-- dump date 20140619_114952 -- class Genbank::misc_feature -- table misc_feature_note -- id note 316274000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 316274000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 316274000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000004 Walker A motif; other site 316274000005 ATP binding site [chemical binding]; other site 316274000006 Walker B motif; other site 316274000007 arginine finger; other site 316274000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 316274000009 DnaA box-binding interface [nucleotide binding]; other site 316274000010 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 316274000011 M28 Zn-Peptidases; Region: M28_like_6; cd08656 316274000012 Peptidase family M28; Region: Peptidase_M28; pfam04389 316274000013 metal binding site [ion binding]; metal-binding site 316274000014 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 316274000015 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 316274000016 metal binding site [ion binding]; metal-binding site 316274000017 dimer interface [polypeptide binding]; other site 316274000018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274000019 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274000020 binding surface 316274000021 TPR motif; other site 316274000022 Colicin V production protein; Region: Colicin_V; pfam02674 316274000023 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 316274000024 ADP-ribose binding site [chemical binding]; other site 316274000025 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274000026 CoenzymeA binding site [chemical binding]; other site 316274000027 subunit interaction site [polypeptide binding]; other site 316274000028 PHB binding site; other site 316274000029 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 316274000030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274000031 motif II; other site 316274000032 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000033 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000034 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000035 diaminopimelate decarboxylase; Region: lysA; TIGR01048 316274000036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 316274000037 active site 316274000038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274000039 substrate binding site [chemical binding]; other site 316274000040 catalytic residues [active] 316274000041 dimer interface [polypeptide binding]; other site 316274000042 DNA primase; Validated; Region: dnaG; PRK05667 316274000043 CHC2 zinc finger; Region: zf-CHC2; pfam01807 316274000044 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 316274000045 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 316274000046 interdomain interaction site; other site 316274000047 active site 316274000048 metal binding site [ion binding]; metal-binding site 316274000049 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 316274000050 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274000051 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 316274000052 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274000053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274000054 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274000055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274000056 DNA binding residues [nucleotide binding] 316274000057 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 316274000058 Protein of unknown function (DUF418); Region: DUF418; pfam04235 316274000059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274000060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274000061 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 316274000062 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 316274000063 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 316274000064 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 316274000065 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 316274000066 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 316274000067 malonyl-CoA binding site [chemical binding]; other site 316274000068 dimer interface [polypeptide binding]; other site 316274000069 active site 316274000070 product binding site; other site 316274000071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274000072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000073 active site 316274000074 ATP binding site [chemical binding]; other site 316274000075 substrate binding site [chemical binding]; other site 316274000076 activation loop (A-loop); other site 316274000077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000080 active site 316274000081 ATP binding site [chemical binding]; other site 316274000082 substrate binding site [chemical binding]; other site 316274000083 activation loop (A-loop); other site 316274000084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316274000085 active site 316274000086 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274000087 catalytic residues [active] 316274000088 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274000089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274000090 catalytic residues [active] 316274000091 MbtH-like protein; Region: MbtH; cl01279 316274000092 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316274000093 Clp amino terminal domain; Region: Clp_N; pfam02861 316274000094 Clp amino terminal domain; Region: Clp_N; pfam02861 316274000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000096 Walker A motif; other site 316274000097 ATP binding site [chemical binding]; other site 316274000098 Walker B motif; other site 316274000099 arginine finger; other site 316274000100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000101 Walker A motif; other site 316274000102 ATP binding site [chemical binding]; other site 316274000103 Walker B motif; other site 316274000104 arginine finger; other site 316274000105 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274000106 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 316274000107 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316274000108 HSP70 interaction site [polypeptide binding]; other site 316274000109 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316274000110 substrate binding site [polypeptide binding]; other site 316274000111 dimer interface [polypeptide binding]; other site 316274000112 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 316274000113 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 316274000114 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 316274000115 tetramer interface [polypeptide binding]; other site 316274000116 heme binding pocket [chemical binding]; other site 316274000117 NADPH binding site [chemical binding]; other site 316274000118 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 316274000119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316274000120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316274000121 dimerization interface [polypeptide binding]; other site 316274000122 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 316274000123 FOG: CBS domain [General function prediction only]; Region: COG0517 316274000124 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 316274000125 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274000126 putative active site [active] 316274000127 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 316274000128 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 316274000129 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316274000130 dimer interface [polypeptide binding]; other site 316274000131 PYR/PP interface [polypeptide binding]; other site 316274000132 TPP binding site [chemical binding]; other site 316274000133 substrate binding site [chemical binding]; other site 316274000134 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 316274000135 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 316274000136 TPP-binding site [chemical binding]; other site 316274000137 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 316274000138 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316274000139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274000140 catalytic core [active] 316274000141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000142 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274000143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274000144 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274000145 cyclase homology domain; Region: CHD; cd07302 316274000146 nucleotidyl binding site; other site 316274000147 metal binding site [ion binding]; metal-binding site 316274000148 dimer interface [polypeptide binding]; other site 316274000149 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316274000150 cyclase homology domain; Region: CHD; cd07302 316274000151 nucleotidyl binding site; other site 316274000152 metal binding site [ion binding]; metal-binding site 316274000153 dimer interface [polypeptide binding]; other site 316274000154 AAA ATPase domain; Region: AAA_16; pfam13191 316274000155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000157 TPR motif; other site 316274000158 binding surface 316274000159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000162 binding surface 316274000163 TPR motif; other site 316274000164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000166 binding surface 316274000167 TPR motif; other site 316274000168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000169 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274000170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000171 Walker A motif; other site 316274000172 ATP binding site [chemical binding]; other site 316274000173 Walker B motif; other site 316274000174 arginine finger; other site 316274000175 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 316274000176 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274000177 metal ion-dependent adhesion site (MIDAS); other site 316274000178 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 316274000179 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274000180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000181 ligand binding site [chemical binding]; other site 316274000182 flexible hinge region; other site 316274000183 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 316274000184 RNA ligase; Region: RNA_ligase; pfam09414 316274000185 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 316274000186 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274000187 aspartate aminotransferase; Provisional; Region: PRK05957 316274000188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274000189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000190 homodimer interface [polypeptide binding]; other site 316274000191 catalytic residue [active] 316274000192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274000193 active site 316274000194 phosphorylation site [posttranslational modification] 316274000195 intermolecular recognition site; other site 316274000196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274000197 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 316274000198 phosphorylation site [posttranslational modification] 316274000199 dimer interface [polypeptide binding]; other site 316274000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000201 ATP binding site [chemical binding]; other site 316274000202 Mg2+ binding site [ion binding]; other site 316274000203 G-X-G motif; other site 316274000204 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 316274000205 PGAP1-like protein; Region: PGAP1; pfam07819 316274000206 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 316274000207 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 316274000208 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 316274000209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274000210 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274000211 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 316274000212 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274000213 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274000214 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 316274000215 IMP binding site; other site 316274000216 dimer interface [polypeptide binding]; other site 316274000217 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 316274000218 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 316274000219 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 316274000220 GIY-YIG motif/motif A; other site 316274000221 active site 316274000222 catalytic site [active] 316274000223 putative DNA binding site [nucleotide binding]; other site 316274000224 metal binding site [ion binding]; metal-binding site 316274000225 UvrB/uvrC motif; Region: UVR; pfam02151 316274000226 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 316274000227 Helix-hairpin-helix motif; Region: HHH; pfam00633 316274000228 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 316274000229 O-Antigen ligase; Region: Wzy_C; pfam04932 316274000230 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316274000231 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 316274000232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274000233 S-adenosylmethionine binding site [chemical binding]; other site 316274000234 Protein of unknown function (DUF983); Region: DUF983; cl02211 316274000235 DNA polymerase I; Provisional; Region: PRK05755 316274000236 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316274000237 active site 316274000238 metal binding site 1 [ion binding]; metal-binding site 316274000239 putative 5' ssDNA interaction site; other site 316274000240 metal binding site 3; metal-binding site 316274000241 metal binding site 2 [ion binding]; metal-binding site 316274000242 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316274000243 putative DNA binding site [nucleotide binding]; other site 316274000244 putative metal binding site [ion binding]; other site 316274000245 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 316274000246 active site 316274000247 catalytic site [active] 316274000248 substrate binding site [chemical binding]; other site 316274000249 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 316274000250 active site 316274000251 DNA binding site [nucleotide binding] 316274000252 catalytic site [active] 316274000253 Response regulator receiver domain; Region: Response_reg; pfam00072 316274000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274000255 active site 316274000256 phosphorylation site [posttranslational modification] 316274000257 intermolecular recognition site; other site 316274000258 dimerization interface [polypeptide binding]; other site 316274000259 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274000260 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274000261 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274000262 GAF domain; Region: GAF; cl17456 316274000263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274000264 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 316274000265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000266 ATP binding site [chemical binding]; other site 316274000267 G-X-G motif; other site 316274000268 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 316274000269 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 316274000270 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 316274000271 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274000272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000273 Walker A motif; other site 316274000274 ATP binding site [chemical binding]; other site 316274000275 Walker B motif; other site 316274000276 arginine finger; other site 316274000277 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274000278 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274000279 phosphodiesterase YaeI; Provisional; Region: PRK11340 316274000280 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274000281 putative active site [active] 316274000282 putative metal binding site [ion binding]; other site 316274000283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000284 S-adenosylmethionine binding site [chemical binding]; other site 316274000285 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 316274000286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 316274000287 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 316274000288 putative active site [active] 316274000289 putative metal binding site [ion binding]; other site 316274000290 HEAT repeats; Region: HEAT_2; pfam13646 316274000291 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 316274000292 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 316274000293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 316274000294 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 316274000295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274000296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274000297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274000298 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 316274000299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274000300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000301 Walker A motif; other site 316274000302 ATP binding site [chemical binding]; other site 316274000303 Walker B motif; other site 316274000304 arginine finger; other site 316274000305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000306 binding surface 316274000307 TPR motif; other site 316274000308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000309 binding surface 316274000310 TPR motif; other site 316274000311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000312 TPR repeat; Region: TPR_11; pfam13414 316274000313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000314 binding surface 316274000315 TPR motif; other site 316274000316 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274000317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000318 TPR motif; other site 316274000319 binding surface 316274000320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000321 binding surface 316274000322 TPR motif; other site 316274000323 TPR repeat; Region: TPR_11; pfam13414 316274000324 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316274000325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274000326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274000327 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 316274000328 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 316274000329 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 316274000330 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 316274000331 active site 316274000332 metal binding site [ion binding]; metal-binding site 316274000333 transcriptional regulator FimZ; Provisional; Region: PRK09935 316274000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274000335 active site 316274000336 phosphorylation site [posttranslational modification] 316274000337 intermolecular recognition site; other site 316274000338 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 316274000339 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 316274000340 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 316274000341 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 316274000342 Ca binding site [ion binding]; other site 316274000343 active site 316274000344 catalytic site [active] 316274000345 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 316274000346 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 316274000347 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 316274000348 GatB domain; Region: GatB_Yqey; smart00845 316274000349 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 316274000350 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 316274000351 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 316274000352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274000353 ATP binding site [chemical binding]; other site 316274000354 putative Mg++ binding site [ion binding]; other site 316274000355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274000356 nucleotide binding region [chemical binding]; other site 316274000357 ATP-binding site [chemical binding]; other site 316274000358 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 316274000359 AAA ATPase domain; Region: AAA_16; pfam13191 316274000360 NACHT domain; Region: NACHT; pfam05729 316274000361 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000362 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 316274000363 structural tetrad; other site 316274000364 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000365 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 316274000366 structural tetrad; other site 316274000367 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274000368 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316274000369 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 316274000370 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 316274000371 Cytochrome c; Region: Cytochrom_C; pfam00034 316274000372 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 316274000373 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 316274000374 D-pathway; other site 316274000375 Putative ubiquinol binding site [chemical binding]; other site 316274000376 Low-spin heme (heme b) binding site [chemical binding]; other site 316274000377 Putative water exit pathway; other site 316274000378 Binuclear center (heme o3/CuB) [ion binding]; other site 316274000379 K-pathway; other site 316274000380 Putative proton exit pathway; other site 316274000381 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 316274000382 Subunit I/III interface [polypeptide binding]; other site 316274000383 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 316274000384 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 316274000385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274000386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274000388 Coenzyme A binding pocket [chemical binding]; other site 316274000389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274000390 dimerization interface [polypeptide binding]; other site 316274000391 putative DNA binding site [nucleotide binding]; other site 316274000392 putative Zn2+ binding site [ion binding]; other site 316274000393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274000394 dimerization interface [polypeptide binding]; other site 316274000395 putative DNA binding site [nucleotide binding]; other site 316274000396 putative Zn2+ binding site [ion binding]; other site 316274000397 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 316274000398 DNA methylase; Region: N6_N4_Mtase; pfam01555 316274000399 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000401 S-adenosylmethionine binding site [chemical binding]; other site 316274000402 DNA methylase; Region: N6_N4_Mtase; cl17433 316274000403 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 316274000404 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 316274000405 active site 316274000406 Zn binding site [ion binding]; other site 316274000407 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274000408 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 316274000409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274000410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000411 homodimer interface [polypeptide binding]; other site 316274000412 catalytic residue [active] 316274000413 elongation factor Tu; Reviewed; Region: PRK00049 316274000414 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 316274000415 G1 box; other site 316274000416 GEF interaction site [polypeptide binding]; other site 316274000417 GTP/Mg2+ binding site [chemical binding]; other site 316274000418 Switch I region; other site 316274000419 G2 box; other site 316274000420 G3 box; other site 316274000421 Switch II region; other site 316274000422 G4 box; other site 316274000423 