-- dump date 20111121_012614 -- class Genbank::misc_feature -- table misc_feature_note -- id note 316274000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 316274000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000003 Walker A motif; other site 316274000004 ATP binding site [chemical binding]; other site 316274000005 Walker B motif; other site 316274000006 arginine finger; other site 316274000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 316274000008 DnaA box-binding interface [nucleotide binding]; other site 316274000009 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 316274000010 M28 Zn-Peptidases; Region: M28_like_6; cd08656 316274000011 metal binding site [ion binding]; metal-binding site 316274000012 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 316274000013 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 316274000014 metal binding site [ion binding]; metal-binding site 316274000015 dimer interface [polypeptide binding]; other site 316274000016 Colicin V production protein; Region: Colicin_V; cl00567 316274000017 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 316274000018 ADP-ribose binding site [chemical binding]; other site 316274000019 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274000020 CoenzymeA binding site [chemical binding]; other site 316274000021 subunit interaction site [polypeptide binding]; other site 316274000022 PHB binding site; other site 316274000023 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274000024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274000025 motif II; other site 316274000026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000027 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274000028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000029 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000030 diaminopimelate decarboxylase; Region: lysA; TIGR01048 316274000031 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 316274000032 active site 316274000033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274000034 substrate binding site [chemical binding]; other site 316274000035 catalytic residues [active] 316274000036 dimer interface [polypeptide binding]; other site 316274000037 DNA primase; Validated; Region: dnaG; PRK05667 316274000038 CHC2 zinc finger; Region: zf-CHC2; cl02597 316274000039 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 316274000040 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 316274000041 interdomain interaction site; other site 316274000042 active site 316274000043 metal binding site [ion binding]; metal-binding site 316274000044 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 316274000045 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274000046 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274000047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274000048 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274000049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274000050 DNA binding residues [nucleotide binding] 316274000051 Integral membrane protein TerC family; Region: TerC; cl10468 316274000052 Protein of unknown function (DUF418); Region: DUF418; cl12135 316274000053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274000054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274000055 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 316274000056 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 316274000057 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 316274000058 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 316274000059 malonyl-CoA binding site [chemical binding]; other site 316274000060 dimer interface [polypeptide binding]; other site 316274000061 active site 316274000062 product binding site; other site 316274000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000064 active site 316274000065 ATP binding site [chemical binding]; other site 316274000066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274000067 substrate binding site [chemical binding]; other site 316274000068 activation loop (A-loop); other site 316274000069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274000070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000071 active site 316274000072 ATP binding site [chemical binding]; other site 316274000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274000074 substrate binding site [chemical binding]; other site 316274000075 activation loop (A-loop); other site 316274000076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 316274000077 active site 316274000078 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274000079 catalytic residues [active] 316274000080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274000081 catalytic residues [active] 316274000082 MbtH-like protein; Region: MbtH; cl01279 316274000083 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316274000084 Clp amino terminal domain; Region: Clp_N; pfam02861 316274000085 Clp amino terminal domain; Region: Clp_N; pfam02861 316274000086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000087 Walker A motif; other site 316274000088 ATP binding site [chemical binding]; other site 316274000089 Walker B motif; other site 316274000090 arginine finger; other site 316274000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000092 Walker A motif; other site 316274000093 ATP binding site [chemical binding]; other site 316274000094 Walker B motif; other site 316274000095 arginine finger; other site 316274000096 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274000097 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 316274000098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 316274000099 HSP70 interaction site [polypeptide binding]; other site 316274000100 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 316274000101 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 316274000102 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 316274000103 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 316274000104 tetramer interface [polypeptide binding]; other site 316274000105 heme binding pocket [chemical binding]; other site 316274000106 NADPH binding site [chemical binding]; other site 316274000107 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 316274000108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274000109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316274000110 dimerization interface [polypeptide binding]; other site 316274000111 Protein of unknown function (DUF541); Region: SIMPL; cl01077 316274000112 FOG: CBS domain [General function prediction only]; Region: COG0517 316274000113 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 316274000114 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274000115 putative active site [active] 316274000116 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 316274000117 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 316274000118 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316274000119 dimer interface [polypeptide binding]; other site 316274000120 PYR/PP interface [polypeptide binding]; other site 316274000121 TPP binding site [chemical binding]; other site 316274000122 substrate binding site [chemical binding]; other site 316274000123 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 316274000124 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 316274000125 TPP-binding site [chemical binding]; other site 316274000126 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 316274000127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274000128 catalytic core [active] 316274000129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000130 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274000131 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274000132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274000133 cyclase homology domain; Region: CHD; cd07302 316274000134 nucleotidyl binding site; other site 316274000135 metal binding site [ion binding]; metal-binding site 316274000136 dimer interface [polypeptide binding]; other site 316274000137 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274000138 cyclase homology domain; Region: CHD; cd07302 316274000139 nucleotidyl binding site; other site 316274000140 metal binding site [ion binding]; metal-binding site 316274000141 dimer interface [polypeptide binding]; other site 316274000142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000143 binding surface 316274000144 TPR motif; other site 316274000145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000146 binding surface 316274000147 TPR motif; other site 316274000148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000149 binding surface 316274000150 TPR motif; other site 316274000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000152 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 316274000153 Walker A motif; other site 316274000154 ATP binding site [chemical binding]; other site 316274000155 Walker B motif; other site 316274000156 arginine finger; other site 316274000157 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 316274000158 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274000159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274000160 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274000161 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000162 ligand binding site [chemical binding]; other site 316274000163 flexible hinge region; other site 316274000164 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 316274000165 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 316274000166 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 316274000167 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274000168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274000169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000170 homodimer interface [polypeptide binding]; other site 316274000171 catalytic residue [active] 316274000172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274000173 active site 316274000174 phosphorylation site [posttranslational modification] 316274000175 intermolecular recognition site; other site 316274000176 dimerization interface [polypeptide binding]; other site 316274000177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274000178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000179 ATP binding site [chemical binding]; other site 316274000180 Mg2+ binding site [ion binding]; other site 316274000181 G-X-G motif; other site 316274000182 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 316274000183 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274000184 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 316274000185 Putative cyclase; Region: Cyclase; cl00814 316274000186 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 316274000187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274000188 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274000189 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 316274000190 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274000191 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274000192 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 316274000193 IMP binding site; other site 316274000194 dimer interface [polypeptide binding]; other site 316274000195 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 316274000196 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 316274000197 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 316274000198 UvrB/uvrC motif; Region: UVR; pfam02151 316274000199 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 316274000200 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 316274000201 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 316274000202 O-Antigen ligase; Region: Wzy_C; cl04850 316274000203 Leucine carboxyl methyltransferase; Region: LCM; cl01306 316274000204 Protein of unknown function (DUF983); Region: DUF983; cl02211 316274000205 DNA polymerase I; Provisional; Region: PRK05755 316274000206 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316274000207 active site 316274000208 metal binding site 1 [ion binding]; metal-binding site 316274000209 putative 5' ssDNA interaction site; other site 316274000210 metal binding site 3; metal-binding site 316274000211 metal binding site 2 [ion binding]; metal-binding site 316274000212 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316274000213 putative DNA binding site [nucleotide binding]; other site 316274000214 putative metal binding site [ion binding]; other site 316274000215 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 316274000216 active site 316274000217 catalytic site [active] 316274000218 substrate binding site [chemical binding]; other site 316274000219 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 316274000220 active site 316274000221 DNA binding site [nucleotide binding] 316274000222 catalytic site [active] 316274000223 Response regulator receiver domain; Region: Response_reg; pfam00072 316274000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274000225 active site 316274000226 phosphorylation site [posttranslational modification] 316274000227 intermolecular recognition site; other site 316274000228 dimerization interface [polypeptide binding]; other site 316274000229 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274000230 GAF domain; Region: GAF; cl00853 316274000231 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 316274000232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274000233 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 316274000234 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274000235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000236 Walker A motif; other site 316274000237 ATP binding site [chemical binding]; other site 316274000238 Walker B motif; other site 316274000239 arginine finger; other site 316274000240 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274000241 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274000242 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274000243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274000244 putative active site [active] 316274000245 putative metal binding site [ion binding]; other site 316274000246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274000247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274000248 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 316274000249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274000250 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 316274000251 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 316274000252 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274000253 FemAB family; Region: FemAB; cl11444 316274000254 FemAB family; Region: FemAB; cl11444 316274000255 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 316274000256 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274000257 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274000258 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274000259 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 316274000260 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000262 Walker A motif; other site 316274000263 ATP binding site [chemical binding]; other site 316274000264 Walker B motif; other site 316274000265 arginine finger; other site 316274000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000267 binding surface 316274000268 TPR motif; other site 316274000269 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274000270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000271 binding surface 316274000272 TPR motif; other site 316274000273 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274000274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000275 binding surface 316274000276 TPR motif; other site 316274000277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000278 TPR motif; other site 316274000279 binding surface 316274000280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000281 TPR motif; other site 316274000282 binding surface 316274000283 Cupin domain; Region: Cupin_2; cl09118 316274000284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274000285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274000286 AzlC protein; Region: AzlC; cl00570 316274000287 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 316274000288 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 316274000289 active site 316274000290 metal binding site [ion binding]; metal-binding site 316274000291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274000292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274000293 active site 316274000294 phosphorylation site [posttranslational modification] 316274000295 intermolecular recognition site; other site 316274000296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 316274000297 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 316274000298 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 316274000299 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274000300 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 316274000301 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 316274000302 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 316274000303 GatB domain; Region: GatB_Yqey; cl11497 316274000304 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 316274000305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274000306 ATP binding site [chemical binding]; other site 316274000307 putative Mg++ binding site [ion binding]; other site 316274000308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274000309 nucleotide binding region [chemical binding]; other site 316274000310 ATP-binding site [chemical binding]; other site 316274000311 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 316274000312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000313 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000314 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 316274000315 structural tetrad; other site 316274000316 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000317 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 316274000318 structural tetrad; other site 316274000319 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000320 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 316274000321 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274000322 Cytochrome c; Region: Cytochrom_C; cl11414 316274000323 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 316274000324 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 316274000325 D-pathway; other site 316274000326 Putative ubiquinol binding site [chemical binding]; other site 316274000327 Low-spin heme (heme b) binding site [chemical binding]; other site 316274000328 Putative water exit pathway; other site 316274000329 Binuclear center (heme o3/CuB) [ion binding]; other site 316274000330 K-pathway; other site 316274000331 Putative proton exit pathway; other site 316274000332 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 316274000333 Subunit I/III interface [polypeptide binding]; other site 316274000334 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 316274000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274000336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274000337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274000338 dimerization interface [polypeptide binding]; other site 316274000339 putative DNA binding site [nucleotide binding]; other site 316274000340 putative Zn2+ binding site [ion binding]; other site 316274000341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274000342 dimerization interface [polypeptide binding]; other site 316274000343 putative DNA binding site [nucleotide binding]; other site 316274000344 putative Zn2+ binding site [ion binding]; other site 316274000345 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 316274000346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274000348 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 316274000349 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 316274000350 active site 316274000351 Zn binding site [ion binding]; other site 316274000352 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274000353 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 316274000354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274000355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000356 homodimer interface [polypeptide binding]; other site 316274000357 catalytic residue [active] 316274000358 elongation factor Tu; Reviewed; Region: PRK00049 316274000359 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 316274000360 G1 box; other site 316274000361 GEF interaction site [polypeptide binding]; other site 316274000362 GTP/Mg2+ binding site [chemical binding]; other site 316274000363 Switch I region; other site 316274000364 G2 box; other site 316274000365 G3 box; other site 316274000366 Switch II region; other site 316274000367 G4 box; other site 316274000368 G5 box; other site 316274000369 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316274000370 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 316274000371 Antibiotic Binding Site [chemical binding]; other site 316274000372 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 316274000373 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 316274000374 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 316274000375 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 316274000376 putative homodimer interface [polypeptide binding]; other site 316274000377 KOW motif; Region: KOW; cl00354 316274000378 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 316274000379 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 316274000380 23S rRNA interface [nucleotide binding]; other site 316274000381 L7/L12 interface [polypeptide binding]; other site 316274000382 putative thiostrepton binding site; other site 316274000383 L25 interface [polypeptide binding]; other site 316274000384 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 316274000385 mRNA/rRNA interface [nucleotide binding]; other site 316274000386 Amidinotransferase; Region: Amidinotransf; cl12043 316274000387 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 316274000388 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 316274000389 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 316274000390 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274000391 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 316274000392 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316274000393 active site 316274000394 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316274000395 active site 316274000396 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 316274000397 homodecamer interface [polypeptide binding]; other site 316274000398 GTP cyclohydrolase I; Provisional; Region: PLN03044 316274000399 active site 316274000400 putative catalytic site residues [active] 316274000401 zinc binding site [ion binding]; other site 316274000402 GTP-CH-I/GFRP interaction surface; other site 316274000403 classical (c) SDRs; Region: SDR_c; cd05233 316274000404 NAD(P) binding site [chemical binding]; other site 316274000405 active site 316274000406 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274000407 isocitrate dehydrogenase; Validated; Region: PRK06451 316274000408 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274000409 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274000410 putative active site [active] 316274000411 putative NTP binding site [chemical binding]; other site 316274000412 putative nucleic acid binding site [nucleotide binding]; other site 316274000413 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274000414 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 316274000415 active site 316274000416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000417 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 316274000418 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274000419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000420 binding surface 316274000421 TPR motif; other site 316274000422 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 316274000423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274000424 inhibitor-cofactor binding pocket; inhibition site 316274000425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000426 catalytic residue [active] 316274000427 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 316274000428 23S rRNA interface [nucleotide binding]; other site 316274000429 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 316274000430 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 316274000431 core dimer interface [polypeptide binding]; other site 316274000432 peripheral dimer interface [polypeptide binding]; other site 316274000433 L10 interface [polypeptide binding]; other site 316274000434 L11 interface [polypeptide binding]; other site 316274000435 putative EF-Tu interaction site [polypeptide binding]; other site 316274000436 putative EF-G interaction site [polypeptide binding]; other site 316274000437 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 316274000438 ATP binding site [chemical binding]; other site 316274000439 substrate binding site [chemical binding]; other site 316274000440 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316274000441 homotrimer interaction site [polypeptide binding]; other site 316274000442 putative active site [active] 316274000443 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 316274000444 enolase; Provisional; Region: eno; PRK00077 316274000445 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 316274000446 dimer interface [polypeptide binding]; other site 316274000447 metal binding site [ion binding]; metal-binding site 316274000448 substrate binding pocket [chemical binding]; other site 316274000449 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 316274000450 nucleotide binding site [chemical binding]; other site 316274000451 N-acetyl-L-glutamate binding site [chemical binding]; other site 316274000452 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 316274000453 ATP binding site [chemical binding]; other site 316274000454 substrate binding site [chemical binding]; other site 316274000455 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274000456 nudix motif; other site 316274000457 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316274000458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274000459 LexA repressor; Validated; Region: PRK00215 316274000460 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 316274000461 Catalytic site [active] 316274000462 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 316274000463 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 316274000464 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 316274000465 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 316274000466 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 316274000467 putative active site [active] 316274000468 oxyanion strand; other site 316274000469 catalytic triad [active] 316274000470 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 316274000471 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 316274000472 catalytic residues [active] 316274000473 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274000474 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 316274000475 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 316274000476 substrate binding site [chemical binding]; other site 316274000477 glutamase interaction surface [polypeptide binding]; other site 316274000478 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 316274000479 MoaE interaction surface [polypeptide binding]; other site 316274000480 MoeB interaction surface [polypeptide binding]; other site 316274000481 thiocarboxylated glycine; other site 316274000482 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 316274000483 MoaE homodimer interface [polypeptide binding]; other site 316274000484 MoaD interaction [polypeptide binding]; other site 316274000485 active site residues [active] 316274000486 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274000487 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274000488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274000489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274000490 DNA binding residues [nucleotide binding] 316274000491 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 316274000492 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274000493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274000494 S-adenosylmethionine binding site [chemical binding]; other site 316274000495 Protein of unknown function (DUF433); Region: DUF433; cl01030 316274000496 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274000497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274000498 motif II; other site 316274000499 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 316274000500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274000501 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274000502 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000503 ligand binding site [chemical binding]; other site 316274000504 flexible hinge region; other site 316274000505 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 316274000506 catalytic residue [active] 316274000507 putative FPP diphosphate binding site; other site 316274000508 putative FPP binding hydrophobic cleft; other site 316274000509 dimer interface [polypeptide binding]; other site 316274000510 putative IPP diphosphate binding site; other site 316274000511 LysE type translocator; Region: LysE; cl00565 316274000512 phage shock protein A; Region: phageshock_pspA; TIGR02977 316274000513 phage shock protein PspA; Provisional; Region: PRK10698 316274000514 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 316274000515 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 316274000516 lipoyl synthase; Provisional; Region: PRK05481 316274000517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274000518 FeS/SAM binding site; other site 316274000519 DNA repair protein RadA; Provisional; Region: PRK11823 316274000520 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 316274000521 Walker A motif/ATP binding site; other site 316274000522 ATP binding site [chemical binding]; other site 316274000523 Walker B motif; other site 316274000524 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 316274000525 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 316274000526 putative active site [active] 316274000527 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 316274000528 putative active site [active] 316274000529 dimerization interface [polypeptide binding]; other site 316274000530 putative tRNAtyr binding site [nucleotide binding]; other site 316274000531 Double zinc ribbon; Region: DZR; pfam12773 316274000532 conserved hypothetical protein; Region: glmL_fam; TIGR01319 316274000533 large tegument protein UL36; Provisional; Region: PHA03247 316274000534 Domain of unknown function DUF11; Region: DUF11; cl03172 316274000535 Domain of unknown function DUF11; Region: DUF11; cl03172 316274000536 Chain length determinant protein; Region: Wzz; cl01623 316274000537 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 316274000538 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274000539 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 316274000540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000541 binding surface 316274000542 TPR motif; other site 316274000543 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274000544 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 316274000545 DinB superfamily; Region: DinB_2; cl00986 316274000546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274000547 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274000548 Probable transposase; Region: OrfB_IS605; pfam01385 316274000549 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 316274000550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274000551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274000552 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 316274000553 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 316274000554 Response regulator receiver domain; Region: Response_reg; pfam00072 316274000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274000556 active site 316274000557 phosphorylation site [posttranslational modification] 316274000558 intermolecular recognition site; other site 316274000559 dimerization interface [polypeptide binding]; other site 316274000560 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 316274000561 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 316274000562 active site 316274000563 catalytic site [active] 316274000564 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 316274000565 phosphate binding site [ion binding]; other site 316274000566 putative substrate binding pocket [chemical binding]; other site 316274000567 dimer interface [polypeptide binding]; other site 316274000568 NurA domain; Region: NurA; cl09134 316274000569 HAS barrel domain; Region: HAS-barrel; pfam09378 316274000570 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274000571 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274000572 cyclase homology domain; Region: CHD; cd07302 316274000573 nucleotidyl binding site; other site 316274000574 metal binding site [ion binding]; metal-binding site 316274000575 dimer interface [polypeptide binding]; other site 316274000576 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274000577 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274000578 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 316274000579 Walker A/P-loop; other site 316274000580 ATP binding site [chemical binding]; other site 316274000581 Q-loop/lid; other site 316274000582 ABC transporter signature motif; other site 316274000583 Walker B; other site 316274000584 D-loop; other site 316274000585 H-loop/switch region; other site 316274000586 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274000587 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274000588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000589 Walker A/P-loop; other site 316274000590 ATP binding site [chemical binding]; other site 316274000591 Q-loop/lid; other site 316274000592 ABC transporter signature motif; other site 316274000593 Walker B; other site 316274000594 D-loop; other site 316274000595 H-loop/switch region; other site 316274000596 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 316274000597 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 316274000598 active site 316274000599 HIGH motif; other site 316274000600 dimer interface [polypeptide binding]; other site 316274000601 KMSKS motif; other site 316274000602 cytoskeletal protein RodZ; Provisional; Region: PRK10856 316274000603 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274000604 tryptophan synthase, beta chain; Region: PLN02618 316274000605 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 316274000606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000607 catalytic residue [active] 316274000608 Bacterial SH3 domain; Region: SH3_3; cl02551 316274000609 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 316274000610 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274000611 active site 316274000612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274000613 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 316274000614 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 316274000615 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 316274000616 active site 316274000617 substrate binding site [chemical binding]; other site 316274000618 FMN binding site [chemical binding]; other site 316274000619 putative catalytic residues [active] 316274000620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274000621 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 316274000622 Walker A/P-loop; other site 316274000623 ATP binding site [chemical binding]; other site 316274000624 Q-loop/lid; other site 316274000625 ABC transporter signature motif; other site 316274000626 Walker B; other site 316274000627 D-loop; other site 316274000628 H-loop/switch region; other site 316274000629 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 316274000630 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 316274000631 Walker A/P-loop; other site 316274000632 ATP binding site [chemical binding]; other site 316274000633 Q-loop/lid; other site 316274000634 ABC transporter signature motif; other site 316274000635 Walker B; other site 316274000636 D-loop; other site 316274000637 H-loop/switch region; other site 316274000638 phage shock protein PspA; Provisional; Region: PRK10698 316274000639 phage shock protein A; Region: phageshock_pspA; TIGR02977 316274000640 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 316274000641 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 316274000642 putative peptidoglycan binding site; other site 316274000643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000644 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_4; cd03795 316274000645 putative ADP-binding pocket [chemical binding]; other site 316274000646 Protein kinase; unclassified specificity; Region: STYKc; smart00221 316274000647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000648 active site 316274000649 ATP binding site [chemical binding]; other site 316274000650 substrate binding site [chemical binding]; other site 316274000651 activation loop (A-loop); other site 316274000652 Protein kinase; unclassified specificity; Region: STYKc; smart00221 316274000653 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000654 active site 316274000655 ATP binding site [chemical binding]; other site 316274000656 substrate binding site [chemical binding]; other site 316274000657 activation loop (A-loop); other site 316274000658 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 316274000659 dimer interface [polypeptide binding]; other site 316274000660 active site 316274000661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274000662 active site 316274000663 motif I; other site 316274000664 motif II; other site 316274000665 Domain of unknown function (DUF74); Region: DUF74; cl00426 316274000666 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 316274000667 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 316274000668 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 316274000669 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 316274000670 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 316274000671 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 316274000672 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316274000673 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 316274000674 G-loop; other site 316274000675 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 316274000676 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316274000677 DNA binding site [nucleotide binding] 316274000678 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 316274000679 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 316274000680 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 316274000681 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 316274000682 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 316274000683 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 316274000684 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 316274000685 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 316274000686 RPB12 interaction site [polypeptide binding]; other site 316274000687 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 316274000688 RPB10 interaction site [polypeptide binding]; other site 316274000689 RPB1 interaction site [polypeptide binding]; other site 316274000690 RPB11 interaction site [polypeptide binding]; other site 316274000691 RPB3 interaction site [polypeptide binding]; other site 316274000692 RPB12 interaction site [polypeptide binding]; other site 316274000693 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 316274000694 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 316274000695 active site 316274000696 Riboflavin kinase; Region: Flavokinase; pfam01687 316274000697 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274000698 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274000699 DNA binding residues [nucleotide binding] 316274000700 drug binding residues [chemical binding]; other site 316274000701 dimer interface [polypeptide binding]; other site 316274000702 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 316274000703 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274000704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274000705 Coenzyme A binding pocket [chemical binding]; other site 316274000706 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274000707 metal ion-dependent adhesion site (MIDAS); other site 316274000708 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274000709 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274000710 metal ion-dependent adhesion site (MIDAS); other site 316274000711 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274000712 FixH; Region: FixH; cl01254 316274000713 Aerotolerance regulator N-terminal; Region: BatA; cl06567 316274000714 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274000715 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274000716 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274000717 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274000718 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274000719 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274000720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274000721 Walker A motif; other site 316274000722 ATP binding site [chemical binding]; other site 316274000723 Walker B motif; other site 316274000724 arginine finger; other site 316274000725 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274000726 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 316274000727 sulfate transport protein; Provisional; Region: cysT; CHL00187 316274000728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274000729 dimer interface [polypeptide binding]; other site 316274000730 conserved gate region; other site 316274000731 putative PBP binding loops; other site 316274000732 ABC-ATPase subunit interface; other site 316274000733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274000734 dimer interface [polypeptide binding]; other site 316274000735 conserved gate region; other site 316274000736 putative PBP binding loops; other site 316274000737 ABC-ATPase subunit interface; other site 316274000738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274000739 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 316274000740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000741 Walker A/P-loop; other site 316274000742 ATP binding site [chemical binding]; other site 316274000743 Q-loop/lid; other site 316274000744 ABC transporter signature motif; other site 316274000745 Walker B; other site 316274000746 D-loop; other site 316274000747 H-loop/switch region; other site 316274000748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274000749 Ligand Binding Site [chemical binding]; other site 316274000750 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 316274000751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274000752 glutamate formiminotransferase; Region: FtcD; TIGR02024 316274000753 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 316274000754 Formiminotransferase domain; Region: FTCD; pfam02971 316274000755 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 316274000756 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316274000757 active site 316274000758 NTP binding site [chemical binding]; other site 316274000759 metal binding triad [ion binding]; metal-binding site 316274000760 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316274000761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274000762 Cupin domain; Region: Cupin_2; cl09118 316274000763 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 316274000764 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 316274000765 ADP binding site [chemical binding]; other site 316274000766 magnesium binding site [ion binding]; other site 316274000767 putative shikimate binding site; other site 316274000768 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 316274000769 active site 316274000770 dimer interface [polypeptide binding]; other site 316274000771 metal binding site [ion binding]; metal-binding site 316274000772 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 316274000773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274000774 S-adenosylmethionine binding site [chemical binding]; other site 316274000775 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274000776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274000778 TPR motif; other site 316274000779 binding surface 316274000780 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274000781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274000782 Low affinity iron permease; Region: Iron_permease; cl12096 316274000783 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 316274000784 Cupin domain; Region: Cupin_2; cl09118 316274000785 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274000786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274000787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000788 ATP binding site [chemical binding]; other site 316274000789 Mg2+ binding site [ion binding]; other site 316274000790 G-X-G motif; other site 316274000791 XisI protein; Region: XisI; pfam08869 316274000792 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000793 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 316274000794 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 316274000795 active site 316274000796 EamA-like transporter family; Region: EamA; cl01037 316274000797 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274000798 EamA-like transporter family; Region: EamA; cl01037 316274000799 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 316274000800 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 316274000801 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 316274000802 generic binding surface II; other site 316274000803 ssDNA binding site; other site 316274000804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274000805 ATP binding site [chemical binding]; other site 316274000806 putative Mg++ binding site [ion binding]; other site 316274000807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274000808 nucleotide binding region [chemical binding]; other site 316274000809 ATP-binding site [chemical binding]; other site 316274000810 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 316274000811 elongation factor G; Reviewed; Region: PRK12740 316274000812 G1 box; other site 316274000813 putative GEF interaction site [polypeptide binding]; other site 316274000814 GTP/Mg2+ binding site [chemical binding]; other site 316274000815 Switch I region; other site 316274000816 G2 box; other site 316274000817 G3 box; other site 316274000818 Switch II region; other site 316274000819 G4 box; other site 316274000820 G5 box; other site 316274000821 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 316274000822 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 316274000823 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 316274000824 integral membrane protein MviN; Region: mviN; TIGR01695 316274000825 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274000826 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274000827 Cellulose binding domain; Region: CBM_2; cl02709 316274000828 Cellulose binding domain; Region: CBM_2; cl02709 316274000829 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 316274000830 endoglucanase; Region: PLN02308 316274000831 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 316274000832 Cellulose binding domain; Region: CBM_3; pfam00942 316274000833 Cellulose binding domain; Region: CBM_2; cl02709 316274000834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274000835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274000836 DNA binding site [nucleotide binding] 316274000837 domain linker motif; other site 316274000838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274000839 dimerization interface [polypeptide binding]; other site 316274000840 ligand binding site [chemical binding]; other site 316274000841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274000842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274000843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274000844 dimer interface [polypeptide binding]; other site 316274000845 conserved gate region; other site 316274000846 putative PBP binding loops; other site 316274000847 ABC-ATPase subunit interface; other site 316274000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274000849 dimer interface [polypeptide binding]; other site 316274000850 conserved gate region; other site 316274000851 putative PBP binding loops; other site 316274000852 ABC-ATPase subunit interface; other site 316274000853 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 316274000854 Protein of unknown function, DUF608; Region: DUF608; pfam04685 316274000855 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 316274000856 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 316274000857 L11 interface [polypeptide binding]; other site 316274000858 putative EF-Tu interaction site [polypeptide binding]; other site 316274000859 putative EF-G interaction site [polypeptide binding]; other site 316274000860 Rdx family; Region: Rdx; cl01407 316274000861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274000862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274000863 NAD(P) binding site [chemical binding]; other site 316274000864 active site 316274000865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274000866 GAF domain; Region: GAF; cl00853 316274000867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274000868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274000869 dimer interface [polypeptide binding]; other site 316274000870 phosphorylation site [posttranslational modification] 316274000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000872 ATP binding site [chemical binding]; other site 316274000873 Mg2+ binding site [ion binding]; other site 316274000874 G-X-G motif; other site 316274000875 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000876 ligand binding site [chemical binding]; other site 316274000877 flexible hinge region; other site 316274000878 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316274000879 Predicted integral membrane protein [Function unknown]; Region: COG5637 316274000880 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 316274000881 putative hydrophobic ligand binding site [chemical binding]; other site 316274000882 Protein of unknown function (DUF419); Region: DUF419; cl09948 316274000883 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 316274000884 putative active site [active] 316274000885 catalytic residue [active] 316274000886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274000887 S-adenosylmethionine binding site [chemical binding]; other site 316274000888 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316274000889 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274000890 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274000891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274000892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274000893 Zn2+ binding site [ion binding]; other site 316274000894 Mg2+ binding site [ion binding]; other site 316274000895 heat shock protein 90; Provisional; Region: PRK05218 316274000896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274000897 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 316274000898 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 316274000899 Cellulose binding domain; Region: CBM_2; cl02709 316274000900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274000901 Domain of unknown function DUF59; Region: DUF59; cl00941 316274000902 antiporter inner membrane protein; Provisional; Region: PRK11670 316274000903 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 316274000904 Walker A motif; other site 316274000905 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 316274000906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274000907 FeS/SAM binding site; other site 316274000908 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 316274000909 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 316274000910 hydrophobic ligand binding site; other site 316274000911 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274000912 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274000913 hypothetical protein; Provisional; Region: PRK10279 316274000914 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274000915 nucleophile elbow; other site 316274000916 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274000917 Protein kinase domain; Region: Pkinase; pfam00069 316274000918 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000919 active site 316274000920 ATP binding site [chemical binding]; other site 316274000921 substrate binding site [chemical binding]; other site 316274000922 activation loop (A-loop); other site 316274000923 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 316274000924 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 316274000925 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274000926 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274000927 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 316274000928 Walker A/P-loop; other site 316274000929 ATP binding site [chemical binding]; other site 316274000930 Q-loop/lid; other site 316274000931 ABC transporter signature motif; other site 316274000932 Walker B; other site 316274000933 D-loop; other site 316274000934 H-loop/switch region; other site 316274000935 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274000936 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 316274000937 putative NAD(P) binding site [chemical binding]; other site 316274000938 structural Zn binding site [ion binding]; other site 316274000939 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 316274000940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274000941 catalytic loop [active] 316274000942 iron binding site [ion binding]; other site 316274000943 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274000944 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274000945 active site 316274000946 catalytic tetrad [active] 316274000947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274000948 Active site [active] 316274000949 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 316274000950 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 316274000951 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274000952 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274000953 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274000954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 316274000955 protein binding site [polypeptide binding]; other site 316274000956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274000957 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 316274000958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274000959 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 316274000960 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 316274000961 Walker A/P-loop; other site 316274000962 ATP binding site [chemical binding]; other site 316274000963 Q-loop/lid; other site 316274000964 ABC transporter signature motif; other site 316274000965 Walker B; other site 316274000966 D-loop; other site 316274000967 H-loop/switch region; other site 316274000968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274000969 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 316274000970 fatty acid metabolism regulator; Provisional; Region: PRK04984 316274000971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274000972 DNA-binding site [nucleotide binding]; DNA binding site 316274000973 FCD domain; Region: FCD; cl11656 316274000974 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316274000975 FAD binding domain; Region: FAD_binding_4; pfam01565 316274000976 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 316274000977 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316274000978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274000979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274000980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274000981 active site 316274000982 catalytic tetrad [active] 316274000983 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274000984 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274000985 homodimer interface [polypeptide binding]; other site 316274000986 active site 316274000987 TDP-binding site; other site 316274000988 acceptor substrate-binding pocket; other site 316274000989 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 316274000990 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 316274000991 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 316274000992 DAK2 domain; Region: Dak2; cl03685 316274000993 Protein of unknown function (DUF322); Region: DUF322; cl00574 316274000994 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 316274000995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274000996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274000997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274000998 DNA binding residues [nucleotide binding] 316274000999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274001000 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274001001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274001002 dimer interface [polypeptide binding]; other site 316274001003 conserved gate region; other site 316274001004 putative PBP binding loops; other site 316274001005 ABC-ATPase subunit interface; other site 316274001006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274001007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274001008 dimer interface [polypeptide binding]; other site 316274001009 conserved gate region; other site 316274001010 putative PBP binding loops; other site 316274001011 ABC-ATPase subunit interface; other site 316274001012 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274001013 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 316274001014 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274001015 classical (c) SDRs; Region: SDR_c; cd05233 316274001016 NAD(P) binding site [chemical binding]; other site 316274001017 active site 316274001018 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 316274001019 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316274001020 dimer interface [polypeptide binding]; other site 316274001021 active site 316274001022 CoA binding pocket [chemical binding]; other site 316274001023 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274001024 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274001025 homodimer interface [polypeptide binding]; other site 316274001026 active site 316274001027 TDP-binding site; other site 316274001028 acceptor substrate-binding pocket; other site 316274001029 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274001030 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274001031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001032 NAD(P) binding site [chemical binding]; other site 316274001033 active site 316274001034 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274001035 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274001036 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 316274001037 G1 box; other site 316274001038 GTP/Mg2+ binding site [chemical binding]; other site 316274001039 G2 box; other site 316274001040 Switch I region; other site 316274001041 G3 box; other site 316274001042 Switch II region; other site 316274001043 G4 box; other site 316274001044 G5 box; other site 316274001045 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274001046 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 316274001047 heme-binding site [chemical binding]; other site 316274001048 UV-endonuclease UvdE; Region: UvdE; cl10036 316274001049 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316274001050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274001051 motif II; other site 316274001052 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 316274001053 tetramerization interface [polypeptide binding]; other site 316274001054 active site 316274001055 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 316274001056 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 316274001057 dimer interface [polypeptide binding]; other site 316274001058 putative functional site; other site 316274001059 putative MPT binding site; other site 316274001060 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 316274001061 putative active site [active] 316274001062 catalytic site [active] 316274001063 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 316274001064 putative active site [active] 316274001065 catalytic site [active] 316274001066 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 316274001067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001068 Walker A motif; other site 316274001069 ATP binding site [chemical binding]; other site 316274001070 Walker B motif; other site 316274001071 arginine finger; other site 316274001072 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 316274001073 putative homotetramer interface [polypeptide binding]; other site 316274001074 putative homodimer interface [polypeptide binding]; other site 316274001075 allosteric switch controlling residues; other site 316274001076 putative metal binding site [ion binding]; other site 316274001077 putative homodimer-homodimer interface [polypeptide binding]; other site 316274001078 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274001079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274001080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274001081 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274001082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274001083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274001084 DNA binding residues [nucleotide binding] 316274001085 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 316274001086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001087 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 316274001088 putative dimerization interface [polypeptide binding]; other site 316274001089 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274001090 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 316274001091 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274001092 metal ion-dependent adhesion site (MIDAS); other site 316274001093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274001094 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274001095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274001096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001097 ATP binding site [chemical binding]; other site 316274001098 Mg2+ binding site [ion binding]; other site 316274001099 G-X-G motif; other site 316274001100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274001101 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 316274001102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274001103 active site 316274001104 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 316274001105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274001106 active site 316274001107 major vault protein; Provisional; Region: PTZ00491 316274001108 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 316274001109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274001110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274001111 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316274001112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001113 NAD(P) binding site [chemical binding]; other site 316274001114 active site 316274001115 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 316274001116 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 316274001117 active site residue [active] 316274001118 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 316274001119 active site residue [active] 316274001120 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 316274001121 [2Fe-2S] cluster binding site [ion binding]; other site 316274001122 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 316274001123 FeS assembly protein SufB; Region: sufB; TIGR01980 316274001124 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316274001125 trimerization site [polypeptide binding]; other site 316274001126 active site 316274001127 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274001128 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 316274001129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274001130 catalytic residue [active] 316274001131 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 316274001132 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 316274001133 FeS assembly ATPase SufC; Region: sufC; TIGR01978 316274001134 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 316274001135 Walker A/P-loop; other site 316274001136 ATP binding site [chemical binding]; other site 316274001137 Q-loop/lid; other site 316274001138 ABC transporter signature motif; other site 316274001139 Walker B; other site 316274001140 D-loop; other site 316274001141 H-loop/switch region; other site 316274001142 Predicted transcriptional regulator [Transcription]; Region: COG2345 316274001143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001145 large tegument protein UL36; Provisional; Region: PHA03247 316274001146 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 316274001147 generic binding surface I; other site 316274001148 generic binding surface II; other site 316274001149 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274001150 putative catalytic site [active] 316274001151 putative metal binding site [ion binding]; other site 316274001152 putative phosphate binding site [ion binding]; other site 316274001153 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274001154 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 316274001155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274001156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001157 Walker A/P-loop; other site 316274001158 ATP binding site [chemical binding]; other site 316274001159 Q-loop/lid; other site 316274001160 ABC transporter signature motif; other site 316274001161 Walker B; other site 316274001162 D-loop; other site 316274001163 H-loop/switch region; other site 316274001164 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 316274001165 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 316274001166 active site 316274001167 substrate-binding site [chemical binding]; other site 316274001168 metal-binding site [ion binding] 316274001169 GTP binding site [chemical binding]; other site 316274001170 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 316274001171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001172 Walker A/P-loop; other site 316274001173 ATP binding site [chemical binding]; other site 316274001174 Q-loop/lid; other site 316274001175 ABC transporter signature motif; other site 316274001176 Walker B; other site 316274001177 D-loop; other site 316274001178 H-loop/switch region; other site 316274001179 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 316274001180 Protein of unknown function (DUF990); Region: DUF990; cl01496 316274001181 Protein of unknown function (DUF990); Region: DUF990; cl01496 316274001182 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 316274001183 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 316274001184 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 316274001185 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 316274001186 active site 316274001187 Zn binding site [ion binding]; other site 316274001188 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 316274001189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001190 HrcA protein C terminal domain; Region: HrcA; pfam01628 316274001191 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 316274001192 dimer interface [polypeptide binding]; other site 316274001193 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 316274001194 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316274001195 chaperone protein DnaJ; Provisional; Region: PRK10767 316274001196 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 316274001197 HSP70 interaction site [polypeptide binding]; other site 316274001198 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 316274001199 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 316274001200 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 316274001201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 316274001202 substrate binding pocket [chemical binding]; other site 316274001203 membrane-bound complex binding site; other site 316274001204 hinge residues; other site 316274001205 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 316274001206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274001207 dimer interface [polypeptide binding]; other site 316274001208 phosphorylation site [posttranslational modification] 316274001209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001210 ATP binding site [chemical binding]; other site 316274001211 Mg2+ binding site [ion binding]; other site 316274001212 G-X-G motif; other site 316274001213 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001215 active site 316274001216 phosphorylation site [posttranslational modification] 316274001217 intermolecular recognition site; other site 316274001218 dimerization interface [polypeptide binding]; other site 316274001219 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316274001220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274001221 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274001222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274001223 active site 316274001224 catalytic tetrad [active] 316274001225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274001226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001227 active site 316274001228 phosphorylation site [posttranslational modification] 316274001229 intermolecular recognition site; other site 316274001230 dimerization interface [polypeptide binding]; other site 316274001231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274001232 DNA binding site [nucleotide binding] 316274001233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274001234 dimer interface [polypeptide binding]; other site 316274001235 phosphorylation site [posttranslational modification] 316274001236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001237 ATP binding site [chemical binding]; other site 316274001238 Mg2+ binding site [ion binding]; other site 316274001239 G-X-G motif; other site 316274001240 OsmC-like protein; Region: OsmC; cl00767 316274001241 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001242 GAF domain; Region: GAF; cl00853 316274001243 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274001244 integral membrane protein MviN; Region: mviN; TIGR01695 316274001245 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274001246 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316274001247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274001248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274001249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274001250 DNA binding site [nucleotide binding] 316274001251 domain linker motif; other site 316274001252 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274001253 dimerization interface [polypeptide binding]; other site 316274001254 ligand binding site [chemical binding]; other site 316274001255 MatE; Region: MatE; pfam01554 316274001256 MatE; Region: MatE; pfam01554 316274001257 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001258 Phosphotransferase enzyme family; Region: APH; pfam01636 316274001259 active site 316274001260 substrate binding site [chemical binding]; other site 316274001261 ATP binding site [chemical binding]; other site 316274001262 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 316274001263 DoxX; Region: DoxX; cl00976 316274001264 Iron permease FTR1 family; Region: FTR1; cl00475 316274001265 Imelysin; Region: Peptidase_M75; cl09159 316274001266 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316274001267 Domain of unknown function DUF21; Region: DUF21; pfam01595 316274001268 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316274001269 Transporter associated domain; Region: CorC_HlyC; pfam03471 316274001270 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274001271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001272 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 316274001273 NusA N-terminal domain; Region: NusA_N; pfam08529 316274001274 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 316274001275 RNA binding site [nucleotide binding]; other site 316274001276 homodimer interface [polypeptide binding]; other site 316274001277 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316274001278 G-X-X-G motif; other site 316274001279 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 316274001280 putative RNA binding cleft [nucleotide binding]; other site 316274001281 translation initiation factor IF-2; Region: IF-2; TIGR00487 316274001282 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316274001283 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 316274001284 G1 box; other site 316274001285 putative GEF interaction site [polypeptide binding]; other site 316274001286 GTP/Mg2+ binding site [chemical binding]; other site 316274001287 Switch I region; other site 316274001288 G2 box; other site 316274001289 G3 box; other site 316274001290 Switch II region; other site 316274001291 G4 box; other site 316274001292 G5 box; other site 316274001293 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 316274001294 Translation-initiation factor 2; Region: IF-2; pfam11987 316274001295 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 316274001296 Ribosome-binding factor A; Region: RBFA; cl00542 316274001297 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 316274001298 DHH family; Region: DHH; pfam01368 316274001299 DHHA1 domain; Region: DHHA1; pfam02272 316274001300 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 316274001301 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 316274001302 RNA binding site [nucleotide binding]; other site 316274001303 active site 316274001304 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274001305 metal ion-dependent adhesion site (MIDAS); other site 316274001306 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274001307 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001308 active site 316274001309 ATP binding site [chemical binding]; other site 316274001310 substrate binding site [chemical binding]; other site 316274001311 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001312 substrate binding site [chemical binding]; other site 316274001313 activation loop (A-loop); other site 316274001314 activation loop (A-loop); other site 316274001315 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274001316 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274001317 chromosome segregation protein; Provisional; Region: PRK02224 316274001318 transketolase; Reviewed; Region: PRK05899 316274001319 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316274001320 TPP-binding site [chemical binding]; other site 316274001321 dimer interface [polypeptide binding]; other site 316274001322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316274001323 PYR/PP interface [polypeptide binding]; other site 316274001324 dimer interface [polypeptide binding]; other site 316274001325 TPP binding site [chemical binding]; other site 316274001326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274001327 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 316274001328 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274001329 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 316274001330 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 316274001331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274001332 ligand binding site [chemical binding]; other site 316274001333 flexible hinge region; other site 316274001334 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274001335 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274001336 hypothetical protein; Provisional; Region: PRK07338 316274001337 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 316274001338 metal binding site [ion binding]; metal-binding site 316274001339 dimer interface [polypeptide binding]; other site 316274001340 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 316274001341 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 316274001342 putative active site [active] 316274001343 putative FMN binding site [chemical binding]; other site 316274001344 putative substrate binding site [chemical binding]; other site 316274001345 putative catalytic residue [active] 316274001346 Double zinc ribbon; Region: DZR; pfam12773 316274001347 thymidylate kinase; Validated; Region: tmk; PRK00698 316274001348 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 316274001349 TMP-binding site; other site 316274001350 ATP-binding site [chemical binding]; other site 316274001351 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 316274001352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001353 Walker A motif; other site 316274001354 ATP binding site [chemical binding]; other site 316274001355 Walker B motif; other site 316274001356 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 316274001357 RxxxH motif; other site 316274001358 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316274001359 RNA binding site [nucleotide binding]; other site 316274001360 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316274001361 RNA binding site [nucleotide binding]; other site 316274001362 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 316274001363 RNA binding site [nucleotide binding]; other site 316274001364 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 316274001365 RNA binding site [nucleotide binding]; other site 316274001366 Clp protease ATP binding subunit; Region: clpC; CHL00095 316274001367 Clp amino terminal domain; Region: Clp_N; pfam02861 316274001368 Clp amino terminal domain; Region: Clp_N; pfam02861 316274001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001370 Walker A motif; other site 316274001371 ATP binding site [chemical binding]; other site 316274001372 Walker B motif; other site 316274001373 arginine finger; other site 316274001374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001375 Walker A motif; other site 316274001376 ATP binding site [chemical binding]; other site 316274001377 Walker B motif; other site 316274001378 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274001379 YceI-like domain; Region: YceI; cl01001 316274001380 Phosphotransferase enzyme family; Region: APH; pfam01636 316274001381 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001382 active site 316274001383 ATP binding site [chemical binding]; other site 316274001384 substrate binding site [chemical binding]; other site 316274001385 cystathionine gamma-synthase; Provisional; Region: PRK07811 316274001386 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316274001387 homodimer interface [polypeptide binding]; other site 316274001388 substrate-cofactor binding pocket; other site 316274001389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274001390 catalytic residue [active] 316274001391 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 316274001392 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 316274001393 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274001394 active site 316274001395 nucleotide binding site [chemical binding]; other site 316274001396 HIGH motif; other site 316274001397 KMSKS motif; other site 316274001398 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 316274001399 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 316274001400 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 316274001401 cleavage site 316274001402 active site 316274001403 substrate binding sites [chemical binding]; other site 316274001404 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274001405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274001406 non-specific DNA binding site [nucleotide binding]; other site 316274001407 salt bridge; other site 316274001408 sequence-specific DNA binding site [nucleotide binding]; other site 316274001409 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 316274001410 FOG: WD40-like repeat [Function unknown]; Region: COG1520 316274001411 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 316274001412 putative acyltransferase; Provisional; Region: PRK05790 316274001413 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274001414 dimer interface [polypeptide binding]; other site 316274001415 active site 316274001416 hypothetical protein; Validated; Region: PRK08116 316274001417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274001419 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274001420 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 316274001421 cofactor binding site; other site 316274001422 DNA binding site [nucleotide binding] 316274001423 substrate interaction site [chemical binding]; other site 316274001424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274001425 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 316274001426 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 316274001427 PRTRC system protein B; Region: PRTRC_B; TIGR03737 316274001428 Domain of unknown function (DUF2016); Region: DUF2016; cl09677 316274001429 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 316274001430 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 316274001431 ATP binding site [chemical binding]; other site 316274001432 substrate interface [chemical binding]; other site 316274001433 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 316274001434 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 316274001435 Protein of unknown function DUF262; Region: DUF262; cl14890 316274001436 Protein of unknown function DUF262; Region: DUF262; cl14890 316274001437 Protein of unknown function DUF262; Region: DUF262; cl14890 316274001438 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001439 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 316274001440 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 316274001441 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 316274001442 Phage-related protein [Function unknown]; Region: COG5412 316274001443 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 316274001444 large terminase protein; Provisional; Region: 17; PHA02533 316274001445 Terminase small subunit; Region: Terminase_2; cl01513 316274001446 DinB superfamily; Region: DinB_2; cl00986 316274001447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274001448 dimerization interface [polypeptide binding]; other site 316274001449 putative DNA binding site [nucleotide binding]; other site 316274001450 putative Zn2+ binding site [ion binding]; other site 316274001451 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 316274001452 putative hydrophobic ligand binding site [chemical binding]; other site 316274001453 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274001454 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274001455 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 316274001456 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274001457 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274001458 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 316274001459 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 316274001460 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 316274001461 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 316274001462 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316274001463 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 316274001464 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 316274001465 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316274001466 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001468 active site 316274001469 phosphorylation site [posttranslational modification] 316274001470 intermolecular recognition site; other site 316274001471 dimerization interface [polypeptide binding]; other site 316274001472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274001473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 316274001474 phosphate binding site [ion binding]; other site 316274001475 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001477 active site 316274001478 phosphorylation site [posttranslational modification] 316274001479 intermolecular recognition site; other site 316274001480 dimerization interface [polypeptide binding]; other site 316274001481 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 316274001482 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 316274001483 Zn binding site [ion binding]; other site 316274001484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274001485 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 316274001486 dimer interface [polypeptide binding]; other site 316274001487 [2Fe-2S] cluster binding site [ion binding]; other site 316274001488 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001490 active site 316274001491 phosphorylation site [posttranslational modification] 316274001492 intermolecular recognition site; other site 316274001493 dimerization interface [polypeptide binding]; other site 316274001494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274001495 dimer interface [polypeptide binding]; other site 316274001496 phosphorylation site [posttranslational modification] 316274001497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001498 ATP binding site [chemical binding]; other site 316274001499 Mg2+ binding site [ion binding]; other site 316274001500 G-X-G motif; other site 316274001501 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 316274001502 Cache domain; Region: Cache_1; pfam02743 316274001503 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316274001504 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274001505 dimerization interface [polypeptide binding]; other site 316274001506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001507 GAF domain; Region: GAF; cl00853 316274001508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274001509 dimer interface [polypeptide binding]; other site 316274001510 phosphorylation site [posttranslational modification] 316274001511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001512 ATP binding site [chemical binding]; other site 316274001513 Mg2+ binding site [ion binding]; other site 316274001514 G-X-G motif; other site 316274001515 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 316274001516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274001517 Ligand Binding Site [chemical binding]; other site 316274001518 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 316274001519 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 316274001520 glutamine binding [chemical binding]; other site 316274001521 catalytic triad [active] 316274001522 Fic/DOC family; Region: Fic; cl00960 316274001523 Fic/DOC family; Region: Fic; cl00960 316274001524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274001525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274001526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274001527 DNA binding residues [nucleotide binding] 316274001528 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 316274001529 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001530 GAF domain; Region: GAF; cl00853 316274001531 Histidine kinase; Region: HisKA_3; pfam07730 316274001532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001533 ATP binding site [chemical binding]; other site 316274001534 Mg2+ binding site [ion binding]; other site 316274001535 G-X-G motif; other site 316274001536 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 316274001537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274001538 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001540 active site 316274001541 phosphorylation site [posttranslational modification] 316274001542 intermolecular recognition site; other site 316274001543 dimerization interface [polypeptide binding]; other site 316274001544 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001546 active site 316274001547 phosphorylation site [posttranslational modification] 316274001548 intermolecular recognition site; other site 316274001549 dimerization interface [polypeptide binding]; other site 316274001550 cyclase homology domain; Region: CHD; cd07302 316274001551 nucleotidyl binding site; other site 316274001552 metal binding site [ion binding]; metal-binding site 316274001553 dimer interface [polypeptide binding]; other site 316274001554 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274001555 GAF domain; Region: GAF; cl00853 316274001556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274001557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274001558 dimer interface [polypeptide binding]; other site 316274001559 phosphorylation site [posttranslational modification] 316274001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001561 ATP binding site [chemical binding]; other site 316274001562 Mg2+ binding site [ion binding]; other site 316274001563 G-X-G motif; other site 316274001564 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 316274001565 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 316274001566 active site 316274001567 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274001568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274001570 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274001571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274001572 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274001573 Vitamin K epoxide reductase family; Region: VKOR; cl01729 316274001574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001575 Coenzyme A binding pocket [chemical binding]; other site 316274001576 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 316274001577 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 316274001578 active site 316274001579 putative substrate binding region [chemical binding]; other site 316274001580 FOG: CBS domain [General function prediction only]; Region: COG0517 316274001581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a...; Region: CBS_pair_M50_like; cd04801 316274001582 Predicted membrane protein [Function unknown]; Region: COG4425 316274001583 Uncharacterized protein involved in plasmid maintenance [General function prediction only]; Region: SMP2; COG5083 316274001584 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 316274001585 structural tetrad; other site 316274001586 TRAM domain; Region: TRAM; cl01282 316274001587 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 316274001588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274001589 S-adenosylmethionine binding site [chemical binding]; other site 316274001590 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 316274001591 proposed catalytic triad [active] 316274001592 active site nucleophile [active] 316274001593 cyanophycin synthetase; Provisional; Region: PRK14016 316274001594 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274001595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274001596 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274001597 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 316274001598 Domain of unknown function (DUF814); Region: DUF814; pfam05670 316274001599 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 316274001600 catalytic site [active] 316274001601 G-X2-G-X-G-K; other site 316274001602 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 316274001603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001605 Coenzyme A binding pocket [chemical binding]; other site 316274001606 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274001607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001608 Walker A motif; other site 316274001609 ATP binding site [chemical binding]; other site 316274001610 Walker B motif; other site 316274001611 arginine finger; other site 316274001612 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274001613 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274001614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274001616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274001617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274001618 multifunctional aminopeptidase A; Provisional; Region: PRK00913 316274001619 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 316274001620 interface (dimer of trimers) [polypeptide binding]; other site 316274001621 Substrate-binding/catalytic site; other site 316274001622 Zn-binding sites [ion binding]; other site 316274001623 urocanate hydratase; Provisional; Region: PRK05414 316274001624 urocanate hydratase; Region: hutU; TIGR01228 316274001625 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316274001626 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274001627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274001628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274001629 metal binding site [ion binding]; metal-binding site 316274001630 active site 316274001631 I-site; other site 316274001632 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274001633 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 316274001634 heme-binding site [chemical binding]; other site 316274001635 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 316274001636 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274001637 active site clefts [active] 316274001638 zinc binding site [ion binding]; other site 316274001639 dimer interface [polypeptide binding]; other site 316274001640 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274001641 active site 316274001642 metal binding site [ion binding]; metal-binding site 316274001643 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 316274001644 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274001645 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 316274001646 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274001647 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274001648 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 316274001649 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 316274001650 DNA binding site [nucleotide binding] 316274001651 Int/Topo IB signature motif; other site 316274001652 active site 316274001653 catalytic residues [active] 316274001654 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274001655 Calx-beta domain; Region: Calx-beta; cl02522 316274001656 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274001657 amidase catalytic site [active] 316274001658 Zn binding residues [ion binding]; other site 316274001659 substrate binding site [chemical binding]; other site 316274001660 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 316274001661 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 316274001662 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302 316274001663 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274001664 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 316274001665 plasmid segregation protein ParM; Provisional; Region: PRK13917 316274001666 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl07038 316274001667 DNA primase; Provisional; Region: 61; PHA02540 316274001668 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 316274001669 active site 316274001670 metal binding site [ion binding]; metal-binding site 316274001671 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 316274001672 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274001673 DNA binding site [nucleotide binding] 316274001674 Int/Topo IB signature motif; other site 316274001675 active site 316274001676 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274001677 EamA-like transporter family; Region: EamA; cl01037 316274001678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001679 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 316274001680 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274001681 nudix motif; other site 316274001682 Found in ATP-dependent protease La (LON); Region: LON; cl01056 316274001683 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274001684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001685 Walker A motif; other site 316274001686 ATP binding site [chemical binding]; other site 316274001687 Walker B motif; other site 316274001688 arginine finger; other site 316274001689 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274001690 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 316274001691 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274001692 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 316274001693 Walker A/P-loop; other site 316274001694 ATP binding site [chemical binding]; other site 316274001695 Q-loop/lid; other site 316274001696 ABC transporter signature motif; other site 316274001697 Walker B; other site 316274001698 D-loop; other site 316274001699 H-loop/switch region; other site 316274001700 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316274001701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274001702 Walker A motif; other site 316274001703 ATP binding site [chemical binding]; other site 316274001704 Walker B motif; other site 316274001705 arginine finger; other site 316274001706 NAD-dependent deacetylase; Provisional; Region: PRK14138 316274001707 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 316274001708 NAD+ binding site [chemical binding]; other site 316274001709 substrate binding site [chemical binding]; other site 316274001710 Zn binding site [ion binding]; other site 316274001711 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 316274001712 putative acyl-acceptor binding pocket; other site 316274001713 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 316274001714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274001715 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274001716 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274001717 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 316274001718 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 316274001719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274001721 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 316274001722 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 316274001723 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274001724 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 316274001725 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682 316274001726 