 757424010344 putative PBP binding regions; other site 757424010345 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 757424010346 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 757424010347 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 757424010348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 757424010349 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424010350 Walker A/P-loop; other site 757424010351 ATP binding site [chemical binding]; other site 757424010352 Q-loop/lid; other site 757424010353 ABC transporter signature motif; other site 757424010354 Walker B; other site 757424010355 D-loop; other site 757424010356 H-loop/switch region; other site 757424010357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 757424010358 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 757424010359 topology modulation protein; Reviewed; Region: PRK08118 757424010360 AAA domain; Region: AAA_17; pfam13207 757424010361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424010362 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 757424010363 Protein of unknown function (DUF2026); Region: DUF2026; pfam09641 757424010364 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 757424010365 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 757424010366 metal binding site [ion binding]; metal-binding site 757424010367 putative dimer interface [polypeptide binding]; other site 757424010368 hypothetical protein; Provisional; Region: PRK07079 757424010369 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 757424010370 metal binding site [ion binding]; metal-binding site 757424010371 putative dimer interface [polypeptide binding]; other site 757424010372 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 757424010373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424010374 Walker A/P-loop; other site 757424010375 ATP binding site [chemical binding]; other site 757424010376 Q-loop/lid; other site 757424010377 ABC transporter signature motif; other site 757424010378 Walker B; other site 757424010379 D-loop; other site 757424010380 H-loop/switch region; other site 757424010381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424010382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 757424010383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424010384 Walker A/P-loop; other site 757424010385 ATP binding site [chemical binding]; other site 757424010386 Q-loop/lid; other site 757424010387 ABC transporter signature motif; other site 757424010388 Walker B; other site 757424010389 D-loop; other site 757424010390 H-loop/switch region; other site 757424010391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424010392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 757424010393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010394 dimer interface [polypeptide binding]; other site 757424010395 conserved gate region; other site 757424010396 putative PBP binding loops; other site 757424010397 ABC-ATPase subunit interface; other site 757424010398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 757424010399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010400 dimer interface [polypeptide binding]; other site 757424010401 conserved gate region; other site 757424010402 putative PBP binding loops; other site 757424010403 ABC-ATPase subunit interface; other site 757424010404 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 757424010405 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 757424010406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424010407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424010409 dimerization interface [polypeptide binding]; other site 757424010410 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 757424010411 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424010412 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 757424010413 catalytic triad [active] 757424010414 putative active site [active] 757424010415 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 757424010416 Autotransporter beta-domain; Region: Autotransporter; pfam03797 757424010417 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424010418 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 757424010419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010420 putative substrate translocation pore; other site 757424010421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010422 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 757424010423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424010424 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424010425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 757424010426 MarR family; Region: MarR_2; cl17246 757424010427 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 757424010428 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 757424010429 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 757424010430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424010431 putative DNA binding site [nucleotide binding]; other site 757424010432 putative Zn2+ binding site [ion binding]; other site 757424010433 AsnC family; Region: AsnC_trans_reg; pfam01037 757424010434 D-cysteine desulfhydrase; Validated; Region: PRK03910 757424010435 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 757424010436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424010437 catalytic residue [active] 757424010438 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 757424010439 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 757424010440 Fatty acid desaturase; Region: FA_desaturase; pfam00487 757424010441 putative di-iron ligands [ion binding]; other site 757424010442 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 757424010443 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 757424010444 ligand binding site [chemical binding]; other site 757424010445 flexible hinge region; other site 757424010446 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 757424010447 putative switch regulator; other site 757424010448 non-specific DNA interactions [nucleotide binding]; other site 757424010449 DNA binding site [nucleotide binding] 757424010450 sequence specific DNA binding site [nucleotide binding]; other site 757424010451 putative cAMP binding site [chemical binding]; other site 757424010452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 757424010453 FixH; Region: FixH; pfam05751 757424010454 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 757424010455 4Fe-4S binding domain; Region: Fer4_5; pfam12801 757424010456 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 757424010457 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 757424010458 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 757424010459 Cytochrome c; Region: Cytochrom_C; pfam00034 757424010460 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 757424010461 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 757424010462 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 757424010463 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 757424010464 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 757424010465 Low-spin heme binding site [chemical binding]; other site 757424010466 Putative water exit pathway; other site 757424010467 Binuclear center (active site) [active] 757424010468 Putative proton exit pathway; other site 757424010469 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 757424010470 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 757424010471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 757424010472 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 757424010473 metal-binding site [ion binding] 757424010474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424010475 Soluble P-type ATPase [General function prediction only]; Region: COG4087 757424010476 Family description; Region: DsbD_2; pfam13386 757424010477 Family description; Region: DsbD_2; pfam13386 757424010478 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 757424010479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424010480 FeS/SAM binding site; other site 757424010481 HemN C-terminal domain; Region: HemN_C; pfam06969 757424010482 aromatic amino acid exporter; Provisional; Region: PRK11689 757424010483 hypothetical protein; Provisional; Region: PRK11212 757424010484 MFS transport protein AraJ; Provisional; Region: PRK10091 757424010485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010486 putative substrate translocation pore; other site 757424010487 acetylornithine deacetylase; Provisional; Region: PRK07522 757424010488 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 757424010489 metal binding site [ion binding]; metal-binding site 757424010490 putative dimer interface [polypeptide binding]; other site 757424010491 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424010492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 757424010493 active site 757424010494 phosphorylation site [posttranslational modification] 757424010495 intermolecular recognition site; other site 757424010496 dimerization interface [polypeptide binding]; other site 757424010497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424010498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424010499 metal binding site [ion binding]; metal-binding site 757424010500 active site 757424010501 I-site; other site 757424010502 PA14 domain; Region: PA14; cl08459 757424010503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424010504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424010505 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 757424010506 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 757424010507 nudix motif; other site 757424010508 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 757424010509 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 757424010510 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 757424010511 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 757424010512 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 757424010513 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 757424010514 quinone interaction residues [chemical binding]; other site 757424010515 active site 757424010516 catalytic residues [active] 757424010517 FMN binding site [chemical binding]; other site 757424010518 substrate binding site [chemical binding]; other site 757424010519 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 757424010520 putative active site pocket [active] 757424010521 dimerization interface [polypeptide binding]; other site 757424010522 putative catalytic residue [active] 757424010523 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 757424010524 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 757424010525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424010526 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 757424010527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424010528 Uncharacterized conserved protein [Function unknown]; Region: COG1434 757424010529 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 757424010530 putative active site [active] 757424010531 Cache domain; Region: Cache_2; pfam08269 757424010532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424010534 dimer interface [polypeptide binding]; other site 757424010535 putative CheW interface [polypeptide binding]; other site 757424010536 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 757424010537 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 757424010538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424010539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424010540 DNA binding residues [nucleotide binding] 757424010541 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 757424010542 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 757424010543 hypothetical protein; Provisional; Region: PRK05409 757424010544 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 757424010545 DoxX; Region: DoxX; pfam07681 757424010546 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424010547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424010548 S-adenosylmethionine binding site [chemical binding]; other site 757424010549 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 757424010550 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424010551 N-terminal plug; other site 757424010552 ligand-binding site [chemical binding]; other site 757424010553 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 757424010554 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 757424010555 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 757424010556 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 757424010557 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 757424010558 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 757424010559 trimer interface [polypeptide binding]; other site 757424010560 active site 757424010561 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 757424010562 haemagglutination activity domain; Region: Haemagg_act; pfam05860 757424010563 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 757424010564 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424010565 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424010566 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 757424010567 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 757424010568 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 757424010569 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 757424010570 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 757424010571 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 757424010572 active site 757424010573 homotetramer interface [polypeptide binding]; other site 757424010574 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 757424010575 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424010576 N-terminal plug; other site 757424010577 ligand-binding site [chemical binding]; other site 757424010578 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 757424010579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424010580 N-terminal plug; other site 757424010581 ligand-binding site [chemical binding]; other site 757424010582 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 757424010583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424010584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010585 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 757424010586 putative substrate binding pocket [chemical binding]; other site 757424010587 putative dimerization interface [polypeptide binding]; other site 757424010588 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 757424010589 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 757424010590 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 757424010591 active site 757424010592 metal binding site [ion binding]; metal-binding site 757424010593 dimer interface [polypeptide binding]; other site 757424010594 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 757424010595 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 757424010596 active site 757424010597 putative substrate binding pocket [chemical binding]; other site 757424010598 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 757424010599 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 757424010600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424010601 catalytic loop [active] 757424010602 iron binding site [ion binding]; other site 757424010603 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 757424010604 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 757424010605 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 757424010606 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 757424010607 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 757424010608 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 757424010609 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 757424010610 XdhC Rossmann domain; Region: XdhC_C; pfam13478 757424010611 guanine deaminase; Provisional; Region: PRK09228 757424010612 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 757424010613 active site 757424010614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424010615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424010616 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 757424010617 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424010618 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 757424010619 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424010620 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 757424010621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010622 putative substrate translocation pore; other site 757424010623 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 757424010624 MutS domain I; Region: MutS_I; pfam01624 757424010625 MutS domain II; Region: MutS_II; pfam05188 757424010626 MutS domain III; Region: MutS_III; pfam05192 757424010627 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 757424010628 Walker A/P-loop; other site 757424010629 ATP binding site [chemical binding]; other site 757424010630 Q-loop/lid; other site 757424010631 ABC transporter signature motif; other site 757424010632 Walker B; other site 757424010633 D-loop; other site 757424010634 H-loop/switch region; other site 757424010635 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 757424010636 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 757424010637 Uncharacterized conserved protein [Function unknown]; Region: COG2850 757424010638 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 757424010639 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 757424010640 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 757424010641 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 757424010642 dihydrodipicolinate synthase; Region: dapA; TIGR00674 757424010643 dimer interface [polypeptide binding]; other site 757424010644 active site 757424010645 catalytic residue [active] 757424010646 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 757424010647 active site 757424010648 HIGH motif; other site 757424010649 dimer interface [polypeptide binding]; other site 757424010650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424010651 active site 757424010652 KMSKS motif; other site 757424010653 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 757424010654 Peptidase family M50; Region: Peptidase_M50; pfam02163 757424010655 active site 757424010656 putative substrate binding region [chemical binding]; other site 757424010657 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 757424010658 heat shock protein HtpX; Provisional; Region: PRK05457 757424010659 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 757424010660 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 757424010661 active site 757424010662 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 757424010663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 757424010664 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424010665 PGAP1-like protein; Region: PGAP1; pfam07819 757424010666 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 757424010667 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 757424010668 active site 757424010669 nucleophile elbow; other site 757424010670 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 757424010671 hypothetical protein; Provisional; Region: PRK05939 757424010672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 757424010673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424010674 catalytic residue [active] 757424010675 amidophosphoribosyltransferase; Provisional; Region: PRK09246 757424010676 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 757424010677 active site 757424010678 tetramer interface [polypeptide binding]; other site 757424010679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424010680 active site 757424010681 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 757424010682 Colicin V production protein; Region: Colicin_V; pfam02674 757424010683 Sporulation related domain; Region: SPOR; pfam05036 757424010684 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 757424010685 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 757424010686 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 757424010687 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 757424010688 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 757424010689 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 757424010690 substrate binding site [chemical binding]; other site 757424010691 active site 757424010692 catalytic residues [active] 757424010693 heterodimer interface [polypeptide binding]; other site 757424010694 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 757424010695 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 757424010696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424010697 catalytic residue [active] 757424010698 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 757424010699 active site 757424010700 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 757424010701 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 757424010702 dimerization interface 3.5A [polypeptide binding]; other site 757424010703 active site 757424010704 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 757424010705 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 757424010706 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 757424010707 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 757424010708 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 757424010709 tartrate dehydrogenase; Region: TTC; TIGR02089 757424010710 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 757424010711 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 757424010712 substrate binding site [chemical binding]; other site 757424010713 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 757424010714 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 757424010715 substrate binding site [chemical binding]; other site 757424010716 ligand binding site [chemical binding]; other site 757424010717 Peptidase family M48; Region: Peptidase_M48; pfam01435 757424010718 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 757424010719 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 757424010720 Tetramer interface [polypeptide binding]; other site 757424010721 active site 757424010722 FMN-binding site [chemical binding]; other site 757424010723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010724 putative substrate translocation pore; other site 757424010725 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424010726 putative acyl-acceptor binding pocket; other site 757424010727 FOG: CBS domain [General function prediction only]; Region: COG0517 757424010728 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 757424010729 Protein of unknown function (DUF962); Region: DUF962; pfam06127 757424010730 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 757424010731 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 757424010732 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424010733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424010734 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 757424010735 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 757424010736 FAD binding domain; Region: FAD_binding_4; pfam01565 757424010737 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 757424010738 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 757424010739 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 757424010740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424010741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424010742 metal binding site [ion binding]; metal-binding site 757424010743 active site 757424010744 I-site; other site 757424010745 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424010746 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 757424010747 substrate binding site [chemical binding]; other site 757424010748 dimerization interface [polypeptide binding]; other site 757424010749 active site 757424010750 calcium binding site [ion binding]; other site 757424010751 glutathione reductase; Validated; Region: PRK06116 757424010752 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424010753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424010754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 757424010755 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 757424010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010757 dimer interface [polypeptide binding]; other site 757424010758 conserved gate region; other site 757424010759 putative PBP binding loops; other site 757424010760 ABC-ATPase subunit interface; other site 757424010761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 757424010762 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 757424010763 Walker A/P-loop; other site 757424010764 ATP binding site [chemical binding]; other site 757424010765 Q-loop/lid; other site 757424010766 ABC transporter signature motif; other site 757424010767 Walker B; other site 757424010768 D-loop; other site 757424010769 H-loop/switch region; other site 757424010770 TOBE domain; Region: TOBE_2; pfam08402 757424010771 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 757424010772 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 757424010773 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 757424010774 classical (c) SDRs; Region: SDR_c; cd05233 757424010775 NAD(P) binding site [chemical binding]; other site 757424010776 active site 757424010777 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424010778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424010779 DNA-binding site [nucleotide binding]; DNA binding site 757424010780 FCD domain; Region: FCD; pfam07729 757424010781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424010782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424010784 dimerization interface [polypeptide binding]; other site 757424010785 hypothetical protein; Provisional; Region: PRK05463 757424010786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010787 benzoate transport; Region: 2A0115; TIGR00895 757424010788 putative substrate translocation pore; other site 757424010789 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 757424010790 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 757424010791 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424010792 substrate binding pocket [chemical binding]; other site 757424010793 membrane-bound complex binding site; other site 757424010794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010795 dimer interface [polypeptide binding]; other site 757424010796 conserved gate region; other site 757424010797 putative PBP binding loops; other site 757424010798 ABC-ATPase subunit interface; other site 757424010799 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424010800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424010801 substrate binding pocket [chemical binding]; other site 757424010802 membrane-bound complex binding site; other site 757424010803 hinge residues; other site 757424010804 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424010805 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424010806 Walker A/P-loop; other site 757424010807 ATP binding site [chemical binding]; other site 757424010808 Q-loop/lid; other site 757424010809 ABC transporter signature motif; other site 757424010810 Walker B; other site 757424010811 D-loop; other site 757424010812 H-loop/switch region; other site 757424010813 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424010814 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 757424010815 putative NAD(P) binding site [chemical binding]; other site 757424010816 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 757424010817 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424010818 catalytic loop [active] 757424010819 iron binding site [ion binding]; other site 757424010820 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 757424010821 FAD binding pocket [chemical binding]; other site 757424010822 FAD binding motif [chemical binding]; other site 757424010823 phosphate binding motif [ion binding]; other site 757424010824 beta-alpha-beta structure motif; other site 757424010825 NAD binding pocket [chemical binding]; other site 757424010826 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 757424010827 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424010828 inhibitor-cofactor binding pocket; inhibition site 757424010829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424010830 catalytic residue [active] 757424010831 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 757424010832 NlpC/P60 family; Region: NLPC_P60; pfam00877 757424010833 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424010834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424010835 DNA-binding site [nucleotide binding]; DNA binding site 757424010836 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424010837 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 757424010838 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 757424010839 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 757424010840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 757424010841 dihydroxy-acid dehydratase; Validated; Region: PRK06131 757424010842 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 757424010843 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 757424010844 ligand binding site [chemical binding]; other site 757424010845 NAD binding site [chemical binding]; other site 757424010846 catalytic site [active] 757424010847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 757424010848 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 757424010849 Walker A/P-loop; other site 757424010850 ATP binding site [chemical binding]; other site 757424010851 Q-loop/lid; other site 757424010852 ABC transporter signature motif; other site 757424010853 Walker B; other site 757424010854 D-loop; other site 757424010855 H-loop/switch region; other site 757424010856 TOBE domain; Region: TOBE_2; pfam08402 757424010857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424010858 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 757424010859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010860 dimer interface [polypeptide binding]; other site 757424010861 conserved gate region; other site 757424010862 putative PBP binding loops; other site 757424010863 ABC-ATPase subunit interface; other site 757424010864 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424010865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424010866 dimer interface [polypeptide binding]; other site 757424010867 conserved gate region; other site 757424010868 putative PBP binding loops; other site 757424010869 ABC-ATPase subunit interface; other site 757424010870 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424010871 Cytochrome c; Region: Cytochrom_C; pfam00034 757424010872 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424010873 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 757424010874 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 757424010875 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424010876 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 757424010877 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 757424010878 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 757424010879 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 757424010880 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 757424010881 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424010882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424010883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424010884 dimerization interface [polypeptide binding]; other site 757424010885 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 757424010886 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 757424010887 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 757424010888 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 757424010889 DNA binding residues [nucleotide binding] 757424010890 putative dimer interface [polypeptide binding]; other site 757424010891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424010892 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424010893 active site 757424010894 catalytic tetrad [active] 757424010895 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 757424010896 active site clefts [active] 757424010897 zinc binding site [ion binding]; other site 757424010898 dimer interface [polypeptide binding]; other site 757424010899 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 757424010900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 757424010901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 757424010902 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 757424010903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010904 active site 757424010905 phosphorylation site [posttranslational modification] 757424010906 intermolecular recognition site; other site 757424010907 dimerization interface [polypeptide binding]; other site 757424010908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424010909 Walker A motif; other site 757424010910 ATP binding site [chemical binding]; other site 757424010911 Walker B motif; other site 757424010912 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424010913 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 757424010914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424010915 dimer interface [polypeptide binding]; other site 757424010916 phosphorylation site [posttranslational modification] 757424010917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424010918 ATP binding site [chemical binding]; other site 757424010919 Mg2+ binding site [ion binding]; other site 757424010920 G-X-G motif; other site 757424010921 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 757424010922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424010923 putative substrate translocation pore; other site 757424010924 malic enzyme; Reviewed; Region: PRK12862 757424010925 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 757424010926 Malic enzyme, N-terminal domain; Region: malic; pfam00390 757424010927 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 757424010928 putative NAD(P) binding site [chemical binding]; other site 757424010929 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 757424010930 thiamine monophosphate kinase; Provisional; Region: PRK05731 757424010931 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 757424010932 ATP binding site [chemical binding]; other site 757424010933 dimerization interface [polypeptide binding]; other site 757424010934 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 757424010935 tetramer interfaces [polypeptide binding]; other site 757424010936 binuclear metal-binding site [ion binding]; other site 757424010937 Competence-damaged protein; Region: CinA; pfam02464 757424010938 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 757424010939 active site 757424010940 dimer interface [polypeptide binding]; other site 757424010941 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 757424010942 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 757424010943 Repair protein; Region: Repair_PSII; pfam04536 757424010944 Repair protein; Region: Repair_PSII; pfam04536 757424010945 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 757424010946 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 757424010947 MASE2 domain; Region: MASE2; pfam05230 757424010948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424010949 metal binding site [ion binding]; metal-binding site 757424010950 active site 757424010951 I-site; other site 757424010952 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 757424010953 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 757424010954 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424010955 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 757424010956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424010957 motif II; other site 757424010958 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 757424010959 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 757424010960 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 757424010961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424010962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424010963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 757424010964 SnoaL-like domain; Region: SnoaL_2; pfam12680 757424010965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010966 active site 757424010967 phosphorylation site [posttranslational modification] 757424010968 intermolecular recognition site; other site 757424010969 dimerization interface [polypeptide binding]; other site 757424010970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424010971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424010972 dimer interface [polypeptide binding]; other site 757424010973 phosphorylation site [posttranslational modification] 757424010974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424010975 ATP binding site [chemical binding]; other site 757424010976 Mg2+ binding site [ion binding]; other site 757424010977 G-X-G motif; other site 757424010978 CheB methylesterase; Region: CheB_methylest; pfam01339 757424010979 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 757424010980 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 757424010981 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 757424010982 CHASE3 domain; Region: CHASE3; pfam05227 757424010983 GAF domain; Region: GAF_2; pfam13185 757424010984 GAF domain; Region: GAF_3; pfam13492 757424010985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424010986 dimer interface [polypeptide binding]; other site 757424010987 phosphorylation site [posttranslational modification] 757424010988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424010989 ATP binding site [chemical binding]; other site 757424010990 Mg2+ binding site [ion binding]; other site 757424010991 G-X-G motif; other site 757424010992 Response regulator receiver domain; Region: Response_reg; pfam00072 757424010993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424010994 active site 757424010995 phosphorylation site [posttranslational modification] 757424010996 intermolecular recognition site; other site 757424010997 dimerization interface [polypeptide binding]; other site 757424010998 Response regulator receiver domain; Region: Response_reg; pfam00072 757424010999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011000 active site 757424011001 phosphorylation site [posttranslational modification] 757424011002 intermolecular recognition site; other site 757424011003 Response regulator receiver domain; Region: Response_reg; pfam00072 757424011004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011005 active site 757424011006 phosphorylation site [posttranslational modification] 757424011007 intermolecular recognition site; other site 757424011008 dimerization interface [polypeptide binding]; other site 757424011009 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 757424011010 sensor protein QseC; Provisional; Region: PRK10337 757424011011 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424011012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424011013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424011014 dimer interface [polypeptide binding]; other site 757424011015 phosphorylation site [posttranslational modification] 757424011016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424011017 ATP binding site [chemical binding]; other site 757424011018 G-X-G motif; other site 757424011019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424011020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011021 active site 757424011022 phosphorylation site [posttranslational modification] 757424011023 intermolecular recognition site; other site 757424011024 dimerization interface [polypeptide binding]; other site 757424011025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424011026 DNA binding site [nucleotide binding] 757424011027 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 757424011028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424011029 N-terminal plug; other site 757424011030 ligand-binding site [chemical binding]; other site 757424011031 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 757424011032 putative transporter; Provisional; Region: PRK10504 757424011033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424011034 putative substrate translocation pore; other site 757424011035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424011036 