G5 box; other site 316274000424 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316274000425 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 316274000426 Antibiotic Binding Site [chemical binding]; other site 316274000427 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 316274000428 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 316274000429 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 316274000430 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 316274000431 putative homodimer interface [polypeptide binding]; other site 316274000432 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 316274000433 heterodimer interface [polypeptide binding]; other site 316274000434 homodimer interface [polypeptide binding]; other site 316274000435 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 316274000436 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 316274000437 23S rRNA interface [nucleotide binding]; other site 316274000438 L7/L12 interface [polypeptide binding]; other site 316274000439 putative thiostrepton binding site; other site 316274000440 L25 interface [polypeptide binding]; other site 316274000441 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 316274000442 mRNA/rRNA interface [nucleotide binding]; other site 316274000443 Amidinotransferase; Region: Amidinotransf; pfam02274 316274000444 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 316274000445 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 316274000446 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 316274000447 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274000448 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 316274000449 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 316274000450 active site 316274000451 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316274000452 active site 316274000453 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 316274000454 homodecamer interface [polypeptide binding]; other site 316274000455 GTP cyclohydrolase I; Provisional; Region: PLN03044 316274000456 active site 316274000457 putative catalytic site residues [active] 316274000458 zinc binding site [ion binding]; other site 316274000459 GTP-CH-I/GFRP interaction surface; other site 316274000460 short chain dehydrogenase; Provisional; Region: PRK08219 316274000461 classical (c) SDRs; Region: SDR_c; cd05233 316274000462 NAD(P) binding site [chemical binding]; other site 316274000463 active site 316274000464 tartrate dehydrogenase; Provisional; Region: PRK08194 316274000465 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274000466 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 316274000467 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 316274000468 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274000469 putative active site [active] 316274000470 putative NTP binding site [chemical binding]; other site 316274000471 putative nucleic acid binding site [nucleotide binding]; other site 316274000472 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274000473 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274000474 active site 316274000475 AAA ATPase domain; Region: AAA_16; pfam13191 316274000476 NB-ARC domain; Region: NB-ARC; pfam00931 316274000477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000478 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000479 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274000480 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000481 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274000482 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274000483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000486 binding surface 316274000487 TPR motif; other site 316274000488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000489 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 316274000490 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 316274000491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274000492 inhibitor-cofactor binding pocket; inhibition site 316274000493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000494 catalytic residue [active] 316274000495 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 316274000496 23S rRNA interface [nucleotide binding]; other site 316274000497 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 316274000498 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 316274000499 core dimer interface [polypeptide binding]; other site 316274000500 peripheral dimer interface [polypeptide binding]; other site 316274000501 L10 interface [polypeptide binding]; other site 316274000502 L11 interface [polypeptide binding]; other site 316274000503 putative EF-Tu interaction site [polypeptide binding]; other site 316274000504 putative EF-G interaction site [polypeptide binding]; other site 316274000505 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 316274000506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274000507 ATP binding site [chemical binding]; other site 316274000508 substrate binding site [chemical binding]; other site 316274000509 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316274000510 homotrimer interaction site [polypeptide binding]; other site 316274000511 putative active site [active] 316274000512 hypothetical protein; Reviewed; Region: PRK12497 316274000513 enolase; Provisional; Region: eno; PRK00077 316274000514 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 316274000515 dimer interface [polypeptide binding]; other site 316274000516 metal binding site [ion binding]; metal-binding site 316274000517 substrate binding pocket [chemical binding]; other site 316274000518 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 316274000519 nucleotide binding site [chemical binding]; other site 316274000520 substrate binding site [chemical binding]; other site 316274000521 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274000522 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 316274000523 ATP binding site [chemical binding]; other site 316274000524 substrate binding site [chemical binding]; other site 316274000525 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274000526 nudix motif; other site 316274000527 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316274000528 HNH endonuclease; Region: HNH_2; pfam13391 316274000529 active site 316274000530 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 316274000531 LexA repressor; Validated; Region: PRK00215 316274000532 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 316274000533 Catalytic site [active] 316274000534 putative chaperone; Provisional; Region: PRK11678 316274000535 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 316274000536 nucleotide binding site [chemical binding]; other site 316274000537 putative NEF/HSP70 interaction site [polypeptide binding]; other site 316274000538 SBD interface [polypeptide binding]; other site 316274000539 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 316274000540 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 316274000541 active site 316274000542 Zn binding site [ion binding]; other site 316274000543 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 316274000544 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 316274000545 putative active site [active] 316274000546 oxyanion strand; other site 316274000547 catalytic triad [active] 316274000548 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 316274000549 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 316274000550 catalytic residues [active] 316274000551 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274000552 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 316274000553 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 316274000554 substrate binding site [chemical binding]; other site 316274000555 glutamase interaction surface [polypeptide binding]; other site 316274000556 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 316274000557 MoaE interaction surface [polypeptide binding]; other site 316274000558 MoeB interaction surface [polypeptide binding]; other site 316274000559 thiocarboxylated glycine; other site 316274000560 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 316274000561 MoaE homodimer interface [polypeptide binding]; other site 316274000562 MoaD interaction [polypeptide binding]; other site 316274000563 active site residues [active] 316274000564 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 316274000565 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274000566 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316274000567 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274000568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274000569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274000570 DNA binding residues [nucleotide binding] 316274000571 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 316274000572 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 316274000573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274000574 active site 316274000575 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274000576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000577 S-adenosylmethionine binding site [chemical binding]; other site 316274000578 Protein of unknown function (DUF433); Region: DUF433; cl01030 316274000579 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274000580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274000581 motif II; other site 316274000582 Ferredoxin [Energy production and conversion]; Region: COG1146 316274000583 4Fe-4S binding domain; Region: Fer4; cl02805 316274000584 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274000585 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316274000586 catalytic site [active] 316274000587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274000588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000589 ligand binding site [chemical binding]; other site 316274000590 flexible hinge region; other site 316274000591 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 316274000592 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 316274000593 catalytic residue [active] 316274000594 putative FPP diphosphate binding site; other site 316274000595 putative FPP binding hydrophobic cleft; other site 316274000596 dimer interface [polypeptide binding]; other site 316274000597 putative IPP diphosphate binding site; other site 316274000598 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316274000599 phage shock protein A; Region: phageshock_pspA; TIGR02977 316274000600 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 316274000601 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 316274000602 Double zinc ribbon; Region: DZR; pfam12773 316274000603 lipoyl synthase; Provisional; Region: PRK05481 316274000604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274000605 FeS/SAM binding site; other site 316274000606 DNA repair protein RadA; Provisional; Region: PRK11823 316274000607 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 316274000608 Walker A motif/ATP binding site; other site 316274000609 ATP binding site [chemical binding]; other site 316274000610 Walker B motif; other site 316274000611 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316274000612 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 316274000613 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 316274000614 putative active site [active] 316274000615 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 316274000616 putative active site [active] 316274000617 dimerization interface [polypeptide binding]; other site 316274000618 putative tRNAtyr binding site [nucleotide binding]; other site 316274000619 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274000620 Double zinc ribbon; Region: DZR; pfam12773 316274000621 MutL protein; Region: MutL; pfam13941 316274000622 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274000623 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274000624 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 316274000625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274000626 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 316274000627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000628 binding surface 316274000629 TPR motif; other site 316274000630 TPR repeat; Region: TPR_11; pfam13414 316274000631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000632 binding surface 316274000633 TPR motif; other site 316274000634 TPR repeat; Region: TPR_11; pfam13414 316274000635 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274000636 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316274000637 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 316274000638 DinB family; Region: DinB; cl17821 316274000639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274000640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274000641 Probable transposase; Region: OrfB_IS605; pfam01385 316274000642 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 316274000643 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 316274000644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274000645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274000646 Bacterial transcriptional repressor; Region: TetR; pfam13972 316274000647 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 316274000648 Response regulator receiver domain; Region: Response_reg; pfam00072 316274000649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274000650 active site 316274000651 phosphorylation site [posttranslational modification] 316274000652 intermolecular recognition site; other site 316274000653 dimerization interface [polypeptide binding]; other site 316274000654 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 316274000655 Sortase family; Region: Sortase; pfam04203 316274000656 active site 316274000657 catalytic site [active] 316274000658 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 316274000659 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 316274000660 phosphate binding site [ion binding]; other site 316274000661 putative substrate binding pocket [chemical binding]; other site 316274000662 dimer interface [polypeptide binding]; other site 316274000663 NurA domain; Region: NurA; pfam09376 316274000664 HAS barrel domain; Region: HAS-barrel; pfam09378 316274000665 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274000666 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274000667 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274000668 cyclase homology domain; Region: CHD; cd07302 316274000669 nucleotidyl binding site; other site 316274000670 metal binding site [ion binding]; metal-binding site 316274000671 dimer interface [polypeptide binding]; other site 316274000672 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274000673 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274000674 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 316274000675 Walker A/P-loop; other site 316274000676 ATP binding site [chemical binding]; other site 316274000677 Q-loop/lid; other site 316274000678 ABC transporter signature motif; other site 316274000679 Walker B; other site 316274000680 D-loop; other site 316274000681 H-loop/switch region; other site 316274000682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274000683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274000684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274000685 Walker A/P-loop; other site 316274000686 ATP binding site [chemical binding]; other site 316274000687 Q-loop/lid; other site 316274000688 ABC transporter signature motif; other site 316274000689 Walker B; other site 316274000690 D-loop; other site 316274000691 H-loop/switch region; other site 316274000692 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 316274000693 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 316274000694 active site 316274000695 HIGH motif; other site 316274000696 dimer interface [polypeptide binding]; other site 316274000697 KMSKS motif; other site 316274000698 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274000699 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 316274000700 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 316274000701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274000702 catalytic residue [active] 316274000703 Bacterial SH3 domain; Region: SH3_3; cl17532 316274000704 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 316274000705 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274000706 active site 316274000707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000708 S-adenosylmethionine binding site [chemical binding]; other site 316274000709 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 316274000710 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 316274000711 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 316274000712 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 316274000713 active site 316274000714 substrate binding site [chemical binding]; other site 316274000715 FMN binding site [chemical binding]; other site 316274000716 putative catalytic residues [active] 316274000717 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274000718 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316274000719 Walker A/P-loop; other site 316274000720 ATP binding site [chemical binding]; other site 316274000721 Q-loop/lid; other site 316274000722 ABC transporter signature motif; other site 316274000723 Walker B; other site 316274000724 D-loop; other site 316274000725 H-loop/switch region; other site 316274000726 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 316274000727 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316274000728 Walker A/P-loop; other site 316274000729 ATP binding site [chemical binding]; other site 316274000730 Q-loop/lid; other site 316274000731 ABC transporter signature motif; other site 316274000732 Walker B; other site 316274000733 D-loop; other site 316274000734 H-loop/switch region; other site 316274000735 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 316274000736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274000737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274000738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000739 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 316274000740 putative ADP-binding pocket [chemical binding]; other site 316274000741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000742 active site 316274000743 ATP binding site [chemical binding]; other site 316274000744 substrate binding site [chemical binding]; other site 316274000745 activation loop (A-loop); other site 316274000746 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274000747 active site 316274000748 ATP binding site [chemical binding]; other site 316274000749 substrate binding site [chemical binding]; other site 316274000750 activation loop (A-loop); other site 316274000751 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 316274000752 dimer interface [polypeptide binding]; other site 316274000753 active site 316274000754 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 316274000755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274000756 active site 316274000757 motif I; other site 316274000758 motif II; other site 316274000759 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 316274000760 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 316274000761 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 316274000762 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 316274000763 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 316274000764 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 316274000765 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316274000766 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 316274000767 G-loop; other site 316274000768 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316274000769 DNA binding site [nucleotide binding] 316274000770 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 316274000771 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 316274000772 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 316274000773 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 316274000774 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 316274000775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 316274000776 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 316274000777 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 316274000778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 316274000779 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 316274000780 RPB10 interaction site [polypeptide binding]; other site 316274000781 RPB1 interaction site [polypeptide binding]; other site 316274000782 RPB11 interaction site [polypeptide binding]; other site 316274000783 RPB3 interaction site [polypeptide binding]; other site 316274000784 RPB12 interaction site [polypeptide binding]; other site 316274000785 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 316274000786 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 316274000787 active site 316274000788 Riboflavin kinase; Region: Flavokinase; pfam01687 316274000789 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 316274000790 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274000791 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274000792 DNA binding residues [nucleotide binding] 316274000793 drug binding residues [chemical binding]; other site 316274000794 dimer interface [polypeptide binding]; other site 316274000795 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 316274000796 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274000797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274000798 Coenzyme A binding pocket [chemical binding]; other site 316274000799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274000800 metal ion-dependent adhesion site (MIDAS); other site 316274000801 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274000802 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274000803 metal ion-dependent adhesion site (MIDAS); other site 316274000804 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274000805 Filamin/ABP280 repeat; Region: Filamin; pfam00630 316274000806 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 316274000807 von Willebrand factor type A domain; Region: VWA_2; pfam13519 316274000808 YcxB-like protein; Region: YcxB; pfam14317 316274000809 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274000810 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274000811 Thioredoxin; Region: Thioredoxin_4; pfam13462 316274000812 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274000813 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274000814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274000815 Walker A motif; other site 316274000816 ATP binding site [chemical binding]; other site 316274000817 Walker B motif; other site 316274000818 arginine finger; other site 316274000819 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 316274000820 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316274000821 sulfate transport protein; Provisional; Region: cysT; CHL00187 316274000822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274000823 dimer interface [polypeptide binding]; other site 316274000824 conserved gate region; other site 316274000825 putative PBP binding loops; other site 316274000826 ABC-ATPase subunit interface; other site 316274000827 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316274000828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274000829 dimer interface [polypeptide binding]; other site 316274000830 conserved gate region; other site 316274000831 putative PBP binding loops; other site 316274000832 ABC-ATPase subunit interface; other site 316274000833 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316274000834 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 316274000835 