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274001727 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 316274001728 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 316274001729 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 316274001730 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 316274001731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274001732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274001733 active site 316274001734 ATP binding site [chemical binding]; other site 316274001735 substrate binding site [chemical binding]; other site 316274001736 activation loop (A-loop); other site 316274001737 Double zinc ribbon; Region: DZR; pfam12773 316274001738 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274001739 phosphopeptide binding site; other site 316274001740 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274001741 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316274001742 Peptidase family U32; Region: Peptidase_U32; cl03113 316274001743 Collagenase; Region: DUF3656; pfam12392 316274001744 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 316274001745 Peptidase family U32; Region: Peptidase_U32; cl03113 316274001746 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 316274001747 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 316274001748 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316274001749 EVE domain; Region: EVE; cl00728 316274001750 Domain of unknown function (DUF333); Region: DUF333; pfam03891 316274001751 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 316274001752 Bacitracin resistance protein BacA; Region: BacA; cl00858 316274001753 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 316274001754 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316274001755 inhibitor-cofactor binding pocket; inhibition site 316274001756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274001757 catalytic residue [active] 316274001758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274001759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001760 active site 316274001761 phosphorylation site [posttranslational modification] 316274001762 intermolecular recognition site; other site 316274001763 dimerization interface [polypeptide binding]; other site 316274001764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274001765 DNA binding residues [nucleotide binding] 316274001766 dimerization interface [polypeptide binding]; other site 316274001767 Histidine kinase; Region: HisKA_3; pfam07730 316274001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001769 ATP binding site [chemical binding]; other site 316274001770 Mg2+ binding site [ion binding]; other site 316274001771 G-X-G motif; other site 316274001772 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 316274001773 dimer interface [polypeptide binding]; other site 316274001774 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274001775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274001777 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 316274001778 putative NAD(P) binding site [chemical binding]; other site 316274001779 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274001780 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 316274001781 NADP binding site [chemical binding]; other site 316274001782 active site 316274001783 steroid binding site; other site 316274001784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274001785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274001786 Double zinc ribbon; Region: DZR; pfam12773 316274001787 Protein kinase domain; Region: Pkinase; pfam00069 316274001788 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274001789 active site 316274001790 ATP binding site [chemical binding]; other site 316274001791 substrate binding site [chemical binding]; other site 316274001792 activation loop (A-loop); other site 316274001793 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274001794 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274001795 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274001796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001797 Walker A/P-loop; other site 316274001798 ATP binding site [chemical binding]; other site 316274001799 Q-loop/lid; other site 316274001800 ABC transporter signature motif; other site 316274001801 Walker B; other site 316274001802 D-loop; other site 316274001803 H-loop/switch region; other site 316274001804 ABC transporter; Region: ABC_tran_2; pfam12848 316274001805 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274001806 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001808 active site 316274001809 phosphorylation site [posttranslational modification] 316274001810 intermolecular recognition site; other site 316274001811 dimerization interface [polypeptide binding]; other site 316274001812 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001813 GAF domain; Region: GAF; cl00853 316274001814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274001815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001816 ATP binding site [chemical binding]; other site 316274001817 Mg2+ binding site [ion binding]; other site 316274001818 G-X-G motif; other site 316274001819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274001820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001821 active site 316274001822 phosphorylation site [posttranslational modification] 316274001823 intermolecular recognition site; other site 316274001824 dimerization interface [polypeptide binding]; other site 316274001825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274001826 DNA binding site [nucleotide binding] 316274001827 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316274001828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 316274001829 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316274001830 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316274001831 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 316274001832 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316274001833 putative binding surface; other site 316274001834 active site 316274001835 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316274001836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001837 ATP binding site [chemical binding]; other site 316274001838 Mg2+ binding site [ion binding]; other site 316274001839 G-X-G motif; other site 316274001840 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316274001841 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001843 active site 316274001844 phosphorylation site [posttranslational modification] 316274001845 intermolecular recognition site; other site 316274001846 dimerization interface [polypeptide binding]; other site 316274001847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001848 active site 316274001849 phosphorylation site [posttranslational modification] 316274001850 intermolecular recognition site; other site 316274001851 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316274001852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274001853 active site 316274001854 phosphorylation site [posttranslational modification] 316274001855 intermolecular recognition site; other site 316274001856 dimerization interface [polypeptide binding]; other site 316274001857 CheB methylesterase; Region: CheB_methylest; pfam01339 316274001858 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316274001859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274001860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274001861 TPR motif; other site 316274001862 binding surface 316274001863 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274001864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274001865 binding surface 316274001866 TPR motif; other site 316274001867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274001868 binding surface 316274001869 TPR motif; other site 316274001870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274001871 binding surface 316274001872 TPR motif; other site 316274001873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274001874 binding surface 316274001875 TPR motif; other site 316274001876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274001877 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274001878 anti sigma factor interaction site; other site 316274001879 regulatory phosphorylation site [posttranslational modification]; other site 316274001880 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 316274001881 dinuclear metal binding motif [ion binding]; other site 316274001882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274001883 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274001884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274001886 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 316274001887 active site 316274001888 (T/H)XGH motif; other site 316274001889 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 316274001890 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 316274001891 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 316274001892 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316274001893 dimer interface [polypeptide binding]; other site 316274001894 active site 316274001895 CoA binding pocket [chemical binding]; other site 316274001896 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274001897 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274001898 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274001899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001900 NAD(P) binding site [chemical binding]; other site 316274001901 active site 316274001902 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274001903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001904 NAD(P) binding site [chemical binding]; other site 316274001905 active site 316274001906 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274001907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001908 NAD(P) binding site [chemical binding]; other site 316274001909 active site 316274001910 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 316274001911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274001912 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274001913 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 316274001914 Protein of unknown function (DUF322); Region: DUF322; cl00574 316274001915 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 316274001916 putative RNA binding site [nucleotide binding]; other site 316274001917 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274001918 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 316274001919 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 316274001920 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 316274001921 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316274001922 active site 316274001923 HIGH motif; other site 316274001924 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316274001925 active site 316274001926 KMSKS motif; other site 316274001927 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274001928 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274001929 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274001930 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274001931 Ligand binding site [chemical binding]; other site 316274001932 Ligand binding site [chemical binding]; other site 316274001933 Ligand binding site [chemical binding]; other site 316274001934 Putative Catalytic site [active] 316274001935 DXD motif; other site 316274001936 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 316274001937 active site 316274001938 catalytic residues [active] 316274001939 metal binding site [ion binding]; metal-binding site 316274001940 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 316274001941 G-X-X-G motif; other site 316274001942 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 316274001943 RxxxH motif; other site 316274001944 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 316274001945 Domain of unknown function DUF37; Region: DUF37; cl00506 316274001946 Ribonuclease P; Region: Ribonuclease_P; cl00457 316274001947 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 316274001948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274001949 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 316274001950 putative acyl-acceptor binding pocket; other site 316274001951 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 316274001952 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274001953 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274001954 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 316274001955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316274001956 active site 316274001957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274001958 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274001959 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 316274001960 putative active site [active] 316274001961 putative CoA binding site [chemical binding]; other site 316274001962 nudix motif; other site 316274001963 metal binding site [ion binding]; metal-binding site 316274001964 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 316274001965 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 316274001966 Walker A/P-loop; other site 316274001967 ATP binding site [chemical binding]; other site 316274001968 Q-loop/lid; other site 316274001969 ABC transporter signature motif; other site 316274001970 Walker B; other site 316274001971 D-loop; other site 316274001972 H-loop/switch region; other site 316274001973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274001974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274001975 DNA binding site [nucleotide binding] 316274001976 domain linker motif; other site 316274001977 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274001978 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274001979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274001980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001981 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274001982 putative catalytic residues [active] 316274001983 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274001984 synthase/transferase; Region: PLN02316 316274001985 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 316274001986 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274001987 RNA binding surface [nucleotide binding]; other site 316274001988 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 316274001989 active site 316274001990 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274001991 LVIVD repeat; Region: LVIVD; pfam08309 316274001992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001993 Coenzyme A binding pocket [chemical binding]; other site 316274001994 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274001995 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 316274001996 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274001997 DNA polymerase III subunit delta'; Validated; Region: PRK07940 316274001998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274001999 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002001 active site 316274002002 phosphorylation site [posttranslational modification] 316274002003 intermolecular recognition site; other site 316274002004 dimerization interface [polypeptide binding]; other site 316274002005 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274002006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274002008 putative substrate translocation pore; other site 316274002009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002010 metal binding site [ion binding]; metal-binding site 316274002011 active site 316274002012 I-site; other site 316274002013 glycerol kinase; Provisional; Region: glpK; PRK00047 316274002014 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274002015 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 316274002016 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274002017 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274002019 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 316274002020 Walker A motif; other site 316274002021 ATP binding site [chemical binding]; other site 316274002022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002023 Walker B motif; other site 316274002024 arginine finger; other site 316274002025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274002026 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274002027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002028 dimer interface [polypeptide binding]; other site 316274002029 phosphorylation site [posttranslational modification] 316274002030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002031 ATP binding site [chemical binding]; other site 316274002032 Mg2+ binding site [ion binding]; other site 316274002033 G-X-G motif; other site 316274002034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002036 active site 316274002037 phosphorylation site [posttranslational modification] 316274002038 intermolecular recognition site; other site 316274002039 dimerization interface [polypeptide binding]; other site 316274002040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274002041 DNA binding site [nucleotide binding] 316274002042 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 316274002043 Haemolysin-III related; Region: HlyIII; cl03831 316274002044 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 316274002045 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 316274002046 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316274002047 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 316274002048 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 316274002049 nucleotide binding pocket [chemical binding]; other site 316274002050 K-X-D-G motif; other site 316274002051 catalytic site [active] 316274002052 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 316274002053 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 316274002054 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 316274002055 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 316274002056 Dimer interface [polypeptide binding]; other site 316274002057 BRCT sequence motif; other site 316274002058 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 316274002059 hypothetical protein; Reviewed; Region: PRK09588 316274002060 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 316274002061 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 316274002062 putative metal binding site [ion binding]; other site 316274002063 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 316274002064 active site 316274002065 metal binding site [ion binding]; metal-binding site 316274002066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002068 active site 316274002069 phosphorylation site [posttranslational modification] 316274002070 intermolecular recognition site; other site 316274002071 dimerization interface [polypeptide binding]; other site 316274002072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274002073 DNA binding site [nucleotide binding] 316274002074 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316274002075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002076 putative active site [active] 316274002077 heme pocket [chemical binding]; other site 316274002078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002079 dimer interface [polypeptide binding]; other site 316274002080 phosphorylation site [posttranslational modification] 316274002081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002082 ATP binding site [chemical binding]; other site 316274002083 Mg2+ binding site [ion binding]; other site 316274002084 G-X-G motif; other site 316274002085 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274002086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274002087 Probable Catalytic site [active] 316274002088 metal binding site [ion binding]; metal-binding site 316274002089 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002090 Kelch motif; Region: Kelch_1; cl02701 316274002091 kelch-like protein; Provisional; Region: PHA03098 316274002092 Kelch motif; Region: Kelch_1; cl02701 316274002093 Kelch motif; Region: Kelch_1; cl02701 316274002094 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 316274002095 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 316274002096 ATP-binding site [chemical binding]; other site 316274002097 Sugar specificity; other site 316274002098 Pyrimidine base specificity; other site 316274002099 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 316274002100 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 316274002101 putative heme binding pocket [chemical binding]; other site 316274002102 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 316274002103 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 316274002104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274002105 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 316274002106 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 316274002107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274002108 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 316274002109 proposed catalytic triad [active] 316274002110 conserved cys residue [active] 316274002111 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274002112 nudix motif; other site 316274002113 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 316274002114 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 316274002115 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 316274002116 hinge; other site 316274002117 active site 316274002118 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316274002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002120 active site 316274002121 phosphorylation site [posttranslational modification] 316274002122 intermolecular recognition site; other site 316274002123 dimerization interface [polypeptide binding]; other site 316274002124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274002125 Walker A motif; other site 316274002126 ATP binding site [chemical binding]; other site 316274002127 Walker B motif; other site 316274002128 arginine finger; other site 316274002129 enoyl-CoA hydratase; Provisional; Region: PRK06688 316274002130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 316274002131 substrate binding site [chemical binding]; other site 316274002132 oxyanion hole (OAH) forming residues; other site 316274002133 trimer interface [polypeptide binding]; other site 316274002134 Domain of unknown function (DUF427); Region: DUF427; cl00998 316274002135 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 316274002136 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 316274002137 Ligand Binding Site [chemical binding]; other site 316274002138 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 316274002139 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274002140 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 316274002141 G1 box; other site 316274002142 GTP/Mg2+ binding site [chemical binding]; other site 316274002143 G2 box; other site 316274002144 Switch I region; other site 316274002145 G3 box; other site 316274002146 Switch II region; other site 316274002147 G4 box; other site 316274002148 G5 box; other site 316274002149 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 316274002150 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274002151 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 316274002152 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 316274002153 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 316274002154 PPIC-type PPIASE domain; Region: Rotamase; cl08278 316274002155 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 316274002156 dimer interface [polypeptide binding]; other site 316274002157 glycine-pyridoxal phosphate binding site [chemical binding]; other site 316274002158 active site 316274002159 folate binding site [chemical binding]; other site 316274002160 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002161 GAF domain; Region: GAF; cl00853 316274002162 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002163 GAF domain; Region: GAF; cl00853 316274002164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002165 dimer interface [polypeptide binding]; other site 316274002166 phosphorylation site [posttranslational modification] 316274002167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002168 ATP binding site [chemical binding]; other site 316274002169 Mg2+ binding site [ion binding]; other site 316274002170 G-X-G motif; other site 316274002171 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002173 active site 316274002174 phosphorylation site [posttranslational modification] 316274002175 intermolecular recognition site; other site 316274002176 dimerization interface [polypeptide binding]; other site 316274002177 enoyl-CoA hydratase; Provisional; Region: PRK05995 316274002178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 316274002179 substrate binding site [chemical binding]; other site 316274002180 oxyanion hole (OAH) forming residues; other site 316274002181 trimer interface [polypeptide binding]; other site 316274002182 Double zinc ribbon; Region: DZR; pfam12773 316274002183 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 316274002184 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 316274002185 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 316274002186 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274002187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002188 Coenzyme A binding pocket [chemical binding]; other site 316274002189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274002190 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 316274002191 putative sugar binding sites [chemical binding]; other site 316274002192 Q-X-W motif; other site 316274002193 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274002194 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 316274002195 active site 316274002196 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274002197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274002198 active site 316274002199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274002200 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274002201 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274002202 putative NADP binding site [chemical binding]; other site 316274002203 active site 316274002204 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 316274002205 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 316274002206 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 316274002207 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 316274002208 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 316274002209 Cysteine dioxygenase type I; Region: CDO_I; cl02350 316274002210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274002211 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274002212 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 316274002213 putative hydrophobic ligand binding site [chemical binding]; other site 316274002214 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316274002215 Clp protease ATP binding subunit; Region: clpC; CHL00095 316274002216 Clp amino terminal domain; Region: Clp_N; pfam02861 316274002217 Clp amino terminal domain; Region: Clp_N; pfam02861 316274002218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274002219 Walker A motif; other site 316274002220 ATP binding site [chemical binding]; other site 316274002221 Walker B motif; other site 316274002222 arginine finger; other site 316274002223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274002224 Walker A motif; other site 316274002225 ATP binding site [chemical binding]; other site 316274002226 Walker B motif; other site 316274002227 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274002228 Sulfatase; Region: Sulfatase; cl10460 316274002229 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 316274002230 GAF domain; Region: GAF; cl00853 316274002231 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 316274002232 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 316274002233 domain; Region: Glyco_hydro_2; pfam00703 316274002234 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274002235 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 316274002236 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 316274002237 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 316274002238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274002239 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 316274002240 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 316274002241 dimerization interface [polypeptide binding]; other site 316274002242 putative active cleft [active] 316274002243 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274002244 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 316274002245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274002246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274002247 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 316274002248 active site 316274002249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274002250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274002251 DNA binding site [nucleotide binding] 316274002252 domain linker motif; other site 316274002253 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274002254 ligand binding site [chemical binding]; other site 316274002255 dimerization interface [polypeptide binding]; other site 316274002256 lipoyl synthase; Provisional; Region: PRK05481 316274002257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 316274002258 AIR carboxylase; Region: AIRC; cl00310 316274002259 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 316274002260 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274002261 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 316274002262 Double zinc ribbon; Region: DZR; pfam12773 316274002263 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002264 phosphopeptide binding site; other site 316274002265 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002266 phosphopeptide binding site; other site 316274002267 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 316274002268 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274002269 Walker A/P-loop; other site 316274002270 ATP binding site [chemical binding]; other site 316274002271 Q-loop/lid; other site 316274002272 ABC transporter signature motif; other site 316274002273 Walker B; other site 316274002274 D-loop; other site 316274002275 H-loop/switch region; other site 316274002276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274002277 Double zinc ribbon; Region: DZR; pfam12773 316274002278 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274002279 Active site [active] 316274002280 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 316274002281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274002282 active site 316274002283 ATP binding site [chemical binding]; other site 316274002284 substrate binding site [chemical binding]; other site 316274002285 activation loop (A-loop); other site 316274002286 Double zinc ribbon; Region: DZR; pfam12773 316274002287 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002288 phosphopeptide binding site; other site 316274002289 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274002290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274002291 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274002292 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274002293 CoenzymeA binding site [chemical binding]; other site 316274002294 subunit interaction site [polypeptide binding]; other site 316274002295 PHB binding site; other site 316274002296 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 316274002297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002298 active site 316274002299 phosphorylation site [posttranslational modification] 316274002300 intermolecular recognition site; other site 316274002301 dimerization interface [polypeptide binding]; other site 316274002302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274002303 DNA binding site [nucleotide binding] 316274002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002305 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274002306 dimerization interface [polypeptide binding]; other site 316274002307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002308 dimer interface [polypeptide binding]; other site 316274002309 phosphorylation site [posttranslational modification] 316274002310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002311 ATP binding site [chemical binding]; other site 316274002312 Mg2+ binding site [ion binding]; other site 316274002313 G-X-G motif; other site 316274002314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 316274002315 phosphorylation site [posttranslational modification] 316274002316 intermolecular recognition site; other site 316274002317 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274002318 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 316274002319 Walker A/P-loop; other site 316274002320 ATP binding site [chemical binding]; other site 316274002321 Q-loop/lid; other site 316274002322 ABC transporter signature motif; other site 316274002323 Walker B; other site 316274002324 D-loop; other site 316274002325 H-loop/switch region; other site 316274002326 FtsX-like permease family; Region: FtsX; pfam02687 316274002327 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274002328 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274002329 YcaO-like family; Region: YcaO; cl09146 316274002330 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 316274002331 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 316274002332 NADPH bind site [chemical binding]; other site 316274002333 putative FMN binding site [chemical binding]; other site 316274002334 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 316274002335 putative FMN binding site [chemical binding]; other site 316274002336 NADPH bind site [chemical binding]; other site 316274002337 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 316274002338 active site 316274002339 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 316274002340 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 316274002341 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 316274002342 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 316274002343 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 316274002344 Walker A/P-loop; other site 316274002345 ATP binding site [chemical binding]; other site 316274002346 Q-loop/lid; other site 316274002347 ABC transporter signature motif; other site 316274002348 Walker B; other site 316274002349 D-loop; other site 316274002350 H-loop/switch region; other site 316274002351 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 316274002352 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316274002353 homodimer interface [polypeptide binding]; other site 316274002354 substrate-cofactor binding pocket; other site 316274002355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002356 catalytic residue [active] 316274002357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274002358 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 316274002359 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 316274002360 G1 box; other site 316274002361 GTP/Mg2+ binding site [chemical binding]; other site 316274002362 G2 box; other site 316274002363 Switch I region; other site 316274002364 G3 box; other site 316274002365 Switch II region; other site 316274002366 G4 box; other site 316274002367 G5 box; other site 316274002368 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274002369 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274002370 Kelch motif; Region: Kelch_1; cl02701 316274002371 kelch-like protein; Provisional; Region: PHA03098 316274002372 Kelch motif; Region: Kelch_1; cl02701 316274002373 Kelch motif; Region: Kelch_1; cl02701 316274002374 kelch-like protein; Provisional; Region: PHA03098 316274002375 Kelch motif; Region: Kelch_1; cl02701 316274002376 Kelch motif; Region: Kelch_1; cl02701 316274002377 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 316274002378 putative dimer interface [polypeptide binding]; other site 316274002379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002380 GAF domain; Region: GAF; cl00853 316274002381 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274002382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002383 putative active site [active] 316274002384 heme pocket [chemical binding]; other site 316274002385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002386 dimer interface [polypeptide binding]; other site 316274002387 phosphorylation site [posttranslational modification] 316274002388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002389 ATP binding site [chemical binding]; other site 316274002390 Mg2+ binding site [ion binding]; other site 316274002391 G-X-G motif; other site 316274002392 Domain of unknown function DUF11; Region: DUF11; cl03172 316274002393 CHASE2 domain; Region: CHASE2; cl01732 316274002394 cyclase homology domain; Region: CHD; cd07302 316274002395 nucleotidyl binding site; other site 316274002396 metal binding site [ion binding]; metal-binding site 316274002397 dimer interface [polypeptide binding]; other site 316274002398 FecR protein; Region: FecR; pfam04773 316274002399 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 316274002400 putative peptidoglycan binding site; other site 316274002401 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274002402 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 316274002403 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274002404 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274002405 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 316274002406 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 316274002407 active site 316274002408 substrate binding site [chemical binding]; other site 316274002409 cosubstrate binding site; other site 316274002410 catalytic site [active] 316274002411 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 316274002412 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316274002413 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274002414 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316274002415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274002417 binding surface 316274002418 TPR motif; other site 316274002419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274002420 DNA binding residues [nucleotide binding] 316274002421 dimerization interface [polypeptide binding]; other site 316274002422 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274002423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274002424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002425 Walker A/P-loop; other site 316274002426 ATP binding site [chemical binding]; other site 316274002427 Q-loop/lid; other site 316274002428 ABC transporter signature motif; other site 316274002429 Walker B; other site 316274002430 D-loop; other site 316274002431 H-loop/switch region; other site 316274002432 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274002433 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274002434 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 316274002435 Walker A/P-loop; other site 316274002436 ATP binding site [chemical binding]; other site 316274002437 Q-loop/lid; other site 316274002438 ABC transporter signature motif; other site 316274002439 Walker B; other site 316274002440 D-loop; other site 316274002441 H-loop/switch region; other site 316274002442 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 316274002443 active site 316274002444 dimerization interface [polypeptide binding]; other site 316274002445 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 316274002446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274002447 threonine dehydratase; Provisional; Region: PRK08198 316274002448 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 316274002449 tetramer interface [polypeptide binding]; other site 316274002450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002451 catalytic residue [active] 316274002452 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 316274002453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274002454 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 316274002455 hydrophobic ligand binding site; other site 316274002456 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 316274002457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274002458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274002459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274002460 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274002461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274002462 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274002463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274002464 active site 316274002465 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274002466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274002467 active site 316274002468 SCP-2 sterol transfer family; Region: SCP2; cl01225 316274002469 OsmC-like protein; Region: OsmC; cl00767 316274002470 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 316274002471 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316274002472 active site 316274002473 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 316274002474 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002476 active site 316274002477 phosphorylation site [posttranslational modification] 316274002478 intermolecular recognition site; other site 316274002479 dimerization interface [polypeptide binding]; other site 316274002480 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 316274002481 active site 316274002482 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274002483 Stage II sporulation protein; Region: SpoIID; cl07201 316274002484 Stage II sporulation protein; Region: SpoIID; cl07201 316274002485 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274002486 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274002487 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 316274002488 Translin family; Region: Translin; cl00957 316274002489 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 316274002490 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 316274002491 hinge; other site 316274002492 active site 316274002493 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 316274002494 short chain dehydrogenase; Provisional; Region: PRK07677 316274002495 NAD(P) binding site [chemical binding]; other site 316274002496 substrate binding site [chemical binding]; other site 316274002497 homotetramer interface [polypeptide binding]; other site 316274002498 active site 316274002499 homodimer interface [polypeptide binding]; other site 316274002500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002502 Cytochrome P450; Region: p450; cl12078 316274002503 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 316274002504 classical (c) SDRs; Region: SDR_c; cd05233 316274002505 NAD(P) binding site [chemical binding]; other site 316274002506 active site 316274002507 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274002508 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274002509 OsmC-like protein; Region: OsmC; cl00767 316274002510 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274002511 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274002512 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274002513 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 316274002514 active site 316274002515 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 316274002516 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 316274002517 Cation efflux family; Region: Cation_efflux; cl00316 316274002518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002519 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274002520 Histidine kinase; Region: HisKA_3; pfam07730 316274002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002522 ATP binding site [chemical binding]; other site 316274002523 Mg2+ binding site [ion binding]; other site 316274002524 G-X-G motif; other site 316274002525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002527 active site 316274002528 phosphorylation site [posttranslational modification] 316274002529 intermolecular recognition site; other site 316274002530 dimerization interface [polypeptide binding]; other site 316274002531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274002532 DNA binding residues [nucleotide binding] 316274002533 dimerization interface [polypeptide binding]; other site 316274002534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002535 metabolite-proton symporter; Region: 2A0106; TIGR00883 316274002536 putative substrate translocation pore; other site 316274002537 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002539 active site 316274002540 phosphorylation site [posttranslational modification] 316274002541 intermolecular recognition site; other site 316274002542 dimerization interface [polypeptide binding]; other site 316274002543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274002544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274002545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002546 metal binding site [ion binding]; metal-binding site 316274002547 active site 316274002548 I-site; other site 316274002549 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274002550 GAF domain; Region: GAF; cl00853 316274002551 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 316274002552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002553 putative active site [active] 316274002554 heme pocket [chemical binding]; other site 316274002555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274002556 Histidine kinase; Region: HisKA_2; cl06527 316274002557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002558 ATP binding site [chemical binding]; other site 316274002559 Mg2+ binding site [ion binding]; other site 316274002560 G-X-G motif; other site 316274002561 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274002562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 316274002563 Double zinc ribbon; Region: DZR; pfam12773 316274002564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274002565 active site 316274002566 ATP binding site [chemical binding]; other site 316274002567 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274002568 substrate binding site [chemical binding]; other site 316274002569 activation loop (A-loop); other site 316274002570 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002571 putative diguanylate cyclase; Provisional; Region: PRK09776 316274002572 probable methyltransferase; Region: TIGR03438 316274002573 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 316274002574 TIGR03440 family protein; Region: unchr_TIGR03440 316274002575 DinB superfamily; Region: DinB_2; cl00986 316274002576 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274002577 acetyl-CoA synthetase; Provisional; Region: PRK00174 316274002578 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 316274002579 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274002580 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 316274002581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 316274002582 HemN C-terminal region; Region: HemN_C; pfam06969 316274002583 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274002584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274002585 putative active site [active] 316274002586 putative metal binding site [ion binding]; other site 316274002587 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316274002588 active site 316274002589 substrate binding site [chemical binding]; other site 316274002590 catalytic site [active] 316274002591 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274002592 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 316274002593 putative deacylase active site [active] 316274002594 NlpC/P60 family; Region: NLPC_P60; cl11438 316274002595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274002596 DNA binding residues [nucleotide binding] 316274002597 dimerization interface [polypeptide binding]; other site 316274002598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274002599 DNA binding residues [nucleotide binding] 316274002600 dimerization interface [polypeptide binding]; other site 316274002601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274002602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274002603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274002604 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274002605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274002606 non-specific DNA binding site [nucleotide binding]; other site 316274002607 salt bridge; other site 316274002608 sequence-specific DNA binding site [nucleotide binding]; other site 316274002609 Domain of unknown function (DUF955); Region: DUF955; cl01076 316274002610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002612 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274002613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002614 putative substrate translocation pore; other site 316274002615 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 316274002616 malate synthase A; Region: malate_syn_A; TIGR01344 316274002617 active site 316274002618 isocitrate lyase; Provisional; Region: PRK06498 316274002619 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 316274002620 tetramer interface [polypeptide binding]; other site 316274002621 active site 316274002622 Mg2+/Mn2+ binding site [ion binding]; other site 316274002623 shikimate kinase; Reviewed; Region: aroK; PRK00131 316274002624 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 316274002625 ADP binding site [chemical binding]; other site 316274002626 magnesium binding site [ion binding]; other site 316274002627 putative shikimate binding site; other site 316274002628 M28, and M42; Region: Zinc_peptidase_like; cl14876 316274002629 M28, and M42; Region: Zinc_peptidase_like; cl14876 316274002630 metal binding site [ion binding]; metal-binding site 316274002631 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316274002632 active site 316274002633 ATP binding site [chemical binding]; other site 316274002634 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316274002635 substrate binding site [chemical binding]; other site 316274002636 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274002637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274002638 putative active site [active] 316274002639 putative metal binding site [ion binding]; other site 316274002640 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 316274002641 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 316274002642 Cl- selectivity filter; other site 316274002643 Cl- binding residues [ion binding]; other site 316274002644 pore gating glutamate residue; other site 316274002645 dimer interface [polypeptide binding]; other site 316274002646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274002647 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 316274002648 putative ADP-binding pocket [chemical binding]; other site 316274002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274002650 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316274002651 putative ribose interaction site [chemical binding]; other site 316274002652 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 316274002653 putative ADP binding site [chemical binding]; other site 316274002654 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316274002655 putative active site [active] 316274002656 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 316274002657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274002658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274002659 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002660 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316274002661 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 316274002662 Walker A/P-loop; other site 316274002663 ATP binding site [chemical binding]; other site 316274002664 Q-loop/lid; other site 316274002665 ABC transporter signature motif; other site 316274002666 Walker B; other site 316274002667 D-loop; other site 316274002668 H-loop/switch region; other site 316274002669 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274002670 Protein of unknown function (DUF541); Region: SIMPL; cl01077 316274002671 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 316274002672 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 316274002673 tetramer interface [polypeptide binding]; other site 316274002674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002675 catalytic residue [active] 316274002676 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274002677 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 316274002678 active site 316274002679 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 316274002680 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 316274002681 dimer interface [polypeptide binding]; other site 316274002682 active site 316274002683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274002684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002685 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 316274002686 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 316274002687 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 316274002688 catalytic residues [active] 316274002689 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 316274002690 ATP-NAD kinase; Region: NAD_kinase; pfam01513 316274002691 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 316274002692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274002693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274002694 binding surface 316274002695 TPR motif; other site 316274002696 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 316274002697 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 316274002698 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316274002699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274002700 FeS/SAM binding site; other site 316274002701 TRAM domain; Region: TRAM; cl01282 316274002702 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002704 active site 316274002705 phosphorylation site [posttranslational modification] 316274002706 intermolecular recognition site; other site 316274002707 dimerization interface [polypeptide binding]; other site 316274002708 cobyric acid synthase; Provisional; Region: PRK00784 316274002709 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274002710 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274002711 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316274002712 catalytic triad [active] 316274002713 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 316274002714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274002715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002716 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274002717 catalytic residue [active] 316274002718 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 316274002719 homotrimer interface [polypeptide binding]; other site 316274002720 Walker A motif; other site 316274002721 GTP binding site [chemical binding]; other site 316274002722 Walker B motif; other site 316274002723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274002724 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274002725 Walker A/P-loop; other site 316274002726 ATP binding site [chemical binding]; other site 316274002727 Q-loop/lid; other site 316274002728 ABC transporter signature motif; other site 316274002729 Walker B; other site 316274002730 D-loop; other site 316274002731 H-loop/switch region; other site 316274002732 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274002733 ABC-ATPase subunit interface; other site 316274002734 dimer interface [polypeptide binding]; other site 316274002735 putative PBP binding regions; other site 316274002736 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316274002737 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 316274002738 cobalamin binding residues [chemical binding]; other site 316274002739 putative BtuC binding residues; other site 316274002740 dimer interface [polypeptide binding]; other site 316274002741 CobD/Cbib protein; Region: CobD_Cbib; cl00561 316274002742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274002743 S-adenosylmethionine binding site [chemical binding]; other site 316274002744 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 316274002745 dimer interface [polypeptide binding]; other site 316274002746 [2Fe-2S] cluster binding site [ion binding]; other site 316274002747 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 316274002748 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 316274002749 dimer interface [polypeptide binding]; other site 316274002750 [2Fe-2S] cluster binding site [ion binding]; other site 316274002751 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 316274002752 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 316274002753 homodimer interface [polypeptide binding]; other site 316274002754 Walker A motif; other site 316274002755 ATP binding site [chemical binding]; other site 316274002756 hydroxycobalamin binding site [chemical binding]; other site 316274002757 Walker B motif; other site 316274002758 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 316274002759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002760 Walker A/P-loop; other site 316274002761 ATP binding site [chemical binding]; other site 316274002762 Q-loop/lid; other site 316274002763 ABC transporter signature motif; other site 316274002764 Walker B; other site 316274002765 D-loop; other site 316274002766 H-loop/switch region; other site 316274002767 TOBE domain; Region: TOBE_2; cl01440 316274002768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274002769 dimer interface [polypeptide binding]; other site 316274002770 conserved gate region; other site 316274002771 putative PBP binding loops; other site 316274002772 ABC-ATPase subunit interface; other site 316274002773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274002774 dimer interface [polypeptide binding]; other site 316274002775 conserved gate region; other site 316274002776 putative PBP binding loops; other site 316274002777 ABC-ATPase subunit interface; other site 316274002778 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 316274002779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274002780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274002781 active site 316274002782 nucleotide binding site [chemical binding]; other site 316274002783 HIGH motif; other site 316274002784 KMSKS motif; other site 316274002785 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316274002786 putative ribose interaction site [chemical binding]; other site 316274002787 putative ADP binding site [chemical binding]; other site 316274002788 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274002789 classical (c) SDRs; Region: SDR_c; cd05233 316274002790 NAD(P) binding site [chemical binding]; other site 316274002791 active site 316274002792 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 316274002793 active site 316274002794 catalytic residues [active] 316274002795 Sugar fermentation stimulation protein; Region: SfsA; cl00647 316274002796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274002797 dimerization interface [polypeptide binding]; other site 316274002798 putative DNA binding site [nucleotide binding]; other site 316274002799 putative Zn2+ binding site [ion binding]; other site 316274002800 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 316274002801 putative hydrophobic ligand binding site [chemical binding]; other site 316274002802 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 316274002803 PSP1 C-terminal conserved region; Region: PSP1; cl00770 316274002804 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002805 phosphopeptide binding site; other site 316274002806 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002807 GAF domain; Region: GAF; cl00853 316274002808 cyclase homology domain; Region: CHD; cd07302 316274002809 nucleotidyl binding site; other site 316274002810 metal binding site [ion binding]; metal-binding site 316274002811 dimer interface [polypeptide binding]; other site 316274002812 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274002813 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274002814 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 316274002815 Multicopper oxidase; Region: Cu-oxidase; cl14658 316274002816 Multicopper oxidase; Region: Cu-oxidase; cl14658 316274002817 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002819 active site 316274002820 phosphorylation site [posttranslational modification] 316274002821 intermolecular recognition site; other site 316274002822 dimerization interface [polypeptide binding]; other site 316274002823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274002824 Ligand Binding Site [chemical binding]; other site 316274002825 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274002826 Ligand Binding Site [chemical binding]; other site 316274002827 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 316274002828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002829 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 316274002830 putative L-serine binding site [chemical binding]; other site 316274002831 yiaA/B two helix domain; Region: YiaAB; cl01759 316274002832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002833 NAD(P) binding site [chemical binding]; other site 316274002834 active site 316274002835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002837 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 316274002838 putative peptidoglycan binding site; other site 316274002839 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 316274002840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274002841 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 316274002842 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 316274002843 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 316274002844 homodimer; other site 316274002845 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002847 active site 316274002848 phosphorylation site [posttranslational modification] 316274002849 intermolecular recognition site; other site 316274002850 dimerization interface [polypeptide binding]; other site 316274002851 CHASE4 domain; Region: CHASE4; cl01308 316274002852 biofilm formation regulator HmsP; Provisional; Region: PRK11829 316274002853 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274002854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274002855 dimerization interface [polypeptide binding]; other site 316274002856 putative DNA binding site [nucleotide binding]; other site 316274002857 putative Zn2+ binding site [ion binding]; other site 316274002858 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002859 Active site [active] 316274002860 homoserine dehydrogenase family protein; Region: PLN02700 316274002861 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 316274002862 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274002863 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274002864 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 316274002865 Walker A/P-loop; other site 316274002866 ATP binding site [chemical binding]; other site 316274002867 Q-loop/lid; other site 316274002868 ABC transporter signature motif; other site 316274002869 Walker B; other site 316274002870 D-loop; other site 316274002871 H-loop/switch region; other site 316274002872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274002874 active site 316274002875 phosphorylation site [posttranslational modification] 316274002876 intermolecular recognition site; other site 316274002877 dimerization interface [polypeptide binding]; other site 316274002878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274002879 DNA binding residues [nucleotide binding] 316274002880 dimerization interface [polypeptide binding]; other site 316274002881 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 316274002882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002883 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274002884 dimerization interface [polypeptide binding]; other site 316274002885 Histidine kinase; Region: HisKA_3; pfam07730 316274002886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002887 ATP binding site [chemical binding]; other site 316274002888 Mg2+ binding site [ion binding]; other site 316274002889 G-X-G motif; other site 316274002890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274002891 FeS/SAM binding site; other site 316274002892 PAS domain S-box; Region: sensory_box; TIGR00229 316274002893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002894 metal binding site [ion binding]; metal-binding site 316274002895 active site 316274002896 I-site; other site 316274002897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274002898 PspC domain; Region: PspC; cl00864 316274002899 NlpC/P60 family; Region: NLPC_P60; cl11438 316274002900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002901 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274002902 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274002903 active site 316274002904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274002905 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274002906 metal ion-dependent adhesion site (MIDAS); other site 316274002907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 316274002908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274002909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274002910 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002911 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274002913 S-adenosylmethionine binding site [chemical binding]; other site 316274002914 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274002915 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 316274002916 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 316274002917 G1 box; other site 316274002918 putative GEF interaction site [polypeptide binding]; other site 316274002919 GTP/Mg2+ binding site [chemical binding]; other site 316274002920 Switch I region; other site 316274002921 G2 box; other site 316274002922 G3 box; other site 316274002923 Switch II region; other site 316274002924 G4 box; other site 316274002925 G5 box; other site 316274002926 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 316274002927 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 316274002928 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 316274002929 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 316274002930 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 316274002931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 316274002932 binding surface 316274002933 TPR motif; other site 316274002934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274002935 DinB superfamily; Region: DinB_2; cl00986 316274002936 TIGR03085 family protein; Region: TIGR03085 316274002937 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274002938 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274002939 methionine aminopeptidase; Reviewed; Region: PRK07281 316274002940 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316274002941 active site 316274002942 methionine aminopeptidase; Reviewed; Region: PRK07281 316274002943 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316274002944 active site 316274002945 lipoprotein signal peptidase; Provisional; Region: PRK14787 316274002946 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 316274002947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002948 metal binding site [ion binding]; metal-binding site 316274002949 active site 316274002950 I-site; other site 316274002951 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274002952 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274002953 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274002954 active site 316274002955 substrate binding site [chemical binding]; other site 316274002956 Mg2+ binding site [ion binding]; other site 316274002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002958 putative substrate translocation pore; other site 316274002959 sugar efflux transporter; Region: 2A0120; TIGR00899 316274002960 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 316274002961 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 316274002962 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 316274002963 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316274002964 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316274002965 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274002966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274002967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274002968 dimer interface [polypeptide binding]; other site 316274002969 phosphorylation site [posttranslational modification] 316274002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002971 ATP binding site [chemical binding]; other site 316274002972 Mg2+ binding site [ion binding]; other site 316274002973 G-X-G motif; other site 316274002974 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 316274002975 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274002976 active site 316274002977 nucleophile elbow; other site 316274002978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274002979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 316274002980 TROVE domain; Region: TROVE; pfam05731 316274002981 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274002982 metal ion-dependent adhesion site (MIDAS); other site 316274002983 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 316274002984 putative homodimer interface [polypeptide binding]; other site 316274002985 putative active site pocket [active] 316274002986 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 316274002987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274002988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274002990 dimer interface [polypeptide binding]; other site 316274002991 conserved gate region; other site 316274002992 putative PBP binding loops; other site 316274002993 ABC-ATPase subunit interface; other site 316274002994 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274002996 dimer interface [polypeptide binding]; other site 316274002997 conserved gate region; other site 316274002998 putative PBP binding loops; other site 316274002999 ABC-ATPase subunit interface; other site 316274003000 trehalose synthase; Region: treS_nterm; TIGR02456 316274003001 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274003002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003003 Coenzyme A binding pocket [chemical binding]; other site 316274003004 BioY family; Region: BioY; cl00560 316274003005 Protein of unknown function (DUF779); Region: DUF779; cl01432 316274003006 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 316274003007 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274003008 NAD(P) binding site [chemical binding]; other site 316274003009 catalytic residues [active] 316274003010 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003012 active site 316274003013 phosphorylation site [posttranslational modification] 316274003014 intermolecular recognition site; other site 316274003015 dimerization interface [polypeptide binding]; other site 316274003016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274003017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274003018 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274003019 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 316274003020 active site 316274003021 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 316274003022 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316274003023 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 316274003024 active site 316274003025 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 316274003026 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274003027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274003028 active site 316274003029 catalytic tetrad [active] 316274003030 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 316274003031 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316274003032 dimer interface [polypeptide binding]; other site 316274003033 active site 316274003034 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316274003035 dimer interface [polypeptide binding]; other site 316274003036 active site 316274003037 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 316274003038 active site 316274003039 dimer interface [polypeptide binding]; other site 316274003040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003041 Coenzyme A binding pocket [chemical binding]; other site 316274003042 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 316274003043 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 316274003044 putative active site [active] 316274003045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274003046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003047 dimer interface [polypeptide binding]; other site 316274003048 conserved gate region; other site 316274003049 putative PBP binding loops; other site 316274003050 ABC-ATPase subunit interface; other site 316274003051 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 316274003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003053 dimer interface [polypeptide binding]; other site 316274003054 conserved gate region; other site 316274003055 putative PBP binding loops; other site 316274003056 ABC-ATPase subunit interface; other site 316274003057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274003058 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274003059 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274003060 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274003061 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274003062 Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase (CP) T (CPT)-like proteins. This group belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-...; Region: M14_CPT_like; cd06226 316274003063 putative active site [active] 316274003064 Zn-binding site [ion binding]; other site 316274003065 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 316274003066 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274003067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003068 Coenzyme A binding pocket [chemical binding]; other site 316274003069 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274003070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274003071 active site 316274003072 metal binding site [ion binding]; metal-binding site 316274003073 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274003074 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 316274003075 active site 316274003076 catalytic triad [active] 316274003077 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274003078 phosphopeptide binding site; other site 316274003079 Protein of unknown function (DUF456); Region: DUF456; cl01069 316274003080 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 316274003081 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 316274003082 Uncharacterized conserved protein [Function unknown]; Region: COG1306 316274003083 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 316274003084 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 316274003085 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 316274003086 DNA binding site [nucleotide binding] 316274003087 catalytic residue [active] 316274003088 H2TH interface [polypeptide binding]; other site 316274003089 putative catalytic residues [active] 316274003090 turnover-facilitating residue; other site 316274003091 intercalation triad [nucleotide binding]; other site 316274003092 8OG recognition residue [nucleotide binding]; other site 316274003093 putative reading head residues; other site 316274003094 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316274003095 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316274003096 UGMP family protein; Validated; Region: PRK09604 316274003097 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 316274003098 Esterase/lipase [General function prediction only]; Region: COG1647 316274003099 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 316274003100 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274003101 putative active site [active] 316274003102 putative metal binding site [ion binding]; other site 316274003103 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 316274003104 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 316274003105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 316274003106 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 316274003107 active site 316274003108 DinB superfamily; Region: DinB_2; cl00986 316274003109 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 316274003110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 316274003111 substrate binding site [chemical binding]; other site 316274003112 oxyanion hole (OAH) forming residues; other site 316274003113 trimer interface [polypeptide binding]; other site 316274003114 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 316274003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274003116 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274003117 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 316274003118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274003120 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 316274003121 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 316274003122 putative NADP binding site [chemical binding]; other site 316274003123 putative substrate binding site [chemical binding]; other site 316274003124 active site 316274003125 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 316274003126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274003127 CHAT domain; Region: CHAT; cl02083 316274003128 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316274003129 GTP binding site [chemical binding]; other site 316274003130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274003131 Protein of unknown function (DUF422); Region: DUF422; cl00991 316274003132 cyclase homology domain; Region: CHD; cd07302 316274003133 nucleotidyl binding site; other site 316274003134 metal binding site [ion binding]; metal-binding site 316274003135 dimer interface [polypeptide binding]; other site 316274003136 cyclase homology domain; Region: CHD; cd07302 316274003137 nucleotidyl binding site; other site 316274003138 metal binding site [ion binding]; metal-binding site 316274003139 dimer interface [polypeptide binding]; other site 316274003140 Predicted ATPase [General function prediction only]; Region: COG3899 316274003141 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003143 active site 316274003144 phosphorylation site [posttranslational modification] 316274003145 intermolecular recognition site; other site 316274003146 dimerization interface [polypeptide binding]; other site 316274003147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003148 Coenzyme A binding pocket [chemical binding]; other site 316274003149 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 316274003150 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 316274003151 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274003152 dimerization interface [polypeptide binding]; other site 316274003153 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003154 GAF domain; Region: GAF; cl00853 316274003155 PAS domain S-box; Region: sensory_box; TIGR00229 316274003156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003157 putative active site [active] 316274003158 heme pocket [chemical binding]; other site 316274003159 PAS domain S-box; Region: sensory_box; TIGR00229 316274003160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003161 putative active site [active] 316274003162 heme pocket [chemical binding]; other site 316274003163 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003164 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003165 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274003166 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 316274003167 GAF domain; Region: GAF; cl00853 316274003168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274003169 dimer interface [polypeptide binding]; other site 316274003170 phosphorylation site [posttranslational modification] 316274003171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003172 ATP binding site [chemical binding]; other site 316274003173 Mg2+ binding site [ion binding]; other site 316274003174 G-X-G motif; other site 316274003175 threonine synthase; Validated; Region: PRK06260 316274003176 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 316274003177 homodimer interface [polypeptide binding]; other site 316274003178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003179 catalytic residue [active] 316274003180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003182 active site 316274003183 phosphorylation site [posttranslational modification] 316274003184 intermolecular recognition site; other site 316274003185 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003187 active site 316274003188 phosphorylation site [posttranslational modification] 316274003189 intermolecular recognition site; other site 316274003190 dimerization interface [polypeptide binding]; other site 316274003191 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003193 active site 316274003194 phosphorylation site [posttranslational modification] 316274003195 intermolecular recognition site; other site 316274003196 dimerization interface [polypeptide binding]; other site 316274003197 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274003198 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 316274003199 active site 316274003200 Substrate binding site [chemical binding]; other site 316274003201 Mg++ binding site [ion binding]; other site 316274003202 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274003203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274003204 Walker A motif; other site 316274003205 ATP binding site [chemical binding]; other site 316274003206 Walker B motif; other site 316274003207 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274003208 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 316274003209 peptide binding site [polypeptide binding]; other site 316274003210 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003212 dimer interface [polypeptide binding]; other site 316274003213 conserved gate region; other site 316274003214 putative PBP binding loops; other site 316274003215 ABC-ATPase subunit interface; other site 316274003216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274003217 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274003218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003219 dimer interface [polypeptide binding]; other site 316274003220 conserved gate region; other site 316274003221 putative PBP binding loops; other site 316274003222 ABC-ATPase subunit interface; other site 316274003223 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274003224 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274003225 Walker A/P-loop; other site 316274003226 ATP binding site [chemical binding]; other site 316274003227 Q-loop/lid; other site 316274003228 ABC transporter signature motif; other site 316274003229 Walker B; other site 316274003230 D-loop; other site 316274003231 H-loop/switch region; other site 316274003232 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274003233 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 316274003234 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274003235 Walker A/P-loop; other site 316274003236 ATP binding site [chemical binding]; other site 316274003237 Q-loop/lid; other site 316274003238 ABC transporter signature motif; other site 316274003239 Walker B; other site 316274003240 D-loop; other site 316274003241 H-loop/switch region; other site 316274003242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274003243 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 316274003244 dimerization interface [polypeptide binding]; other site 316274003245 putative ATP binding site [chemical binding]; other site 316274003246 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274003247 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 316274003248 Arginase family; Region: Arginase; cl00306 316274003249 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274003250 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003251 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274003252 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003253 polycystin cation channel protein; Region: PCC; TIGR00864 316274003254 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 316274003255 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003256 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274003257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274003258 Walker A/P-loop; other site 316274003259 ATP binding site [chemical binding]; other site 316274003260 Q-loop/lid; other site 316274003261 ABC transporter signature motif; other site 316274003262 Walker B; other site 316274003263 D-loop; other site 316274003264 H-loop/switch region; other site 316274003265 TOBE domain; Region: TOBE_2; cl01440 316274003266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003267 dimer interface [polypeptide binding]; other site 316274003268 conserved gate region; other site 316274003269 putative PBP binding loops; other site 316274003270 ABC-ATPase subunit interface; other site 316274003271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274003272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003273 dimer interface [polypeptide binding]; other site 316274003274 conserved gate region; other site 316274003275 putative PBP binding loops; other site 316274003276 ABC-ATPase subunit interface; other site 316274003277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274003278 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 316274003279 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316274003280 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 316274003281 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316274003282 NAD binding site [chemical binding]; other site 316274003283 substrate binding site [chemical binding]; other site 316274003284 homodimer interface [polypeptide binding]; other site 316274003285 active site 316274003286 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316274003287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274003288 DNA-binding site [nucleotide binding]; DNA binding site 316274003289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274003290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003291 homodimer interface [polypeptide binding]; other site 316274003292 catalytic residue [active] 316274003293 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 316274003294 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274003295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274003296 catalytic residue [active] 316274003297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274003298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274003299 DNA binding site [nucleotide binding] 316274003300 domain linker motif; other site 316274003301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274003302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274003303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003305 dimer interface [polypeptide binding]; other site 316274003306 conserved gate region; other site 316274003307 putative PBP binding loops; other site 316274003308 ABC-ATPase subunit interface; other site 316274003309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274003310 dimer interface [polypeptide binding]; other site 316274003311 conserved gate region; other site 316274003312 putative PBP binding loops; other site 316274003313 ABC-ATPase subunit interface; other site 316274003314 putative alpha-glucosidase; Provisional; Region: PRK10658 316274003315 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 316274003316 active site 316274003317 homotrimer interface [polypeptide binding]; other site 316274003318 catalytic site [active] 316274003319 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 316274003320 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 316274003321 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 316274003322 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274003323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274003324 active site 316274003325 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274003326 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274003327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003328 putative substrate translocation pore; other site 316274003329 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 316274003330 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 316274003331 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 316274003332 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274003333 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274003334 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274003335 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274003336 TLC ATP/ADP transporter; Region: TLC; cl03940 316274003337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003338 Coenzyme A binding pocket [chemical binding]; other site 316274003339 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 316274003340 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274003341 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274003342 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003343 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 316274003344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 316274003345 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 316274003346 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 316274003347 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 316274003348 Na(+)-translocating NADH-quinone reductase subunit A (NQRA); Region: NQRA; pfam05896 316274003349 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003351 active site 316274003352 phosphorylation site [posttranslational modification] 316274003353 intermolecular recognition site; other site 316274003354 dimerization interface [polypeptide binding]; other site 316274003355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274003356 dimer interface [polypeptide binding]; other site 316274003357 phosphorylation site [posttranslational modification] 316274003358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003359 ATP binding site [chemical binding]; other site 316274003360 Mg2+ binding site [ion binding]; other site 316274003361 G-X-G motif; other site 316274003362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003363 active site 316274003364 phosphorylation site [posttranslational modification] 316274003365 intermolecular recognition site; other site 316274003366 Uncharacterized conserved protein [Function unknown]; Region: COG3287 316274003367 FIST N domain; Region: FIST; pfam08495 316274003368 FIST C domain; Region: FIST_C; pfam10442 316274003369 GAF domain; Region: GAF; cl00853 316274003370 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003372 active site 316274003373 phosphorylation site [posttranslational modification] 316274003374 intermolecular recognition site; other site 316274003375 dimerization interface [polypeptide binding]; other site 316274003376 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274003377 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 316274003378 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 316274003379 active site 316274003380 DNA binding site [nucleotide binding] 316274003381 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 316274003382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274003383 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274003384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274003385 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 316274003386 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 316274003387 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274003388 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274003389 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 316274003390 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274003391 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316274003392 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 316274003393 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 316274003394 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274003395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274003396 ATP binding site [chemical binding]; other site 316274003397 putative Mg++ binding site [ion binding]; other site 316274003398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274003399 nucleotide binding region [chemical binding]; other site 316274003400 ATP-binding site [chemical binding]; other site 316274003401 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 316274003402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274003403 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 316274003404 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 316274003405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274003406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274003407 non-specific DNA binding site [nucleotide binding]; other site 316274003408 salt bridge; other site 316274003409 sequence-specific DNA binding site [nucleotide binding]; other site 316274003410 Quinolinate synthetase A protein; Region: NadA; cl00420 316274003411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274003412 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274003413 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 316274003414 Multicopper oxidase; Region: Cu-oxidase; cl14658 316274003415 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316274003416 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316274003417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274003418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274003419 ligand binding site [chemical binding]; other site 316274003420 flexible hinge region; other site 316274003421 Cupin domain; Region: Cupin_2; cl09118 316274003422 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274003423 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274003424 catalytic site [active] 316274003425 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 316274003426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274003427 ATP binding site [chemical binding]; other site 316274003428 putative Mg++ binding site [ion binding]; other site 316274003429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274003430 nucleotide binding region [chemical binding]; other site 316274003431 ATP-binding site [chemical binding]; other site 316274003432 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 316274003433 Lumazine binding domain; Region: Lum_binding; pfam00677 316274003434 Lumazine binding domain; Region: Lum_binding; pfam00677 316274003435 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274003436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274003437 S-adenosylmethionine binding site [chemical binding]; other site 316274003438 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 316274003439 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 316274003440 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 316274003441 dimerization interface [polypeptide binding]; other site 316274003442 active site 316274003443 hypothetical protein; Reviewed; Region: PRK00024 316274003444 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316274003445 MPN+ (JAMM) motif; other site 316274003446 Zinc-binding site [ion binding]; other site 316274003447 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003448 GAF domain; Region: GAF; cl00853 316274003449 Histidine kinase; Region: HisKA_3; pfam07730 316274003450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274003451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274003452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003453 active site 316274003454 phosphorylation site [posttranslational modification] 316274003455 intermolecular recognition site; other site 316274003456 dimerization interface [polypeptide binding]; other site 316274003457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274003458 DNA binding residues [nucleotide binding] 316274003459 dimerization interface [polypeptide binding]; other site 316274003460 hypothetical protein; Provisional; Region: PRK11568 316274003461 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 316274003462 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 316274003463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274003464 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 316274003465 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 316274003466 trimer interface [polypeptide binding]; other site 316274003467 active site 316274003468 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003470 active site 316274003471 phosphorylation site [posttranslational modification] 316274003472 intermolecular recognition site; other site 316274003473 dimerization interface [polypeptide binding]; other site 316274003474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274003475 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003476 PAS domain S-box; Region: sensory_box; TIGR00229 316274003477 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274003479 S-adenosylmethionine binding site [chemical binding]; other site 316274003480 lysine-specific histone demethylase 1; Region: PLN02529 316274003481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274003482 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274003483 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274003484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274003485 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 316274003486 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 316274003487 Holin family; Region: Phage_holin_4; cl01989 316274003488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274003489 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316274003490 cofactor binding site; other site 316274003491 DNA binding site [nucleotide binding] 316274003492 substrate interaction site [chemical binding]; other site 316274003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274003494 Z1 domain; Region: Z1; pfam10593 316274003495 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 316274003496 active site 316274003497 