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424011037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011038 dimer interface [polypeptide binding]; other site 757424011039 conserved gate region; other site 757424011040 putative PBP binding loops; other site 757424011041 ABC-ATPase subunit interface; other site 757424011042 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424011043 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424011044 Walker A/P-loop; other site 757424011045 ATP binding site [chemical binding]; other site 757424011046 Q-loop/lid; other site 757424011047 ABC transporter signature motif; other site 757424011048 Walker B; other site 757424011049 D-loop; other site 757424011050 H-loop/switch region; other site 757424011051 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424011052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 757424011053 substrate binding pocket [chemical binding]; other site 757424011054 membrane-bound complex binding site; other site 757424011055 hinge residues; other site 757424011056 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424011057 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 757424011058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011059 active site 757424011060 phosphorylation site [posttranslational modification] 757424011061 intermolecular recognition site; other site 757424011062 dimerization interface [polypeptide binding]; other site 757424011063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424011064 DNA binding site [nucleotide binding] 757424011065 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424011066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424011067 dimer interface [polypeptide binding]; other site 757424011068 phosphorylation site [posttranslational modification] 757424011069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424011070 ATP binding site [chemical binding]; other site 757424011071 Mg2+ binding site [ion binding]; other site 757424011072 G-X-G motif; other site 757424011073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424011074 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424011075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011076 dimer interface [polypeptide binding]; other site 757424011077 conserved gate region; other site 757424011078 putative PBP binding loops; other site 757424011079 ABC-ATPase subunit interface; other site 757424011080 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424011081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011082 dimer interface [polypeptide binding]; other site 757424011083 conserved gate region; other site 757424011084 putative PBP binding loops; other site 757424011085 ABC-ATPase subunit interface; other site 757424011086 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 757424011087 L-idonate 5-dehydrogenase; Region: PLN02702 757424011088 inhibitor binding site; inhibition site 757424011089 catalytic Zn binding site [ion binding]; other site 757424011090 structural Zn binding site [ion binding]; other site 757424011091 NADP binding site [chemical binding]; other site 757424011092 tetramer interface [polypeptide binding]; other site 757424011093 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 757424011094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424011095 Walker A/P-loop; other site 757424011096 ATP binding site [chemical binding]; other site 757424011097 Q-loop/lid; other site 757424011098 ABC transporter signature motif; other site 757424011099 Walker B; other site 757424011100 D-loop; other site 757424011101 H-loop/switch region; other site 757424011102 TOBE domain; Region: TOBE_2; pfam08402 757424011103 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 757424011104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424011105 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424011106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424011107 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 757424011108 N- and C-terminal domain interface [polypeptide binding]; other site 757424011109 active site 757424011110 MgATP binding site [chemical binding]; other site 757424011111 catalytic site [active] 757424011112 metal binding site [ion binding]; metal-binding site 757424011113 xylulose binding site [chemical binding]; other site 757424011114 homodimer interface [polypeptide binding]; other site 757424011115 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 757424011116 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424011117 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424011118 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424011119 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424011120 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 757424011121 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 757424011122 PAAR motif; Region: PAAR_motif; pfam05488 757424011123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 757424011124 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 757424011125 PemK-like protein; Region: PemK; pfam02452 757424011126 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 757424011127 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 757424011128 active site 757424011129 catalytic site [active] 757424011130 substrate binding site [chemical binding]; other site 757424011131 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 757424011132 RNA/DNA hybrid binding site [nucleotide binding]; other site 757424011133 active site 757424011134 Methyltransferase domain; Region: Methyltransf_11; pfam08241 757424011135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 757424011136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424011137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424011138 catalytic residue [active] 757424011139 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 757424011140 intersubunit interface [polypeptide binding]; other site 757424011141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 757424011142 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 757424011143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424011144 Walker A/P-loop; other site 757424011145 ATP binding site [chemical binding]; other site 757424011146 Q-loop/lid; other site 757424011147 ABC transporter signature motif; other site 757424011148 Walker B; other site 757424011149 D-loop; other site 757424011150 H-loop/switch region; other site 757424011151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 757424011152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 757424011153 Walker A/P-loop; other site 757424011154 ATP binding site [chemical binding]; other site 757424011155 Q-loop/lid; other site 757424011156 ABC transporter signature motif; other site 757424011157 Walker B; other site 757424011158 D-loop; other site 757424011159 H-loop/switch region; other site 757424011160 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 757424011161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011162 dimer interface [polypeptide binding]; other site 757424011163 conserved gate region; other site 757424011164 putative PBP binding loops; other site 757424011165 ABC-ATPase subunit interface; other site 757424011166 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 757424011167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011168 dimer interface [polypeptide binding]; other site 757424011169 conserved gate region; other site 757424011170 putative PBP binding loops; other site 757424011171 ABC-ATPase subunit interface; other site 757424011172 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 757424011173 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 757424011174 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 757424011175 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 757424011176 NAD binding site [chemical binding]; other site 757424011177 homotetramer interface [polypeptide binding]; other site 757424011178 homodimer interface [polypeptide binding]; other site 757424011179 substrate binding site [chemical binding]; other site 757424011180 active site 757424011181 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 757424011182 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 757424011183 ATP binding site [chemical binding]; other site 757424011184 Mg++ binding site [ion binding]; other site 757424011185 motif III; other site 757424011186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424011187 nucleotide binding region [chemical binding]; other site 757424011188 ATP-binding site [chemical binding]; other site 757424011189 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 757424011190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 757424011191 Protein of unknown function (DUF330); Region: DUF330; pfam03886 757424011192 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 757424011193 mce related protein; Region: MCE; pfam02470 757424011194 mce related protein; Region: MCE; pfam02470 757424011195 mce related protein; Region: MCE; pfam02470 757424011196 Paraquat-inducible protein A; Region: PqiA; pfam04403 757424011197 Paraquat-inducible protein A; Region: PqiA; pfam04403 757424011198 2-isopropylmalate synthase; Validated; Region: PRK03739 757424011199 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 757424011200 active site 757424011201 catalytic residues [active] 757424011202 metal binding site [ion binding]; metal-binding site 757424011203 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 757424011204 NnrS protein; Region: NnrS; cl01258 757424011205 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424011206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424011207 dimerization interface [polypeptide binding]; other site 757424011208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424011209 dimer interface [polypeptide binding]; other site 757424011210 putative CheW interface [polypeptide binding]; other site 757424011211 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 757424011212 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 757424011213 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 757424011214 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 757424011215 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 757424011216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424011217 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 757424011218 Walker A/P-loop; other site 757424011219 ATP binding site [chemical binding]; other site 757424011220 Q-loop/lid; other site 757424011221 ABC transporter signature motif; other site 757424011222 Walker B; other site 757424011223 D-loop; other site 757424011224 H-loop/switch region; other site 757424011225 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 757424011226 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 757424011227 active site 757424011228 FMN binding site [chemical binding]; other site 757424011229 substrate binding site [chemical binding]; other site 757424011230 homotetramer interface [polypeptide binding]; other site 757424011231 catalytic residue [active] 757424011232 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 757424011233 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 757424011234 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424011235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424011236 DNA-binding site [nucleotide binding]; DNA binding site 757424011237 FCD domain; Region: FCD; pfam07729 757424011238 short chain dehydrogenase; Provisional; Region: PRK12829 757424011239 classical (c) SDRs; Region: SDR_c; cd05233 757424011240 NAD(P) binding site [chemical binding]; other site 757424011241 active site 757424011242 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 757424011243 thymidylate synthase; Provisional; Region: thyA; PRK13821 757424011244 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 757424011245 dimerization interface [polypeptide binding]; other site 757424011246 active site 757424011247 Nitronate monooxygenase; Region: NMO; pfam03060 757424011248 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 757424011249 FMN binding site [chemical binding]; other site 757424011250 substrate binding site [chemical binding]; other site 757424011251 putative catalytic residue [active] 757424011252 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424011253 macrolide transporter subunit MacA; Provisional; Region: PRK11578 757424011254 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424011255 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 757424011256 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 757424011257 Ligand binding site; other site 757424011258 DXD motif; other site 757424011259 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 757424011260 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 757424011261 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 757424011262 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 757424011263 folate binding site [chemical binding]; other site 757424011264 NADP+ binding site [chemical binding]; other site 757424011265 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 757424011266 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 757424011267 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 757424011268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 757424011269 catalytic residue [active] 757424011270 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 757424011271 Chromate transporter; Region: Chromate_transp; pfam02417 757424011272 Chromate transporter; Region: Chromate_transp; pfam02417 757424011273 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 757424011274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011275 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 757424011276 putative dimerization interface [polypeptide binding]; other site 757424011277 putative substrate binding pocket [chemical binding]; other site 757424011278 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 757424011279 trimer interface [polypeptide binding]; other site 757424011280 active site 757424011281 SseB protein; Region: SseB; cl06279 757424011282 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 757424011283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424011284 ATP binding site [chemical binding]; other site 757424011285 putative Mg++ binding site [ion binding]; other site 757424011286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424011287 nucleotide binding region [chemical binding]; other site 757424011288 ATP-binding site [chemical binding]; other site 757424011289 Helicase associated domain (HA2); Region: HA2; pfam04408 757424011290 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 757424011291 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 757424011292 N-acetylglutamate synthase; Validated; Region: PRK05279 757424011293 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 757424011294 putative feedback inhibition sensing region; other site 757424011295 putative nucleotide binding site [chemical binding]; other site 757424011296 putative substrate binding site [chemical binding]; other site 757424011297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424011298 Coenzyme A binding pocket [chemical binding]; other site 757424011299 oxidative damage protection protein; Provisional; Region: PRK05408 757424011300 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 757424011301 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 757424011302 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 757424011303 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 757424011304 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 757424011305 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 757424011306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 757424011307 active site 757424011308 dimer interface [polypeptide binding]; other site 757424011309 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 757424011310 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 757424011311 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424011312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424011313 putative DNA binding site [nucleotide binding]; other site 757424011314 putative Zn2+ binding site [ion binding]; other site 757424011315 AsnC family; Region: AsnC_trans_reg; pfam01037 757424011316 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424011317 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 757424011318 dimerization interface [polypeptide binding]; other site 757424011319 ligand binding site [chemical binding]; other site 757424011320 Y-family of DNA polymerases; Region: PolY; cl12025 757424011321 active site 757424011322 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 757424011323 Catalytic site [active] 757424011324 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 757424011325 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 757424011326 active site 757424011327 catalytic triad [active] 757424011328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424011329 Walker A motif; other site 757424011330 ATP binding site [chemical binding]; other site 757424011331 Walker B motif; other site 757424011332 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 757424011333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 757424011334 CHASE3 domain; Region: CHASE3; cl05000 757424011335 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424011336 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424011337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424011338 dimer interface [polypeptide binding]; other site 757424011339 putative CheW interface [polypeptide binding]; other site 757424011340 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 757424011341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424011342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011344 dimerization interface [polypeptide binding]; other site 757424011345 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424011346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424011347 NAD(P) binding site [chemical binding]; other site 757424011348 active site 757424011349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424011350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424011351 short chain dehydrogenase; Provisional; Region: PRK06500 757424011352 classical (c) SDRs; Region: SDR_c; cd05233 757424011353 NAD(P) binding site [chemical binding]; other site 757424011354 active site 757424011355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424011356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424011357 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 757424011358 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 757424011359 putative NAD(P) binding site [chemical binding]; other site 757424011360 Nitronate monooxygenase; Region: NMO; pfam03060 757424011361 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 757424011362 FMN binding site [chemical binding]; other site 757424011363 substrate binding site [chemical binding]; other site 757424011364 putative catalytic residue [active] 757424011365 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 757424011366 conserved cys residue [active] 757424011367 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 757424011368 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 757424011369 conserved cys residue [active] 757424011370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424011371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424011372 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 757424011373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424011374 Predicted transcriptional regulator [Transcription]; Region: COG1959 757424011375 Transcriptional regulator; Region: Rrf2; pfam02082 757424011376 YcaO domain protein; Region: TIGR03549 757424011377 OsmC-like protein; Region: OsmC; pfam02566 757424011378 YcaO-like family; Region: YcaO; pfam02624 757424011379 Response regulator receiver domain; Region: Response_reg; pfam00072 757424011380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011381 active site 757424011382 phosphorylation site [posttranslational modification] 757424011383 intermolecular recognition site; other site 757424011384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424011385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424011386 dimer interface [polypeptide binding]; other site 757424011387 phosphorylation site [posttranslational modification] 757424011388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424011389 ATP binding site [chemical binding]; other site 757424011390 Mg2+ binding site [ion binding]; other site 757424011391 G-X-G motif; other site 757424011392 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 757424011393 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 757424011394 Predicted transcriptional regulators [Transcription]; Region: COG1695 757424011395 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 757424011396 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 757424011397 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424011398 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424011399 putative active site [active] 757424011400 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 757424011401 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 757424011402 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424011403 Walker A/P-loop; other site 757424011404 ATP binding site [chemical binding]; other site 757424011405 Q-loop/lid; other site 757424011406 ABC transporter signature motif; other site 757424011407 Walker B; other site 757424011408 D-loop; other site 757424011409 H-loop/switch region; other site 757424011410 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424011411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011412 dimer interface [polypeptide binding]; other site 757424011413 conserved gate region; other site 757424011414 putative PBP binding loops; other site 757424011415 ABC-ATPase subunit interface; other site 757424011416 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424011417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424011418 substrate binding pocket [chemical binding]; other site 757424011419 membrane-bound complex binding site; other site 757424011420 hinge residues; other site 757424011421 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424011422 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424011423 Walker A/P-loop; other site 757424011424 ATP binding site [chemical binding]; other site 757424011425 Q-loop/lid; other site 757424011426 ABC transporter signature motif; other site 757424011427 Walker B; other site 757424011428 D-loop; other site 757424011429 H-loop/switch region; other site 757424011430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011431 dimer interface [polypeptide binding]; other site 757424011432 conserved gate region; other site 757424011433 putative PBP binding loops; other site 757424011434 ABC-ATPase subunit interface; other site 757424011435 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424011436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011437 dimer interface [polypeptide binding]; other site 757424011438 conserved gate region; other site 757424011439 putative PBP binding loops; other site 757424011440 ABC-ATPase subunit interface; other site 757424011441 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 757424011442 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 757424011443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424011444 substrate binding pocket [chemical binding]; other site 757424011445 membrane-bound complex binding site; other site 757424011446 hinge residues; other site 757424011447 hypothetical protein; Provisional; Region: PRK07483 757424011448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424011449 inhibitor-cofactor binding pocket; inhibition site 757424011450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424011451 catalytic residue [active] 757424011452 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 757424011453 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 757424011454 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 757424011455 putative active site [active] 757424011456 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424011457 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424011458 dimer interface [polypeptide binding]; other site 757424011459 putative CheW interface [polypeptide binding]; other site 757424011460 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424011461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424011462 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 757424011463 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 757424011464 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 757424011465 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 757424011466 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424011467 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 757424011468 NAD(P) binding site [chemical binding]; other site 757424011469 catalytic residues [active] 757424011470 tyramine oxidase; Provisional; Region: tynA; PRK14696 757424011471 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 757424011472 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 757424011473 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 757424011474 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 757424011475 RNA polymerase sigma factor; Provisional; Region: PRK12525 757424011476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424011477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424011478 DNA binding residues [nucleotide binding] 757424011479 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 757424011480 FecR protein; Region: FecR; pfam04773 757424011481 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424011482 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424011483 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424011484 ligand-binding site [chemical binding]; other site 757424011485 Protein of unknown function (DUF535); Region: DUF535; cl01128 757424011486 flagellar capping protein; Reviewed; Region: fliD; PRK08032 757424011487 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 757424011488 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 757424011489 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 757424011490 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 757424011491 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 757424011492 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 757424011493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424011494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011496 dimerization interface [polypeptide binding]; other site 757424011497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424011498 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 757424011499 catalytic site [active] 757424011500 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 757424011501 PEP-CTERM motif; Region: VPEP; pfam07589 757424011502 Nitrate and nitrite sensing; Region: NIT; pfam08376 757424011503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424011504 dimerization interface [polypeptide binding]; other site 757424011505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424011506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424011507 dimer interface [polypeptide binding]; other site 757424011508 putative CheW interface [polypeptide binding]; other site 757424011509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424011510 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424011511 substrate binding pocket [chemical binding]; other site 757424011512 membrane-bound complex binding site; other site 757424011513 hinge residues; other site 757424011514 Predicted permeases [General function prediction only]; Region: RarD; COG2962 757424011515 Cache domain; Region: Cache_1; pfam02743 757424011516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424011517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424011518 metal binding site [ion binding]; metal-binding site 757424011519 active site 757424011520 I-site; other site 757424011521 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 757424011522 AMP binding site [chemical binding]; other site 757424011523 metal binding site [ion binding]; metal-binding site 757424011524 active site 757424011525 aminopeptidase N; Provisional; Region: pepN; PRK14015 757424011526 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 757424011527 active site 757424011528 Zn binding site [ion binding]; other site 757424011529 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 757424011530 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424011531 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 757424011532 putative ligand binding site [chemical binding]; other site 757424011533 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 757424011534 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 757424011535 NADP binding site [chemical binding]; other site 757424011536 dimer interface [polypeptide binding]; other site 757424011537 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 757424011538 EamA-like transporter family; Region: EamA; pfam00892 757424011539 EamA-like transporter family; Region: EamA; pfam00892 757424011540 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 757424011541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 757424011542 Walker A motif; other site 757424011543 ATP binding site [chemical binding]; other site 757424011544 hypothetical protein; Validated; Region: PRK00110 757424011545 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 757424011546 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 757424011547 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 757424011548 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 757424011549 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 757424011550 Mechanosensitive ion channel; Region: MS_channel; pfam00924 757424011551 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 757424011552 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 757424011553 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 757424011554 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 757424011555 active site 757424011556 (T/H)XGH motif; other site 757424011557 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 757424011558 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 757424011559 Maf-like protein; Region: Maf; pfam02545 757424011560 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 757424011561 active site 757424011562 dimer interface [polypeptide binding]; other site 757424011563 ribonuclease G; Provisional; Region: PRK11712 757424011564 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 757424011565 homodimer interface [polypeptide binding]; other site 757424011566 oligonucleotide binding site [chemical binding]; other site 757424011567 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 757424011568 O-Antigen ligase; Region: Wzy_C; pfam04932 757424011569 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 757424011570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424011571 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 757424011572 Walker A/P-loop; other site 757424011573 ATP binding site [chemical binding]; other site 757424011574 Q-loop/lid; other site 757424011575 ABC transporter signature motif; other site 757424011576 Walker B; other site 757424011577 D-loop; other site 757424011578 H-loop/switch region; other site 757424011579 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 757424011580 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 757424011581 putative active site [active] 757424011582 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 757424011583 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 757424011584 Ligand binding site; other site 757424011585 metal-binding site 757424011586 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 757424011587 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 757424011588 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 757424011589 Ligand binding site; other site 757424011590 metal-binding site 757424011591 O-Antigen ligase; Region: Wzy_C; pfam04932 757424011592 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 757424011593 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 757424011594 putative active site [active] 757424011595 putative PHP Thumb interface [polypeptide binding]; other site 757424011596 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 757424011597 generic binding surface I; other site 757424011598 generic binding surface II; other site 757424011599 rhodanese superfamily protein; Provisional; Region: PRK05320 757424011600 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 757424011601 active site residue [active] 757424011602 Flavodoxin domain; Region: Flavodoxin_5; cl17428 757424011603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424011604 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 757424011605 Pirin-related protein [General function prediction only]; Region: COG1741 757424011606 Pirin; Region: Pirin; pfam02678 757424011607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011608 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 757424011609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011610 dimerization interface [polypeptide binding]; other site 757424011611 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 757424011612 active site 757424011613 HIGH motif; other site 757424011614 nucleotide binding site [chemical binding]; other site 757424011615 active site 757424011616 KMSKS motif; other site 757424011617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 757424011618 DEAD-like helicases superfamily; Region: DEXDc; smart00487 757424011619 ATP binding site [chemical binding]; other site 757424011620 Mg++ binding site [ion binding]; other site 757424011621 motif III; other site 757424011622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424011623 nucleotide binding region [chemical binding]; other site 757424011624 ATP-binding site [chemical binding]; other site 757424011625 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 757424011626 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424011627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424011628 binding surface 757424011629 TPR repeat; Region: TPR_11; pfam13414 757424011630 TPR motif; other site 757424011631 TPR repeat; Region: TPR_11; pfam13414 757424011632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424011633 TPR motif; other site 757424011634 TPR repeat; Region: TPR_11; pfam13414 757424011635 binding surface 757424011636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424011637 binding surface 757424011638 TPR repeat; Region: TPR_11; pfam13414 757424011639 TPR motif; other site 757424011640 TPR repeat; Region: TPR_11; pfam13414 757424011641 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424011642 glucokinase; Provisional; Region: glk; PRK00292 757424011643 glucokinase, proteobacterial type; Region: glk; TIGR00749 757424011644 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 757424011645 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 757424011646 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424011647 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424011648 catalytic residue [active] 757424011649 aminotransferase; Validated; Region: PRK07337 757424011650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424011651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424011652 homodimer interface [polypeptide binding]; other site 757424011653 catalytic residue [active] 757424011654 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 757424011655 putative RNA binding site [nucleotide binding]; other site 757424011656 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 757424011657 homopentamer interface [polypeptide binding]; other site 757424011658 active site 757424011659 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 757424011660 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 757424011661 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 757424011662 dimerization interface [polypeptide binding]; other site 757424011663 active site 757424011664 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 757424011665 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 757424011666 FMN binding site [chemical binding]; other site 757424011667 active site 757424011668 catalytic residues [active] 757424011669 substrate binding site [chemical binding]; other site 757424011670 site-specific phage recombinase/integrase truncated protein 757424011671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 757424011672 DNA-binding site [nucleotide binding]; DNA binding site 757424011673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011674 AAA domain; Region: AAA_33; pfam13671 757424011675 AAA domain; Region: AAA_17; pfam13207 757424011676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 757424011677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424011678 Coenzyme A binding pocket [chemical binding]; other site 757424011679 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 757424011680 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 757424011681 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 757424011682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424011683 Helix-turn-helix domain; Region: HTH_17; cl17695 757424011684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424011685 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424011686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011688 dimerization interface [polypeptide binding]; other site 757424011689 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 757424011690 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 757424011691 putative GEF interaction site [polypeptide binding]; other site 757424011692 G1 box; other site 757424011693 GTP/Mg2+ binding site [chemical binding]; other site 757424011694 Switch I region; other site 757424011695 G2 box; other site 757424011696 G3 box; other site 757424011697 Switch II region; other site 757424011698 G4 box; other site 757424011699 G5 box; other site 757424011700 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 757424011701 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 757424011702 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 757424011703 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 757424011704 RNA binding site [nucleotide binding]; other site 757424011705 active site 757424011706 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 757424011707 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 757424011708 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 757424011709 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 757424011710 translation initiation factor IF-2; Region: IF-2; TIGR00487 757424011711 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 757424011712 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 757424011713 G1 box; other site 757424011714 putative GEF interaction site [polypeptide binding]; other site 757424011715 GTP/Mg2+ binding site [chemical binding]; other site 757424011716 Switch I region; other site 757424011717 G2 box; other site 757424011718 G3 box; other site 757424011719 Switch II region; other site 757424011720 G4 box; other site 757424011721 G5 box; other site 757424011722 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 757424011723 Translation-initiation factor 2; Region: IF-2; pfam11987 757424011724 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 757424011725 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 757424011726 NusA N-terminal domain; Region: NusA_N; pfam08529 757424011727 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 757424011728 RNA binding site [nucleotide binding]; other site 757424011729 homodimer interface [polypeptide binding]; other site 757424011730 NusA-like KH domain; Region: KH_5; pfam13184 757424011731 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 757424011732 G-X-X-G motif; other site 757424011733 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 757424011734 ribosome maturation protein RimP; Reviewed; Region: PRK00092 757424011735 Sm and related proteins; Region: Sm_like; cl00259 757424011736 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 757424011737 putative oligomer interface [polypeptide binding]; other site 757424011738 putative RNA binding site [nucleotide binding]; other site 757424011739 