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274000836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274000837 Walker A/P-loop; other site 316274000838 ATP binding site [chemical binding]; other site 316274000839 Q-loop/lid; other site 316274000840 ABC transporter signature motif; other site 316274000841 Walker B; other site 316274000842 D-loop; other site 316274000843 H-loop/switch region; other site 316274000844 TOBE domain; Region: TOBE_2; pfam08402 316274000845 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274000846 Ligand Binding Site [chemical binding]; other site 316274000847 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 316274000848 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316274000849 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 316274000850 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 316274000851 Formiminotransferase domain; Region: FTCD; pfam02971 316274000852 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 316274000853 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316274000854 active site 316274000855 NTP binding site [chemical binding]; other site 316274000856 metal binding triad [ion binding]; metal-binding site 316274000857 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316274000858 HD domain; Region: HD; pfam01966 316274000859 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 316274000860 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 316274000861 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 316274000862 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 316274000863 ADP binding site [chemical binding]; other site 316274000864 magnesium binding site [ion binding]; other site 316274000865 putative shikimate binding site; other site 316274000866 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 316274000867 active site 316274000868 dimer interface [polypeptide binding]; other site 316274000869 metal binding site [ion binding]; metal-binding site 316274000870 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 316274000871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274000872 S-adenosylmethionine binding site [chemical binding]; other site 316274000873 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 316274000874 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274000875 AAA ATPase domain; Region: AAA_16; pfam13191 316274000876 Predicted ATPase [General function prediction only]; Region: COG3903 316274000877 Walker A motif; other site 316274000878 ATP binding site [chemical binding]; other site 316274000879 Walker B motif; other site 316274000880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000881 TPR motif; other site 316274000882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000883 binding surface 316274000884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274000886 binding surface 316274000887 TPR motif; other site 316274000888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274000889 MarR family; Region: MarR_2; cl17246 316274000890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274000891 Low affinity iron permease; Region: Iron_permease; pfam04120 316274000892 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 316274000893 Cupin domain; Region: Cupin_2; cl17218 316274000894 XisH protein; Region: XisH; pfam08814 316274000895 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274000896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274000897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 316274000898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000899 ATP binding site [chemical binding]; other site 316274000900 Mg2+ binding site [ion binding]; other site 316274000901 G-X-G motif; other site 316274000902 XisI protein; Region: XisI; pfam08869 316274000903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274000904 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 316274000905 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 316274000906 Domain of unknown function (DUF377); Region: DUF377; pfam04041 316274000907 active site 316274000908 EamA-like transporter family; Region: EamA; pfam00892 316274000909 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274000910 EamA-like transporter family; Region: EamA; pfam00892 316274000911 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 316274000912 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 316274000913 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 316274000914 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 316274000915 generic binding surface II; other site 316274000916 ssDNA binding site; other site 316274000917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274000918 ATP binding site [chemical binding]; other site 316274000919 putative Mg++ binding site [ion binding]; other site 316274000920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274000921 nucleotide binding region [chemical binding]; other site 316274000922 ATP-binding site [chemical binding]; other site 316274000923 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 316274000924 elongation factor G; Reviewed; Region: PRK12740 316274000925 G1 box; other site 316274000926 putative GEF interaction site [polypeptide binding]; other site 316274000927 GTP/Mg2+ binding site [chemical binding]; other site 316274000928 Switch I region; other site 316274000929 G2 box; other site 316274000930 G3 box; other site 316274000931 Switch II region; other site 316274000932 G4 box; other site 316274000933 G5 box; other site 316274000934 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316274000935 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 316274000936 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316274000937 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 316274000938 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 316274000939 MviN-like protein; Region: MVIN; pfam03023 316274000940 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274000941 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274000942 Cellulose binding domain; Region: CBM_2; pfam00553 316274000943 Cellulose binding domain; Region: CBM_2; pfam00553 316274000944 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 316274000945 endoglucanase; Region: PLN02308 316274000946 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 316274000947 Cellulose binding domain; Region: CBM_3; smart01067 316274000948 Cellulose binding domain; Region: CBM_2; pfam00553 316274000949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274000950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274000951 DNA binding site [nucleotide binding] 316274000952 domain linker motif; other site 316274000953 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274000954 dimerization interface [polypeptide binding]; other site 316274000955 ligand binding site [chemical binding]; other site 316274000956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274000957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274000958 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 316274000959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274000960 dimer interface [polypeptide binding]; other site 316274000961 conserved gate region; other site 316274000962 putative PBP binding loops; other site 316274000963 ABC-ATPase subunit interface; other site 316274000964 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274000966 dimer interface [polypeptide binding]; other site 316274000967 conserved gate region; other site 316274000968 putative PBP binding loops; other site 316274000969 ABC-ATPase subunit interface; other site 316274000970 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 316274000971 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 316274000972 Protein of unknown function, DUF608; Region: DUF608; pfam04685 316274000973 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 316274000974 L11 interface [polypeptide binding]; other site 316274000975 putative EF-Tu interaction site [polypeptide binding]; other site 316274000976 putative EF-G interaction site [polypeptide binding]; other site 316274000977 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 316274000978 L11 interface [polypeptide binding]; other site 316274000979 putative EF-Tu interaction site [polypeptide binding]; other site 316274000980 putative EF-G interaction site [polypeptide binding]; other site 316274000981 Rdx family; Region: Rdx; pfam10262 316274000982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274000984 NAD(P) binding site [chemical binding]; other site 316274000985 active site 316274000986 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274000987 GAF domain; Region: GAF_3; pfam13492 316274000988 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274000989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274000990 dimer interface [polypeptide binding]; other site 316274000991 phosphorylation site [posttranslational modification] 316274000992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274000993 ATP binding site [chemical binding]; other site 316274000994 Mg2+ binding site [ion binding]; other site 316274000995 G-X-G motif; other site 316274000996 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274000997 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274000998 ligand binding site [chemical binding]; other site 316274000999 flexible hinge region; other site 316274001000 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316274001001 Predicted integral membrane protein [Function unknown]; Region: COG5637 316274001002 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 316274001003 putative hydrophobic ligand binding site [chemical binding]; other site 316274001004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316274001005 Protein of unknown function (DUF419); Region: DUF419; pfam04237 316274001006 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 316274001007 putative active site [active] 316274001008 catalytic residue [active] 316274001009 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274001010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274001011 S-adenosylmethionine binding site [chemical binding]; other site 316274001012 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316274001013 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 316274001014 nucleotide binding site [chemical binding]; other site 316274001015 NEF interaction site [polypeptide binding]; other site 316274001016 SBD interface [polypeptide binding]; other site 316274001017 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 316274001018 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 316274001019 putative hydrolase; Provisional; Region: PRK02113 316274001020 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274001021 DNA methylase; Region: N6_N4_Mtase; pfam01555 316274001022 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274001023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274001024 Zn2+ binding site [ion binding]; other site 316274001025 Mg2+ binding site [ion binding]; other site 316274001026 heat shock protein 90; Provisional; Region: PRK05218 316274001027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001028 ATP binding site [chemical binding]; other site 316274001029 Mg2+ binding site [ion binding]; other site 316274001030 G-X-G motif; other site 316274001031 RNA ligase; Region: RNA_ligase; pfam09414 316274001032 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 316274001033 Cellulose binding domain; Region: CBM_2; pfam00553 316274001034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274001035 antiporter inner membrane protein; Provisional; Region: PRK11670 316274001036 Domain of unknown function DUF59; Region: DUF59; pfam01883 316274001037 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 316274001038 Walker A motif; other site 316274001039 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 316274001040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274001041 FeS/SAM binding site; other site 316274001042 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 316274001043 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 316274001044 hydrophobic ligand binding site; other site 316274001045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274001046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274001047 Family description; Region: VCBS; pfam13517 316274001048 Family description; Region: VCBS; pfam13517 316274001049 hypothetical protein; Provisional; Region: PRK10279 316274001050 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274001051 nucleophile elbow; other site 316274001052 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274001053 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274001054 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274001055 active site 316274001056 ATP binding site [chemical binding]; other site 316274001057 substrate binding site [chemical binding]; other site 316274001058 activation loop (A-loop); other site 316274001059 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 316274001060 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 316274001061 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274001062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274001063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274001064 Walker A/P-loop; other site 316274001065 ATP binding site [chemical binding]; other site 316274001066 Q-loop/lid; other site 316274001067 ABC transporter signature motif; other site 316274001068 Walker B; other site 316274001069 D-loop; other site 316274001070 H-loop/switch region; other site 316274001071 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274001072 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 316274001073 putative NAD(P) binding site [chemical binding]; other site 316274001074 structural Zn binding site [ion binding]; other site 316274001075 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 316274001076 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 316274001077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274001078 catalytic loop [active] 316274001079 iron binding site [ion binding]; other site 316274001080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274001081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274001082 active site 316274001083 catalytic tetrad [active] 316274001084 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 316274001085 active site 316274001086 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 316274001087 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 316274001088 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 316274001089 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274001090 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274001091 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316274001092 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316274001093 protein binding site [polypeptide binding]; other site 316274001094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274001095 dimer interface [polypeptide binding]; other site 316274001096 conserved gate region; other site 316274001097 putative PBP binding loops; other site 316274001098 ABC-ATPase subunit interface; other site 316274001099 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 316274001100 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 316274001101 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 316274001102 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 316274001103 Walker A/P-loop; other site 316274001104 ATP binding site [chemical binding]; other site 316274001105 Q-loop/lid; other site 316274001106 ABC transporter signature motif; other site 316274001107 Walker B; other site 316274001108 D-loop; other site 316274001109 H-loop/switch region; other site 316274001110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274001111 dimer interface [polypeptide binding]; other site 316274001112 conserved gate region; other site 316274001113 ABC-ATPase subunit interface; other site 316274001114 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 316274001115 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 316274001116 fatty acid metabolism regulator; Provisional; Region: PRK04984 316274001117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274001118 DNA-binding site [nucleotide binding]; DNA binding site 316274001119 FadR C-terminal domain; Region: FadR_C; pfam07840 316274001120 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316274001121 FAD binding domain; Region: FAD_binding_4; pfam01565 316274001122 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 316274001123 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316274001124 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274001125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274001126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274001127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274001128 active site 316274001129 catalytic tetrad [active] 316274001130 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274001131 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274001132 homodimer interface [polypeptide binding]; other site 316274001133 active site 316274001134 TDP-binding site; other site 316274001135 acceptor substrate-binding pocket; other site 316274001136 EDD domain protein, DegV family; Region: DegV; TIGR00762 316274001137 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 316274001138 EDD domain protein, DegV family; Region: DegV; TIGR00762 316274001139 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 316274001140 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 316274001141 DAK2 domain; Region: Dak2; pfam02734 316274001142 Asp23 family; Region: Asp23; pfam03780 316274001143 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 316274001144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274001145 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274001146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274001147 DNA binding residues [nucleotide binding] 316274001148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274001149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274001150 dimer interface [polypeptide binding]; other site 316274001151 conserved gate region; other site 316274001152 putative PBP binding loops; other site 316274001153 ABC-ATPase subunit interface; other site 316274001154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274001155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274001156 dimer interface [polypeptide binding]; other site 316274001157 conserved gate region; other site 316274001158 putative PBP binding loops; other site 316274001159 ABC-ATPase subunit interface; other site 316274001160 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274001161 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 316274001162 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274001163 classical (c) SDRs; Region: SDR_c; cd05233 316274001164 NAD(P) binding site [chemical binding]; other site 316274001165 active site 316274001166 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 316274001167 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316274001168 dimer interface [polypeptide binding]; other site 316274001169 active site 316274001170 CoA binding pocket [chemical binding]; other site 316274001171 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274001172 homodimer interface [polypeptide binding]; other site 316274001173 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274001174 active site 316274001175 TDP-binding site; other site 316274001176 acceptor substrate-binding pocket; other site 316274001177 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 316274001178 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 316274001179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274001180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274001181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001182 NAD(P) binding site [chemical binding]; other site 316274001183 active site 316274001184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274001185 active site 316274001186 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274001187 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274001188 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274001189 G1 box; other site 316274001190 GTP/Mg2+ binding site [chemical binding]; other site 316274001191 G2 box; other site 316274001192 Switch I region; other site 316274001193 G3 box; other site 316274001194 Switch II region; other site 316274001195 G4 box; other site 316274001196 G5 box; other site 316274001197 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274001198 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 316274001199 heme-binding site [chemical binding]; other site 316274001200 UV-endonuclease UvdE; Region: UvdE; cl10036 316274001201 phosphoglycolate phosphatase; Provisional; Region: PRK13222 316274001202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274001203 motif II; other site 316274001204 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 316274001205 tetramerization interface [polypeptide binding]; other site 316274001206 active site 316274001207 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 316274001208 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 316274001209 dimer interface [polypeptide binding]; other site 316274001210 putative functional site; other site 316274001211 putative MPT binding site; other site 316274001212 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 316274001213 PLD-like domain; Region: PLDc_2; pfam13091 316274001214 putative active site [active] 316274001215 catalytic site [active] 316274001216 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 316274001217 PLD-like domain; Region: PLDc_2; pfam13091 316274001218 putative active site [active] 316274001219 catalytic site [active] 316274001220 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 316274001221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001222 Walker A motif; other site 316274001223 ATP binding site [chemical binding]; other site 316274001224 Walker B motif; other site 316274001225 arginine finger; other site 316274001226 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 316274001227 putative homodimer interface [polypeptide binding]; other site 316274001228 putative homotetramer interface [polypeptide binding]; other site 316274001229 allosteric switch controlling residues; other site 316274001230 putative metal binding site [ion binding]; other site 316274001231 putative homodimer-homodimer interface [polypeptide binding]; other site 316274001232 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274001233 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 316274001234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 316274001235 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274001236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274001237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274001238 DNA binding residues [nucleotide binding] 316274001239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316274001240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316274001241 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 316274001242 putative dimerization interface [polypeptide binding]; other site 316274001243 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 316274001244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274001245 metal ion-dependent adhesion site (MIDAS); other site 316274001246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274001247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274001248 dimerization interface [polypeptide binding]; other site 316274001249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001250 dimer interface [polypeptide binding]; other site 316274001251 phosphorylation site [posttranslational modification] 316274001252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001253 