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003499 active site 316274003500 phosphorylation site [posttranslational modification] 316274003501 intermolecular recognition site; other site 316274003502 dimerization interface [polypeptide binding]; other site 316274003503 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003505 active site 316274003506 phosphorylation site [posttranslational modification] 316274003507 intermolecular recognition site; other site 316274003508 dimerization interface [polypeptide binding]; other site 316274003509 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274003510 lysine-specific histone demethylase 1; Region: PLN02529 316274003511 Rhomboid family; Region: Rhomboid; cl11446 316274003512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274003513 cofactor binding site; other site 316274003514 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 316274003515 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 316274003516 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 316274003517 Phage-related protein [Function unknown]; Region: COG5412 316274003518 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 316274003519 large terminase protein; Provisional; Region: 17; PHA02533 316274003520 Terminase-like family; Region: Terminase_6; pfam03237 316274003521 methionine gamma-lyase; Provisional; Region: PRK07503 316274003522 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 316274003523 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 316274003524 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274003526 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274003527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274003528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274003529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274003530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274003531 Walker A motif; other site 316274003532 ATP binding site [chemical binding]; other site 316274003533 Walker B motif; other site 316274003534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274003535 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274003536 Walker A motif; other site 316274003537 ATP binding site [chemical binding]; other site 316274003538 Walker B motif; other site 316274003539 arginine finger; other site 316274003540 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 316274003541 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 316274003542 dimer interface [polypeptide binding]; other site 316274003543 anticodon binding site; other site 316274003544 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 316274003545 homodimer interface [polypeptide binding]; other site 316274003546 motif 1; other site 316274003547 active site 316274003548 motif 2; other site 316274003549 GAD domain; Region: GAD; pfam02938 316274003550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274003551 active site 316274003552 motif 3; other site 316274003553 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 316274003554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 316274003555 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 316274003556 DAK2 domain; Region: Dak2; cl03685 316274003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003558 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274003559 putative substrate translocation pore; other site 316274003560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003561 Cupin domain; Region: Cupin_2; cl09118 316274003562 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274003563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274003564 flagellar assembly protein J; Reviewed; Region: PRK06041 316274003565 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274003566 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274003567 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 316274003568 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 316274003569 Cellulase N-terminus domain. Cellulases are O-glycosyl hydrolases (GHs) that hydrolyze beta 1-4 glucosidic bonds in cellulose. They are usually catagorized into either exoglucanases which sequentially release sugar units from the cellulose chain and...; Region: Cellulase_N_term; cd02850 316274003570 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 316274003571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274003572 S-adenosylmethionine binding site [chemical binding]; other site 316274003573 short chain dehydrogenase; Provisional; Region: PRK06181 316274003574 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 316274003575 putative NAD(P) binding site [chemical binding]; other site 316274003576 homotetramer interface [polypeptide binding]; other site 316274003577 active site 316274003578 homodimer interface [polypeptide binding]; other site 316274003579 GAF domain; Region: GAF; cl00853 316274003580 GAF domain; Region: GAF; cl00853 316274003581 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274003582 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274003583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274003584 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274003585 anti sigma factor interaction site; other site 316274003586 regulatory phosphorylation site [posttranslational modification]; other site 316274003587 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274003588 anti sigma factor interaction site; other site 316274003589 regulatory phosphorylation site [posttranslational modification]; other site 316274003590 META domain; Region: META; cl01245 316274003591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274003592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274003593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274003594 NAD(P) binding site [chemical binding]; other site 316274003595 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274003596 active site 316274003597 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 316274003598 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274003599 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003600 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 316274003601 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 316274003602 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274003603 cyclase homology domain; Region: CHD; cd07302 316274003604 nucleotidyl binding site; other site 316274003605 metal binding site [ion binding]; metal-binding site 316274003606 dimer interface [polypeptide binding]; other site 316274003607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274003608 TPR motif; other site 316274003609 binding surface 316274003610 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 316274003611 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 316274003612 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 316274003613 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 316274003614 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316274003615 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 316274003616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274003617 Cupin domain; Region: Cupin_2; cl09118 316274003618 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274003619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274003620 Walker A motif; other site 316274003621 ATP binding site [chemical binding]; other site 316274003622 Walker B motif; other site 316274003623 arginine finger; other site 316274003624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003625 Coenzyme A binding pocket [chemical binding]; other site 316274003626 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 316274003627 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274003628 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274003629 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274003630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274003631 DNA binding site [nucleotide binding] 316274003632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274003633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274003634 binding surface 316274003635 TPR motif; other site 316274003636 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 316274003637 SmpB-tmRNA interface; other site 316274003638 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 316274003639 active site 316274003640 dimer interface [polypeptide binding]; other site 316274003641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003642 GAF domain; Region: GAF; cl00853 316274003643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003644 GAF domain; Region: GAF; cl00853 316274003645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274003646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003647 ATP binding site [chemical binding]; other site 316274003648 Mg2+ binding site [ion binding]; other site 316274003649 G-X-G motif; other site 316274003650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274003651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274003652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003653 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 316274003654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274003655 active site 316274003656 ATP binding site [chemical binding]; other site 316274003657 substrate binding site [chemical binding]; other site 316274003658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274003659 activation loop (A-loop); other site 316274003660 Predicted ATPase [General function prediction only]; Region: COG3899 316274003661 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003662 GAF domain; Region: GAF; cl00853 316274003663 GAF domain; Region: GAF; cl00853 316274003664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274003665 metal binding site [ion binding]; metal-binding site 316274003666 active site 316274003667 I-site; other site 316274003668 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274003669 Transposase domain (DUF772); Region: DUF772; cl12084 316274003670 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274003671 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274003672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274003673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274003674 catalytic residue [active] 316274003675 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274003676 Ligand binding site [chemical binding]; other site 316274003677 Putative Catalytic site [active] 316274003678 DXD motif; other site 316274003679 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 316274003680 cyclase homology domain; Region: CHD; cd07302 316274003681 nucleotidyl binding site; other site 316274003682 metal binding site [ion binding]; metal-binding site 316274003683 dimer interface [polypeptide binding]; other site 316274003684 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274003685 cyclase homology domain; Region: CHD; cd07302 316274003686 nucleotidyl binding site; other site 316274003687 dimer interface [polypeptide binding]; other site 316274003688 metal binding site [ion binding]; metal-binding site 316274003689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274003690 binding surface 316274003691 TPR motif; other site 316274003692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003693 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274003694 putative substrate translocation pore; other site 316274003695 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 316274003696 folate binding site [chemical binding]; other site 316274003697 NADP+ binding site [chemical binding]; other site 316274003698 Protein of unknown function (DUF3344); Region: DUF3344; pfam11824 316274003699 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274003700 hypothetical protein; Provisional; Region: PRK07588 316274003701 maltose O-acetyltransferase; Provisional; Region: PRK10092 316274003702 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 316274003703 active site 316274003704 substrate binding site [chemical binding]; other site 316274003705 trimer interface [polypeptide binding]; other site 316274003706 CoA binding site [chemical binding]; other site 316274003707 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 316274003708 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 316274003709 FMN binding site [chemical binding]; other site 316274003710 active site 316274003711 catalytic residues [active] 316274003712 substrate binding site [chemical binding]; other site 316274003713 Family of unknown function (DUF1790); Region: DUF1790; cl02283 316274003714 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 316274003715 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274003716 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 316274003717 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316274003718 FtsX-like permease family; Region: FtsX; pfam02687 316274003719 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316274003720 FtsX-like permease family; Region: FtsX; pfam02687 316274003721 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274003722 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 316274003723 Walker A/P-loop; other site 316274003724 ATP binding site [chemical binding]; other site 316274003725 Q-loop/lid; other site 316274003726 ABC transporter signature motif; other site 316274003727 Walker B; other site 316274003728 D-loop; other site 316274003729 H-loop/switch region; other site 316274003730 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 316274003731 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 316274003732 HSP70 interaction site [polypeptide binding]; other site 316274003733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316274003734 putative acyl-acceptor binding pocket; other site 316274003735 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 316274003736 PAS fold; Region: PAS_4; pfam08448 316274003737 putative diguanylate cyclase; Provisional; Region: PRK09776 316274003738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003739 putative active site [active] 316274003740 heme pocket [chemical binding]; other site 316274003741 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274003742 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003743 GAF domain; Region: GAF; cl00853 316274003744 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 316274003745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274003746 dimer interface [polypeptide binding]; other site 316274003747 phosphorylation site [posttranslational modification] 316274003748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003749 ATP binding site [chemical binding]; other site 316274003750 Mg2+ binding site [ion binding]; other site 316274003751 G-X-G motif; other site 316274003752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003753 active site 316274003754 phosphorylation site [posttranslational modification] 316274003755 intermolecular recognition site; other site 316274003756 dimerization interface [polypeptide binding]; other site 316274003757 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274003758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003759 active site 316274003760 phosphorylation site [posttranslational modification] 316274003761 intermolecular recognition site; other site 316274003762 dimerization interface [polypeptide binding]; other site 316274003763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274003764 Zn2+ binding site [ion binding]; other site 316274003765 Mg2+ binding site [ion binding]; other site 316274003766 Beta-lactamase; Region: Beta-lactamase; cl01009 316274003767 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 316274003768 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 316274003769 active site residues [active] 316274003770 dimer interface [polypeptide binding]; other site 316274003771 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 316274003772 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 316274003773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274003774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274003775 DNA binding site [nucleotide binding] 316274003776 domain linker motif; other site 316274003777 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 316274003778 putative dimerization interface [polypeptide binding]; other site 316274003779 putative ligand binding site [chemical binding]; other site 316274003780 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 316274003781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003782 putative substrate translocation pore; other site 316274003783 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274003784 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274003785 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 316274003786 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274003787 DNA binding residues [nucleotide binding] 316274003788 putative dimer interface [polypeptide binding]; other site 316274003789 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274003790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003791 putative substrate translocation pore; other site 316274003792 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274003793 CoenzymeA binding site [chemical binding]; other site 316274003794 subunit interaction site [polypeptide binding]; other site 316274003795 PHB binding site; other site 316274003796 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 316274003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003798 active site 316274003799 phosphorylation site [posttranslational modification] 316274003800 intermolecular recognition site; other site 316274003801 dimerization interface [polypeptide binding]; other site 316274003802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274003803 DNA binding site [nucleotide binding] 316274003804 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274003805 dimerization interface [polypeptide binding]; other site 316274003806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274003807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274003808 dimer interface [polypeptide binding]; other site 316274003809 phosphorylation site [posttranslational modification] 316274003810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003811 ATP binding site [chemical binding]; other site 316274003812 Mg2+ binding site [ion binding]; other site 316274003813 G-X-G motif; other site 316274003814 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 316274003815 putative metal binding residues [ion binding]; other site 316274003816 signature motif; other site 316274003817 dimer interface [polypeptide binding]; other site 316274003818 polyP binding site; other site 316274003819 active site 316274003820 substrate binding site [chemical binding]; other site 316274003821 acceptor-phosphate pocket; other site 316274003822 CotH protein; Region: CotH; pfam08757 316274003823 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274003824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274003825 NAD(P) binding site [chemical binding]; other site 316274003826 active site 316274003827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274003828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274003829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274003830 non-specific DNA binding site [nucleotide binding]; other site 316274003831 salt bridge; other site 316274003832 sequence-specific DNA binding site [nucleotide binding]; other site 316274003833 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 316274003834 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 316274003835 Potassium binding sites [ion binding]; other site 316274003836 Cesium cation binding sites [ion binding]; other site 316274003837 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 316274003838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274003839 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 316274003840 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 316274003841 active site 316274003842 8-oxo-dGMP binding site [chemical binding]; other site 316274003843 nudix motif; other site 316274003844 metal binding site [ion binding]; metal-binding site 316274003845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274003846 catalytic loop [active] 316274003847 iron binding site [ion binding]; other site 316274003848 cyclase homology domain; Region: CHD; cd07302 316274003849 nucleotidyl binding site; other site 316274003850 metal binding site [ion binding]; metal-binding site 316274003851 dimer interface [polypeptide binding]; other site 316274003852 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274003853 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274003854 putative NAD(P) binding site [chemical binding]; other site 316274003855 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274003856 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274003857 putative NAD(P) binding site [chemical binding]; other site 316274003858 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274003859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274003860 binding surface 316274003861 TPR motif; other site 316274003862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274003863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274003864 DNA binding residues [nucleotide binding] 316274003865 dimerization interface [polypeptide binding]; other site 316274003866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274003867 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 316274003868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 316274003869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274003870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003871 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274003872 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 316274003873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003874 substrate binding pocket [chemical binding]; other site 316274003875 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003876 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274003877 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 316274003878 DNA polymerase III subunit beta; Validated; Region: PRK05643 316274003879 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 316274003880 putative DNA binding surface [nucleotide binding]; other site 316274003881 dimer interface [polypeptide binding]; other site 316274003882 beta-clamp/clamp loader binding surface; other site 316274003883 beta-clamp/translesion DNA polymerase binding surface; other site 316274003884 Beta-lactamase; Region: Beta-lactamase; cl01009 316274003885 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 316274003886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274003887 SCP-2 sterol transfer family; Region: SCP2; cl01225 316274003888 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 316274003889 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 316274003890 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 316274003891 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 316274003892 P-loop; other site 316274003893 active site 316274003894 phosphorylation site [posttranslational modification] 316274003895 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 316274003896 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 316274003897 active site 316274003898 P-loop; other site 316274003899 phosphorylation site [posttranslational modification] 316274003900 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316274003901 active site 316274003902 phosphorylation site [posttranslational modification] 316274003903 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316274003904 dimerization domain swap beta strand [polypeptide binding]; other site 316274003905 regulatory protein interface [polypeptide binding]; other site 316274003906 active site 316274003907 regulatory phosphorylation site [posttranslational modification]; other site 316274003908 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316274003909 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 316274003910 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 316274003911 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 316274003912 NAD(P) binding site [chemical binding]; other site 316274003913 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 316274003914 putative NAD(P) binding site [chemical binding]; other site 316274003915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274003916 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274003917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274003918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274003919 CHAT domain; Region: CHAT; cl02083 316274003920 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 316274003921 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 316274003922 CPxP motif; other site 316274003923 Probable transposase; Region: OrfB_IS605; pfam01385 316274003924 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 316274003925 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 316274003926 iron-sulfur cluster [ion binding]; other site 316274003927 [2Fe-2S] cluster binding site [ion binding]; other site 316274003928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003929 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 316274003930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 316274003931 DinB superfamily; Region: DinB_2; cl00986 316274003932 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 316274003933 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 316274003934 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 316274003935 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 316274003936 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 316274003937 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274003938 catalytic residue [active] 316274003939 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 316274003940 active site 316274003941 metal binding site [ion binding]; metal-binding site 316274003942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 316274003943 active site 316274003944 UbiA prenyltransferase family; Region: UbiA; cl00337 316274003945 Sulfatase; Region: Sulfatase; cl10460 316274003946 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 316274003947 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 316274003948 putative active site [active] 316274003949 putative substrate binding site [chemical binding]; other site 316274003950 ATP binding site [chemical binding]; other site 316274003951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274003952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274003953 active site 316274003954 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274003955 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274003956 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 316274003957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274003958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274003959 active site 316274003960 phosphorylation site [posttranslational modification] 316274003961 intermolecular recognition site; other site 316274003962 dimerization interface [polypeptide binding]; other site 316274003963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274003964 DNA binding residues [nucleotide binding] 316274003965 dimerization interface [polypeptide binding]; other site 316274003966 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 316274003967 active site 316274003968 dimer interface [polypeptide binding]; other site 316274003969 Phage integrase family; Region: Phage_integrase; pfam00589 316274003970 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 316274003971 DNA binding site [nucleotide binding] 316274003972 Int/Topo IB signature motif; other site 316274003973 active site 316274003974 catalytic residues [active] 316274003975 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 316274003976 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 316274003977 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 316274003978 homodimer interface [polypeptide binding]; other site 316274003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003980 catalytic residue [active] 316274003981 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274003982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274003983 S-adenosylmethionine binding site [chemical binding]; other site 316274003984 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 316274003985 peptide synthase; Provisional; Region: PRK12467 316274003986 Condensation domain; Region: Condensation; cl09290 316274003987 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274003988 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274003989 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274003990 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274003991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274003992 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274003993 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274003994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274003995 Condensation domain; Region: Condensation; cl09290 316274003996 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274003997 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274003998 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274003999 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274004000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 316274004001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274004002 Protein of unknown function (DUF1749); Region: DUF1749; pfam08538 316274004003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004004 dimer interface [polypeptide binding]; other site 316274004005 conserved gate region; other site 316274004006 putative PBP binding loops; other site 316274004007 ABC-ATPase subunit interface; other site 316274004008 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274004009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274004010 Domain of unknown function (DU1801); Region: DUF1801; cl01838 316274004011 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274004012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274004013 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 316274004014 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 316274004015 ATP cone domain; Region: ATP-cone; pfam03477 316274004016 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 316274004017 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 316274004018 homopentamer interface [polypeptide binding]; other site 316274004019 active site 316274004020 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 316274004021 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274004022 dimer interface [polypeptide binding]; other site 316274004023 active site 316274004024 ribonuclease III; Reviewed; Region: rnc; PRK00102 316274004025 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 316274004026 dimerization interface [polypeptide binding]; other site 316274004027 active site 316274004028 metal binding site [ion binding]; metal-binding site 316274004029 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 316274004030 dsRNA binding site [nucleotide binding]; other site 316274004031 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004033 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274004034 DNA binding residues [nucleotide binding] 316274004035 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 316274004036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274004037 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274004038 Probable Catalytic site [active] 316274004039 metal binding site [ion binding]; metal-binding site 316274004040 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274004041 Putative esterase; Region: Esterase; pfam00756 316274004042 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 316274004043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004044 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 316274004045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004046 binding surface 316274004047 TPR motif; other site 316274004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274004049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274004050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004051 active site 316274004052 phosphorylation site [posttranslational modification] 316274004053 intermolecular recognition site; other site 316274004054 dimerization interface [polypeptide binding]; other site 316274004055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274004056 DNA binding residues [nucleotide binding] 316274004057 dimerization interface [polypeptide binding]; other site 316274004058 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 316274004059 Histidine kinase; Region: HisKA_3; pfam07730 316274004060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274004061 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 316274004062 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 316274004063 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316274004064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274004065 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 316274004066 Walker A/P-loop; other site 316274004067 ATP binding site [chemical binding]; other site 316274004068 Q-loop/lid; other site 316274004069 ABC transporter signature motif; other site 316274004070 Walker B; other site 316274004071 D-loop; other site 316274004072 H-loop/switch region; other site 316274004073 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316274004074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316274004075 FtsX-like permease family; Region: FtsX; pfam02687 316274004076 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 316274004077 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274004078 peptide binding site [polypeptide binding]; other site 316274004079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274004080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004081 dimer interface [polypeptide binding]; other site 316274004082 conserved gate region; other site 316274004083 putative PBP binding loops; other site 316274004084 ABC-ATPase subunit interface; other site 316274004085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274004086 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004088 dimer interface [polypeptide binding]; other site 316274004089 conserved gate region; other site 316274004090 putative PBP binding loops; other site 316274004091 ABC-ATPase subunit interface; other site 316274004092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004093 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274004094 Response regulator receiver domain; Region: Response_reg; pfam00072 316274004095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004096 active site 316274004097 phosphorylation site [posttranslational modification] 316274004098 intermolecular recognition site; other site 316274004099 dimerization interface [polypeptide binding]; other site 316274004100 GAF domain; Region: GAF; cl00853 316274004101 cyclase homology domain; Region: CHD; cd07302 316274004102 nucleotidyl binding site; other site 316274004103 metal binding site [ion binding]; metal-binding site 316274004104 dimer interface [polypeptide binding]; other site 316274004105 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 316274004106 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 316274004107 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274004108 active site 316274004109 catalytic site [active] 316274004110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004111 binding surface 316274004112 TPR motif; other site 316274004113 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274004114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274004115 S-adenosylmethionine binding site [chemical binding]; other site 316274004116 TIGR02452 family protein; Region: TIGR02452 316274004117 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 316274004118 Predicted acetyltransferase [General function prediction only]; Region: COG3393 316274004119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274004120 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 316274004121 putative dimer interface [polypeptide binding]; other site 316274004122 Found in ATP-dependent protease La (LON); Region: LON; cl01056 316274004123 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274004124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274004125 Walker A motif; other site 316274004126 ATP binding site [chemical binding]; other site 316274004127 Walker B motif; other site 316274004128 arginine finger; other site 316274004129 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274004130 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274004131 anti sigma factor interaction site; other site 316274004132 regulatory phosphorylation site [posttranslational modification]; other site 316274004133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274004134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274004135 YaeQ protein; Region: YaeQ; cl01913 316274004136 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 316274004137 endonuclease IV; Provisional; Region: PRK01060 316274004138 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 316274004139 AP (apurinic/apyrimidinic) site pocket; other site 316274004140 DNA interaction; other site 316274004141 Metal-binding active site; metal-binding site 316274004142 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 316274004143 MOSC domain; Region: MOSC; pfam03473 316274004144 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274004145 PhoU domain; Region: PhoU; pfam01895 316274004146 PhoU domain; Region: PhoU; pfam01895 316274004147 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274004148 PhoU domain; Region: PhoU; pfam01895 316274004149 PhoU domain; Region: PhoU; pfam01895 316274004150 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274004151 SLBB domain; Region: SLBB; pfam10531 316274004152 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316274004153 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 316274004154 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 316274004155 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274004156 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 316274004157 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 316274004158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316274004159 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274004160 active site residue [active] 316274004161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274004162 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274004163 active site residue [active] 316274004164 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274004167 DNA binding residues [nucleotide binding] 316274004168 Peptidase family C25; Region: Peptidase_C25; pfam01364 316274004169 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 316274004170 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 316274004171 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 316274004172 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 316274004173 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274004174 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 316274004175 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 316274004176 active site 316274004177 catalytic site [active] 316274004178 metal binding site [ion binding]; metal-binding site 316274004179 dimer interface [polypeptide binding]; other site 316274004180 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316274004181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004182 Coenzyme A binding pocket [chemical binding]; other site 316274004183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274004184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274004185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274004186 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274004187 classical (c) SDRs; Region: SDR_c; cd05233 316274004188 NAD(P) binding site [chemical binding]; other site 316274004189 active site 316274004190 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274004191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274004192 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 316274004193 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 316274004194 metal binding site [ion binding]; metal-binding site 316274004195 putative dimer interface [polypeptide binding]; other site 316274004196 Predicted permeases [General function prediction only]; Region: RarD; COG2962 316274004197 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274004198 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316274004199 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274004200 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 316274004201 Walker A/P-loop; other site 316274004202 ATP binding site [chemical binding]; other site 316274004203 Q-loop/lid; other site 316274004204 ABC transporter signature motif; other site 316274004205 Walker B; other site 316274004206 D-loop; other site 316274004207 H-loop/switch region; other site 316274004208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274004209 DNA-binding site [nucleotide binding]; DNA binding site 316274004210 Cellulose binding domain; Region: CBM_2; cl02709 316274004211 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316274004212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274004213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274004214 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 316274004215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 316274004216 putative acyl-acceptor binding pocket; other site 316274004217 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 316274004218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274004219 putative NAD(P) binding site [chemical binding]; other site 316274004220 active site 316274004221 putative substrate binding site [chemical binding]; other site 316274004222 Fic/DOC family; Region: Fic; cl00960 316274004223 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 316274004224 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 316274004225 dimer interface [polypeptide binding]; other site 316274004226 putative anticodon binding site; other site 316274004227 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 316274004228 motif 1; other site 316274004229 active site 316274004230 motif 2; other site 316274004231 motif 3; other site 316274004232 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 316274004233 domain; Region: GreA_GreB_N; pfam03449 316274004234 C-term; Region: GreA_GreB; pfam01272 316274004235 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 316274004236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274004237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274004238 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 316274004239 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 316274004240 Nuclease-related domain; Region: NERD; pfam08378 316274004241 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274004242 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274004243 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 316274004244 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 316274004245 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274004246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274004247 active site 316274004248 catalytic tetrad [active] 316274004249 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274004250 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274004251 active site 316274004252 catalytic tetrad [active] 316274004253 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 316274004254 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274004255 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274004256 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004257 tryptophan synthase; Region: PLN02591 316274004258 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 316274004259 substrate binding site [chemical binding]; other site 316274004260 active site 316274004261 catalytic residues [active] 316274004262 heterodimer interface [polypeptide binding]; other site 316274004263 Predicted permease; Region: DUF318; cl00487 316274004264 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 316274004265 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 316274004266 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 316274004267 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316274004268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004269 NmrA-like family; Region: NmrA; pfam05368 316274004270 NAD(P) binding site [chemical binding]; other site 316274004271 active site 316274004272 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274004273 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274004274 DNA binding residues [nucleotide binding] 316274004275 drug binding residues [chemical binding]; other site 316274004276 dimer interface [polypeptide binding]; other site 316274004277 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 316274004278 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274004279 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 316274004280 Integral membrane protein TerC family; Region: TerC; cl10468 316274004281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004282 binding surface 316274004283 TPR motif; other site 316274004284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004285 binding surface 316274004286 TPR motif; other site 316274004287 CHAT domain; Region: CHAT; cl02083 316274004288 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004289 Response regulator receiver domain; Region: Response_reg; pfam00072 316274004290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004291 active site 316274004292 phosphorylation site [posttranslational modification] 316274004293 intermolecular recognition site; other site 316274004294 dimerization interface [polypeptide binding]; other site 316274004295 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274004296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274004297 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 316274004298 dimer interface [polypeptide binding]; other site 316274004299 substrate binding site [chemical binding]; other site 316274004300 metal binding sites [ion binding]; metal-binding site 316274004301 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 316274004302 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 316274004303 FMN binding site [chemical binding]; other site 316274004304 substrate binding site [chemical binding]; other site 316274004305 putative catalytic residue [active] 316274004306 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 316274004307 DNA binding residues [nucleotide binding] 316274004308 putative dimer interface [polypeptide binding]; other site 316274004309 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 316274004310 DNA binding residues [nucleotide binding] 316274004311 putative dimer interface [polypeptide binding]; other site 316274004312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004313 Walker A/P-loop; other site 316274004314 ATP binding site [chemical binding]; other site 316274004315 Q-loop/lid; other site 316274004316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004317 ABC transporter signature motif; other site 316274004318 Walker B; other site 316274004319 D-loop; other site 316274004320 H-loop/switch region; other site 316274004321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004322 Walker A/P-loop; other site 316274004323 ATP binding site [chemical binding]; other site 316274004324 Q-loop/lid; other site 316274004325 ABC transporter signature motif; other site 316274004326 Walker B; other site 316274004327 D-loop; other site 316274004328 H-loop/switch region; other site 316274004329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 316274004330 UbiA prenyltransferase family; Region: UbiA; cl00337 316274004331 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 316274004332 homodimer interface [polypeptide binding]; other site 316274004333 substrate-cofactor binding pocket; other site 316274004334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004335 catalytic residue [active] 316274004336 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274004337 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 316274004338 Walker A/P-loop; other site 316274004339 ATP binding site [chemical binding]; other site 316274004340 Q-loop/lid; other site 316274004341 ABC transporter signature motif; other site 316274004342 Walker B; other site 316274004343 D-loop; other site 316274004344 H-loop/switch region; other site 316274004345 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004347 dimer interface [polypeptide binding]; other site 316274004348 conserved gate region; other site 316274004349 putative PBP binding loops; other site 316274004350 ABC-ATPase subunit interface; other site 316274004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004352 dimer interface [polypeptide binding]; other site 316274004353 conserved gate region; other site 316274004354 putative PBP binding loops; other site 316274004355 ABC-ATPase subunit interface; other site 316274004356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274004357 Transposase domain (DUF772); Region: DUF772; cl12084 316274004358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274004359 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274004360 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274004361 putative NAD(P) binding site [chemical binding]; other site 316274004362 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274004363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004364 binding surface 316274004365 TPR motif; other site 316274004366 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274004367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274004368 DNA binding residues [nucleotide binding] 316274004369 dimerization interface [polypeptide binding]; other site 316274004370 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 316274004371 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 316274004372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274004373 domain; Region: Succ_DH_flav_C; pfam02910 316274004374 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 316274004375 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 316274004376 putative Iron-sulfur protein interface [polypeptide binding]; other site 316274004377 proximal heme binding site [chemical binding]; other site 316274004378 distal heme binding site [chemical binding]; other site 316274004379 putative dimer interface [polypeptide binding]; other site 316274004380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274004381 ABC-ATPase subunit interface; other site 316274004382 dimer interface [polypeptide binding]; other site 316274004383 putative PBP binding regions; other site 316274004384 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274004385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274004386 ABC-ATPase subunit interface; other site 316274004387 dimer interface [polypeptide binding]; other site 316274004388 putative PBP binding regions; other site 316274004389 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274004390 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274004391 Walker A/P-loop; other site 316274004392 ATP binding site [chemical binding]; other site 316274004393 Q-loop/lid; other site 316274004394 ABC transporter signature motif; other site 316274004395 Walker B; other site 316274004396 D-loop; other site 316274004397 H-loop/switch region; other site 316274004398 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 316274004399 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 316274004400 siderophore binding site; other site 316274004401 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 316274004402 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 316274004403 siderophore binding site; other site 316274004404 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 316274004405 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 316274004406 OsmC-like protein; Region: OsmC; cl00767 316274004407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274004408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274004409 CTP synthetase; Validated; Region: pyrG; PRK05380 316274004410 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 316274004411 Catalytic site [active] 316274004412 Active site [active] 316274004413 UTP binding site [chemical binding]; other site 316274004414 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 316274004415 active site 316274004416 putative oxyanion hole; other site 316274004417 catalytic triad [active] 316274004418 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 316274004419 precorrin-2 dehydrogenase; Validated; Region: PRK06719 316274004420 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 316274004421 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274004422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274004423 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 316274004424 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 316274004425 ligand-binding site [chemical binding]; other site 316274004426 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 316274004427 ATP-sulfurylase; Region: ATPS; cd00517 316274004428 active site 316274004429 HXXH motif; other site 316274004430 flexible loop; other site 316274004431 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316274004432 Active Sites [active] 316274004433 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 316274004434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274004435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274004436 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 316274004437 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316274004438 active site 316274004439 NTP binding site [chemical binding]; other site 316274004440 metal binding triad [ion binding]; metal-binding site 316274004441 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274004442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274004444 DNA binding residues [nucleotide binding] 316274004445 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274004446 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 316274004447 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 316274004448 Domain of unknown function (DUF205); Region: DUF205; cl00410 316274004449 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274004450 translocation protein TolB; Provisional; Region: tolB; PRK01742 316274004451 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274004452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274004453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274004454 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 316274004455 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 316274004456 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 316274004457 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274004458 D-xylulose kinase; Region: XylB; TIGR01312 316274004459 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 316274004460 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 316274004461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004463 Uncharacterized conserved protein [Function unknown]; Region: COG4279 316274004464 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 316274004465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274004466 ATP binding site [chemical binding]; other site 316274004467 putative Mg++ binding site [ion binding]; other site 316274004468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274004469 nucleotide binding region [chemical binding]; other site 316274004470 ATP-binding site [chemical binding]; other site 316274004471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274004472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274004473 DNA binding site [nucleotide binding] 316274004474 domain linker motif; other site 316274004475 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274004476 putative dimerization interface [polypeptide binding]; other site 316274004477 putative ligand binding site [chemical binding]; other site 316274004478 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274004479 active site 316274004480 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 316274004481 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 316274004482 NAD binding site [chemical binding]; other site 316274004483 homodimer interface [polypeptide binding]; other site 316274004484 active site 316274004485 substrate binding site [chemical binding]; other site 316274004486 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274004487 CoenzymeA binding site [chemical binding]; other site 316274004488 subunit interaction site [polypeptide binding]; other site 316274004489 PHB binding site; other site 316274004490 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 316274004491 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 316274004492 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274004493 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 316274004494 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 316274004495 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 316274004496 Baseplate J-like protein; Region: Baseplate_J; cl01294 316274004497 H-type lectin domain; Region: H_lectin; pfam09458 316274004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004500 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274004501 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274004502 Probable Catalytic site [active] 316274004503 metal binding site [ion binding]; metal-binding site 316274004504 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 316274004505 Bacterial sugar transferase; Region: Bac_transf; cl00939 316274004506 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274004507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274004508 active site 316274004509 catalytic tetrad [active] 316274004510 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 316274004511 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 316274004512 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274004513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004514 NAD(P) binding site [chemical binding]; other site 316274004515 active site 316274004516 NeuB family; Region: NeuB; cl00496 316274004517 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 316274004518 isochorismate synthase DhbC; Validated; Region: PRK06923 316274004519 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316274004520 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 316274004521 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004522 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316274004523 Isochorismatase family; Region: Isochorismatase; pfam00857 316274004524 catalytic triad [active] 316274004525 conserved cis-peptide bond; other site 316274004526 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004527 Condensation domain; Region: Condensation; cl09290 316274004528 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 316274004529 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004530 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004531 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004532 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004533 thioester reductase domain; Region: Thioester-redct; TIGR01746 316274004534 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 316274004535 putative NAD(P) binding site [chemical binding]; other site 316274004536 active site 316274004537 putative substrate binding site [chemical binding]; other site 316274004538 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 316274004539 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 316274004540 siderophore binding site; other site 316274004541 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274004542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 316274004543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274004544 ABC-ATPase subunit interface; other site 316274004545 dimer interface [polypeptide binding]; other site 316274004546 putative PBP binding regions; other site 316274004547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274004548 ABC-ATPase subunit interface; other site 316274004549 dimer interface [polypeptide binding]; other site 316274004550 putative PBP binding regions; other site 316274004551 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274004552 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274004553 Walker A/P-loop; other site 316274004554 ATP binding site [chemical binding]; other site 316274004555 Q-loop/lid; other site 316274004556 ABC transporter signature motif; other site 316274004557 Walker B; other site 316274004558 D-loop; other site 316274004559 H-loop/switch region; other site 316274004560 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 316274004561 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274004562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274004563 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274004564 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274004565 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274004566 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274004567 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274004568 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274004569 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274004570 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274004571 Clostripain family; Region: Peptidase_C11; cl04055 316274004572 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316274004573 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 316274004574 active site 316274004575 Zn binding site [ion binding]; other site 316274004576 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 316274004577 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 316274004578 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274004579 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274004580 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 316274004581 putative active site [active] 316274004582 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274004583 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 316274004584 Walker A/P-loop; other site 316274004585 ATP binding site [chemical binding]; other site 316274004586 Q-loop/lid; other site 316274004587 ABC transporter signature motif; other site 316274004588 Walker B; other site 316274004589 D-loop; other site 316274004590 H-loop/switch region; other site 316274004591 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 316274004592 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274004593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274004594 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274004595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004596 Walker A/P-loop; other site 316274004597 ATP binding site [chemical binding]; other site 316274004598 Q-loop/lid; other site 316274004599 ABC transporter signature motif; other site 316274004600 Walker B; other site 316274004601 D-loop; other site 316274004602 H-loop/switch region; other site 316274004603 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274004604 Leucine-rich repeats; other site 316274004605 Substrate binding site [chemical binding]; other site 316274004606 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; Region: ROM1; COG5422 316274004607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004608 active site 316274004609 phosphorylation site [posttranslational modification] 316274004610 intermolecular recognition site; other site 316274004611 dimerization interface [polypeptide binding]; other site 316274004612 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00095 316274004613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274004616 dimer interface [polypeptide binding]; other site 316274004617 phosphorylation site [posttranslational modification] 316274004618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004619 ATP binding site [chemical binding]; other site 316274004620 Mg2+ binding site [ion binding]; other site 316274004621 G-X-G motif; other site 316274004622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004623 active site 316274004624 phosphorylation site [posttranslational modification] 316274004625 intermolecular recognition site; other site 316274004626 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316274004627 Ligand binding site [chemical binding]; other site 316274004628 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316274004629 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 316274004630 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316274004631 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 316274004632 active site/substrate binding site [active] 316274004633 tetramer interface [polypeptide binding]; other site 316274004634 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 316274004635 glycogen synthase; Provisional; Region: glgA; PRK00654 316274004636 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316274004637 ADP-binding pocket [chemical binding]; other site 316274004638 homodimer interface [polypeptide binding]; other site 316274004639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274004640 FeS/SAM binding site; other site 316274004641 coproporphyrinogen III oxidase; Validated; Region: PRK08208 316274004642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274004643 FeS/SAM binding site; other site 316274004644 HemN C-terminal region; Region: HemN_C; pfam06969 316274004645 Sulfatase; Region: Sulfatase; cl10460 316274004646 homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP); Region: Mog1; cl00169 316274004647 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274004648 Substrate binding site [chemical binding]; other site 316274004649 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274004650 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 316274004651 putative transporter; Validated; Region: PRK03818 316274004652 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 316274004653 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 316274004654 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274004655 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 316274004656 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274004657 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274004658 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 316274004659 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 316274004660 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 316274004661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004662 NAD(P) binding site [chemical binding]; other site 316274004663 active site 316274004664 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274004665 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274004666 DNA binding residues [nucleotide binding] 316274004667 dimerization interface [polypeptide binding]; other site 316274004668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274004669 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 316274004670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004671 acyl-CoA synthetase; Validated; Region: PRK05850 316274004672 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004673 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004674 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274004675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274004676 active site 316274004677 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274004678 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274004679 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004680 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 316274004681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274004682 inhibitor-cofactor binding pocket; inhibition site 316274004683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004684 catalytic residue [active] 316274004685 Condensation domain; Region: Condensation; cl09290 316274004686 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004687 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004689 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004690 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004691 Condensation domain; Region: Condensation; cl09290 316274004692 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004693 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004694 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004695 Condensation domain; Region: Condensation; cl09290 316274004696 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004697 Condensation domain; Region: Condensation; cl09290 316274004698 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004699 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004700 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004701 Condensation domain; Region: Condensation; cl09290 316274004702 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004703 Condensation domain; Region: Condensation; cl09290 316274004704 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004705 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004706 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004707 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274004708 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274004709 active site 316274004710 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274004711 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274004712 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274004713 putative NADP binding site [chemical binding]; other site 316274004714 active site 316274004715 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004716 peptide synthase; Validated; Region: PRK05691 316274004717 Condensation domain; Region: Condensation; cl09290 316274004718 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004719 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004720 Condensation domain; Region: Condensation; cl09290 316274004721 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004722 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274004723 Condensation domain; Region: Condensation; cl09290 316274004724 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004726 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274004727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274004728 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004730 putative substrate translocation pore; other site 316274004731 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 316274004732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 316274004733 dimer interface [polypeptide binding]; other site 316274004734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004735 catalytic residue [active] 316274004736 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 316274004737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004739 non-specific DNA binding site [nucleotide binding]; other site 316274004740 salt bridge; other site 316274004741 sequence-specific DNA binding site [nucleotide binding]; other site 316274004742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274004744 binding surface 316274004745 TPR motif; other site 316274004746 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316274004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004748 Coenzyme A binding pocket [chemical binding]; other site 316274004749 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 316274004750 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 316274004751 active site 316274004752 zinc binding site [ion binding]; other site 316274004753 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274004754 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 316274004755 putative active site [active] 316274004756 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274004757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004758 Walker A/P-loop; other site 316274004759 ATP binding site [chemical binding]; other site 316274004760 Q-loop/lid; other site 316274004761 ABC transporter signature motif; other site 316274004762 Walker B; other site 316274004763 D-loop; other site 316274004764 H-loop/switch region; other site 316274004765 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 316274004766 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 316274004767 active site 316274004768 substrate binding site [chemical binding]; other site 316274004769 FMN binding site [chemical binding]; other site 316274004770 putative catalytic residues [active] 316274004771 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004772 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274004773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274004774 active site 316274004775 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274004776 PKS_DH; Region: PKS_DH; smart00826 316274004777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004778 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274004779 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274004780 putative NADP binding site [chemical binding]; other site 316274004781 active site 316274004782 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004783 Condensation domain; Region: Condensation; cl09290 316274004784 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 316274004785 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004786 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004787 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004788 Condensation domain; Region: Condensation; cl09290 316274004789 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004790 Condensation domain; Region: Condensation; cl09290 316274004791 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004792 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004793 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004794 Condensation domain; Region: Condensation; cl09290 316274004795 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004796 Condensation domain; Region: Condensation; cl09290 316274004797 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004798 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 316274004799 Condensation domain; Region: Condensation; cl09290 316274004800 AMP-binding domain protein; Validated; Region: PRK08315 316274004801 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004802 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004803 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004804 Condensation domain; Region: Condensation; cl09290 316274004805 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274004806 Condensation domain; Region: Condensation; cl09290 316274004807 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004808 Condensation domain; Region: Condensation; cl09290 316274004809 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004810 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004812 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004813 Condensation domain; Region: Condensation; cl09290 316274004814 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 316274004815 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004816 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004817 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004818 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 316274004819 Condensation domain; Region: Condensation; cl09290 316274004820 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004821 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004822 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004823 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004824 Condensation domain; Region: Condensation; cl09290 316274004825 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004826 peptide synthase; Provisional; Region: PRK12467 316274004827 Condensation domain; Region: Condensation; cl09290 316274004828 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004829 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004830 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004831 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004832 Condensation domain; Region: Condensation; cl09290 316274004833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004834 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004835 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004836 Condensation domain; Region: Condensation; cl09290 316274004837 peptide synthase; Provisional; Region: PRK12316 316274004838 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004839 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004840 Condensation domain; Region: Condensation; cl09290 316274004841 peptide synthase; Provisional; Region: PRK12316 316274004842 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004843 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004844 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274004845 Condensation domain; Region: Condensation; cl09290 316274004846 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004847 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274004848 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274004849 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 316274004850 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274004851 active sites [active] 316274004852 tetramer interface [polypeptide binding]; other site 316274004853 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 316274004854 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274004855 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274004856 Thioesterase domain; Region: Thioesterase; pfam00975 316274004857 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274004858 homodimer interface [polypeptide binding]; other site 316274004859 glycosyltransferase, MGT family; Region: MGT; TIGR01426 316274004860 active site 316274004861 TDP-binding site; other site 316274004862 acceptor substrate-binding pocket; other site 316274004863 aspartate aminotransferase; Provisional; Region: PRK06836 316274004864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004866 homodimer interface [polypeptide binding]; other site 316274004867 catalytic residue [active] 316274004868 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 316274004869 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 316274004870 dimer interface [polypeptide binding]; other site 316274004871 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 316274004872 active site 316274004873 Fe binding site [ion binding]; other site 316274004874 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274004875 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274004876 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 316274004877 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274004878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004879 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 316274004880 Walker A/P-loop; other site 316274004881 ATP binding site [chemical binding]; other site 316274004882 Q-loop/lid; other site 316274004883 ABC transporter signature motif; other site 316274004884 Walker B; other site 316274004885 D-loop; other site 316274004886 H-loop/switch region; other site 316274004887 SET domain; Region: SET; cl02566 316274004888 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274004889 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274004890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274004891 dimerization interface [polypeptide binding]; other site 316274004892 DNA binding residues [nucleotide binding] 316274004893 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274004894 peptide binding site [polypeptide binding]; other site 316274004895 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274004896 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 316274004897 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274004898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004899 dimer interface [polypeptide binding]; other site 316274004900 conserved gate region; other site 316274004901 putative PBP binding loops; other site 316274004902 ABC-ATPase subunit interface; other site 316274004903 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274004904 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 316274004905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274004906 dimer interface [polypeptide binding]; other site 316274004907 conserved gate region; other site 316274004908 putative PBP binding loops; other site 316274004909 ABC-ATPase subunit interface; other site 316274004910 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274004911 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274004912 Walker A/P-loop; other site 316274004913 ATP binding site [chemical binding]; other site 316274004914 Q-loop/lid; other site 316274004915 ABC transporter signature motif; other site 316274004916 Walker B; other site 316274004917 D-loop; other site 316274004918 H-loop/switch region; other site 316274004919 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274004920 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 316274004921 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274004922 Walker A/P-loop; other site 316274004923 ATP binding site [chemical binding]; other site 316274004924 Q-loop/lid; other site 316274004925 ABC transporter signature motif; other site 316274004926 Walker B; other site 316274004927 D-loop; other site 316274004928 H-loop/switch region; other site 316274004929 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274004930 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274004931 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 316274004932 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274004933 ligand binding site [chemical binding]; other site 316274004934 dimerization interface [polypeptide binding]; other site 316274004935 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274004936 peptide chain release factor 2; Validated; Region: prfB; PRK00578 316274004937 RF-1 domain; Region: RF-1; cl02875 316274004938 RF-1 domain; Region: RF-1; cl02875 316274004939 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 316274004940 Zn binding site [ion binding]; other site 316274004941 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 316274004942 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 316274004943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004944 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 316274004945 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274004946 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274004947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274004948 dimer interface [polypeptide binding]; other site 316274004949 phosphorylation site [posttranslational modification] 316274004950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004951 ATP binding site [chemical binding]; other site 316274004952 Mg2+ binding site [ion binding]; other site 316274004953 G-X-G motif; other site 316274004954 Response regulator receiver domain; Region: Response_reg; pfam00072 316274004955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274004956 active site 316274004957 phosphorylation site [posttranslational modification] 316274004958 intermolecular recognition site; other site 316274004959 dimerization interface [polypeptide binding]; other site 316274004960 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274004961 active site residue [active] 316274004962 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316274004963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004964 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274004966 DNA binding residues [nucleotide binding] 316274004967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274004968 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 316274004969 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274004970 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274004971 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 316274004972 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 316274004973 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274004974 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274004975 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274004976 putative active site [active] 316274004977 putative NTP binding site [chemical binding]; other site 316274004978 putative nucleic acid binding site [nucleotide binding]; other site 316274004979 Type II intron maturase; Region: Intron_maturas2; pfam01348 316274004980 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 316274004981 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 316274004982 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 316274004983 substrate binding site [chemical binding]; other site 316274004984 dimer interface [polypeptide binding]; other site 316274004985 catalytic triad [active] 316274004986 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 316274004987 active site 316274004988 putative substrate binding region [chemical binding]; other site 316274004989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004990 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 316274004991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274004992 RNA binding surface [nucleotide binding]; other site 316274004993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274004994 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 316274004995 Domain of unknown function DUF11; Region: DUF11; cl03172 316274004996 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 316274004997 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274004998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274004999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005000 binding surface 316274005001 TPR motif; other site 316274005002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005003 binding surface 316274005004 TPR motif; other site 316274005005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005006 non-specific DNA binding site [nucleotide binding]; other site 316274005007 salt bridge; other site 316274005008 sequence-specific DNA binding site [nucleotide binding]; other site 316274005009 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274005010 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274005011 conserved cys residue [active] 316274005012 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 316274005013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274005014 Uncharacterized conserved protein [Function unknown]; Region: COG3270 316274005015 Predicted helicase [General function prediction only]; Region: COG4889 316274005016 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274005017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274005018 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274005021 putative inner membrane protein; Provisional; Region: PRK11099 316274005022 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274005023 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 316274005024 putative dimer interface [polypeptide binding]; other site 316274005025 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274005026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005027 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 316274005028 Beta-lactamase; Region: Beta-lactamase; cl01009 316274005029 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274005030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274005031 Coenzyme A binding pocket [chemical binding]; other site 316274005032 phosphoenolpyruvate synthase; Validated; Region: PRK06241 316274005033 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316274005034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 316274005035 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 316274005036 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 316274005037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274005038 ATP binding site [chemical binding]; other site 316274005039 putative Mg++ binding site [ion binding]; other site 316274005040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274005041 ATP-binding site [chemical binding]; other site 316274005042 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 316274005043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005044 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 316274005045 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274005046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274005047 ATP binding site [chemical binding]; other site 316274005048 putative Mg++ binding site [ion binding]; other site 316274005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274005050 nucleotide binding region [chemical binding]; other site 316274005051 ATP-binding site [chemical binding]; other site 316274005052 Uncharacterized conserved protein [Function unknown]; Region: COG4748 316274005053 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 316274005054 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 316274005055 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 316274005056 putative active site [active] 316274005057 kelch-like protein; Provisional; Region: PHA03098 316274005058 kelch-like protein; Provisional; Region: PHA03098 316274005059 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 316274005060 Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as...; Region: IPT; cd00102 316274005061 PAS fold; Region: PAS_4; pfam08448 316274005062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005063 putative active site [active] 316274005064 heme pocket [chemical binding]; other site 316274005065 hypothetical protein; Provisional; Region: PRK13560 316274005066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005067 putative active site [active] 316274005068 heme pocket [chemical binding]; other site 316274005069 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005070 putative cation:proton antiport protein; Provisional; Region: PRK10669 316274005071 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274005072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274005073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274005074 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 316274005075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005078 Cytochrome P450; Region: p450; cl12078 316274005079 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005080 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005081 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274005082 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 316274005083 protein-splicing catalytic site; other site 316274005084 thioester formation/cholesterol transfer; other site 316274005085 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 316274005086 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 316274005087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274005088 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 316274005089 DNA photolyase; Region: DNA_photolyase; pfam00875 316274005090 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 316274005091 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 316274005092 active site 316274005093 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274005094 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005095 calcium mediated ligand binding site; other site 316274005096 intermolecular salt bridges; other site 316274005097 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274005098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274005099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274005100 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274005101 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 316274005102 hydrophobic ligand binding site; other site 316274005103 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 316274005104 META domain; Region: META; cl01245 316274005105 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005106 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005107 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 316274005108 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005109 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005110 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005112 CHAT domain; Region: CHAT; cl02083 316274005113 CHAT domain; Region: CHAT; cl02083 316274005114 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005115 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274005116 Phage Tail Collar Domain; Region: Collar; pfam07484 316274005117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274005118 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274005119 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274005120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274005121 DNA binding residues [nucleotide binding] 316274005122 dimerization interface [polypeptide binding]; other site 316274005123 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 316274005124 active site 316274005125 catalytic triad [active] 316274005126 oxyanion hole [active] 316274005127 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005128 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005129 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005130 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005131 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274005132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274005133 putative substrate translocation pore; other site 316274005134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005137 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 316274005138 iron-sulfur cluster binding protein, putative; Region: TIGR00276 316274005139 4Fe-4S binding domain; Region: Fer4; cl02805 316274005140 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 316274005141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274005142 NAD(P) binding site [chemical binding]; other site 316274005143 active site 316274005144 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 316274005145 dimer interface [polypeptide binding]; other site 316274005146 substrate binding site [chemical binding]; other site 316274005147 metal binding site [ion binding]; metal-binding site 316274005148 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 316274005149 Citrate synthase; Region: Citrate_synt; pfam00285 316274005150 oxalacetate binding site [chemical binding]; other site 316274005151 citrylCoA binding site [chemical binding]; other site 316274005152 coenzyme A binding site [chemical binding]; other site 316274005153 catalytic triad [active] 316274005154 acyl-CoA synthetase; Validated; Region: PRK09192 316274005155 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005156 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005157 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005158 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274005159 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274005160 active site 316274005161 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274005162 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274005163 putative NADP binding site [chemical binding]; other site 316274005164 active site 316274005165 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005166 Condensation domain; Region: Condensation; cl09290 316274005167 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005168 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005169 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005170 Condensation domain; Region: Condensation; cl09290 316274005171 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005172 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274005173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005174 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 316274005175 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 316274005176 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 316274005177 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 316274005178 NAD binding site [chemical binding]; other site 316274005179 dimerization interface [polypeptide binding]; other site 316274005180 product binding site; other site 316274005181 substrate binding site [chemical binding]; other site 316274005182 zinc binding site [ion binding]; other site 316274005183 catalytic residues [active] 316274005184 Cytochrome P450; Region: p450; cl12078 316274005185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005186 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 316274005187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274005188 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 316274005189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274005190 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 316274005191 Ycf48-like protein; Provisional; Region: PRK13684 316274005192 Ycf48-like protein; Provisional; Region: PRK13684 316274005193 Ycf48-like protein; Provisional; Region: PRK13684 316274005194 Ycf48-like protein; Provisional; Region: PRK13684 316274005195 argininosuccinate lyase; Provisional; Region: PRK02186 316274005196 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274005197 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 316274005198 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 316274005199 active site 316274005200 non-prolyl cis peptide bond; other site 316274005201 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 316274005202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274005203 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274005204 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274005205 active site 316274005206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274005207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274005208 putative substrate translocation pore; other site 316274005209 aconitate hydratase; Validated; Region: PRK09277 316274005210 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 316274005211 substrate binding site [chemical binding]; other site 316274005212 ligand binding site [chemical binding]; other site 316274005213 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 316274005214 substrate binding site [chemical binding]; other site 316274005215 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005216 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005217 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005218 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005219 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110 316274005220 dimer interface [polypeptide binding]; other site 316274005221 Citrate synthase; Region: Citrate_synt; pfam00285 316274005222 active site 316274005223 citrylCoA binding site [chemical binding]; other