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 757424011740 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424011741 RNA binding surface [nucleotide binding]; other site 757424011742 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 757424011743 probable active site [active] 757424011744 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 757424011745 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 757424011746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424011747 putative active site [active] 757424011748 heme pocket [chemical binding]; other site 757424011749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424011750 putative active site [active] 757424011751 heme pocket [chemical binding]; other site 757424011752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424011753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424011754 metal binding site [ion binding]; metal-binding site 757424011755 active site 757424011756 I-site; other site 757424011757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424011758 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 757424011759 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 757424011760 active site 757424011761 FMN binding site [chemical binding]; other site 757424011762 substrate binding site [chemical binding]; other site 757424011763 3Fe-4S cluster binding site [ion binding]; other site 757424011764 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 757424011765 CPxP motif; other site 757424011766 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 757424011767 nudix motif; other site 757424011768 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 757424011769 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 757424011770 motif 1; other site 757424011771 active site 757424011772 motif 2; other site 757424011773 motif 3; other site 757424011774 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 757424011775 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 757424011776 DHHA1 domain; Region: DHHA1; pfam02272 757424011777 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 757424011778 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 757424011779 putative active site [active] 757424011780 catalytic site [active] 757424011781 putative metal binding site [ion binding]; other site 757424011782 2TM domain; Region: 2TM; pfam13239 757424011783 Histidine kinase; Region: His_kinase; pfam06580 757424011784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424011785 ATP binding site [chemical binding]; other site 757424011786 Mg2+ binding site [ion binding]; other site 757424011787 G-X-G motif; other site 757424011788 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 757424011789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011790 active site 757424011791 phosphorylation site [posttranslational modification] 757424011792 intermolecular recognition site; other site 757424011793 dimerization interface [polypeptide binding]; other site 757424011794 LytTr DNA-binding domain; Region: LytTR; smart00850 757424011795 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 757424011796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424011797 active site 757424011798 HIGH motif; other site 757424011799 nucleotide binding site [chemical binding]; other site 757424011800 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 757424011801 KMSKS motif; other site 757424011802 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 757424011803 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 757424011804 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 757424011805 Cl binding site [ion binding]; other site 757424011806 oligomer interface [polypeptide binding]; other site 757424011807 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 757424011808 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 757424011809 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 757424011810 exonuclease I; Provisional; Region: sbcB; PRK11779 757424011811 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 757424011812 active site 757424011813 catalytic site [active] 757424011814 substrate binding site [chemical binding]; other site 757424011815 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 757424011816 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 757424011817 Predicted transcriptional regulators [Transcription]; Region: COG1695 757424011818 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 757424011819 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 757424011820 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 757424011821 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 757424011822 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 757424011823 SnoaL-like domain; Region: SnoaL_4; cl17707 757424011824 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424011825 active site 757424011826 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 757424011827 Predicted metalloprotease [General function prediction only]; Region: COG2321 757424011828 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 757424011829 MAPEG family; Region: MAPEG; cl09190 757424011830 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 757424011831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424011832 putative substrate translocation pore; other site 757424011833 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 757424011834 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 757424011835 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 757424011836 [4Fe-4S] binding site [ion binding]; other site 757424011837 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 757424011838 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 757424011839 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 757424011840 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 757424011841 molybdopterin cofactor binding site; other site 757424011842 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 757424011843 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 757424011844 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 757424011845 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 757424011846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424011847 FeS/SAM binding site; other site 757424011848 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 757424011849 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 757424011850 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 757424011851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424011852 dimerization interface [polypeptide binding]; other site 757424011853 GAF domain; Region: GAF_3; pfam13492 757424011854 Histidine kinase; Region: HisKA_3; pfam07730 757424011855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424011856 ATP binding site [chemical binding]; other site 757424011857 Mg2+ binding site [ion binding]; other site 757424011858 G-X-G motif; other site 757424011859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424011860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424011861 active site 757424011862 phosphorylation site [posttranslational modification] 757424011863 intermolecular recognition site; other site 757424011864 dimerization interface [polypeptide binding]; other site 757424011865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424011866 DNA binding residues [nucleotide binding] 757424011867 dimerization interface [polypeptide binding]; other site 757424011868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 757424011869 RNA binding surface [nucleotide binding]; other site 757424011870 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 757424011871 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 757424011872 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 757424011873 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 757424011874 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 757424011875 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 757424011876 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 757424011877 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 757424011878 catalytic motif [active] 757424011879 Zn binding site [ion binding]; other site 757424011880 RibD C-terminal domain; Region: RibD_C; cl17279 757424011881 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 757424011882 Lumazine binding domain; Region: Lum_binding; pfam00677 757424011883 Lumazine binding domain; Region: Lum_binding; pfam00677 757424011884 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 757424011885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424011886 nucleophilic elbow; other site 757424011887 catalytic triad; other site 757424011888 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424011889 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424011890 Walker A/P-loop; other site 757424011891 ATP binding site [chemical binding]; other site 757424011892 Q-loop/lid; other site 757424011893 ABC transporter signature motif; other site 757424011894 Walker B; other site 757424011895 D-loop; other site 757424011896 H-loop/switch region; other site 757424011897 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424011898 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424011899 Walker A/P-loop; other site 757424011900 ATP binding site [chemical binding]; other site 757424011901 Q-loop/lid; other site 757424011902 ABC transporter signature motif; other site 757424011903 Walker B; other site 757424011904 D-loop; other site 757424011905 H-loop/switch region; other site 757424011906 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424011907 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424011908 TM-ABC transporter signature motif; other site 757424011909 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424011910 TM-ABC transporter signature motif; other site 757424011911 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424011912 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 757424011913 putative ligand binding site [chemical binding]; other site 757424011914 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 757424011915 [2Fe-2S] cluster binding site [ion binding]; other site 757424011916 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 757424011917 FMN reductase; Validated; Region: fre; PRK08051 757424011918 FAD binding pocket [chemical binding]; other site 757424011919 FAD binding motif [chemical binding]; other site 757424011920 phosphate binding motif [ion binding]; other site 757424011921 beta-alpha-beta structure motif; other site 757424011922 NAD binding pocket [chemical binding]; other site 757424011923 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 757424011924 inter-subunit interface; other site 757424011925 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 757424011926 iron-sulfur cluster [ion binding]; other site 757424011927 [2Fe-2S] cluster binding site [ion binding]; other site 757424011928 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 757424011929 putative alpha subunit interface [polypeptide binding]; other site 757424011930 putative active site [active] 757424011931 putative substrate binding site [chemical binding]; other site 757424011932 Fe binding site [ion binding]; other site 757424011933 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 757424011934 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 757424011935 octamer interface [polypeptide binding]; other site 757424011936 active site 757424011937 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 757424011938 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 757424011939 dimer interface [polypeptide binding]; other site 757424011940 active site 757424011941 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 757424011942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424011944 dimerization interface [polypeptide binding]; other site 757424011945 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424011946 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 757424011947 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 757424011948 homodimer interface [polypeptide binding]; other site 757424011949 substrate-cofactor binding pocket; other site 757424011950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424011951 catalytic residue [active] 757424011952 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 757424011953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424011954 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 757424011955 dimerization interface [polypeptide binding]; other site 757424011956 substrate binding pocket [chemical binding]; other site 757424011957 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 757424011958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424011959 putative substrate translocation pore; other site 757424011960 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 757424011961 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 757424011962 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424011963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424011964 dimer interface [polypeptide binding]; other site 757424011965 conserved gate region; other site 757424011966 putative PBP binding loops; other site 757424011967 ABC-ATPase subunit interface; other site 757424011968 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424011969 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424011970 Walker A/P-loop; other site 757424011971 ATP binding site [chemical binding]; other site 757424011972 Q-loop/lid; other site 757424011973 ABC transporter signature motif; other site 757424011974 Walker B; other site 757424011975 D-loop; other site 757424011976 H-loop/switch region; other site 757424011977 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 757424011978 NMT1-like family; Region: NMT1_2; pfam13379 757424011979 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 757424011980 CoA-transferase family III; Region: CoA_transf_3; pfam02515 757424011981 recombination protein RecR; Reviewed; Region: recR; PRK00076 757424011982 RecR protein; Region: RecR; pfam02132 757424011983 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 757424011984 putative active site [active] 757424011985 putative metal-binding site [ion binding]; other site 757424011986 tetramer interface [polypeptide binding]; other site 757424011987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 757424011988 hypothetical protein; Validated; Region: PRK00153 757424011989 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 757424011990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424011991 Walker A motif; other site 757424011992 ATP binding site [chemical binding]; other site 757424011993 Walker B motif; other site 757424011994 arginine finger; other site 757424011995 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 757424011996 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 757424011997 GAF domain; Region: GAF; pfam01590 757424011998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424011999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424012000 metal binding site [ion binding]; metal-binding site 757424012001 active site 757424012002 I-site; other site 757424012003 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 757424012004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 757424012005 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 757424012006 putative ribose interaction site [chemical binding]; other site 757424012007 putative ADP binding site [chemical binding]; other site 757424012008 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 757424012009 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 757424012010 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 757424012011 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 757424012012 tetratricopeptide repeat protein; Provisional; Region: PRK11788 757424012013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424012014 binding surface 757424012015 TPR motif; other site 757424012016 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 757424012017 IHF dimer interface [polypeptide binding]; other site 757424012018 IHF - DNA interface [nucleotide binding]; other site 757424012019 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 757424012020 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 757424012021 RNA binding site [nucleotide binding]; other site 757424012022 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 757424012023 RNA binding site [nucleotide binding]; other site 757424012024 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 757424012025 RNA binding site [nucleotide binding]; other site 757424012026 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 757424012027 RNA binding site [nucleotide binding]; other site 757424012028 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 757424012029 RNA binding site [nucleotide binding]; other site 757424012030 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 757424012031 RNA binding site [nucleotide binding]; other site 757424012032 cytidylate kinase; Provisional; Region: cmk; PRK00023 757424012033 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 757424012034 CMP-binding site; other site 757424012035 The sites determining sugar specificity; other site 757424012036 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 757424012037 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 757424012038 hinge; other site 757424012039 active site 757424012040 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 757424012041 prephenate dehydrogenase; Validated; Region: PRK08507 757424012042 Chorismate mutase type II; Region: CM_2; smart00830 757424012043 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 757424012044 Prephenate dehydratase; Region: PDT; pfam00800 757424012045 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 757424012046 putative L-Phe binding site [chemical binding]; other site 757424012047 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 757424012048 homodimer interface [polypeptide binding]; other site 757424012049 substrate-cofactor binding pocket; other site 757424012050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424012051 catalytic residue [active] 757424012052 DNA gyrase subunit A; Validated; Region: PRK05560 757424012053 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 757424012054 CAP-like domain; other site 757424012055 active site 757424012056 primary dimer interface [polypeptide binding]; other site 757424012057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 757424012063 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 757424012064 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424012065 ligand binding site [chemical binding]; other site 757424012066 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 757424012067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424012068 S-adenosylmethionine binding site [chemical binding]; other site 757424012069 phosphoglycolate phosphatase; Provisional; Region: PRK13222 757424012070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424012071 motif II; other site 757424012072 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 757424012073 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 757424012074 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 757424012075 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 757424012076 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 757424012077 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 757424012078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 757424012079 putative acyl-acceptor binding pocket; other site 757424012080 Phosphopantetheine attachment site; Region: PP-binding; cl09936 757424012081 Phosphopantetheine attachment site; Region: PP-binding; cl09936 757424012082 Predicted membrane protein [Function unknown]; Region: COG4648 757424012083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424012084 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 757424012085 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424012086 acyl-activating enzyme (AAE) consensus motif; other site 757424012087 acyl-activating enzyme (AAE) consensus motif; other site 757424012088 AMP binding site [chemical binding]; other site 757424012089 active site 757424012090 CoA binding site [chemical binding]; other site 757424012091 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 757424012092 active site 2 [active] 757424012093 dimer interface [polypeptide binding]; other site 757424012094 active site 1 [active] 757424012095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 757424012096 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 757424012097 Ligand binding site; other site 757424012098 Putative Catalytic site; other site 757424012099 DXD motif; other site 757424012100 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 757424012101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 757424012102 putative acyl-acceptor binding pocket; other site 757424012103 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 757424012104 active sites [active] 757424012105 tetramer interface [polypeptide binding]; other site 757424012106 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 757424012107 active site 757424012108 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 757424012109 Predicted exporter [General function prediction only]; Region: COG4258 757424012110 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 757424012111 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 757424012112 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 757424012113 dimer interface [polypeptide binding]; other site 757424012114 active site 757424012115 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 757424012116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424012117 NAD(P) binding site [chemical binding]; other site 757424012118 homotetramer interface [polypeptide binding]; other site 757424012119 homodimer interface [polypeptide binding]; other site 757424012120 active site 757424012121 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 757424012122 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 757424012123 dimer interface [polypeptide binding]; other site 757424012124 active site 757424012125 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 757424012126 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424012127 HAMP domain; Region: HAMP; pfam00672 757424012128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012129 dimer interface [polypeptide binding]; other site 757424012130 putative CheW interface [polypeptide binding]; other site 757424012131 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 757424012132 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 757424012133 active site 757424012134 dimer interface [polypeptide binding]; other site 757424012135 metal binding site [ion binding]; metal-binding site 757424012136 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 757424012137 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 757424012138 dimer interface [polypeptide binding]; other site 757424012139 active site 757424012140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012141 LysR family transcriptional regulator; Provisional; Region: PRK14997 757424012142 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424012143 putative effector binding pocket; other site 757424012144 dimerization interface [polypeptide binding]; other site 757424012145 MFS/sugar transport protein; Region: MFS_2; pfam13347 757424012146 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 757424012147 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 757424012148 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 757424012149 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 757424012150 DNA binding residues [nucleotide binding] 757424012151 Response regulator receiver domain; Region: Response_reg; pfam00072 757424012152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012153 active site 757424012154 phosphorylation site [posttranslational modification] 757424012155 intermolecular recognition site; other site 757424012156 dimerization interface [polypeptide binding]; other site 757424012157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424012158 dimer interface [polypeptide binding]; other site 757424012159 phosphorylation site [posttranslational modification] 757424012160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012161 ATP binding site [chemical binding]; other site 757424012162 Mg2+ binding site [ion binding]; other site 757424012163 G-X-G motif; other site 757424012164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424012165 dimer interface [polypeptide binding]; other site 757424012166 phosphorylation site [posttranslational modification] 757424012167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012168 ATP binding site [chemical binding]; other site 757424012169 Mg2+ binding site [ion binding]; other site 757424012170 G-X-G motif; other site 757424012171 Response regulator receiver domain; Region: Response_reg; pfam00072 757424012172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012173 active site 757424012174 phosphorylation site [posttranslational modification] 757424012175 intermolecular recognition site; other site 757424012176 dimerization interface [polypeptide binding]; other site 757424012177 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424012178 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424012179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424012180 dimerization interface [polypeptide binding]; other site 757424012181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012182 dimer interface [polypeptide binding]; other site 757424012183 putative CheW interface [polypeptide binding]; other site 757424012184 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 757424012185 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424012186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012187 active site 757424012188 phosphorylation site [posttranslational modification] 757424012189 intermolecular recognition site; other site 757424012190 dimerization interface [polypeptide binding]; other site 757424012191 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 757424012192 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 757424012193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424012194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424012195 PAS fold; Region: PAS_3; pfam08447 757424012196 putative active site [active] 757424012197 heme pocket [chemical binding]; other site 757424012198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424012199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 757424012200 dimer interface [polypeptide binding]; other site 757424012201 phosphorylation site [posttranslational modification] 757424012202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012203 ATP binding site [chemical binding]; other site 757424012204 Mg2+ binding site [ion binding]; other site 757424012205 G-X-G motif; other site 757424012206 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 757424012207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012208 active site 757424012209 phosphorylation site [posttranslational modification] 757424012210 intermolecular recognition site; other site 757424012211 dimerization interface [polypeptide binding]; other site 757424012212 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424012213 Zn2+ binding site [ion binding]; other site 757424012214 Mg2+ binding site [ion binding]; other site 757424012215 CHASE domain; Region: CHASE; pfam03924 757424012216 PAS fold; Region: PAS_4; pfam08448 757424012217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424012218 putative active site [active] 757424012219 heme pocket [chemical binding]; other site 757424012220 PAS fold; Region: PAS_4; pfam08448 757424012221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424012222 PAS domain; Region: PAS_9; pfam13426 757424012223 putative active site [active] 757424012224 heme pocket [chemical binding]; other site 757424012225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424012226 PAS fold; Region: PAS_3; pfam08447 757424012227 putative active site [active] 757424012228 heme pocket [chemical binding]; other site 757424012229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424012230 dimer interface [polypeptide binding]; other site 757424012231 phosphorylation site [posttranslational modification] 757424012232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012233 ATP binding site [chemical binding]; other site 757424012234 Mg2+ binding site [ion binding]; other site 757424012235 G-X-G motif; other site 757424012236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 757424012237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012238 active site 757424012239 phosphorylation site [posttranslational modification] 757424012240 intermolecular recognition site; other site 757424012241 dimerization interface [polypeptide binding]; other site 757424012242 Response regulator receiver domain; Region: Response_reg; pfam00072 757424012243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012244 active site 757424012245 phosphorylation site [posttranslational modification] 757424012246 intermolecular recognition site; other site 757424012247 dimerization interface [polypeptide binding]; other site 757424012248 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424012249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424012250 metal binding site [ion binding]; metal-binding site 757424012251 active site 757424012252 I-site; other site 757424012253 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 757424012254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 757424012255 phosphorylation site [posttranslational modification] 757424012256 intermolecular recognition site; other site 757424012257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424012258 DNA binding residues [nucleotide binding] 757424012259 dimerization interface [polypeptide binding]; other site 757424012260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424012261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424012262 metal binding site [ion binding]; metal-binding site 757424012263 active site 757424012264 I-site; other site 757424012265 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 757424012266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 757424012267 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 757424012268 Abi-like protein; Region: Abi_2; pfam07751 757424012269 short chain dehydrogenase; Provisional; Region: PRK06701 757424012270 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 757424012271 NAD binding site [chemical binding]; other site 757424012272 metal binding site [ion binding]; metal-binding site 757424012273 active site 757424012274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012275 phosphorylation site [posttranslational modification] 757424012276 intermolecular recognition site; other site 757424012277 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 757424012278 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 757424012279 metabolite-proton symporter; Region: 2A0106; TIGR00883 757424012280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012281 putative substrate translocation pore; other site 757424012282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424012283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012284 active site 757424012285 phosphorylation site [posttranslational modification] 757424012286 intermolecular recognition site; other site 757424012287 dimerization interface [polypeptide binding]; other site 757424012288 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 757424012289 DNA binding site [nucleotide binding] 757424012290 Response regulator receiver domain; Region: Response_reg; pfam00072 757424012291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012292 active site 757424012293 phosphorylation site [posttranslational modification] 757424012294 intermolecular recognition site; other site 757424012295 dimerization interface [polypeptide binding]; other site 757424012296 Response regulator receiver domain; Region: Response_reg; pfam00072 757424012297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012298 active site 757424012299 phosphorylation site [posttranslational modification] 757424012300 intermolecular recognition site; other site 757424012301 dimerization interface [polypeptide binding]; other site 757424012302 PAXNEB protein; Region: PAXNEB; pfam05625 757424012303 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 757424012304 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 757424012305 Walker A motif; other site 757424012306 Walker A motif; other site 757424012307 ATP binding site [chemical binding]; other site 757424012308 Walker B motif; other site 757424012309 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 757424012310 Walker A motif; other site 757424012311 ATP binding site [chemical binding]; other site 757424012312 Walker B motif; other site 757424012313 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424012314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424012315 dimerization interface [polypeptide binding]; other site 757424012316 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424012317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012318 dimer interface [polypeptide binding]; other site 757424012319 putative CheW interface [polypeptide binding]; other site 757424012320 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 757424012321 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 757424012322 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424012323 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424012324 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 757424012325 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 757424012326 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 757424012327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012328 metabolite-proton symporter; Region: 2A0106; TIGR00883 757424012329 putative substrate translocation pore; other site 757424012330 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424012331 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424012332 trimer interface [polypeptide binding]; other site 757424012333 eyelet of channel; other site 757424012334 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 757424012335 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 757424012336 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 757424012337 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 757424012338 shikimate binding site; other site 757424012339 NAD(P) binding site [chemical binding]; other site 757424012340 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 757424012341 dimer interface [polypeptide binding]; other site 757424012342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 757424012343 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 757424012344 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424012345 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424012346 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424012347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424012348 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424012349 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 757424012350 dimer interface [polypeptide binding]; other site 757424012351 FMN binding site [chemical binding]; other site 757424012352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424012353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012354 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424012355 putative effector binding pocket; other site 757424012356 dimerization interface [polypeptide binding]; other site 757424012357 EamA-like transporter family; Region: EamA; pfam00892 757424012358 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 757424012359 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 757424012360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012362 dimer interface [polypeptide binding]; other site 757424012363 putative CheW interface [polypeptide binding]; other site 757424012364 enoyl-CoA hydratase; Validated; Region: PRK08139 757424012365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424012366 substrate binding site [chemical binding]; other site 757424012367 oxyanion hole (OAH) forming residues; other site 757424012368 trimer interface [polypeptide binding]; other site 757424012369 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 757424012370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012371 active site 757424012372 phosphorylation site [posttranslational modification] 757424012373 intermolecular recognition site; other site 757424012374 dimerization interface [polypeptide binding]; other site 757424012375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424012376 DNA binding site [nucleotide binding] 757424012377 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 757424012378 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 757424012379 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 757424012380 Ligand Binding Site [chemical binding]; other site 757424012381 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 757424012382 GAF domain; Region: GAF_3; pfam13492 757424012383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424012384 dimer interface [polypeptide binding]; other site 757424012385 phosphorylation site [posttranslational modification] 757424012386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012387 ATP binding site [chemical binding]; other site 757424012388 Mg2+ binding site [ion binding]; other site 757424012389 G-X-G motif; other site 757424012390 K+-transporting ATPase, c chain; Region: KdpC; cl00944 757424012391 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 757424012392 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 757424012393 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 757424012394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424012395 PAS domain S-box; Region: sensory_box; TIGR00229 757424012396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424012397 putative active site [active] 757424012398 heme pocket [chemical binding]; other site 757424012399 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424012400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424012401 metal binding site [ion binding]; metal-binding site 757424012402 active site 757424012403 I-site; other site 757424012404 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 757424012405 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 757424012406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424012407 Coenzyme A binding pocket [chemical binding]; other site 757424012408 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 757424012409 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 757424012410 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 757424012411 Prostaglandin dehydrogenases; Region: PGDH; cd05288 757424012412 NAD(P) binding site [chemical binding]; other site 757424012413 substrate binding site [chemical binding]; other site 757424012414 dimer interface [polypeptide binding]; other site 757424012415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424012416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424012417 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 757424012418 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 757424012419 conserved cys residue [active] 757424012420 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 757424012421 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 757424012422 putative active site [active] 757424012423 putative metal binding site [ion binding]; other site 757424012424 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 757424012425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424012426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012427 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 757424012428 dimerization interface [polypeptide binding]; other site 757424012429 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 757424012430 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 757424012431 Walker A/P-loop; other site 757424012432 ATP binding site [chemical binding]; other site 757424012433 Q-loop/lid; other site 757424012434 ABC transporter signature motif; other site 757424012435 Walker B; other site 757424012436 D-loop; other site 757424012437 H-loop/switch region; other site 757424012438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424012439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012440 