ATP binding site [chemical binding]; other site 316274001254 Mg2+ binding site [ion binding]; other site 316274001255 G-X-G motif; other site 316274001256 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274001257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274001258 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 316274001259 active site 316274001260 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 316274001261 active site 316274001262 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 316274001263 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 316274001264 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 316274001265 Shoulder domain; Region: MVP_shoulder; pfam11978 316274001266 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274001267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274001268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274001269 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316274001270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274001271 NAD(P) binding site [chemical binding]; other site 316274001272 active site 316274001273 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 316274001274 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 316274001275 active site residue [active] 316274001276 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 316274001277 active site residue [active] 316274001278 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 316274001279 [2Fe-2S] cluster binding site [ion binding]; other site 316274001280 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 316274001281 FeS assembly protein SufB; Region: sufB; TIGR01980 316274001282 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 316274001283 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316274001284 trimerization site [polypeptide binding]; other site 316274001285 active site 316274001286 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274001287 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 316274001288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274001289 catalytic residue [active] 316274001290 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 316274001291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 316274001292 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 316274001293 FeS assembly protein SufD; Region: sufD; TIGR01981 316274001294 FeS assembly ATPase SufC; Region: sufC; TIGR01978 316274001295 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 316274001296 Walker A/P-loop; other site 316274001297 ATP binding site [chemical binding]; other site 316274001298 Q-loop/lid; other site 316274001299 ABC transporter signature motif; other site 316274001300 Walker B; other site 316274001301 D-loop; other site 316274001302 H-loop/switch region; other site 316274001303 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 316274001304 Predicted transcriptional regulator [Transcription]; Region: COG2345 316274001305 putative Zn2+ binding site [ion binding]; other site 316274001306 putative DNA binding site [nucleotide binding]; other site 316274001307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001308 Coenzyme A binding pocket [chemical binding]; other site 316274001309 Right handed beta helix region; Region: Beta_helix; pfam13229 316274001310 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 316274001311 generic binding surface I; other site 316274001312 generic binding surface II; other site 316274001313 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274001314 putative catalytic site [active] 316274001315 putative metal binding site [ion binding]; other site 316274001316 putative phosphate binding site [ion binding]; other site 316274001317 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274001318 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 316274001319 NHL repeat; Region: NHL; pfam01436 316274001320 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 316274001321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274001322 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274001323 Walker A/P-loop; other site 316274001324 ATP binding site [chemical binding]; other site 316274001325 Q-loop/lid; other site 316274001326 ABC transporter signature motif; other site 316274001327 Walker B; other site 316274001328 D-loop; other site 316274001329 H-loop/switch region; other site 316274001330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 316274001331 active site 316274001332 substrate-binding site [chemical binding]; other site 316274001333 metal-binding site [ion binding] 316274001334 GTP binding site [chemical binding]; other site 316274001335 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 316274001336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274001337 Walker A/P-loop; other site 316274001338 ATP binding site [chemical binding]; other site 316274001339 Q-loop/lid; other site 316274001340 ABC transporter signature motif; other site 316274001341 Walker B; other site 316274001342 D-loop; other site 316274001343 H-loop/switch region; other site 316274001344 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 316274001345 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 316274001346 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 316274001347 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 316274001348 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 316274001349 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 316274001350 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 316274001351 active site 316274001352 Zn binding site [ion binding]; other site 316274001353 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 316274001354 HTH domain; Region: HTH_11; pfam08279 316274001355 GrpE; Region: GrpE; pfam01025 316274001356 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 316274001357 dimer interface [polypeptide binding]; other site 316274001358 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 316274001359 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316274001360 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 316274001361 nucleotide binding site [chemical binding]; other site 316274001362 NEF interaction site [polypeptide binding]; other site 316274001363 SBD interface [polypeptide binding]; other site 316274001364 chaperone protein DnaJ; Provisional; Region: PRK10767 316274001365 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316274001366 HSP70 interaction site [polypeptide binding]; other site 316274001367 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 316274001368 substrate binding site [polypeptide binding]; other site 316274001369 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 316274001370 Zn binding sites [ion binding]; other site 316274001371 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316274001372 dimer interface [polypeptide binding]; other site 316274001373 Probable zinc-binding domain; Region: zf-trcl; pfam13451 316274001374 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 316274001375 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 316274001376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316274001377 substrate binding pocket [chemical binding]; other site 316274001378 membrane-bound complex binding site; other site 316274001379 hinge residues; other site 316274001380 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316274001381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001382 dimer interface [polypeptide binding]; other site 316274001383 phosphorylation site [posttranslational modification] 316274001384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001385 ATP binding site [chemical binding]; other site 316274001386 Mg2+ binding site [ion binding]; other site 316274001387 G-X-G motif; other site 316274001388 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001390 active site 316274001391 phosphorylation site [posttranslational modification] 316274001392 intermolecular recognition site; other site 316274001393 dimerization interface [polypeptide binding]; other site 316274001394 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316274001395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274001396 motif II; other site 316274001397 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 316274001398 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274001399 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274001400 active site 316274001401 catalytic tetrad [active] 316274001402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001404 active site 316274001405 phosphorylation site [posttranslational modification] 316274001406 intermolecular recognition site; other site 316274001407 dimerization interface [polypeptide binding]; other site 316274001408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274001409 DNA binding site [nucleotide binding] 316274001410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001411 dimer interface [polypeptide binding]; other site 316274001412 phosphorylation site [posttranslational modification] 316274001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001414 ATP binding site [chemical binding]; other site 316274001415 Mg2+ binding site [ion binding]; other site 316274001416 G-X-G motif; other site 316274001417 OsmC-like protein; Region: OsmC; cl00767 316274001418 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001419 GAF domain; Region: GAF; pfam01590 316274001420 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274001421 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 316274001422 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 316274001423 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 316274001424 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316274001425 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274001427 S-adenosylmethionine binding site [chemical binding]; other site 316274001428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274001429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274001430 DNA binding site [nucleotide binding] 316274001431 domain linker motif; other site 316274001432 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274001433 dimerization interface [polypeptide binding]; other site 316274001434 ligand binding site [chemical binding]; other site 316274001435 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 316274001436 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316274001437 Phosphotransferase enzyme family; Region: APH; pfam01636 316274001438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274001439 active site 316274001440 ATP binding site [chemical binding]; other site 316274001441 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316274001442 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 316274001443 DoxX; Region: DoxX; pfam07681 316274001444 Iron permease FTR1 family; Region: FTR1; cl00475 316274001445 Imelysin; Region: Peptidase_M75; cl09159 316274001446 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316274001447 Domain of unknown function DUF21; Region: DUF21; pfam01595 316274001448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316274001449 Transporter associated domain; Region: CorC_HlyC; smart01091 316274001450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274001451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316274001452 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 316274001453 NusA N-terminal domain; Region: NusA_N; pfam08529 316274001454 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 316274001455 RNA binding site [nucleotide binding]; other site 316274001456 homodimer interface [polypeptide binding]; other site 316274001457 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316274001458 G-X-X-G motif; other site 316274001459 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316274001460 G-X-X-G motif; other site 316274001461 Protein of unknown function (DUF448); Region: DUF448; pfam04296 316274001462 putative RNA binding cleft [nucleotide binding]; other site 316274001463 translation initiation factor IF-2; Region: IF-2; TIGR00487 316274001464 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316274001465 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 316274001466 G1 box; other site 316274001467 putative GEF interaction site [polypeptide binding]; other site 316274001468 GTP/Mg2+ binding site [chemical binding]; other site 316274001469 Switch I region; other site 316274001470 G2 box; other site 316274001471 G3 box; other site 316274001472 Switch II region; other site 316274001473 G4 box; other site 316274001474 G5 box; other site 316274001475 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 316274001476 Translation-initiation factor 2; Region: IF-2; pfam11987 316274001477 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 316274001478 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 316274001479 DHH family; Region: DHH; pfam01368 316274001480 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 316274001481 DHHA1 domain; Region: DHHA1; pfam02272 316274001482 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 316274001483 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 316274001484 RNA binding site [nucleotide binding]; other site 316274001485 active site 316274001486 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274001487 metal ion-dependent adhesion site (MIDAS); other site 316274001488 Protein phosphatase 2C; Region: PP2C_2; pfam13672 316274001489 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001490 active site 316274001491 ATP binding site [chemical binding]; other site 316274001492 substrate binding site [chemical binding]; other site 316274001493 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274001494 substrate binding site [chemical binding]; other site 316274001495 activation loop (A-loop); other site 316274001496 activation loop (A-loop); other site 316274001497 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274001498 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274001499 chromosome segregation protein; Provisional; Region: PRK02224 316274001500 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 316274001501 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316274001502 TPP-binding site [chemical binding]; other site 316274001503 dimer interface [polypeptide binding]; other site 316274001504 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316274001505 PYR/PP interface [polypeptide binding]; other site 316274001506 dimer interface [polypeptide binding]; other site 316274001507 TPP binding site [chemical binding]; other site 316274001508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274001509 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 316274001510 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316274001511 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274001512 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 316274001513 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 316274001514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274001515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274001516 ligand binding site [chemical binding]; other site 316274001517 flexible hinge region; other site 316274001518 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274001519 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274001520 glutamate carboxypeptidase; Reviewed; Region: PRK06133 316274001521 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 316274001522 metal binding site [ion binding]; metal-binding site 316274001523 dimer interface [polypeptide binding]; other site 316274001524 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 316274001525 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 316274001526 putative active site [active] 316274001527 putative FMN binding site [chemical binding]; other site 316274001528 putative substrate binding site [chemical binding]; other site 316274001529 putative catalytic residue [active] 316274001530 Domain of unknown function (DUF309); Region: DUF309; cl00667 316274001531 Double zinc ribbon; Region: DZR; pfam12773 316274001532 thymidylate kinase; Validated; Region: tmk; PRK00698 316274001533 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 316274001534 TMP-binding site; other site 316274001535 ATP-binding site [chemical binding]; other site 316274001536 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 316274001537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001538 Walker A motif; other site 316274001539 ATP binding site [chemical binding]; other site 316274001540 Walker B motif; other site 316274001541 Phage tail tube protein; Region: Tail_tube; pfam10618 316274001542 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 316274001543 RxxxH motif; other site 316274001544 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316274001545 RNA binding site [nucleotide binding]; other site 316274001546 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316274001547 RNA binding site [nucleotide binding]; other site 316274001548 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 316274001549 RNA binding site [nucleotide binding]; other site 316274001550 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316274001551 RNA binding site [nucleotide binding]; other site 316274001552 Clp protease ATP binding subunit; Region: clpC; CHL00095 316274001553 Clp amino terminal domain; Region: Clp_N; pfam02861 316274001554 Clp amino terminal domain; Region: Clp_N; pfam02861 316274001555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001556 Walker A motif; other site 316274001557 ATP binding site [chemical binding]; other site 316274001558 Walker B motif; other site 316274001559 arginine finger; other site 316274001560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001561 Walker A motif; other site 316274001562 ATP binding site [chemical binding]; other site 316274001563 Walker B motif; other site 316274001564 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274001565 YceI-like domain; Region: YceI; pfam04264 316274001566 Phosphotransferase enzyme family; Region: APH; pfam01636 316274001567 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274001568 active site 316274001569 ATP binding site [chemical binding]; other site 316274001570 cystathionine gamma-synthase; Provisional; Region: PRK07811 316274001571 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316274001572 homodimer interface [polypeptide binding]; other site 316274001573 substrate-cofactor binding pocket; other site 316274001574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274001575 catalytic residue [active] 316274001576 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 316274001577 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 316274001578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274001579 active site 316274001580 nucleotide binding site [chemical binding]; other site 316274001581 HIGH motif; other site 316274001582 KMSKS motif; other site 316274001583 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 316274001584 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274001585 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 316274001586 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 316274001587 cleavage site 316274001588 active site 316274001589 substrate binding sites [chemical binding]; other site 316274001590 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 316274001591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274001592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274001593 non-specific DNA binding site [nucleotide binding]; other site 316274001594 salt bridge; other site 316274001595 sequence-specific DNA binding site [nucleotide binding]; other site 316274001596 PQQ-like domain; Region: PQQ_2; pfam13360 316274001597 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 316274001598 putative acyltransferase; Provisional; Region: PRK05790 316274001599 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274001600 dimer interface [polypeptide binding]; other site 316274001601 active site 316274001602 hypothetical protein; Validated; Region: PRK08116 316274001603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001604 Walker A motif; other site 316274001605 ATP binding site [chemical binding]; other site 316274001606 Walker B motif; other site 316274001607 arginine finger; other site 316274001608 Helix-turn-helix domain; Region: HTH_36; pfam13730 316274001609 Helix-turn-helix domain; Region: HTH_19; pfam12844 316274001610 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274001611 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 316274001612 cofactor binding site; other site 316274001613 DNA binding site [nucleotide binding] 316274001614 substrate interaction site [chemical binding]; other site 316274001615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001616 ATP binding site [chemical binding]; other site 316274001617 Mg2+ binding site [ion binding]; other site 316274001618 G-X-G motif; other site 316274001619 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 316274001620 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 316274001621 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 316274001622 PRTRC system protein A; Region: PRTRC_A; TIGR03735 316274001623 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 316274001624 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 316274001625 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 316274001626 ATP binding site [chemical binding]; other site 316274001627 substrate interface [chemical binding]; other site 316274001628 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 316274001629 Replication-relaxation; Region: Replic_Relax; pfam13814 316274001630 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274001631 Uncharacterized conserved protein [Function unknown]; Region: COG1479 316274001632 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274001633 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274001634 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 316274001635 AAA domain; Region: AAA_23; pfam13476 316274001636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274001637 Walker A/P-loop; other site 316274001638 ATP binding site [chemical binding]; other site 316274001639 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 316274001640 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 316274001641 Phage-related protein [Function unknown]; Region: COG5412 316274001642 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 316274001643 large terminase protein; Provisional; Region: 17; PHA02533 316274001644 Terminase small subunit; Region: Terminase_2; pfam03592 316274001645 DinB superfamily; Region: DinB_2; pfam12867 316274001646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274001647 dimerization interface [polypeptide binding]; other site 316274001648 putative DNA binding site [nucleotide binding]; other site 316274001649 putative Zn2+ binding site [ion binding]; other site 316274001650 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 316274001651 putative hydrophobic ligand binding site [chemical binding]; other site 316274001652 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316274001653 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 316274001654 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 316274001655 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 316274001656 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 316274001657 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 316274001658 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 316274001659 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 316274001660 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 316274001661 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316274001662 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274001663 active site 316274001664 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316274001665 