site 316274005224 oxalacetate/citrate binding site [chemical binding]; other site 316274005225 coenzyme A binding site [chemical binding]; other site 316274005226 catalytic triad [active] 316274005227 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316274005228 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 316274005229 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274005230 multiple promoter invertase; Provisional; Region: mpi; PRK13413 316274005231 catalytic residues [active] 316274005232 catalytic nucleophile [active] 316274005233 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274005234 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274005235 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274005236 Synaptic Site I dimer interface [polypeptide binding]; other site 316274005237 DNA binding site [nucleotide binding] 316274005238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 316274005239 DNA-binding interface [nucleotide binding]; DNA binding site 316274005240 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 316274005241 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 316274005242 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005243 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005244 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274005245 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 316274005246 protein-splicing catalytic site; other site 316274005247 thioester formation/cholesterol transfer; other site 316274005248 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 316274005249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005251 binding surface 316274005252 TPR motif; other site 316274005253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005254 binding surface 316274005255 TPR motif; other site 316274005256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005257 binding surface 316274005258 TPR motif; other site 316274005259 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274005260 MULE transposase domain; Region: MULE; pfam10551 316274005261 Putative transposase; Region: Y2_Tnp; pfam04986 316274005262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274005263 DNA binding site [nucleotide binding] 316274005264 active site 316274005265 Int/Topo IB signature motif; other site 316274005266 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274005267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005268 non-specific DNA binding site [nucleotide binding]; other site 316274005269 salt bridge; other site 316274005270 sequence-specific DNA binding site [nucleotide binding]; other site 316274005271 Transposase domain (DUF772); Region: DUF772; cl12084 316274005272 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274005273 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274005274 Leucine-rich repeats; other site 316274005275 Substrate binding site [chemical binding]; other site 316274005276 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274005277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274005278 classical (c) SDRs; Region: SDR_c; cd05233 316274005279 NAD(P) binding site [chemical binding]; other site 316274005280 active site 316274005281 CCC1-related family of proteins; Region: CCC1_like; cl00278 316274005282 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 316274005283 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274005284 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274005285 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 316274005286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274005287 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274005288 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274005289 intersubunit interface [polypeptide binding]; other site 316274005290 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274005291 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 316274005292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005293 ABC-ATPase subunit interface; other site 316274005294 dimer interface [polypeptide binding]; other site 316274005295 putative PBP binding regions; other site 316274005296 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274005297 Integrase core domain; Region: rve; cl01316 316274005298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005299 S-adenosylmethionine binding site [chemical binding]; other site 316274005300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005301 metal binding site 2 [ion binding]; metal-binding site 316274005302 putative DNA binding helix; other site 316274005303 metal binding site 1 [ion binding]; metal-binding site 316274005304 dimer interface [polypeptide binding]; other site 316274005305 structural Zn2+ binding site [ion binding]; other site 316274005306 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274005307 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274005308 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 316274005309 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 316274005310 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 316274005311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274005312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274005313 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 316274005314 G1 box; other site 316274005315 GTP/Mg2+ binding site [chemical binding]; other site 316274005316 G2 box; other site 316274005317 Switch II region; other site 316274005318 G3 box; other site 316274005319 G4 box; other site 316274005320 G5 box; other site 316274005321 Nucleoside recognition; Region: Gate; cl00486 316274005322 Nucleoside recognition; Region: Gate; cl00486 316274005323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005324 S-adenosylmethionine binding site [chemical binding]; other site 316274005325 electron transport complex protein RnfC; Provisional; Region: PRK05035 316274005326 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 316274005327 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274005328 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274005329 homodimer interface [polypeptide binding]; other site 316274005330 active site 316274005331 TDP-binding site; other site 316274005332 acceptor substrate-binding pocket; other site 316274005333 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 316274005334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274005335 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274005336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005337 Walker A/P-loop; other site 316274005338 ATP binding site [chemical binding]; other site 316274005339 Q-loop/lid; other site 316274005340 ABC transporter signature motif; other site 316274005341 Walker B; other site 316274005342 D-loop; other site 316274005343 H-loop/switch region; other site 316274005344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274005345 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274005346 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005347 Walker A/P-loop; other site 316274005348 ATP binding site [chemical binding]; other site 316274005349 Q-loop/lid; other site 316274005350 ABC transporter signature motif; other site 316274005351 Walker B; other site 316274005352 D-loop; other site 316274005353 H-loop/switch region; other site 316274005354 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 316274005355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274005356 inhibitor-cofactor binding pocket; inhibition site 316274005357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274005358 catalytic residue [active] 316274005359 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274005360 Condensation domain; Region: Condensation; cl09290 316274005361 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005362 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005363 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274005364 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005365 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005367 Condensation domain; Region: Condensation; cl09290 316274005368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005369 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005370 Condensation domain; Region: Condensation; cl09290 316274005371 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005372 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005373 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005374 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005375 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005376 Condensation domain; Region: Condensation; cl09290 316274005377 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005378 Condensation domain; Region: Condensation; cl09290 316274005379 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005380 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005382 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274005383 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274005384 intersubunit interface [polypeptide binding]; other site 316274005385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 316274005386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274005387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005388 Walker A/P-loop; other site 316274005389 ATP binding site [chemical binding]; other site 316274005390 Q-loop/lid; other site 316274005391 ABC transporter signature motif; other site 316274005392 Walker B; other site 316274005393 D-loop; other site 316274005394 H-loop/switch region; other site 316274005395 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274005396 conserved cys residue [active] 316274005397 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274005398 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274005399 Walker A/P-loop; other site 316274005400 ATP binding site [chemical binding]; other site 316274005401 Q-loop/lid; other site 316274005402 ABC transporter signature motif; other site 316274005403 Walker B; other site 316274005404 D-loop; other site 316274005405 H-loop/switch region; other site 316274005406 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274005407 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005408 ABC-ATPase subunit interface; other site 316274005409 dimer interface [polypeptide binding]; other site 316274005410 putative PBP binding regions; other site 316274005411 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274005412 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 316274005413 intersubunit interface [polypeptide binding]; other site 316274005414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274005415 hypothetical protein; Provisional; Region: PRK08317 316274005416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005417 S-adenosylmethionine binding site [chemical binding]; other site 316274005418 Cut8; Region: Cut8; pfam08559 316274005419 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 316274005420 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 316274005421 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 316274005422 active site 316274005423 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005424 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005425 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 316274005426 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 316274005427 putative NAD(P) binding site [chemical binding]; other site 316274005428 active site 316274005429 putative substrate binding site [chemical binding]; other site 316274005430 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 316274005431 Condensation domain; Region: Condensation; cl09290 316274005432 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005433 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005434 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005435 Condensation domain; Region: Condensation; cl09290 316274005436 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005437 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005438 Condensation domain; Region: Condensation; cl09290 316274005439 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005440 acyl-CoA synthetase; Validated; Region: PRK05850 316274005441 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005443 Condensation domain; Region: Condensation; cl09290 316274005444 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 316274005445 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005446 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005447 Condensation domain; Region: Condensation; cl09290 316274005448 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005449 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005450 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274005451 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274005452 MbtH-like protein; Region: MbtH; cl01279 316274005453 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274005454 intersubunit interface [polypeptide binding]; other site 316274005455 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274005456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005457 ABC-ATPase subunit interface; other site 316274005458 dimer interface [polypeptide binding]; other site 316274005459 putative PBP binding regions; other site 316274005460 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274005461 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274005462 Walker A/P-loop; other site 316274005463 ATP binding site [chemical binding]; other site 316274005464 Q-loop/lid; other site 316274005465 ABC transporter signature motif; other site 316274005466 Walker B; other site 316274005467 D-loop; other site 316274005468 H-loop/switch region; other site 316274005469 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274005470 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 316274005471 putative switch regulator; other site 316274005472 non-specific DNA interactions [nucleotide binding]; other site 316274005473 DNA binding site [nucleotide binding] 316274005474 sequence specific DNA binding site [nucleotide binding]; other site 316274005475 putative cAMP binding site [chemical binding]; other site 316274005476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005478 binding surface 316274005479 TPR motif; other site 316274005480 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 316274005481 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 316274005482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274005483 TM-ABC transporter signature motif; other site 316274005484 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274005485 TM-ABC transporter signature motif; other site 316274005486 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 316274005487 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 316274005488 Walker A/P-loop; other site 316274005489 ATP binding site [chemical binding]; other site 316274005490 Q-loop/lid; other site 316274005491 ABC transporter signature motif; other site 316274005492 Walker B; other site 316274005493 D-loop; other site 316274005494 H-loop/switch region; other site 316274005495 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 316274005496 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274005497 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 316274005498 putative ligand binding site [chemical binding]; other site 316274005499 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274005500 putative ligand binding site [chemical binding]; other site 316274005501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274005502 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274005503 Histidine kinase; Region: His_kinase; pfam06580 316274005504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005505 ATP binding site [chemical binding]; other site 316274005506 Mg2+ binding site [ion binding]; other site 316274005507 G-X-G motif; other site 316274005508 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005510 active site 316274005511 phosphorylation site [posttranslational modification] 316274005512 intermolecular recognition site; other site 316274005513 dimerization interface [polypeptide binding]; other site 316274005514 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 316274005515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274005516 Rrf2 family protein; Region: rrf2_super; TIGR00738 316274005517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274005519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274005520 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274005521 putative substrate translocation pore; other site 316274005522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005523 S-adenosylmethionine binding site [chemical binding]; other site 316274005524 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 316274005525 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274005526 Moco binding site; other site 316274005527 metal coordination site [ion binding]; other site 316274005528 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 316274005529 Cellulose binding domain; Region: CBM_2; cl02709 316274005530 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 316274005531 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 316274005532 putative diguanylate cyclase; Provisional; Region: PRK09776 316274005533 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274005534 PAS domain S-box; Region: sensory_box; TIGR00229 316274005535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005536 putative active site [active] 316274005537 heme pocket [chemical binding]; other site 316274005538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274005539 dimer interface [polypeptide binding]; other site 316274005540 phosphorylation site [posttranslational modification] 316274005541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005542 ATP binding site [chemical binding]; other site 316274005543 G-X-G motif; other site 316274005544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274005545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005546 active site 316274005547 phosphorylation site [posttranslational modification] 316274005548 intermolecular recognition site; other site 316274005549 dimerization interface [polypeptide binding]; other site 316274005550 VPS10 domain; Region: VPS10; smart00602 316274005551 Cellulose binding domain; Region: CBM_2; cl02709 316274005552 Predicted kinase [General function prediction only]; Region: COG0645 316274005553 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274005555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316274005556 von Willebrand factor; Region: vWF_A; pfam12450 316274005557 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 316274005558 metal ion-dependent adhesion site (MIDAS); other site 316274005559 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 316274005560 secreted effector protein PipB2; Provisional; Region: PRK15196 316274005561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274005562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274005563 dimer interface [polypeptide binding]; other site 316274005564 phosphorylation site [posttranslational modification] 316274005565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005566 ATP binding site [chemical binding]; other site 316274005567 Mg2+ binding site [ion binding]; other site 316274005568 G-X-G motif; other site 316274005569 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005571 active site 316274005572 phosphorylation site [posttranslational modification] 316274005573 intermolecular recognition site; other site 316274005574 dimerization interface [polypeptide binding]; other site 316274005575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274005576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005577 active site 316274005578 phosphorylation site [posttranslational modification] 316274005579 intermolecular recognition site; other site 316274005580 dimerization interface [polypeptide binding]; other site 316274005581 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005583 active site 316274005584 phosphorylation site [posttranslational modification] 316274005585 intermolecular recognition site; other site 316274005586 dimerization interface [polypeptide binding]; other site 316274005587 ent-kaur-16-ene synthase; Region: PLN02279 316274005588 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 316274005589 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 316274005590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005591 S-adenosylmethionine binding site [chemical binding]; other site 316274005592 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005594 active site 316274005595 phosphorylation site [posttranslational modification] 316274005596 intermolecular recognition site; other site 316274005597 dimerization interface [polypeptide binding]; other site 316274005598 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274005599 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 316274005600 putative active site [active] 316274005601 putative metal binding site [ion binding]; other site 316274005602 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274005603 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274005604 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005605 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005606 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 316274005607 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 316274005608 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274005609 amidase catalytic site [active] 316274005610 Zn binding residues [ion binding]; other site 316274005611 substrate binding site [chemical binding]; other site 316274005612 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274005613 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005614 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005615 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005616 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274005617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274005618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005619 active site 316274005620 phosphorylation site [posttranslational modification] 316274005621 intermolecular recognition site; other site 316274005622 dimerization interface [polypeptide binding]; other site 316274005623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274005624 DNA binding site [nucleotide binding] 316274005625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005626 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274005627 active site 316274005628 catalytic triad [active] 316274005629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005631 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 316274005632 catalytic residues [active] 316274005633 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005635 active site 316274005636 phosphorylation site [posttranslational modification] 316274005637 intermolecular recognition site; other site 316274005638 dimerization interface [polypeptide binding]; other site 316274005639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274005640 GAF domain; Region: GAF; cl00853 316274005641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274005642 cyclase homology domain; Region: CHD; cd07302 316274005643 nucleotidyl binding site; other site 316274005644 metal binding site [ion binding]; metal-binding site 316274005645 dimer interface [polypeptide binding]; other site 316274005646 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 316274005647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274005648 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 316274005649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274005650 FeS/SAM binding site; other site 316274005651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274005652 S-adenosylmethionine binding site [chemical binding]; other site 316274005653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274005654 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274005655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274005656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274005657 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274005658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274005659 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005660 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005661 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005662 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 316274005663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274005664 Histidine kinase; Region: HisKA_3; pfam07730 316274005665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005666 ATP binding site [chemical binding]; other site 316274005667 Mg2+ binding site [ion binding]; other site 316274005668 G-X-G motif; other site 316274005669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274005670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005671 active site 316274005672 phosphorylation site [posttranslational modification] 316274005673 intermolecular recognition site; other site 316274005674 dimerization interface [polypeptide binding]; other site 316274005675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274005676 DNA binding residues [nucleotide binding] 316274005677 dimerization interface [polypeptide binding]; other site 316274005678 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 316274005679 putative sugar binding site [chemical binding]; other site 316274005680 catalytic residues [active] 316274005681 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 316274005682 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274005683 active site 316274005684 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274005685 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 316274005686 sugar binding site [chemical binding]; other site 316274005687 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274005688 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274005689 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274005690 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 316274005691 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274005692 Predicted integral membrane protein [Function unknown]; Region: COG5617 316274005693 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274005694 Ligand binding site [chemical binding]; other site 316274005695 Ligand binding site [chemical binding]; other site 316274005696 Ligand binding site [chemical binding]; other site 316274005697 Putative Catalytic site [active] 316274005698 DXD motif; other site 316274005699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274005700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274005701 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274005702 anti sigma factor interaction site; other site 316274005703 regulatory phosphorylation site [posttranslational modification]; other site 316274005704 GAF domain; Region: GAF; cl00853 316274005705 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274005706 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274005707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274005708 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274005709 anti sigma factor interaction site; other site 316274005710 regulatory phosphorylation site [posttranslational modification]; other site 316274005711 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274005712 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 316274005713 Predicted helicase [General function prediction only]; Region: COG4889 316274005714 Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347 316274005715 Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347 316274005716 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274005717 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 316274005718 putative NAD(P) binding site [chemical binding]; other site 316274005719 active site 316274005720 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274005721 active site 316274005722 catalytic triad [active] 316274005723 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 316274005724 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 316274005725 ligand binding site [chemical binding]; other site 316274005726 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 316274005727 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005729 non-specific DNA binding site [nucleotide binding]; other site 316274005730 salt bridge; other site 316274005731 sequence-specific DNA binding site [nucleotide binding]; other site 316274005732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005733 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316274005734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005735 binding surface 316274005736 TPR motif; other site 316274005737 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274005738 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 316274005739 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 316274005740 Cache domain; Region: Cache_1; pfam02743 316274005741 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 316274005742 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274005743 dimerization interface [polypeptide binding]; other site 316274005744 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005745 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 316274005746 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 316274005747 putative ligand binding site [chemical binding]; other site 316274005748 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 316274005749 homotrimer interaction site [polypeptide binding]; other site 316274005750 putative active site [active] 316274005751 Cupin domain; Region: Cupin_2; cl09118 316274005752 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 316274005753 dimer interface [polypeptide binding]; other site 316274005754 ligand binding site [chemical binding]; other site 316274005755 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316274005756 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 316274005757 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 316274005758 putative active site [active] 316274005759 putative catalytic triad [active] 316274005760 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 316274005761 HSP70 interaction site [polypeptide binding]; other site 316274005762 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 316274005763 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274005764 DinB superfamily; Region: DinB_2; cl00986 316274005765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005767 Cytochrome P450; Region: p450; cl12078 316274005768 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 316274005769 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 316274005770 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 316274005771 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cl11870 316274005772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274005773 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 316274005774 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 316274005775 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 316274005776 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274005777 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274005778 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 316274005779 trimer interface [polypeptide binding]; other site 316274005780 putative metal binding site [ion binding]; other site 316274005781 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316274005782 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 316274005783 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 316274005784 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 316274005785 putative active site [active] 316274005786 putative metal binding site [ion binding]; other site 316274005787 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 316274005788 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316274005789 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 316274005790 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 316274005791 putative acyl-acceptor binding pocket; other site 316274005792 histidyl-tRNA synthetase; Region: hisS; TIGR00442 316274005793 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 316274005794 dimer interface [polypeptide binding]; other site 316274005795 motif 1; other site 316274005796 active site 316274005797 motif 2; other site 316274005798 motif 3; other site 316274005799 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 316274005800 anticodon binding site; other site 316274005801 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274005802 peptide binding site [polypeptide binding]; other site 316274005803 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274005804 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 316274005805 aromatic arch; other site 316274005806 DCoH dimer interaction site [polypeptide binding]; other site 316274005807 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 316274005808 DCoH tetramer interaction site [polypeptide binding]; other site 316274005809 substrate binding site [chemical binding]; other site 316274005810 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 316274005811 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 316274005812 putative ADP-binding pocket [chemical binding]; other site 316274005813 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 316274005814 cyclase homology domain; Region: CHD; cd07302 316274005815 nucleotidyl binding site; other site 316274005816 metal binding site [ion binding]; metal-binding site 316274005817 dimer interface [polypeptide binding]; other site 316274005818 cyclase homology domain; Region: CHD; cd07302 316274005819 nucleotidyl binding site; other site 316274005820 metal binding site [ion binding]; metal-binding site 316274005821 dimer interface [polypeptide binding]; other site 316274005822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005823 cyclase homology domain; Region: CHD; cd07302 316274005824 nucleotidyl binding site; other site 316274005825 metal binding site [ion binding]; metal-binding site 316274005826 dimer interface [polypeptide binding]; other site 316274005827 cyclase homology domain; Region: CHD; cd07302 316274005828 nucleotidyl binding site; other site 316274005829 dimer interface [polypeptide binding]; other site 316274005830 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274005831 metal binding site [ion binding]; metal-binding site 316274005832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005833 binding surface 316274005834 TPR motif; other site 316274005835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005836 binding surface 316274005837 TPR motif; other site 316274005838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005840 binding surface 316274005841 TPR motif; other site 316274005842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005843 binding surface 316274005844 TPR motif; other site 316274005845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274005846 TPR motif; other site 316274005847 binding surface 316274005848 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 316274005849 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 316274005850 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 316274005851 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274005852 GAF domain; Region: GAF; cl00853 316274005853 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274005854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274005855 dimer interface [polypeptide binding]; other site 316274005856 phosphorylation site [posttranslational modification] 316274005857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005858 ATP binding site [chemical binding]; other site 316274005859 Mg2+ binding site [ion binding]; other site 316274005860 G-X-G motif; other site 316274005861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274005862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005863 active site 316274005864 phosphorylation site [posttranslational modification] 316274005865 intermolecular recognition site; other site 316274005866 dimerization interface [polypeptide binding]; other site 316274005867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274005868 DNA binding site [nucleotide binding] 316274005869 CoA-transferase family III; Region: CoA_transf_3; cl00778 316274005870 CoA-transferase family III; Region: CoA_transf_3; cl00778 316274005871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274005872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274005873 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274005874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274005875 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274005876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274005877 Walker A/P-loop; other site 316274005878 ATP binding site [chemical binding]; other site 316274005879 Q-loop/lid; other site 316274005880 ABC transporter signature motif; other site 316274005881 Walker B; other site 316274005882 D-loop; other site 316274005883 H-loop/switch region; other site 316274005884 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274005885 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 316274005886 putative ligand binding site [chemical binding]; other site 316274005887 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 316274005888 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274005889 amidase catalytic site [active] 316274005890 Zn binding residues [ion binding]; other site 316274005891 substrate binding site [chemical binding]; other site 316274005892 Cytochrome P450; Region: p450; cl12078 316274005893 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 316274005894 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 316274005895 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 316274005896 Ligand Binding Site [chemical binding]; other site 316274005897 GAF domain; Region: GAF; cl00853 316274005898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274005899 dimer interface [polypeptide binding]; other site 316274005900 phosphorylation site [posttranslational modification] 316274005901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005902 ATP binding site [chemical binding]; other site 316274005903 Mg2+ binding site [ion binding]; other site 316274005904 G-X-G motif; other site 316274005905 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 316274005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005907 active site 316274005908 phosphorylation site [posttranslational modification] 316274005909 intermolecular recognition site; other site 316274005910 dimerization interface [polypeptide binding]; other site 316274005911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274005912 DNA binding site [nucleotide binding] 316274005913 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 316274005914 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 316274005915 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 316274005916 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274005917 K+-transporting ATPase, c chain; Region: KdpC; cl00944 316274005918 tetratricopeptide repeat protein; Provisional; Region: PRK11788 316274005919 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274005920 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 316274005921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 316274005922 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 316274005923 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 316274005924 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer high-; Region: AAK_FomA-like; cd04241 316274005925 putative nucleotide binding site [chemical binding]; other site 316274005926 putative substrate binding site [chemical binding]; other site 316274005927 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 316274005928 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 316274005929 substrate binding site [chemical binding]; other site 316274005930 hexamer interface [polypeptide binding]; other site 316274005931 metal binding site [ion binding]; metal-binding site 316274005932 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 316274005933 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 316274005934 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316274005935 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 316274005936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274005937 Walker A motif; other site 316274005938 ATP binding site [chemical binding]; other site 316274005939 Walker B motif; other site 316274005940 arginine finger; other site 316274005941 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 316274005942 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005943 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 316274005944 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 316274005945 substrate-cofactor binding pocket; other site 316274005946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274005947 catalytic residue [active] 316274005948 Domain of unknown function DUF143; Region: DUF143; cl00519 316274005949 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 316274005950 DNA-binding site [nucleotide binding]; DNA binding site 316274005951 RNA-binding motif; other site 316274005952 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 316274005953 RNA binding site [nucleotide binding]; other site 316274005954 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 316274005955 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274005956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274005957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274005958 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 316274005959 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 316274005960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274005962 active site 316274005963 phosphorylation site [posttranslational modification] 316274005964 intermolecular recognition site; other site 316274005965 dimerization interface [polypeptide binding]; other site 316274005966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274005967 DNA binding site [nucleotide binding] 316274005968 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274005969 dimerization interface [polypeptide binding]; other site 316274005970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274005971 dimer interface [polypeptide binding]; other site 316274005972 phosphorylation site [posttranslational modification] 316274005973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005974 ATP binding site [chemical binding]; other site 316274005975 Mg2+ binding site [ion binding]; other site 316274005976 G-X-G motif; other site 316274005977 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 316274005978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274005979 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 316274005980 domain; Region: Succ_DH_flav_C; pfam02910 316274005981 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 316274005982 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 316274005983 active site 316274005984 (T/H)XGH motif; other site 316274005985 adhesin; Provisional; Region: PRK09752 316274005986 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 316274005987 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274005990 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274005991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274005992 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 316274005993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274005994 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274005995 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005996 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274005997 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 316274005998 putative ligand binding site [chemical binding]; other site 316274005999 Cytochrome P450; Region: p450; cl12078 316274006000 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006002 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 316274006003 GAF domain; Region: GAF; cl00853 316274006004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274006005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006006 ATP binding site [chemical binding]; other site 316274006007 Mg2+ binding site [ion binding]; other site 316274006008 G-X-G motif; other site 316274006009 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 316274006010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274006011 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 316274006012 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274006013 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 316274006014 catalytic triad [active] 316274006015 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 316274006016 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 316274006017 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274006018 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274006019 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 316274006020 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 316274006021 [4Fe-4S] binding site [ion binding]; other site 316274006022 molybdopterin cofactor binding site; other site 316274006023 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 316274006024 molybdopterin cofactor binding site; other site 316274006025 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 316274006026 active site 316274006027 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 316274006028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274006029 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274006030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316274006031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274006032 dimer interface [polypeptide binding]; other site 316274006033 conserved gate region; other site 316274006034 putative PBP binding loops; other site 316274006035 ABC-ATPase subunit interface; other site 316274006036 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 316274006037 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 316274006038 Walker A/P-loop; other site 316274006039 ATP binding site [chemical binding]; other site 316274006040 Q-loop/lid; other site 316274006041 ABC transporter signature motif; other site 316274006042 Walker B; other site 316274006043 D-loop; other site 316274006044 H-loop/switch region; other site 316274006045 hypothetical protein; Provisional; Region: PRK06753 316274006046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274006047 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274006048 Zn binding site [ion binding]; other site 316274006049 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 316274006050 Zn binding site [ion binding]; other site 316274006051 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 316274006052 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274006053 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 316274006054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274006055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274006056 active site 316274006057 phosphorylation site [posttranslational modification] 316274006058 intermolecular recognition site; other site 316274006059 dimerization interface [polypeptide binding]; other site 316274006060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274006061 DNA binding site [nucleotide binding] 316274006062 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 316274006063 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 316274006064 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316274006065 substrate binding pocket [chemical binding]; other site 316274006066 chain length determination region; other site 316274006067 substrate-Mg2+ binding site; other site 316274006068 catalytic residues [active] 316274006069 aspartate-rich region 1; other site 316274006070 active site lid residues [active] 316274006071 aspartate-rich region 2; other site 316274006072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274006073 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 316274006074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274006075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274006076 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316274006077 active site residue [active] 316274006078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274006079 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 316274006080 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274006081 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 316274006082 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 316274006083 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 316274006084 substrate binding site [chemical binding]; other site 316274006085 ATP binding site [chemical binding]; other site 316274006086 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 316274006087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006088 oligomerization interface [polypeptide binding]; other site 316274006089 active site 316274006090 NAD+ binding site [chemical binding]; other site 316274006091 S-adenosylmethionine synthetase; Validated; Region: PRK05250 316274006092 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 316274006093 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 316274006094 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 316274006095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274006096 Coenzyme A binding pocket [chemical binding]; other site 316274006097 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 316274006098 ADP-ribose binding site [chemical binding]; other site 316274006099 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 316274006100 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274006101 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274006102 dimerization interface [polypeptide binding]; other site 316274006103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274006104 dimer interface [polypeptide binding]; other site 316274006105 phosphorylation site [posttranslational modification] 316274006106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006107 ATP binding site [chemical binding]; other site 316274006108 G-X-G motif; other site 316274006109 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 316274006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274006111 active site 316274006112 phosphorylation site [posttranslational modification] 316274006113 intermolecular recognition site; other site 316274006114 dimerization interface [polypeptide binding]; other site 316274006115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274006116 DNA binding site [nucleotide binding] 316274006117 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 316274006118 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 316274006119 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 316274006120 Dimer interface [polypeptide binding]; other site 316274006121 anticodon binding site; other site 316274006122 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 316274006123 homodimer interface [polypeptide binding]; other site 316274006124 motif 1; other site 316274006125 motif 2; other site 316274006126 active site 316274006127 motif 3; other site 316274006128 short chain dehydrogenase; Provisional; Region: PRK06701 316274006129 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 316274006130 NAD binding site [chemical binding]; other site 316274006131 metal binding site [ion binding]; metal-binding site 316274006132 active site 316274006133 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 316274006134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274006135 active site 316274006136 phosphorylation site [posttranslational modification] 316274006137 intermolecular recognition site; other site 316274006138 dimerization interface [polypeptide binding]; other site 316274006139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006140 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 316274006141 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274006142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006143 ATP binding site [chemical binding]; other site 316274006144 G-X-G motif; other site 316274006145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 316274006146 Domain of unknown function (DUF305); Region: DUF305; pfam03713 316274006147 Domain of unknown function (DUF305); Region: DUF305; pfam03713 316274006148 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 316274006149 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274006150 dimer interface [polypeptide binding]; other site 316274006151 active site 316274006152 Cellulose binding domain; Region: CBM_2; cl02709 316274006153 CHAT domain; Region: CHAT; cl02083 316274006154 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274006155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274006156 O-Antigen ligase; Region: Wzy_C; cl04850 316274006157 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 316274006158 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274006159 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 316274006160 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274006161 active site 316274006162 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274006163 putative NTP binding site [chemical binding]; other site 316274006164 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274006165 putative active site [active] 316274006166 putative nucleic acid binding site [nucleotide binding]; other site 316274006167 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274006168 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274006169 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274006170 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 316274006171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274006172 binding surface 316274006173 TPR motif; other site 316274006174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274006175 metal binding site [ion binding]; metal-binding site 316274006176 active site 316274006177 I-site; other site 316274006178 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 316274006179 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 316274006180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274006181 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274006182 Walker A/P-loop; other site 316274006183 ATP binding site [chemical binding]; other site 316274006184 Q-loop/lid; other site 316274006185 ABC transporter signature motif; other site 316274006186 Walker B; other site 316274006187 D-loop; other site 316274006188 H-loop/switch region; other site 316274006189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274006190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274006191 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274006192 Walker A/P-loop; other site 316274006193 ATP binding site [chemical binding]; other site 316274006194 Q-loop/lid; other site 316274006195 ABC transporter signature motif; other site 316274006196 Walker B; other site 316274006197 D-loop; other site 316274006198 H-loop/switch region; other site 316274006199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274006200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274006201 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274006202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274006203 dimer interface [polypeptide binding]; other site 316274006204 conserved gate region; other site 316274006205 putative PBP binding loops; other site 316274006206 ABC-ATPase subunit interface; other site 316274006207 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274006208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274006209 dimer interface [polypeptide binding]; other site 316274006210 conserved gate region; other site 316274006211 putative PBP binding loops; other site 316274006212 ABC-ATPase subunit interface; other site 316274006213 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 316274006214 substrate binding site [chemical binding]; other site 316274006215 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274006216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274006217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274006218 DNA binding site [nucleotide binding] 316274006219 domain linker motif; other site 316274006220 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274006221 putative dimerization interface [polypeptide binding]; other site 316274006222 putative ligand binding site [chemical binding]; other site 316274006223 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 316274006224 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 316274006225 conserved cys residue [active] 316274006226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274006227 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274006228 conserved cys residue [active] 316274006229 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 316274006230 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 316274006231 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274006232 minor groove reading motif; other site 316274006233 helix-hairpin-helix signature motif; other site 316274006234 substrate binding pocket [chemical binding]; other site 316274006235 active site 316274006236 FES domain; Region: FES; smart00525 316274006237 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 316274006238 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 316274006239 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 316274006240 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274006241 active sites [active] 316274006242 tetramer interface [polypeptide binding]; other site 316274006243 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316274006244 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006245 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274006246 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274006247 active site 316274006248 TDP-binding site; other site 316274006249 acceptor substrate-binding pocket; other site 316274006250 homodimer interface [polypeptide binding]; other site 316274006251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006252 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 316274006253 Walker A/P-loop; other site 316274006254 ATP binding site [chemical binding]; other site 316274006255 Q-loop/lid; other site 316274006256 ABC transporter signature motif; other site 316274006257 Walker B; other site 316274006258 D-loop; other site 316274006259 H-loop/switch region; other site 316274006260 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006261 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274006262 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274006263 active site 316274006264 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274006265 PKS_DH; Region: PKS_DH; smart00826 316274006266 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274006267 putative NADP binding site [chemical binding]; other site 316274006268 active site 316274006269 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006270 Condensation domain; Region: Condensation; cl09290 316274006271 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006272 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274006273 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006274 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006275 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006276 Condensation domain; Region: Condensation; cl09290 316274006277 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006278 AMP-binding enzyme; Region: AMP-binding; pfam00501 316274006279 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006280 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274006281 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006282 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006283 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274006284 putative NADP binding site [chemical binding]; other site 316274006285 active site 316274006286 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006287 Condensation domain; Region: Condensation; cl09290 316274006288 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006289 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006290 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274006291 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274006293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274006294 active site 316274006295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274006296 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274006297 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274006298 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274006299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006301 Thioesterase domain; Region: Thioesterase; pfam00975 316274006302 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274006303 homodimer interface [polypeptide binding]; other site 316274006304 glycosyltransferase, MGT family; Region: MGT; TIGR01426 316274006305 active site 316274006306 TDP-binding site; other site 316274006307 acceptor substrate-binding pocket; other site 316274006308 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 316274006309 two component system sensor kinase SsrA; Provisional; Region: PRK15347 316274006310 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274006311 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274006312 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 316274006313 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 316274006314 catalytic motif [active] 316274006315 Zn binding site [ion binding]; other site 316274006316 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 316274006317 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274006318 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274006319 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 316274006320 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 316274006321 active site 316274006322 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 316274006323 active site 316274006324 Ap6A binding site [chemical binding]; other site 316274006325 nudix motif; other site 316274006326 metal binding site [ion binding]; metal-binding site 316274006327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274006328 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274006329 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274006330 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274006331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274006332 active site 316274006333 catalytic tetrad [active] 316274006334 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 316274006335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274006336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274006337 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274006338 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274006339 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 316274006340 putative active site pocket [active] 316274006341 dimerization interface [polypeptide binding]; other site 316274006342 putative catalytic residue [active] 316274006343 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 316274006344 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 316274006345 dimer interface [polypeptide binding]; other site 316274006346 substrate binding site [chemical binding]; other site 316274006347 ATP binding site [chemical binding]; other site 316274006348 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 316274006349 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 316274006350 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 316274006351 Walker A/P-loop; other site 316274006352 ATP binding site [chemical binding]; other site 316274006353 Q-loop/lid; other site 316274006354 ABC transporter signature motif; other site 316274006355 Walker B; other site 316274006356 D-loop; other site 316274006357 H-loop/switch region; other site 316274006358 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 316274006359 Walker A/P-loop; other site 316274006360 ATP binding site [chemical binding]; other site 316274006361 Q-loop/lid; other site 316274006362 ABC transporter signature motif; other site 316274006363 Walker B; other site 316274006364 D-loop; other site 316274006365 H-loop/switch region; other site 316274006366 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 316274006367 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 316274006368 thiamine phosphate binding site [chemical binding]; other site 316274006369 active site 316274006370 pyrophosphate binding site [ion binding]; other site 316274006371 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 316274006372 substrate binding site [chemical binding]; other site 316274006373 multimerization interface [polypeptide binding]; other site 316274006374 ATP binding site [chemical binding]; other site 316274006375 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 316274006376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274006377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274006378 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316274006379 catalytic triad [active] 316274006380 conserved cis-peptide bond; other site 316274006381 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 316274006382 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274006383 urease subunit alpha; Reviewed; Region: ureC; PRK13207 316274006384 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 316274006385 subunit interactions [polypeptide binding]; other site 316274006386 active site 316274006387 flap region; other site 316274006388 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 316274006389 gamma-beta subunit interface [polypeptide binding]; other site 316274006390 alpha-beta subunit interface [polypeptide binding]; other site 316274006391 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 316274006392 alpha-gamma subunit interface [polypeptide binding]; other site 316274006393 beta-gamma subunit interface [polypeptide binding]; other site 316274006394 UreD urease accessory protein; Region: UreD; cl00530 316274006395 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 316274006396 UreF; Region: UreF; pfam01730 316274006397 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274006398 active site 316274006399 ATP binding site [chemical binding]; other site 316274006400 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274006401 substrate binding site [chemical binding]; other site 316274006402 activation loop (A-loop); other site 316274006403 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 316274006404 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cd00296 316274006405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274006406 Coenzyme A binding pocket [chemical binding]; other site 316274006407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274006408 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316274006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006410 NAD(P) binding site [chemical binding]; other site 316274006411 active site 316274006412 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...; Region: ARM; cl02500 316274006413 protein binding surface [polypeptide binding]; other site 316274006414 Adaptin N terminal region; Region: Adaptin_N; pfam01602 316274006415 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 316274006416 nucleotide binding site/active site [active] 316274006417 HIT family signature motif; other site 316274006418 catalytic residue [active] 316274006419 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274006420 Interdomain contacts; other site 316274006421 Cytokine receptor motif; other site 316274006422 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274006423 Interdomain contacts; other site 316274006424 Cytokine receptor motif; other site 316274006425 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274006426 Interdomain contacts; other site 316274006427 Cytokine receptor motif; other site 316274006428 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274006429 Interdomain contacts; other site 316274006430 Cytokine receptor motif; other site 316274006431 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274006432 Interdomain contacts; other site 316274006433 Cytokine receptor motif; other site 316274006434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274006435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274006436 DNA binding site [nucleotide binding] 316274006437 domain linker motif; other site 316274006438 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 316274006439 putative dimerization interface [polypeptide binding]; other site 316274006440 putative ligand binding site [chemical binding]; other site 316274006441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274006442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006443 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274006444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274006445 DNA binding residues [nucleotide binding] 316274006446 dimerization interface [polypeptide binding]; other site 316274006447 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274006448 catalytic core [active] 316274006449 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 316274006450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274006451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274006452 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274006453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274006455 dimer interface [polypeptide binding]; other site 316274006456 conserved gate region; other site 316274006457 putative PBP binding loops; other site 316274006458 ABC-ATPase subunit interface; other site 316274006459 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274006460 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006461 Walker A/P-loop; other site 316274006462 ATP binding site [chemical binding]; other site 316274006463 Q-loop/lid; other site 316274006464 ABC transporter signature motif; other site 316274006465 Walker B; other site 316274006466 D-loop; other site 316274006467 H-loop/switch region; other site 316274006468 TOBE domain; Region: TOBE_2; cl01440 316274006469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274006470 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 316274006471 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274006472 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274006473 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 316274006474 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 316274006475 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274006476 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274006477 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274006478 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274006479 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 316274006480 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 316274006481 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 316274006482 putative dimer interface [polypeptide binding]; other site 316274006483 Protein of unknown function DUF262; Region: DUF262; cl14890 316274006484 Protein of unknown function DUF262; Region: DUF262; cl14890 316274006485 DinB superfamily; Region: DinB_2; cl00986 316274006486 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 316274006487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006488 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 316274006489 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 316274006490 active site 316274006491 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274006492 Chitinase C; Region: ChiC; pfam06483 316274006493 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 316274006494 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 316274006495 large tegument protein UL36; Provisional; Region: PHA03247 316274006496 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274006497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274006498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274006499 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274006500 PAS fold; Region: PAS_4; pfam08448 316274006501 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274006502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274006503 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 316274006504 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 316274006505 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274006506 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 316274006507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 316274006508 A subunit; Region: glycerol3P_GlpA; TIGR03377 316274006509 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 316274006510 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 316274006511 inhibitor site; inhibition site 316274006512 active site 316274006513 dimer interface [polypeptide binding]; other site 316274006514 catalytic residue [active] 316274006515 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 316274006516 dimer interface [polypeptide binding]; other site 316274006517 NADP binding site [chemical binding]; other site 316274006518 catalytic residues [active] 316274006519 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316274006520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274006521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006522 Walker A motif; other site 316274006523 ATP binding site [chemical binding]; other site 316274006524 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 316274006525 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 316274006526 ATP binding site [chemical binding]; other site 316274006527 Walker A motif; other site 316274006528 hexamer interface [polypeptide binding]; other site 316274006529 Walker B motif; other site 316274006530 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 316274006531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274006532 Coenzyme A binding pocket [chemical binding]; other site 316274006533 YCII-related domain; Region: YCII; cl00999 316274006534 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate...; Region: ASRGL1_like; cd04702 316274006535 catalytic nucleophile [active] 316274006536 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 316274006537 active site 316274006538 catalytic residues [active] 316274006539 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 316274006540 Cellulose binding domain; Region: CBM_2; cl02709 316274006541 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274006542 sugar binding site [chemical binding]; other site 316274006543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274006544 DNA binding residues [nucleotide binding] 316274006545 dimerization interface [polypeptide binding]; other site 316274006546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 316274006547 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 316274006548 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 316274006549 RuvA N terminal domain; Region: RuvA_N; pfam01330 316274006550 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274006551 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 316274006552 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 316274006553 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 316274006554 inhibitor binding site; inhibition site 316274006555 active site 316274006556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274006557 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 316274006558 domain; Region: Glyco_hydro_2; pfam00703 316274006559 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274006560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274006561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274006562 cytochrome P450 83B1; Provisional; Region: PLN03234 316274006563 Cytochrome P450; Region: p450; cl12078 316274006564 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 316274006565 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316274006566 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 316274006567 FAD binding pocket [chemical binding]; other site 316274006568 FAD binding motif [chemical binding]; other site 316274006569 catalytic residues [active] 316274006570 NAD binding pocket [chemical binding]; other site 316274006571 phosphate binding motif [ion binding]; other site 316274006572 beta-alpha-beta structure motif; other site 316274006573 PAS fold; Region: PAS_4; pfam08448 316274006574 hypothetical protein; Provisional; Region: PRK13560 316274006575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274006576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274006577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274006578 putative active site [active] 316274006579 heme pocket [chemical binding]; other site 316274006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274006581 putative active site [active] 316274006582 heme pocket [chemical binding]; other site 316274006583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274006584 dimer interface [polypeptide binding]; other site 316274006585 phosphorylation site [posttranslational modification] 316274006586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006587 ATP binding site [chemical binding]; other site 316274006588 Mg2+ binding site [ion binding]; other site 316274006589 G-X-G motif; other site 316274006590 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274006592 active site 316274006593 phosphorylation site [posttranslational modification] 316274006594 intermolecular recognition site; other site 316274006595 dimerization interface [polypeptide binding]; other site 316274006596 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 316274006597 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274006598 NAD(P) binding site [chemical binding]; other site 316274006599 catalytic residues [active] 316274006600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274006601 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 316274006602 nudix motif; other site 316274006603 Domain of unknown function DUF59; Region: DUF59; cl00941 316274006604 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316274006605 trimerization site [polypeptide binding]; other site 316274006606 active site 316274006607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006609 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 316274006610 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316274006611 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 316274006612 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 316274006613 Ligand Binding Site [chemical binding]; other site 316274006614 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 316274006615 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274006616 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274006617 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 316274006618 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 316274006619 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 316274006620 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 316274006621 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 316274006622 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 316274006623 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 316274006624 putative homodimer interface [polypeptide binding]; other site 316274006625 putative active site [active] 316274006626 catalytic site [active] 316274006627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274006628 ATP binding site [chemical binding]; other site 316274006629 putative Mg++ binding site [ion binding]; other site 316274006630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274006631 nucleotide binding region [chemical binding]; other site 316274006632 ATP-binding site [chemical binding]; other site 316274006633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274006634 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 316274006635 Sec24-related protein; Provisional; Region: PTZ00395 316274006636 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 316274006637 active site 316274006638 nucleophile elbow; other site 316274006639 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 316274006640 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 316274006641 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 316274006642 substrate binding pocket [chemical binding]; other site 316274006643 dimer interface [polypeptide binding]; other site 316274006644 inhibitor binding site; inhibition site 316274006645 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 316274006646 B12 binding site [chemical binding]; other site 316274006647 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 316274006648 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 316274006649 trimer interface [polypeptide binding]; other site 316274006650 active site 316274006651 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 316274006652 catalytic site [active] 316274006653 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 316274006654 5S rRNA interface [nucleotide binding]; other site 316274006655 CTC domain interface; other site 316274006656 L16 interface [polypeptide binding]; other site 316274006657 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 316274006658 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274006659 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274006660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274006661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274006662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274006663 DNA binding residues [nucleotide binding] 316274006664 HerA helicase [Replication, recombination, and repair]; Region: COG0433 316274006665 Domain of unknown function DUF87; Region: DUF87; pfam01935 316274006666 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 316274006667 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 316274006668 Walker A/P-loop; other site 316274006669 ATP binding site [chemical binding]; other site 316274006670 Q-loop/lid; other site 316274006671 ABC transporter signature motif; other site 316274006672 Walker B; other site 316274006673 D-loop; other site 316274006674 H-loop/switch region; other site 316274006675 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274006676 Rhomboid family; Region: Rhomboid; cl11446 316274006677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274006678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274006679 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274006680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006681 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274006682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274006683 S-adenosylmethionine binding site [chemical binding]; other site 316274006684 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 316274006685 LysE type translocator; Region: LysE; cl00565 316274006686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274006687 classical (c) SDRs; Region: SDR_c; cd05233 316274006688 NAD(P) binding site [chemical binding]; other site 316274006689 active site 316274006690 Threonine dehydrogenase; Region: TDH; cd05281 316274006691 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 316274006692 structural Zn binding site [ion binding]; other site 316274006693 catalytic Zn binding site [ion binding]; other site 316274006694 tetramer interface [polypeptide binding]; other site 316274006695 NADP binding site [chemical binding]; other site 316274006696 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800 316274006697 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316274006698 active site 316274006699 substrate binding site [chemical binding]; other site 316274006700 metal binding site [ion binding]; metal-binding site 316274006701 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 316274006702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274006703 inhibitor-cofactor binding pocket; inhibition site 316274006704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274006705 catalytic residue [active] 316274006706 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 316274006707 Uncharacterized conserved protein [Function unknown]; Region: COG0327 316274006708 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 316274006709 Integral membrane protein TerC family; Region: TerC; cl10468 316274006710 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 316274006711 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 316274006712 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 316274006713 substrate binding site [chemical binding]; other site 316274006714 THF binding site; other site 316274006715 zinc-binding site [ion binding]; other site 316274006716 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 316274006717 dimer interface [polypeptide binding]; other site 316274006718 putative radical transfer pathway; other site 316274006719 diiron center [ion binding]; other site 316274006720 tyrosyl radical; other site 316274006721 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 316274006722 Class I ribonucleotide reductase; Region: RNR_I; cd01679 316274006723 active site 316274006724 dimer interface [polypeptide binding]; other site 316274006725 catalytic residues [active] 316274006726 effector binding site; other site 316274006727 R2 peptide binding site; other site 316274006728 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274006729 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274006730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274006731 active site 316274006732 ATP binding site [chemical binding]; other site 316274006733 substrate binding site [chemical binding]; other site 316274006734 activation loop (A-loop); other site 316274006735 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274006736 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 316274006737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006740 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 316274006741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006743 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274006745 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 316274006746 phosphopeptide binding site; other site 316274006747 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274006748 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274006749 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274006750 metal ion-dependent adhesion site (MIDAS); other site 316274006751 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274006752 phosphopeptide binding site; other site 316274006753 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 316274006754 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 316274006755 tetramer interface [polypeptide binding]; other site 316274006756 TPP-binding site [chemical binding]; other site 316274006757 heterodimer interface [polypeptide binding]; other site 316274006758 phosphorylation loop region [posttranslational modification] 316274006759 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 316274006760 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 316274006761 alpha subunit interface [polypeptide binding]; other site 316274006762 TPP binding site [chemical binding]; other site 316274006763 heterodimer interface [polypeptide binding]; other site 316274006764 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274006765 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 316274006766 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274006767 E3 interaction surface; other site 316274006768 lipoyl attachment site [posttranslational modification]; other site 316274006769 e3 binding domain; Region: E3_binding; pfam02817 316274006770 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 316274006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274006772 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274006773 putative substrate translocation pore; other site 316274006774 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274006775 Ligand binding site [chemical binding]; other site 316274006776 Ligand binding site [chemical binding]; other site 316274006777 Ligand binding site [chemical binding]; other site 316274006778 Putative Catalytic site [active] 316274006779 DXD motif; other site 316274006780 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274006781 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274006782 Probable Catalytic site [active] 316274006783 metal binding site [ion binding]; metal-binding site 316274006784 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316274006785 NADP binding site [chemical binding]; other site 316274006786 active site 316274006787 putative substrate binding site [chemical binding]; other site 316274006788 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274006789 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274006790 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274006791 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274006792 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274006793 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274006794 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 316274006795 pyruvate kinase; Provisional; Region: PRK05826 316274006796 domain interfaces; other site 316274006797 active site 316274006798 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 316274006799 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316274006800 active site 316274006801 homodimer interface [polypeptide binding]; other site 316274006802 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 316274006803 active site 316274006804 catalytic triad [active] 316274006805 oxyanion hole [active] 316274006806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274006807 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 316274006808 Walker A/P-loop; other site 316274006809 ATP binding site [chemical binding]; other site 316274006810 Q-loop/lid; other site 316274006811 ABC transporter signature motif; other site 316274006812 Walker B; other site 316274006813 D-loop; other site 316274006814 H-loop/switch region; other site 316274006815 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316274006816 FtsX-like permease family; Region: FtsX; pfam02687 316274006817 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 316274006818 active site 316274006819 metal binding site [ion binding]; metal-binding site 316274006820 homotetramer interface [polypeptide binding]; other site 316274006821 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274006822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274006823 active site 316274006824 catalytic tetrad [active] 316274006825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274006826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274006827 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 316274006828 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316274006829 catalytic triad [active] 316274006830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274006831 classical (c) SDRs; Region: SDR_c; cd05233 316274006832 NAD(P) binding site [chemical binding]; other site 316274006833 active site 316274006834 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 316274006835 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316274006836 active site 316274006837 NTP binding site [chemical binding]; other site 316274006838 metal binding triad [ion binding]; metal-binding site 316274006839 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 316274006840 active site 316274006841 catalytic triad [active] 316274006842 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 316274006843 catalytic residues [active] 316274006844 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274006845 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274006846 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274006847 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274006848 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 316274006849 A subunit; Region: glycerol3P_GlpA; TIGR03377 316274006850 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 316274006851 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 316274006852 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274006853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006854 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 316274006855 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 316274006856 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 316274006857 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274006858 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274006859 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 316274006860 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 316274006861 carboxyltransferase (CT) interaction site; other site 316274006862 biotinylation site [posttranslational modification]; other site 316274006863 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 316274006864 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274006865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274006866 motif II; other site 316274006867 Phosphotransferase enzyme family; Region: APH; pfam01636 316274006868 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274006869 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons...; Region: RT_like; cl02808 316274006870 active site 316274006871 NTP binding site [chemical binding]; other site 316274006872 nucleic acid binding site [nucleotide binding]; other site 316274006873 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 316274006874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274006875 HisG, C-terminal domain; Region: HisG_C; cl06867 316274006876 Copper resistance protein CopC; Region: CopC; cl01012 316274006877 Copper resistance protein D; Region: CopD; cl00563 316274006878 Copper resistance protein CopC; Region: CopC; cl01012 316274006879 Cytochrome c; Region: Cytochrom_C; cl11414 316274006880 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274006881 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 316274006882 Walker A/P-loop; other site 316274006883 ATP binding site [chemical binding]; other site 316274006884 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 316274006885 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 316274006886 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274006887 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 316274006888 ABC transporter signature motif; other site 316274006889 Walker B; other site 316274006890 D-loop; other site 316274006891 H-loop/switch region; other site 316274006892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274006893 Coenzyme A binding pocket [chemical binding]; other site 316274006894 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 316274006895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274006897 cofactor binding site; other site 316274006898 DNA binding site [nucleotide binding] 316274006899 substrate interaction site [chemical binding]; other site 316274006900 Cellulase N-terminus domain. Cellulases are O-glycosyl hydrolases (GHs) that hydrolyze beta 1-4 glucosidic bonds in cellulose. They are usually catagorized into either exoglucanases which sequentially release sugar units from the cellulose chain and...; Region: Cellulase_N_term; cd02850 316274006901 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 316274006902 Cellulose binding domain; Region: CBM_2; cl02709 316274006903 Chitin binding domain; Region: Chitin_bind_3; cl03871 316274006904 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316274006905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274006906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274006907 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 316274006908 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316274006909 NeuB family; Region: NeuB; cl00496 316274006910 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 316274006911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274006912 NAD(P) binding site [chemical binding]; other site 316274006913 active site 316274006914 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274006915 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274006916 ligand binding site [chemical binding]; other site 316274006917 flexible hinge region; other site 316274006918 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 316274006919 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 316274006920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274006921 ATP binding site [chemical binding]; other site 316274006922 putative Mg++ binding site [ion binding]; other site 316274006923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274006924 nucleotide binding region [chemical binding]; other site 316274006925 ATP-binding site [chemical binding]; other site 316274006926 TRCF domain; Region: TRCF; pfam03461 316274006927 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274006928 peptide binding site [polypeptide binding]; other site 316274006929 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274006930 dimer interface [polypeptide binding]; other site 316274006931 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274006932 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274006933 putative active site [active] 316274006934 putative metal binding site [ion binding]; other site 316274006935 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 316274006936 GatB domain; Region: GatB_Yqey; cl11497 316274006937 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 316274006938 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 316274006939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274006940 Zn2+ binding site [ion binding]; other site 316274006941 Mg2+ binding site [ion binding]; other site 316274006942 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 316274006943 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 316274006944 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cd00596 316274006945 active site 316274006946 Zn-binding site [ion binding]; other site 316274006947 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274006948 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274006949 VanW like protein; Region: VanW; pfam04294 316274006950 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 316274006951 active site 316274006952 Thymidine kinase; Region: TK; cl00631 316274006953 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 316274006954 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 316274006955 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 316274006956 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274006957 active site 316274006958 substrate binding site [chemical binding]; other site 316274006959 Mg2+ binding site [ion binding]; other site 316274006960 