dimer interface [polypeptide binding]; other site 757424012441 conserved gate region; other site 757424012442 putative PBP binding loops; other site 757424012443 ABC-ATPase subunit interface; other site 757424012444 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 757424012445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012446 dimer interface [polypeptide binding]; other site 757424012447 conserved gate region; other site 757424012448 putative PBP binding loops; other site 757424012449 ABC-ATPase subunit interface; other site 757424012450 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 757424012451 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424012452 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 757424012453 UbiA prenyltransferase family; Region: UbiA; pfam01040 757424012454 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 757424012455 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 757424012456 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 757424012457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 757424012458 Peptidase family M23; Region: Peptidase_M23; pfam01551 757424012459 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 757424012460 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 757424012461 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 757424012462 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424012463 catalytic residue [active] 757424012464 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 757424012465 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 757424012466 Walker A motif; other site 757424012467 ATP binding site [chemical binding]; other site 757424012468 Walker B motif; other site 757424012469 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 757424012470 catalytic residues [active] 757424012471 dimer interface [polypeptide binding]; other site 757424012472 ketol-acid reductoisomerase; Provisional; Region: PRK05479 757424012473 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 757424012474 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 757424012475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424012476 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 757424012477 Walker A motif; other site 757424012478 ATP binding site [chemical binding]; other site 757424012479 Walker B motif; other site 757424012480 arginine finger; other site 757424012481 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424012482 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 757424012483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012484 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 757424012485 dimerization interface [polypeptide binding]; other site 757424012486 substrate binding pocket [chemical binding]; other site 757424012487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424012488 classical (c) SDRs; Region: SDR_c; cd05233 757424012489 NAD(P) binding site [chemical binding]; other site 757424012490 active site 757424012491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424012492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424012493 NAD(P) binding site [chemical binding]; other site 757424012494 active site 757424012495 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 757424012496 DctM-like transporters; Region: DctM; pfam06808 757424012497 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 757424012498 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 757424012499 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 757424012500 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 757424012501 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 757424012502 active site 757424012503 acyl-CoA synthetase; Validated; Region: PRK07470 757424012504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 757424012505 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 757424012506 acyl-activating enzyme (AAE) consensus motif; other site 757424012507 acyl-activating enzyme (AAE) consensus motif; other site 757424012508 putative AMP binding site [chemical binding]; other site 757424012509 putative active site [active] 757424012510 putative CoA binding site [chemical binding]; other site 757424012511 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 757424012512 trimer interface [polypeptide binding]; other site 757424012513 putative Zn binding site [ion binding]; other site 757424012514 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 757424012515 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 757424012516 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 757424012517 Cysteine-rich domain; Region: CCG; pfam02754 757424012518 Cysteine-rich domain; Region: CCG; pfam02754 757424012519 FAD binding domain; Region: FAD_binding_4; pfam01565 757424012520 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 757424012521 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 757424012522 FAD binding domain; Region: FAD_binding_4; pfam01565 757424012523 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424012524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012525 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424012526 substrate binding pocket [chemical binding]; other site 757424012527 dimerization interface [polypeptide binding]; other site 757424012528 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 757424012529 FAD binding domain; Region: FAD_binding_4; pfam01565 757424012530 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 757424012531 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 757424012532 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 757424012533 TPP-binding site; other site 757424012534 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 757424012535 PYR/PP interface [polypeptide binding]; other site 757424012536 dimer interface [polypeptide binding]; other site 757424012537 TPP binding site [chemical binding]; other site 757424012538 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 757424012539 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 757424012540 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 757424012541 substrate binding pocket [chemical binding]; other site 757424012542 chain length determination region; other site 757424012543 substrate-Mg2+ binding site; other site 757424012544 catalytic residues [active] 757424012545 aspartate-rich region 1; other site 757424012546 active site lid residues [active] 757424012547 aspartate-rich region 2; other site 757424012548 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 757424012549 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 757424012550 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 757424012551 [2Fe-2S] cluster binding site [ion binding]; other site 757424012552 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 757424012553 alpha subunit interface [polypeptide binding]; other site 757424012554 active site 757424012555 substrate binding site [chemical binding]; other site 757424012556 Fe binding site [ion binding]; other site 757424012557 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424012558 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 757424012559 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 757424012560 active site residue [active] 757424012561 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 757424012562 active site residue [active] 757424012563 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 757424012564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012565 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 757424012566 dimerization interface [polypeptide binding]; other site 757424012567 substrate binding pocket [chemical binding]; other site 757424012568 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 757424012569 ZIP Zinc transporter; Region: Zip; pfam02535 757424012570 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 757424012571 putative binding surface; other site 757424012572 active site 757424012573 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 757424012574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012575 ATP binding site [chemical binding]; other site 757424012576 Mg2+ binding site [ion binding]; other site 757424012577 G-X-G motif; other site 757424012578 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424012579 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 757424012580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012581 dimer interface [polypeptide binding]; other site 757424012582 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424012583 putative CheW interface [polypeptide binding]; other site 757424012584 CheW-like domain; Region: CheW; pfam01584 757424012585 Rubredoxin [Energy production and conversion]; Region: COG1773 757424012586 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 757424012587 iron binding site [ion binding]; other site 757424012588 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 757424012589 ATP binding site [chemical binding]; other site 757424012590 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 757424012591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424012592 inhibitor-cofactor binding pocket; inhibition site 757424012593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424012594 catalytic residue [active] 757424012595 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 757424012596 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 757424012597 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 757424012598 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 757424012599 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 757424012600 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 757424012601 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 757424012602 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 757424012603 23S rRNA interface [nucleotide binding]; other site 757424012604 L3 interface [polypeptide binding]; other site 757424012605 OsmC-like protein; Region: OsmC; cl00767 757424012606 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 757424012607 diiron binding motif [ion binding]; other site 757424012608 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 757424012609 active site 757424012610 substrate binding pocket [chemical binding]; other site 757424012611 dimer interface [polypeptide binding]; other site 757424012612 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424012613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424012614 Walker A/P-loop; other site 757424012615 ATP binding site [chemical binding]; other site 757424012616 Q-loop/lid; other site 757424012617 ABC transporter signature motif; other site 757424012618 Walker B; other site 757424012619 D-loop; other site 757424012620 H-loop/switch region; other site 757424012621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424012622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012623 dimer interface [polypeptide binding]; other site 757424012624 conserved gate region; other site 757424012625 putative PBP binding loops; other site 757424012626 ABC-ATPase subunit interface; other site 757424012627 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424012628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012629 dimer interface [polypeptide binding]; other site 757424012630 conserved gate region; other site 757424012631 putative PBP binding loops; other site 757424012632 ABC-ATPase subunit interface; other site 757424012633 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 757424012634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424012635 substrate binding pocket [chemical binding]; other site 757424012636 membrane-bound complex binding site; other site 757424012637 hinge residues; other site 757424012638 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 757424012639 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 757424012640 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 757424012641 NAD(P) binding site [chemical binding]; other site 757424012642 cell density-dependent motility repressor; Provisional; Region: PRK10082 757424012643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012644 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424012645 dimerization interface [polypeptide binding]; other site 757424012646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424012647 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 757424012648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424012649 Walker A/P-loop; other site 757424012650 ATP binding site [chemical binding]; other site 757424012651 Q-loop/lid; other site 757424012652 ABC transporter signature motif; other site 757424012653 Walker B; other site 757424012654 D-loop; other site 757424012655 H-loop/switch region; other site 757424012656 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 757424012657 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 757424012658 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 757424012659 putative ligand binding site [chemical binding]; other site 757424012660 NAD binding site [chemical binding]; other site 757424012661 catalytic site [active] 757424012662 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 757424012663 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 757424012664 acyl-activating enzyme (AAE) consensus motif; other site 757424012665 putative AMP binding site [chemical binding]; other site 757424012666 putative active site [active] 757424012667 putative CoA binding site [chemical binding]; other site 757424012668 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 757424012669 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 757424012670 putative [4Fe-4S] binding site [ion binding]; other site 757424012671 putative molybdopterin cofactor binding site [chemical binding]; other site 757424012672 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 757424012673 putative molybdopterin cofactor binding site; other site 757424012674 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 757424012675 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424012676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424012677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424012678 LysE type translocator; Region: LysE; cl00565 757424012679 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 757424012680 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 757424012681 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 757424012682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424012683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012684 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 757424012685 putative dimerization interface [polypeptide binding]; other site 757424012686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 757424012687 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424012688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012689 dimer interface [polypeptide binding]; other site 757424012690 conserved gate region; other site 757424012691 putative PBP binding loops; other site 757424012692 ABC-ATPase subunit interface; other site 757424012693 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424012694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424012695 dimer interface [polypeptide binding]; other site 757424012696 conserved gate region; other site 757424012697 putative PBP binding loops; other site 757424012698 ABC-ATPase subunit interface; other site 757424012699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424012700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424012701 Walker A/P-loop; other site 757424012702 ATP binding site [chemical binding]; other site 757424012703 Q-loop/lid; other site 757424012704 ABC transporter signature motif; other site 757424012705 Walker B; other site 757424012706 D-loop; other site 757424012707 H-loop/switch region; other site 757424012708 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424012709 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424012710 substrate binding pocket [chemical binding]; other site 757424012711 membrane-bound complex binding site; other site 757424012712 hinge residues; other site 757424012713 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 757424012714 galactarate dehydratase; Region: galactar-dH20; TIGR03248 757424012715 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 757424012716 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 757424012717 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 757424012718 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424012719 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 757424012720 NAD binding site [chemical binding]; other site 757424012721 homotetramer interface [polypeptide binding]; other site 757424012722 homodimer interface [polypeptide binding]; other site 757424012723 active site 757424012724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 757424012725 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 757424012726 enoyl-CoA hydratase; Provisional; Region: PRK05862 757424012727 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424012728 substrate binding site [chemical binding]; other site 757424012729 oxyanion hole (OAH) forming residues; other site 757424012730 trimer interface [polypeptide binding]; other site 757424012731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 757424012732 Ligand Binding Site [chemical binding]; other site 757424012733 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 757424012734 MltA specific insert domain; Region: MltA; smart00925 757424012735 3D domain; Region: 3D; pfam06725 757424012736 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 757424012737 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 757424012738 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 757424012739 substrate binding site [chemical binding]; other site 757424012740 hexamer interface [polypeptide binding]; other site 757424012741 metal binding site [ion binding]; metal-binding site 757424012742 phosphoglycolate phosphatase; Provisional; Region: PRK13222 757424012743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424012744 motif II; other site 757424012745 anthranilate synthase component I; Provisional; Region: PRK13565 757424012746 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 757424012747 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 757424012748 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 757424012749 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 757424012750 glutamine binding [chemical binding]; other site 757424012751 catalytic triad [active] 757424012752 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 757424012753 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 757424012754 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 757424012755 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 757424012756 active site 757424012757 ribulose/triose binding site [chemical binding]; other site 757424012758 phosphate binding site [ion binding]; other site 757424012759 substrate (anthranilate) binding pocket [chemical binding]; other site 757424012760 product (indole) binding pocket [chemical binding]; other site 757424012761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 757424012762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424012763 NAD(P) binding site [chemical binding]; other site 757424012764 active site 757424012765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424012766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012767 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424012768 putative effector binding pocket; other site 757424012769 dimerization interface [polypeptide binding]; other site 757424012770 putative transporter; Provisional; Region: PRK10504 757424012771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012772 putative substrate translocation pore; other site 757424012773 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 757424012774 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 757424012775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 757424012776 SCP-2 sterol transfer family; Region: SCP2; pfam02036 757424012777 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 757424012778 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 757424012779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424012780 S-adenosylmethionine binding site [chemical binding]; other site 757424012781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 757424012782 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 757424012783 nucleotide binding site/active site [active] 757424012784 HIT family signature motif; other site 757424012785 catalytic residue [active] 757424012786 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 757424012787 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 757424012788 FAD binding domain; Region: FAD_binding_4; pfam01565 757424012789 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 757424012790 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 757424012791 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 757424012792 Cysteine-rich domain; Region: CCG; pfam02754 757424012793 Cysteine-rich domain; Region: CCG; pfam02754 757424012794 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 757424012795 Predicted membrane protein [Function unknown]; Region: COG1238 757424012796 threonine dehydratase; Reviewed; Region: PRK09224 757424012797 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 757424012798 tetramer interface [polypeptide binding]; other site 757424012799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424012800 catalytic residue [active] 757424012801 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 757424012802 putative Ile/Val binding site [chemical binding]; other site 757424012803 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 757424012804 putative Ile/Val binding site [chemical binding]; other site 757424012805 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 757424012806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 757424012807 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 757424012808 Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181 757424012809 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 757424012810 active site 757424012811 phosphorylation site [posttranslational modification] 757424012812 HPr kinase/phosphorylase; Provisional; Region: PRK05428 757424012813 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 757424012814 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 757424012815 Hpr binding site; other site 757424012816 active site 757424012817 homohexamer subunit interaction site [polypeptide binding]; other site 757424012818 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 757424012819 AAA domain; Region: AAA_18; pfam13238 757424012820 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 757424012821 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 757424012822 minor groove reading motif; other site 757424012823 helix-hairpin-helix signature motif; other site 757424012824 substrate binding pocket [chemical binding]; other site 757424012825 active site 757424012826 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 757424012827 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 757424012828 DNA binding and oxoG recognition site [nucleotide binding] 757424012829 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 757424012830 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 757424012831 DNA binding site [nucleotide binding] 757424012832 catalytic residue [active] 757424012833 H2TH interface [polypeptide binding]; other site 757424012834 putative catalytic residues [active] 757424012835 turnover-facilitating residue; other site 757424012836 intercalation triad [nucleotide binding]; other site 757424012837 8OG recognition residue [nucleotide binding]; other site 757424012838 putative reading head residues; other site 757424012839 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 757424012840 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 757424012841 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 757424012842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424012843 TPR motif; other site 757424012844 Tetratricopeptide repeat; Region: TPR_16; pfam13432 757424012845 binding surface 757424012846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424012847 TPR motif; other site 757424012848 TPR repeat; Region: TPR_11; pfam13414 757424012849 binding surface 757424012850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 757424012851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424012852 binding surface 757424012853 TPR motif; other site 757424012854 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 757424012855 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 757424012856 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 757424012857 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 757424012858 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 757424012859 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 757424012860 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424012861 active site 757424012862 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 757424012863 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 757424012864 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 757424012865 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 757424012866 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 757424012867 protein binding site [polypeptide binding]; other site 757424012868 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 757424012869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424012870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424012871 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 757424012872 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 757424012873 active site 757424012874 dimer interface [polypeptide binding]; other site 757424012875 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 757424012876 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 757424012877 active site 757424012878 FMN binding site [chemical binding]; other site 757424012879 substrate binding site [chemical binding]; other site 757424012880 3Fe-4S cluster binding site [ion binding]; other site 757424012881 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 757424012882 domain interface; other site 757424012883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 757424012884 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 757424012885 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 757424012886 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 757424012887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012888 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 757424012889 putative dimerization interface [polypeptide binding]; other site 757424012890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424012891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424012892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424012893 dimerization interface [polypeptide binding]; other site 757424012894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012896 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424012897 AMP nucleosidase; Provisional; Region: PRK08292 757424012898 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 757424012899 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 757424012900 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 757424012901 active site 757424012902 homodimer interface [polypeptide binding]; other site 757424012903 homotetramer interface [polypeptide binding]; other site 757424012904 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 757424012905 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 757424012906 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 757424012907 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424012908 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424012909 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 757424012910 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 757424012911 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 757424012912 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 757424012913 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 757424012914 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424012915 inhibitor-cofactor binding pocket; inhibition site 757424012916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424012917 catalytic residue [active] 757424012918 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424012919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424012920 dimerization interface [polypeptide binding]; other site 757424012921 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424012922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424012923 dimer interface [polypeptide binding]; other site 757424012924 putative CheW interface [polypeptide binding]; other site 757424012925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424012926 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 757424012927 tetramerization interface [polypeptide binding]; other site 757424012928 NAD(P) binding site [chemical binding]; other site 757424012929 catalytic residues [active] 757424012930 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 757424012931 hypothetical protein; Provisional; Region: PRK07236 757424012932 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424012933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424012934 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424012935 Amino acid synthesis; Region: AA_synth; pfam06684 757424012936 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 757424012937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424012938 putative active site [active] 757424012939 putative metal binding site [ion binding]; other site 757424012940 VPS10 domain; Region: VPS10; smart00602 757424012941 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 757424012942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424012943 NAD(P) binding site [chemical binding]; other site 757424012944 active site 757424012945 hypothetical protein; Validated; Region: PRK07586 757424012946 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 757424012947 PYR/PP interface [polypeptide binding]; other site 757424012948 dimer interface [polypeptide binding]; other site 757424012949 TPP binding site [chemical binding]; other site 757424012950 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 757424012951 TPP-binding site [chemical binding]; other site 757424012952 dimer interface [polypeptide binding]; other site 757424012953 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 757424012954 Transcriptional regulator [Transcription]; Region: IclR; COG1414 757424012955 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424012956 Helix-turn-helix domain; Region: HTH_18; pfam12833 757424012957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424012958 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 757424012959 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424012960 NAD(P) binding site [chemical binding]; other site 757424012961 catalytic residues [active] 757424012962 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 757424012963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 757424012964 active site 757424012965 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 757424012966 dimer interface [polypeptide binding]; other site 757424012967 substrate binding site [chemical binding]; other site 757424012968 catalytic residues [active] 757424012969 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 757424012970 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 757424012971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424012972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424012973 active site 757424012974 phosphorylation site [posttranslational modification] 757424012975 intermolecular recognition site; other site 757424012976 dimerization interface [polypeptide binding]; other site 757424012977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424012978 DNA binding site [nucleotide binding] 757424012979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424012980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424012981 dimerization interface [polypeptide binding]; other site 757424012982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424012983 dimer interface [polypeptide binding]; other site 757424012984 phosphorylation site [posttranslational modification] 757424012985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424012986 ATP binding site [chemical binding]; other site 757424012987 Mg2+ binding site [ion binding]; other site 757424012988 G-X-G motif; other site 757424012989 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424012990 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424012991 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 757424012992 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 757424012993 dimer interface [polypeptide binding]; other site 757424012994 ssDNA binding site [nucleotide binding]; other site 757424012995 tetramer (dimer of dimers) interface [polypeptide binding]; other site 757424012996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424012997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424012998 putative substrate translocation pore; other site 757424012999 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 757424013000 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 757424013001 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 757424013002 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 757424013003 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 757424013004 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 757424013005 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 757424013006 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424013007 Tar ligand binding domain homologue; Region: TarH; pfam02203 757424013008 HAMP domain; Region: HAMP; pfam00672 757424013009 dimerization interface [polypeptide binding]; other site 757424013010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424013011 dimer interface [polypeptide binding]; other site 757424013012 putative CheW interface [polypeptide binding]; other site 757424013013 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 757424013014 putative cation:proton antiport protein; Provisional; Region: PRK10669 757424013015 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 757424013016 TrkA-N domain; Region: TrkA_N; pfam02254 757424013017 TrkA-C domain; Region: TrkA_C; pfam02080 757424013018 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 757424013019 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 757424013020 putative active site [active] 757424013021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 757424013022 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 757424013023 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 757424013024 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 757424013025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 757424013026 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 757424013027 OstA-like protein; Region: OstA; pfam03968 757424013028 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 757424013029 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 757424013030 Walker A/P-loop; other site 757424013031 ATP binding site [chemical binding]; other site 757424013032 Q-loop/lid; other site 757424013033 ABC transporter signature motif; other site 757424013034 Walker B; other site 757424013035 D-loop; other site 757424013036 H-loop/switch region; other site 757424013037 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 757424013038 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 757424013039 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 757424013040 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 757424013041 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 757424013042 30S subunit binding site; other site 757424013043 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 757424013044 putative GSH binding site [chemical binding]; other site 757424013045 catalytic residues [active] 757424013046 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 757424013047 Flavoprotein; Region: Flavoprotein; pfam02441 757424013048 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 757424013049 classical (c) SDRs; Region: SDR_c; cd05233 757424013050 NAD(P) binding site [chemical binding]; other site 757424013051 active site 757424013052 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 757424013053 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 757424013054 dimer interface [polypeptide binding]; other site 757424013055 TPP-binding site [chemical binding]; other site 757424013056 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 757424013057 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424013058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424013059 putative DNA binding site [nucleotide binding]; other site 757424013060 putative Zn2+ binding site [ion binding]; other site 757424013061 AsnC family; Region: AsnC_trans_reg; pfam01037 757424013062 Response regulator receiver domain; Region: Response_reg; pfam00072 757424013063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424013064 active site 757424013065 phosphorylation site [posttranslational modification] 757424013066 intermolecular recognition site; other site 757424013067 dimerization interface [polypeptide binding]; other site 757424013068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424013069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424013070 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 757424013071 CAAX protease self-immunity; Region: Abi; pfam02517 757424013072 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 757424013073 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 757424013074 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 757424013075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424013076 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 757424013077 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424013078 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424013079 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 757424013080 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 757424013081 active site 757424013082 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 757424013083 active site 757424013084 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 757424013085 adenylosuccinate lyase; Region: purB; TIGR00928 757424013086 tetramer interface [polypeptide binding]; other site 757424013087 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 757424013088 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424013089 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 757424013090 catalytic site [active] 757424013091 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424013092 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424013093 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 757424013094 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 757424013095 FMN-binding pocket [chemical binding]; other site 757424013096 flavin binding motif; other site 757424013097 phosphate binding motif [ion binding]; other site 757424013098 beta-alpha-beta structure motif; other site 757424013099 NAD binding pocket [chemical binding]; other site 757424013100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424013101 catalytic loop [active] 757424013102 iron binding site [ion binding]; other site 757424013103 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 757424013104 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 757424013105 iron-sulfur cluster [ion binding]; other site 757424013106 [2Fe-2S] cluster binding site [ion binding]; other site 757424013107 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 757424013108 alpha subunit interface [polypeptide binding]; other site 757424013109 active site 757424013110 substrate binding site [chemical binding]; other site 757424013111 Fe binding site [ion binding]; other site 757424013112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424013113 MarR family; Region: MarR; pfam01047 757424013114 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 757424013115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424013116 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 757424013117 substrate binding pocket [chemical