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001667 active site 316274001668 phosphorylation site [posttranslational modification] 316274001669 intermolecular recognition site; other site 316274001670 dimerization interface [polypeptide binding]; other site 316274001671 Helix-turn-helix domain; Region: HTH_25; pfam13413 316274001672 non-specific DNA binding site [nucleotide binding]; other site 316274001673 salt bridge; other site 316274001674 sequence-specific DNA binding site [nucleotide binding]; other site 316274001675 HEAT repeats; Region: HEAT_2; pfam13646 316274001676 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 316274001677 phosphate binding site [ion binding]; other site 316274001678 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001680 active site 316274001681 phosphorylation site [posttranslational modification] 316274001682 intermolecular recognition site; other site 316274001683 dimerization interface [polypeptide binding]; other site 316274001684 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 316274001685 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 316274001686 Zn binding site [ion binding]; other site 316274001687 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 316274001688 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 316274001689 dimer interface [polypeptide binding]; other site 316274001690 [2Fe-2S] cluster binding site [ion binding]; other site 316274001691 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274001692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001693 active site 316274001694 phosphorylation site [posttranslational modification] 316274001695 intermolecular recognition site; other site 316274001696 dimerization interface [polypeptide binding]; other site 316274001697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274001698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001699 dimer interface [polypeptide binding]; other site 316274001700 phosphorylation site [posttranslational modification] 316274001701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001702 ATP binding site [chemical binding]; other site 316274001703 Mg2+ binding site [ion binding]; other site 316274001704 G-X-G motif; other site 316274001705 Cache domain; Region: Cache_1; pfam02743 316274001706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274001707 dimerization interface [polypeptide binding]; other site 316274001708 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001709 GAF domain; Region: GAF; pfam01590 316274001710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001711 dimer interface [polypeptide binding]; other site 316274001712 phosphorylation site [posttranslational modification] 316274001713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001714 ATP binding site [chemical binding]; other site 316274001715 Mg2+ binding site [ion binding]; other site 316274001716 G-X-G motif; other site 316274001717 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274001718 Ligand Binding Site [chemical binding]; other site 316274001719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274001720 Ligand Binding Site [chemical binding]; other site 316274001721 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 316274001722 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 316274001723 glutamine binding [chemical binding]; other site 316274001724 catalytic triad [active] 316274001725 Fic/DOC family; Region: Fic; cl00960 316274001726 Fic/DOC family; Region: Fic; cl00960 316274001727 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274001728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274001729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274001730 DNA binding residues [nucleotide binding] 316274001731 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274001732 GAF domain; Region: GAF_3; pfam13492 316274001733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274001734 Histidine kinase; Region: HisKA_3; pfam07730 316274001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001736 ATP binding site [chemical binding]; other site 316274001737 Mg2+ binding site [ion binding]; other site 316274001738 G-X-G motif; other site 316274001739 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 316274001740 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274001741 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001743 active site 316274001744 phosphorylation site [posttranslational modification] 316274001745 intermolecular recognition site; other site 316274001746 dimerization interface [polypeptide binding]; other site 316274001747 Response regulator receiver domain; Region: Response_reg; pfam00072 316274001748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001749 active site 316274001750 phosphorylation site [posttranslational modification] 316274001751 intermolecular recognition site; other site 316274001752 dimerization interface [polypeptide binding]; other site 316274001753 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316274001754 cyclase homology domain; Region: CHD; cd07302 316274001755 nucleotidyl binding site; other site 316274001756 metal binding site [ion binding]; metal-binding site 316274001757 dimer interface [polypeptide binding]; other site 316274001758 PAS fold; Region: PAS_4; pfam08448 316274001759 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274001760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274001761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274001762 dimer interface [polypeptide binding]; other site 316274001763 phosphorylation site [posttranslational modification] 316274001764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274001765 ATP binding site [chemical binding]; other site 316274001766 Mg2+ binding site [ion binding]; other site 316274001767 G-X-G motif; other site 316274001768 imidazolonepropionase; Validated; Region: PRK09356 316274001769 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 316274001770 active site 316274001771 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274001772 HTH domain; Region: HTH_11; pfam08279 316274001773 WYL domain; Region: WYL; pfam13280 316274001774 phytoene desaturase; Region: crtI_fam; TIGR02734 316274001775 Thioredoxin; Region: Thioredoxin_4; pfam13462 316274001776 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274001777 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 316274001778 substrate binding site [chemical binding]; other site 316274001779 putative active site [active] 316274001780 redox center [active] 316274001781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274001782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001783 Coenzyme A binding pocket [chemical binding]; other site 316274001784 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 316274001785 Peptidase family M50; Region: Peptidase_M50; pfam02163 316274001786 active site 316274001787 putative substrate binding region [chemical binding]; other site 316274001788 FOG: CBS domain [General function prediction only]; Region: COG0517 316274001789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 316274001790 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274001791 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316274001792 structural tetrad; other site 316274001793 TRAM domain; Region: TRAM; pfam01938 316274001794 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 316274001795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274001796 S-adenosylmethionine binding site [chemical binding]; other site 316274001797 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 316274001798 proposed catalytic triad [active] 316274001799 active site nucleophile [active] 316274001800 cyanophycin synthetase; Provisional; Region: PRK14016 316274001801 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 316274001802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274001803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274001804 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 316274001805 Domain of unknown function (DUF814); Region: DUF814; pfam05670 316274001806 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 316274001807 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 316274001808 catalytic site [active] 316274001809 G-X2-G-X-G-K; other site 316274001810 EDD domain protein, DegV family; Region: DegV; TIGR00762 316274001811 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 316274001812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001813 Coenzyme A binding pocket [chemical binding]; other site 316274001814 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274001815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001816 Walker A motif; other site 316274001817 ATP binding site [chemical binding]; other site 316274001818 Walker B motif; other site 316274001819 arginine finger; other site 316274001820 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274001821 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274001822 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274001823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274001824 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274001825 Coenzyme A binding pocket [chemical binding]; other site 316274001826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274001827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274001828 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 316274001829 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 316274001830 multifunctional aminopeptidase A; Provisional; Region: PRK00913 316274001831 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 316274001832 interface (dimer of trimers) [polypeptide binding]; other site 316274001833 Substrate-binding/catalytic site; other site 316274001834 Zn-binding sites [ion binding]; other site 316274001835 urocanate hydratase; Provisional; Region: PRK05414 316274001836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 316274001837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274001838 PAS fold; Region: PAS; pfam00989 316274001839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274001840 putative active site [active] 316274001841 heme pocket [chemical binding]; other site 316274001842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274001843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274001844 metal binding site [ion binding]; metal-binding site 316274001845 active site 316274001846 I-site; other site 316274001847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274001848 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 316274001849 heme-binding site [chemical binding]; other site 316274001850 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 316274001851 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 316274001852 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274001853 active site clefts [active] 316274001854 zinc binding site [ion binding]; other site 316274001855 dimer interface [polypeptide binding]; other site 316274001856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274001857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274001858 active site 316274001859 metal binding site [ion binding]; metal-binding site 316274001860 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 316274001861 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274001862 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 316274001863 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274001864 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 316274001865 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 316274001866 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 316274001867 DNA binding site [nucleotide binding] 316274001868 Int/Topo IB signature motif; other site 316274001869 active site 316274001870 catalytic residues [active] 316274001871 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274001872 Calx-beta domain; Region: Calx-beta; cl02522 316274001873 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274001874 amidase catalytic site [active] 316274001875 Zn binding residues [ion binding]; other site 316274001876 substrate binding site [chemical binding]; other site 316274001877 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 316274001878 DNA-binding interface [nucleotide binding]; DNA binding site 316274001879 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 316274001880 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 316274001881 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316274001882 Replication-relaxation; Region: Replic_Relax; pfam13814 316274001883 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 316274001884 plasmid segregation protein ParM; Provisional; Region: PRK13917 316274001885 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 316274001886 Mg binding site [ion binding]; other site 316274001887 nucleotide binding site [chemical binding]; other site 316274001888 putative protofilament interface [polypeptide binding]; other site 316274001889 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 316274001890 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 316274001891 active site 316274001892 metal binding site [ion binding]; metal-binding site 316274001893 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 316274001894 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 316274001895 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274001896 active site 316274001897 Int/Topo IB signature motif; other site 316274001898 DNA binding site [nucleotide binding] 316274001899 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274001900 EamA-like transporter family; Region: EamA; pfam00892 316274001901 AAA domain; Region: AAA_21; pfam13304 316274001902 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274001903 nudix motif; other site 316274001904 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274001905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001906 Walker A motif; other site 316274001907 ATP binding site [chemical binding]; other site 316274001908 Walker B motif; other site 316274001909 arginine finger; other site 316274001910 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274001911 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 316274001912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274001913 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316274001914 Walker A/P-loop; other site 316274001915 ATP binding site [chemical binding]; other site 316274001916 Q-loop/lid; other site 316274001917 ABC transporter signature motif; other site 316274001918 Walker B; other site 316274001919 D-loop; other site 316274001920 H-loop/switch region; other site 316274001921 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316274001922 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316274001923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274001924 Walker A motif; other site 316274001925 ATP binding site [chemical binding]; other site 316274001926 Walker B motif; other site 316274001927 arginine finger; other site 316274001928 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 316274001929 NAD-dependent deacetylase; Provisional; Region: PRK00481 316274001930 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 316274001931 NAD+ binding site [chemical binding]; other site 316274001932 substrate binding site [chemical binding]; other site 316274001933 Zn binding site [ion binding]; other site 316274001934 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274001935 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 316274001936 putative acyl-acceptor binding pocket; other site 316274001937 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 316274001938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274001939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316274001940 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274001941 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274001942 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 316274001943 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 316274001944 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274001945 metal ion-dependent adhesion site (MIDAS); other site 316274001946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274001947 S-adenosylmethionine binding site [chemical binding]; other site 316274001948 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 316274001949 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 316274001950 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 316274001951 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 316274001952 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682 316274001953 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 316274001954 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 316274001955 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 316274001956 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 316274001957 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 316274001958 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274001959 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274001960 active site 316274001961 ATP binding site [chemical binding]; other site 316274001962 substrate binding site [chemical binding]; other site 316274001963 activation loop (A-loop); other site 316274001964 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274001965 Double zinc ribbon; Region: DZR; pfam12773 316274001966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274001967 phosphopeptide binding site; other site 316274001968 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274001969 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316274001970 Peptidase family U32; Region: Peptidase_U32; pfam01136 316274001971 Collagenase; Region: DUF3656; pfam12392 316274001972 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 316274001973 Peptidase family U32; Region: Peptidase_U32; cl03113 316274001974 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 316274001975 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 316274001976 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316274001977 EVE domain; Region: EVE; pfam01878 316274001978 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 316274001979 Domain of unknown function (DUF333); Region: DUF333; pfam03891 316274001980 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 316274001981 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274001982 Bacitracin resistance protein BacA; Region: BacA; pfam02673 316274001983 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 316274001984 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316274001985 inhibitor-cofactor binding pocket; inhibition site 316274001986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274001987 catalytic residue [active] 316274001988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274001990 active site 316274001991 phosphorylation site [posttranslational modification] 316274001992 intermolecular recognition site; other site 316274001993 dimerization interface [polypeptide binding]; other site 316274001994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274001995 DNA binding residues [nucleotide binding] 316274001996 dimerization interface [polypeptide binding]; other site 316274001997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274001998 Histidine kinase; Region: HisKA_3; pfam07730 316274001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002000 ATP binding site [chemical binding]; other site 316274002001 Mg2+ binding site [ion binding]; other site 316274002002 G-X-G motif; other site 316274002003 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 316274002004 dimer interface [polypeptide binding]; other site 316274002005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274002006 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274002007 HTH domain; Region: HTH_11; pfam08279 316274002008 WYL domain; Region: WYL; pfam13280 316274002009 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274002010 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 316274002011 putative NAD(P) binding site [chemical binding]; other site 316274002012 short chain dehydrogenase; Provisional; Region: PRK06179 316274002013 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 316274002014 NADP binding site [chemical binding]; other site 316274002015 active site 316274002016 steroid binding site; other site 316274002017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002019 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274002020 Double zinc ribbon; Region: DZR; pfam12773 316274002021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274002022 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274002023 active site 316274002024 ATP binding site [chemical binding]; other site 316274002025 substrate binding site [chemical binding]; other site 316274002026 activation loop (A-loop); other site 316274002027 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274002028 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274002029 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274002030 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274002031 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274002032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274002033 Walker A/P-loop; other site 316274002034 ATP binding site [chemical binding]; other site 316274002035 Q-loop/lid; other site 316274002036 ABC transporter signature motif; other site 316274002037 Walker B; other site 316274002038 D-loop; other site 316274002039 H-loop/switch region; other site 316274002040 ABC transporter; Region: ABC_tran_2; pfam12848 316274002041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274002042 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002044 active site 316274002045 phosphorylation site [posttranslational modification] 316274002046 intermolecular recognition site; other site 316274002047 dimerization interface [polypeptide binding]; other site 316274002048 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002049 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274002050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002052 dimer interface [polypeptide binding]; other site 316274002053 phosphorylation site [posttranslational modification] 316274002054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002055 ATP binding site [chemical binding]; other site 316274002056 Mg2+ binding site [ion binding]; other site 316274002057 G-X-G motif; other site 316274002058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002060 active site 316274002061 phosphorylation site [posttranslational modification] 316274002062 intermolecular recognition site; other site 316274002063 dimerization interface [polypeptide binding]; other site 316274002064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274002065 DNA binding site [nucleotide binding] 316274002066 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274002067 cheY-homologous receiver domain; Region: REC; smart00448 316274002068 phosphorylation site [posttranslational modification] 316274002069 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 316274002070 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316274002071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316274002072 dimer interface [polypeptide binding]; other site 316274002073 putative CheW interface [polypeptide binding]; other site 316274002074 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316274002075 putative binding surface; other site 316274002076 active site 316274002077 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316274002078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002079 ATP binding site [chemical binding]; other site 316274002080 Mg2+ binding site [ion binding]; other site 316274002081 G-X-G motif; other site 316274002082 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316274002083 