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 316274006961 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 316274006962 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 316274006963 Walker A/P-loop; other site 316274006964 ATP binding site [chemical binding]; other site 316274006965 Q-loop/lid; other site 316274006966 ABC transporter signature motif; other site 316274006967 Walker B; other site 316274006968 D-loop; other site 316274006969 H-loop/switch region; other site 316274006970 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274006971 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274006972 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 316274006973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274006974 Thiamine pyrophosphokinase; Region: TPK; cd07995 316274006975 active site 316274006976 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 316274006977 dimerization interface [polypeptide binding]; other site 316274006978 thiamine binding site [chemical binding]; other site 316274006979 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274006980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274006981 motif II; other site 316274006982 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274006983 Probable Catalytic site [active] 316274006984 metal binding site [ion binding]; metal-binding site 316274006985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274006986 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274006987 putative catalytic site [active] 316274006988 putative metal binding site [ion binding]; other site 316274006989 putative phosphate binding site [ion binding]; other site 316274006990 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274006991 TM-ABC transporter signature motif; other site 316274006992 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274006993 TM-ABC transporter signature motif; other site 316274006994 Polyphosphate kinase; Region: PP_kinase; pfam02503 316274006995 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 316274006996 putative domain interface [polypeptide binding]; other site 316274006997 putative active site [active] 316274006998 catalytic site [active] 316274006999 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 316274007000 putative domain interface [polypeptide binding]; other site 316274007001 putative active site [active] 316274007002 catalytic site [active] 316274007003 Protein of unknown function (DUF983); Region: DUF983; cl02211 316274007004 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274007006 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316274007007 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274007008 Zn binding site [ion binding]; other site 316274007009 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274007010 Zn binding site [ion binding]; other site 316274007011 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 316274007012 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007013 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 316274007014 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316274007015 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316274007016 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274007017 Probable Catalytic site [active] 316274007018 metal binding site [ion binding]; metal-binding site 316274007019 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 316274007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007021 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 316274007022 VanZ like family; Region: VanZ; cl01971 316274007023 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316274007024 active site residue [active] 316274007025 Domain of unknown function (DUF309); Region: DUF309; cl00667 316274007026 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274007027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007028 active site 316274007029 phosphorylation site [posttranslational modification] 316274007030 intermolecular recognition site; other site 316274007031 dimerization interface [polypeptide binding]; other site 316274007032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274007033 Zn2+ binding site [ion binding]; other site 316274007034 Mg2+ binding site [ion binding]; other site 316274007035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007036 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 316274007037 DNA binding residues [nucleotide binding] 316274007038 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 316274007039 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 316274007040 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 316274007041 active site lid residues [active] 316274007042 substrate binding pocket [chemical binding]; other site 316274007043 catalytic residues [active] 316274007044 substrate-Mg2+ binding site; other site 316274007045 aspartate-rich region 1; other site 316274007046 aspartate-rich region 2; other site 316274007047 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316274007048 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 316274007049 putative NAD(P) binding site [chemical binding]; other site 316274007050 active site 316274007051 calcium/proton exchanger (cax); Region: cax; TIGR00378 316274007052 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 316274007053 Integral membrane protein TerC family; Region: TerC; cl10468 316274007054 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 316274007055 Recombination protein O N terminal; Region: RecO_N; pfam11967 316274007056 Recombination protein O C terminal; Region: RecO_C; pfam02565 316274007057 Bacterial membrane flanked domain; Region: DUF304; cl01348 316274007058 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274007059 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274007060 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274007061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274007062 ligand binding site [chemical binding]; other site 316274007063 flexible hinge region; other site 316274007064 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 316274007065 nucleotide binding site/active site [active] 316274007066 HIT family signature motif; other site 316274007067 catalytic residue [active] 316274007068 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 316274007069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007070 Walker A/P-loop; other site 316274007071 ATP binding site [chemical binding]; other site 316274007072 Q-loop/lid; other site 316274007073 ABC transporter signature motif; other site 316274007074 Walker B; other site 316274007075 D-loop; other site 316274007076 H-loop/switch region; other site 316274007077 CcmB protein; Region: CcmB; cl01016 316274007078 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316274007079 CcmE; Region: CcmE; cl00994 316274007080 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316274007081 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 316274007082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274007083 TPR motif; other site 316274007084 binding surface 316274007085 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 316274007086 catalytic residues [active] 316274007087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007089 active site 316274007090 phosphorylation site [posttranslational modification] 316274007091 intermolecular recognition site; other site 316274007092 dimerization interface [polypeptide binding]; other site 316274007093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274007094 DNA binding site [nucleotide binding] 316274007095 adhesin; Provisional; Region: PRK09752 316274007096 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274007097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007098 Walker A/P-loop; other site 316274007099 ATP binding site [chemical binding]; other site 316274007100 Q-loop/lid; other site 316274007101 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274007102 ABC transporter signature motif; other site 316274007103 Walker B; other site 316274007104 D-loop; other site 316274007105 ABC transporter; Region: ABC_tran_2; pfam12848 316274007106 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274007107 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 316274007108 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 316274007109 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 316274007110 CoA-binding site [chemical binding]; other site 316274007111 ATP-binding [chemical binding]; other site 316274007112 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 316274007113 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274007114 GAF domain; Region: GAF; cl00853 316274007115 GAF domain; Region: GAF; cl00853 316274007116 Histidine kinase; Region: HisKA_3; pfam07730 316274007117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007118 ATP binding site [chemical binding]; other site 316274007119 Mg2+ binding site [ion binding]; other site 316274007120 G-X-G motif; other site 316274007121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274007122 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 316274007123 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 316274007124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007125 VanW like protein; Region: VanW; pfam04294 316274007126 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274007127 GAF domain; Region: GAF; cl00853 316274007128 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007129 GAF domain; Region: GAF; cl00853 316274007130 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007131 Uncharacterized conserved protein [Function unknown]; Region: COG3603 316274007132 ABC transporter G family member; Provisional; Region: PLN03140 316274007133 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 316274007134 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 316274007135 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 316274007136 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 316274007137 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 316274007138 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 316274007139 purine monophosphate binding site [chemical binding]; other site 316274007140 dimer interface [polypeptide binding]; other site 316274007141 putative catalytic residues [active] 316274007142 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 316274007143 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 316274007144 A new structural DNA glycosylase; Region: AlkD_like; cl11434 316274007145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274007146 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274007147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007148 Walker A/P-loop; other site 316274007149 ATP binding site [chemical binding]; other site 316274007150 Q-loop/lid; other site 316274007151 ABC transporter signature motif; other site 316274007152 Walker B; other site 316274007153 D-loop; other site 316274007154 H-loop/switch region; other site 316274007155 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 316274007156 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 316274007157 active site 316274007158 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274007159 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316274007160 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 316274007161 active site 316274007162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274007163 non-specific DNA binding site [nucleotide binding]; other site 316274007164 salt bridge; other site 316274007165 sequence-specific DNA binding site [nucleotide binding]; other site 316274007166 Restriction endonuclease BamHI; Region: BamHI; pfam02923 316274007167 Restriction endonuclease BamHI; Region: BamHI; pfam02923 316274007168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007169 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316274007170 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 316274007171 Walker A/P-loop; other site 316274007172 ATP binding site [chemical binding]; other site 316274007173 Q-loop/lid; other site 316274007174 ABC transporter signature motif; other site 316274007175 Walker B; other site 316274007176 D-loop; other site 316274007177 H-loop/switch region; other site 316274007178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274007179 dimer interface [polypeptide binding]; other site 316274007180 conserved gate region; other site 316274007181 putative PBP binding loops; other site 316274007182 ABC-ATPase subunit interface; other site 316274007183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 316274007184 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316274007185 substrate binding pocket [chemical binding]; other site 316274007186 membrane-bound complex binding site; other site 316274007187 hinge residues; other site 316274007188 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274007189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274007190 putative substrate translocation pore; other site 316274007191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274007192 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 316274007193 Predicted transcriptional regulators [Transcription]; Region: COG1378 316274007194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007195 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 316274007196 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 316274007197 dimer interface [polypeptide binding]; other site 316274007198 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 316274007199 active site 316274007200 Fe binding site [ion binding]; other site 316274007201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274007202 DNA binding residues [nucleotide binding] 316274007203 dimerization interface [polypeptide binding]; other site 316274007204 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 316274007205 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274007206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007207 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274007208 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274007209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274007211 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 316274007212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274007214 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 316274007215 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274007216 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 316274007217 putative metal binding site [ion binding]; other site 316274007218 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 316274007219 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274007220 E3 interaction surface; other site 316274007221 lipoyl attachment site [posttranslational modification]; other site 316274007222 e3 binding domain; Region: E3_binding; pfam02817 316274007223 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 316274007224 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274007225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274007227 DNA binding residues [nucleotide binding] 316274007228 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 316274007229 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 316274007230 classical (c) SDRs; Region: SDR_c; cd05233 316274007231 NAD(P) binding site [chemical binding]; other site 316274007232 active site 316274007233 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 316274007234 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 316274007235 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 316274007236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274007237 active site 316274007238 substrate binding site [chemical binding]; other site 316274007239 ATP binding site [chemical binding]; other site 316274007240 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 316274007241 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 316274007242 active site 316274007243 HIGH motif; other site 316274007244 KMSKS motif; other site 316274007245 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 316274007246 tRNA binding surface [nucleotide binding]; other site 316274007247 anticodon binding site; other site 316274007248 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 316274007249 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316274007250 Walker A/P-loop; other site 316274007251 ATP binding site [chemical binding]; other site 316274007252 Q-loop/lid; other site 316274007253 ABC transporter signature motif; other site 316274007254 Walker B; other site 316274007255 D-loop; other site 316274007256 H-loop/switch region; other site 316274007257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316274007258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274007259 dimer interface [polypeptide binding]; other site 316274007260 conserved gate region; other site 316274007261 putative PBP binding loops; other site 316274007262 ABC-ATPase subunit interface; other site 316274007263 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 316274007264 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 316274007265 active site 316274007266 dimer interface [polypeptide binding]; other site 316274007267 non-prolyl cis peptide bond; other site 316274007268 insertion regions; other site 316274007269 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316274007270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 316274007271 substrate binding pocket [chemical binding]; other site 316274007272 membrane-bound complex binding site; other site 316274007273 hinge residues; other site 316274007274 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316274007275 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 316274007276 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 316274007277 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 316274007278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007279 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 316274007280 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 316274007281 peptide chain release factor 1; Validated; Region: prfA; PRK00591 316274007282 RF-1 domain; Region: RF-1; cl02875 316274007283 RF-1 domain; Region: RF-1; cl02875 316274007284 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 316274007285 active site 316274007286 purine riboside binding site [chemical binding]; other site 316274007287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274007288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274007289 dimer interface [polypeptide binding]; other site 316274007290 phosphorylation site [posttranslational modification] 316274007291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007292 ATP binding site [chemical binding]; other site 316274007293 Mg2+ binding site [ion binding]; other site 316274007294 G-X-G motif; other site 316274007295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274007296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007297 active site 316274007298 phosphorylation site [posttranslational modification] 316274007299 intermolecular recognition site; other site 316274007300 dimerization interface [polypeptide binding]; other site 316274007301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274007302 DNA binding site [nucleotide binding] 316274007303 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274007304 Domain of unknown function DUF20; Region: UPF0118; cl00465 316274007305 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274007306 Domain of unknown function DUF20; Region: UPF0118; cl00465 316274007307 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 316274007308 aspartate aminotransferase; Provisional; Region: PRK08361 316274007309 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274007310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274007311 homodimer interface [polypeptide binding]; other site 316274007312 catalytic residue [active] 316274007313 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007314 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274007315 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274007316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274007317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274007318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274007319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274007320 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 316274007321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274007322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274007323 catalytic residue [active] 316274007324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274007326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007327 epithiospecifier protein; Region: PLN02153 316274007328 Kelch motif; Region: Kelch_1; cl02701 316274007329 Kelch motif; Region: Kelch_1; cl02701 316274007330 Kelch motif; Region: Kelch_1; cl02701 316274007331 kelch-like protein; Provisional; Region: PHA03098 316274007332 Kelch motif; Region: Kelch_1; cl02701 316274007333 kelch-like protein; Provisional; Region: PHA03098 316274007334 Kelch motif; Region: Kelch_1; cl02701 316274007335 Kelch motif; Region: Kelch_1; cl02701 316274007336 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 316274007337 active site 316274007338 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274007339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007340 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274007341 sugar binding site [chemical binding]; other site 316274007342 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274007343 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 316274007344 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 316274007345 active site 316274007346 catalytic residues [active] 316274007347 Cupin domain; Region: Cupin_2; cl09118 316274007348 Cellulose binding domain; Region: CBM_2; cl02709 316274007349 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274007350 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 316274007351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274007353 DNA binding residues [nucleotide binding] 316274007354 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 316274007355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007356 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 316274007357 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 316274007358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274007359 putative substrate translocation pore; other site 316274007360 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 316274007361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007362 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 316274007363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274007364 trehalose synthase; Region: treS_nterm; TIGR02456 316274007365 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274007366 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 316274007367 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 316274007368 active site 316274007369 homotetramer interface [polypeptide binding]; other site 316274007370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274007371 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 316274007372 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 316274007373 M28, and M42; Region: Zinc_peptidase_like; cl14876 316274007374 metal binding site [ion binding]; metal-binding site 316274007375 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 316274007376 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 316274007377 active site 316274007378 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 316274007379 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 316274007380 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 316274007381 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316274007382 Response regulator receiver domain; Region: Response_reg; pfam00072 316274007383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007384 active site 316274007385 phosphorylation site [posttranslational modification] 316274007386 intermolecular recognition site; other site 316274007387 dimerization interface [polypeptide binding]; other site 316274007388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274007389 ABC-ATPase subunit interface; other site 316274007390 dimer interface [polypeptide binding]; other site 316274007391 putative PBP binding regions; other site 316274007392 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274007393 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 316274007394 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274007395 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274007396 intersubunit interface [polypeptide binding]; other site 316274007397 Sulfatase; Region: Sulfatase; cl10460 316274007398 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 316274007399 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274007400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274007401 active site 316274007402 catalytic tetrad [active] 316274007403 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 316274007404 active site 316274007405 catalytic residues [active] 316274007406 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_subtilisin_1; cd04818 316274007407 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 316274007408 PA/protease or protease-like domain interface [polypeptide binding]; other site 316274007409 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316274007410 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 316274007411 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 316274007412 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 316274007413 active site 316274007414 dimer interface [polypeptide binding]; other site 316274007415 motif 1; other site 316274007416 motif 2; other site 316274007417 motif 3; other site 316274007418 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 316274007419 anticodon binding site; other site 316274007420 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274007421 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274007422 catalytic site [active] 316274007423 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 316274007424 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316274007425 HIGH motif; other site 316274007426 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316274007427 active site 316274007428 KMSKS motif; other site 316274007429 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 316274007430 tRNA binding surface [nucleotide binding]; other site 316274007431 anticodon binding site; other site 316274007432 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 316274007433 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 316274007434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007435 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 316274007436 FemAB family; Region: FemAB; cl11444 316274007437 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 316274007438 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 316274007439 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 316274007440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007441 ATP binding site [chemical binding]; other site 316274007442 Mg2+ binding site [ion binding]; other site 316274007443 G-X-G motif; other site 316274007444 sulfite oxidase; Provisional; Region: PLN00177 316274007445 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274007446 Moco binding site; other site 316274007447 metal coordination site [ion binding]; other site 316274007448 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 316274007449 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274007450 AMMECR1; Region: AMMECR1; cl00911 316274007451 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 316274007452 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316274007453 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 316274007454 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 316274007455 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316274007456 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 316274007457 lipoyl attachment site [posttranslational modification]; other site 316274007458 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 316274007459 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 316274007460 tetramer interface [polypeptide binding]; other site 316274007461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274007462 catalytic residue [active] 316274007463 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 316274007464 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 316274007465 tetramer interface [polypeptide binding]; other site 316274007466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274007467 catalytic residue [active] 316274007468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274007469 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274007471 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274007472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007473 Beta-lactamase; Region: Beta-lactamase; cl01009 316274007474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007475 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 316274007476 Walker A/P-loop; other site 316274007477 ATP binding site [chemical binding]; other site 316274007478 Q-loop/lid; other site 316274007479 ABC transporter signature motif; other site 316274007480 Walker B; other site 316274007481 D-loop; other site 316274007482 H-loop/switch region; other site 316274007483 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274007484 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274007485 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274007486 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 316274007487 NADP binding site [chemical binding]; other site 316274007488 dimer interface [polypeptide binding]; other site 316274007489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007490 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512 316274007491 active site 316274007492 dimer interface [polypeptide binding]; other site 316274007493 catalytic nucleophile [active] 316274007494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274007495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274007496 NAD(P) binding site [chemical binding]; other site 316274007497 active site 316274007498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274007499 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 316274007500 ligand binding site [chemical binding]; other site 316274007501 flexible hinge region; other site 316274007502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007503 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274007504 putative active site [active] 316274007505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274007506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274007507 active site 316274007508 metal binding site [ion binding]; metal-binding site 316274007509 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274007510 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274007511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274007513 cytochrome P450 83B1; Provisional; Region: PLN03234 316274007514 Cytochrome P450; Region: p450; cl12078 316274007515 Resistant to P. syringae 6; Provisional; Region: PLN03210 316274007516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274007518 NAD(P) binding site [chemical binding]; other site 316274007519 active site 316274007520 sulfate transport protein; Provisional; Region: cysT; CHL00187 316274007521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274007522 dimer interface [polypeptide binding]; other site 316274007523 conserved gate region; other site 316274007524 putative PBP binding loops; other site 316274007525 ABC-ATPase subunit interface; other site 316274007526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274007527 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274007528 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316274007529 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274007530 RNA binding surface [nucleotide binding]; other site 316274007531 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 316274007532 active site 316274007533 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 316274007534 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274007535 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274007536 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274007537 active site 316274007538 metal binding site [ion binding]; metal-binding site 316274007539 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274007540 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274007541 E3 Ubiquitin ligase; Region: GIDE; pfam12483 316274007542 Peptidase family M48; Region: Peptidase_M48; cl12018 316274007543 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 316274007544 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 316274007545 active site 316274007546 Zn binding site [ion binding]; other site 316274007547 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 316274007548 NHL repeat; Region: NHL; pfam01436 316274007549 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274007550 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274007551 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274007552 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274007553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274007554 Predicted esterase [General function prediction only]; Region: COG0400 316274007555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274007557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274007558 NAD(P) binding site [chemical binding]; other site 316274007559 active site 316274007560 TIGR01177 family protein; Region: TIGR01177 316274007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274007562 S-adenosylmethionine binding site [chemical binding]; other site 316274007563 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 316274007564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 316274007565 TPR motif; other site 316274007566 binding surface 316274007567 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 316274007568 putative active site [active] 316274007569 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 316274007570 putative active site [active] 316274007571 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 316274007572 Active_site [active] 316274007573 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316274007574 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 316274007575 putative [Fe4-S4] binding site [ion binding]; other site 316274007576 putative molybdopterin cofactor binding site [chemical binding]; other site 316274007577 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 316274007578 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 316274007579 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 316274007580 G1 box; other site 316274007581 GTP/Mg2+ binding site [chemical binding]; other site 316274007582 Switch I region; other site 316274007583 G2 box; other site 316274007584 G3 box; other site 316274007585 Switch II region; other site 316274007586 G4 box; other site 316274007587 G5 box; other site 316274007588 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274007589 amidase catalytic site [active] 316274007590 Zn binding residues [ion binding]; other site 316274007591 substrate binding site [chemical binding]; other site 316274007592 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274007593 catalytic core [active] 316274007594 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 316274007595 Cache domain; Region: Cache_1; pfam02743 316274007596 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274007597 dimerization interface [polypeptide binding]; other site 316274007598 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 316274007599 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007600 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274007601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274007602 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 316274007603 NADP binding site [chemical binding]; other site 316274007604 active site 316274007605 steroid binding site; other site 316274007606 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 316274007607 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007608 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 316274007609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274007611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 316274007612 active site 316274007613 phosphorylation site [posttranslational modification] 316274007614 intermolecular recognition site; other site 316274007615 dimerization interface [polypeptide binding]; other site 316274007616 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274007617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274007618 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 316274007619 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 316274007620 putative active site; other site 316274007621 catalytic residue [active] 316274007622 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274007623 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274007624 nudix motif; other site 316274007625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274007626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 316274007628 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 316274007629 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 316274007630 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 316274007631 putative NAD(P) binding site [chemical binding]; other site 316274007632 putative substrate binding site [chemical binding]; other site 316274007633 catalytic Zn binding site [ion binding]; other site 316274007634 structural Zn binding site [ion binding]; other site 316274007635 dimer interface [polypeptide binding]; other site 316274007636 PAS fold; Region: PAS_4; pfam08448 316274007637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274007638 putative active site [active] 316274007639 heme pocket [chemical binding]; other site 316274007640 hypothetical protein; Provisional; Region: PRK13560 316274007641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274007642 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007643 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007644 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274007645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007648 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 316274007649 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274007650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274007651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274007652 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 316274007653 putative active site [active] 316274007654 catalytic site [active] 316274007655 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 316274007656 putative active site [active] 316274007657 catalytic site [active] 316274007658 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274007659 active site 316274007660 ATP binding site [chemical binding]; other site 316274007661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007662 substrate binding site [chemical binding]; other site 316274007663 activation loop (A-loop); other site 316274007664 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 316274007665 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 316274007666 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 316274007667 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 316274007668 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 316274007669 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316274007670 Rrf2 family protein; Region: rrf2_super; TIGR00738 316274007671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274007672 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274007673 selenocysteine synthase; Provisional; Region: PRK04311 316274007674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274007675 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007676 active site 316274007677 ATP binding site [chemical binding]; other site 316274007678 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007679 substrate binding site [chemical binding]; other site 316274007680 activation loop (A-loop); other site 316274007681 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274007682 phosphopeptide binding site; other site 316274007683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274007684 DNA binding site [nucleotide binding] 316274007685 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 316274007686 G1 box; other site 316274007687 GTP/Mg2+ binding site [chemical binding]; other site 316274007688 Switch I region; other site 316274007689 G2 box; other site 316274007690 Switch II region; other site 316274007691 G3 box; other site 316274007692 G4 box; other site 316274007693 G5 box; other site 316274007694 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274007695 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274007696 Protein of unknown function (DUF952); Region: DUF952; cl01393 316274007697 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 316274007698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274007699 active site 316274007700 HIGH motif; other site 316274007701 nucleotide binding site [chemical binding]; other site 316274007702 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 316274007703 active site 316274007704 KMSKS motif; other site 316274007705 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 316274007706 tRNA binding surface [nucleotide binding]; other site 316274007707 anticodon binding site; other site 316274007708 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 316274007709 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 316274007710 trimer interface [polypeptide binding]; other site 316274007711 active site 316274007712 dimer interface [polypeptide binding]; other site 316274007713 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316274007714 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 316274007715 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 316274007716 Putative Ig domain; Region: He_PIG; cl09256 316274007717 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 316274007718 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 316274007719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007720 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 316274007721 active site 316274007722 metal binding site [ion binding]; metal-binding site 316274007723 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 316274007724 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 316274007725 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 316274007726 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007727 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274007728 substrate binding pocket [chemical binding]; other site 316274007729 substrate-Mg2+ binding site; other site 316274007730 aspartate-rich region 1; other site 316274007731 aspartate-rich region 2; other site 316274007732 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274007733 substrate binding pocket [chemical binding]; other site 316274007734 substrate-Mg2+ binding site; other site 316274007735 aspartate-rich region 1; other site 316274007736 aspartate-rich region 2; other site 316274007737 aminodeoxychorismate synthase; Provisional; Region: PRK07508 316274007738 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316274007739 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 316274007740 substrate-cofactor binding pocket; other site 316274007741 homodimer interface [polypeptide binding]; other site 316274007742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274007743 catalytic residue [active] 316274007744 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 316274007745 active site 316274007746 ribulose/triose binding site [chemical binding]; other site 316274007747 phosphate binding site [ion binding]; other site 316274007748 substrate (anthranilate) binding pocket [chemical binding]; other site 316274007749 product (indole) binding pocket [chemical binding]; other site 316274007750 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 316274007751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007752 Walker A/P-loop; other site 316274007753 ATP binding site [chemical binding]; other site 316274007754 Q-loop/lid; other site 316274007755 ABC transporter signature motif; other site 316274007756 Walker B; other site 316274007757 D-loop; other site 316274007758 H-loop/switch region; other site 316274007759 ABC transporter; Region: ABC_tran_2; pfam12848 316274007760 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274007761 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 316274007762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274007763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274007764 dimerization interface [polypeptide binding]; other site 316274007765 putative DNA binding site [nucleotide binding]; other site 316274007766 putative Zn2+ binding site [ion binding]; other site 316274007767 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 316274007768 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 316274007769 CPxP motif; other site 316274007770 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274007771 Found in ATP-dependent protease La (LON); Region: LON; cl01056 316274007772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274007773 Walker A motif; other site 316274007774 ATP binding site [chemical binding]; other site 316274007775 Walker B motif; other site 316274007776 arginine finger; other site 316274007777 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274007778 Response regulator receiver domain; Region: Response_reg; pfam00072 316274007779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007780 active site 316274007781 phosphorylation site [posttranslational modification] 316274007782 intermolecular recognition site; other site 316274007783 dimerization interface [polypeptide binding]; other site 316274007784 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274007785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274007786 S-adenosylmethionine binding site [chemical binding]; other site 316274007787 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 316274007788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007789 ATP binding site [chemical binding]; other site 316274007790 Mg2+ binding site [ion binding]; other site 316274007791 G-X-G motif; other site 316274007792 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 316274007793 ATP binding site [chemical binding]; other site 316274007794 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 316274007795 Cupin domain; Region: Cupin_2; cl09118 316274007796 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 316274007797 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 316274007798 Walker A/P-loop; other site 316274007799 ATP binding site [chemical binding]; other site 316274007800 Q-loop/lid; other site 316274007801 ABC transporter signature motif; other site 316274007802 Walker B; other site 316274007803 D-loop; other site 316274007804 H-loop/switch region; other site 316274007805 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274007806 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 316274007807 Walker A/P-loop; other site 316274007808 ATP binding site [chemical binding]; other site 316274007809 Q-loop/lid; other site 316274007810 ABC transporter signature motif; other site 316274007811 Walker B; other site 316274007812 D-loop; other site 316274007813 H-loop/switch region; other site 316274007814 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274007815 TM-ABC transporter signature motif; other site 316274007816 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274007817 TM-ABC transporter signature motif; other site 316274007818 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 316274007819 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274007820 dimerization interface [polypeptide binding]; other site 316274007821 ligand binding site [chemical binding]; other site 316274007822 Glycosyl hydrolase family 71; Region: Glyco_hydro_71; pfam03659 316274007823 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 316274007824 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 316274007825 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274007826 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274007827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274007828 Walker A/P-loop; other site 316274007829 ATP binding site [chemical binding]; other site 316274007830 Q-loop/lid; other site 316274007831 ABC transporter signature motif; other site 316274007832 Walker B; other site 316274007833 D-loop; other site 316274007834 H-loop/switch region; other site 316274007835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007837 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274007838 active site 316274007839 catalytic triad [active] 316274007840 CHASE4 domain; Region: CHASE4; cl01308 316274007841 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274007842 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007843 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 316274007844 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274007845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274007846 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316274007847 metal binding site 2 [ion binding]; metal-binding site 316274007848 putative DNA binding helix; other site 316274007849 metal binding site 1 [ion binding]; metal-binding site 316274007850 dimer interface [polypeptide binding]; other site 316274007851 structural Zn2+ binding site [ion binding]; other site 316274007852 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 316274007853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274007854 dimer interface [polypeptide binding]; other site 316274007855 phosphorylation site [posttranslational modification] 316274007856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007857 ATP binding site [chemical binding]; other site 316274007858 Mg2+ binding site [ion binding]; other site 316274007859 G-X-G motif; other site 316274007860 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 316274007861 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 316274007862 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 316274007863 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 316274007864 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 316274007865 putative active site [active] 316274007866 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274007867 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316274007868 Catalytic site [active] 316274007869 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316274007870 Catalytic site [active] 316274007871 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 316274007872 Ligand Binding Site [chemical binding]; other site 316274007873 B3/4 domain; Region: B3_4; cl11458 316274007874 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274007875 FtsH Extracellular; Region: FtsH_ext; pfam06480 316274007876 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 316274007877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274007878 Walker A motif; other site 316274007879 ATP binding site [chemical binding]; other site 316274007880 Walker B motif; other site 316274007881 arginine finger; other site 316274007882 Peptidase family M41; Region: Peptidase_M41; pfam01434 316274007883 Domain of unknown function DUF28; Region: DUF28; cl00361 316274007884 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274007885 phosphopeptide binding site; other site 316274007886 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 316274007887 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007888 active site 316274007889 ATP binding site [chemical binding]; other site 316274007890 substrate binding site [chemical binding]; other site 316274007891 activation loop (A-loop); other site 316274007892 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274007893 Calx-beta domain; Region: Calx-beta; cl02522 316274007894 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 316274007895 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007896 active site 316274007897 ATP binding site [chemical binding]; other site 316274007898 substrate binding site [chemical binding]; other site 316274007899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007900 activation loop (A-loop); other site 316274007901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007902 active site 316274007903 ATP binding site [chemical binding]; other site 316274007904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007905 substrate binding site [chemical binding]; other site 316274007906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274007907 substrate binding site [chemical binding]; other site 316274007908 activation loop (A-loop); other site 316274007909 activation loop (A-loop); other site 316274007910 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 316274007911 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 316274007912 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 316274007913 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274007914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274007916 ABC-ATPase subunit interface; other site 316274007917 dimer interface [polypeptide binding]; other site 316274007918 putative PBP binding regions; other site 316274007919 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274007920 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 316274007921 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274007922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274007923 intersubunit interface [polypeptide binding]; other site 316274007924 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274007925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274007927 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274007928 translocation protein TolB; Provisional; Region: tolB; PRK04922 316274007929 mercuric reductase; Validated; Region: PRK06370 316274007930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274007932 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274007933 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 316274007934 ligand binding site [chemical binding]; other site 316274007935 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 316274007936 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 316274007937 Walker A/P-loop; other site 316274007938 ATP binding site [chemical binding]; other site 316274007939 Q-loop/lid; other site 316274007940 ABC transporter signature motif; other site 316274007941 Walker B; other site 316274007942 D-loop; other site 316274007943 H-loop/switch region; other site 316274007944 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 316274007945 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274007946 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274007947 TM-ABC transporter signature motif; other site 316274007948 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274007949 TM-ABC transporter signature motif; other site 316274007950 CHAT domain; Region: CHAT; cl02083 316274007951 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274007952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274007953 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 316274007954 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 316274007955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274007956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274007957 active site 316274007958 phosphorylation site [posttranslational modification] 316274007959 intermolecular recognition site; other site 316274007960 dimerization interface [polypeptide binding]; other site 316274007961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274007962 DNA binding site [nucleotide binding] 316274007963 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274007964 dimerization interface [polypeptide binding]; other site 316274007965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274007966 dimer interface [polypeptide binding]; other site 316274007967 phosphorylation site [posttranslational modification] 316274007968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007969 ATP binding site [chemical binding]; other site 316274007970 G-X-G motif; other site 316274007971 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274007972 CoenzymeA binding site [chemical binding]; other site 316274007973 subunit interaction site [polypeptide binding]; other site 316274007974 PHB binding site; other site 316274007975 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 316274007976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274007977 active site 316274007978 motif I; other site 316274007979 motif II; other site 316274007980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274007981 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 316274007982 active site 316274007983 putative substrate binding region [chemical binding]; other site 316274007984 LysE type translocator; Region: LysE; cl00565 316274007985 Double zinc ribbon; Region: DZR; pfam12773 316274007986 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007987 active site 316274007988 ATP binding site [chemical binding]; other site 316274007989 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007990 substrate binding site [chemical binding]; other site 316274007991 activation loop (A-loop); other site 316274007992 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274007993 Isochorismatase family; Region: Isochorismatase; pfam00857 316274007994 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 316274007995 catalytic triad [active] 316274007996 conserved cis-peptide bond; other site 316274007997 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274007998 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274007999 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 316274008000 Walker A/P-loop; other site 316274008001 ATP binding site [chemical binding]; other site 316274008002 Q-loop/lid; other site 316274008003 ABC transporter signature motif; other site 316274008004 Walker B; other site 316274008005 D-loop; other site 316274008006 H-loop/switch region; other site 316274008007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008008 Cytochrome P450; Region: p450; cl12078 316274008009 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274008010 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274008011 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 316274008012 TM0106 family; Region: TIGR03491 316274008013 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316274008014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 316274008015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 316274008016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316274008017 catalytic residue [active] 316274008018 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 316274008019 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 316274008020 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 316274008021 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 316274008022 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 316274008023 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 316274008024 putative dimer interface [polypeptide binding]; other site 316274008025 [2Fe-2S] cluster binding site [ion binding]; other site 316274008026 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 316274008027 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 316274008028 SLBB domain; Region: SLBB; pfam10531 316274008029 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316274008030 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 316274008031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274008032 catalytic loop [active] 316274008033 iron binding site [ion binding]; other site 316274008034 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 316274008035 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 316274008036 molybdopterin cofactor binding site; other site 316274008037 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 316274008038 molybdopterin cofactor binding site; other site 316274008039 NADH dehydrogenase; Region: NADHdh; cl00469 316274008040 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274008041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274008042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274008043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008044 NAD(P) binding site [chemical binding]; other site 316274008045 active site 316274008046 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 316274008047 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 316274008048 Response regulator receiver domain; Region: Response_reg; pfam00072 316274008049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008050 active site 316274008051 phosphorylation site [posttranslational modification] 316274008052 intermolecular recognition site; other site 316274008053 dimerization interface [polypeptide binding]; other site 316274008054 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 316274008055 RNA binding site [nucleotide binding]; other site 316274008056 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 316274008057 RNA binding site [nucleotide binding]; other site 316274008058 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 316274008059 RNA binding site [nucleotide binding]; other site 316274008060 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 316274008061 metal ion-dependent adhesion site (MIDAS); other site 316274008062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008063 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 316274008064 Uncharacterized conserved protein [Function unknown]; Region: COG3342 316274008065 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 316274008066 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 316274008067 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 316274008068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274008069 S-adenosylmethionine binding site [chemical binding]; other site 316274008070 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274008071 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 316274008072 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 316274008073 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 316274008074 Moco binding site; other site 316274008075 metal coordination site [ion binding]; other site 316274008076 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008077 GAF domain; Region: GAF; cl00853 316274008078 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008079 GAF domain; Region: GAF; cl00853 316274008080 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008081 GAF domain; Region: GAF; cl00853 316274008082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274008083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274008084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008085 ATP binding site [chemical binding]; other site 316274008086 Mg2+ binding site [ion binding]; other site 316274008087 G-X-G motif; other site 316274008088 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 316274008089 Protein export membrane protein; Region: SecD_SecF; cl14618 316274008090 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 316274008091 Protein export membrane protein; Region: SecD_SecF; cl14618 316274008092 Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a...; Region: M14_CPT; cd03859 316274008093 putative active site [active] 316274008094 Zn-binding site [ion binding]; other site 316274008095 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 316274008096 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 316274008097 serine O-acetyltransferase; Region: cysE; TIGR01172 316274008098 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 316274008099 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 316274008100 trimer interface [polypeptide binding]; other site 316274008101 active site 316274008102 substrate binding site [chemical binding]; other site 316274008103 CoA binding site [chemical binding]; other site 316274008104 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 316274008105 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274008106 active site 316274008107 HIGH motif; other site 316274008108 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274008109 KMSKS motif; other site 316274008110 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 316274008111 tRNA binding surface [nucleotide binding]; other site 316274008112 anticodon binding site; other site 316274008113 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 316274008114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274008115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274008116 S-adenosylmethionine binding site [chemical binding]; other site 316274008117 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 316274008118 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 316274008119 C-terminal peptidase (prc); Region: prc; TIGR00225 316274008120 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316274008121 protein binding site [polypeptide binding]; other site 316274008122 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 316274008123 Catalytic dyad [active] 316274008124 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 316274008125 tyramine oxidase; Provisional; Region: tynA; PRK11504 316274008126 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 316274008127 oligoendopeptidase F; Region: pepF; TIGR00181 316274008128 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 316274008129 active site 316274008130 Zn binding site [ion binding]; other site 316274008131 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274008132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008133 Walker A/P-loop; other site 316274008134 ATP binding site [chemical binding]; other site 316274008135 Q-loop/lid; other site 316274008136 ABC transporter signature motif; other site 316274008137 Walker B; other site 316274008138 D-loop; other site 316274008139 H-loop/switch region; other site 316274008140 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008141 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008142 Integral membrane protein DUF95; Region: DUF95; cl00572 316274008143 recombination factor protein RarA; Reviewed; Region: PRK13342 316274008144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274008145 Walker A motif; other site 316274008146 ATP binding site [chemical binding]; other site 316274008147 Walker B motif; other site 316274008148 arginine finger; other site 316274008149 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 316274008150 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274008151 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274008152 Moco binding site; other site 316274008153 metal coordination site [ion binding]; other site 316274008154 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008155 Isochorismatase family; Region: Isochorismatase; pfam00857 316274008156 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 316274008157 catalytic triad [active] 316274008158 conserved cis-peptide bond; other site 316274008159 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316274008160 FAD binding domain; Region: FAD_binding_4; pfam01565 316274008161 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 316274008162 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274008163 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274008164 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274008165 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274008166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274008168 peptide synthase; Provisional; Region: PRK12467 316274008169 Condensation domain; Region: Condensation; cl09290 316274008170 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274008171 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274008172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274008173 Thioesterase domain; Region: Thioesterase; pfam00975 316274008174 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274008175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008176 putative substrate translocation pore; other site 316274008177 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 316274008178 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 316274008179 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008180 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316274008181 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 316274008182 Walker A/P-loop; other site 316274008183 ATP binding site [chemical binding]; other site 316274008184 Q-loop/lid; other site 316274008185 ABC transporter signature motif; other site 316274008186 Walker B; other site 316274008187 D-loop; other site 316274008188 H-loop/switch region; other site 316274008189 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 316274008190 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 316274008191 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274008192 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274008193 Ligand binding site [chemical binding]; other site 316274008194 Putative Catalytic site [active] 316274008195 DXD motif; other site 316274008196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274008197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274008198 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274008199 putative catalytic residues [active] 316274008200 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 316274008201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008202 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316274008203 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 316274008204 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316274008205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274008206 cytidylate kinase; Provisional; Region: cmk; PRK00023 316274008207 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 316274008208 CMP-binding site; other site 316274008209 The sites determining sugar specificity; other site 316274008210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316274008211 putative acyl-acceptor binding pocket; other site 316274008212 Bacterial membrane flanked domain; Region: DUF304; cl01348 316274008213 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274008214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008215 Walker A/P-loop; other site 316274008216 ATP binding site [chemical binding]; other site 316274008217 Q-loop/lid; other site 316274008218 ABC transporter signature motif; other site 316274008219 Walker B; other site 316274008220 D-loop; other site 316274008221 H-loop/switch region; other site 316274008222 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008224 Response regulator receiver domain; Region: Response_reg; pfam00072 316274008225 active site 316274008226 phosphorylation site [posttranslational modification] 316274008227 intermolecular recognition site; other site 316274008228 dimerization interface [polypeptide binding]; other site 316274008229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274008231 catalytic residues [active] 316274008232 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 316274008233 DNA binding residues [nucleotide binding] 316274008234 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 316274008235 putative dimer interface [polypeptide binding]; other site 316274008236 putative metal binding residues [ion binding]; other site 316274008237 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 316274008238 SpoOM protein; Region: Spo0M; pfam07070 316274008239 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 316274008240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274008241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274008242 catalytic residue [active] 316274008243 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 316274008244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008245 NAD(P) binding site [chemical binding]; other site 316274008246 active site 316274008247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274008248 binding surface 316274008249 TPR motif; other site 316274008250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274008251 binding surface 316274008252 TPR motif; other site 316274008253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274008254 binding surface 316274008255 TPR motif; other site 316274008256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274008257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274008258 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274008259 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274008261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274008262 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274008263 metal ion-dependent adhesion site (MIDAS); other site 316274008264 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274008265 active site 316274008266 ATP binding site [chemical binding]; other site 316274008267 substrate binding site [chemical binding]; other site 316274008268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274008269 activation loop (A-loop); other site 316274008270 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 316274008271 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 316274008272 dihydropteroate synthase; Region: DHPS; TIGR01496 316274008273 substrate binding pocket [chemical binding]; other site 316274008274 dimer interface [polypeptide binding]; other site 316274008275 inhibitor binding site; inhibition site 316274008276 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 316274008277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274008278 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274008279 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 316274008280 NAD+ binding site [chemical binding]; other site 316274008281 substrate binding site [chemical binding]; other site 316274008282 Zn binding site [ion binding]; other site 316274008283 NAD-dependent deacetylase; Provisional; Region: PRK14138 316274008284 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 316274008285 NAD+ binding site [chemical binding]; other site 316274008286 substrate binding site [chemical binding]; other site 316274008287 Zn binding site [ion binding]; other site 316274008288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274008289 active site 316274008290 ATP binding site [chemical binding]; other site 316274008291 activation loop (A-loop); other site 316274008292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274008293 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274008294 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274008295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274008296 catalytic residue [active] 316274008297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274008298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 316274008299 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 316274008300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008301 Walker A/P-loop; other site 316274008302 ATP binding site [chemical binding]; other site 316274008303 Q-loop/lid; other site 316274008304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008305 ABC transporter signature motif; other site 316274008306 Walker B; other site 316274008307 D-loop; other site 316274008308 H-loop/switch region; other site 316274008309 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316274008310 Radical SAM; Region: Elp3; smart00729 316274008311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274008312 FeS/SAM binding site; other site 316274008313 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274008314 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 316274008315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008316 Walker A/P-loop; other site 316274008317 ATP binding site [chemical binding]; other site 316274008318 Q-loop/lid; other site 316274008319 ABC transporter signature motif; other site 316274008320 Walker B; other site 316274008321 D-loop; other site 316274008322 H-loop/switch region; other site 316274008323 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316274008324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 316274008325 substrate binding pocket [chemical binding]; other site 316274008326 membrane-bound complex binding site; other site 316274008327 hinge residues; other site 316274008328 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274008329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274008330 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 316274008331 ParB-like nuclease domain; Region: ParBc; cl02129 316274008332 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274008333 Active site [active] 316274008334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274008335 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274008336 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 316274008337 active site 316274008338 GTP-binding protein LepA; Provisional; Region: PRK05433 316274008339 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 316274008340 G1 box; other site 316274008341 putative GEF interaction site [polypeptide binding]; other site 316274008342 GTP/Mg2+ binding site [chemical binding]; other site 316274008343 Switch I region; other site 316274008344 G2 box; other site 316274008345 G3 box; other site 316274008346 Switch II region; other site 316274008347 G4 box; other site 316274008348 G5 box; other site 316274008349 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 316274008350 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 316274008351 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 316274008352 Protein of unknown function, DUF393; Region: DUF393; cl01136 316274008353 Competence-damaged protein; Region: CinA; cl00666 316274008354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274008355 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 316274008356 active site 316274008357 catalytic triad [active] 316274008358 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274008359 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274008360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274008362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008363 NAD(P) binding site [chemical binding]; other site 316274008364 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274008365 active site 316274008366 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 316274008367 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 316274008368 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 316274008369 nudix motif; other site 316274008370 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 316274008371 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 316274008372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274008373 nucleotide binding region [chemical binding]; other site 316274008374 hypothetical protein; Provisional; Region: PRK10396 316274008375 SEC-C motif; Region: SEC-C; cl12132 316274008376 gamma-glutamyl kinase; Provisional; Region: PRK05429 316274008377 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 316274008378 nucleotide binding site [chemical binding]; other site 316274008379 homotetrameric interface [polypeptide binding]; other site 316274008380 putative phosphate binding site [ion binding]; other site 316274008381 putative allosteric binding site; other site 316274008382 PUA domain; Region: PUA; cl00607 316274008383 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274008384 catalytic core [active] 316274008385 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 316274008386 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 316274008387 putative catalytic cysteine [active] 316274008388 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 316274008389 DNA binding residues [nucleotide binding] 316274008390 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 316274008391 dimer interface [polypeptide binding]; other site 316274008392 metal binding site [ion binding]; metal-binding site 316274008393 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316274008394 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274008395 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274008396 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274008397 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 316274008398 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316274008399 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274008400 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 316274008401 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 316274008402 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 316274008403 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 316274008404 4Fe-4S binding domain; Region: Fer4; cl02805 316274008405 4Fe-4S binding domain; Region: Fer4; cl02805 316274008406 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 316274008407 FOG: WD40-like repeat [Function unknown]; Region: COG1520 316274008408 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 316274008409 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274008410 PAS domain S-box; Region: sensory_box; TIGR00229 316274008411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274008412 putative active site [active] 316274008413 heme pocket [chemical binding]; other site 316274008414 PAS domain S-box; Region: sensory_box; TIGR00229 316274008415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274008416 putative active site [active] 316274008417 heme pocket [chemical binding]; other site 316274008418 GAF domain; Region: GAF; cl00853 316274008419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274008420 Zn2+ binding site [ion binding]; other site 316274008421 Mg2+ binding site [ion binding]; other site 316274008422 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008423 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 316274008424 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 316274008425 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316274008426 active site 316274008427 substrate binding site [chemical binding]; other site 316274008428 catalytic site [active] 316274008429 DEAD_2; Region: DEAD_2; cl14887 316274008430 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 316274008431 Transglycosylase; Region: Transgly; cl07896 316274008432 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 316274008433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 316274008434 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 316274008435 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274008436 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274008437 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 316274008438 protein binding site [polypeptide binding]; other site 316274008439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274008441 TPR motif; other site 316274008442 binding surface 316274008443 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 316274008444 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 316274008445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008446 GAF domain; Region: GAF; cl00853 316274008447 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008448 GAF domain; Region: GAF; cl00853 316274008449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274008450 Histidine kinase; Region: HisKA_2; cl06527 316274008451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008452 ATP binding site [chemical binding]; other site 316274008453 Mg2+ binding site [ion binding]; other site 316274008454 G-X-G motif; other site 316274008455 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274008456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274008457 active site 316274008458 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 316274008459 structural tetrad; other site 316274008460 GTPase Era; Reviewed; Region: era; PRK00089 316274008461 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 316274008462 G1 box; other site 316274008463 GTP/Mg2+ binding site [chemical binding]; other site 316274008464 Switch I region; other site 316274008465 G2 box; other site 316274008466 Switch II region; other site 316274008467 G3 box; other site 316274008468 G4 box; other site 316274008469 G5 box; other site 316274008470 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 316274008471 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274008472 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274008473 Uncharacterized conserved protein [Function unknown]; Region: COG0327 316274008474 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 316274008475 Trm112p-like protein; Region: Trm112p; cl01066 316274008476 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 316274008477 active site 316274008478 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 316274008479 putative metal binding site [ion binding]; other site 316274008480 UbiA prenyltransferase family; Region: UbiA; cl00337 316274008481 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 316274008482 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 316274008483 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 316274008484 NAD(P) binding site [chemical binding]; other site 316274008485 adenylosuccinate lyase; Provisional; Region: PRK09285 316274008486 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 316274008487 tetramer interface [polypeptide binding]; other site 316274008488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274008489 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274008490 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274008491 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274008492 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 316274008493 structural tetrad; other site 316274008494 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274008495 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 316274008496 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 316274008497 NAD binding site [chemical binding]; other site 316274008498 homotetramer interface [polypeptide binding]; other site 316274008499 homodimer interface [polypeptide binding]; other site 316274008500 substrate binding site [chemical binding]; other site 316274008501 active site 316274008502 Predicted esterase [General function prediction only]; Region: COG0627 316274008503 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 316274008504 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 316274008505 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 316274008506 putative dimer interface [polypeptide binding]; other site 316274008507 active site pocket [active] 316274008508 putative cataytic base [active] 316274008509 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274008510 active site 316274008511 catalytic triad [active] 316274008512 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274008513 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008514 ferredoxin-NADP+ reductase; Region: PLN02852 316274008515 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 316274008516 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274008517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274008518 Predicted membrane protein [Function unknown]; Region: COG4270 316274008519 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 316274008520 intersubunit interface [polypeptide binding]; other site 316274008521 active site 316274008522 catalytic residue [active] 316274008523 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 316274008524 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 316274008525 16S rRNA interaction site [nucleotide binding]; other site 316274008526 streptomycin interaction site [chemical binding]; other site 316274008527 23S rRNA interaction site [nucleotide binding]; other site 316274008528 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 316274008529 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 316274008530 elongation factor G; Reviewed; Region: PRK00007 316274008531 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 316274008532 G1 box; other site 316274008533 putative GEF interaction site [polypeptide binding]; other site 316274008534 GTP/Mg2+ binding site [chemical binding]; other site 316274008535 Switch I region; other site 316274008536 G2 box; other site 316274008537 G3 box; other site 316274008538 Switch II region; other site 316274008539 G4 box; other site 316274008540 G5 box; other site 316274008541 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 316274008542 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 316274008543 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 316274008544 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008545 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 316274008546 DNA binding residues [nucleotide binding] 316274008547 putative dimer interface [polypeptide binding]; other site 316274008548 putative metal binding residues [ion binding]; other site 316274008549 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316274008550 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274008551 metal-binding site [ion binding] 316274008552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274008553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274008554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274008555 dimerization interface [polypeptide binding]; other site 316274008556 putative DNA binding site [nucleotide binding]; other site 316274008557 putative Zn2+ binding site [ion binding]; other site 316274008558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274008559 putative DNA binding site [nucleotide binding]; other site 316274008560 dimerization interface [polypeptide binding]; other site 316274008561 putative Zn2+ binding site [ion binding]; other site 316274008562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274008563 active site residue [active] 316274008564 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274008565 active site residue [active] 316274008566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008568 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274008569 putative substrate translocation pore; other site 316274008570 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274008571 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274008572 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 316274008573 FixH; Region: FixH; cl01254 316274008574 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 316274008575 GAF domain; Region: GAF; cl00853 316274008576 sensory histidine kinase AtoS; Provisional; Region: PRK11360 316274008577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274008578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008579 ATP binding site [chemical binding]; other site 316274008580 Mg2+ binding site [ion binding]; other site 316274008581 G-X-G motif; other site 316274008582 Response regulator receiver domain; Region: Response_reg; pfam00072 316274008583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008584 active site 316274008585 phosphorylation site [posttranslational modification] 316274008586 intermolecular recognition site; other site 316274008587 dimerization interface [polypeptide binding]; other site 316274008588 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274008589 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 316274008590 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 316274008591 active site 316274008592 dimerization interface [polypeptide binding]; other site 316274008593 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274008594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008595 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274008596 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 316274008597 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 316274008598 active site 316274008599 catalytic residues [active] 316274008600 metal binding site [ion binding]; metal-binding site 316274008601 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 316274008602 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 316274008603 substrate binding site [chemical binding]; other site 316274008604 ligand binding site [chemical binding]; other site 316274008605 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 316274008606 substrate binding site [chemical binding]; other site 316274008607 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274008608 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 316274008609 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 316274008610 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274008611 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316274008612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008613 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 316274008614 putative nucleotide binding site [chemical binding]; other site 316274008615 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 316274008616 acetylornithine aminotransferase; Provisional; Region: PRK02627 316274008617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274008618 inhibitor-cofactor binding pocket; inhibition site 316274008619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008620 catalytic residue [active] 316274008621 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 316274008622 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 316274008623 metal binding site [ion binding]; metal-binding site 316274008624 putative dimer interface [polypeptide binding]; other site 316274008625 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274008626 active site 316274008627 metal binding site [ion binding]; metal-binding site 316274008628 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 316274008629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274008630 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274008631 active site 316274008632 catalytic site [active] 316274008633 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316274008634 Bacterial SH3 domain; Region: SH3_3; cl02551 316274008635 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 316274008636 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 316274008637 Walker A/P-loop; other site 316274008638 ATP binding site [chemical binding]; other site 316274008639 Q-loop/lid; other site 316274008640 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 316274008641 Q-loop/lid; other site 316274008642 ABC transporter signature motif; other site 316274008643 Walker B; other site 316274008644 D-loop; other site 316274008645 H-loop/switch region; other site 316274008646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274008647 TPR motif; other site 316274008648 binding surface 316274008649 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 316274008650 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 316274008651 Mg++ binding site [ion binding]; other site 316274008652 putative catalytic motif [active] 316274008653 substrate binding site [chemical binding]; other site 316274008654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274008655 nudix motif; other site 316274008656 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 316274008657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 316274008658 Integrase core domain; Region: rve; cl01316 316274008659 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274008660 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274008661 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 316274008662 nudix motif; other site 316274008663 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274008664 classical (c) SDRs; Region: SDR_c; cd05233 316274008665 NAD(P) binding site [chemical binding]; other site 316274008666 active site 316274008667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274008668 dimerization interface [polypeptide binding]; other site 316274008669 putative DNA binding site [nucleotide binding]; other site 316274008670 putative Zn2+ binding site [ion binding]; other site 316274008671 Low molecular weight phosphatase family; Region: LMWPc; cl00105 316274008672 Active site [active] 316274008673 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 316274008674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008675 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316274008676 cysteine synthases; Region: cysKM; TIGR01136 316274008677 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 316274008678 dimer interface [polypeptide binding]; other site 316274008679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008680 catalytic residue [active] 316274008681 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 316274008682 potassium/proton antiporter; Reviewed; Region: PRK05326 316274008683 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274008684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008685 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 316274008686 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274008687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008688 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 316274008689 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274008690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274008691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274008692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008693 ATP binding site [chemical binding]; other site 316274008694 Mg2+ binding site [ion binding]; other site 316274008695 G-X-G motif; other site 316274008696 SEC-C motif; Region: SEC-C; cl12132 316274008697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274008698 DNA binding residues [nucleotide binding] 316274008699 dimerization interface [polypeptide binding]; other site 316274008700 kelch-like protein; Provisional; Region: PHA03098 316274008701 Kelch motif; Region: Kelch_1; cl02701 316274008702 Kelch motif; Region: Kelch_1; cl02701 316274008703 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274008704 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274008705 Sporulation and spore germination; Region: Germane; pfam10646 316274008706 Sporulation and spore germination; Region: Germane; pfam10646 316274008707 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 316274008708 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 316274008709 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 316274008710 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 316274008711 RNA binding site [nucleotide binding]; other site 316274008712 Deoxyhypusine synthase; Region: DS; cl00826 316274008713 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274008714 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316274008715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274008716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008717 