binding]; other site 757424013118 dimerization interface [polypeptide binding]; other site 757424013119 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 757424013120 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 757424013121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424013122 Zn2+ binding site [ion binding]; other site 757424013123 Mg2+ binding site [ion binding]; other site 757424013124 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424013125 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424013126 Walker A/P-loop; other site 757424013127 ATP binding site [chemical binding]; other site 757424013128 Q-loop/lid; other site 757424013129 ABC transporter signature motif; other site 757424013130 Walker B; other site 757424013131 D-loop; other site 757424013132 H-loop/switch region; other site 757424013133 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424013134 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424013135 Walker A/P-loop; other site 757424013136 ATP binding site [chemical binding]; other site 757424013137 Q-loop/lid; other site 757424013138 ABC transporter signature motif; other site 757424013139 Walker B; other site 757424013140 D-loop; other site 757424013141 H-loop/switch region; other site 757424013142 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424013143 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424013144 TM-ABC transporter signature motif; other site 757424013145 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424013146 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424013147 TM-ABC transporter signature motif; other site 757424013148 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 757424013149 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424013150 dimer interface [polypeptide binding]; other site 757424013151 active site 757424013152 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 757424013153 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 757424013154 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 757424013155 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 757424013156 Bacterial transcriptional regulator; Region: IclR; pfam01614 757424013157 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424013158 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424013159 trimer interface [polypeptide binding]; other site 757424013160 eyelet of channel; other site 757424013161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424013162 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424013163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424013164 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 757424013165 substrate binding site [chemical binding]; other site 757424013166 oxyanion hole (OAH) forming residues; other site 757424013167 trimer interface [polypeptide binding]; other site 757424013168 feruloyl-CoA synthase; Reviewed; Region: PRK08180 757424013169 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 757424013170 acyl-activating enzyme (AAE) consensus motif; other site 757424013171 putative AMP binding site [chemical binding]; other site 757424013172 putative active site [active] 757424013173 putative CoA binding site [chemical binding]; other site 757424013174 putative acyltransferase; Provisional; Region: PRK05790 757424013175 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424013176 dimer interface [polypeptide binding]; other site 757424013177 active site 757424013178 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 757424013179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424013180 NAD(P) binding site [chemical binding]; other site 757424013181 active site 757424013182 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 757424013183 active site 757424013184 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424013185 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 757424013186 putative ligand binding site [chemical binding]; other site 757424013187 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424013188 TM-ABC transporter signature motif; other site 757424013189 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424013190 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424013191 TM-ABC transporter signature motif; other site 757424013192 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424013193 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424013194 Walker A/P-loop; other site 757424013195 ATP binding site [chemical binding]; other site 757424013196 Q-loop/lid; other site 757424013197 ABC transporter signature motif; other site 757424013198 Walker B; other site 757424013199 D-loop; other site 757424013200 H-loop/switch region; other site 757424013201 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424013202 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424013203 Walker A/P-loop; other site 757424013204 ATP binding site [chemical binding]; other site 757424013205 Q-loop/lid; other site 757424013206 ABC transporter signature motif; other site 757424013207 Walker B; other site 757424013208 D-loop; other site 757424013209 H-loop/switch region; other site 757424013210 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 757424013211 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 757424013212 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 757424013213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424013214 active site 757424013215 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 757424013216 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424013217 MarR family; Region: MarR; pfam01047 757424013218 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 757424013219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424013220 dimerization interface [polypeptide binding]; other site 757424013221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424013222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424013223 dimer interface [polypeptide binding]; other site 757424013224 putative CheW interface [polypeptide binding]; other site 757424013225 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 757424013226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424013227 TM-ABC transporter signature motif; other site 757424013228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424013229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424013230 TM-ABC transporter signature motif; other site 757424013231 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424013232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424013233 Walker A/P-loop; other site 757424013234 ATP binding site [chemical binding]; other site 757424013235 Q-loop/lid; other site 757424013236 ABC transporter signature motif; other site 757424013237 Walker B; other site 757424013238 D-loop; other site 757424013239 H-loop/switch region; other site 757424013240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424013241 Walker A/P-loop; other site 757424013242 ATP binding site [chemical binding]; other site 757424013243 Q-loop/lid; other site 757424013244 ABC transporter signature motif; other site 757424013245 Walker B; other site 757424013246 D-loop; other site 757424013247 H-loop/switch region; other site 757424013248 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 757424013249 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424013250 putative ligand binding site [chemical binding]; other site 757424013251 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424013252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424013253 dimerization interface [polypeptide binding]; other site 757424013254 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424013255 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424013256 dimer interface [polypeptide binding]; other site 757424013257 putative CheW interface [polypeptide binding]; other site 757424013258 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 757424013259 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 757424013260 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 757424013261 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 757424013262 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 757424013263 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 757424013264 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 757424013265 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424013266 ligand binding site [chemical binding]; other site 757424013267 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 757424013268 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 757424013269 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 757424013270 Clp amino terminal domain; Region: Clp_N; pfam02861 757424013271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424013272 Walker A motif; other site 757424013273 ATP binding site [chemical binding]; other site 757424013274 Walker B motif; other site 757424013275 arginine finger; other site 757424013276 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 757424013277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424013278 Walker A motif; other site 757424013279 ATP binding site [chemical binding]; other site 757424013280 Walker B motif; other site 757424013281 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 757424013282 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 757424013283 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 757424013284 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 757424013285 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 757424013286 Protein of unknown function (DUF796); Region: DUF796; pfam05638 757424013287 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 757424013288 Protein of unknown function (DUF877); Region: DUF877; pfam05943 757424013289 Protein of unknown function (DUF770); Region: DUF770; pfam05591 757424013290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424013291 Tetratricopeptide repeat; Region: TPR_16; pfam13432 757424013292 binding surface 757424013293 TPR motif; other site 757424013294 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 757424013295 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 757424013296 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 757424013297 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 757424013298 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424013299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424013300 metal binding site [ion binding]; metal-binding site 757424013301 active site 757424013302 I-site; other site 757424013303 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 757424013304 stringent starvation protein A; Provisional; Region: sspA; PRK09481 757424013305 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 757424013306 C-terminal domain interface [polypeptide binding]; other site 757424013307 putative GSH binding site (G-site) [chemical binding]; other site 757424013308 dimer interface [polypeptide binding]; other site 757424013309 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 757424013310 dimer interface [polypeptide binding]; other site 757424013311 N-terminal domain interface [polypeptide binding]; other site 757424013312 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 757424013313 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 757424013314 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 757424013315 Qi binding site; other site 757424013316 intrachain domain interface; other site 757424013317 interchain domain interface [polypeptide binding]; other site 757424013318 heme bH binding site [chemical binding]; other site 757424013319 heme bL binding site [chemical binding]; other site 757424013320 Qo binding site; other site 757424013321 interchain domain interface [polypeptide binding]; other site 757424013322 intrachain domain interface; other site 757424013323 Qi binding site; other site 757424013324 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 757424013325 Qo binding site; other site 757424013326 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 757424013327 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 757424013328 [2Fe-2S] cluster binding site [ion binding]; other site 757424013329 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 757424013330 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 757424013331 Uncharacterized conserved protein [Function unknown]; Region: COG0327 757424013332 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 757424013333 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 757424013334 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424013335 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 757424013336 protein binding site [polypeptide binding]; other site 757424013337 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 757424013338 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424013339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424013340 DNA-binding site [nucleotide binding]; DNA binding site 757424013341 FCD domain; Region: FCD; pfam07729 757424013342 D-lactate dehydrogenase; Provisional; Region: PRK11183 757424013343 FAD binding domain; Region: FAD_binding_4; pfam01565 757424013344 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 757424013345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424013346 D-galactonate transporter; Region: 2A0114; TIGR00893 757424013347 putative substrate translocation pore; other site 757424013348 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 757424013349 sec-independent translocase; Provisional; Region: tatB; PRK01919 757424013350 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 757424013351 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 757424013352 nucleotide binding site/active site [active] 757424013353 HIT family signature motif; other site 757424013354 catalytic residue [active] 757424013355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 757424013356 metal binding site [ion binding]; metal-binding site 757424013357 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 757424013358 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 757424013359 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 757424013360 substrate binding site [chemical binding]; other site 757424013361 glutamase interaction surface [polypeptide binding]; other site 757424013362 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 757424013363 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 757424013364 catalytic residues [active] 757424013365 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 757424013366 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 757424013367 putative active site [active] 757424013368 oxyanion strand; other site 757424013369 catalytic triad [active] 757424013370 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 757424013371 putative active site pocket [active] 757424013372 4-fold oligomerization interface [polypeptide binding]; other site 757424013373 metal binding residues [ion binding]; metal-binding site 757424013374 3-fold/trimer interface [polypeptide binding]; other site 757424013375 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 757424013376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424013377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424013378 homodimer interface [polypeptide binding]; other site 757424013379 catalytic residue [active] 757424013380 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 757424013381 DNA methylase; Region: N6_N4_Mtase; pfam01555 757424013382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424013383 S-adenosylmethionine binding site [chemical binding]; other site 757424013384 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 757424013385 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 757424013386 NAD binding site [chemical binding]; other site 757424013387 dimerization interface [polypeptide binding]; other site 757424013388 product binding site; other site 757424013389 substrate binding site [chemical binding]; other site 757424013390 zinc binding site [ion binding]; other site 757424013391 catalytic residues [active] 757424013392 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 757424013393 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 757424013394 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 757424013395 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 757424013396 hinge; other site 757424013397 active site 757424013398 ABC-2 type transporter; Region: ABC2_membrane; cl17235 757424013399 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 757424013400 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 757424013401 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 757424013402 Walker A/P-loop; other site 757424013403 ATP binding site [chemical binding]; other site 757424013404 Q-loop/lid; other site 757424013405 ABC transporter signature motif; other site 757424013406 Walker B; other site 757424013407 D-loop; other site 757424013408 H-loop/switch region; other site 757424013409 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 757424013410 VacJ like lipoprotein; Region: VacJ; cl01073 757424013411 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 757424013412 mce related protein; Region: MCE; pfam02470 757424013413 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 757424013414 Permease; Region: Permease; pfam02405 757424013415 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 757424013416 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 757424013417 Walker A/P-loop; other site 757424013418 ATP binding site [chemical binding]; other site 757424013419 Q-loop/lid; other site 757424013420 ABC transporter signature motif; other site 757424013421 Walker B; other site 757424013422 D-loop; other site 757424013423 H-loop/switch region; other site 757424013424 GTP-binding protein YchF; Reviewed; Region: PRK09601 757424013425 YchF GTPase; Region: YchF; cd01900 757424013426 G1 box; other site 757424013427 GTP/Mg2+ binding site [chemical binding]; other site 757424013428 Switch I region; other site 757424013429 G2 box; other site 757424013430 Switch II region; other site 757424013431 G3 box; other site 757424013432 G4 box; other site 757424013433 G5 box; other site 757424013434 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 757424013435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424013436 non-specific DNA binding site [nucleotide binding]; other site 757424013437 salt bridge; other site 757424013438 sequence-specific DNA binding site [nucleotide binding]; other site 757424013439 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 757424013440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 757424013441 non-specific DNA binding site [nucleotide binding]; other site 757424013442 salt bridge; other site 757424013443 sequence-specific DNA binding site [nucleotide binding]; other site 757424013444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424013445 ATP binding site [chemical binding]; other site 757424013446 Mg2+ binding site [ion binding]; other site 757424013447 G-X-G motif; other site 757424013448 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 757424013449 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 757424013450 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 757424013451 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 757424013452 Fic family protein [Function unknown]; Region: COG3177 757424013453 HipA N-terminal domain; Region: Couple_hipA; cl11853 757424013454 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 757424013455 HipA-like N-terminal domain; Region: HipA_N; pfam07805 757424013456 HipA-like C-terminal domain; Region: HipA_C; pfam07804 757424013457 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 757424013458 active site 757424013459 catalytic residues [active] 757424013460 DNA binding site [nucleotide binding] 757424013461 Int/Topo IB signature motif; other site 757424013462 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 757424013463 DNA binding site [nucleotide binding] 757424013464 Int/Topo IB signature motif; other site 757424013465 active site 757424013466 catalytic residues [active] 757424013467 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 757424013468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424013469 D-galactonate transporter; Region: 2A0114; TIGR00893 757424013470 putative substrate translocation pore; other site 757424013471 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 757424013472 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 757424013473 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 757424013474 putative active site [active] 757424013475 putative catalytic site [active] 757424013476 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424013477 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424013478 trimer interface [polypeptide binding]; other site 757424013479 eyelet of channel; other site 757424013480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424013481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424013482 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 757424013483 putative substrate binding pocket [chemical binding]; other site 757424013484 dimerization interface [polypeptide binding]; other site 757424013485 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 757424013486 putative active site [active] 757424013487 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 757424013488 carboxyltransferase (CT) interaction site; other site 757424013489 biotinylation site [posttranslational modification]; other site 757424013490 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 757424013491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424013492 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424013493 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 757424013494 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 757424013495 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 757424013496 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 757424013497 Fic family protein [Function unknown]; Region: COG3177 757424013498 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 757424013499 Fic/DOC family; Region: Fic; pfam02661 757424013500 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424013501 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424013502 Walker A/P-loop; other site 757424013503 ATP binding site [chemical binding]; other site 757424013504 Q-loop/lid; other site 757424013505 ABC transporter signature motif; other site 757424013506 Walker B; other site 757424013507 D-loop; other site 757424013508 H-loop/switch region; other site 757424013509 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424013510 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424013511 TM-ABC transporter signature motif; other site 757424013512 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424013513 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424013514 Walker A/P-loop; other site 757424013515 ATP binding site [chemical binding]; other site 757424013516 Q-loop/lid; other site 757424013517 ABC transporter signature motif; other site 757424013518 Walker B; other site 757424013519 D-loop; other site 757424013520 H-loop/switch region; other site 757424013521 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424013522 TM-ABC transporter signature motif; other site 757424013523 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 757424013524 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 757424013525 substrate binding site [chemical binding]; other site 757424013526 dimer interface [polypeptide binding]; other site 757424013527 NADP binding site [chemical binding]; other site 757424013528 catalytic residues [active] 757424013529 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 757424013530 substrate binding site [chemical binding]; other site 757424013531 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 757424013532 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 757424013533 putative ligand binding site [chemical binding]; other site 757424013534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424013535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424013536 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 757424013537 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 757424013538 putative trimer interface [polypeptide binding]; other site 757424013539 putative metal binding site [ion binding]; other site 757424013540 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 757424013541 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 757424013542 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 757424013543 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 757424013544 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 757424013545 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 757424013546 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 757424013547 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 757424013548 FAD binding pocket [chemical binding]; other site 757424013549 FAD binding motif [chemical binding]; other site 757424013550 phosphate binding motif [ion binding]; other site 757424013551 beta-alpha-beta structure motif; other site 757424013552 NAD(p) ribose binding residues [chemical binding]; other site 757424013553 NAD binding pocket [chemical binding]; other site 757424013554 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 757424013555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424013556 catalytic loop [active] 757424013557 iron binding site [ion binding]; other site 757424013558 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 757424013559 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 757424013560 NAD(P) binding site [chemical binding]; other site 757424013561 catalytic residues [active] 757424013562 enoyl-CoA hydratase; Provisional; Region: PRK08140 757424013563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424013564 substrate binding site [chemical binding]; other site 757424013565 oxyanion hole (OAH) forming residues; other site 757424013566 trimer interface [polypeptide binding]; other site 757424013567 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 757424013568 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 757424013569 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 757424013570 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 757424013571 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 757424013572 CoenzymeA binding site [chemical binding]; other site 757424013573 subunit interaction site [polypeptide binding]; other site 757424013574 PHB binding site; other site 757424013575 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 757424013576 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 757424013577 active site 757424013578 AMP binding site [chemical binding]; other site 757424013579 homodimer interface [polypeptide binding]; other site 757424013580 acyl-activating enzyme (AAE) consensus motif; other site 757424013581 CoA binding site [chemical binding]; other site 757424013582 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 757424013583 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 757424013584 dimer interface [polypeptide binding]; other site 757424013585 active site 757424013586 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 757424013587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 757424013588 substrate binding site [chemical binding]; other site 757424013589 oxyanion hole (OAH) forming residues; other site 757424013590 trimer interface [polypeptide binding]; other site 757424013591 Methyltransferase domain; Region: Methyltransf_32; pfam13679 757424013592 Methyltransferase domain; Region: Methyltransf_31; pfam13847 757424013593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424013594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424013595 metal binding site [ion binding]; metal-binding site 757424013596 active site 757424013597 I-site; other site 757424013598 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 757424013599 EamA-like transporter family; Region: EamA; pfam00892 757424013600 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 757424013601 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 757424013602 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 757424013603 active site 757424013604 (T/H)XGH motif; other site 757424013605 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 757424013606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424013607 S-adenosylmethionine binding site [chemical binding]; other site 757424013608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 757424013609 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 757424013610 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 757424013611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 757424013612 P-loop; other site 757424013613 Magnesium ion binding site [ion binding]; other site 757424013614 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 757424013615 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 757424013616 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 757424013617 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 757424013618 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 757424013619 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 757424013620 P loop; other site 757424013621 GTP binding site [chemical binding]; other site 757424013622 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 757424013623 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 757424013624 Walker A/P-loop; other site 757424013625 ATP binding site [chemical binding]; other site 757424013626 Q-loop/lid; other site 757424013627 ABC transporter signature motif; other site 757424013628 Walker B; other site 757424013629 D-loop; other site 757424013630 H-loop/switch region; other site 757424013631 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 757424013632 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 757424013633 Abi-like protein; Region: Abi_2; pfam07751 757424013634 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 757424013635 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 757424013636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424013637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424013638 DNA binding residues [nucleotide binding] 757424013639 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 757424013640 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 757424013641 Cu(I) binding site [ion binding]; other site 757424013642 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 757424013643 UbiA prenyltransferase family; Region: UbiA; pfam01040 757424013644 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 757424013645 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 757424013646 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 757424013647 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 757424013648 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 757424013649 Subunit III/VIIa interface [polypeptide binding]; other site 757424013650 Phospholipid binding site [chemical binding]; other site 757424013651 Subunit I/III interface [polypeptide binding]; other site 757424013652 Subunit III/VIb interface [polypeptide binding]; other site 757424013653 Subunit III/VIa interface; other site 757424013654 Subunit III/Vb interface [polypeptide binding]; other site 757424013655 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 757424013656 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 757424013657 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 757424013658 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 757424013659 Subunit I/III interface [polypeptide binding]; other site 757424013660 D-pathway; other site 757424013661 Subunit I/VIIc interface [polypeptide binding]; other site 757424013662 Subunit I/IV interface [polypeptide binding]; other site 757424013663 Subunit I/II interface [polypeptide binding]; other site 757424013664 Low-spin heme (heme a) binding site [chemical binding]; other site 757424013665 Subunit I/VIIa interface [polypeptide binding]; other site 757424013666 Subunit I/VIa interface [polypeptide binding]; other site 757424013667 Dimer interface; other site 757424013668 Putative water exit pathway; other site 757424013669 Binuclear center (heme a3/CuB) [ion binding]; other site 757424013670 K-pathway; other site 757424013671 Subunit I/Vb interface [polypeptide binding]; other site 757424013672 Putative proton exit pathway; other site 757424013673 Subunit I/VIb interface; other site 757424013674 Subunit I/VIc interface [polypeptide binding]; other site 757424013675 Electron transfer pathway; other site 757424013676 Subunit I/VIIIb interface [polypeptide binding]; other site 757424013677 Subunit I/VIIb interface [polypeptide binding]; other site 757424013678 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 757424013679 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 757424013680 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 757424013681 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424013682 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 757424013683 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 757424013684 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 757424013685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424013686 S-adenosylmethionine binding site [chemical binding]; other site 757424013687 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 757424013688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424013689 active site 757424013690 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 757424013691 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 757424013692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 757424013693 Walker A/P-loop; other site 757424013694 ATP binding site [chemical binding]; other site 757424013695 Q-loop/lid; other site 757424013696 ABC transporter signature motif; other site 757424013697 Walker B; other site 757424013698 D-loop; other site 757424013699 H-loop/switch region; other site 757424013700 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424013701 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 757424013702 TM-ABC transporter signature motif; other site 757424013703 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 757424013704 zinc binding site [ion binding]; other site 757424013705 putative ligand binding site [chemical binding]; other site 757424013706 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 757424013707 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 757424013708 zinc binding site [ion binding]; other site 757424013709 putative ligand binding site [chemical binding]; other site 757424013710 Protein of unknown function (DUF461); Region: DUF461; pfam04314 757424013711 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 757424013712 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 757424013713 active site 757424013714 nucleotide binding site [chemical binding]; other site 757424013715 HIGH motif; other site 757424013716 KMSKS motif; other site 757424013717 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 757424013718 dinuclear metal binding motif [ion binding]; other site 757424013719 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424013720 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 757424013721 putative ligand binding site [chemical binding]; other site 757424013722 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 757424013723 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 757424013724 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 757424013725 Ligand Binding Site [chemical binding]; other site 757424013726 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 757424013727 Beta-lactamase; Region: Beta-lactamase; pfam00144 757424013728 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 757424013729 Transglycosylase; Region: Transgly; pfam00912 757424013730 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 757424013731 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 757424013732 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 757424013733 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424013734 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 757424013735 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 757424013736 shikimate kinase; Reviewed; Region: aroK; PRK00131 757424013737 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 757424013738 ADP binding site [chemical binding]; other site 757424013739 magnesium binding site [ion binding]; other site 757424013740 putative shikimate binding site; other site 757424013741 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 757424013742 active site 757424013743 dimer interface [polypeptide binding]; other site 757424013744 metal binding site [ion binding]; metal-binding site 757424013745 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 757424013746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424013747 Zn2+ binding site [ion binding]; other site 757424013748 Mg2+ binding site [ion binding]; other site 757424013749 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 757424013750 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 757424013751 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 757424013752 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 757424013753 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 757424013754 RNA binding site [nucleotide binding]; other site 757424013755 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 757424013756 putative active site [active] 757424013757 catalytic residue [active] 757424013758 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 757424013759 dimerization domain [polypeptide binding]; other site 757424013760 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 757424013761 dimer interface [polypeptide binding]; other site 757424013762 catalytic residues [active] 757424013763 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 757424013764 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 757424013765 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 757424013766 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 757424013767 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 757424013768 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 757424013769 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 757424013770 NAD binding site [chemical binding]; other site 757424013771 substrate binding site [chemical binding]; other site 757424013772 homodimer interface [polypeptide binding]; other site 757424013773 active site 757424013774 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 757424013775 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 757424013776 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 757424013777 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 757424013778 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 757424013779 putative trimer interface [polypeptide binding]; other site 757424013780 putative active site [active] 757424013781 putative substrate binding site [chemical binding]; other site 757424013782 putative CoA binding site [chemical binding]; other site 757424013783 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 757424013784 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 757424013785 inhibitor-cofactor binding pocket; inhibition site 757424013786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424013787 catalytic residue [active] 757424013788 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 757424013789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424013790 NAD(P) binding site [chemical binding]; other site 757424013791 active site 757424013792 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 757424013793 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 757424013794 inhibitor-cofactor binding pocket; inhibition site 757424013795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424013796 catalytic residue [active] 757424013797 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 757424013798 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 757424013799 active site 757424013800 dimer interface [polypeptide binding]; other site 757424013801 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 757424013802 Ligand Binding Site [chemical binding]; other site 757424013803 Molecular Tunnel; other site 757424013804 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 757424013805 trimer interface [polypeptide binding]; other site 757424013806 active site 757424013807 substrate binding site [chemical binding]; other site 757424013808 CoA binding site [chemical