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274002084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002085 active site 316274002086 phosphorylation site [posttranslational modification] 316274002087 intermolecular recognition site; other site 316274002088 dimerization interface [polypeptide binding]; other site 316274002089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002091 active site 316274002092 phosphorylation site [posttranslational modification] 316274002093 intermolecular recognition site; other site 316274002094 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316274002095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002096 active site 316274002097 phosphorylation site [posttranslational modification] 316274002098 intermolecular recognition site; other site 316274002099 dimerization interface [polypeptide binding]; other site 316274002100 CheB methylesterase; Region: CheB_methylest; pfam01339 316274002101 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316274002102 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316274002103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002104 TPR motif; other site 316274002105 binding surface 316274002106 TPR repeat; Region: TPR_11; pfam13414 316274002107 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274002108 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274002109 TPR repeat; Region: TPR_11; pfam13414 316274002110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002111 binding surface 316274002112 TPR motif; other site 316274002113 TPR repeat; Region: TPR_11; pfam13414 316274002114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002115 binding surface 316274002116 TPR motif; other site 316274002117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002118 binding surface 316274002119 TPR motif; other site 316274002120 TPR repeat; Region: TPR_11; pfam13414 316274002121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002122 binding surface 316274002123 TPR repeat; Region: TPR_11; pfam13414 316274002124 TPR motif; other site 316274002125 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274002126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002127 ATP binding site [chemical binding]; other site 316274002128 Mg2+ binding site [ion binding]; other site 316274002129 G-X-G motif; other site 316274002130 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274002131 anti sigma factor interaction site; other site 316274002132 regulatory phosphorylation site [posttranslational modification]; other site 316274002133 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 316274002134 dinuclear metal binding motif [ion binding]; other site 316274002135 Predicted transcriptional regulators [Transcription]; Region: COG1695 316274002136 Transcriptional regulator PadR-like family; Region: PadR; cl17335 316274002137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274002138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316274002139 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 316274002140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274002141 S-adenosylmethionine binding site [chemical binding]; other site 316274002142 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 316274002143 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 316274002144 active site 316274002145 (T/H)XGH motif; other site 316274002146 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 316274002147 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 316274002148 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 316274002149 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316274002150 dimer interface [polypeptide binding]; other site 316274002151 active site 316274002152 CoA binding pocket [chemical binding]; other site 316274002153 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 316274002154 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274002155 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274002156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002157 NAD(P) binding site [chemical binding]; other site 316274002158 active site 316274002159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274002160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002161 NAD(P) binding site [chemical binding]; other site 316274002162 active site 316274002163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274002164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274002165 NAD(P) binding site [chemical binding]; other site 316274002166 active site 316274002167 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 316274002168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274002169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274002170 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316274002171 Asp23 family; Region: Asp23; pfam03780 316274002172 transcription antitermination factor NusB; Region: nusB; TIGR01951 316274002173 putative RNA binding site [nucleotide binding]; other site 316274002174 acyl carrier protein; Provisional; Region: acpP; PRK00982 316274002175 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 316274002176 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 316274002177 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 316274002178 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316274002179 active site 316274002180 HIGH motif; other site 316274002181 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316274002182 active site 316274002183 KMSKS motif; other site 316274002184 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 316274002185 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 316274002186 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 316274002187 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274002188 Ligand binding site; other site 316274002189 Ligand binding site; other site 316274002190 Ligand binding site; other site 316274002191 Putative Catalytic site; other site 316274002192 DXD motif; other site 316274002193 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 316274002194 active site 316274002195 catalytic residues [active] 316274002196 metal binding site [ion binding]; metal-binding site 316274002197 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 316274002198 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 316274002199 G-X-X-G motif; other site 316274002200 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 316274002201 RxxxH motif; other site 316274002202 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 316274002203 Haemolytic domain; Region: Haemolytic; pfam01809 316274002204 Ribonuclease P; Region: Ribonuclease_P; pfam00825 316274002205 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 316274002206 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274002207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 316274002208 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274002209 putative acyl-acceptor binding pocket; other site 316274002210 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 316274002211 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274002212 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274002213 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 316274002214 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 316274002215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316274002216 active site 316274002217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274002218 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274002220 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 316274002221 putative active site [active] 316274002222 putative CoA binding site [chemical binding]; other site 316274002223 nudix motif; other site 316274002224 metal binding site [ion binding]; metal-binding site 316274002225 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 316274002226 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 316274002227 Walker A/P-loop; other site 316274002228 ATP binding site [chemical binding]; other site 316274002229 Q-loop/lid; other site 316274002230 ABC transporter signature motif; other site 316274002231 Walker B; other site 316274002232 D-loop; other site 316274002233 H-loop/switch region; other site 316274002234 TOBE domain; Region: TOBE; pfam03459 316274002235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274002236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274002237 DNA binding site [nucleotide binding] 316274002238 domain linker motif; other site 316274002239 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274002240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274002241 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274002242 PGAP1-like protein; Region: PGAP1; pfam07819 316274002243 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 316274002244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274002245 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274002246 putative catalytic residues [active] 316274002247 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 316274002248 synthase/transferase; Region: PLN02316 316274002249 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 316274002250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274002251 RNA binding surface [nucleotide binding]; other site 316274002252 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 316274002253 active site 316274002254 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274002255 LVIVD repeat; Region: LVIVD; pfam08309 316274002256 LVIVD repeat; Region: LVIVD; pfam08309 316274002257 LVIVD repeat; Region: LVIVD; pfam08309 316274002258 LVIVD repeat; Region: LVIVD; pfam08309 316274002259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274002260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002261 Coenzyme A binding pocket [chemical binding]; other site 316274002262 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274002263 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 316274002264 DNA polymerase III subunit delta'; Validated; Region: PRK08485 316274002265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274002266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002267 Coenzyme A binding pocket [chemical binding]; other site 316274002268 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002270 active site 316274002271 phosphorylation site [posttranslational modification] 316274002272 intermolecular recognition site; other site 316274002273 dimerization interface [polypeptide binding]; other site 316274002274 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 316274002275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274002277 putative substrate translocation pore; other site 316274002278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274002279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002280 metal binding site [ion binding]; metal-binding site 316274002281 active site 316274002282 I-site; other site 316274002283 glycerol kinase; Provisional; Region: glpK; PRK00047 316274002284 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 316274002285 N- and C-terminal domain interface [polypeptide binding]; other site 316274002286 active site 316274002287 MgATP binding site [chemical binding]; other site 316274002288 catalytic site [active] 316274002289 metal binding site [ion binding]; metal-binding site 316274002290 putative homotetramer interface [polypeptide binding]; other site 316274002291 glycerol binding site [chemical binding]; other site 316274002292 homodimer interface [polypeptide binding]; other site 316274002293 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 316274002294 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274002295 Protein of unknown function DUF58; Region: DUF58; pfam01882 316274002296 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274002297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274002298 Walker A motif; other site 316274002299 ATP binding site [chemical binding]; other site 316274002300 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 316274002301 Walker B motif; other site 316274002302 arginine finger; other site 316274002303 PAS domain; Region: PAS; smart00091 316274002304 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274002305 putative active site [active] 316274002306 heme pocket [chemical binding]; other site 316274002307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002308 dimer interface [polypeptide binding]; other site 316274002309 phosphorylation site [posttranslational modification] 316274002310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002311 ATP binding site [chemical binding]; other site 316274002312 Mg2+ binding site [ion binding]; other site 316274002313 G-X-G motif; other site 316274002314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002316 active site 316274002317 phosphorylation site [posttranslational modification] 316274002318 intermolecular recognition site; other site 316274002319 dimerization interface [polypeptide binding]; other site 316274002320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274002321 DNA binding site [nucleotide binding] 316274002322 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 316274002323 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 316274002324 hemolysin; Provisional; Region: PRK15087 316274002325 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 316274002326 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 316274002327 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 316274002328 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316274002329 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316274002330 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 316274002331 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 316274002332 nucleotide binding pocket [chemical binding]; other site 316274002333 K-X-D-G motif; other site 316274002334 catalytic site [active] 316274002335 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 316274002336 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 316274002337 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 316274002338 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 316274002339 Dimer interface [polypeptide binding]; other site 316274002340 BRCT sequence motif; other site 316274002341 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 316274002342 hypothetical protein; Reviewed; Region: PRK09588 316274002343 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 316274002344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 316274002345 putative metal binding site [ion binding]; other site 316274002346 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 316274002347 active site 316274002348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002350 active site 316274002351 phosphorylation site [posttranslational modification] 316274002352 intermolecular recognition site; other site 316274002353 dimerization interface [polypeptide binding]; other site 316274002354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274002355 DNA binding site [nucleotide binding] 316274002356 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316274002357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002358 putative active site [active] 316274002359 heme pocket [chemical binding]; other site 316274002360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002361 dimer interface [polypeptide binding]; other site 316274002362 phosphorylation site [posttranslational modification] 316274002363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002364 ATP binding site [chemical binding]; other site 316274002365 Mg2+ binding site [ion binding]; other site 316274002366 G-X-G motif; other site 316274002367 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274002368 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274002369 Probable Catalytic site; other site 316274002370 metal-binding site 316274002371 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274002373 Galactose oxidase, central domain; Region: Kelch_3; cl02701 316274002374 Kelch motif; Region: Kelch_1; pfam01344 316274002375 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002376 Kelch motif; Region: Kelch_6; pfam13964 316274002377 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002378 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 316274002379 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 316274002380 ATP-binding site [chemical binding]; other site 316274002381 Sugar specificity; other site 316274002382 Pyrimidine base specificity; other site 316274002383 Caspase domain; Region: Peptidase_C14; pfam00656 316274002384 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 316274002385 putative heme binding pocket [chemical binding]; other site 316274002386 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 316274002387 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 316274002388 FAD binding domain; Region: FAD_binding_3; pfam01494 316274002389 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274002390 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 316274002391 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 316274002392 intracellular protease, PfpI family; Region: PfpI; TIGR01382 316274002393 proposed catalytic triad [active] 316274002394 conserved cys residue [active] 316274002395 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274002396 nudix motif; other site 316274002397 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 316274002398 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 316274002399 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 316274002400 hinge; other site 316274002401 active site 316274002402 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316274002403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002404 active site 316274002405 phosphorylation site [posttranslational modification] 316274002406 intermolecular recognition site; other site 316274002407 dimerization interface [polypeptide binding]; other site 316274002408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274002409 Walker A motif; other site 316274002410 ATP binding site [chemical binding]; other site 316274002411 Walker B motif; other site 316274002412 arginine finger; other site 316274002413 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 316274002414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316274002415 substrate binding site [chemical binding]; other site 316274002416 oxyanion hole (OAH) forming residues; other site 316274002417 trimer interface [polypeptide binding]; other site 316274002418 Domain of unknown function (DUF427); Region: DUF427; cl00998 316274002419 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 316274002420 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 316274002421 Ligand Binding Site [chemical binding]; other site 316274002422 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 316274002423 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274002424 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274002425 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274002426 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274002427 G1 box; other site 316274002428 GTP/Mg2+ binding site [chemical binding]; other site 316274002429 G2 box; other site 316274002430 Switch I region; other site 316274002431 G3 box; other site 316274002432 Switch II region; other site 316274002433 G4 box; other site 316274002434 G5 box; other site 316274002435 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 316274002436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 316274002437 homodimer interface [polypeptide binding]; other site 316274002438 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 316274002439 metal binding site [ion binding]; metal-binding site 316274002440 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 316274002441 homodimer interface [polypeptide binding]; other site 316274002442 active site 316274002443 putative chemical substrate binding site [chemical binding]; other site 316274002444 metal binding site [ion binding]; metal-binding site 316274002445 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 316274002446 SurA N-terminal domain; Region: SurA_N; pfam09312 316274002447 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316274002448 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 316274002449 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 316274002450 dimer interface [polypeptide binding]; other site 316274002451 active site 316274002452 glycine-pyridoxal phosphate binding site [chemical binding]; other site 316274002453 folate binding site [chemical binding]; other site 316274002454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002455 GAF domain; Region: GAF; pfam01590 316274002456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274002457 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274002458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002460 dimer interface [polypeptide binding]; other site 316274002461 phosphorylation site [posttranslational modification] 316274002462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002463 ATP binding site [chemical binding]; other site 316274002464 Mg2+ binding site [ion binding]; other site 316274002465 G-X-G motif; other site 316274002466 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002468 active site 316274002469 phosphorylation site [posttranslational modification] 316274002470 intermolecular recognition site; other site 316274002471 dimerization interface [polypeptide binding]; other site 316274002472 enoyl-CoA hydratase; Provisional; Region: PRK05995 316274002473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316274002474 substrate binding site [chemical binding]; other site 316274002475 oxyanion hole (OAH) forming residues; other site 316274002476 trimer interface [polypeptide binding]; other site 316274002477 Double zinc ribbon; Region: DZR; pfam12773 316274002478 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316274002479 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 316274002480 putative phosphate acyltransferase; Provisional; Region: PRK05331 316274002481 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 316274002482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002483 Coenzyme A binding pocket [chemical binding]; other site 316274002484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 316274002485 Sterol carrier protein domain; Region: SCP2_2; pfam13530 316274002486 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 316274002487 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 316274002488 putative sugar binding sites [chemical binding]; other site 316274002489 Q-X-W motif; other site 316274002490 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274002491 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274002492 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274002493 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316274002494 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316274002495 active site 316274002496 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 316274002497 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274002498 active site 316274002499 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274002500 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274002501 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274002502 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274002503 putative NADP binding site [chemical binding]; other site 316274002504 active site 316274002505 Family description; Region: VCBS; pfam13517 316274002506 Family description; Region: VCBS; pfam13517 316274002507 Family description; Region: VCBS; pfam13517 316274002508 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 316274002509 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 316274002510 Family description; Region: VCBS; pfam13517 316274002511 Family description; Region: VCBS; pfam13517 316274002512 