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274008718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008719 Walker A/P-loop; other site 316274008720 ATP binding site [chemical binding]; other site 316274008721 Q-loop/lid; other site 316274008722 ABC transporter signature motif; other site 316274008723 Walker B; other site 316274008724 D-loop; other site 316274008725 H-loop/switch region; other site 316274008726 ABC transporter; Region: ABC_tran_2; pfam12848 316274008727 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274008728 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 316274008729 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316274008730 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 316274008731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008732 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 316274008733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008734 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 316274008735 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274008736 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 316274008737 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 316274008738 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 316274008739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274008740 S-adenosylmethionine binding site [chemical binding]; other site 316274008741 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 316274008742 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 316274008743 homodimer interface [polypeptide binding]; other site 316274008744 substrate-cofactor binding pocket; other site 316274008745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008746 catalytic residue [active] 316274008747 EamA-like transporter family; Region: EamA; cl01037 316274008748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274008749 EamA-like transporter family; Region: EamA; cl01037 316274008750 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316274008751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274008752 DNA-binding site [nucleotide binding]; DNA binding site 316274008753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274008754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008755 homodimer interface [polypeptide binding]; other site 316274008756 catalytic residue [active] 316274008757 CHASE3 domain; Region: CHASE3; cl05000 316274008758 PAS fold; Region: PAS; pfam00989 316274008759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274008760 putative active site [active] 316274008761 heme pocket [chemical binding]; other site 316274008762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274008763 dimer interface [polypeptide binding]; other site 316274008764 phosphorylation site [posttranslational modification] 316274008765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008766 ATP binding site [chemical binding]; other site 316274008767 Mg2+ binding site [ion binding]; other site 316274008768 G-X-G motif; other site 316274008769 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 316274008770 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 316274008771 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316274008772 putative acyl-acceptor binding pocket; other site 316274008773 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274008774 Ligand binding site [chemical binding]; other site 316274008775 Putative Catalytic site [active] 316274008776 DXD motif; other site 316274008777 UMP phosphatase; Provisional; Region: PRK10444 316274008778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274008779 active site 316274008780 motif I; other site 316274008781 motif II; other site 316274008782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274008783 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 316274008784 oligomerization interface [polypeptide binding]; other site 316274008785 active site 316274008786 metal binding site [ion binding]; metal-binding site 316274008787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008788 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 316274008789 YhhN-like protein; Region: YhhN; cl01505 316274008790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274008791 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 316274008792 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274008793 transcription termination factor Rho; Provisional; Region: rho; PRK09376 316274008794 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 316274008795 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 316274008796 RNA binding site [nucleotide binding]; other site 316274008797 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 316274008798 multimer interface [polypeptide binding]; other site 316274008799 Walker A motif; other site 316274008800 ATP binding site [chemical binding]; other site 316274008801 Walker B motif; other site 316274008802 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 316274008803 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 316274008804 putative active site [active] 316274008805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274008806 Walker A motif; other site 316274008807 ATP binding site [chemical binding]; other site 316274008808 Walker B motif; other site 316274008809 arginine finger; other site 316274008810 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 316274008811 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 316274008812 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 316274008813 active site 316274008814 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 316274008815 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 316274008816 dimerization interface [polypeptide binding]; other site 316274008817 active site 316274008818 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274008819 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274008820 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 316274008821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274008822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008823 Walker A/P-loop; other site 316274008824 ATP binding site [chemical binding]; other site 316274008825 Q-loop/lid; other site 316274008826 ABC transporter signature motif; other site 316274008827 Walker B; other site 316274008828 D-loop; other site 316274008829 H-loop/switch region; other site 316274008830 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 316274008831 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl10040 316274008832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274008833 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274008834 dimerization interface [polypeptide binding]; other site 316274008835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274008836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274008837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008838 ATP binding site [chemical binding]; other site 316274008839 Mg2+ binding site [ion binding]; other site 316274008840 G-X-G motif; other site 316274008841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274008842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008843 active site 316274008844 phosphorylation site [posttranslational modification] 316274008845 intermolecular recognition site; other site 316274008846 dimerization interface [polypeptide binding]; other site 316274008847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274008848 DNA binding site [nucleotide binding] 316274008849 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 316274008850 dimer interface [polypeptide binding]; other site 316274008851 catalytic triad [active] 316274008852 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274008853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274008854 Probable transposase; Region: OrfB_IS605; pfam01385 316274008855 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 316274008856 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 316274008857 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 316274008858 IHF - DNA interface [nucleotide binding]; other site 316274008859 IHF dimer interface [polypeptide binding]; other site 316274008860 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 316274008861 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274008862 catalytic core [active] 316274008863 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 316274008864 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 316274008865 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 316274008866 FMN binding site [chemical binding]; other site 316274008867 dimer interface [polypeptide binding]; other site 316274008868 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274008870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274008871 active site 316274008872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274008873 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 316274008874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008875 Walker A motif; other site 316274008876 ATP binding site [chemical binding]; other site 316274008877 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 316274008878 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274008879 metal ion-dependent adhesion site (MIDAS); other site 316274008880 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316274008881 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 316274008882 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 316274008883 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 316274008884 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 316274008885 Uncharacterized conserved protein [Function unknown]; Region: COG2308 316274008886 Domain of unknown function (DUF404); Region: DUF404; pfam04169 316274008887 Domain of unknown function (DUF407); Region: DUF407; pfam04174 316274008888 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 316274008889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 316274008890 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274008891 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274008892 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 316274008893 dimer interface [polypeptide binding]; other site 316274008894 putative metal binding site [ion binding]; other site 316274008895 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316274008896 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274008897 active site 316274008898 Substrate binding site [chemical binding]; other site 316274008899 Mg++ binding site [ion binding]; other site 316274008900 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274008901 putative trimer interface [polypeptide binding]; other site 316274008902 putative CoA binding site [chemical binding]; other site 316274008903 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 316274008904 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 316274008905 septum formation inhibitor; Reviewed; Region: minC; PRK00513 316274008906 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 316274008907 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 316274008908 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 316274008909 Switch I; other site 316274008910 Switch II; other site 316274008911 Septum formation topological specificity factor MinE; Region: MinE; cl00538 316274008912 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274008913 Domain of unknown function DUF20; Region: UPF0118; cl00465 316274008914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274008915 metal binding site [ion binding]; metal-binding site 316274008916 active site 316274008917 I-site; other site 316274008918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274008919 Walker A motif; other site 316274008920 ATP binding site [chemical binding]; other site 316274008921 Walker B motif; other site 316274008922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008923 Protein of unknown function (DUF461); Region: DUF461; cl01071 316274008924 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 316274008925 Cu(I) binding site [ion binding]; other site 316274008926 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316274008927 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274008928 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316274008929 putative active site [active] 316274008930 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 316274008931 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 316274008932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274008933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274008934 DNA binding residues [nucleotide binding] 316274008935 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 316274008936 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 316274008937 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 316274008938 ATP-binding site [chemical binding]; other site 316274008939 Uncharacterized conserved protein [Function unknown]; Region: COG4715 316274008940 ski2-like helicase; Provisional; Region: PRK01172 316274008941 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 316274008942 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274008943 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 316274008944 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 316274008945 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 316274008946 G1 box; other site 316274008947 GTP/Mg2+ binding site [chemical binding]; other site 316274008948 Switch I region; other site 316274008949 G2 box; other site 316274008950 Switch II region; other site 316274008951 G3 box; other site 316274008952 G4 box; other site 316274008953 G5 box; other site 316274008954 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 316274008955 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008956 Acylphosphatase; Region: Acylphosphatase; cl00551 316274008957 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274008958 conserved cys residue [active] 316274008959 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274008960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274008961 dimer interface [polypeptide binding]; other site 316274008962 conserved gate region; other site 316274008963 putative PBP binding loops; other site 316274008964 ABC-ATPase subunit interface; other site 316274008965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274008966 dimer interface [polypeptide binding]; other site 316274008967 conserved gate region; other site 316274008968 putative PBP binding loops; other site 316274008969 ABC-ATPase subunit interface; other site 316274008970 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274008971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274008972 dimer interface [polypeptide binding]; other site 316274008973 phosphorylation site [posttranslational modification] 316274008974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008975 ATP binding site [chemical binding]; other site 316274008976 Mg2+ binding site [ion binding]; other site 316274008977 G-X-G motif; other site 316274008978 Response regulator receiver domain; Region: Response_reg; pfam00072 316274008979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008980 active site 316274008981 phosphorylation site [posttranslational modification] 316274008982 intermolecular recognition site; other site 316274008983 dimerization interface [polypeptide binding]; other site 316274008984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274008985 active site 316274008986 phosphorylation site [posttranslational modification] 316274008987 intermolecular recognition site; other site 316274008988 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316274008989 putative active site [active] 316274008990 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274008991 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274008992 catalytic site [active] 316274008993 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 316274008994 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 316274008995 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316274008996 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 316274008997 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 316274008998 catalytic residues [active] 316274008999 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 316274009000 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 316274009001 active site 316274009002 metal binding site [ion binding]; metal-binding site 316274009003 DNA binding site [nucleotide binding] 316274009004 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 316274009005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274009006 domain; Region: Succ_DH_flav_C; pfam02910 316274009007 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 316274009008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274009009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316274009010 dimerization interface [polypeptide binding]; other site 316274009011 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 316274009012 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274009014 active site 316274009015 phosphorylation site [posttranslational modification] 316274009016 intermolecular recognition site; other site 316274009017 dimerization interface [polypeptide binding]; other site 316274009018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009019 GAF domain; Region: GAF; cl00853 316274009020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009021 GAF domain; Region: GAF; cl00853 316274009022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274009023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274009024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274009025 dimer interface [polypeptide binding]; other site 316274009026 phosphorylation site [posttranslational modification] 316274009027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009028 ATP binding site [chemical binding]; other site 316274009029 Mg2+ binding site [ion binding]; other site 316274009030 G-X-G motif; other site 316274009031 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274009033 active site 316274009034 phosphorylation site [posttranslational modification] 316274009035 intermolecular recognition site; other site 316274009036 dimerization interface [polypeptide binding]; other site 316274009037 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009038 GAF domain; Region: GAF; cl00853 316274009039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274009040 dimer interface [polypeptide binding]; other site 316274009041 phosphorylation site [posttranslational modification] 316274009042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009043 ATP binding site [chemical binding]; other site 316274009044 Mg2+ binding site [ion binding]; other site 316274009045 G-X-G motif; other site 316274009046 pantoate--beta-alanine ligase; Region: panC; TIGR00018 316274009047 Pantoate-beta-alanine ligase; Region: PanC; cd00560 316274009048 active site 316274009049 ATP-binding site [chemical binding]; other site 316274009050 pantoate-binding site; other site 316274009051 HXXH motif; other site 316274009052 Cellulose binding domain; Region: CBM_2; cl02709 316274009053 Pectate lyase; Region: Pec_lyase_C; cl01593 316274009054 Cellulose binding domain; Region: CBM_2; cl02709 316274009055 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 316274009056 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 316274009057 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 316274009058 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 316274009059 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274009060 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274009061 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 316274009062 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 316274009063 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 316274009064 substrate binding site [chemical binding]; other site 316274009065 ATP binding site [chemical binding]; other site 316274009066 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274009068 active site 316274009069 phosphorylation site [posttranslational modification] 316274009070 intermolecular recognition site; other site 316274009071 dimerization interface [polypeptide binding]; other site 316274009072 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274009073 metal binding site [ion binding]; metal-binding site 316274009074 active site 316274009075 I-site; other site 316274009076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009077 binding surface 316274009078 TPR motif; other site 316274009079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009080 binding surface 316274009081 TPR motif; other site 316274009082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009083 binding surface 316274009084 TPR motif; other site 316274009085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009086 binding surface 316274009087 TPR motif; other site 316274009088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009089 binding surface 316274009090 TPR motif; other site 316274009091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009092 binding surface 316274009093 TPR motif; other site 316274009094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009095 binding surface 316274009096 TPR motif; other site 316274009097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274009098 acyl-coenzyme A oxidase; Region: PLN02526 316274009099 active site 316274009100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274009101 S-adenosylmethionine binding site [chemical binding]; other site 316274009102 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009103 active site 316274009104 ATP binding site [chemical binding]; other site 316274009105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009106 substrate binding site [chemical binding]; other site 316274009107 activation loop (A-loop); other site 316274009108 large tegument protein UL36; Provisional; Region: PHA03247 316274009109 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274009110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009111 binding surface 316274009112 TPR motif; other site 316274009113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009114 TPR motif; other site 316274009115 binding surface 316274009116 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 316274009117 active site 316274009118 catalytic residues [active] 316274009119 metal binding site [ion binding]; metal-binding site 316274009120 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274009121 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274009122 transcriptional regulator MalT; Provisional; Region: PRK04841 316274009123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274009124 DNA binding residues [nucleotide binding] 316274009125 dimerization interface [polypeptide binding]; other site 316274009126 GMP synthase; Reviewed; Region: guaA; PRK00074 316274009127 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 316274009128 AMP/PPi binding site [chemical binding]; other site 316274009129 candidate oxyanion hole; other site 316274009130 catalytic triad [active] 316274009131 potential glutamine specificity residues [chemical binding]; other site 316274009132 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 316274009133 ATP Binding subdomain [chemical binding]; other site 316274009134 Ligand Binding sites [chemical binding]; other site 316274009135 Dimerization subdomain; other site 316274009136 Predicted membrane protein [Function unknown]; Region: COG2860 316274009137 UPF0126 domain; Region: UPF0126; pfam03458 316274009138 UPF0126 domain; Region: UPF0126; pfam03458 316274009139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274009140 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274009141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009142 active site 316274009143 ATP binding site [chemical binding]; other site 316274009144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009145 substrate binding site [chemical binding]; other site 316274009146 activation loop (A-loop); other site 316274009147 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009148 active site 316274009149 ATP binding site [chemical binding]; other site 316274009150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009151 substrate binding site [chemical binding]; other site 316274009152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274009153 substrate binding site [chemical binding]; other site 316274009154 activation loop (A-loop); other site 316274009155 activation loop (A-loop); other site 316274009156 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 316274009157 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274009158 DinB superfamily; Region: DinB_2; cl00986 316274009159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274009160 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 316274009161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274009162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274009163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274009164 Coenzyme A binding pocket [chemical binding]; other site 316274009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274009166 S-adenosylmethionine binding site [chemical binding]; other site 316274009167 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 316274009168 active site 316274009169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274009170 ScpA/B protein; Region: ScpA_ScpB; cl00598 316274009171 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 316274009172 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 316274009173 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 316274009174 NAD(P) binding site [chemical binding]; other site 316274009175 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 316274009176 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274009177 peptide binding site [polypeptide binding]; other site 316274009178 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274009179 dimer interface [polypeptide binding]; other site 316274009180 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 316274009181 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274009182 Walker A/P-loop; other site 316274009183 ATP binding site [chemical binding]; other site 316274009184 Q-loop/lid; other site 316274009185 ABC transporter signature motif; other site 316274009186 Walker B; other site 316274009187 D-loop; other site 316274009188 H-loop/switch region; other site 316274009189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274009190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274009191 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 316274009192 Walker A/P-loop; other site 316274009193 ATP binding site [chemical binding]; other site 316274009194 Q-loop/lid; other site 316274009195 ABC transporter signature motif; other site 316274009196 Walker B; other site 316274009197 D-loop; other site 316274009198 H-loop/switch region; other site 316274009199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274009200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274009201 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274009202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274009203 dimer interface [polypeptide binding]; other site 316274009204 conserved gate region; other site 316274009205 putative PBP binding loops; other site 316274009206 ABC-ATPase subunit interface; other site 316274009207 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274009208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274009209 dimer interface [polypeptide binding]; other site 316274009210 conserved gate region; other site 316274009211 putative PBP binding loops; other site 316274009212 ABC-ATPase subunit interface; other site 316274009213 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274009214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274009215 peptide binding site [polypeptide binding]; other site 316274009216 dimer interface [polypeptide binding]; other site 316274009217 cell division protein FtsZ; Validated; Region: PRK09330 316274009218 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 316274009219 nucleotide binding site [chemical binding]; other site 316274009220 SulA interaction site; other site 316274009221 cell division protein FtsA; Region: ftsA; TIGR01174 316274009222 Cell division protein FtsA; Region: FtsA; cl11496 316274009223 Cell division protein FtsA; Region: FtsA; cl11496 316274009224 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 316274009225 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 316274009226 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 316274009227 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 316274009228 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274009229 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 316274009230 FAD binding domain; Region: FAD_binding_4; pfam01565 316274009231 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 316274009232 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274009233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009234 binding surface 316274009235 TPR motif; other site 316274009236 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 316274009237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274009238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274009239 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 316274009240 homodimer interface [polypeptide binding]; other site 316274009241 active site 316274009242 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 316274009243 Rhomboid family; Region: Rhomboid; cl11446 316274009244 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 316274009245 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274009246 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 316274009247 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 316274009248 Mg++ binding site [ion binding]; other site 316274009249 putative catalytic motif [active] 316274009250 putative substrate binding site [chemical binding]; other site 316274009251 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 316274009252 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274009253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274009254 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274009255 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 316274009256 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274009257 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 316274009258 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 316274009259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274009260 cell division protein MraZ; Reviewed; Region: PRK00326 316274009261 MraZ protein; Region: MraZ; pfam02381 316274009262 MraZ protein; Region: MraZ; pfam02381 316274009263 MASE1; Region: MASE1; pfam05231 316274009264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009265 GAF domain; Region: GAF; cl00853 316274009266 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009267 GAF domain; Region: GAF; cl00853 316274009268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274009269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274009270 dimer interface [polypeptide binding]; other site 316274009271 phosphorylation site [posttranslational modification] 316274009272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009273 ATP binding site [chemical binding]; other site 316274009274 Mg2+ binding site [ion binding]; other site 316274009275 G-X-G motif; other site 316274009276 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274009278 active site 316274009279 phosphorylation site [posttranslational modification] 316274009280 intermolecular recognition site; other site 316274009281 dimerization interface [polypeptide binding]; other site 316274009282 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 316274009283 putative active site [active] 316274009284 Domain of unknown function (DU1801); Region: DUF1801; cl01838 316274009285 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316274009286 Phosphotransferase enzyme family; Region: APH; pfam01636 316274009287 active site 316274009288 substrate binding site [chemical binding]; other site 316274009289 ATP binding site [chemical binding]; other site 316274009290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274009291 PAS fold; Region: PAS_4; pfam08448 316274009292 hypothetical protein; Provisional; Region: PRK13560 316274009293 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274009294 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009295 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 316274009296 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 316274009297 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 316274009298 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 316274009299 HK022 subfamily; Region: phage_DnaB; TIGR03600 316274009300 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 316274009301 Walker A motif; other site 316274009302 ATP binding site [chemical binding]; other site 316274009303 Walker B motif; other site 316274009304 DNA binding loops [nucleotide binding] 316274009305 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 316274009306 protein-splicing catalytic site; other site 316274009307 thioester formation/cholesterol transfer; other site 316274009308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009309 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274009310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274009311 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 316274009312 Divergent AAA domain; Region: AAA_4; pfam04326 316274009313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316274009314 putative acyl-acceptor binding pocket; other site 316274009315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274009316 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 316274009317 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274009318 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 316274009319 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 316274009320 homodimer interface [polypeptide binding]; other site 316274009321 NAD binding site [chemical binding]; other site 316274009322 catalytic residues [active] 316274009323 substrate binding pocket [chemical binding]; other site 316274009324 flexible flap; other site 316274009325 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274009326 active site 316274009327 catalytic triad [active] 316274009328 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 316274009329 DNA binding residues [nucleotide binding] 316274009330 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 316274009331 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 316274009332 tRNA; other site 316274009333 putative tRNA binding site [nucleotide binding]; other site 316274009334 putative NADP binding site [chemical binding]; other site 316274009335 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 316274009336 Chlorite dismutase; Region: Chlor_dismutase; cl01280 316274009337 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 316274009338 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 316274009339 substrate binding site [chemical binding]; other site 316274009340 active site 316274009341 Ferrochelatase; Region: Ferrochelatase; pfam00762 316274009342 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 316274009343 C-terminal domain interface [polypeptide binding]; other site 316274009344 active site 316274009345 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 316274009346 active site 316274009347 N-terminal domain interface [polypeptide binding]; other site 316274009348 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 316274009349 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 316274009350 domain interfaces; other site 316274009351 active site 316274009352 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 316274009353 active site 316274009354 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 316274009355 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 316274009356 dimer interface [polypeptide binding]; other site 316274009357 active site 316274009358 Schiff base residues; other site 316274009359 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 316274009360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274009361 inhibitor-cofactor binding pocket; inhibition site 316274009362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274009363 catalytic residue [active] 316274009364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274009365 putative catalytic site [active] 316274009366 putative metal binding site [ion binding]; other site 316274009367 putative phosphate binding site [ion binding]; other site 316274009368 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274009369 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316274009370 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274009371 motif 1; other site 316274009372 dimer interface [polypeptide binding]; other site 316274009373 active site 316274009374 motif 2; other site 316274009375 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 316274009376 putative deacylase active site [active] 316274009377 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274009378 active site 316274009379 motif 3; other site 316274009380 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 316274009381 anticodon binding site; other site 316274009382 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 316274009383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009384 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274009385 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274009386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274009387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274009388 active site 316274009389 GTP-binding protein Der; Reviewed; Region: PRK00093 316274009390 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 316274009391 G1 box; other site 316274009392 GTP/Mg2+ binding site [chemical binding]; other site 316274009393 Switch I region; other site 316274009394 G2 box; other site 316274009395 Switch II region; other site 316274009396 G3 box; other site 316274009397 G4 box; other site 316274009398 G5 box; other site 316274009399 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 316274009400 G1 box; other site 316274009401 GTP/Mg2+ binding site [chemical binding]; other site 316274009402 Switch I region; other site 316274009403 G2 box; other site 316274009404 G3 box; other site 316274009405 Switch II region; other site 316274009406 G4 box; other site 316274009407 G5 box; other site 316274009408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274009409 GAF domain; Region: GAF; cl00853 316274009410 GAF domain; Region: GAF; cl00853 316274009411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274009412 Zn2+ binding site [ion binding]; other site 316274009413 Mg2+ binding site [ion binding]; other site 316274009414 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 316274009415 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 316274009416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 316274009417 Protein of unknown function (DUF512); Region: DUF512; pfam04459 316274009418 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 316274009419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274009420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274009421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274009422 metal binding site [ion binding]; metal-binding site 316274009423 active site 316274009424 I-site; other site 316274009425 Bacterial sugar transferase; Region: Bac_transf; cl00939 316274009426 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 316274009427 putative ADP-binding pocket [chemical binding]; other site 316274009428 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274009429 Chain length determinant protein; Region: Wzz; cl01623 316274009430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274009431 active site 316274009432 I-site; other site 316274009433 metal binding site [ion binding]; metal-binding site 316274009434 O-Antigen ligase; Region: Wzy_C; cl04850 316274009435 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274009436 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 316274009437 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274009438 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 316274009439 putative ADP-binding pocket [chemical binding]; other site 316274009440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274009441 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274009442 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 316274009443 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274009444 DXD motif; other site 316274009445 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274009446 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274009447 active site 316274009448 dimer interface [polypeptide binding]; other site 316274009449 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 316274009450 Ligand Binding Site [chemical binding]; other site 316274009451 Molecular Tunnel; other site 316274009452 cellulose synthase regulator protein; Provisional; Region: PRK11114 316274009453 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 316274009454 Double zinc ribbon; Region: DZR; pfam12773 316274009455 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274009456 cyclase homology domain; Region: CHD; cd07302 316274009457 nucleotidyl binding site; other site 316274009458 metal binding site [ion binding]; metal-binding site 316274009459 dimer interface [polypeptide binding]; other site 316274009460 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274009461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009462 binding surface 316274009463 TPR motif; other site 316274009464 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 316274009465 active site 316274009466 catalytic triad [active] 316274009467 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274009468 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274009469 putative active site [active] 316274009470 putative metal binding site [ion binding]; other site 316274009471 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 316274009472 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316274009473 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 316274009474 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316274009475 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274009476 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274009477 active site 316274009478 NlpC/P60 family; Region: NLPC_P60; cl11438 316274009479 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 316274009480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009481 Walker A/P-loop; other site 316274009482 ATP binding site [chemical binding]; other site 316274009483 Q-loop/lid; other site 316274009484 ABC transporter signature motif; other site 316274009485 Walker B; other site 316274009486 D-loop; other site 316274009487 H-loop/switch region; other site 316274009488 GTPase RsgA; Reviewed; Region: PRK00098 316274009489 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 316274009490 GTPase/OB domain interface [polypeptide binding]; other site 316274009491 GTPase/Zn-binding domain interface [polypeptide binding]; other site 316274009492 GTP/Mg2+ binding site [chemical binding]; other site 316274009493 G4 box; other site 316274009494 G5 box; other site 316274009495 G1 box; other site 316274009496 Switch I region; other site 316274009497 G2 box; other site 316274009498 G3 box; other site 316274009499 Switch II region; other site 316274009500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274009501 Walker A motif; other site 316274009502 ATP binding site [chemical binding]; other site 316274009503 Walker B motif; other site 316274009504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274009505 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 316274009506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274009507 catalytic core [active] 316274009508 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 316274009509 active site 316274009510 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274009511 active site clefts [active] 316274009512 zinc binding site [ion binding]; other site 316274009513 dimer interface [polypeptide binding]; other site 316274009514 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274009515 active site clefts [active] 316274009516 zinc binding site [ion binding]; other site 316274009517 dimer interface [polypeptide binding]; other site 316274009518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274009519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274009520 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 316274009521 catalytic residues [active] 316274009522 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 316274009523 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274009524 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274009525 AzlC protein; Region: AzlC; cl00570 316274009526 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 316274009527 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 316274009528 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274009529 dimerization interface [polypeptide binding]; other site 316274009530 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274009532 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 316274009533 RecD/TraA family; Region: recD_rel; TIGR01448 316274009534 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274009535 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 316274009536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274009537 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 316274009538 Cupin domain; Region: Cupin_2; cl09118 316274009539 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 316274009540 putative metal binding site [ion binding]; other site 316274009541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274009542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 316274009543 CoA-transferase family III; Region: CoA_transf_3; cl00778 316274009544 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274009545 GtrA-like protein; Region: GtrA; cl00971 316274009546 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274009547 Ligand binding site [chemical binding]; other site 316274009548 Putative Catalytic site [active] 316274009549 DXD motif; other site 316274009550 DinB superfamily; Region: DinB_2; cl00986 316274009551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274009552 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274009553 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 316274009554 Walker A/P-loop; other site 316274009555 ATP binding site [chemical binding]; other site 316274009556 Q-loop/lid; other site 316274009557 ABC transporter signature motif; other site 316274009558 Walker B; other site 316274009559 D-loop; other site 316274009560 H-loop/switch region; other site 316274009561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274009562 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274009563 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 316274009564 Walker A/P-loop; other site 316274009565 ATP binding site [chemical binding]; other site 316274009566 Q-loop/lid; other site 316274009567 ABC transporter signature motif; other site 316274009568 Walker B; other site 316274009569 D-loop; other site 316274009570 H-loop/switch region; other site 316274009571 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274009572 TM1410 hypothetical-related protein; Region: DUF297; cl00997 316274009573 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 316274009574 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 316274009575 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 316274009576 FAD binding site [chemical binding]; other site 316274009577 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 316274009578 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 316274009579 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 316274009580 motif 1; other site 316274009581 active site 316274009582 motif 2; other site 316274009583 motif 3; other site 316274009584 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 316274009585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274009586 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 316274009587 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 316274009588 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 316274009589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274009590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274009591 dimer interface [polypeptide binding]; other site 316274009592 conserved gate region; other site 316274009593 putative PBP binding loops; other site 316274009594 ABC-ATPase subunit interface; other site 316274009595 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 316274009596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274009597 dimer interface [polypeptide binding]; other site 316274009598 conserved gate region; other site 316274009599 putative PBP binding loops; other site 316274009600 ABC-ATPase subunit interface; other site 316274009601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274009602 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274009603 active site 316274009604 substrate binding site [chemical binding]; other site 316274009605 Mg2+ binding site [ion binding]; other site 316274009606 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 316274009607 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 316274009608 active site 316274009609 Zn binding site [ion binding]; other site 316274009610 Competence protein; Region: Competence; cl00471 316274009611 Cupin domain; Region: Cupin_2; cl09118 316274009612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 316274009613 Bacterial SH3 domain; Region: SH3_3; cl02551 316274009614 NlpC/P60 family; Region: NLPC_P60; cl11438 316274009615 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009616 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 316274009617 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274009618 Uncharacterized conserved protein [Function unknown]; Region: COG1912 316274009619 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 316274009620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274009621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274009622 active site 316274009623 phosphorylation site [posttranslational modification] 316274009624 intermolecular recognition site; other site 316274009625 dimerization interface [polypeptide binding]; other site 316274009626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274009627 DNA binding residues [nucleotide binding] 316274009628 dimerization interface [polypeptide binding]; other site 316274009629 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274009630 putative ligand binding site [chemical binding]; other site 316274009631 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 316274009632 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 316274009633 Walker A/P-loop; other site 316274009634 ATP binding site [chemical binding]; other site 316274009635 Q-loop/lid; other site 316274009636 ABC transporter signature motif; other site 316274009637 Walker B; other site 316274009638 D-loop; other site 316274009639 H-loop/switch region; other site 316274009640 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 316274009641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274009642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274009643 TM-ABC transporter signature motif; other site 316274009644 ribulokinase; Provisional; Region: PRK04123 316274009645 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274009646 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 316274009647 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 316274009648 intersubunit interface [polypeptide binding]; other site 316274009649 active site 316274009650 Zn2+ binding site [ion binding]; other site 316274009651 L-arabinose isomerase; Provisional; Region: PRK02929 316274009652 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 316274009653 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 316274009654 trimer interface [polypeptide binding]; other site 316274009655 putative substrate binding site [chemical binding]; other site 316274009656 putative metal binding site [ion binding]; other site 316274009657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274009658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274009659 DNA binding site [nucleotide binding] 316274009660 domain linker motif; other site 316274009661 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274009662 putative dimerization interface [polypeptide binding]; other site 316274009663 putative ligand binding site [chemical binding]; other site 316274009664 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 316274009665 aspartate aminotransferase; Provisional; Region: PRK06836 316274009666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274009667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274009668 homodimer interface [polypeptide binding]; other site 316274009669 catalytic residue [active] 316274009670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274009671 catalytic core [active] 316274009672 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009673 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 316274009674 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274009675 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 316274009676 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274009677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274009678 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 316274009679 oligomerisation interface [polypeptide binding]; other site 316274009680 mobile loop; other site 316274009681 roof hairpin; other site 316274009682 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 316274009683 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 316274009684 ring oligomerisation interface [polypeptide binding]; other site 316274009685 ATP/Mg binding site [chemical binding]; other site 316274009686 stacking interactions; other site 316274009687 hinge regions; other site 316274009688 dihydrodipicolinate reductase; Provisional; Region: PRK00048 316274009689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009690 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 316274009691 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274009692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 316274009693 Predicted ATPase [General function prediction only]; Region: COG3899 316274009694 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 316274009695 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274009696 Predicted ATPase [General function prediction only]; Region: COG3899 316274009697 DinB superfamily; Region: DinB_2; cl00986 316274009698 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 316274009699 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274009700 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274009702 ligand binding site [chemical binding]; other site 316274009703 flexible hinge region; other site 316274009704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274009705 ligand binding site [chemical binding]; other site 316274009706 flexible hinge region; other site 316274009707 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 316274009708 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316274009709 Putative esterase; Region: Esterase; pfam00756 316274009710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274009711 Flavin Reductases; Region: FlaRed; cl00801 316274009712 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316274009713 MatE; Region: MatE; pfam01554 316274009714 MatE; Region: MatE; pfam01554 316274009715 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 316274009716 Cytochrome P450; Region: p450; cl12078 316274009717 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 316274009718 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 316274009719 Sporulation and spore germination; Region: Germane; pfam10646 316274009720 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 316274009721 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 316274009722 active site 316274009723 HIGH motif; other site 316274009724 dimer interface [polypeptide binding]; other site 316274009725 KMSKS motif; other site 316274009726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 316274009727 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 316274009728 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 316274009729 PUA domain; Region: PUA; cl00607 316274009730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274009731 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group...; Region: DmpA_OAT; cl00603 316274009732 active site pocket [active] 316274009733 Found in ATP-dependent protease La (LON); Region: LON; cl01056 316274009734 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316274009735 Protein of unknown function (DUF503); Region: DUF503; cl00669 316274009736 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 316274009737 maltodextrin glucosidase; Provisional; Region: PRK10785 316274009738 homodimer; other site 316274009739 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274009740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274009741 UbiA prenyltransferase family; Region: UbiA; cl00337 316274009742 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274009743 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274009744 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274009745 active site 316274009746 dimer interface [polypeptide binding]; other site 316274009747 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 316274009748 Ligand Binding Site [chemical binding]; other site 316274009749 Molecular Tunnel; other site 316274009750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274009751 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274009752 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274009753 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316274009754 RNA binding site [nucleotide binding]; other site 316274009755 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316274009756 RNA binding site [nucleotide binding]; other site 316274009757 30S ribosomal protein S1; Reviewed; Region: PRK07400 316274009758 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 316274009759 RNA binding site [nucleotide binding]; other site 316274009760 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274009761 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 316274009762 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 316274009763 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316274009764 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 316274009765 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 316274009766 dimer interface [polypeptide binding]; other site 316274009767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274009768 catalytic residue [active] 316274009769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 316274009770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274009771 S-adenosylmethionine binding site [chemical binding]; other site 316274009772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009773 active site 316274009774 ATP binding site [chemical binding]; other site 316274009775 substrate binding site [chemical binding]; other site 316274009776 activation loop (A-loop); other site 316274009777 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 316274009778 recombination protein F; Reviewed; Region: recF; PRK00064 316274009779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009780 Walker A/P-loop; other site 316274009781 ATP binding site [chemical binding]; other site 316274009782 Q-loop/lid; other site 316274009783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009784 Q-loop/lid; other site 316274009785 ABC transporter signature motif; other site 316274009786 Walker B; other site 316274009787 D-loop; other site 316274009788 H-loop/switch region; other site 316274009789 Beta-lactamase; Region: Beta-lactamase; cl01009 316274009790 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 316274009791 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 316274009792 MBOAT family; Region: MBOAT; cl00738 316274009793 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 316274009794 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274009795 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274009796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 316274009797 MOSC domain; Region: MOSC; pfam03473 316274009798 3-alpha domain; Region: 3-alpha; pfam03475 316274009799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274009800 Coenzyme A binding pocket [chemical binding]; other site 316274009801 IKI3 family; Region: IKI3; pfam04762 316274009802 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274009803 Cytochrome c; Region: Cytochrom_C; cl11414 316274009804 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274009805 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 316274009806 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 316274009807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274009808 non-specific DNA binding site [nucleotide binding]; other site 316274009809 salt bridge; other site 316274009810 sequence-specific DNA binding site [nucleotide binding]; other site 316274009811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274009813 binding surface 316274009814 TPR motif; other site 316274009815 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 316274009816 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274009817 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 316274009818 putative active site [active] 316274009819 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274009820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009821 Walker A/P-loop; other site 316274009822 ATP binding site [chemical binding]; other site 316274009823 Q-loop/lid; other site 316274009824 ABC transporter signature motif; other site 316274009825 Walker B; other site 316274009826 D-loop; other site 316274009827 H-loop/switch region; other site 316274009828 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274009829 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274009830 NADP-binding site; other site 316274009831 homotetramer interface [polypeptide binding]; other site 316274009832 substrate binding site [chemical binding]; other site 316274009833 homodimer interface [polypeptide binding]; other site 316274009834 active site 316274009835 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 316274009836 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 316274009837 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274009838 ligand binding site [chemical binding]; other site 316274009839 flexible hinge region; other site 316274009840 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274009841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009842 Walker A/P-loop; other site 316274009843 ATP binding site [chemical binding]; other site 316274009844 Q-loop/lid; other site 316274009845 ABC transporter signature motif; other site 316274009846 Walker B; other site 316274009847 D-loop; other site 316274009848 H-loop/switch region; other site 316274009849 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 316274009850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009851 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274009852 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 316274009853 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 316274009854 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274009855 DRTGG domain; Region: DRTGG; cl12147 316274009856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009857 NAD(P) binding site [chemical binding]; other site 316274009858 active site 316274009859 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 316274009860 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274009861 DNA binding site [nucleotide binding] 316274009862 active site 316274009863 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 316274009864 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 316274009865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274009866 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 316274009867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274009868 minor groove reading motif; other site 316274009869 helix-hairpin-helix signature motif; other site 316274009870 substrate binding pocket [chemical binding]; other site 316274009871 active site 316274009872 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 316274009873 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 316274009874 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 316274009875 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 316274009876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274009877 Walker A/P-loop; other site 316274009878 ATP binding site [chemical binding]; other site 316274009879 Q-loop/lid; other site 316274009880 ABC transporter signature motif; other site 316274009881 Walker B; other site 316274009882 D-loop; other site 316274009883 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316274009884 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 316274009885 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 316274009886 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 316274009887 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 316274009888 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 316274009889 catalytic residues [active] 316274009890 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 316274009891 Cytochrome c; Region: Cytochrom_C; cl11414 316274009892 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 316274009893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274009894 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274009895 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274009896 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274009897 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274009898 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274009899 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274009900 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274009901 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 316274009902 putative active site [active] 316274009903 catalytic triad [active] 316274009904 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 316274009905 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 316274009906 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 316274009907 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 316274009908 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 316274009909 dimerization interface [polypeptide binding]; other site 316274009910 ATP binding site [chemical binding]; other site 316274009911 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 316274009912 dimerization interface [polypeptide binding]; other site 316274009913 ATP binding site [chemical binding]; other site 316274009914 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 316274009915 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316274009916 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 316274009917 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 316274009918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009919 GAF domain; Region: GAF; cl00853 316274009920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274009921 Histidine kinase; Region: HisKA_3; pfam07730 316274009922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009923 ATP binding site [chemical binding]; other site 316274009924 Mg2+ binding site [ion binding]; other site 316274009925 G-X-G motif; other site 316274009926 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 316274009927 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 316274009928 MOSC domain; Region: MOSC; pfam03473 316274009929 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 316274009930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274009931 catalytic core [active] 316274009932 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274009933 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274009934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274009935 catalytic residue [active] 316274009936 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 316274009937 Iron-sulfur protein interface; other site 316274009938 proximal heme binding site [chemical binding]; other site 316274009939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274009940 FAD binding domain; Region: FAD_binding_2; pfam00890 316274009941 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 316274009942 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 316274009943 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316274009944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274009945 NAD(P) binding site [chemical binding]; other site 316274009946 catalytic residues [active] 316274009947 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 316274009948 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 316274009949 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 316274009950 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 316274009951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274009952 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 316274009953 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274009954 NAD(P) binding site [chemical binding]; other site 316274009955 catalytic residues [active] 316274009956 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316274009957 NAD(P) binding site [chemical binding]; other site 316274009958 catalytic residues [active] 316274009959 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 316274009960 Ferritin-like domain; Region: Ferritin; pfam00210 316274009961 ferroxidase diiron center [ion binding]; other site 316274009962 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 316274009963 dimer interaction site [polypeptide binding]; other site 316274009964 substrate-binding tunnel; other site 316274009965 active site 316274009966 catalytic site [active] 316274009967 substrate binding site [chemical binding]; other site 316274009968 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316274009969 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274009970 hypothetical protein; Validated; Region: PRK06840 316274009971 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 316274009972 active site 316274009973 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274009974 TM-ABC transporter signature motif; other site 316274009975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274009976 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274009977 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274009978 TM-ABC transporter signature motif; other site 316274009979 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 316274009980 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 316274009981 Walker A/P-loop; other site 316274009982 ATP binding site [chemical binding]; other site 316274009983 Q-loop/lid; other site 316274009984 ABC transporter signature motif; other site 316274009985 Walker B; other site 316274009986 D-loop; other site 316274009987 H-loop/switch region; other site 316274009988 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274009989 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 316274009990 Walker A/P-loop; other site 316274009991 ATP binding site [chemical binding]; other site 316274009992 Q-loop/lid; other site 316274009993 ABC transporter signature motif; other site 316274009994 Walker B; other site 316274009995 D-loop; other site 316274009996 H-loop/switch region; other site 316274009997 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274009998 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 316274009999 putative ligand binding site [chemical binding]; other site 316274010000 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 316274010001 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 316274010002 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 316274010003 predicted active site [active] 316274010004 catalytic triad [active] 316274010005 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 316274010006 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 316274010007 active site 316274010008 multimer interface [polypeptide binding]; other site 316274010009 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274010010 Cobalt transport protein; Region: CbiQ; cl00463 316274010011 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 316274010012 C-terminal peptidase (prc); Region: prc; TIGR00225 316274010013 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 316274010014 Domain interface; other site 316274010015 Peptide binding site; other site 316274010016 Active site tetrad [active] 316274010017 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 316274010018 peptidase T-like protein; Region: PepT-like; TIGR01883 316274010019 metal binding site [ion binding]; metal-binding site 316274010020 putative dimer interface [polypeptide binding]; other site 316274010021 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 316274010022 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274010023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 316274010024 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 316274010025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274010026 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 316274010027 EamA-like transporter family; Region: EamA; cl01037 316274010028 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274010029 EamA-like transporter family; Region: EamA; cl01037 316274010030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274010031 S-adenosylmethionine binding site [chemical binding]; other site 316274010032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274010033 S-adenosylmethionine binding site [chemical binding]; other site 316274010034 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274010035 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316274010036 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 316274010037 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010038 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274010039 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 316274010040 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 316274010041 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316274010042 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 316274010043 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 316274010044 oligomer interface [polypeptide binding]; other site 316274010045 active site residues [active] 316274010046 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 316274010047 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 316274010048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274010049 Walker A motif; other site 316274010050 ATP binding site [chemical binding]; other site 316274010051 Walker B motif; other site 316274010052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274010053 short chain dehydrogenase; Provisional; Region: PRK06197 316274010054 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 316274010055 putative NAD(P) binding site [chemical binding]; other site 316274010056 active site 316274010057 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274010058 Protein of unknown function (DUF554); Region: DUF554; cl00784 316274010059 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274010060 DNA binding residues [nucleotide binding] 316274010061 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 316274010062 drug binding residues [chemical binding]; other site 316274010063 dimer interface [polypeptide binding]; other site 316274010064 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 316274010065 histidyl-tRNA synthetase; Region: hisS; TIGR00442 316274010066 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 316274010067 dimer interface [polypeptide binding]; other site 316274010068 motif 1; other site 316274010069 motif 2; other site 316274010070 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274010071 active site 316274010072 motif 3; other site 316274010073 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 316274010074 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 316274010075 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 316274010076 dimer interface [polypeptide binding]; other site 316274010077 motif 1; other site 316274010078 active site 316274010079 motif 2; other site 316274010080 motif 3; other site 316274010081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274010082 dimerization interface [polypeptide binding]; other site 316274010083 putative DNA binding site [nucleotide binding]; other site 316274010084 putative Zn2+ binding site [ion binding]; other site 316274010085 Beta-lactamase; Region: Beta-lactamase; cl01009 316274010086 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010087 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010088 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010089 YGGT family; Region: YGGT; cl00508 316274010090 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 316274010091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274010092 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274010093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274010094 S-adenosylmethionine binding site [chemical binding]; other site 316274010095 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274010096 phosphoglycerate mutase; Provisional; Region: PTZ00122 316274010097 catalytic core [active] 316274010098 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 316274010099 cofactor binding site; other site 316274010100 metal binding site [ion binding]; metal-binding site 316274010101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274010102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274010103 binding surface 316274010104 TPR motif; other site 316274010105 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 316274010106 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274010107 Phosphotransferase enzyme family; Region: APH; pfam01636 316274010108 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274010109 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 316274010110 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 316274010111 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 316274010112 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 316274010113 generic binding surface II; other site 316274010114 generic binding surface I; other site 316274010115 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 316274010116 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274010117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274010118 DNA binding residues [nucleotide binding] 316274010119 CsbD-like; Region: CsbD; cl01272 316274010120 CsbD-like; Region: CsbD; cl01272 316274010121 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274010122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274010123 TIGR03663 family protein; Region: TIGR03663 316274010124 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274010125 NHL repeat; Region: NHL; pfam01436 316274010126 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274010127 TIGR03663 family protein; Region: TIGR03663 316274010128 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 316274010129 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274010130 NAD binding site [chemical binding]; other site 316274010131 catalytic residues [active] 316274010132 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274010133 hypothetical protein; Provisional; Region: PRK04262 316274010134 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 316274010135 dimer interface [polypeptide binding]; other site 316274010136 active site 316274010137 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 316274010138 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 316274010139 active site 316274010140 DUF35 OB-fold domain; Region: DUF35; pfam01796 316274010141 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 316274010142 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 316274010143 putative trimer interface [polypeptide binding]; other site 316274010144 putative CoA binding site [chemical binding]; other site 316274010145 Bacterial sugar transferase; Region: Bac_transf; cl00939 316274010146 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 316274010147 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274010148 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274010149 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 316274010150 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 316274010151 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 316274010152 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274010153 dimerization interface [polypeptide binding]; other site 316274010154 Metal binding site [ion binding]; metal-binding site 316274010155 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 316274010156 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 316274010157 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 316274010158 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 316274010159 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 316274010160 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 316274010161 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 316274010162 putative nucleic acid binding region [nucleotide binding]; other site 316274010163 G-X-X-G motif; other site 316274010164 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 316274010165 RNA binding site [nucleotide binding]; other site 316274010166 domain interface; other site 316274010167 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 316274010168 16S/18S rRNA binding site [nucleotide binding]; other site 316274010169 S13e-L30e interaction site [polypeptide binding]; other site 316274010170 25S rRNA binding site [nucleotide binding]; other site 316274010171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274010172 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 316274010173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010174 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 316274010175 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274010176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274010177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274010178 catalytic residue [active] 316274010179 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 316274010180 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 316274010181 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 316274010182 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 316274010183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274010184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274010185 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 316274010186 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 316274010187 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274010188 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 316274010189 putative NAD(P) binding site [chemical binding]; other site 316274010190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274010191 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 316274010192 cobalamin binding residues [chemical binding]; other site 316274010193 putative BtuC binding residues; other site 316274010194 dimer interface [polypeptide binding]; other site 316274010195 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274010196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274010198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010199 NAD(P) binding site [chemical binding]; other site 316274010200 active site 316274010201 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274010202 Ligand binding site [chemical binding]; other site 316274010203 Putative Catalytic site [active] 316274010204 DXD motif; other site 316274010205 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 316274010206 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 316274010207 methionine aminotransferase; Validated; Region: PRK09082 316274010208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274010209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274010210 homodimer interface [polypeptide binding]; other site 316274010211 catalytic residue [active] 316274010212 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274010213 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 316274010214 NADP binding site [chemical binding]; other site 316274010215 dimer interface [polypeptide binding]; other site 316274010216 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 316274010217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010218 GAF domain; Region: GAF; cl00853 316274010219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274010220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274010221 dimer interface [polypeptide binding]; other site 316274010222 phosphorylation site [posttranslational modification] 316274010223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010224 ATP binding site [chemical binding]; other site 316274010225 Mg2+ binding site [ion binding]; other site 316274010226 G-X-G motif; other site 316274010227 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010229 active site 316274010230 phosphorylation site [posttranslational modification] 316274010231 intermolecular recognition site; other site 316274010232 dimerization interface [polypeptide binding]; other site 316274010233 Chromate transporter; Region: Chromate_transp; pfam02417 316274010234 Chromate transporter; Region: Chromate_transp; pfam02417 316274010235 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274010236 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274010237 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 316274010238 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 316274010239 active site residue [active] 316274010240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010241 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 316274010242 NAD(P) binding site [chemical binding]; other site 316274010243 active site 316274010244 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 316274010245 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274010246 Predicted methyltransferases [General function prediction only]; Region: COG0313 316274010247 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 316274010248 large T antigen; Provisional; Region: PHA02624 316274010249 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 316274010250 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 316274010251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274010252 Walker A motif; other site 316274010253 ATP binding site [chemical binding]; other site 316274010254 Walker B motif; other site 316274010255 arginine finger; other site 316274010256 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 316274010257 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 316274010258 recombination protein RecR; Reviewed; Region: recR; PRK00076 316274010259 RecR protein; Region: RecR; pfam02132 316274010260 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 316274010261 putative active site [active] 316274010262 putative metal-binding site [ion binding]; other site 316274010263 tetramer interface [polypeptide binding]; other site 316274010264 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274010265 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274010266 metal ion-dependent adhesion site (MIDAS); other site 316274010267 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274010268 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274010269 metal ion-dependent adhesion site (MIDAS); other site 316274010270 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274010271 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 316274010272 ApbE family; Region: ApbE; cl00643 316274010273 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 316274010274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274010275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010276 active site 316274010277 phosphorylation site [posttranslational modification] 316274010278 intermolecular recognition site; other site 316274010279 dimerization interface [polypeptide binding]; other site 316274010280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274010281 DNA binding site [nucleotide binding] 316274010282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274010283 dimer interface [polypeptide binding]; other site 316274010284 phosphorylation site [posttranslational modification] 316274010285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010286 ATP binding site [chemical binding]; other site 316274010287 Mg2+ binding site [ion binding]; other site 316274010288 G-X-G motif; other site 316274010289 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 316274010290 DinB superfamily; Region: DinB_2; cl00986 316274010291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274010292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274010293 putative substrate translocation pore; other site 316274010294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010295 GAF domain; Region: GAF; cl00853 316274010296 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274010297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274010298 dimer interface [polypeptide binding]; other site 316274010299 phosphorylation site [posttranslational modification] 316274010300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010301 ATP binding site [chemical binding]; other site 316274010302 Mg2+ binding site [ion binding]; other site 316274010303 G-X-G motif; other site 316274010304 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274010305 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274010306 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274010307 metal ion-dependent adhesion site (MIDAS); other site 316274010308 TadE-like protein; Region: TadE; pfam07811 316274010309 TadE-like protein; Region: TadE; pfam07811 316274010310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010311 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274010312 active site 316274010313 ATP binding site [chemical binding]; other site 316274010314 substrate binding site [chemical binding]; other site 316274010315 activation loop (A-loop); other site 316274010316 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010317 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274010318 active site 316274010319 ATP binding site [chemical binding]; other site 316274010320 substrate binding site [chemical binding]; other site 316274010321 activation loop (A-loop); other site 316274010322 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 316274010323 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 316274010324 glutaminase active site [active] 316274010325 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316274010326 dimer interface [polypeptide binding]; other site 316274010327 active site 316274010328 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316274010329 dimer interface [polypeptide binding]; other site 316274010330 active site 316274010331 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 316274010332 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 316274010333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274010335 Walker B motif; other site 316274010336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274010337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274010338 sequence-specific DNA binding site [nucleotide binding]; other site 316274010339 salt bridge; other site 316274010340 Chorismate lyase; Region: Chor_lyase; cl01230 316274010341 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274010342 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010343 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010344 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010346 active site 316274010347 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010348 PKS_DH; Region: PKS_DH; smart00826 316274010349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010350 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 316274010351 Enoylreductase; Region: PKS_ER; smart00829 316274010352 NAD(P) binding site [chemical binding]; other site 316274010353 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274010354 putative NADP binding site [chemical binding]; other site 316274010355 active site 316274010356 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010357 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010358 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010359 active site 316274010360 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010361 PKS_DH; Region: PKS_DH; smart00826 316274010362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010363 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 316274010364 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 316274010365 Enoylreductase; Region: PKS_ER; smart00829 316274010366 NAD(P) binding site [chemical binding]; other site 316274010367 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274010368 putative NADP binding site [chemical binding]; other site 316274010369 active site 316274010370 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010371 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010372 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010373 active site 316274010374 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010375 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010376 putative NADP binding site [chemical binding]; other site 316274010377 active site 316274010378 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010380 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274010381 active site 316274010382 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274010383 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010384 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010385 putative NADP binding site [chemical binding]; other site 316274010386 active site 316274010387 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010388 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274010389 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010390 active site 316274010391 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274010392 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010393 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010394 putative NADP binding site [chemical binding]; other site 316274010395 active site 316274010396 peptide synthase; Validated; Region: PRK05691 316274010397 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010398 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010399 active site 316274010400 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010401 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010402 putative NADP binding site [chemical binding]; other site 316274010403 active site 316274010404 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010405 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010407 active site 316274010408 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010409 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010410 putative NADP binding site [chemical binding]; other site 316274010411 active site 316274010412 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010413 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010414 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010415 active site 316274010416 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010418 NAD(P) binding site [chemical binding]; other site 316274010419 active site 316274010420 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010421 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010422 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010423 active site 316274010424 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010425 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010426 putative NADP binding site [chemical binding]; other site 316274010427 active site 316274010428 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010429 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010431 active site 316274010432 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010433 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010434 putative NADP binding site [chemical binding]; other site 316274010435 active site 316274010436 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010437 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010438 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274010439 active site 316274010440 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274010441 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010443 NAD(P) binding site [chemical binding]; other site 316274010444 active site 316274010445 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010446 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010448 active site 316274010449 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010450 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010451 putative NADP binding site [chemical binding]; other site 316274010452 active site 316274010453 peptide synthase; Provisional; Region: PRK12467 316274010454 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010455 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010456 active site 316274010457 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010458 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010459 putative NADP binding site [chemical binding]; other site 316274010460 active site 316274010461 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010462 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010463 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010464 active site 316274010465 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010466 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010467 putative NADP binding site [chemical binding]; other site 316274010468 active site 316274010469 peptide synthase; Provisional; Region: PRK12316 316274010470 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010471 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010472 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010473 active site 316274010474 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010475 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010476 putative NADP binding site [chemical binding]; other site 316274010477 active