binding]; other site 757424013809 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 757424013810 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 757424013811 Ligand Binding Site [chemical binding]; other site 757424013812 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 757424013813 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 757424013814 putative active site [active] 757424013815 oxyanion strand; other site 757424013816 catalytic triad [active] 757424013817 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 757424013818 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 757424013819 substrate binding site [chemical binding]; other site 757424013820 glutamase interaction surface [polypeptide binding]; other site 757424013821 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 757424013822 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 757424013823 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 757424013824 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 757424013825 putative trimer interface [polypeptide binding]; other site 757424013826 putative CoA binding site [chemical binding]; other site 757424013827 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 757424013828 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 757424013829 dimer interface [polypeptide binding]; other site 757424013830 active site 757424013831 CoA binding pocket [chemical binding]; other site 757424013832 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 757424013833 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 757424013834 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 757424013835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424013836 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 757424013837 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 757424013838 active site 757424013839 dimer interface [polypeptide binding]; other site 757424013840 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 757424013841 Ligand Binding Site [chemical binding]; other site 757424013842 Molecular Tunnel; other site 757424013843 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424013844 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 757424013845 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 757424013846 active site 757424013847 dimer interface [polypeptide binding]; other site 757424013848 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 757424013849 Ligand Binding Site [chemical binding]; other site 757424013850 Molecular Tunnel; other site 757424013851 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 757424013852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424013853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424013854 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 757424013855 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 757424013856 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 757424013857 NADP binding site [chemical binding]; other site 757424013858 active site 757424013859 putative substrate binding site [chemical binding]; other site 757424013860 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 757424013861 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 757424013862 NAD(P) binding site [chemical binding]; other site 757424013863 homodimer interface [polypeptide binding]; other site 757424013864 substrate binding site [chemical binding]; other site 757424013865 active site 757424013866 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 757424013867 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 757424013868 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 757424013869 active site 757424013870 homodimer interface [polypeptide binding]; other site 757424013871 Bacterial sugar transferase; Region: Bac_transf; pfam02397 757424013872 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 757424013873 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 757424013874 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 757424013875 NAD(P) binding site [chemical binding]; other site 757424013876 homodimer interface [polypeptide binding]; other site 757424013877 substrate binding site [chemical binding]; other site 757424013878 active site 757424013879 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 757424013880 ligand binding site [chemical binding]; other site 757424013881 malate:quinone oxidoreductase; Validated; Region: PRK05257 757424013882 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 757424013883 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 757424013884 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 757424013885 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 757424013886 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 757424013887 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 757424013888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424013889 putative substrate translocation pore; other site 757424013890 putative aldolase; Validated; Region: PRK08130 757424013891 intersubunit interface [polypeptide binding]; other site 757424013892 active site 757424013893 Zn2+ binding site [ion binding]; other site 757424013894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 757424013895 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 757424013896 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 757424013897 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424013898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424013899 DNA-binding site [nucleotide binding]; DNA binding site 757424013900 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424013901 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 757424013902 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 757424013903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424013904 putative substrate translocation pore; other site 757424013905 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 757424013906 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424013907 Uncharacterized conserved protein [Function unknown]; Region: COG3025 757424013908 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 757424013909 putative active site [active] 757424013910 putative metal binding residues [ion binding]; other site 757424013911 signature motif; other site 757424013912 putative triphosphate binding site [ion binding]; other site 757424013913 CHAD domain; Region: CHAD; pfam05235 757424013914 Predicted membrane protein [Function unknown]; Region: COG4267 757424013915 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 757424013916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424013917 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 757424013918 GAF domain; Region: GAF_3; pfam13492 757424013919 Predicted integral membrane protein [Function unknown]; Region: COG5616 757424013920 Tetratricopeptide repeat; Region: TPR_15; pfam13429 757424013921 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 757424013922 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 757424013923 putative active site [active] 757424013924 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424013925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424013926 DNA-binding site [nucleotide binding]; DNA binding site 757424013927 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424013928 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424013929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424013930 substrate binding pocket [chemical binding]; other site 757424013931 membrane-bound complex binding site; other site 757424013932 hinge residues; other site 757424013933 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424013934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424013935 dimer interface [polypeptide binding]; other site 757424013936 conserved gate region; other site 757424013937 putative PBP binding loops; other site 757424013938 ABC-ATPase subunit interface; other site 757424013939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424013940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424013941 Walker A/P-loop; other site 757424013942 ATP binding site [chemical binding]; other site 757424013943 Q-loop/lid; other site 757424013944 ABC transporter signature motif; other site 757424013945 Walker B; other site 757424013946 D-loop; other site 757424013947 H-loop/switch region; other site 757424013948 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 757424013949 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 757424013950 active site 757424013951 purine riboside binding site [chemical binding]; other site 757424013952 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424013953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424013954 DNA-binding site [nucleotide binding]; DNA binding site 757424013955 FCD domain; Region: FCD; pfam07729 757424013956 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 757424013957 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 757424013958 Na binding site [ion binding]; other site 757424013959 putative substrate binding site [chemical binding]; other site 757424013960 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 757424013961 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 757424013962 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 757424013963 active site 757424013964 catalytic site [active] 757424013965 tetramer interface [polypeptide binding]; other site 757424013966 Predicted membrane protein [Function unknown]; Region: COG3748 757424013967 Protein of unknown function (DUF989); Region: DUF989; pfam06181 757424013968 Cytochrome c; Region: Cytochrom_C; pfam00034 757424013969 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424013970 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424013971 trimer interface [polypeptide binding]; other site 757424013972 eyelet of channel; other site 757424013973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 757424013974 NMT1/THI5 like; Region: NMT1; pfam09084 757424013975 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 757424013976 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424013977 Walker A/P-loop; other site 757424013978 ATP binding site [chemical binding]; other site 757424013979 Q-loop/lid; other site 757424013980 ABC transporter signature motif; other site 757424013981 Walker B; other site 757424013982 D-loop; other site 757424013983 H-loop/switch region; other site 757424013984 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424013985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424013986 dimer interface [polypeptide binding]; other site 757424013987 conserved gate region; other site 757424013988 putative PBP binding loops; other site 757424013989 ABC-ATPase subunit interface; other site 757424013990 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 757424013991 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424013992 Walker A/P-loop; other site 757424013993 ATP binding site [chemical binding]; other site 757424013994 Q-loop/lid; other site 757424013995 ABC transporter signature motif; other site 757424013996 Walker B; other site 757424013997 D-loop; other site 757424013998 H-loop/switch region; other site 757424013999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424014000 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424014001 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 757424014002 TM-ABC transporter signature motif; other site 757424014003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424014004 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 757424014005 TM-ABC transporter signature motif; other site 757424014006 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 757424014007 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 757424014008 putative ligand binding site [chemical binding]; other site 757424014009 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 757424014010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424014011 non-specific DNA binding site [nucleotide binding]; other site 757424014012 salt bridge; other site 757424014013 sequence-specific DNA binding site [nucleotide binding]; other site 757424014014 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 757424014015 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 757424014016 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 757424014017 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 757424014018 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 757424014019 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 757424014020 Switch I; other site 757424014021 Switch II; other site 757424014022 cell division topological specificity factor MinE; Provisional; Region: PRK13989 757424014023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424014024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424014025 DNA binding site [nucleotide binding] 757424014026 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 757424014027 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 757424014028 tRNA; other site 757424014029 putative tRNA binding site [nucleotide binding]; other site 757424014030 putative NADP binding site [chemical binding]; other site 757424014031 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 757424014032 peptide chain release factor 1; Validated; Region: prfA; PRK00591 757424014033 This domain is found in peptide chain release factors; Region: PCRF; smart00937 757424014034 RF-1 domain; Region: RF-1; pfam00472 757424014035 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 757424014036 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 757424014037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424014038 S-adenosylmethionine binding site [chemical binding]; other site 757424014039 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 757424014040 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 757424014041 dimer interface [polypeptide binding]; other site 757424014042 PYR/PP interface [polypeptide binding]; other site 757424014043 TPP binding site [chemical binding]; other site 757424014044 substrate binding site [chemical binding]; other site 757424014045 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 757424014046 TPP-binding site [chemical binding]; other site 757424014047 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 757424014048 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 757424014049 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 757424014050 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 757424014051 cofactor binding site; other site 757424014052 metal binding site [ion binding]; metal-binding site 757424014053 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 757424014054 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 757424014055 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 757424014056 active site 757424014057 NTP binding site [chemical binding]; other site 757424014058 metal binding triad [ion binding]; metal-binding site 757424014059 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 757424014060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424014061 Zn2+ binding site [ion binding]; other site 757424014062 Mg2+ binding site [ion binding]; other site 757424014063 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 757424014064 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424014065 putative C-terminal domain interface [polypeptide binding]; other site 757424014066 putative GSH binding site (G-site) [chemical binding]; other site 757424014067 putative dimer interface [polypeptide binding]; other site 757424014068 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 757424014069 putative N-terminal domain interface [polypeptide binding]; other site 757424014070 putative dimer interface [polypeptide binding]; other site 757424014071 putative substrate binding pocket (H-site) [chemical binding]; other site 757424014072 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 757424014073 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 757424014074 putative NAD(P) binding site [chemical binding]; other site 757424014075 active site 757424014076 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 757424014077 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 757424014078 N-acetyl-D-glucosamine binding site [chemical binding]; other site 757424014079 catalytic residue [active] 757424014080 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 757424014081 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 757424014082 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 757424014083 FAD binding site [chemical binding]; other site 757424014084 Predicted membrane protein [Function unknown]; Region: COG1950 757424014085 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 757424014086 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 757424014087 homotetramer interface [polypeptide binding]; other site 757424014088 ligand binding site [chemical binding]; other site 757424014089 catalytic site [active] 757424014090 NAD binding site [chemical binding]; other site 757424014091 S-adenosylmethionine synthetase; Validated; Region: PRK05250 757424014092 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 757424014093 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 757424014094 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 757424014095 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 757424014096 putative acyl-acceptor binding pocket; other site 757424014097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 757424014098 putative acyl-acceptor binding pocket; other site 757424014099 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 757424014100 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 757424014101 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 757424014102 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424014103 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424014104 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424014105 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424014106 eyelet of channel; other site 757424014107 trimer interface [polypeptide binding]; other site 757424014108 Protein of unknown function, DUF484; Region: DUF484; cl17449 757424014109 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 757424014110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 757424014111 active site 757424014112 DNA binding site [nucleotide binding] 757424014113 Int/Topo IB signature motif; other site 757424014114 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 757424014115 metal binding site 2 [ion binding]; metal-binding site 757424014116 putative DNA binding helix; other site 757424014117 metal binding site 1 [ion binding]; metal-binding site 757424014118 structural Zn2+ binding site [ion binding]; other site 757424014119 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 757424014120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424014121 motif II; other site 757424014122 TraB family; Region: TraB; pfam01963 757424014123 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 757424014124 feedback inhibition sensing region; other site 757424014125 homohexameric interface [polypeptide binding]; other site 757424014126 nucleotide binding site [chemical binding]; other site 757424014127 N-acetyl-L-glutamate binding site [chemical binding]; other site 757424014128 Sporulation related domain; Region: SPOR; cl10051 757424014129 pantothenate kinase; Reviewed; Region: PRK13328 757424014130 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 757424014131 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 757424014132 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 757424014133 Predicted integral membrane protein [Function unknown]; Region: COG5652 757424014134 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 757424014135 dimer interface [polypeptide binding]; other site 757424014136 [2Fe-2S] cluster binding site [ion binding]; other site 757424014137 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 757424014138 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 757424014139 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 757424014140 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 757424014141 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 757424014142 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 757424014143 catalytic residue [active] 757424014144 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 757424014145 catalytic residues [active] 757424014146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424014147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 757424014148 peroxiredoxin; Region: AhpC; TIGR03137 757424014149 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 757424014150 dimer interface [polypeptide binding]; other site 757424014151 decamer (pentamer of dimers) interface [polypeptide binding]; other site 757424014152 catalytic triad [active] 757424014153 peroxidatic and resolving cysteines [active] 757424014154 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 757424014155 active site 757424014156 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 757424014157 active site 757424014158 substrate-binding site [chemical binding]; other site 757424014159 metal-binding site [ion binding] 757424014160 GTP binding site [chemical binding]; other site 757424014161 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 757424014162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 757424014163 dimerization interface [polypeptide binding]; other site 757424014164 NAD binding site [chemical binding]; other site 757424014165 ligand binding site [chemical binding]; other site 757424014166 catalytic site [active] 757424014167 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 757424014168 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 757424014169 active site 757424014170 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 757424014171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014172 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 757424014173 putative dimerization interface [polypeptide binding]; other site 757424014174 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 757424014175 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 757424014176 putative hydrophobic ligand binding site [chemical binding]; other site 757424014177 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 757424014178 Part of AAA domain; Region: AAA_19; pfam13245 757424014179 Family description; Region: UvrD_C_2; pfam13538 757424014180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 757424014181 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 757424014182 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 757424014183 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 757424014184 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 757424014185 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 757424014186 PGAP1-like protein; Region: PGAP1; pfam07819 757424014187 PAAR motif; Region: PAAR_motif; pfam05488 757424014188 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424014189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424014190 substrate binding pocket [chemical binding]; other site 757424014191 membrane-bound complex binding site; other site 757424014192 hinge residues; other site 757424014193 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 757424014194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424014195 dimer interface [polypeptide binding]; other site 757424014196 conserved gate region; other site 757424014197 putative PBP binding loops; other site 757424014198 ABC-ATPase subunit interface; other site 757424014199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424014200 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 757424014201 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 757424014202 active site 757424014203 DNA polymerase IV; Validated; Region: PRK02406 757424014204 DNA binding site [nucleotide binding] 757424014205 recombination associated protein; Reviewed; Region: rdgC; PRK00321 757424014206 Predicted dehydrogenase [General function prediction only]; Region: COG0579 757424014207 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424014208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 757424014209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 757424014210 elongation factor G; Reviewed; Region: PRK00007 757424014211 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 757424014212 G1 box; other site 757424014213 putative GEF interaction site [polypeptide binding]; other site 757424014214 GTP/Mg2+ binding site [chemical binding]; other site 757424014215 Switch I region; other site 757424014216 G2 box; other site 757424014217 G3 box; other site 757424014218 Switch II region; other site 757424014219 G4 box; other site 757424014220 G5 box; other site 757424014221 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 757424014222 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 757424014223 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 757424014224 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 757424014225 putative FMN binding site [chemical binding]; other site 757424014226 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 757424014227 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 757424014228 trmE is a tRNA modification GTPase; Region: trmE; cd04164 757424014229 G1 box; other site 757424014230 GTP/Mg2+ binding site [chemical binding]; other site 757424014231 Switch I region; other site 757424014232 G2 box; other site 757424014233 Switch II region; other site 757424014234 G3 box; other site 757424014235 G4 box; other site 757424014236 G5 box; other site 757424014237 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 757424014238 membrane protein insertase; Provisional; Region: PRK01318 757424014239 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 757424014240 Haemolytic domain; Region: Haemolytic; pfam01809 757424014241 Ribonuclease P; Region: Ribonuclease_P; cl00457 757424014242 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 757424014243 PrkA family serine protein kinase; Provisional; Region: PRK15455 757424014244 AAA ATPase domain; Region: AAA_16; pfam13191 757424014245 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 757424014246 hypothetical protein; Provisional; Region: PRK05325 757424014247 SpoVR family protein; Provisional; Region: PRK11767 757424014248 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 757424014249 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 757424014250 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 757424014251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 757424014253 putative substrate translocation pore; other site 757424014254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014256 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 757424014257 putative effector binding pocket; other site 757424014258 putative dimerization interface [polypeptide binding]; other site 757424014259 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 757424014260 short chain dehydrogenase; Provisional; Region: PRK06523 757424014261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424014262 NAD(P) binding site [chemical binding]; other site 757424014263 active site 757424014264 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 757424014265 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 757424014266 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 757424014267 substrate binding pocket [chemical binding]; other site 757424014268 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 757424014269 B12 binding site [chemical binding]; other site 757424014270 cobalt ligand [ion binding]; other site 757424014271 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 757424014272 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 757424014273 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 757424014274 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 757424014275 putative active site [active] 757424014276 substrate binding site [chemical binding]; other site 757424014277 putative cosubstrate binding site; other site 757424014278 catalytic site [active] 757424014279 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 757424014280 substrate binding site [chemical binding]; other site 757424014281 short chain dehydrogenase; Provisional; Region: PRK07024 757424014282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424014283 NAD(P) binding site [chemical binding]; other site 757424014284 active site 757424014285 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 757424014286 catalytic residues [active] 757424014287 hinge region; other site 757424014288 alpha helical domain; other site 757424014289 Sporulation related domain; Region: SPOR; pfam05036 757424014290 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 757424014291 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 757424014292 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 757424014293 active site 757424014294 HIGH motif; other site 757424014295 KMSK motif region; other site 757424014296 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 757424014297 tRNA binding surface [nucleotide binding]; other site 757424014298 anticodon binding site; other site 757424014299 primosome assembly protein PriA; Validated; Region: PRK05580 757424014300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424014301 ATP binding site [chemical binding]; other site 757424014302 putative Mg++ binding site [ion binding]; other site 757424014303 helicase superfamily c-terminal domain; Region: HELICc; smart00490 757424014304 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 757424014305 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 757424014306 substrate binding site [chemical binding]; other site 757424014307 active site 757424014308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424014309 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424014310 substrate binding pocket [chemical binding]; other site 757424014311 membrane-bound complex binding site; other site 757424014312 hinge residues; other site 757424014313 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 757424014314 CoA binding domain; Region: CoA_binding; cl17356 757424014315 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 757424014316 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 757424014317 gamma subunit interface [polypeptide binding]; other site 757424014318 epsilon subunit interface [polypeptide binding]; other site 757424014319 LBP interface [polypeptide binding]; other site 757424014320 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 757424014321 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 757424014322 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 757424014323 alpha subunit interaction interface [polypeptide binding]; other site 757424014324 Walker A motif; other site 757424014325 ATP binding site [chemical binding]; other site 757424014326 Walker B motif; other site 757424014327 inhibitor binding site; inhibition site 757424014328 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 757424014329 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 757424014330 core domain interface [polypeptide binding]; other site 757424014331 delta subunit interface [polypeptide binding]; other site 757424014332 epsilon subunit interface [polypeptide binding]; other site 757424014333 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 757424014334 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 757424014335 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 757424014336 beta subunit interaction interface [polypeptide binding]; other site 757424014337 Walker A motif; other site 757424014338 ATP binding site [chemical binding]; other site 757424014339 Walker B motif; other site 757424014340 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 757424014341 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 757424014342 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 757424014343 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 757424014344 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 757424014345 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 757424014346 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 757424014347 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 757424014348 ATP synthase I chain; Region: ATP_synt_I; cl09170 757424014349 HD domain; Region: HD_5; pfam13487 757424014350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 757424014351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424014352 DNA binding residues [nucleotide binding] 757424014353 dimerization interface [polypeptide binding]; other site 757424014354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424014355 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 757424014356 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 757424014357 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 757424014358 NADP binding site [chemical binding]; other site 757424014359 active site 757424014360 putative substrate binding site [chemical binding]; other site 757424014361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424014364 dimerization interface [polypeptide binding]; other site 757424014365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014366 D-galactonate transporter; Region: 2A0114; TIGR00893 757424014367 putative substrate translocation pore; other site 757424014368 amidase; Provisional; Region: PRK07486 757424014369 Amidase; Region: Amidase; cl11426 757424014370 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 757424014371 homotrimer interaction site [polypeptide binding]; other site 757424014372 putative active site [active] 757424014373 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424014374 hydroxyglutarate oxidase; Provisional; Region: PRK11728 757424014375 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 757424014376 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 757424014377 Sel1 repeat; Region: Sel1; cl02723 757424014378 Sel1 repeat; Region: Sel1; cl02723 757424014379 Sel1-like repeats; Region: SEL1; smart00671 757424014380 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 757424014381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424014382 N-terminal plug; other site 757424014383 ligand-binding site [chemical binding]; other site 757424014384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424014385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424014386 active site 757424014387 phosphorylation site [posttranslational modification] 757424014388 intermolecular recognition site; other site 757424014389 dimerization interface [polypeptide binding]; other site 757424014390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424014391 DNA binding site [nucleotide binding] 757424014392 HAMP domain; Region: HAMP; pfam00672 757424014393 dimerization interface [polypeptide binding]; other site 757424014394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424014395 dimer interface [polypeptide binding]; other site 757424014396 phosphorylation site [posttranslational modification] 757424014397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424014398 ATP binding site [chemical binding]; other site 757424014399 Mg2+ binding site [ion binding]; other site 757424014400 G-X-G motif; other site 757424014401 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 757424014402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424014403 Walker A/P-loop; other site 757424014404 ATP binding site [chemical binding]; other site 757424014405 Q-loop/lid; other site 757424014406 ABC transporter signature motif; other site 757424014407 Walker B; other site 757424014408 D-loop; other site 757424014409 H-loop/switch region; other site 757424014410 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 757424014411 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 757424014412 dimer interface [polypeptide binding]; other site 757424014413 putative PBP binding regions; other site 757424014414 ABC-ATPase subunit interface; other site 757424014415 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 757424014416 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 757424014417 putative ligand binding residues [chemical binding]; other site 757424014418 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 757424014419 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424014420 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 757424014421 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 757424014422 ligand binding site [chemical binding]; other site 757424014423 Predicted membrane protein [Function unknown]; Region: COG5393 757424014424 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 757424014425 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 757424014426 Peptidase C26; Region: Peptidase_C26; pfam07722 757424014427 catalytic triad [active] 757424014428 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424014429 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 757424014430 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 757424014431 TrkA-N domain; Region: TrkA_N; pfam02254 757424014432 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 757424014433 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 757424014434 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 757424014435 protein binding site [polypeptide binding]; other site 757424014436 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 757424014437 protein binding site [polypeptide binding]; other site 757424014438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424014439 dimer interface [polypeptide binding]; other site 757424014440 phosphorylation site [posttranslational modification] 757424014441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424014442 ATP binding site [chemical binding]; other site 757424014443 Mg2+ binding site [ion binding]; other site 757424014444 G-X-G motif; other site 757424014445 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 757424014446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424014447 active site 757424014448 phosphorylation site [posttranslational modification] 757424014449 intermolecular recognition site; other site 757424014450 dimerization interface [polypeptide binding]; other site 757424014451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424014452 DNA binding site [nucleotide binding] 757424014453 Uncharacterized conserved protein [Function unknown]; Region: COG1565 757424014454 short chain dehydrogenase; Provisional; Region: PRK09134 757424014455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424014456 NAD(P) binding site [chemical binding]; other site 757424014457 active site 757424014458 Dihydroneopterin aldolase; Region: FolB; smart00905 757424014459 active site 757424014460 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 757424014461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424014462 salt bridge; other site 757424014463 non-specific DNA binding site [nucleotide binding]; other site 757424014464 sequence-specific DNA binding site [nucleotide binding]; other site 757424014465 Uncharacterized conserved protein [Function unknown]; Region: COG1284 757424014466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 757424014467 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 757424014468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424014469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424014470 homodimer interface [polypeptide binding]; other site 757424014471 catalytic residue [active] 757424014472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424014475 dimerization interface [polypeptide binding]; other site 757424014476 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 757424014477 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 757424014478 Ligand Binding Site [chemical binding]; other site 757424014479 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 757424014480 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 757424014481 NAD binding site [chemical binding]; other site 757424014482 homotetramer interface [polypeptide binding]; other site 757424014483 homodimer interface [polypeptide binding]; other site 757424014484 substrate binding site [chemical binding]; other site 757424014485 active site 757424014486 UDP-glucose 4-epimerase; Region: PLN02240 757424014487 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 757424014488 NAD binding site [chemical binding]; other site 757424014489 homodimer interface [polypeptide binding]; other site 757424014490 active site 757424014491 substrate binding site [chemical binding]; other site 757424014492 