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 316274002513 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 316274002514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274002515 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 316274002516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274002517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274002518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274002519 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 316274002520 putative hydrophobic ligand binding site [chemical binding]; other site 316274002521 HEAT repeats; Region: HEAT_2; pfam13646 316274002522 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 316274002523 Clp amino terminal domain; Region: Clp_N; pfam02861 316274002524 Clp amino terminal domain; Region: Clp_N; pfam02861 316274002525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274002526 Walker A motif; other site 316274002527 ATP binding site [chemical binding]; other site 316274002528 Walker B motif; other site 316274002529 arginine finger; other site 316274002530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274002531 Walker A motif; other site 316274002532 ATP binding site [chemical binding]; other site 316274002533 Walker B motif; other site 316274002534 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274002535 phosphoglyceromutase; Provisional; Region: PRK05434 316274002536 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 316274002537 GAF domain; Region: GAF; cl17456 316274002538 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 316274002539 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 316274002540 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 316274002541 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 316274002542 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 316274002543 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316274002544 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 316274002545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274002546 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 316274002547 dimerization interface [polypeptide binding]; other site 316274002548 putative active cleft [active] 316274002549 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 316274002550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274002551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274002552 Domain of unknown function (DUF377); Region: DUF377; pfam04041 316274002553 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 316274002554 active site 316274002555 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274002556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274002557 DNA binding site [nucleotide binding] 316274002558 domain linker motif; other site 316274002559 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274002560 ligand binding site [chemical binding]; other site 316274002561 dimerization interface [polypeptide binding]; other site 316274002562 lipoyl synthase; Provisional; Region: PRK05481 316274002563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274002564 FeS/SAM binding site; other site 316274002565 AIR carboxylase; Region: AIRC; pfam00731 316274002566 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 316274002567 ATP-grasp domain; Region: ATP-grasp; pfam02222 316274002568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316274002569 Double zinc ribbon; Region: DZR; pfam12773 316274002570 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316274002571 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002572 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274002573 phosphopeptide binding site; other site 316274002574 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274002575 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002576 phosphopeptide binding site; other site 316274002577 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274002578 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 316274002579 Walker A/P-loop; other site 316274002580 ATP binding site [chemical binding]; other site 316274002581 Q-loop/lid; other site 316274002582 ABC transporter signature motif; other site 316274002583 Walker B; other site 316274002584 D-loop; other site 316274002585 H-loop/switch region; other site 316274002586 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316274002587 Double zinc ribbon; Region: DZR; pfam12773 316274002588 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274002589 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274002590 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274002591 active site 316274002592 Protein kinase; unclassified specificity; Region: STYKc; smart00221 316274002593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274002594 active site 316274002595 ATP binding site [chemical binding]; other site 316274002596 substrate binding site [chemical binding]; other site 316274002597 activation loop (A-loop); other site 316274002598 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274002599 Double zinc ribbon; Region: DZR; pfam12773 316274002600 Double zinc ribbon; Region: DZR; pfam12773 316274002601 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274002602 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274002603 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274002604 phosphopeptide binding site; other site 316274002605 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 316274002606 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 316274002607 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 316274002608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274002609 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274002610 CoenzymeA binding site [chemical binding]; other site 316274002611 subunit interaction site [polypeptide binding]; other site 316274002612 PHB binding site; other site 316274002613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274002614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002615 active site 316274002616 phosphorylation site [posttranslational modification] 316274002617 intermolecular recognition site; other site 316274002618 dimerization interface [polypeptide binding]; other site 316274002619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274002620 DNA binding site [nucleotide binding] 316274002621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274002623 dimerization interface [polypeptide binding]; other site 316274002624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002625 dimer interface [polypeptide binding]; other site 316274002626 phosphorylation site [posttranslational modification] 316274002627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002628 ATP binding site [chemical binding]; other site 316274002629 Mg2+ binding site [ion binding]; other site 316274002630 G-X-G motif; other site 316274002631 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 316274002633 phosphorylation site [posttranslational modification] 316274002634 intermolecular recognition site; other site 316274002635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274002636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316274002637 Walker A/P-loop; other site 316274002638 ATP binding site [chemical binding]; other site 316274002639 Q-loop/lid; other site 316274002640 ABC transporter signature motif; other site 316274002641 Walker B; other site 316274002642 D-loop; other site 316274002643 H-loop/switch region; other site 316274002644 FtsX-like permease family; Region: FtsX; pfam02687 316274002645 AAA domain; Region: AAA_22; pfam13401 316274002646 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274002647 YcaO-like family; Region: YcaO; pfam02624 316274002648 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 316274002649 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 316274002650 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 316274002651 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 316274002652 NADPH bind site [chemical binding]; other site 316274002653 putative FMN binding site [chemical binding]; other site 316274002654 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 316274002655 putative FMN binding site [chemical binding]; other site 316274002656 NADPH bind site [chemical binding]; other site 316274002657 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 316274002658 active site 316274002659 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 316274002660 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 316274002661 SpaB C-terminal domain; Region: SpaB_C; pfam14028 316274002662 SpaB C-terminal domain; Region: SpaB_C; pfam14028 316274002663 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 316274002664 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274002665 Walker A/P-loop; other site 316274002666 ATP binding site [chemical binding]; other site 316274002667 Q-loop/lid; other site 316274002668 ABC transporter signature motif; other site 316274002669 Walker B; other site 316274002670 D-loop; other site 316274002671 H-loop/switch region; other site 316274002672 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316274002673 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 316274002674 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316274002675 homodimer interface [polypeptide binding]; other site 316274002676 substrate-cofactor binding pocket; other site 316274002677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002678 catalytic residue [active] 316274002679 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 316274002680 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 316274002681 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274002682 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 316274002683 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274002684 G1 box; other site 316274002685 GTP/Mg2+ binding site [chemical binding]; other site 316274002686 G2 box; other site 316274002687 Switch I region; other site 316274002688 G3 box; other site 316274002689 Switch II region; other site 316274002690 G4 box; other site 316274002691 G5 box; other site 316274002692 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 316274002693 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 316274002694 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002695 Kelch motif; Region: Kelch_1; pfam01344 316274002696 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002697 Kelch domain; Region: Kelch; smart00612 316274002698 Kelch motif; Region: Kelch_1; pfam01344 316274002699 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002700 Galactose oxidase, central domain; Region: Kelch_3; cl02701 316274002701 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002702 Kelch motif; Region: Kelch_1; pfam01344 316274002703 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002704 Kelch domain; Region: Kelch; smart00612 316274002705 Kelch motif; Region: Kelch_6; pfam13964 316274002706 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274002707 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316274002708 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 316274002709 putative dimer interface [polypeptide binding]; other site 316274002710 GAF domain; Region: GAF_2; pfam13185 316274002711 GAF domain; Region: GAF_3; pfam13492 316274002712 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274002713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002714 putative active site [active] 316274002715 heme pocket [chemical binding]; other site 316274002716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274002717 dimer interface [polypeptide binding]; other site 316274002718 phosphorylation site [posttranslational modification] 316274002719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002720 ATP binding site [chemical binding]; other site 316274002721 Mg2+ binding site [ion binding]; other site 316274002722 G-X-G motif; other site 316274002723 conserved repeat domain; Region: B_ant_repeat; TIGR01451 316274002724 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 316274002725 CHASE2 domain; Region: CHASE2; pfam05226 316274002726 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274002727 cyclase homology domain; Region: CHD; cd07302 316274002728 nucleotidyl binding site; other site 316274002729 metal binding site [ion binding]; metal-binding site 316274002730 dimer interface [polypeptide binding]; other site 316274002731 FecR protein; Region: FecR; pfam04773 316274002732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274002733 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274002734 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 316274002735 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 316274002736 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 316274002737 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 316274002738 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 316274002739 active site 316274002740 substrate binding site [chemical binding]; other site 316274002741 cosubstrate binding site; other site 316274002742 catalytic site [active] 316274002743 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 316274002744 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316274002745 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274002746 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316274002747 Predicted ATPase [General function prediction only]; Region: COG3903 316274002748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274002749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274002750 TPR motif; other site 316274002751 TPR repeat; Region: TPR_11; pfam13414 316274002752 binding surface 316274002753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274002755 DNA binding residues [nucleotide binding] 316274002756 dimerization interface [polypeptide binding]; other site 316274002757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274002758 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274002759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274002760 Walker A/P-loop; other site 316274002761 ATP binding site [chemical binding]; other site 316274002762 Q-loop/lid; other site 316274002763 ABC transporter signature motif; other site 316274002764 Walker B; other site 316274002765 D-loop; other site 316274002766 H-loop/switch region; other site 316274002767 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274002768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274002769 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316274002770 Walker A/P-loop; other site 316274002771 ATP binding site [chemical binding]; other site 316274002772 Q-loop/lid; other site 316274002773 ABC transporter signature motif; other site 316274002774 Walker B; other site 316274002775 D-loop; other site 316274002776 H-loop/switch region; other site 316274002777 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 316274002778 active site 316274002779 dimerization interface [polypeptide binding]; other site 316274002780 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 316274002781 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 316274002782 threonine dehydratase; Provisional; Region: PRK08198 316274002783 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 316274002784 tetramer interface [polypeptide binding]; other site 316274002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274002786 catalytic residue [active] 316274002787 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 316274002788 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274002789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002790 Coenzyme A binding pocket [chemical binding]; other site 316274002791 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 316274002792 hydrophobic ligand binding site; other site 316274002793 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 316274002794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274002795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274002796 DNA binding residues [nucleotide binding] 316274002797 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 316274002798 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274002799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274002800 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 316274002801 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274002802 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274002803 active site 316274002804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274002805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274002806 active site 316274002807 SCP-2 sterol transfer family; Region: SCP2; pfam02036 316274002808 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274002809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274002810 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 316274002811 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316274002812 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316274002813 active site 316274002814 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316274002815 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316274002816 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 316274002817 Response regulator receiver domain; Region: Response_reg; pfam00072 316274002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002819 active site 316274002820 phosphorylation site [posttranslational modification] 316274002821 intermolecular recognition site; other site 316274002822 dimerization interface [polypeptide binding]; other site 316274002823 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 316274002824 active site 316274002825 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274002826 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274002827 Stage II sporulation protein; Region: SpoIID; pfam08486 316274002828 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274002829 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274002830 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274002831 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 316274002832 Translin family; Region: Translin; cl00957 316274002833 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 316274002834 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 316274002835 hinge; other site 316274002836 active site 316274002837 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 316274002838 short chain dehydrogenase; Provisional; Region: PRK07677 316274002839 NAD(P) binding site [chemical binding]; other site 316274002840 substrate binding site [chemical binding]; other site 316274002841 homotetramer interface [polypeptide binding]; other site 316274002842 active site 316274002843 homodimer interface [polypeptide binding]; other site 316274002844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002846 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274002847 Cytochrome P450; Region: p450; cl12078 316274002848 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 316274002849 classical (c) SDRs; Region: SDR_c; cd05233 316274002850 NAD(P) binding site [chemical binding]; other site 316274002851 active site 316274002852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274002853 dimerization interface [polypeptide binding]; other site 316274002854 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274002855 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274002856 OsmC-like protein; Region: OsmC; pfam02566 316274002857 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274002858 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274002859 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274002860 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316274002861 active site 316274002862 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 316274002863 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 316274002864 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 316274002865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274002866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274002867 dimerization interface [polypeptide binding]; other site 316274002868 Histidine kinase; Region: HisKA_3; pfam07730 316274002869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002870 ATP binding site [chemical binding]; other site 316274002871 Mg2+ binding site [ion binding]; other site 316274002872 G-X-G motif; other site 316274002873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002875 active site 316274002876 phosphorylation site [posttranslational modification] 316274002877 intermolecular recognition site; other site 316274002878 dimerization interface [polypeptide binding]; other site 316274002879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274002880 DNA binding residues [nucleotide binding] 316274002881 dimerization interface [polypeptide binding]; other site 316274002882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002883 metabolite-proton symporter; Region: 2A0106; TIGR00883 316274002884 putative substrate translocation pore; other site 316274002885 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274002887 active site 316274002888 phosphorylation site [posttranslational modification] 316274002889 intermolecular recognition site; other site 316274002890 dimerization interface [polypeptide binding]; other site 316274002891 PAS fold; Region: PAS; pfam00989 316274002892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002893 putative active site [active] 316274002894 heme pocket [chemical binding]; other site 316274002895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274002896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274002897 metal binding site [ion binding]; metal-binding site 316274002898 active site 316274002899 I-site; other site 316274002900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274002901 GAF domain; Region: GAF; cl17456 316274002902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274002903 PAS domain; Region: PAS_9; pfam13426 316274002904 putative active site [active] 316274002905 heme pocket [chemical binding]; other site 316274002906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274002907 Histidine kinase; Region: HisKA_2; pfam07568 316274002908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274002909 ATP binding site [chemical binding]; other site 316274002910 Mg2+ binding site [ion binding]; other site 316274002911 G-X-G motif; other site 316274002912 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274002913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316274002914 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316274002915 Double zinc ribbon; Region: DZR; pfam12773 316274002916 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274002917 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274002918 active site 316274002919 ATP binding site [chemical binding]; other site 316274002920 substrate binding site [chemical binding]; other site 316274002921 activation loop (A-loop); other site 316274002922 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274002923 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 316274002924 putative diguanylate cyclase; Provisional; Region: PRK09776 316274002925 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 316274002926 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 316274002927 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 316274002928 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274002929 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 316274002930 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 316274002931 acetyl-CoA synthetase; Provisional; Region: PRK00174 316274002932 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 316274002933 active site 316274002934 CoA binding site [chemical binding]; other site 316274002935 acyl-activating enzyme (AAE) consensus motif; other site 316274002936 AMP binding site [chemical binding]; other site 316274002937 acetate