site 316274010478 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010479 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274010480 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274010481 active site 316274010482 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316274010483 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274010484 putative NADP binding site [chemical binding]; other site 316274010485 active site 316274010486 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010487 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 316274010488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010489 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274010490 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274010492 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274010493 active site 316274010494 FkbH-like domain; Region: FkbH; TIGR01686 316274010495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274010496 Condensation domain; Region: Condensation; cl09290 316274010497 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274010498 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010499 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010500 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010501 peptide synthase; Provisional; Region: PRK12316 316274010502 peptide synthase; Validated; Region: PRK05691 316274010503 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010504 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010505 Condensation domain; Region: Condensation; cl09290 316274010506 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010507 Condensation domain; Region: Condensation; cl09290 316274010508 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010509 Condensation domain; Region: Condensation; cl09290 316274010510 Condensation domain; Region: Condensation; cl09290 316274010511 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010512 Condensation domain; Region: Condensation; cl09290 316274010513 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274010514 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010515 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010516 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274010517 Condensation domain; Region: Condensation; cl09290 316274010518 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010519 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274010520 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316274010521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274010522 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274010523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274010524 Thioesterase domain; Region: Thioesterase; pfam00975 316274010525 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274010526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274010527 Walker A/P-loop; other site 316274010528 ATP binding site [chemical binding]; other site 316274010529 Q-loop/lid; other site 316274010530 ABC transporter signature motif; other site 316274010531 Walker B; other site 316274010532 D-loop; other site 316274010533 H-loop/switch region; other site 316274010534 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274010535 NeuB family; Region: NeuB; cl00496 316274010536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 316274010537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274010538 S-adenosylmethionine binding site [chemical binding]; other site 316274010539 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274010540 classical (c) SDRs; Region: SDR_c; cd05233 316274010541 NAD(P) binding site [chemical binding]; other site 316274010542 active site 316274010543 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316274010544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274010545 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 316274010546 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 316274010547 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 316274010548 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 316274010549 B12 binding site [chemical binding]; other site 316274010550 cobalt ligand [ion binding]; other site 316274010551 LAO/AO transport system ATPase; Region: lao; TIGR00750 316274010552 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 316274010553 Walker A; other site 316274010554 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274010555 Ligand binding site [chemical binding]; other site 316274010556 Ligand binding site [chemical binding]; other site 316274010557 Ligand binding site [chemical binding]; other site 316274010558 Putative Catalytic site [active] 316274010559 DXD motif; other site 316274010560 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274010561 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 316274010562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274010563 Walker A motif; other site 316274010564 ATP binding site [chemical binding]; other site 316274010565 Walker B motif; other site 316274010566 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274010567 peptide chain release factor 2; Region: prfB; TIGR00020 316274010568 RF-1 domain; Region: RF-1; cl02875 316274010569 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 316274010570 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316274010571 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316274010572 Clostripain family; Region: Peptidase_C11; cl04055 316274010573 Uncharacterized conserved protein [Function unknown]; Region: COG1572 316274010574 CARDB; Region: CARDB; pfam07705 316274010575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274010576 binding surface 316274010577 TPR motif; other site 316274010578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274010579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274010580 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274010581 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 316274010582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274010583 dimer interface [polypeptide binding]; other site 316274010584 conserved gate region; other site 316274010585 putative PBP binding loops; other site 316274010586 ABC-ATPase subunit interface; other site 316274010587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274010588 dimer interface [polypeptide binding]; other site 316274010589 conserved gate region; other site 316274010590 putative PBP binding loops; other site 316274010591 ABC-ATPase subunit interface; other site 316274010592 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 316274010593 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 316274010594 Walker A/P-loop; other site 316274010595 ATP binding site [chemical binding]; other site 316274010596 Q-loop/lid; other site 316274010597 ABC transporter signature motif; other site 316274010598 Walker B; other site 316274010599 D-loop; other site 316274010600 H-loop/switch region; other site 316274010601 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274010602 PhoU domain; Region: PhoU; pfam01895 316274010603 PhoU domain; Region: PhoU; pfam01895 316274010604 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 316274010605 active site 316274010606 catalytic residues [active] 316274010607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274010608 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 316274010609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010610 putative ADP-binding pocket [chemical binding]; other site 316274010611 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274010612 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274010613 active site 316274010614 dimer interface [polypeptide binding]; other site 316274010615 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 316274010616 Ligand Binding Site [chemical binding]; other site 316274010617 Molecular Tunnel; other site 316274010618 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 316274010619 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274010620 Chain length determinant protein; Region: Wzz; cl01623 316274010621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010622 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 316274010623 putative ADP-binding pocket [chemical binding]; other site 316274010624 YCII-related domain; Region: YCII; cl00999 316274010625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274010626 active site 316274010627 metal binding site [ion binding]; metal-binding site 316274010628 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 316274010629 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 316274010630 hypothetical protein; Provisional; Region: PRK08609 316274010631 active site 316274010632 primer binding site [nucleotide binding]; other site 316274010633 NTP binding site [chemical binding]; other site 316274010634 metal binding triad [ion binding]; metal-binding site 316274010635 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 316274010636 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 316274010637 HIT family signature motif; other site 316274010638 catalytic residue [active] 316274010639 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 316274010640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274010641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274010642 catalytic residue [active] 316274010643 MOFRL family; Region: MOFRL; cl01013 316274010644 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274010645 peptide binding site [polypeptide binding]; other site 316274010646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274010647 dimer interface [polypeptide binding]; other site 316274010648 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 316274010649 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 316274010650 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 316274010651 active site 316274010652 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274010653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274010654 binding surface 316274010655 TPR motif; other site 316274010656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274010657 binding surface 316274010658 TPR motif; other site 316274010659 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 316274010660 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274010661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274010662 Protein of unknown function DUF262; Region: DUF262; cl14890 316274010663 Protein of unknown function DUF262; Region: DUF262; cl14890 316274010664 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 316274010665 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274010666 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 316274010667 Bacterial SH3 domain; Region: SH3_3; cl02551 316274010668 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274010669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274010670 ABC-ATPase subunit interface; other site 316274010671 dimer interface [polypeptide binding]; other site 316274010672 putative PBP binding regions; other site 316274010673 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 316274010674 ABC-ATPase subunit interface; other site 316274010675 dimer interface [polypeptide binding]; other site 316274010676 putative PBP binding regions; other site 316274010677 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274010678 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 316274010679 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 316274010680 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274010681 intersubunit interface [polypeptide binding]; other site 316274010682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274010683 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 316274010684 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 316274010685 FeoA domain; Region: FeoA; cl00838 316274010686 glutamine synthetase, type I; Region: GlnA; TIGR00653 316274010687 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316274010688 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316274010689 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274010690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274010691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274010692 dimer interface [polypeptide binding]; other site 316274010693 conserved gate region; other site 316274010694 putative PBP binding loops; other site 316274010695 ABC-ATPase subunit interface; other site 316274010696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274010697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274010698 dimer interface [polypeptide binding]; other site 316274010699 conserved gate region; other site 316274010700 putative PBP binding loops; other site 316274010701 ABC-ATPase subunit interface; other site 316274010702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274010703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010704 active site 316274010705 phosphorylation site [posttranslational modification] 316274010706 intermolecular recognition site; other site 316274010707 dimerization interface [polypeptide binding]; other site 316274010708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274010709 DNA binding site [nucleotide binding] 316274010710 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 316274010711 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 316274010712 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274010713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274010714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010715 active site 316274010716 phosphorylation site [posttranslational modification] 316274010717 intermolecular recognition site; other site 316274010718 dimerization interface [polypeptide binding]; other site 316274010719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274010720 DNA binding residues [nucleotide binding] 316274010721 dimerization interface [polypeptide binding]; other site 316274010722 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 316274010723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274010724 active site 316274010725 ATP binding site [chemical binding]; other site 316274010726 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010727 substrate binding site [chemical binding]; other site 316274010728 activation loop (A-loop); other site 316274010729 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 316274010730 Trp docking motif; other site 316274010731 active site 316274010732 The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874 316274010733 homodimer interface [polypeptide binding]; other site 316274010734 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274010735 Protein phosphatase 2C; Region: PP2C; pfam00481 316274010736 Active site [active] 316274010737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274010738 metal ion-dependent adhesion site (MIDAS); other site 316274010739 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 316274010740 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274010741 phosphopeptide binding site; other site 316274010742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274010743 cytoskeletal protein RodZ; Provisional; Region: PRK10856 316274010744 Protein of unknown function (DUF520); Region: DUF520; cl00723 316274010745 putative oxidoreductase; Provisional; Region: PRK11579 316274010746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 316274010748 tRNAHis guanylyltransferase; Region: Thg1; cl01644 316274010749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274010750 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274010751 Leucine-rich repeats; other site 316274010752 Substrate binding site [chemical binding]; other site 316274010753 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 316274010754 Leucine-rich repeats; other site 316274010755 Substrate binding site [chemical binding]; other site 316274010756 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 316274010757 active site 316274010758 nucleophile elbow; other site 316274010759 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 316274010760 catalytic center binding site [active] 316274010761 ATP binding site [chemical binding]; other site 316274010762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274010763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274010764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274010765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010766 active site 316274010767 phosphorylation site [posttranslational modification] 316274010768 intermolecular recognition site; other site 316274010769 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010770 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274010771 PhoD-like phosphatase; Region: PhoD; pfam09423 316274010772 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 316274010773 putative active site [active] 316274010774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274010775 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274010776 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274010777 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274010778 VanW like protein; Region: VanW; pfam04294 316274010779 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274010780 Domain of unknown function DUF20; Region: UPF0118; cl00465 316274010781 GAF domain; Region: GAF; cl00853 316274010782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274010783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274010784 dimer interface [polypeptide binding]; other site 316274010785 phosphorylation site [posttranslational modification] 316274010786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010787 ATP binding site [chemical binding]; other site 316274010788 Mg2+ binding site [ion binding]; other site 316274010789 G-X-G motif; other site 316274010790 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274010791 putative active site [active] 316274010792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274010793 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274010794 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274010795 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 316274010796 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to...; Region: CBM20_alpha_amylase; cd05808 316274010797 starch-binding site 2 [chemical binding]; other site 316274010798 starch-binding site 1 [chemical binding]; other site 316274010799 ATP synthase A chain; Region: ATP-synt_A; cl00413 316274010800 ATP synthase A chain; Region: ATP-synt_A; cl00413 316274010801 ATP synthase subunit C; Region: ATP-synt_C; cl00466 316274010802 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 316274010803 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 316274010804 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 316274010805 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 316274010806 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316274010807 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 316274010808 beta subunit interaction interface [polypeptide binding]; other site 316274010809 Walker A motif; other site 316274010810 ATP binding site [chemical binding]; other site 316274010811 Walker B motif; other site 316274010812 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316274010813 ATP synthase; Region: ATP-synt; cl00365 316274010814 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 316274010815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316274010816 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 316274010817 alpha subunit interaction interface [polypeptide binding]; other site 316274010818 Walker A motif; other site 316274010819 ATP binding site [chemical binding]; other site 316274010820 Walker B motif; other site 316274010821 inhibitor binding site; inhibition site 316274010822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316274010823 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 316274010824 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 316274010825 rod shape-determining protein MreB; Provisional; Region: PRK13930 316274010826 Cell division protein FtsA; Region: FtsA; cl11496 316274010827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274010828 Zn2+ binding site [ion binding]; other site 316274010829 Mg2+ binding site [ion binding]; other site 316274010830 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 316274010831 active site 316274010832 substrate-binding site [chemical binding]; other site 316274010833 metal-binding site [ion binding] 316274010834 ATP binding site [chemical binding]; other site 316274010835 CHAT domain; Region: CHAT; cl02083 316274010836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274010837 Walker A motif; other site 316274010838 ATP binding site [chemical binding]; other site 316274010839 Walker B motif; other site 316274010840 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 316274010841 MutS domain I; Region: MutS_I; pfam01624 316274010842 MutS domain II; Region: MutS_II; pfam05188 316274010843 MutS family domain IV; Region: MutS_IV; pfam05190 316274010844 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 316274010845 Walker A/P-loop; other site 316274010846 ATP binding site [chemical binding]; other site 316274010847 Q-loop/lid; other site 316274010848 ABC transporter signature motif; other site 316274010849 Walker B; other site 316274010850 D-loop; other site 316274010851 H-loop/switch region; other site 316274010852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274010853 Prephenate dehydrogenase; Region: PDH; pfam02153 316274010854 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 316274010855 Tetramer interface [polypeptide binding]; other site 316274010856 Active site [active] 316274010857 FMN-binding site [chemical binding]; other site 316274010858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274010859 TPR motif; other site 316274010860 binding surface 316274010861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274010863 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 316274010864 dimer interface [polypeptide binding]; other site 316274010865 ligand binding site [chemical binding]; other site 316274010866 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 316274010867 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274010868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 316274010869 protein binding site [polypeptide binding]; other site 316274010870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274010871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274010872 DNA binding residues [nucleotide binding] 316274010873 dimerization interface [polypeptide binding]; other site 316274010874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274010875 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274010876 anti sigma factor interaction site; other site 316274010877 regulatory phosphorylation site [posttranslational modification]; other site 316274010878 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274010879 competence damage-inducible protein A; Provisional; Region: PRK00549 316274010880 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 316274010881 putative MPT binding site; other site 316274010882 dihydroorotase; Validated; Region: pyrC; PRK09357 316274010883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 316274010884 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 316274010885 active site 316274010886 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 316274010887 6-phosphofructokinase; Provisional; Region: PRK03202 316274010888 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 316274010889 active site 316274010890 ADP/pyrophosphate binding site [chemical binding]; other site 316274010891 dimerization interface [polypeptide binding]; other site 316274010892 allosteric effector site; other site 316274010893 fructose-1,6-bisphosphate binding site; other site 316274010894 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 316274010895 primosome assembly protein PriA; Validated; Region: PRK05580 316274010896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274010897 ATP binding site [chemical binding]; other site 316274010898 putative Mg++ binding site [ion binding]; other site 316274010899 aconitate hydratase; Validated; Region: PRK09277 316274010900 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 316274010901 substrate binding site [chemical binding]; other site 316274010902 ligand binding site [chemical binding]; other site 316274010903 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 316274010904 substrate binding site [chemical binding]; other site 316274010905 cyclase homology domain; Region: CHD; cd07302 316274010906 nucleotidyl binding site; other site 316274010907 metal binding site [ion binding]; metal-binding site 316274010908 dimer interface [polypeptide binding]; other site 316274010909 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 316274010910 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274010911 dimer interface [polypeptide binding]; other site 316274010912 ssDNA binding site [nucleotide binding]; other site 316274010913 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274010914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274010915 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010917 active site 316274010918 phosphorylation site [posttranslational modification] 316274010919 intermolecular recognition site; other site 316274010920 dimerization interface [polypeptide binding]; other site 316274010921 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010922 GAF domain; Region: GAF; cl00853 316274010923 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010924 GAF domain; Region: GAF; cl00853 316274010925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010926 GAF domain; Region: GAF; cl00853 316274010927 GAF domain; Region: GAF; cl00853 316274010928 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010929 GAF domain; Region: GAF; cl00853 316274010930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010931 GAF domain; Region: GAF; cl00853 316274010932 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010933 GAF domain; Region: GAF; cl00853 316274010934 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010935 GAF domain; Region: GAF; cl00853 316274010936 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010937 GAF domain; Region: GAF; cl00853 316274010938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010939 GAF domain; Region: GAF; cl00853 316274010940 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010941 GAF domain; Region: GAF; cl00853 316274010942 GAF domain; Region: GAF; cl00853 316274010943 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010944 GAF domain; Region: GAF; cl00853 316274010945 GAF domain; Region: GAF; cl00853 316274010946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274010947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274010948 dimer interface [polypeptide binding]; other site 316274010949 phosphorylation site [posttranslational modification] 316274010950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010951 ATP binding site [chemical binding]; other site 316274010952 Mg2+ binding site [ion binding]; other site 316274010953 G-X-G motif; other site 316274010954 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274010956 active site 316274010957 phosphorylation site [posttranslational modification] 316274010958 intermolecular recognition site; other site 316274010959 dimerization interface [polypeptide binding]; other site 316274010960 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 316274010961 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274010962 putative trimer interface [polypeptide binding]; other site 316274010963 putative CoA binding site [chemical binding]; other site 316274010964 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316274010965 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 316274010966 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 316274010967 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 316274010968 Cytochrome P450; Region: p450; cl12078 316274010969 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316274010970 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316274010971 active site 316274010972 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 316274010973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274010974 FeS/SAM binding site; other site 316274010975 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 316274010976 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316274010977 Cupin domain; Region: Cupin_2; cl09118 316274010978 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 316274010979 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 316274010980 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316274010981 active site 316274010982 HIGH motif; other site 316274010983 KMSK motif region; other site 316274010984 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316274010985 tRNA binding surface [nucleotide binding]; other site 316274010986 anticodon binding site; other site 316274010987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274010988 S-adenosylmethionine binding site [chemical binding]; other site 316274010989 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 316274010990 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316274010991 active site 316274010992 HIGH motif; other site 316274010993 KMSK motif region; other site 316274010994 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316274010995 tRNA binding surface [nucleotide binding]; other site 316274010996 anticodon binding site; other site 316274010997 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 316274010998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274010999 ornithine carbamoyltransferase; Provisional; Region: PRK00779 316274011000 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316274011001 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316274011002 argininosuccinate lyase; Provisional; Region: PRK00855 316274011003 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 316274011004 active sites [active] 316274011005 tetramer interface [polypeptide binding]; other site 316274011006 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 316274011007 heterotetramer interface [polypeptide binding]; other site 316274011008 active site pocket [active] 316274011009 cleavage site 316274011010 argininosuccinate synthase; Provisional; Region: PLN00200 316274011011 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 316274011012 ANP binding site [chemical binding]; other site 316274011013 Substrate Binding Site II [chemical binding]; other site 316274011014 Substrate Binding Site I [chemical binding]; other site 316274011015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274011016 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274011017 nudix motif; other site 316274011018 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 316274011019 nucleotide binding site [chemical binding]; other site 316274011020 N-acetyl-L-glutamate binding site [chemical binding]; other site 316274011021 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316274011022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011023 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 316274011024 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 316274011025 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_2; cd06102 316274011026 dimer interface [polypeptide binding]; other site 316274011027 active site 316274011028 coenzyme A binding site [chemical binding]; other site 316274011029 citrylCoA binding site [chemical binding]; other site 316274011030 Citrate synthase; Region: Citrate_synt; pfam00285 316274011031 oxalacetate/citrate binding site [chemical binding]; other site 316274011032 catalytic triad [active] 316274011033 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 316274011034 dimer interface [polypeptide binding]; other site 316274011035 Citrate synthase; Region: Citrate_synt; pfam00285 316274011036 active site 316274011037 citrylCoA binding site [chemical binding]; other site 316274011038 oxalacetate/citrate binding site [chemical binding]; other site 316274011039 coenzyme A binding site [chemical binding]; other site 316274011040 catalytic triad [active] 316274011041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274011042 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274011043 substrate binding pocket [chemical binding]; other site 316274011044 substrate-Mg2+ binding site; other site 316274011045 aspartate-rich region 1; other site 316274011046 aspartate-rich region 2; other site 316274011047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274011048 EamA-like transporter family; Region: EamA; cl01037 316274011049 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274011050 EamA-like transporter family; Region: EamA; cl01037 316274011051 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 316274011052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274011053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274011054 motif II; other site 316274011055 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316274011056 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274011057 dimerization interface [polypeptide binding]; other site 316274011058 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011059 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274011060 putative ligand binding site [chemical binding]; other site 316274011061 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 316274011062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274011063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011064 active site 316274011065 phosphorylation site [posttranslational modification] 316274011066 intermolecular recognition site; other site 316274011067 dimerization interface [polypeptide binding]; other site 316274011068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274011069 DNA binding site [nucleotide binding] 316274011070 High-affinity nickel-transport protein; Region: NicO; cl00964 316274011071 Low molecular weight phosphatase family; Region: LMWPc; cl00105 316274011072 Active site [active] 316274011073 Protein of unknown function (DUF524); Region: DUF524; pfam04411 316274011074 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 316274011075 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 316274011076 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 316274011077 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316274011078 P loop; other site 316274011079 GTP binding site [chemical binding]; other site 316274011080 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 316274011081 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 316274011082 substrate binding site [chemical binding]; other site 316274011083 metal binding site [ion binding]; metal-binding site 316274011084 Oligomer interface [polypeptide binding]; other site 316274011085 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274011086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 316274011087 binding surface 316274011088 TPR motif; other site 316274011089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274011090 binding surface 316274011091 TPR motif; other site 316274011092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274011093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274011094 ligand binding site [chemical binding]; other site 316274011095 flexible hinge region; other site 316274011096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274011097 translocation protein TolB; Provisional; Region: tolB; PRK00178 316274011098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274011099 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274011100 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274011101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274011102 DinB superfamily; Region: DinB_2; cl00986 316274011103 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 316274011104 SpoVR like protein; Region: SpoVR; pfam04293 316274011105 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 316274011106 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 316274011107 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274011108 Protein of unknown function (DUF444); Region: DUF444; pfam04285 316274011109 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 316274011110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274011111 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 316274011112 Cytochrome P450; Region: p450; cl12078 316274011113 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 316274011114 active site 316274011115 Zn binding site [ion binding]; other site 316274011116 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316274011117 NeuB family; Region: NeuB; cl00496 316274011118 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 316274011119 homotrimer interaction site [polypeptide binding]; other site 316274011120 active site 316274011121 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 316274011122 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 316274011123 putative substrate binding site [chemical binding]; other site 316274011124 putative ATP binding site [chemical binding]; other site 316274011125 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 316274011126 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316274011127 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316274011128 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 316274011129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274011130 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274011131 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274011132 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274011133 metal ion-dependent adhesion site (MIDAS); other site 316274011134 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274011135 CHAT domain; Region: CHAT; cl02083 316274011136 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 316274011137 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011138 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011139 RecX family; Region: RecX; cl00936 316274011140 recombinase A; Provisional; Region: recA; PRK09354 316274011141 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 316274011142 hexamer interface [polypeptide binding]; other site 316274011143 Walker A motif; other site 316274011144 ATP binding site [chemical binding]; other site 316274011145 Walker B motif; other site 316274011146 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 316274011147 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 316274011148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011149 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 316274011150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274011151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274011152 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274011153 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274011154 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 316274011155 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 316274011156 active site 316274011157 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 316274011158 IHF - DNA interface [nucleotide binding]; other site 316274011159 IHF dimer interface [polypeptide binding]; other site 316274011160 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316274011161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011162 active site 316274011163 phosphorylation site [posttranslational modification] 316274011164 intermolecular recognition site; other site 316274011165 dimerization interface [polypeptide binding]; other site 316274011166 ANTAR domain; Region: ANTAR; pfam03861 316274011167 malate dehydrogenase; Reviewed; Region: PRK06223 316274011168 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 316274011169 NAD(P) binding site [chemical binding]; other site 316274011170 dimer interface [polypeptide binding]; other site 316274011171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274011172 substrate binding site [chemical binding]; other site 316274011173 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 316274011174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274011175 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274011176 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 316274011177 pyruvate carboxylase subunit B; Validated; Region: PRK09282 316274011178 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 316274011179 carboxyltransferase (CT) interaction site; other site 316274011180 biotinylation site [posttranslational modification]; other site 316274011181 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274011182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274011183 metal ion-dependent adhesion site (MIDAS); other site 316274011184 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274011185 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274011186 metal ion-dependent adhesion site (MIDAS); other site 316274011187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274011188 substrate binding site [chemical binding]; other site 316274011189 activation loop (A-loop); other site 316274011190 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274011191 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274011192 Active site [active] 316274011193 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274011194 metal ion-dependent adhesion site (MIDAS); other site 316274011195 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 316274011196 Peptidase C26; Region: Peptidase_C26; pfam07722 316274011197 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 316274011198 catalytic triad [active] 316274011199 GAF domain; Region: GAF; cl00853 316274011200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011201 GAF domain; Region: GAF; cl00853 316274011202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274011203 metal binding site [ion binding]; metal-binding site 316274011204 active site 316274011205 I-site; other site 316274011206 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 316274011207 MgtE intracellular N domain; Region: MgtE_N; cl15244 316274011208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 316274011209 Divalent cation transporter; Region: MgtE; cl00786 316274011210 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274011211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274011212 active site 316274011213 catalytic tetrad [active] 316274011214 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 316274011215 active site 316274011216 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011218 active site 316274011219 phosphorylation site [posttranslational modification] 316274011220 intermolecular recognition site; other site 316274011221 dimerization interface [polypeptide binding]; other site 316274011222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274011223 binding surface 316274011224 TPR motif; other site 316274011225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274011226 binding surface 316274011227 TPR motif; other site 316274011228 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274011229 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 316274011230 active site 316274011231 multimer interface [polypeptide binding]; other site 316274011232 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 316274011233 GTPase CgtA; Reviewed; Region: obgE; PRK12297 316274011234 GTP1/OBG; Region: GTP1_OBG; pfam01018 316274011235 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 316274011236 G1 box; other site 316274011237 GTP/Mg2+ binding site [chemical binding]; other site 316274011238 Switch I region; other site 316274011239 G2 box; other site 316274011240 G3 box; other site 316274011241 Switch II region; other site 316274011242 G4 box; other site 316274011243 G5 box; other site 316274011244 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 316274011245 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 316274011246 Bacterial sugar transferase; Region: Bac_transf; cl00939 316274011247 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 316274011248 putative active site [active] 316274011249 catalytic site [active] 316274011250 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 316274011251 putative active site [active] 316274011252 catalytic site [active] 316274011253 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274011254 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274011255 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 316274011256 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 316274011257 Walker A/P-loop; other site 316274011258 ATP binding site [chemical binding]; other site 316274011259 Q-loop/lid; other site 316274011260 ABC transporter signature motif; other site 316274011261 Walker B; other site 316274011262 D-loop; other site 316274011263 H-loop/switch region; other site 316274011264 hypothetical protein; Provisional; Region: PRK08317 316274011265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274011266 S-adenosylmethionine binding site [chemical binding]; other site 316274011267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274011268 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011269 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011270 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316274011271 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011273 active site 316274011274 phosphorylation site [posttranslational modification] 316274011275 intermolecular recognition site; other site 316274011276 dimerization interface [polypeptide binding]; other site 316274011277 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 316274011278 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 316274011279 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 316274011280 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274011281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011282 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011283 active site 316274011284 phosphorylation site [posttranslational modification] 316274011285 intermolecular recognition site; other site 316274011286 dimerization interface [polypeptide binding]; other site 316274011287 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011288 GAF domain; Region: GAF; cl00853 316274011289 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274011290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274011291 putative active site [active] 316274011292 heme pocket [chemical binding]; other site 316274011293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274011294 dimer interface [polypeptide binding]; other site 316274011295 phosphorylation site [posttranslational modification] 316274011296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011297 ATP binding site [chemical binding]; other site 316274011298 Mg2+ binding site [ion binding]; other site 316274011299 G-X-G motif; other site 316274011300 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011302 active site 316274011303 phosphorylation site [posttranslational modification] 316274011304 intermolecular recognition site; other site 316274011305 dimerization interface [polypeptide binding]; other site 316274011306 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274011307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011308 active site 316274011309 phosphorylation site [posttranslational modification] 316274011310 intermolecular recognition site; other site 316274011311 dimerization interface [polypeptide binding]; other site 316274011312 enoyl-CoA hydratase; Provisional; Region: PRK06688 316274011313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 316274011314 substrate binding site [chemical binding]; other site 316274011315 oxyanion hole (OAH) forming residues; other site 316274011316 trimer interface [polypeptide binding]; other site 316274011317 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 316274011318 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 316274011319 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 316274011320 catalytic site [active] 316274011321 subunit interface [polypeptide binding]; other site 316274011322 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274011323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274011324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274011325 DNA binding residues [nucleotide binding] 316274011326 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274011327 amidase catalytic site [active] 316274011328 Zn binding residues [ion binding]; other site 316274011329 substrate binding site [chemical binding]; other site 316274011330 PA14 domain; Region: PA14; cl08459 316274011331 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274011332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 316274011333 putative substrate translocation pore; other site 316274011334 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 316274011335 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274011336 A functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site...; Region: Peptidase_M14-like_8; cd06905 316274011337 putative active site [active] 316274011338 Zn-binding site [ion binding]; other site 316274011339 Cytochrome c; Region: Cytochrom_C; cl11414 316274011340 Cytochrome c; Region: Cytochrom_C; cl11414 316274011341 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 316274011342 intrachain domain interface; other site 316274011343 heme bH binding site [chemical binding]; other site 316274011344 Qi binding site; other site 316274011345 heme bL binding site [chemical binding]; other site 316274011346 interchain domain interface [polypeptide binding]; other site 316274011347 Qo binding site; other site 316274011348 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 316274011349 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 316274011350 iron-sulfur cluster [ion binding]; other site 316274011351 [2Fe-2S] cluster binding site [ion binding]; other site 316274011352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274011353 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274011354 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011356 active site 316274011357 phosphorylation site [posttranslational modification] 316274011358 intermolecular recognition site; other site 316274011359 dimerization interface [polypeptide binding]; other site 316274011360 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011361 GAF domain; Region: GAF; cl00853 316274011362 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316274011363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274011364 putative active site [active] 316274011365 heme pocket [chemical binding]; other site 316274011366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274011367 dimer interface [polypeptide binding]; other site 316274011368 phosphorylation site [posttranslational modification] 316274011369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011370 ATP binding site [chemical binding]; other site 316274011371 Mg2+ binding site [ion binding]; other site 316274011372 G-X-G motif; other site 316274011373 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011375 active site 316274011376 phosphorylation site [posttranslational modification] 316274011377 intermolecular recognition site; other site 316274011378 dimerization interface [polypeptide binding]; other site 316274011379 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 316274011380 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 316274011381 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274011382 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 316274011383 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274011384 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 316274011385 active site 316274011386 HIGH motif; other site 316274011387 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274011388 active site 316274011389 KMSKS motif; other site 316274011390 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 316274011391 IPP transferase; Region: IPPT; cl00403 316274011392 RDD family; Region: RDD; cl00746 316274011393 Integral membrane protein DUF95; Region: DUF95; cl00572 316274011394 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 316274011395 putative peptidoglycan binding site; other site 316274011396 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274011397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274011398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274011399 S-adenosylmethionine binding site [chemical binding]; other site 316274011400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011401 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011402 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 316274011403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011404 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274011406 S-adenosylmethionine binding site [chemical binding]; other site 316274011407 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274011408 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 316274011409 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 316274011410 NAD binding site [chemical binding]; other site 316274011411 substrate binding site [chemical binding]; other site 316274011412 homodimer interface [polypeptide binding]; other site 316274011413 active site 316274011414 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 316274011415 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 316274011416 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274011418 S-adenosylmethionine binding site [chemical binding]; other site 316274011419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274011420 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 316274011421 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 316274011422 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 316274011423 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274011424 minor groove reading motif; other site 316274011425 helix-hairpin-helix signature motif; other site 316274011426 substrate binding pocket [chemical binding]; other site 316274011427 active site 316274011428 FES domain; Region: FES; smart00525 316274011429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274011430 Isochorismatase family; Region: Isochorismatase; pfam00857 316274011431 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 316274011432 catalytic triad [active] 316274011433 conserved cis-peptide bond; other site 316274011434 Predicted amidohydrolase [General function prediction only]; Region: COG0388 316274011435 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 316274011436 active site 316274011437 catalytic triad [active] 316274011438 dimer interface [polypeptide binding]; other site 316274011439 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 316274011440 NAD synthase; Region: NAD_synthase; pfam02540 316274011441 homodimer interface [polypeptide binding]; other site 316274011442 NAD binding pocket [chemical binding]; other site 316274011443 ATP binding pocket [chemical binding]; other site 316274011444 Mg binding site [ion binding]; other site 316274011445 active-site loop [active] 316274011446 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 316274011447 nudix motif; other site 316274011448 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274011449 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 316274011450 30S subunit binding site; other site 316274011451 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274011452 catalytic core [active] 316274011453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274011454 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274011455 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 316274011456 Protein of unknown function (DUF2393); Region: DUF2393; cl09840 316274011457 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 316274011458 Thymidylate synthase complementing protein; Region: Thy1; cl03630 316274011459 Thymidylate synthase complementing protein; Region: Thy1; cl03630 316274011460 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 316274011461 THUMP domain; Region: THUMP; cl12076 316274011462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274011463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 316274011464 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 316274011465 Sulfate transporter family; Region: Sulfate_transp; cl00967 316274011466 Permease family; Region: Xan_ur_permease; pfam00860 316274011467 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 316274011468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011469 active site 316274011470 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 316274011471 phosphorylation site [posttranslational modification] 316274011472 intermolecular recognition site; other site 316274011473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011474 active site 316274011475 phosphorylation site [posttranslational modification] 316274011476 intermolecular recognition site; other site 316274011477 dimerization interface [polypeptide binding]; other site 316274011478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274011479 metal binding site [ion binding]; metal-binding site 316274011480 active site 316274011481 I-site; other site 316274011482 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274011483 nudix motif; other site 316274011484 Protein kinase domain; Region: Pkinase; pfam00069 316274011485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274011486 active site 316274011487 ATP binding site [chemical binding]; other site 316274011488 substrate binding site [chemical binding]; other site 316274011489 activation loop (A-loop); other site 316274011490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274011491 binding surface 316274011492 TPR motif; other site 316274011493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274011494 binding surface 316274011495 TPR motif; other site 316274011496 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274011497 nudix motif; other site 316274011498 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274011499 Probable Catalytic site [active] 316274011500 metal binding site [ion binding]; metal-binding site 316274011501 mevalonate kinase; Region: mevalon_kin; TIGR00549 316274011502 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316274011503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011504 Coenzyme A binding pocket [chemical binding]; other site 316274011505 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316274011506 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316274011507 Protein export membrane protein; Region: SecD_SecF; cl14618 316274011508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274011509 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 316274011510 active site 316274011511 Protein kinase domain; Region: Pkinase; pfam00069 316274011512 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274011513 active site 316274011514 ATP binding site [chemical binding]; other site 316274011515 substrate binding site [chemical binding]; other site 316274011516 activation loop (A-loop); other site 316274011517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 316274011518 nudix motif; other site 316274011519 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 316274011520 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316274011521 inhibitor-cofactor binding pocket; inhibition site 316274011522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274011523 catalytic residue [active] 316274011524 3,8-divinyl protochlorophyllide a 8-vinyl reductase; Region: PLN02657 316274011525 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274011526 extended (e) SDRs; Region: SDR_e; cd08946 316274011527 NAD(P) binding site [chemical binding]; other site 316274011528 active site 316274011529 substrate binding site [chemical binding]; other site 316274011530 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274011532 metal-binding site [ion binding] 316274011533 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316274011534 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274011535 metal-binding site [ion binding] 316274011536 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274011537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274011538 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 316274011539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011541 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 316274011542 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 316274011543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274011544 S-adenosylmethionine binding site [chemical binding]; other site 316274011545 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 316274011546 Flavoprotein; Region: Flavoprotein; cl08021 316274011547 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274011548 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 316274011549 Divergent AAA domain; Region: AAA_4; pfam04326 316274011550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274011551 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along...; Region: GH31_glucosidase_KIAA1161; cd06592 316274011552 putative active site [active] 316274011553 putative catalytic site [active] 316274011554 putative alpha-glucosidase; Provisional; Region: PRK10658 316274011555 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 316274011556 maltodextrin glucosidase; Provisional; Region: PRK10785 316274011557 homodimer; other site 316274011558 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274011559 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274011560 Interdomain contacts; other site 316274011561 Cytokine receptor motif; other site 316274011562 Copper resistance protein CopC; Region: CopC; cl01012 316274011563 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 316274011564 maltodextrin glucosidase; Provisional; Region: PRK10785 316274011565 homodimer; other site 316274011566 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 316274011567 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 316274011568 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274011569 DNA binding site [nucleotide binding] 316274011570 active site 316274011571 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 316274011572 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274011573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274011574 TM-ABC transporter signature motif; other site 316274011575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274011576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274011577 Walker A/P-loop; other site 316274011578 ATP binding site [chemical binding]; other site 316274011579 Q-loop/lid; other site 316274011580 ABC transporter signature motif; other site 316274011581 Walker B; other site 316274011582 D-loop; other site 316274011583 H-loop/switch region; other site 316274011584 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274011585 putative ligand binding site [chemical binding]; other site 316274011586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274011587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011588 active site 316274011589 phosphorylation site [posttranslational modification] 316274011590 intermolecular recognition site; other site 316274011591 dimerization interface [polypeptide binding]; other site 316274011592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274011593 DNA binding residues [nucleotide binding] 316274011594 dimerization interface [polypeptide binding]; other site 316274011595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011596 active site 316274011597 phosphorylation site [posttranslational modification] 316274011598 intermolecular recognition site; other site 316274011599 seryl-tRNA synthetase; Provisional; Region: PRK05431 316274011600 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 316274011601 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 316274011602 dimer interface [polypeptide binding]; other site 316274011603 active site 316274011604 motif 1; other site 316274011605 motif 2; other site 316274011606 motif 3; other site 316274011607 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 316274011608 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 316274011609 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 316274011610 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 316274011611 active site 316274011612 NAD binding site [chemical binding]; other site 316274011613 metal binding site [ion binding]; metal-binding site 316274011614 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 316274011615 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 316274011616 Protein of unknown function DUF124; Region: DUF124; cl00884 316274011617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274011618 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316274011619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011620 active site 316274011621 phosphorylation site [posttranslational modification] 316274011622 intermolecular recognition site; other site 316274011623 dimerization interface [polypeptide binding]; other site 316274011624 ANTAR domain; Region: ANTAR; pfam03861 316274011625 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 316274011626 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 316274011627 quinone interaction residues [chemical binding]; other site 316274011628 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 316274011629 active site 316274011630 catalytic residues [active] 316274011631 FMN binding site [chemical binding]; other site 316274011632 substrate binding site [chemical binding]; other site 316274011633 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 316274011634 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 316274011635 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 316274011636 kelch-like protein; Provisional; Region: PHA03098 316274011637 Kelch motif; Region: Kelch_1; cl02701 316274011638 Kelch motif; Region: Kelch_1; cl02701 316274011639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274011640 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274011641 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 316274011642 active site 316274011643 metal binding site [ion binding]; metal-binding site 316274011644 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274011645 Predicted dehydrogenase [General function prediction only]; Region: COG5322 316274011646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011647 NAD(P) binding pocket [chemical binding]; other site 316274011648 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 316274011649 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 316274011650 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274011651 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cd00538 316274011652 PA/protease or protease-like domain interface [polypeptide binding]; other site 316274011653 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274011654 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 316274011655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274011656 nucleophilic elbow; other site 316274011657 catalytic triad; other site 316274011658 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274011659 dimer interface [polypeptide binding]; other site 316274011660 ssDNA binding site [nucleotide binding]; other site 316274011661 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274011662 DNA topoisomerase II large subunit; Provisional; Region: 39; PHA02569 316274011663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011664 ATP binding site [chemical binding]; other site 316274011665 Mg2+ binding site [ion binding]; other site 316274011666 G-X-G motif; other site 316274011667 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 316274011668 anchoring element; other site 316274011669 dimer interface [polypeptide binding]; other site 316274011670 ATP binding site [chemical binding]; other site 316274011671 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 316274011672 active site 316274011673 metal binding site [ion binding]; metal-binding site 316274011674 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 316274011675 thioester formation/cholesterol transfer; other site 316274011676 protein-splicing catalytic site; other site 316274011677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274011678 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 316274011679 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 316274011680 active site 316274011681 metal binding site [ion binding]; metal-binding site 316274011682 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 316274011683 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011684 GAF domain; Region: GAF; cl00853 316274011685 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274011686 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274011687 HSP90 family protein; Provisional; Region: PRK14083 316274011688 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 316274011689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274011690 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274011691 LamB/YcsF family; Region: LamB_YcsF; cl00664 316274011692 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274011693 Bacterial SH3 domain; Region: SH3_3; cl02551 316274011694 Bacterial SH3 domain; Region: SH3_3; cl02551 316274011695 Bacterial SH3 domain; Region: SH3_3; cl02551 316274011696 NlpC/P60 family; Region: NLPC_P60; cl11438 316274011697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011698 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274011699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274011700 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 316274011701 NAD binding site [chemical binding]; other site 316274011702 homotetramer interface [polypeptide binding]; other site 316274011703 homodimer interface [polypeptide binding]; other site 316274011704 active site 316274011705 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274011706 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 316274011707 dimer interface [polypeptide binding]; other site 316274011708 active site 316274011709 DNA topoisomerase I; Validated; Region: PRK06599 316274011710 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 316274011711 active site 316274011712 interdomain interaction site; other site 316274011713 putative metal-binding site [ion binding]; other site 316274011714 nucleotide binding site [chemical binding]; other site 316274011715 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 316274011716 domain I; other site 316274011717 DNA binding groove [nucleotide binding] 316274011718 phosphate binding site [ion binding]; other site 316274011719 domain II; other site 316274011720 domain III; other site 316274011721 nucleotide binding site [chemical binding]; other site 316274011722 catalytic site [active] 316274011723 domain IV; other site 316274011724 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 316274011725 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 316274011726 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 316274011727 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 316274011728 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 316274011729 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 316274011730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274011731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274011732 active site 316274011733 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 316274011734 active site 316274011735 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 316274011736 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 316274011737 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274011738 dimer interface [polypeptide binding]; other site 316274011739 active site 316274011740 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 316274011741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011742 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274011743 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274011744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 316274011745 substrate binding site [chemical binding]; other site 316274011746 oxyanion hole (OAH) forming residues; other site 316274011747 trimer interface [polypeptide binding]; other site 316274011748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274011749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274011750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 316274011751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 316274011752 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 316274011753 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 316274011754 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274011755 endonuclease III; Region: ENDO3c; smart00478 316274011756 minor groove reading motif; other site 316274011757 helix-hairpin-helix signature motif; other site 316274011758 substrate binding pocket [chemical binding]; other site 316274011759 active site 316274011760 FES domain; Region: FES; smart00525 316274011761 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274011762 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011764 active site 316274011765 phosphorylation site [posttranslational modification] 316274011766 intermolecular recognition site; other site 316274011767 dimerization interface [polypeptide binding]; other site 316274011768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274011769 dimer interface [polypeptide binding]; other site 316274011770 phosphorylation site [posttranslational modification] 316274011771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011772 ATP binding site [chemical binding]; other site 316274011773 Mg2+ binding site [ion binding]; other site 316274011774 G-X-G motif; other site 316274011775 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274011776 catalytic residues [active] 316274011777 adenylate kinase; Reviewed; Region: adk; PRK00279 316274011778 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316274011779 AMP-binding site [chemical binding]; other site 316274011780 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316274011781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274011782 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 316274011783 active site 316274011784 intersubunit interactions; other site 316274011785 catalytic residue [active] 316274011786 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316274011787 Domain of unknown function (DUF205); Region: DUF205; cl00410 316274011788 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 316274011789 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 316274011790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274011791 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 316274011792 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274011793 active site 316274011794 catalytic triad [active] 316274011795 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274011796 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274011797 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274011798 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274011799 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274011800 active site 316274011801 catalytic triad [active] 316274011802 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 316274011803 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 316274011804 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 316274011805 HIGH motif; other site 316274011806 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274011807 active site 316274011808 KMSKS motif; other site 316274011809 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 316274011810 tRNA binding surface [nucleotide binding]; other site 316274011811 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011812 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011813 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011814 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 316274011815 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 316274011816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011817 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274011818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 316274011819 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316274011820 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 316274011821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011822 ATP binding site [chemical binding]; other site 316274011823 Mg2+ binding site [ion binding]; other site 316274011824 G-X-G motif; other site 316274011825 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274011826 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 316274011827 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 316274011828 active site 316274011829 catalytic residues [active] 316274011830 metal binding site [ion binding]; metal-binding site 316274011831 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274011832 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 316274011833 NAD binding site [chemical binding]; other site 316274011834 putative substrate binding site 2 [chemical binding]; other site 316274011835 putative substrate binding site 1 [chemical binding]; other site 316274011836 active site 316274011837 O-Antigen ligase; Region: Wzy_C; cl04850 316274011838 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274011839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011840 NAD(P) binding site [chemical binding]; other site 316274011841 active site 316274011842 Predicted integral membrane protein [Function unknown]; Region: COG0392 316274011843 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 316274011844 DinB superfamily; Region: DinB_2; cl00986 316274011845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011846 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274011847 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274011848 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 316274011849 substrate binding site [chemical binding]; other site 316274011850 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 316274011851 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 316274011852 substrate binding site [chemical binding]; other site 316274011853 ligand binding site [chemical binding]; other site 316274011854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011855 Coenzyme A binding pocket [chemical binding]; other site 316274011856 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 316274011857 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 316274011858 homodimer interface [polypeptide binding]; other site 316274011859 substrate-cofactor binding pocket; other site 316274011860 catalytic residue [active] 316274011861 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 316274011862 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 316274011863 active site 316274011864 catalytic residues [active] 316274011865 metal binding site [ion binding]; metal-binding site 316274011866 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 316274011867 prephenate dehydratase; Provisional; Region: PRK11898 316274011868 Prephenate dehydratase; Region: PDT; pfam00800 316274011869 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 316274011870 putative L-Phe binding site [chemical binding]; other site 316274011871 2-isopropylmalate synthase; Validated; Region: PRK00915 316274011872 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 316274011873 active site 316274011874 catalytic residues [active] 316274011875 metal binding site [ion binding]; metal-binding site 316274011876 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 316274011877 ketol-acid reductoisomerase; Provisional; Region: PRK05479 316274011878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011879 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 316274011880 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 316274011881 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 316274011882 putative valine binding site [chemical binding]; other site 316274011883 dimer interface [polypeptide binding]; other site 316274011884 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 316274011885 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 316274011886 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 316274011887 PYR/PP interface [polypeptide binding]; other site 316274011888 dimer interface [polypeptide binding]; other site 316274011889 TPP binding site [chemical binding]; other site 316274011890 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 316274011891 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 316274011892 TPP-binding site [chemical binding]; other site 316274011893 dimer interface [polypeptide binding]; other site 316274011894 Dehydratase family; Region: ILVD_EDD; cl00340 316274011895 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 316274011896 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316274011897 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 316274011898 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316274011899 4Fe-4S binding domain; Region: Fer4_2; pfam12797 316274011900 Cysteine-rich domain; Region: CCG; pfam02754 316274011901 Cysteine-rich domain; Region: CCG; pfam02754 316274011902 Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Region: PurD; COG0151 316274011903 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316274011904 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274011905 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316274011906 Uncharacterized conserved protein [Function unknown]; Region: COG1543 316274011907 Uncharacterized conserved protein [Function unknown]; Region: COG1543 316274011908 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 316274011909 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274011910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274011911 active site 316274011912 catalytic tetrad [active] 316274011913 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 316274011914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274011915 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274011916 O-Antigen ligase; Region: Wzy_C; cl04850 316274011917 Domain of unknown function DUF11; Region: DUF11; cl03172 316274011918 YceG-like family; Region: YceG; pfam02618 316274011919 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 316274011920 dimerization interface [polypeptide binding]; other site 316274011921 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 316274011922 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 316274011923 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 316274011924 shikimate binding site; other site 316274011925 NAD(P) binding site [chemical binding]; other site 316274011926 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 316274011927 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 316274011928 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 316274011929 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 316274011930 homodimer interface [polypeptide binding]; other site 316274011931 NADP binding site [chemical binding]; other site 316274011932 substrate binding site [chemical binding]; other site 316274011933 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274011934 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274011935 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 316274011936 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 316274011937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274011938 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 316274011939 synthetase active site [active] 316274011940 NTP binding site [chemical binding]; other site 316274011941 metal binding site [ion binding]; metal-binding site 316274011942 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 316274011943 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 316274011944 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 316274011945 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 316274011946 active site 316274011947 dimer interface [polypeptide binding]; other site 316274011948 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 316274011949 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 316274011950 active site 316274011951 FMN binding site [chemical binding]; other site 316274011952 substrate binding site [chemical binding]; other site 316274011953 3Fe-4S cluster binding site [ion binding]; other site 316274011954 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 316274011955 domain_subunit interface; other site 316274011956 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274011957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274011958 putative active site [active] 316274011959 heme pocket [chemical binding]; other site 316274011960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274011961 dimer interface [polypeptide binding]; other site 316274011962 phosphorylation site [posttranslational modification] 316274011963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011964 ATP binding site [chemical binding]; other site 316274011965 Mg2+ binding site [ion binding]; other site 316274011966 G-X-G motif; other site 316274011967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274011968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274011969 active site 316274011970 phosphorylation site [posttranslational modification] 316274011971 intermolecular recognition site; other site 316274011972 dimerization interface [polypeptide binding]; other site 316274011973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274011974 DNA binding residues [nucleotide binding] 316274011975 dimerization interface [polypeptide binding]; other site 316274011976 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011977 GAF domain; Region: GAF; cl00853 316274011978 GAF domain; Region: GAF; cl00853 316274011979 Histidine kinase; Region: HisKA_3; pfam07730 316274011980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274011981 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 316274011982 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 316274011983 Substrate binding site [chemical binding]; other site 316274011984 Mg++ binding site [ion binding]; other site 316274011985 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 316274011986 active site 316274011987 substrate binding site [chemical binding]; other site 316274011988 CoA binding site [chemical binding]; other site 316274011989 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 316274011990 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274011991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011992 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011993 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 316274011994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274011995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011996 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011997 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316274011998 substrate binding pocket [chemical binding]; other site 316274011999 chain length determination region; other site 316274012000 substrate-Mg2+ binding site; other site 316274012001 catalytic residues [active] 316274012002 aspartate-rich region 1; other site 316274012003 active site lid residues [active] 316274012004 aspartate-rich region 2; other site 316274012005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274012006 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 316274012007 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316274012008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274012009 FeS/SAM binding site; other site 316274012010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274012011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274012012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274012013 6-phosphofructokinase; Provisional; Region: PRK03202 316274012014 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 316274012015 active site 316274012016 ADP/pyrophosphate binding site [chemical binding]; other site 316274012017 dimerization interface [polypeptide binding]; other site 316274012018 allosteric effector site; other site 316274012019 fructose-1,6-bisphosphate binding site; other site 316274012020 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274012021 glycogen synthase; Provisional; Region: glgA; PRK00654 316274012022 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316274012023 ADP-binding pocket [chemical binding]; other site 316274012024 homodimer interface [polypeptide binding]; other site 316274012025 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274012026 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 316274012027 G1 box; other site 316274012028 GTP/Mg2+ binding site [chemical binding]; other site 316274012029 G2 box; other site 316274012030 Switch I region; other site 316274012031 G3 box; other site 316274012032 Switch II region; other site 316274012033 G4 box; other site 316274012034 G5 box; other site 316274012035 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 316274012036 threonine synthase; Reviewed; Region: PRK06721 316274012037 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 316274012038 homodimer interface [polypeptide binding]; other site 316274012039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274012040 catalytic residue [active] 316274012041 aspartate kinase; Provisional; Region: PRK06291 316274012042 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 316274012043 nucleotide binding site [chemical binding]; other site 316274012044 substrate binding site [chemical binding]; other site 316274012045 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 316274012046 dimer interface [polypeptide binding]; other site 316274012047 putative threonine allosteric regulatory site; other site 316274012048 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 316274012049 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274012050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274012051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274012052 Coenzyme A binding pocket [chemical binding]; other site 316274012053 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 316274012054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 316274012055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 316274012056 NAD(P) binding site [chemical binding]; other site 316274012057 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 316274012058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012059 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 316274012060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274012061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274012062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274012063 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 316274012064 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 316274012065 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274012066 catalytic residue [active] 316274012067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012068 dimer interface [polypeptide binding]; other site 316274012069 phosphorylation site [posttranslational modification] 316274012070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012071 ATP binding site [chemical binding]; other site 316274012072 Mg2+ binding site [ion binding]; other site 316274012073 G-X-G motif; other site 316274012074 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 316274012075 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274012076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274012077 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 316274012078 nucleophilic elbow; other site 316274012079 catalytic triad; other site 316274012080 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 316274012081 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274012082 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274012083 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274012084 homodimer interface [polypeptide binding]; other site 316274012085 active site 316274012086 TDP-binding site; other site 316274012087 acceptor substrate-binding pocket; other site 316274012088 Putative esterase; Region: Esterase; pfam00756 316274012089 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274012090 arsenical pump membrane protein; Provisional; Region: PRK15445 316274012091 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 316274012092 transmembrane helices; other site 316274012093 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274012094 dimerization interface [polypeptide binding]; other site 316274012095 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274012096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012097 dimer interface [polypeptide binding]; other site 316274012098 phosphorylation site [posttranslational modification] 316274012099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012100 ATP binding site [chemical binding]; other site 316274012101 Mg2+ binding site [ion binding]; other site 316274012102 G-X-G motif; other site 316274012103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274012104 active site 316274012105 ATP binding site [chemical binding]; other site 316274012106 substrate binding site [chemical binding]; other site 316274012107 activation loop (A-loop); other site 316274012108 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274012109 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012110 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012111 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274012112 Protein kinase domain; Region: Pkinase; pfam00069 316274012113 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274012114 active site 316274012115 ATP binding site [chemical binding]; other site 316274012116 substrate binding site [chemical binding]; other site 316274012117 activation loop (A-loop); other site 316274012118 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274012119 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012120 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012121 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012122 translocation protein TolB; Provisional; Region: tolB; PRK04792 316274012123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274012124 active site 316274012125 ATP binding site [chemical binding]; other site 316274012126 substrate binding site [chemical binding]; other site 316274012127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274012128 TPR motif; other site 316274012129 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 316274012130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274012131 phosphopeptide binding site; other site 316274012132 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 316274012133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274012134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274012135 homodimer interface [polypeptide binding]; other site 316274012136 catalytic residue [active] 316274012137 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 316274012138 active site 316274012139 large tegument protein UL36; Provisional; Region: PHA03247 316274012140 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 316274012141 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 316274012142 Sulfatase; Region: Sulfatase; cl10460 316274012143 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274012144 Domain of unknown function DUF20; Region: UPF0118; cl00465 316274012145 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316274012146 metal binding site 2 [ion binding]; metal-binding site 316274012147 putative DNA binding helix; other site 316274012148 metal binding site 1 [ion binding]; metal-binding site 316274012149 dimer interface [polypeptide binding]; other site 316274012150 structural Zn2+ binding site [ion binding]; other site 316274012151 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 316274012152 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 316274012153 PAS domain S-box; Region: sensory_box; TIGR00229 316274012154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012155 GAF domain; Region: GAF; cl00853 316274012156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274012157 PAS fold; Region: PAS_3; pfam08447 316274012158 putative active site [active] 316274012159 heme pocket [chemical binding]; other site 316274012160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274012161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012162 dimer interface [polypeptide binding]; other site 316274012163 phosphorylation site [posttranslational modification] 316274012164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012165 ATP binding site [chemical binding]; other site 316274012166 Mg2+ binding site [ion binding]; other site 316274012167 G-X-G motif; other site 316274012168 Response regulator receiver domain; Region: Response_reg; pfam00072 316274012169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012170 active site 316274012171 phosphorylation site [posttranslational modification] 316274012172 intermolecular recognition site; other site 316274012173 dimerization interface [polypeptide binding]; other site 316274012174 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 316274012175 CHRD domain; Region: CHRD; cl06473 316274012176 CHRD domain; Region: CHRD; cl06473 316274012177 CHRD domain; Region: CHRD; cl06473 316274012178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274012179 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 316274012180 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274012181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274012182 ATP binding site [chemical binding]; other site 316274012183 putative Mg++ binding site [ion binding]; other site 316274012184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274012185 nucleotide binding region [chemical binding]; other site 316274012186 ATP-binding site [chemical binding]; other site 316274012187 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 316274012188 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 316274012189 HRDC domain; Region: HRDC; cl02578 316274012190 acetylornithine aminotransferase; Provisional; Region: PRK02627 316274012191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 316274012192 inhibitor-cofactor binding pocket; inhibition site 316274012193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274012194 catalytic residue [active] 316274012195 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 316274012196 putative ADP-ribose binding site [chemical binding]; other site 316274012197 putative active site [active] 316274012198 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 316274012199 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 316274012200 aspartate racemase; Region: asp_race; TIGR00035 316274012201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274012202 