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 757424014493 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 757424014494 NAD binding site [chemical binding]; other site 757424014495 substrate binding site [chemical binding]; other site 757424014496 homodimer interface [polypeptide binding]; other site 757424014497 active site 757424014498 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 757424014499 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 757424014500 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 757424014501 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 757424014502 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 757424014503 NADP binding site [chemical binding]; other site 757424014504 active site 757424014505 putative substrate binding site [chemical binding]; other site 757424014506 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 757424014507 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 757424014508 inhibitor-cofactor binding pocket; inhibition site 757424014509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424014510 catalytic residue [active] 757424014511 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 757424014512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 757424014513 active site 757424014514 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 757424014515 active site 757424014516 dimer interface [polypeptide binding]; other site 757424014517 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 757424014518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424014519 active site 757424014520 motif I; other site 757424014521 motif II; other site 757424014522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424014523 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 757424014524 Methyltransferase domain; Region: Methyltransf_23; pfam13489 757424014525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 757424014526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 757424014527 binding surface 757424014528 TPR repeat; Region: TPR_11; pfam13414 757424014529 TPR motif; other site 757424014530 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 757424014531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424014532 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 757424014533 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 757424014534 Substrate binding site; other site 757424014535 Mg++ binding site; other site 757424014536 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 757424014537 active site 757424014538 substrate binding site [chemical binding]; other site 757424014539 CoA binding site [chemical binding]; other site 757424014540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 757424014541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 757424014542 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 757424014543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424014544 putative DNA binding site [nucleotide binding]; other site 757424014545 putative Zn2+ binding site [ion binding]; other site 757424014546 AsnC family; Region: AsnC_trans_reg; pfam01037 757424014547 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 757424014548 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 757424014549 glutaminase active site [active] 757424014550 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 757424014551 dimer interface [polypeptide binding]; other site 757424014552 active site 757424014553 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 757424014554 dimer interface [polypeptide binding]; other site 757424014555 active site 757424014556 partial transposase 757424014557 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 757424014558 Superfamily II helicase [General function prediction only]; Region: COG1204 757424014559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424014560 ATP binding site [chemical binding]; other site 757424014561 putative Mg++ binding site [ion binding]; other site 757424014562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424014563 nucleotide binding region [chemical binding]; other site 757424014564 ATP-binding site [chemical binding]; other site 757424014565 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 757424014566 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 757424014567 Mechanosensitive ion channel; Region: MS_channel; pfam00924 757424014568 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 757424014569 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 757424014570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424014571 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 757424014572 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424014573 Outer membrane efflux protein; Region: OEP; pfam02321 757424014574 Outer membrane efflux protein; Region: OEP; pfam02321 757424014575 transcriptional regulator; Provisional; Region: PRK10632 757424014576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014577 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424014578 putative effector binding pocket; other site 757424014579 dimerization interface [polypeptide binding]; other site 757424014580 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 757424014581 oligomerisation interface [polypeptide binding]; other site 757424014582 mobile loop; other site 757424014583 roof hairpin; other site 757424014584 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 757424014585 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 757424014586 ring oligomerisation interface [polypeptide binding]; other site 757424014587 ATP/Mg binding site [chemical binding]; other site 757424014588 stacking interactions; other site 757424014589 hinge regions; other site 757424014590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 757424014591 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 757424014592 nucleotide binding site [chemical binding]; other site 757424014593 Domain of unknown function (DUF718); Region: DUF718; pfam05336 757424014594 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424014595 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424014596 TM-ABC transporter signature motif; other site 757424014597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424014598 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424014599 TM-ABC transporter signature motif; other site 757424014600 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 757424014601 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424014602 Walker A/P-loop; other site 757424014603 ATP binding site [chemical binding]; other site 757424014604 Q-loop/lid; other site 757424014605 ABC transporter signature motif; other site 757424014606 Walker B; other site 757424014607 D-loop; other site 757424014608 H-loop/switch region; other site 757424014609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424014610 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 757424014611 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 757424014612 ligand binding site [chemical binding]; other site 757424014613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 757424014614 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 757424014615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 757424014616 short chain dehydrogenase; Validated; Region: PRK08324 757424014617 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 757424014618 active site 757424014619 Zn2+ binding site [ion binding]; other site 757424014620 intersubunit interface [polypeptide binding]; other site 757424014621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424014622 NAD(P) binding site [chemical binding]; other site 757424014623 active site 757424014624 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 757424014625 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 757424014626 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 757424014627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424014628 active site 757424014629 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 757424014630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014631 putative substrate translocation pore; other site 757424014632 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 757424014633 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 757424014634 ligand binding site [chemical binding]; other site 757424014635 NAD binding site [chemical binding]; other site 757424014636 dimerization interface [polypeptide binding]; other site 757424014637 catalytic site [active] 757424014638 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 757424014639 hypothetical protein; Validated; Region: PRK06201 757424014640 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 757424014641 Strictosidine synthase; Region: Str_synth; pfam03088 757424014642 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 757424014643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014644 putative substrate translocation pore; other site 757424014645 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 757424014646 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 757424014647 active site 757424014648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 757424014651 dimerization interface [polypeptide binding]; other site 757424014652 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424014653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424014654 DNA-binding site [nucleotide binding]; DNA binding site 757424014655 FCD domain; Region: FCD; pfam07729 757424014656 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 757424014657 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 757424014658 hypothetical protein; Validated; Region: PRK06201 757424014659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014660 D-galactonate transporter; Region: 2A0114; TIGR00893 757424014661 putative substrate translocation pore; other site 757424014662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424014663 short chain dehydrogenase; Provisional; Region: PRK06500 757424014664 classical (c) SDRs; Region: SDR_c; cd05233 757424014665 NAD(P) binding site [chemical binding]; other site 757424014666 active site 757424014667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 757424014670 putative effector binding pocket; other site 757424014671 putative dimerization interface [polypeptide binding]; other site 757424014672 TraB family; Region: TraB; pfam01963 757424014673 Autotransporter beta-domain; Region: Autotransporter; pfam03797 757424014674 Uncharacterized conserved protein [Function unknown]; Region: COG1284 757424014675 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 757424014676 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 757424014677 Nitrate and nitrite sensing; Region: NIT; pfam08376 757424014678 ANTAR domain; Region: ANTAR; pfam03861 757424014679 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 757424014680 Amidase; Region: Amidase; cl11426 757424014681 urea carboxylase; Region: urea_carbox; TIGR02712 757424014682 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424014683 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424014684 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 757424014685 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 757424014686 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 757424014687 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 757424014688 carboxyltransferase (CT) interaction site; other site 757424014689 biotinylation site [posttranslational modification]; other site 757424014690 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 757424014691 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 757424014692 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 757424014693 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 757424014694 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 757424014695 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 757424014696 Walker A/P-loop; other site 757424014697 ATP binding site [chemical binding]; other site 757424014698 Q-loop/lid; other site 757424014699 ABC transporter signature motif; other site 757424014700 Walker B; other site 757424014701 D-loop; other site 757424014702 H-loop/switch region; other site 757424014703 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 757424014704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 757424014705 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 757424014706 NMT1/THI5 like; Region: NMT1; pfam09084 757424014707 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 757424014708 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 757424014709 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 757424014710 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424014711 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424014712 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424014713 Cytochrome c; Region: Cytochrom_C; pfam00034 757424014714 RNA polymerase sigma factor; Provisional; Region: PRK12528 757424014715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424014716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 757424014717 DNA binding residues [nucleotide binding] 757424014718 fec operon regulator FecR; Reviewed; Region: PRK09774 757424014719 FecR protein; Region: FecR; pfam04773 757424014720 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424014721 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 757424014722 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424014723 N-terminal plug; other site 757424014724 ligand-binding site [chemical binding]; other site 757424014725 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 757424014726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 757424014727 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 757424014728 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 757424014729 LysR family transcriptional regulator; Provisional; Region: PRK14997 757424014730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014731 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 757424014732 putative effector binding pocket; other site 757424014733 putative dimerization interface [polypeptide binding]; other site 757424014734 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 757424014735 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424014736 N-terminal plug; other site 757424014737 ligand-binding site [chemical binding]; other site 757424014738 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 757424014739 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 757424014740 putative NAD(P) binding site [chemical binding]; other site 757424014741 putative substrate binding site [chemical binding]; other site 757424014742 catalytic Zn binding site [ion binding]; other site 757424014743 structural Zn binding site [ion binding]; other site 757424014744 dimer interface [polypeptide binding]; other site 757424014745 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 757424014746 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 757424014747 active site 757424014748 catalytic residues [active] 757424014749 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 757424014750 putative dimerization interface [polypeptide binding]; other site 757424014751 Transcriptional regulators [Transcription]; Region: PurR; COG1609 757424014752 putative ligand binding site [chemical binding]; other site 757424014753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 757424014754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424014755 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 757424014756 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 757424014757 putative ligand binding site [chemical binding]; other site 757424014758 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 757424014759 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 757424014760 Walker A/P-loop; other site 757424014761 ATP binding site [chemical binding]; other site 757424014762 Q-loop/lid; other site 757424014763 ABC transporter signature motif; other site 757424014764 Walker B; other site 757424014765 D-loop; other site 757424014766 H-loop/switch region; other site 757424014767 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 757424014768 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 757424014769 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 757424014770 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424014771 TM-ABC transporter signature motif; other site 757424014772 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 757424014773 classical (c) SDRs; Region: SDR_c; cd05233 757424014774 NAD(P) binding site [chemical binding]; other site 757424014775 active site 757424014776 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 757424014777 Amidohydrolase; Region: Amidohydro_2; pfam04909 757424014778 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 757424014779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424014780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424014781 metal binding site [ion binding]; metal-binding site 757424014782 active site 757424014783 I-site; other site 757424014784 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 757424014785 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 757424014786 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 757424014787 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 757424014788 putative active site [active] 757424014789 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 757424014790 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 757424014791 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 757424014792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 757424014793 motif II; other site 757424014794 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 757424014795 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 757424014796 dimer interface [polypeptide binding]; other site 757424014797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424014798 ligand binding site [chemical binding]; other site 757424014799 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 757424014800 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 757424014801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424014802 active site 757424014803 phosphorylation site [posttranslational modification] 757424014804 intermolecular recognition site; other site 757424014805 dimerization interface [polypeptide binding]; other site 757424014806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424014807 DNA binding residues [nucleotide binding] 757424014808 dimerization interface [polypeptide binding]; other site 757424014809 Secretin and TonB N terminus short domain; Region: STN; smart00965 757424014810 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 757424014811 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 757424014812 N-terminal plug; other site 757424014813 ligand-binding site [chemical binding]; other site 757424014814 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 757424014815 FecR protein; Region: FecR; pfam04773 757424014816 RNA polymerase sigma factor; Provisional; Region: PRK12528 757424014817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 757424014818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 757424014819 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424014820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424014821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424014822 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 757424014823 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 757424014824 dimerization interface [polypeptide binding]; other site 757424014825 DPS ferroxidase diiron center [ion binding]; other site 757424014826 ion pore; other site 757424014827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 757424014828 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 757424014829 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 757424014830 Predicted membrane protein [Function unknown]; Region: COG2259 757424014831 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 757424014832 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 757424014833 active site 757424014834 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 757424014835 Isochorismatase family; Region: Isochorismatase; pfam00857 757424014836 catalytic triad [active] 757424014837 dimer interface [polypeptide binding]; other site 757424014838 conserved cis-peptide bond; other site 757424014839 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 757424014840 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 757424014841 Response regulator receiver domain; Region: Response_reg; pfam00072 757424014842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 757424014843 active site 757424014844 phosphorylation site [posttranslational modification] 757424014845 intermolecular recognition site; other site 757424014846 dimerization interface [polypeptide binding]; other site 757424014847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424014848 PAS fold; Region: PAS_3; pfam08447 757424014849 putative active site [active] 757424014850 heme pocket [chemical binding]; other site 757424014851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424014852 dimer interface [polypeptide binding]; other site 757424014853 phosphorylation site [posttranslational modification] 757424014854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424014855 ATP binding site [chemical binding]; other site 757424014856 G-X-G motif; other site 757424014857 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 757424014858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424014859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424014860 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 757424014861 Predicted membrane protein [Function unknown]; Region: COG4125 757424014862 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 757424014863 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 757424014864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424014865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424014866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424014867 dimerization interface [polypeptide binding]; other site 757424014868 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 757424014869 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 757424014870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 757424014871 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 757424014872 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 757424014873 trimer interface [polypeptide binding]; other site 757424014874 eyelet of channel; other site 757424014875 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 757424014876 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 757424014877 Walker A/P-loop; other site 757424014878 ATP binding site [chemical binding]; other site 757424014879 Q-loop/lid; other site 757424014880 ABC transporter signature motif; other site 757424014881 Walker B; other site 757424014882 D-loop; other site 757424014883 H-loop/switch region; other site 757424014884 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 757424014885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424014886 dimer interface [polypeptide binding]; other site 757424014887 conserved gate region; other site 757424014888 ABC-ATPase subunit interface; other site 757424014889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424014890 dimer interface [polypeptide binding]; other site 757424014891 conserved gate region; other site 757424014892 putative PBP binding loops; other site 757424014893 ABC-ATPase subunit interface; other site 757424014894 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 757424014895 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 757424014896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 757424014897 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 757424014898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424014899 active site 757424014900 phosphorylation site [posttranslational modification] 757424014901 intermolecular recognition site; other site 757424014902 dimerization interface [polypeptide binding]; other site 757424014903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424014904 DNA binding site [nucleotide binding] 757424014905 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424014906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424014907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 757424014908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424014909 dimer interface [polypeptide binding]; other site 757424014910 phosphorylation site [posttranslational modification] 757424014911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424014912 ATP binding site [chemical binding]; other site 757424014913 Mg2+ binding site [ion binding]; other site 757424014914 G-X-G motif; other site 757424014915 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424014916 HAMP domain; Region: HAMP; pfam00672 757424014917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424014918 dimer interface [polypeptide binding]; other site 757424014919 putative CheW interface [polypeptide binding]; other site 757424014920 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 757424014921 active sites [active] 757424014922 tetramer interface [polypeptide binding]; other site 757424014923 allantoate amidohydrolase; Reviewed; Region: PRK12890 757424014924 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 757424014925 active site 757424014926 metal binding site [ion binding]; metal-binding site 757424014927 dimer interface [polypeptide binding]; other site 757424014928 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 757424014929 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 757424014930 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424014931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424014932 DNA-binding site [nucleotide binding]; DNA binding site 757424014933 FCD domain; Region: FCD; pfam07729 757424014934 Cache domain; Region: Cache_1; pfam02743 757424014935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424014936 dimerization interface [polypeptide binding]; other site 757424014937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424014938 dimer interface [polypeptide binding]; other site 757424014939 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424014940 putative CheW interface [polypeptide binding]; other site 757424014941 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 757424014942 heme binding pocket [chemical binding]; other site 757424014943 heme ligand [chemical binding]; other site 757424014944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 757424014945 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 757424014946 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 757424014947 active site 757424014948 catalytic tetrad [active] 757424014949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424014950 dimer interface [polypeptide binding]; other site 757424014951 phosphorylation site [posttranslational modification] 757424014952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424014953 ATP binding site [chemical binding]; other site 757424014954 Mg2+ binding site [ion binding]; other site 757424014955 G-X-G motif; other site 757424014956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424014957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424014958 active site 757424014959 phosphorylation site [posttranslational modification] 757424014960 intermolecular recognition site; other site 757424014961 dimerization interface [polypeptide binding]; other site 757424014962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424014963 DNA binding site [nucleotide binding] 757424014964 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424014965 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424014966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424014967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424014968 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 757424014969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424014970 dimer interface [polypeptide binding]; other site 757424014971 conserved gate region; other site 757424014972 putative PBP binding loops; other site 757424014973 ABC-ATPase subunit interface; other site 757424014974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 757424014975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424014976 dimer interface [polypeptide binding]; other site 757424014977 conserved gate region; other site 757424014978 putative PBP binding loops; other site 757424014979 ABC-ATPase subunit interface; other site 757424014980 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 757424014981 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 757424014982 Walker A/P-loop; other site 757424014983 ATP binding site [chemical binding]; other site 757424014984 Q-loop/lid; other site 757424014985 ABC transporter signature motif; other site 757424014986 Walker B; other site 757424014987 D-loop; other site 757424014988 H-loop/switch region; other site 757424014989 TOBE domain; Region: TOBE_2; pfam08402 757424014990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 757424014991 nucleotide binding site [chemical binding]; other site 757424014992 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 757424014993 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 757424014994 active site 757424014995 dimer interface [polypeptide binding]; other site 757424014996 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 757424014997 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 757424014998 dimer interface [polypeptide binding]; other site 757424014999 active site 757424015000 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 757424015001 dimer interface [polypeptide binding]; other site 757424015002 active site 757424015003 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 757424015004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015005 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 757424015006 putative dimerization interface [polypeptide binding]; other site 757424015007 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 757424015008 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 757424015009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424015010 ATP binding site [chemical binding]; other site 757424015011 putative Mg++ binding site [ion binding]; other site 757424015012 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 757424015013 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 757424015014 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 757424015015 HsdM N-terminal domain; Region: HsdM_N; pfam12161 757424015016 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 757424015017 Methyltransferase domain; Region: Methyltransf_26; pfam13659 757424015018 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 757424015019 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 757424015020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 757424015021 Coenzyme A binding pocket [chemical binding]; other site 757424015022 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 757424015023 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 757424015024 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424015025 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424015026 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 757424015027 Cytochrome c; Region: Cytochrom_C; pfam00034 757424015028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 757424015029 dimerization interface [polypeptide binding]; other site 757424015030 putative DNA binding site [nucleotide binding]; other site 757424015031 putative Zn2+ binding site [ion binding]; other site 757424015032 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 757424015033 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 757424015034 active site 757424015035 FMN binding site [chemical binding]; other site 757424015036 substrate binding site [chemical binding]; other site 757424015037 homotetramer interface [polypeptide binding]; other site 757424015038 catalytic residue [active] 757424015039 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 757424015040 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 757424015041 putative C-terminal domain interface [polypeptide binding]; other site 757424015042 putative GSH binding site (G-site) [chemical binding]; other site 757424015043 putative dimer interface [polypeptide binding]; other site 757424015044 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 757424015045 putative N-terminal domain interface [polypeptide binding]; other site 757424015046 putative dimer interface [polypeptide binding]; other site 757424015047 putative substrate binding pocket (H-site) [chemical binding]; other site 757424015048 EamA-like transporter family; Region: EamA; pfam00892 757424015049 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 757424015050 EamA-like transporter family; Region: EamA; pfam00892 757424015051 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 757424015052 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 757424015053 cell density-dependent motility repressor; Provisional; Region: PRK10082 757424015054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015055 LysR substrate binding domain; Region: LysR_substrate; pfam03466 757424015056 dimerization interface [polypeptide binding]; other site 757424015057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424015058 S-adenosylmethionine binding site [chemical binding]; other site 757424015059 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 757424015060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 757424015061 active site 757424015062 nucleotide binding site [chemical binding]; other site 757424015063 HIGH motif; other site 757424015064 KMSKS motif; other site 757424015065 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 757424015066 nudix motif; other site 757424015067 NAD synthetase; Provisional; Region: PRK13981 757424015068 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 757424015069 multimer interface [polypeptide binding]; other site 757424015070 active site 757424015071 catalytic triad [active] 757424015072 protein interface 1 [polypeptide binding]; other site 757424015073 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 757424015074 homodimer interface [polypeptide binding]; other site 757424015075 NAD binding pocket [chemical binding]; other site 757424015076 ATP binding pocket [chemical binding]; other site 757424015077 Mg binding site [ion binding]; other site 757424015078 active-site loop [active] 757424015079 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 757424015080 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 757424015081 active site 757424015082 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 757424015083 catalytic triad [active] 757424015084 conserved cis-peptide bond; other site 757424015085 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 757424015086 nudix motif; other site 757424015087 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 757424015088 Low affinity iron permease; Region: Iron_permease; pfam04120 757424015089 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 757424015090 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 757424015091 NAD(P) binding site [chemical binding]; other site 757424015092 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 757424015093 active site 757424015094 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 757424015095 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 757424015096 NAD(P) binding site [chemical binding]; other site 757424015097 catalytic residues [active] 757424015098 Activator of aromatic catabolism; Region: XylR_N; pfam06505 757424015099 V4R domain; Region: V4R; pfam02830 757424015100 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 757424015101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424015102 Walker A motif; other site 757424015103 ATP binding site [chemical binding]; other site 757424015104 Walker B motif; other site 757424015105 arginine finger; other site 757424015106 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 757424015107 benzoate transport; Region: 2A0115; TIGR00895 757424015108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015109 putative substrate translocation pore; other site 757424015110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015111 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 757424015112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 757424015113 ATP binding site [chemical binding]; other site 757424015114 putative Mg++ binding site [ion binding]; other site 757424015115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 757424015116 nucleotide binding region [chemical binding]; other site 757424015117 ATP-binding site [chemical binding]; other site 757424015118 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 757424015119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424015120 substrate binding pocket [chemical binding]; other site 757424015121 membrane-bound complex binding site; other site 757424015122 hinge residues; other site 757424015123 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 757424015124 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 757424015125 active site 757424015126 non-prolyl cis peptide bond; other site 757424015127 Isochorismatase family; Region: Isochorismatase; pfam00857 757424015128 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 757424015129 catalytic triad [active] 757424015130 conserved cis-peptide bond; other site 757424015131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 757424015132 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 757424015133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 757424015134 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 757424015135 putative hydrophobic ligand binding site [chemical binding]; other site 757424015136 Sulfatase; Region: Sulfatase; pfam00884 757424015137 CHASE3 domain; Region: CHASE3; cl05000 757424015138 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424015139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015140 dimerization interface [polypeptide binding]; other site 757424015141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424015142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015143 dimer interface [polypeptide binding]; other site 757424015144 putative CheW interface [polypeptide binding]; other site 757424015145 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 757424015146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 757424015147 active site 757424015148 benzoate transport; Region: 2A0115; TIGR00895 757424015149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015150 putative substrate translocation pore; other site 757424015151 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 757424015152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424015153 DNA-binding site [nucleotide binding]; DNA binding site 757424015154 UTRA domain; Region: UTRA; pfam07702 757424015155 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 757424015156 toxin interface [polypeptide binding]; other site 757424015157 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 757424015158 Zn binding site [ion binding]; other site 757424015159 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 757424015160 peptide binding site [polypeptide binding]; other site 757424015161 glutathione S-transferase; Provisional; Region: PRK15113 757424015162 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 757424015163 C-terminal domain interface [polypeptide binding]; other site 757424015164 GSH binding site (G-site) [chemical binding]; other site 757424015165 dimer interface [polypeptide binding]; other site 757424015166 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 757424015167 putative dimer interface [polypeptide binding]; other site 757424015168 N-terminal domain interface [polypeptide binding]; other site 757424015169 putative substrate binding pocket (H-site) [chemical binding]; other site 757424015170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015171 D-galactonate transporter; Region: 2A0114; TIGR00893 757424015172 putative substrate translocation pore; other site 757424015173 Transcriptional regulators [Transcription]; Region: FadR; COG2186 757424015174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424015175 DNA-binding site [nucleotide binding]; DNA binding site 757424015176 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 757424015177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 