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 316274012203 TPR motif; other site 316274012204 binding surface 316274012205 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 316274012206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 316274012207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274012208 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274012209 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 316274012210 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274012211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274012212 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316274012213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 316274012214 dimer interface [polypeptide binding]; other site 316274012215 conserved gate region; other site 316274012216 putative PBP binding loops; other site 316274012217 ABC-ATPase subunit interface; other site 316274012218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274012219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274012220 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 316274012221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274012222 CoA-ligase; Region: Ligase_CoA; pfam00549 316274012223 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274012224 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274012225 NADP-binding site; other site 316274012226 homotetramer interface [polypeptide binding]; other site 316274012227 substrate binding site [chemical binding]; other site 316274012228 homodimer interface [polypeptide binding]; other site 316274012229 active site 316274012230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274012231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274012232 non-specific DNA binding site [nucleotide binding]; other site 316274012233 salt bridge; other site 316274012234 sequence-specific DNA binding site [nucleotide binding]; other site 316274012235 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 316274012236 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274012237 CoA-ligase; Region: Ligase_CoA; pfam00549 316274012238 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 316274012239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274012240 amidophosphoribosyltransferase; Region: purF; TIGR01134 316274012241 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 316274012242 active site 316274012243 tetramer interface [polypeptide binding]; other site 316274012244 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 316274012245 Anti-sigma-K factor rskA; Region: RskA; cl02208 316274012246 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274012247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274012248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274012249 DNA binding residues [nucleotide binding] 316274012250 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 316274012251 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 316274012252 putative sugar binding sites [chemical binding]; other site 316274012253 Q-X-W motif; other site 316274012254 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 316274012255 putative sugar binding sites [chemical binding]; other site 316274012256 Q-X-W motif; other site 316274012257 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 316274012258 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 316274012259 G1 box; other site 316274012260 putative GEF interaction site [polypeptide binding]; other site 316274012261 GTP/Mg2+ binding site [chemical binding]; other site 316274012262 Switch I region; other site 316274012263 G2 box; other site 316274012264 G3 box; other site 316274012265 Switch II region; other site 316274012266 G4 box; other site 316274012267 G5 box; other site 316274012268 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 316274012269 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 316274012270 Restriction endonuclease; Region: Mrr_cat; cl00747 316274012271 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274012272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274012273 ABC-2 type transporter; Region: ABC2_membrane; cl11417 316274012274 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 316274012275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274012276 Walker A/P-loop; other site 316274012277 ATP binding site [chemical binding]; other site 316274012278 Q-loop/lid; other site 316274012279 ABC transporter signature motif; other site 316274012280 Walker B; other site 316274012281 D-loop; other site 316274012282 H-loop/switch region; other site 316274012283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 316274012284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274012285 dimerization interface [polypeptide binding]; other site 316274012286 putative DNA binding site [nucleotide binding]; other site 316274012287 putative Zn2+ binding site [ion binding]; other site 316274012288 Cation efflux family; Region: Cation_efflux; cl00316 316274012289 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316274012290 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 316274012291 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 316274012292 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 316274012293 Low molecular weight phosphatase family; Region: LMWPc; cd00115 316274012294 Active site [active] 316274012295 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 316274012296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 316274012297 active site 316274012298 catalytic tetrad [active] 316274012299 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 316274012300 active site 316274012301 catalytic motif [active] 316274012302 Zn binding site [ion binding]; other site 316274012303 Domain of unknown function DUF21; Region: DUF21; pfam01595 316274012304 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316274012305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316274012306 Transporter associated domain; Region: CorC_HlyC; pfam03471 316274012307 aspartate aminotransferase; Provisional; Region: PRK08361 316274012308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274012309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274012310 homodimer interface [polypeptide binding]; other site 316274012311 catalytic residue [active] 316274012312 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274012313 Ligand binding site [chemical binding]; other site 316274012314 Putative Catalytic site [active] 316274012315 DXD motif; other site 316274012316 adenylosuccinate synthetase; Provisional; Region: PRK01117 316274012317 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 316274012318 GDP-binding site [chemical binding]; other site 316274012319 ACT binding site; other site 316274012320 IMP binding site; other site 316274012321 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 316274012322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274012323 Walker A/P-loop; other site 316274012324 ATP binding site [chemical binding]; other site 316274012325 Q-loop/lid; other site 316274012326 ABC transporter signature motif; other site 316274012327 Walker B; other site 316274012328 D-loop; other site 316274012329 H-loop/switch region; other site 316274012330 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274012331 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 316274012332 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 316274012333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274012334 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 316274012335 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274012336 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274012337 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274012338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274012339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 316274012340 CHRD domain; Region: CHRD; cl06473 316274012341 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012342 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274012343 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274012344 active site 316274012345 ATP binding site [chemical binding]; other site 316274012346 substrate binding site [chemical binding]; other site 316274012347 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274012348 activation loop (A-loop); other site 316274012349 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 316274012350 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274012351 active site 316274012352 DNA binding site [nucleotide binding] 316274012353 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 316274012354 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 316274012355 putative catalytic cysteine [active] 316274012356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274012357 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 316274012358 FAD binding site [chemical binding]; other site 316274012359 homotetramer interface [polypeptide binding]; other site 316274012360 substrate binding pocket [chemical binding]; other site 316274012361 catalytic base [active] 316274012362 Response regulator receiver domain; Region: Response_reg; pfam00072 316274012363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012364 active site 316274012365 phosphorylation site [posttranslational modification] 316274012366 intermolecular recognition site; other site 316274012367 dimerization interface [polypeptide binding]; other site 316274012368 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 316274012369 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274012370 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 316274012371 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 316274012372 ATP binding site [chemical binding]; other site 316274012373 Walker A motif; other site 316274012374 hexamer interface [polypeptide binding]; other site 316274012375 Walker B motif; other site 316274012376 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 316274012377 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 316274012378 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 316274012379 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 316274012380 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 316274012381 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316274012382 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 316274012383 RimM N-terminal domain; Region: RimM; pfam01782 316274012384 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 316274012385 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 316274012386 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 316274012387 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 316274012388 signal recognition particle protein; Provisional; Region: PRK10867 316274012389 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 316274012390 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316274012391 P loop; other site 316274012392 GTP binding site [chemical binding]; other site 316274012393 Signal peptide binding domain; Region: SRP_SPB; pfam02978 316274012394 DoxX; Region: DoxX; cl00976 316274012395 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 316274012396 DNA gyrase subunit A; Validated; Region: PRK05560 316274012397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 316274012398 CAP-like domain; other site 316274012399 Active site [active] 316274012400 primary dimer interface [polypeptide binding]; other site 316274012401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274012407 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 316274012408 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274012409 active sites [active] 316274012410 tetramer interface [polypeptide binding]; other site 316274012411 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 316274012412 active site 316274012413 DinB superfamily; Region: DinB_2; cl00986 316274012414 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 316274012415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274012416 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 316274012417 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 316274012418 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 316274012419 putative tRNA-binding site [nucleotide binding]; other site 316274012420 B3/4 domain; Region: B3_4; cl11458 316274012421 tRNA synthetase B5 domain; Region: B5; cl08394 316274012422 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 316274012423 dimer interface [polypeptide binding]; other site 316274012424 motif 1; other site 316274012425 motif 3; other site 316274012426 motif 2; other site 316274012427 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 316274012428 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 316274012429 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 316274012430 tetramer interface [polypeptide binding]; other site 316274012431 TPP-binding site [chemical binding]; other site 316274012432 heterodimer interface [polypeptide binding]; other site 316274012433 phosphorylation loop region [posttranslational modification] 316274012434 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 316274012435 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 316274012436 alpha subunit interface [polypeptide binding]; other site 316274012437 TPP binding site [chemical binding]; other site 316274012438 heterodimer interface [polypeptide binding]; other site 316274012439 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274012440 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274012441 E3 interaction surface; other site 316274012442 lipoyl attachment site [posttranslational modification]; other site 316274012443 e3 binding domain; Region: E3_binding; pfam02817 316274012444 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 316274012445 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 316274012446 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274012447 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316274012448 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 316274012449 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 316274012450 23S rRNA binding site [nucleotide binding]; other site 316274012451 L21 binding site [polypeptide binding]; other site 316274012452 L13 binding site [polypeptide binding]; other site 316274012453 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 316274012454 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 316274012455 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 316274012456 Endodeoxyribonuclease RusA; Region: RusA; cl01885 316274012457 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274012458 active site 316274012459 catalytic site [active] 316274012460 Peptidase family C25; Region: Peptidase_C25; pfam01364 316274012461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 316274012462 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 316274012463 FeS/SAM binding site; other site 316274012464 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 316274012465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274012466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012467 active site 316274012468 phosphorylation site [posttranslational modification] 316274012469 intermolecular recognition site; other site 316274012470 dimerization interface [polypeptide binding]; other site 316274012471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274012472 DNA binding residues [nucleotide binding] 316274012473 dimerization interface [polypeptide binding]; other site 316274012474 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012475 GAF domain; Region: GAF; cl00853 316274012476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274012477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012478 dimer interface [polypeptide binding]; other site 316274012479 phosphorylation site [posttranslational modification] 316274012480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012481 ATP binding site [chemical binding]; other site 316274012482 Mg2+ binding site [ion binding]; other site 316274012483 G-X-G motif; other site 316274012484 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 316274012485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274012486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 316274012487 DNA binding residues [nucleotide binding] 316274012488 Anti-sigma-K factor rskA; Region: RskA; cl02208 316274012489 Anti-sigma-K factor rskA; Region: RskA; cl02208 316274012490 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 316274012491 active site 316274012492 catalytic triad [active] 316274012493 Membrane protein of unknown function; Region: DUF360; cl00850 316274012494 RDD family; Region: RDD; cl00746 316274012495 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012496 GAF domain; Region: GAF; cl00853 316274012497 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274012498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274012499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012500 dimer interface [polypeptide binding]; other site 316274012501 phosphorylation site [posttranslational modification] 316274012502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012503 ATP binding site [chemical binding]; other site 316274012504 Mg2+ binding site [ion binding]; other site 316274012505 G-X-G motif; other site 316274012506 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 316274012507 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274012508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274012509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012510 dimer interface [polypeptide binding]; other site 316274012511 phosphorylation site [posttranslational modification] 316274012512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012513 ATP binding site [chemical binding]; other site 316274012514 Mg2+ binding site [ion binding]; other site 316274012515 G-X-G motif; other site 316274012516 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 316274012517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 316274012518 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 316274012519 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 316274012520 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274012521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274012522 putative substrate translocation pore; other site 316274012523 Electron transfer DM13; Region: DM13; cl02735 316274012524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274012525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012526 active site 316274012527 phosphorylation site [posttranslational modification] 316274012528 intermolecular recognition site; other site 316274012529 dimerization interface [polypeptide binding]; other site 316274012530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 316274012531 DNA binding site [nucleotide binding] 316274012532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274012533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012534 dimer interface [polypeptide binding]; other site 316274012535 phosphorylation site [posttranslational modification] 316274012536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012537 ATP binding site [chemical binding]; other site 316274012538 Mg2+ binding site [ion binding]; other site 316274012539 G-X-G motif; other site 316274012540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012541 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274012542 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 316274012543 putative active site pocket [active] 316274012544 4-fold oligomerization interface [polypeptide binding]; other site 316274012545 metal binding residues [ion binding]; metal-binding site 316274012546 3-fold/trimer interface [polypeptide binding]; other site 316274012547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274012548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274012549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274012550 PspC domain; Region: PspC; cl00864 316274012551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274012552 putative DNA binding site [nucleotide binding]; other site 316274012553 dimerization interface [polypeptide binding]; other site 316274012554 putative Zn2+ binding site [ion binding]; other site 316274012555 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274012556 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274012557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274012558 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274012559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 316274012560 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316274012561 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 316274012562 putative [4Fe-4S] binding site [ion binding]; other site 316274012563 putative molybdopterin cofactor binding site [chemical binding]; other site 316274012564 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 316274012565 putative molybdopterin cofactor binding site; other site 316274012566 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 316274012567 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 316274012568 active site 316274012569 dimer interface [polypeptide binding]; other site 316274012570 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 316274012571 dimer interface [polypeptide binding]; other site 316274012572 active site 316274012573 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 316274012574 putative active site; other site 316274012575 putative metal binding residues [ion binding]; other site 316274012576 signature motif; other site 316274012577 putative triphosphate binding site [ion binding]; other site 316274012578 CHAD domain; Region: CHAD; cl10506 316274012579 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 316274012580 putative RNAase interaction site [polypeptide binding]; other site 316274012581 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 316274012582 active site 316274012583 barstar interaction site; other site 316274012584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 316274012585 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274012586 putative ligand binding site [chemical binding]; other site 316274012587 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316274012588 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 316274012589 active site 316274012590 Zn binding site [ion binding]; other site 316274012591 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274012592 peptide binding site [polypeptide binding]; other site 316274012593 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274012594 dimer interface [polypeptide binding]; other site 316274012595 Preprotein translocase SecG subunit; Region: SecG; cl09123 316274012596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274012597 Zn2+ binding site [ion binding]; other site 316274012598 Mg2+ binding site [ion binding]; other site 316274012599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274012600 YacP-like NYN domain; Region: NYN_YacP; cl01491 316274012601 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 316274012602 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 316274012603 homotetramer interface [polypeptide binding]; other site 316274012604 FMN binding site [chemical binding]; other site 316274012605 homodimer contacts [polypeptide binding]; other site 316274012606 putative active site [active] 316274012607 putative substrate binding site [chemical binding]; other site 316274012608 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274012609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274012610 Coenzyme A binding pocket [chemical binding]; other site 316274012611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274012612 Transglycosylase; Region: Transgly; cl07896 316274012613 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 316274012614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 316274012615 Survival protein SurE; Region: SurE; cl00448 316274012616 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274012617 GTP-binding protein YchF; Reviewed; Region: PRK09601 316274012618 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 316274012619 G1 box; other site 316274012620 GTP/Mg2+ binding site [chemical binding]; other site 316274012621 Switch I region; other site 316274012622 G2 box; other site 316274012623 Switch II region; other site 316274012624 G3 box; other site 316274012625 G4 box; other site 316274012626 G5 box; other site 316274012627 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 316274012628 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 316274012629 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274012630 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 316274012631 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 316274012632 active site 316274012633 substrate binding site [chemical binding]; other site 316274012634 metal binding site [ion binding]; metal-binding site 316274012635 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274012636 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 316274012637 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 316274012638 Int/Topo IB signature motif; other site 316274012639 active site 316274012640 glycyl-tRNA synthetase; Provisional; Region: PRK04173 316274012641 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 316274012642 dimer interface [polypeptide binding]; other site 316274012643 motif 1; other site 316274012644 active site 316274012645 motif 2; other site 316274012646 motif 3; other site 316274012647 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 316274012648 anticodon binding site; other site 316274012649 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274012651 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 316274012652 NAD(P) binding site [chemical binding]; other site 316274012653 active site 316274012654 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 316274012655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274012656 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316274012657 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 316274012658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274012659 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274012660 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 316274012661 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 316274012662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 316274012663 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274012664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274012665 Walker A/P-loop; other site 316274012666 ATP binding site [chemical binding]; other site 316274012667 Q-loop/lid; other site 316274012668 ABC transporter signature motif; other site 316274012669 Walker B; other site 316274012670 D-loop; other site 316274012671 H-loop/switch region; other site 316274012672 Histidine kinase; Region: HisKA_3; pfam07730 316274012673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274012674 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 316274012675 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 316274012676 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274012677 active site 316274012678 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 316274012679 catalytic triad [active] 316274012680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274012681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274012682 DNA binding site [nucleotide binding] 316274012683 domain linker motif; other site 316274012684 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 316274012685 putative dimerization interface [polypeptide binding]; other site 316274012686 putative ligand binding site [chemical binding]; other site 316274012687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316274012688 active site 316274012689 phosphorylation site [posttranslational modification] 316274012690 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316274012691 dimerization domain swap beta strand [polypeptide binding]; other site 316274012692 regulatory protein interface [polypeptide binding]; other site 316274012693 active site 316274012694 regulatory phosphorylation site [posttranslational modification]; other site 316274012695 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 316274012696 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316274012697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 316274012698 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 316274012699 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 316274012700 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 316274012701 putative substrate binding site [chemical binding]; other site 316274012702 putative ATP binding site [chemical binding]; other site 316274012703 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 316274012704 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 316274012705 P-loop; other site 316274012706 active site 316274012707 phosphorylation site [posttranslational modification] 316274012708 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 316274012709 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316274012710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274012711 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 316274012712 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 316274012713 ligand binding site [chemical binding]; other site 316274012714 oligomer interface [polypeptide binding]; other site 316274012715 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 316274012716 dimer interface [polypeptide binding]; other site 316274012717 N-terminal domain interface [polypeptide binding]; other site 316274012718 sulfate 1 binding site; other site 316274012719 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 316274012720 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 316274012721 ligand binding site [chemical binding]; other site 316274012722 oligomer interface [polypeptide binding]; other site 316274012723 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 316274012724 dimer interface [polypeptide binding]; other site 316274012725 N-terminal domain interface [polypeptide binding]; other site 316274012726 sulfate 1 binding site; other site 316274012727 DinB superfamily; Region: DinB_2; cl00986 316274012728 DinB superfamily; Region: DinB_2; cl00986 316274012729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274012730 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274012731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274012732 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 316274012733 catalytic triad [active] 316274012734 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 316274012735 catalytic triad [active] 316274012736 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274012737 Predicted ATPase [General function prediction only]; Region: COG3899 316274012738 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274012739 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316274012740 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 316274012741 active site 316274012742 elongation factor P; Validated; Region: PRK00529 316274012743 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316274012744 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 316274012745 RNA binding site [nucleotide binding]; other site 316274012746 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 316274012747 RNA binding site [nucleotide binding]; other site 316274012748 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 316274012749 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 316274012750 carboxyltransferase (CT) interaction site; other site 316274012751 biotinylation site [posttranslational modification]; other site 316274012752 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 316274012753 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 316274012754 generic binding surface II; other site 316274012755 generic binding surface I; other site 316274012756 Predicted ATPase [General function prediction only]; Region: COG3910 316274012757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274012758 Walker A/P-loop; other site 316274012759 ATP binding site [chemical binding]; other site 316274012760 Q-loop/lid; other site 316274012761 ABC transporter signature motif; other site 316274012762 Walker B; other site 316274012763 D-loop; other site 316274012764 H-loop/switch region; other site 316274012765 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like; cd06192 316274012766 FAD binding pocket [chemical binding]; other site 316274012767 FAD binding motif [chemical binding]; other site 316274012768 phosphate binding motif [ion binding]; other site 316274012769 beta-alpha-beta structure motif; other site 316274012770 NAD binding pocket [chemical binding]; other site 316274012771 Iron coordination center [ion binding]; other site 316274012772 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 316274012773 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 316274012774 Glutamate binding site [chemical binding]; other site 316274012775 homodimer interface [polypeptide binding]; other site 316274012776 NAD binding site [chemical binding]; other site 316274012777 catalytic residues [active] 316274012778 Response regulator receiver domain; Region: Response_reg; pfam00072 316274012779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012780 active site 316274012781 phosphorylation site [posttranslational modification] 316274012782 intermolecular recognition site; other site 316274012783 dimerization interface [polypeptide binding]; other site 316274012784 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 316274012785 nudix motif; other site 316274012786 Transposase IS200 like; Region: Y1_Tnp; cl00848 316274012787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274012788 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274012789 Probable transposase; Region: OrfB_IS605; pfam01385 316274012790 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 316274012791 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 316274012792 putative FMN binding site [chemical binding]; other site 316274012793 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274012794 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274012795 Probable Catalytic site [active] 316274012796 metal binding site [ion binding]; metal-binding site 316274012797 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 316274012798 Uncharacterized conserved protein [Function unknown]; Region: COG1543 316274012799 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 316274012800 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274012801 Active site [active] 316274012802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274012803 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 316274012804 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 316274012805 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274012806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274012807 oligoendopeptidase F; Region: pepF; TIGR00181 316274012808 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 316274012809 active site 316274012810 Zn binding site [ion binding]; other site 316274012811 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 316274012812 active site 316274012813 putative DNA-binding cleft [nucleotide binding]; other site 316274012814 dimer interface [polypeptide binding]; other site 316274012815 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 316274012816 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274012817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274012818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274012819 active site 316274012820 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 316274012821 Aspartase; Region: Aspartase; cd01357 316274012822 active sites [active] 316274012823 tetramer interface [polypeptide binding]; other site 316274012824 WGR domain; Region: WGR; cl01581 316274012825 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the...; Region: ADP_ribosyl; cl00283 316274012826 nad+ binding pocket [chemical binding]; other site 316274012827 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 316274012828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274012829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274012830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274012831 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 316274012832 active site 316274012833 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274012834 dimer interface [polypeptide binding]; other site 316274012835 substrate binding site [chemical binding]; other site 316274012836 catalytic residues [active] 316274012837 ATP cone domain; Region: ATP-cone; pfam03477 316274012838 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 316274012839 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 316274012840 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 316274012841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274012842 dimer interface [polypeptide binding]; other site 316274012843 phosphorylation site [posttranslational modification] 316274012844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012845 ATP binding site [chemical binding]; other site 316274012846 Mg2+ binding site [ion binding]; other site 316274012847 G-X-G motif; other site 316274012848 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012849 GAF domain; Region: GAF; cl00853 316274012850 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012851 GAF domain; Region: GAF; cl00853 316274012852 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012853 GAF domain; Region: GAF; cl00853 316274012854 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012855 GAF domain; Region: GAF; cl00853 316274012856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012857 GAF domain; Region: GAF; cl00853 316274012858 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012859 GAF domain; Region: GAF; cl00853 316274012860 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012861 GAF domain; Region: GAF; cl00853 316274012862 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 316274012863 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274012864 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 316274012865 intersubunit interface [polypeptide binding]; other site 316274012866 active site 316274012867 Zn2+ binding site [ion binding]; other site 316274012868 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012869 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316274012870 FAD binding domain; Region: FAD_binding_4; pfam01565 316274012871 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 316274012872 Predicted amidohydrolase [General function prediction only]; Region: COG0388 316274012873 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 316274012874 putative active site [active] 316274012875 catalytic triad [active] 316274012876 putative dimer interface [polypeptide binding]; other site 316274012877 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 316274012878 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274012879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 316274012880 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274012881 rod shape-determining protein MreC; Region: MreC; pfam04085 316274012882 rod shape-determining protein MreB; Provisional; Region: PRK13927 316274012883 Cell division protein FtsA; Region: FtsA; cl11496 316274012884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274012885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274012886 active site 316274012887 phosphorylation site [posttranslational modification] 316274012888 intermolecular recognition site; other site 316274012889 dimerization interface [polypeptide binding]; other site 316274012890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274012891 DNA binding residues [nucleotide binding] 316274012892 dimerization interface [polypeptide binding]; other site 316274012893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274012894 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274012895 putative substrate translocation pore; other site 316274012896 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274012897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274012898 S-adenosylmethionine binding site [chemical binding]; other site 316274012899 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316274012900 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 316274012901 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274012902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274012903 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274012904 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274012905 active site 316274012906 metal binding site [ion binding]; metal-binding site 316274012907 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274012908 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316274012909 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274012910 active site 316274012911 ATP binding site [chemical binding]; other site 316274012912 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274012913 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274012914 putative active site [active] 316274012915 putative NTP binding site [chemical binding]; other site 316274012916 putative nucleic acid binding site [nucleotide binding]; other site 316274012917 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274012918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 316274012919 active site 316274012920 phosphodiesterase; Provisional; Region: PRK12704 316274012921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274012922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 316274012923 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 316274012924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274012925 active site 316274012926 ATP binding site [chemical binding]; other site 316274012927 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274012928 substrate binding site [chemical binding]; other site 316274012929 activation loop (A-loop); other site 316274012930 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274012931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274012932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274012933 DNA binding site [nucleotide binding] 316274012934 domain linker motif; other site 316274012935 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274012936 ligand binding site [chemical binding]; other site 316274012937 dimerization interface [polypeptide binding]; other site 316274012938 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 316274012939 putative substrate binding site [chemical binding]; other site 316274012940 putative ATP binding site [chemical binding]; other site 316274012941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274012942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274012943 putative substrate translocation pore; other site 316274012944 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 316274012945 active site 316274012946 oxyanion hole [active] 316274012947 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274012948 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274012949 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274012950 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274012951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274012952 active site 316274012953 metal binding site [ion binding]; metal-binding site 316274012954 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274012955 Cellulose binding domain; Region: CBM_2; cl02709 316274012956 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316274012957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012958 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274012959 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 316274012960 ParB-like nuclease domain; Region: ParBc; cl02129 316274012961 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274012962 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 316274012963 P-loop; other site 316274012964 Magnesium ion binding site [ion binding]; other site 316274012965 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 316274012966 Magnesium ion binding site [ion binding]; other site 316274012967 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 316274012968 MPT binding site; other site 316274012969 trimer interface [polypeptide binding]; other site 316274012970 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274012971 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274012972 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 316274012973 Ferritin-like domain; Region: Ferritin; pfam00210 316274012974 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 316274012975 dimerization interface [polypeptide binding]; other site 316274012976 DPS ferroxidase diiron center [ion binding]; other site 316274012977 ion pore; other site 316274012978 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 316274012979 putative metal binding site [ion binding]; other site 316274012980 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 316274012981 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 316274012982 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 316274012983 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 316274012984 nudix motif; other site 316274012985 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274012986 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274012987 NADP-binding site; other site 316274012988 homotetramer interface [polypeptide binding]; other site 316274012989 substrate binding site [chemical binding]; other site 316274012990 homodimer interface [polypeptide binding]; other site 316274012991 active site 316274012992 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 316274012993 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 316274012994 Substrate binding site [chemical binding]; other site 316274012995 Cupin domain; Region: Cupin_2; cl09118 316274012996 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 316274012997 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274012998 active site 316274012999 Substrate binding site [chemical binding]; other site 316274013000 Mg++ binding site [ion binding]; other site 316274013001 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316274013002 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800 316274013003 active site 316274013004 substrate binding site [chemical binding]; other site 316274013005 metal binding site [ion binding]; metal-binding site 316274013006 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: NADH_oxidase; cd03370 316274013007 dimer interface [polypeptide binding]; other site 316274013008 FMN binding site [chemical binding]; other site 316274013009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274013010 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 316274013011 Flavoprotein; Region: Flavoprotein; cl08021 316274013012 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 316274013013 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 316274013014 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 316274013015 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 316274013016 protein binding site [polypeptide binding]; other site 316274013017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274013018 non-specific DNA binding site [nucleotide binding]; other site 316274013019 salt bridge; other site 316274013020 sequence-specific DNA binding site [nucleotide binding]; other site 316274013021 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274013022 pyruvate carboxylase; Region: pyruv_carbox; TIGR01235 316274013023 Domain of unknown function (DUF407); Region: DUF407; pfam04174 316274013024 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 316274013025 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 316274013026 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 316274013027 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 316274013028 putative active site [active] 316274013029 substrate binding site [chemical binding]; other site 316274013030 putative cosubstrate binding site; other site 316274013031 catalytic site [active] 316274013032 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 316274013033 substrate binding site [chemical binding]; other site 316274013034 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 316274013035 DHH family; Region: DHH; pfam01368 316274013036 DHHA1 domain; Region: DHHA1; pfam02272 316274013037 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 316274013038 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 316274013039 ATP binding site [chemical binding]; other site 316274013040 active site 316274013041 substrate binding site [chemical binding]; other site 316274013042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274013043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274013044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274013045 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 316274013046 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 316274013047 putative active site [active] 316274013048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274013049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 316274013050 P-loop; other site 316274013051 Magnesium ion binding site [ion binding]; other site 316274013052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 316274013053 Magnesium ion binding site [ion binding]; other site 316274013054 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 316274013055 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 316274013056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013057 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 316274013058 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 316274013059 substrate binding site [chemical binding]; other site 316274013060 hinge regions; other site 316274013061 ADP binding site [chemical binding]; other site 316274013062 catalytic site [active] 316274013063 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 316274013064 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 316274013065 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 316274013066 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013067 GAF domain; Region: GAF; cl00853 316274013068 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274013069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274013070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274013071 dimer interface [polypeptide binding]; other site 316274013072 phosphorylation site [posttranslational modification] 316274013073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013074 ATP binding site [chemical binding]; other site 316274013075 Mg2+ binding site [ion binding]; other site 316274013076 G-X-G motif; other site 316274013077 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274013078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274013079 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 316274013080 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 316274013081 dimerization interface [polypeptide binding]; other site 316274013082 putative ATP binding site [chemical binding]; other site 316274013083 Arginase family; Region: Arginase; cl00306 316274013084 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013085 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 316274013086 trimer interface [polypeptide binding]; other site 316274013087 dimer interface [polypeptide binding]; other site 316274013088 putative active site [active] 316274013089 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 316274013090 active site 316274013091 nucleophile elbow; other site 316274013092 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 316274013093 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316274013094 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 316274013095 PspC domain; Region: PspC; cl00864 316274013096 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 316274013097 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 316274013098 active site 316274013099 putative substrate binding pocket [chemical binding]; other site 316274013100 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 316274013101 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316274013102 putative active site [active] 316274013103 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 316274013104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274013105 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316274013106 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 316274013107 dimer interface [polypeptide binding]; other site 316274013108 motif 1; other site 316274013109 active site 316274013110 motif 2; other site 316274013111 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 316274013112 putative deacylase active site [active] 316274013113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274013114 active site 316274013115 motif 3; other site 316274013116 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 316274013117 anticodon binding site; other site 316274013118 Protein of unknown function (DUF328); Region: DUF328; cl01143 316274013119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274013120 substrate binding pocket [chemical binding]; other site 316274013121 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 316274013122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 316274013123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013124 ATP binding site [chemical binding]; other site 316274013125 Mg2+ binding site [ion binding]; other site 316274013126 G-X-G motif; other site 316274013127 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 316274013128 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 316274013129 ATP binding site [chemical binding]; other site 316274013130 substrate interface [chemical binding]; other site 316274013131 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 316274013132 Mg++ binding site [ion binding]; other site 316274013133 putative catalytic motif [active] 316274013134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013135 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013136 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274013137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 316274013138 motif II; other site 316274013139 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 316274013140 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 316274013141 Zn binding site [ion binding]; other site 316274013142 Integral membrane protein DUF92; Region: DUF92; cl00793 316274013143 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 316274013144 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 316274013145 oligomer interface [polypeptide binding]; other site 316274013146 active site 316274013147 metal binding site [ion binding]; metal-binding site 316274013148 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274013149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 316274013150 S-adenosylmethionine binding site [chemical binding]; other site 316274013151 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 316274013152 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 316274013153 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 316274013154 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl00804 316274013155 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 316274013156 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 316274013157 Walker A/P-loop; other site 316274013158 ATP binding site [chemical binding]; other site 316274013159 Q-loop/lid; other site 316274013160 ABC transporter signature motif; other site 316274013161 Walker B; other site 316274013162 D-loop; other site 316274013163 H-loop/switch region; other site 316274013164 Smr domain; Region: Smr; cl02619 316274013165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274013166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013167 ATP binding site [chemical binding]; other site 316274013168 Mg2+ binding site [ion binding]; other site 316274013169 G-X-G motif; other site 316274013170 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 316274013171 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 316274013172 Substrate-binding site [chemical binding]; other site 316274013173 Substrate specificity [chemical binding]; other site 316274013174 Uncharacterized conserved protein [Function unknown]; Region: COG1284 316274013175 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274013176 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 316274013177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274013178 Histidine kinase; Region: HisKA_3; pfam07730 316274013179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274013180 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274013181 putative catalytic residues [active] 316274013182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013183 TPR motif; other site 316274013184 binding surface 316274013185 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274013186 metal ion-dependent adhesion site (MIDAS); other site 316274013187 Aerotolerance regulator N-terminal; Region: BatA; cl06567 316274013188 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 316274013189 metal ion-dependent adhesion site (MIDAS); other site 316274013190 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274013191 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274013192 metal ion-dependent adhesion site (MIDAS); other site 316274013193 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274013194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274013195 Walker A motif; other site 316274013196 ATP binding site [chemical binding]; other site 316274013197 Walker B motif; other site 316274013198 arginine finger; other site 316274013199 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 316274013200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274013201 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 316274013202 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 316274013203 dimerization interface [polypeptide binding]; other site 316274013204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 316274013205 dimer interface [polypeptide binding]; other site 316274013206 phosphorylation site [posttranslational modification] 316274013207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013208 ATP binding site [chemical binding]; other site 316274013209 Mg2+ binding site [ion binding]; other site 316274013210 G-X-G motif; other site 316274013211 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274013213 active site 316274013214 phosphorylation site [posttranslational modification] 316274013215 intermolecular recognition site; other site 316274013216 dimerization interface [polypeptide binding]; other site 316274013217 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274013218 Sensor protein DegS; Region: DegS; pfam05384 316274013219 Histidine kinase; Region: HisKA_3; pfam07730 316274013220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274013221 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 316274013222 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274013223 dimer interface [polypeptide binding]; other site 316274013224 active site 316274013225 Protein of unknown function DUF72; Region: DUF72; cl00777 316274013226 elongation factor Tu; Reviewed; Region: PRK00049 316274013227 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 316274013228 G1 box; other site 316274013229 GEF interaction site [polypeptide binding]; other site 316274013230 GTP/Mg2+ binding site [chemical binding]; other site 316274013231 Switch I region; other site 316274013232 G2 box; other site 316274013233 G3 box; other site 316274013234 Switch II region; other site 316274013235 G4 box; other site 316274013236 G5 box; other site 316274013237 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316274013238 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 316274013239 Antibiotic Binding Site [chemical binding]; other site 316274013240 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 316274013241 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 316274013242 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 316274013243 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 316274013244 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 316274013245 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 316274013246 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 316274013247 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 316274013248 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 316274013249 putative translocon binding site; other site 316274013250 protein-rRNA interface [nucleotide binding]; other site 316274013251 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 316274013252 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 316274013253 G-X-X-G motif; other site 316274013254 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 316274013255 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 316274013256 23S rRNA interface [nucleotide binding]; other site 316274013257 5S rRNA interface [nucleotide binding]; other site 316274013258 putative antibiotic binding site [chemical binding]; other site 316274013259 L25 interface [polypeptide binding]; other site 316274013260 L27 interface [polypeptide binding]; other site 316274013261 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 316274013262 23S rRNA interface [nucleotide binding]; other site 316274013263 putative translocon interaction site; other site 316274013264 signal recognition particle (SRP54) interaction site; other site 316274013265 L23 interface [polypeptide binding]; other site 316274013266 trigger factor interaction site; other site 316274013267 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 316274013268 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 316274013269 KOW motif; Region: KOW; cl00354 316274013270 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 316274013271 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 316274013272 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 316274013273 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 316274013274 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 316274013275 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 316274013276 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316274013277 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316274013278 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 316274013279 23S rRNA interface [nucleotide binding]; other site 316274013280 5S rRNA interface [nucleotide binding]; other site 316274013281 L27 interface [polypeptide binding]; other site 316274013282 L5 interface [polypeptide binding]; other site 316274013283 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 316274013284 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 316274013285 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 316274013286 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 316274013287 23S rRNA binding site [nucleotide binding]; other site 316274013288 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 316274013289 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 316274013290 SecY translocase; Region: SecY; pfam00344 316274013291 adenylate kinase; Reviewed; Region: adk; PRK00279 316274013292 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316274013293 AMP-binding site [chemical binding]; other site 316274013294 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316274013295 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 316274013296 rRNA binding site [nucleotide binding]; other site 316274013297 predicted 30S ribosome binding site; other site 316274013298 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 316274013299 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 316274013300 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 316274013301 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 316274013302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274013303 RNA binding surface [nucleotide binding]; other site 316274013304 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 316274013305 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 316274013306 alphaNTD homodimer interface [polypeptide binding]; other site 316274013307 alphaNTD - beta interaction site [polypeptide binding]; other site 316274013308 alphaNTD - beta' interaction site [polypeptide binding]; other site 316274013309 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 316274013310 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 316274013311 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 316274013312 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 316274013313 dimerization interface 3.5A [polypeptide binding]; other site 316274013314 active site 316274013315 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 316274013316 23S rRNA interface [nucleotide binding]; other site 316274013317 L3 interface [polypeptide binding]; other site 316274013318 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 316274013319 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274013320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013321 Walker A/P-loop; other site 316274013322 ATP binding site [chemical binding]; other site 316274013323 Q-loop/lid; other site 316274013324 ABC transporter signature motif; other site 316274013325 Walker B; other site 316274013326 D-loop; other site 316274013327 H-loop/switch region; other site 316274013328 ABC transporter; Region: ABC_tran_2; pfam12848 316274013329 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 316274013330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 316274013331 Predicted membrane protein [Function unknown]; Region: COG2364 316274013332 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274013333 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274013334 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274013335 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274013336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 316274013337 protein binding site [polypeptide binding]; other site 316274013338 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 316274013339 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 316274013340 metal binding site [ion binding]; metal-binding site 316274013341 dimer interface [polypeptide binding]; other site 316274013342 Calx-beta domain; Region: Calx-beta; cl02522 316274013343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274013344 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274013345 Phage Tail Collar Domain; Region: Collar; pfam07484 316274013346 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274013347 Phage Tail Collar Domain; Region: Collar; pfam07484 316274013348 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274013349 Phage Tail Collar Domain; Region: Collar; pfam07484 316274013350 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274013351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 316274013352 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274013353 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 316274013354 hinge region; other site 316274013355 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 316274013356 putative nucleotide binding site [chemical binding]; other site 316274013357 uridine monophosphate binding site [chemical binding]; other site 316274013358 homohexameric interface [polypeptide binding]; other site 316274013359 elongation factor Ts; Reviewed; Region: tsf; PRK12332 316274013360 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 316274013361 Elongation factor TS; Region: EF_TS; pfam00889 316274013362 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 316274013363 rRNA interaction site [nucleotide binding]; other site 316274013364 S8 interaction site; other site 316274013365 putative laminin-1 binding site; other site 316274013366 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 316274013367 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274013368 dimer interface [polypeptide binding]; other site 316274013369 ssDNA binding site [nucleotide binding]; other site 316274013370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274013371 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 316274013372 excinuclease ABC subunit B; Provisional; Region: PRK05298 316274013373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274013374 ATP binding site [chemical binding]; other site 316274013375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274013376 nucleotide binding region [chemical binding]; other site 316274013377 ATP-binding site [chemical binding]; other site 316274013378 Ultra-violet resistance protein B; Region: UvrB; pfam12344 316274013379 UvrB/uvrC motif; Region: UVR; pfam02151 316274013380 helicase 45; Provisional; Region: PTZ00424 316274013381 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 316274013382 ATP binding site [chemical binding]; other site 316274013383 Mg++ binding site [ion binding]; other site 316274013384 motif III; other site 316274013385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274013386 nucleotide binding region [chemical binding]; other site 316274013387 ATP-binding site [chemical binding]; other site 316274013388 DbpA RNA binding domain; Region: DbpA; pfam03880 316274013389 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 316274013390 active site 316274013391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274013392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013393 ATP binding site [chemical binding]; other site 316274013394 Mg2+ binding site [ion binding]; other site 316274013395 G-X-G motif; other site 316274013396 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 316274013397 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316274013398 Clp amino terminal domain; Region: Clp_N; pfam02861 316274013399 Clp amino terminal domain; Region: Clp_N; pfam02861 316274013400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274013401 Walker A motif; other site 316274013402 ATP binding site [chemical binding]; other site 316274013403 Walker B motif; other site 316274013404 arginine finger; other site 316274013405 Protein of unknown function (DUF1167); Region: DUF1167; pfam06657 316274013406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274013407 Walker A motif; other site 316274013408 ATP binding site [chemical binding]; other site 316274013409 Walker B motif; other site 316274013410 arginine finger; other site 316274013411 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274013412 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 316274013413 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 316274013414 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 316274013415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013416 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 316274013417 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274013418 phosphopeptide binding site; other site 316274013419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274013420 phosphopeptide binding site; other site 316274013421 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 316274013422 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 316274013423 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 316274013424 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 316274013425 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 316274013426 4Fe-4S binding domain; Region: Fer4; cl02805 316274013427 NADH dehydrogenase; Region: NADHdh; cl00469 316274013428 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 316274013429 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 316274013430 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 316274013431 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316274013432 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274013433 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 316274013434 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274013435 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274013436 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274013437 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274013438 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316274013439 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 316274013440 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013441 active site 316274013442 ATP binding site [chemical binding]; other site 316274013443 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274013444 substrate binding site [chemical binding]; other site 316274013445 activation loop (A-loop); other site 316274013446 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 316274013447 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 316274013448 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 316274013449 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 316274013450 active site 316274013451 PspC domain; Region: PspC; cl00864 316274013452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274013453 sodium/calcium exchanger 1; Region: caca; TIGR00845 316274013454 Calx-beta domain; Region: Calx-beta; cl02522 316274013455 Calx-beta domain; Region: Calx-beta; cl02522 316274013456 Calx-beta domain; Region: Calx-beta; cl02522 316274013457 Calx-beta domain; Region: Calx-beta; cl02522 316274013458 Calx-beta domain; Region: Calx-beta; cl02522 316274013459 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316274013460 MPN+ (JAMM) motif; other site 316274013461 Zinc-binding site [ion binding]; other site 316274013462 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 316274013463 putative active site [active] 316274013464 putative catalytic site [active] 316274013465 putative Mg binding site IVb [ion binding]; other site 316274013466 putative phosphate binding site [ion binding]; other site 316274013467 putative DNA binding site [nucleotide binding]; other site 316274013468 putative Mg binding site IVa [ion binding]; other site 316274013469 potassium uptake protein; Region: kup; TIGR00794 316274013470 K+ potassium transporter; Region: K_trans; cl01227 316274013471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013472 plasmid segregation protein ParM; Provisional; Region: PRK13917 316274013473 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274013474 DNA binding residues [nucleotide binding] 316274013475 drug binding residues [chemical binding]; other site 316274013476 dimer interface [polypeptide binding]; other site 316274013477 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 316274013478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274013479 Protein of unknown function (DUF433); Region: DUF433; cl01030 316274013480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 316274013481 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 316274013482 Integrase core domain; Region: rve; cl01316 316274013483 putative transposase OrfB; Reviewed; Region: PHA02517 316274013484 Integrase core domain; Region: rve; cl01316 316274013485 CARDB; Region: CARDB; pfam07705 316274013486 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 316274013487 Cupin domain; Region: Cupin_2; cl09118 316274013488 glycosyltransferase, MGT family; Region: MGT; TIGR01426 316274013489 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274013490 active site 316274013491 TDP-binding site; other site 316274013492 acceptor substrate-binding pocket; other site 316274013493 homodimer interface [polypeptide binding]; other site 316274013494 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274013495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013496 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274013497 Transposase domain (DUF772); Region: DUF772; cl12084 316274013498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 316274013499 Transposase; Region: DDE_Tnp_ISL3; pfam01610 316274013500 MULE transposase domain; Region: MULE; pfam10551 316274013501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274013502 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274013503 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 316274013504 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274013505 active site 316274013506 ATP binding site [chemical binding]; other site 316274013507 Putative transposase; Region: Y2_Tnp; pfam04986 316274013508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013509 DNA binding site [nucleotide binding] 316274013510 Int/Topo IB signature motif; other site 316274013511 active site 316274013512 Putative cyclase; Region: Cyclase; cl00814 316274013513 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 316274013514 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013515 Integrase core domain; Region: rve; cl01316 316274013516 putative transposase OrfB; Reviewed; Region: PHA02517 316274013517 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 316274013518 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 316274013519 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316274013520 oligomeric interface; other site 316274013521 putative active site [active] 316274013522 homodimer interface [polypeptide binding]; other site 316274013523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274013525 DNA binding residues [nucleotide binding] 316274013526 Integrase core domain; Region: rve; cl01316 316274013527 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274013528 active site 316274013529 catalytic site [active] 316274013530 Apolipoprotein M (ApoM); Region: ApoM; pfam11032 316274013531 Domain of unknown function DUF11; Region: DUF11; cl03172 316274013532 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274013533 Domain of unknown function DUF11; Region: DUF11; cl03172 316274013534 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013535 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 316274013536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274013537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274013538 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274013539 substrate binding pocket [chemical binding]; other site 316274013540 substrate-Mg2+ binding site; other site 316274013541 aspartate-rich region 1; other site 316274013542 aspartate-rich region 2; other site 316274013543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274013545 DNA binding residues [nucleotide binding] 316274013546 dimerization interface [polypeptide binding]; other site 316274013547 PHAX RNA-binding domain; Region: RNA_GG_bind; pfam10258 316274013548 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274013549 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274013550 CRISPR-associated protein, TIGR03985 family; Region: TIGR03985 316274013551 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 316274013552 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 316274013553 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 316274013554 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 316274013555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274013556 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 316274013557 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 316274013558 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274013559 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274013560 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 316274013561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274013562 DNA binding residues [nucleotide binding] 316274013563 dimerization interface [polypeptide binding]; other site 316274013564 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274013565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274013566 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 316274013567 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 316274013568 active site 316274013569 substrate binding site [chemical binding]; other site 316274013570 trimer interface [polypeptide binding]; other site 316274013571 CoA binding site [chemical binding]; other site 316274013572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013573 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 316274013574 Active site [active] 316274013575 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013577 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013578 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 316274013579 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; cl07328 316274013580 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274013581 Probable Catalytic site [active] 316274013582 metal binding site [ion binding]; metal-binding site 316274013583 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274013584 Ligand binding site [chemical binding]; other site 316274013585 Putative Catalytic site [active] 316274013586 DXD motif; other site 316274013587 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 316274013588 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274013589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274013590 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274013591 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 316274013592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013593 AAA-like domain; Region: AAA_10; pfam12846 316274013594 Walker A motif; other site 316274013595 ATP binding site [chemical binding]; other site 316274013596 Walker B motif; other site 316274013597 AAA-like domain; Region: AAA_10; pfam12846 316274013598 Domain of unknown function DUF87; Region: DUF87; pfam01935 316274013599 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 316274013600 NlpC/P60 family; Region: NLPC_P60; cl11438 316274013601 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274013602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013603 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274013604 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274013605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013606 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274013607 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274013608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013609 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274013610 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 316274013611 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274013612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274013613 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274013614 MULE transposase domain; Region: MULE; pfam10551 316274013615 CHAT domain; Region: CHAT; cl02083 316274013616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013617 Walker B motif; other site 316274013618 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274013619 metal ion-dependent adhesion site (MIDAS); other site 316274013620 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274013621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274013622 active site 316274013623 ATP binding site [chemical binding]; other site 316274013624 substrate binding site [chemical binding]; other site 316274013625 activation loop (A-loop); other site 316274013626 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274013627 catalytic residues [active] 316274013628 catalytic nucleophile [active] 316274013629 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274013630 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274013631 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274013632 Synaptic Site I dimer interface [polypeptide binding]; other site 316274013633 DNA binding site [nucleotide binding] 316274013634 CHAT domain; Region: CHAT; cl02083 316274013635 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274013636 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274013637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013638 binding surface 316274013639 TPR motif; other site 316274013640 Archaeal ATPase; Region: Arch_ATPase; pfam01637 316274013641 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274013642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013643 binding surface 316274013644 TPR motif; other site 316274013645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013646 binding surface 316274013647 TPR motif; other site 316274013648 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274013649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013650 binding surface 316274013651 TPR motif; other site 316274013652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013653 binding surface 316274013654 TPR motif; other site 316274013655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013656 binding surface 316274013657 TPR motif; other site 316274013658 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 316274013659 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274013660 putative active site [active] 316274013661 putative NTP binding site [chemical binding]; other site 316274013662 putative nucleic acid binding site [nucleotide binding]; other site 316274013663 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 316274013664 CHAT domain; Region: CHAT; cl02083 316274013665 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274013666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013667 binding surface 316274013668 TPR motif; other site 316274013669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013670 binding surface 316274013671 TPR motif; other site 316274013672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013673 TPR motif; other site 316274013674 binding surface 316274013675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 316274013676 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274013677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013678 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 316274013679 Putative transposase; Region: Y2_Tnp; pfam04986 316274013680 integron integrase; Region: integrase_gron; TIGR02249 316274013681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013682 DNA binding site [nucleotide binding] 316274013683 Int/Topo IB signature motif; other site 316274013684 active site 316274013685 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 316274013686 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274013687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274013688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013689 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 316274013690 DNA binding site [nucleotide binding] 316274013691 Int/Topo IB signature motif; other site 316274013692 active site 316274013693 catalytic residues [active] 316274013694 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 316274013695 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 316274013696 catalytic residues [active] 316274013697 XisI protein; Region: XisI; pfam08869 316274013698 XisH protein; Region: XisH; pfam08814 316274013699 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316274013700 oligomeric interface; other site 316274013701 putative active site [active] 316274013702 homodimer interface [polypeptide binding]; other site 316274013703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274013704 non-specific DNA binding site [nucleotide binding]; other site 316274013705 salt bridge; other site 316274013706 sequence-specific DNA binding site [nucleotide binding]; other site 316274013707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013708 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 316274013709 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274013710 active site 316274013711 catalytic triad [active] 316274013712 Cupin domain; Region: Cupin_2; cl09118 316274013713 CCC1-related family of proteins; Region: CCC1_like; cl00278 316274013714 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 316274013715 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 316274013716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274013717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 316274013718 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 316274013719 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 316274013720 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316274013721 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274013722 catalytic residues [active] 316274013723 catalytic nucleophile [active] 316274013724 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274013725 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274013726 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274013727 Synaptic Site I dimer interface [polypeptide binding]; other site 316274013728 DNA binding site [nucleotide binding] 316274013729 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 316274013730 DNA-binding interface [nucleotide binding]; DNA binding site 316274013731 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 316274013732 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013733 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013734 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274013735 amidase catalytic site [active] 316274013736 Zn binding residues [ion binding]; other site 316274013737 substrate binding site [chemical binding]; other site 316274013738 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274013739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013740 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013742 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274013743 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 316274013744 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013745 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274013747 active site 316274013748 phosphorylation site [posttranslational modification] 316274013749 intermolecular recognition site; other site 316274013750 dimerization interface [polypeptide binding]; other site 316274013751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013752 GAF domain; Region: GAF; cl00853 316274013753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013754 PAS fold; Region: PAS_3; pfam08447 316274013755 putative active site [active] 316274013756 heme pocket [chemical binding]; other site 316274013757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013758 putative active site [active] 316274013759 PAS fold; Region: PAS_3; pfam08447 316274013760 heme pocket [chemical binding]; other site 316274013761 PAS domain S-box; Region: sensory_box; TIGR00229 316274013762 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 316274013765 active site 316274013766 phosphorylation site [posttranslational modification] 316274013767 intermolecular recognition site; other site 316274013768 dimerization interface [polypeptide binding]; other site 316274013769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274013770 DNA binding residues [nucleotide binding] 316274013771 dimerization interface [polypeptide binding]; other site 316274013772 PAS fold; Region: PAS_4; pfam08448 316274013773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013774 putative active site [active] 316274013775 heme pocket [chemical binding]; other site 316274013776 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013777 GAF domain; Region: GAF; cl00853 316274013778 Histidine kinase; Region: HisKA_3; pfam07730 316274013779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013780 ATP binding site [chemical binding]; other site 316274013781 Mg2+ binding site [ion binding]; other site 316274013782 G-X-G motif; other site 316274013783 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274013784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316274013785 short chain dehydrogenase; Provisional; Region: PRK06197 316274013786 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 316274013787 putative NAD(P) binding site [chemical binding]; other site 316274013788 active site 316274013789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274013790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274013791 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274013792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274013793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274013795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274013796 active site 316274013797 Protein of unknown function DUF262; Region: DUF262; cl14890 316274013798 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 316274013799 UvrD/REP helicase; Region: UvrD-helicase; cl14126 316274013800 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 316274013801 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 316274013802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 316274013803 ATP binding site [chemical binding]; other site 316274013804 Walker A motif; other site 316274013805 Walker B motif; other site 316274013806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274013807 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274013808 DNA binding site [nucleotide binding] 316274013809 Int/Topo IB signature motif; other site 316274013810 active site 316274013811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 316274013813 DNA binding residues [nucleotide binding] 316274013814 Integrase core domain; Region: rve; cl01316 316274013815 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 316274013816 SWIM zinc finger; Region: SWIM; cl11618 316274013817 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 316274013818 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 316274013819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274013820 ATP binding site [chemical binding]; other site 316274013821 putative Mg++ binding site [ion binding]; other site 316274013822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274013823 nucleotide binding region [chemical binding]; other site 316274013824 ATP-binding site [chemical binding]; other site 316274013825 legume lectins; Region: lectin_L-type; cd01951 316274013826 homotetramer interaction site [polypeptide binding]; other site 316274013827 homodimer interaction site [polypeptide binding]; other site 316274013828 carbohydrate binding site [chemical binding]; other site 316274013829 metal binding site [ion binding]; metal-binding site 316274013830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 316274013831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274013833 AAA-like domain; Region: AAA_10; pfam12846 316274013834 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 316274013835 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 316274013836 AAA-like domain; Region: AAA_10; pfam12846 316274013837 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274013838 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274013839 putative active site [active] 316274013840 putative NTP binding site [chemical binding]; other site 316274013841 putative nucleic acid binding site [nucleotide binding]; other site 316274013842 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274013843 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 316274013844 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 316274013845 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274013846 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274013847 dimer interface [polypeptide binding]; other site 316274013848 ssDNA binding site [nucleotide binding]; other site 316274013849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274013850 putative transposase OrfB; Reviewed; Region: PHA02517 316274013851 Integrase core domain; Region: rve; cl01316 316274013852 Cytochrome P450; Region: p450; cl12078 316274013853 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274013854 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274013855 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274013856 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 316274013857 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 316274013858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274013859 Beta-Casp domain; Region: Beta-Casp; pfam10996 316274013860 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 316274013861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013862 binding surface 316274013863 TPR motif; other site 316274013864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013865 binding surface 316274013866 TPR motif; other site 316274013867 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274013868 MULE transposase domain; Region: MULE; pfam10551 316274013869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013870 binding surface 316274013871 CHAT domain; Region: CHAT; cl02083 316274013872 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274013873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013874 binding surface 316274013875 TPR motif; other site 316274013876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013877 binding surface 316274013878 TPR motif; other site 316274013879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013880 binding surface 316274013881 TPR motif; other site 316274013882 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 316274013883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013884 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013885 ABC transporter signature motif; other site 316274013886 Walker B; other site 316274013887 D-loop; other site 316274013888 H-loop/switch region; other site 316274013889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 316274013890 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 316274013891 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274013892 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 316274013893 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316274013894 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 316274013895 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 316274013896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274013897 ATP binding site [chemical binding]; other site 316274013898 putative Mg++ binding site [ion binding]; other site 316274013899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 316274013900 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 316274013901 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 316274013902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013903 binding surface 316274013904 TPR motif; other site 316274013905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 316274013906 binding surface 316274013907 TPR motif; other site 316274013908 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274013909 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274013910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274013911 non-specific DNA binding site [nucleotide binding]; other site 316274013912 salt bridge; other site 316274013913 sequence-specific DNA binding site [nucleotide binding]; other site 316274013914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 316274013915 potassium and/or sodium efflux P-type ATPase, fungal-type; Region: ATPase-IID_K-Na; TIGR01523 316274013916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697