757424015178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 757424015179 substrate binding pocket [chemical binding]; other site 757424015180 membrane-bound complex binding site; other site 757424015181 hinge residues; other site 757424015182 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 757424015183 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 757424015184 Walker A/P-loop; other site 757424015185 ATP binding site [chemical binding]; other site 757424015186 Q-loop/lid; other site 757424015187 ABC transporter signature motif; other site 757424015188 Walker B; other site 757424015189 D-loop; other site 757424015190 H-loop/switch region; other site 757424015191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424015192 dimer interface [polypeptide binding]; other site 757424015193 conserved gate region; other site 757424015194 putative PBP binding loops; other site 757424015195 ABC-ATPase subunit interface; other site 757424015196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424015197 dimer interface [polypeptide binding]; other site 757424015198 conserved gate region; other site 757424015199 ABC-ATPase subunit interface; other site 757424015200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424015201 NADH(P)-binding; Region: NAD_binding_10; pfam13460 757424015202 NAD(P) binding site [chemical binding]; other site 757424015203 active site 757424015204 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 757424015205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015206 dimer interface [polypeptide binding]; other site 757424015207 putative CheW interface [polypeptide binding]; other site 757424015208 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 757424015209 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 757424015210 Protein export membrane protein; Region: SecD_SecF; cl14618 757424015211 Protein export membrane protein; Region: SecD_SecF; cl14618 757424015212 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 757424015213 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424015214 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424015215 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 757424015216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015217 dimerization interface [polypeptide binding]; other site 757424015218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424015219 dimer interface [polypeptide binding]; other site 757424015220 phosphorylation site [posttranslational modification] 757424015221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424015222 ATP binding site [chemical binding]; other site 757424015223 Mg2+ binding site [ion binding]; other site 757424015224 G-X-G motif; other site 757424015225 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 757424015226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424015227 active site 757424015228 phosphorylation site [posttranslational modification] 757424015229 intermolecular recognition site; other site 757424015230 dimerization interface [polypeptide binding]; other site 757424015231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424015232 DNA binding site [nucleotide binding] 757424015233 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424015234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015235 dimerization interface [polypeptide binding]; other site 757424015236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015237 dimer interface [polypeptide binding]; other site 757424015238 putative CheW interface [polypeptide binding]; other site 757424015239 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 757424015240 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 757424015241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 757424015242 HlyD family secretion protein; Region: HlyD_3; pfam13437 757424015243 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 757424015244 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 757424015245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 757424015246 Cytochrome c2 [Energy production and conversion]; Region: COG3474 757424015247 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 757424015248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 757424015249 non-specific DNA binding site [nucleotide binding]; other site 757424015250 salt bridge; other site 757424015251 sequence-specific DNA binding site [nucleotide binding]; other site 757424015252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 757424015253 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 757424015254 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 757424015255 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 757424015256 conserved cys residue [active] 757424015257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 757424015258 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 757424015259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424015260 NAD(P) binding site [chemical binding]; other site 757424015261 active site 757424015262 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 757424015263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 757424015264 NAD(P) binding site [chemical binding]; other site 757424015265 active site 757424015266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015267 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 757424015268 putative substrate translocation pore; other site 757424015269 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 757424015270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424015271 active site 757424015272 phosphorylation site [posttranslational modification] 757424015273 intermolecular recognition site; other site 757424015274 dimerization interface [polypeptide binding]; other site 757424015275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424015276 Walker A motif; other site 757424015277 ATP binding site [chemical binding]; other site 757424015278 Walker B motif; other site 757424015279 arginine finger; other site 757424015280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424015281 dimer interface [polypeptide binding]; other site 757424015282 phosphorylation site [posttranslational modification] 757424015283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424015284 ATP binding site [chemical binding]; other site 757424015285 G-X-G motif; other site 757424015286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424015287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424015288 metal binding site [ion binding]; metal-binding site 757424015289 active site 757424015290 I-site; other site 757424015291 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 757424015292 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 757424015293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424015294 PAS domain; Region: PAS_9; pfam13426 757424015295 putative active site [active] 757424015296 heme pocket [chemical binding]; other site 757424015297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 757424015298 DNA binding residues [nucleotide binding] 757424015299 dimerization interface [polypeptide binding]; other site 757424015300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424015301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015302 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 757424015303 putative effector binding pocket; other site 757424015304 dimerization interface [polypeptide binding]; other site 757424015305 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 757424015306 NADH(P)-binding; Region: NAD_binding_10; pfam13460 757424015307 NAD binding site [chemical binding]; other site 757424015308 putative active site [active] 757424015309 substrate binding site [chemical binding]; other site 757424015310 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 757424015311 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 757424015312 catalytic residues [active] 757424015313 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424015314 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015315 dimer interface [polypeptide binding]; other site 757424015316 putative CheW interface [polypeptide binding]; other site 757424015317 CHASE3 domain; Region: CHASE3; pfam05227 757424015318 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 757424015319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015320 dimer interface [polypeptide binding]; other site 757424015321 putative CheW interface [polypeptide binding]; other site 757424015322 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 757424015323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 757424015324 motif II; other site 757424015325 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 757424015326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424015327 DNA-binding site [nucleotide binding]; DNA binding site 757424015328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424015329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424015330 homodimer interface [polypeptide binding]; other site 757424015331 catalytic residue [active] 757424015332 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 757424015333 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 757424015334 inhibitor-cofactor binding pocket; inhibition site 757424015335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424015336 catalytic residue [active] 757424015337 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 757424015338 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 757424015339 tetrameric interface [polypeptide binding]; other site 757424015340 NAD binding site [chemical binding]; other site 757424015341 catalytic residues [active] 757424015342 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424015343 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 757424015344 putative ligand binding site [chemical binding]; other site 757424015345 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424015346 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424015347 TM-ABC transporter signature motif; other site 757424015348 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424015349 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424015350 TM-ABC transporter signature motif; other site 757424015351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424015352 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424015353 Walker A/P-loop; other site 757424015354 ATP binding site [chemical binding]; other site 757424015355 Q-loop/lid; other site 757424015356 ABC transporter signature motif; other site 757424015357 Walker B; other site 757424015358 D-loop; other site 757424015359 H-loop/switch region; other site 757424015360 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424015361 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424015362 Walker A/P-loop; other site 757424015363 ATP binding site [chemical binding]; other site 757424015364 Q-loop/lid; other site 757424015365 ABC transporter signature motif; other site 757424015366 Walker B; other site 757424015367 D-loop; other site 757424015368 H-loop/switch region; other site 757424015369 allantoate amidohydrolase; Reviewed; Region: PRK12893 757424015370 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 757424015371 active site 757424015372 metal binding site [ion binding]; metal-binding site 757424015373 dimer interface [polypeptide binding]; other site 757424015374 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 757424015375 Uncharacterized conserved protein [Function unknown]; Region: COG5476 757424015376 MlrC C-terminus; Region: MlrC_C; pfam07171 757424015377 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424015378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015379 dimerization interface [polypeptide binding]; other site 757424015380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015381 dimer interface [polypeptide binding]; other site 757424015382 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 757424015383 putative CheW interface [polypeptide binding]; other site 757424015384 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 757424015385 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 757424015386 active site 757424015387 iron coordination sites [ion binding]; other site 757424015388 substrate binding pocket [chemical binding]; other site 757424015389 Cupin-like domain; Region: Cupin_8; pfam13621 757424015390 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 757424015391 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 757424015392 GatB domain; Region: GatB_Yqey; smart00845 757424015393 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 757424015394 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 757424015395 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 757424015396 rod shape-determining protein MreB; Provisional; Region: PRK13927 757424015397 MreB and similar proteins; Region: MreB_like; cd10225 757424015398 nucleotide binding site [chemical binding]; other site 757424015399 Mg binding site [ion binding]; other site 757424015400 putative protofilament interaction site [polypeptide binding]; other site 757424015401 RodZ interaction site [polypeptide binding]; other site 757424015402 rod shape-determining protein MreC; Provisional; Region: PRK13922 757424015403 rod shape-determining protein MreC; Region: MreC; pfam04085 757424015404 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 757424015405 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 757424015406 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 757424015407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 757424015408 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 757424015409 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 757424015410 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 757424015411 Sporulation related domain; Region: SPOR; pfam05036 757424015412 Predicted methyltransferases [General function prediction only]; Region: COG0313 757424015413 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 757424015414 putative SAM binding site [chemical binding]; other site 757424015415 putative homodimer interface [polypeptide binding]; other site 757424015416 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 757424015417 hypothetical protein; Reviewed; Region: PRK12497 757424015418 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 757424015419 dimer interface [polypeptide binding]; other site 757424015420 active site 757424015421 BON domain; Region: BON; pfam04972 757424015422 BON domain; Region: BON; pfam04972 757424015423 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 757424015424 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 757424015425 catalytic residues [active] 757424015426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 757424015427 active site 757424015428 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 757424015429 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 757424015430 putative active site [active] 757424015431 putative catalytic site [active] 757424015432 putative DNA binding site [nucleotide binding]; other site 757424015433 putative phosphate binding site [ion binding]; other site 757424015434 metal binding site A [ion binding]; metal-binding site 757424015435 putative AP binding site [nucleotide binding]; other site 757424015436 putative metal binding site B [ion binding]; other site 757424015437 DNA topoisomerase III; Validated; Region: PRK08173 757424015438 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 757424015439 active site 757424015440 putative interdomain interaction site [polypeptide binding]; other site 757424015441 putative metal-binding site [ion binding]; other site 757424015442 putative nucleotide binding site [chemical binding]; other site 757424015443 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 757424015444 domain I; other site 757424015445 DNA binding groove [nucleotide binding] 757424015446 phosphate binding site [ion binding]; other site 757424015447 domain II; other site 757424015448 domain III; other site 757424015449 nucleotide binding site [chemical binding]; other site 757424015450 catalytic site [active] 757424015451 domain IV; other site 757424015452 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 757424015453 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 757424015454 Protein of unknown function (DUF494); Region: DUF494; pfam04361 757424015455 DNA protecting protein DprA; Region: dprA; TIGR00732 757424015456 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 757424015457 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 757424015458 active site 757424015459 catalytic residues [active] 757424015460 metal binding site [ion binding]; metal-binding site 757424015461 L-aspartate dehydrogenase; Reviewed; Region: PRK13304 757424015462 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 757424015463 Domain of unknown function DUF108; Region: DUF108; pfam01958 757424015464 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424015465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015466 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424015467 dimerization interface [polypeptide binding]; other site 757424015468 substrate binding pocket [chemical binding]; other site 757424015469 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 757424015470 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 757424015471 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 757424015472 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 757424015473 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 757424015474 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 757424015475 DNA binding residues [nucleotide binding] 757424015476 putative dimer interface [polypeptide binding]; other site 757424015477 isovaleryl-CoA dehydrogenase; Region: PLN02519 757424015478 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 757424015479 substrate binding site [chemical binding]; other site 757424015480 FAD binding site [chemical binding]; other site 757424015481 catalytic base [active] 757424015482 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 757424015483 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 757424015484 putative catalytic residue [active] 757424015485 hypothetical protein; Provisional; Region: PRK01842 757424015486 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 757424015487 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 757424015488 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 757424015489 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 757424015490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 757424015491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 757424015492 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 757424015493 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 757424015494 carboxyltransferase (CT) interaction site; other site 757424015495 biotinylation site [posttranslational modification]; other site 757424015496 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 757424015497 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 757424015498 putative deacylase active site [active] 757424015499 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 757424015500 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 757424015501 active site 757424015502 catalytic residues [active] 757424015503 metal binding site [ion binding]; metal-binding site 757424015504 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 757424015505 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 757424015506 FMN binding site [chemical binding]; other site 757424015507 substrate binding site [chemical binding]; other site 757424015508 putative catalytic residue [active] 757424015509 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 757424015510 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 757424015511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424015512 Zn2+ binding site [ion binding]; other site 757424015513 Mg2+ binding site [ion binding]; other site 757424015514 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 757424015515 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 757424015516 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 757424015517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 757424015518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424015519 homodimer interface [polypeptide binding]; other site 757424015520 catalytic residue [active] 757424015521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 757424015522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 757424015523 ligand binding site [chemical binding]; other site 757424015524 flexible hinge region; other site 757424015525 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 757424015526 non-specific DNA interactions [nucleotide binding]; other site 757424015527 DNA binding site [nucleotide binding] 757424015528 sequence specific DNA binding site [nucleotide binding]; other site 757424015529 putative cAMP binding site [chemical binding]; other site 757424015530 acyl-CoA synthetase; Validated; Region: PRK08162 757424015531 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 757424015532 acyl-activating enzyme (AAE) consensus motif; other site 757424015533 putative active site [active] 757424015534 AMP binding site [chemical binding]; other site 757424015535 putative CoA binding site [chemical binding]; other site 757424015536 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 757424015537 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 757424015538 Sodium Bile acid symporter family; Region: SBF; pfam01758 757424015539 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 757424015540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 757424015541 Walker A/P-loop; other site 757424015542 ATP binding site [chemical binding]; other site 757424015543 Q-loop/lid; other site 757424015544 ABC transporter signature motif; other site 757424015545 Walker B; other site 757424015546 D-loop; other site 757424015547 H-loop/switch region; other site 757424015548 ABC transporter; Region: ABC_tran_2; pfam12848 757424015549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 757424015550 Predicted permeases [General function prediction only]; Region: RarD; COG2962 757424015551 EamA-like transporter family; Region: EamA; pfam00892 757424015552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015553 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 757424015554 putative substrate translocation pore; other site 757424015555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 757424015556 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 757424015557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015558 dimerization interface [polypeptide binding]; other site 757424015559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424015560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424015561 metal binding site [ion binding]; metal-binding site 757424015562 active site 757424015563 I-site; other site 757424015564 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 757424015565 dinuclear metal binding motif [ion binding]; other site 757424015566 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424015567 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 757424015568 putative ligand binding site [chemical binding]; other site 757424015569 HEAT repeats; Region: HEAT_2; pfam13646 757424015570 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424015571 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424015572 TM-ABC transporter signature motif; other site 757424015573 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424015574 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424015575 TM-ABC transporter signature motif; other site 757424015576 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 757424015577 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424015578 Walker A/P-loop; other site 757424015579 ATP binding site [chemical binding]; other site 757424015580 Q-loop/lid; other site 757424015581 ABC transporter signature motif; other site 757424015582 Walker B; other site 757424015583 D-loop; other site 757424015584 H-loop/switch region; other site 757424015585 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 757424015586 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424015587 Walker A/P-loop; other site 757424015588 ATP binding site [chemical binding]; other site 757424015589 Q-loop/lid; other site 757424015590 ABC transporter signature motif; other site 757424015591 Walker B; other site 757424015592 D-loop; other site 757424015593 H-loop/switch region; other site 757424015594 UreD urease accessory protein; Region: UreD; pfam01774 757424015595 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 757424015596 alpha-gamma subunit interface [polypeptide binding]; other site 757424015597 beta-gamma subunit interface [polypeptide binding]; other site 757424015598 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 757424015599 gamma-beta subunit interface [polypeptide binding]; other site 757424015600 alpha-beta subunit interface [polypeptide binding]; other site 757424015601 urease subunit alpha; Reviewed; Region: ureC; PRK13207 757424015602 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 757424015603 subunit interactions [polypeptide binding]; other site 757424015604 active site 757424015605 flap region; other site 757424015606 UreE urease accessory protein, N-terminal domain; Region: UreE_N; smart00988 757424015607 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 757424015608 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 757424015609 UreF; Region: UreF; pfam01730 757424015610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424015611 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 757424015612 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 757424015613 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 757424015614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424015615 dimer interface [polypeptide binding]; other site 757424015616 conserved gate region; other site 757424015617 ABC-ATPase subunit interface; other site 757424015618 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 757424015619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 757424015620 dimer interface [polypeptide binding]; other site 757424015621 conserved gate region; other site 757424015622 ABC-ATPase subunit interface; other site 757424015623 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 757424015624 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 757424015625 Walker A/P-loop; other site 757424015626 ATP binding site [chemical binding]; other site 757424015627 Q-loop/lid; other site 757424015628 ABC transporter signature motif; other site 757424015629 Walker B; other site 757424015630 D-loop; other site 757424015631 H-loop/switch region; other site 757424015632 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 757424015633 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 757424015634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 757424015635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424015636 active site 757424015637 phosphorylation site [posttranslational modification] 757424015638 intermolecular recognition site; other site 757424015639 dimerization interface [polypeptide binding]; other site 757424015640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 757424015641 DNA binding site [nucleotide binding] 757424015642 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 757424015643 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 757424015644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424015645 dimer interface [polypeptide binding]; other site 757424015646 phosphorylation site [posttranslational modification] 757424015647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424015648 ATP binding site [chemical binding]; other site 757424015649 Mg2+ binding site [ion binding]; other site 757424015650 G-X-G motif; other site 757424015651 BON domain; Region: BON; pfam04972 757424015652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 757424015653 response regulator GlrR; Provisional; Region: PRK15115 757424015654 active site 757424015655 phosphorylation site [posttranslational modification] 757424015656 intermolecular recognition site; other site 757424015657 dimerization interface [polypeptide binding]; other site 757424015658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 757424015659 Walker A motif; other site 757424015660 ATP binding site [chemical binding]; other site 757424015661 Walker B motif; other site 757424015662 arginine finger; other site 757424015663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 757424015664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 757424015665 dimerization interface [polypeptide binding]; other site 757424015666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 757424015667 dimer interface [polypeptide binding]; other site 757424015668 phosphorylation site [posttranslational modification] 757424015669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 757424015670 ATP binding site [chemical binding]; other site 757424015671 Mg2+ binding site [ion binding]; other site 757424015672 G-X-G motif; other site 757424015673 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 757424015674 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 757424015675 metal binding site [ion binding]; metal-binding site 757424015676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015677 putative substrate translocation pore; other site 757424015678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 757424015679 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 757424015680 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 757424015681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424015682 Zn2+ binding site [ion binding]; other site 757424015683 Mg2+ binding site [ion binding]; other site 757424015684 Sensors of blue-light using FAD; Region: BLUF; pfam04940 757424015685 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 757424015686 GTP cyclohydrolase I; Provisional; Region: PLN03044 757424015687 active site 757424015688 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 757424015689 Flagellar L-ring protein; Region: FlgH; cl17277 757424015690 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 757424015691 EamA-like transporter family; Region: EamA; pfam00892 757424015692 EamA-like transporter family; Region: EamA; pfam00892 757424015693 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 757424015694 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 757424015695 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 757424015696 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 757424015697 active site 757424015698 non-prolyl cis peptide bond; other site 757424015699 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 757424015700 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 757424015701 Flavin binding site [chemical binding]; other site 757424015702 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 757424015703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 757424015704 active site 757424015705 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 757424015706 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 757424015707 nucleophile elbow; other site 757424015708 Patatin phospholipase; Region: DUF3734; pfam12536 757424015709 Phasin protein; Region: Phasin_2; pfam09361 757424015710 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 757424015711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 757424015712 MarR family; Region: MarR_2; pfam12802 757424015713 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 757424015714 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 757424015715 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 757424015716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424015717 Transcriptional regulators [Transcription]; Region: GntR; COG1802 757424015718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 757424015719 DNA-binding site [nucleotide binding]; DNA binding site 757424015720 FCD domain; Region: FCD; pfam07729 757424015721 Predicted permeases [General function prediction only]; Region: COG0679 757424015722 CHASE domain; Region: CHASE; pfam03924 757424015723 PAS domain; Region: PAS_9; pfam13426 757424015724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 757424015725 putative active site [active] 757424015726 heme pocket [chemical binding]; other site 757424015727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 757424015728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 757424015729 metal binding site [ion binding]; metal-binding site 757424015730 active site 757424015731 I-site; other site 757424015732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 757424015733 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 757424015734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 757424015735 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 757424015736 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 757424015737 dimerization interface [polypeptide binding]; other site 757424015738 active site 757424015739 choline dehydrogenase; Validated; Region: PRK02106 757424015740 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424015741 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 757424015742 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 757424015743 NAD(P) binding site [chemical binding]; other site 757424015744 catalytic residues [active] 757424015745 Fic family protein [Function unknown]; Region: COG3177 757424015746 Fic/DOC family; Region: Fic; pfam02661 757424015747 lipoyl synthase; Provisional; Region: PRK05481 757424015748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 757424015749 FeS/SAM binding site; other site 757424015750 lipoate-protein ligase B; Provisional; Region: PRK14343 757424015751 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 757424015752 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 757424015753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015754 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 757424015755 dimerization interface [polypeptide binding]; other site 757424015756 substrate binding pocket [chemical binding]; other site 757424015757 Protein of unknown function (DUF493); Region: DUF493; cl01102 757424015758 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 757424015759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 757424015760 active site 757424015761 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 757424015762 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 757424015763 homodimer interface [polypeptide binding]; other site 757424015764 substrate-cofactor binding pocket; other site 757424015765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 757424015766 catalytic residue [active] 757424015767 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 757424015768 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 757424015769 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 757424015770 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 757424015771 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 757424015772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 757424015773 dimer interface [polypeptide binding]; other site 757424015774 putative CheW interface [polypeptide binding]; other site 757424015775 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 757424015776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 757424015777 Zn2+ binding site [ion binding]; other site 757424015778 Mg2+ binding site [ion binding]; other site 757424015779 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 757424015780 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 757424015781 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 757424015782 Walker A/P-loop; other site 757424015783 ATP binding site [chemical binding]; other site 757424015784 Q-loop/lid; other site 757424015785 ABC transporter signature motif; other site 757424015786 Walker B; other site 757424015787 D-loop; other site 757424015788 H-loop/switch region; other site 757424015789 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 757424015790 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 757424015791 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 757424015792 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 757424015793 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 757424015794 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 757424015795 ParB-like nuclease domain; Region: ParB; smart00470 757424015796 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 757424015797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 757424015798 P-loop; other site 757424015799 Magnesium ion binding site [ion binding]; other site 757424015800 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 757424015801 Magnesium ion binding site [ion binding]; other site 757424015802 LysE type translocator; Region: LysE; cl00565 757424015803 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 757424015804 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 757424015805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 757424015806 S-adenosylmethionine binding site [chemical binding]; other site 757424015807 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 757424015808 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 757424015809 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 757424015810 hypothetical protein; Provisional; Region: PRK10621 757424015811 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 757424015812 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 757424015813 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 757424015814 TM-ABC transporter signature motif; other site 757424015815 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 757424015816 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 757424015817 TM-ABC transporter signature motif; other site 757424015818 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 757424015819 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 757424015820 putative ligand binding site [chemical binding]; other site 757424015821 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 757424015822 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 757424015823 Walker A/P-loop; other site 757424015824 ATP binding site [chemical binding]; other site 757424015825 Q-loop/lid; other site 757424015826 ABC transporter signature motif; other site 757424015827 Walker B; other site 757424015828 D-loop; other site 757424015829 H-loop/switch region; other site 757424015830 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 757424015831 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 757424015832 Walker A/P-loop; other site 757424015833 ATP binding site [chemical binding]; other site 757424015834 Q-loop/lid; other site 757424015835 ABC transporter signature motif; other site 757424015836 Walker B; other site 757424015837 D-loop; other site 757424015838 H-loop/switch region; other site 757424015839 choline dehydrogenase; Validated; Region: PRK02106 757424015840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 757424015841 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 757424015842 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 757424015843 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 757424015844 tetrameric interface [polypeptide binding]; other site 757424015845 NAD binding site [chemical binding]; other site 757424015846 catalytic residues [active] 757424015847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424015848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 757424015850 dimerization interface [polypeptide binding]; other site 757424015851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 757424015852 catalytic loop [active] 757424015853 iron binding site [ion binding]; other site 757424015854 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 757424015855 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 757424015856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 757424015857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 757424015858 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 757424015859 substrate binding pocket [chemical binding]; other site 757424015860 dimerization interface [polypeptide binding]; other site 757424015861 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 757424015862 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 757424015863 putative active site [active] 757424015864 putative dimer interface [polypeptide binding]; other site