binding site [chemical binding]; other site 316274002938 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 316274002939 HemN C-terminal domain; Region: HemN_C; pfam06969 316274002940 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274002941 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274002942 putative active site [active] 316274002943 putative metal binding site [ion binding]; other site 316274002944 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316274002945 active site 316274002946 catalytic site [active] 316274002947 substrate binding site [chemical binding]; other site 316274002948 WYL domain; Region: WYL; pfam13280 316274002949 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 316274002950 putative deacylase active site [active] 316274002951 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274002952 Switch II region; other site 316274002953 G4 box; other site 316274002954 G5 box; other site 316274002955 CHAP domain; Region: CHAP; cl17642 316274002956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274002958 DNA binding residues [nucleotide binding] 316274002959 dimerization interface [polypeptide binding]; other site 316274002960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274002961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274002962 DNA binding residues [nucleotide binding] 316274002963 dimerization interface [polypeptide binding]; other site 316274002964 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274002965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274002966 non-specific DNA binding site [nucleotide binding]; other site 316274002967 salt bridge; other site 316274002968 sequence-specific DNA binding site [nucleotide binding]; other site 316274002969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274002970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002971 Coenzyme A binding pocket [chemical binding]; other site 316274002972 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316274002973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274002974 Coenzyme A binding pocket [chemical binding]; other site 316274002975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274002976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274002977 non-specific DNA binding site [nucleotide binding]; other site 316274002978 salt bridge; other site 316274002979 sequence-specific DNA binding site [nucleotide binding]; other site 316274002980 Domain of unknown function (DUF955); Region: DUF955; pfam06114 316274002981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274002982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274002983 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 316274002984 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274002986 putative substrate translocation pore; other site 316274002987 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 316274002988 malate synthase A; Region: malate_syn_A; TIGR01344 316274002989 active site 316274002990 isocitrate lyase; Provisional; Region: PRK15063 316274002991 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 316274002992 tetramer interface [polypeptide binding]; other site 316274002993 active site 316274002994 Mg2+/Mn2+ binding site [ion binding]; other site 316274002995 shikimate kinase; Reviewed; Region: aroK; PRK00131 316274002996 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 316274002997 ADP binding site [chemical binding]; other site 316274002998 magnesium binding site [ion binding]; other site 316274002999 putative shikimate binding site; other site 316274003000 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 316274003001 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 316274003002 metal binding site [ion binding]; metal-binding site 316274003003 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316274003004 Phosphotransferase enzyme family; Region: APH; pfam01636 316274003005 active site 316274003006 ATP binding site [chemical binding]; other site 316274003007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316274003008 substrate binding site [chemical binding]; other site 316274003009 phosphodiesterase YaeI; Provisional; Region: PRK11340 316274003010 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274003011 putative active site [active] 316274003012 putative metal binding site [ion binding]; other site 316274003013 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 316274003014 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 316274003015 Cl- selectivity filter; other site 316274003016 Cl- binding residues [ion binding]; other site 316274003017 pore gating glutamate residue; other site 316274003018 dimer interface [polypeptide binding]; other site 316274003019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274003020 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 316274003021 putative ADP-binding pocket [chemical binding]; other site 316274003022 Methyltransferase domain; Region: Methyltransf_24; pfam13578 316274003023 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316274003024 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274003025 putative ribose interaction site [chemical binding]; other site 316274003026 putative ADP binding site [chemical binding]; other site 316274003027 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316274003028 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316274003029 putative active site [active] 316274003030 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274003031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274003032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274003033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274003034 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316274003035 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 316274003036 Walker A/P-loop; other site 316274003037 ATP binding site [chemical binding]; other site 316274003038 Q-loop/lid; other site 316274003039 ABC transporter signature motif; other site 316274003040 Walker B; other site 316274003041 D-loop; other site 316274003042 H-loop/switch region; other site 316274003043 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 316274003044 putative carbohydrate binding site [chemical binding]; other site 316274003045 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 316274003046 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274003047 Uncharacterized conserved protein [Function unknown]; Region: COG2968 316274003048 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 316274003049 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 316274003050 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 316274003051 tetramer interface [polypeptide binding]; other site 316274003052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003053 catalytic residue [active] 316274003054 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274003055 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 316274003056 active site 316274003057 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 316274003058 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 316274003059 dimer interface [polypeptide binding]; other site 316274003060 active site 316274003061 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274003062 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316274003063 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 316274003064 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 316274003065 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 316274003066 catalytic residues [active] 316274003067 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 316274003068 ATP-NAD kinase; Region: NAD_kinase; pfam01513 316274003069 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 316274003070 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 316274003071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274003072 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316274003073 catalytic site [active] 316274003074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274003075 TPR repeat; Region: TPR_11; pfam13414 316274003076 binding surface 316274003077 TPR motif; other site 316274003078 CAAX protease self-immunity; Region: Abi; pfam02517 316274003079 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 316274003080 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316274003081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274003082 FeS/SAM binding site; other site 316274003083 TRAM domain; Region: TRAM; pfam01938 316274003084 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003086 active site 316274003087 phosphorylation site [posttranslational modification] 316274003088 intermolecular recognition site; other site 316274003089 dimerization interface [polypeptide binding]; other site 316274003090 cobyric acid synthase; Provisional; Region: PRK00784 316274003091 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 316274003092 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316274003093 catalytic triad [active] 316274003094 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 316274003095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274003096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003097 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274003098 catalytic residue [active] 316274003099 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 316274003100 homotrimer interface [polypeptide binding]; other site 316274003101 Walker A motif; other site 316274003102 GTP binding site [chemical binding]; other site 316274003103 Walker B motif; other site 316274003104 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274003105 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274003106 Walker A/P-loop; other site 316274003107 ATP binding site [chemical binding]; other site 316274003108 Q-loop/lid; other site 316274003109 ABC transporter signature motif; other site 316274003110 Walker B; other site 316274003111 D-loop; other site 316274003112 H-loop/switch region; other site 316274003113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274003114 ABC-ATPase subunit interface; other site 316274003115 dimer interface [polypeptide binding]; other site 316274003116 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316274003117 putative PBP binding regions; other site 316274003118 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316274003119 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 316274003120 cobalamin binding residues [chemical binding]; other site 316274003121 putative BtuC binding residues; other site 316274003122 dimer interface [polypeptide binding]; other site 316274003123 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 316274003124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274003125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274003126 S-adenosylmethionine binding site [chemical binding]; other site 316274003127 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 316274003128 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 316274003129 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 316274003130 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 316274003131 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 316274003132 dimer interface [polypeptide binding]; other site 316274003133 [2Fe-2S] cluster binding site [ion binding]; other site 316274003134 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 316274003135 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 316274003136 homodimer interface [polypeptide binding]; other site 316274003137 Walker A motif; other site 316274003138 ATP binding site [chemical binding]; other site 316274003139 hydroxycobalamin binding site [chemical binding]; other site 316274003140 Walker B motif; other site 316274003141 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274003142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274003143 Walker A/P-loop; other site 316274003144 ATP binding site [chemical binding]; other site 316274003145 Q-loop/lid; other site 316274003146 ABC transporter signature motif; other site 316274003147 Walker B; other site 316274003148 D-loop; other site 316274003149 H-loop/switch region; other site 316274003150 TOBE domain; Region: TOBE_2; pfam08402 316274003151 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274003152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003153 dimer interface [polypeptide binding]; other site 316274003154 conserved gate region; other site 316274003155 putative PBP binding loops; other site 316274003156 ABC-ATPase subunit interface; other site 316274003157 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274003158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003159 dimer interface [polypeptide binding]; other site 316274003160 conserved gate region; other site 316274003161 putative PBP binding loops; other site 316274003162 ABC-ATPase subunit interface; other site 316274003163 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 316274003164 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 316274003165 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 316274003166 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 316274003167 active site 316274003168 nucleotide binding site [chemical binding]; other site 316274003169 HIGH motif; other site 316274003170 KMSKS motif; other site 316274003171 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 316274003172 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316274003173 putative ribose interaction site [chemical binding]; other site 316274003174 putative ADP binding site [chemical binding]; other site 316274003175 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316274003176 classical (c) SDRs; Region: SDR_c; cd05233 316274003177 NAD(P) binding site [chemical binding]; other site 316274003178 active site 316274003179 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 316274003180 active site 316274003181 catalytic residues [active] 316274003182 Sugar fermentation stimulation protein; Region: SfsA; cl00647 316274003183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274003184 dimerization interface [polypeptide binding]; other site 316274003185 putative DNA binding site [nucleotide binding]; other site 316274003186 putative Zn2+ binding site [ion binding]; other site 316274003187 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 316274003188 putative hydrophobic ligand binding site [chemical binding]; other site 316274003189 DoxX-like family; Region: DoxX_2; pfam13564 316274003190 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 316274003191 PSP1 C-terminal conserved region; Region: PSP1; cl00770 316274003192 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274003193 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274003194 phosphopeptide binding site; other site 316274003195 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003196 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274003197 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316274003198 cyclase homology domain; Region: CHD; cd07302 316274003199 nucleotidyl binding site; other site 316274003200 metal binding site [ion binding]; metal-binding site 316274003201 dimer interface [polypeptide binding]; other site 316274003202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274003203 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274003204 nucleotide binding site [chemical binding]; other site 316274003205 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 316274003206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274003207 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 316274003208 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 316274003209 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 316274003210 Predicted membrane protein [Function unknown]; Region: COG2733 316274003211 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 316274003213 active site 316274003214 phosphorylation site [posttranslational modification] 316274003215 intermolecular recognition site; other site 316274003216 dimerization interface [polypeptide binding]; other site 316274003217 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274003218 Ligand Binding Site [chemical binding]; other site 316274003219 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316274003220 Ligand Binding Site [chemical binding]; other site 316274003221 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 316274003222 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 316274003223 ligand binding site [chemical binding]; other site 316274003224 NAD binding site [chemical binding]; other site 316274003225 dimerization interface [polypeptide binding]; other site 316274003226 catalytic site [active] 316274003227 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 316274003228 putative L-serine binding site [chemical binding]; other site 316274003229 yiaA/B two helix domain; Region: YiaAB; cl01759 316274003230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274003231 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 316274003232 NAD(P) binding site [chemical binding]; other site 316274003233 active site 316274003234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274003235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274003236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274003237 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316274003238 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 316274003239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274003240 S-adenosylmethionine binding site [chemical binding]; other site 316274003241 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 316274003242 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 316274003243 Lamin Tail Domain; Region: LTD; pfam00932 316274003244 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 316274003245 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003247 active site 316274003248 phosphorylation site [posttranslational modification] 316274003249 intermolecular recognition site; other site 316274003250 dimerization interface [polypeptide binding]; other site 316274003251 CHASE4 domain; Region: CHASE4; pfam05228 316274003252 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274003254 dimerization interface [polypeptide binding]; other site 316274003255 putative DNA binding site [nucleotide binding]; other site 316274003256 putative Zn2+ binding site [ion binding]; other site 316274003257 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 316274003258 homoserine dehydrogenase family protein; Region: PLN02700 316274003259 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 316274003260 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274003261 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274003262 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 316274003263 Walker A/P-loop; other site 316274003264 ATP binding site [chemical binding]; other site 316274003265 Q-loop/lid; other site 316274003266 ABC transporter signature motif; other site 316274003267 Walker B; other site 316274003268 D-loop; other site 316274003269 H-loop/switch region; other site 316274003270 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274003271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003272 active site 316274003273 phosphorylation site [posttranslational modification] 316274003274 intermolecular recognition site; other site 316274003275 dimerization interface [polypeptide binding]; other site 316274003276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274003277 DNA binding residues [nucleotide binding] 316274003278 dimerization interface [polypeptide binding]; other site 316274003279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274003280 dimerization interface [polypeptide binding]; other site 316274003281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274003282 Histidine kinase; Region: HisKA_3; pfam07730 316274003283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003284 ATP binding site [chemical binding]; other site 316274003285 Mg2+ binding site [ion binding]; other site 316274003286 G-X-G motif; other site 316274003287 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316274003288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274003289 FeS/SAM binding site; other site 316274003290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003291 putative active site [active] 316274003292 heme pocket [chemical binding]; other site 316274003293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274003294 metal binding site [ion binding]; metal-binding site 316274003295 active site 316274003296 I-site; other site 316274003297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316274003298 PspC domain; Region: PspC; pfam04024 316274003299 CHAP domain; Region: CHAP; cl17642 316274003300 AAA ATPase domain; Region: AAA_16; pfam13191 316274003301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274003302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274003303 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274003304 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274003305 active site 316274003306 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 316274003307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316274003308 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 316274003309 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274003310 metal ion-dependent adhesion site (MIDAS); other site 316274003311 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 316274003312 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 316274003313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274003314 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274003315 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274003316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274003317 S-adenosylmethionine binding site [chemical binding]; other site 316274003318 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274003319 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 316274003320 G1 box; other site 316274003321 putative GEF interaction site [polypeptide binding]; other site 316274003322 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 316274003323 GTP/Mg2+ binding site [chemical binding]; other site 316274003324 Switch I region; other site 316274003325 G2 box; other site 316274003326 G3 box; other site 316274003327 Switch II region; other site 316274003328 G4 box; other site 316274003329 G5 box; other site 316274003330 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 316274003331 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 316274003332 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 316274003333 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 316274003334 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 316274003335 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 316274003336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274003337 binding surface 316274003338 TPR motif; other site 316274003339 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316274003340 DNA methylase; Region: N6_N4_Mtase; cl17433 316274003341 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 316274003342 TIGR03085 family protein; Region: TIGR03085 316274003343 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274003344 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274003345 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316274003346 active site 316274003347 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316274003348 active site 316274003349 lipoprotein signal peptidase; Provisional; Region: PRK14787 316274003350 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 316274003351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274003352 binding surface 316274003353 TPR motif; other site 316274003354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274003355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274003356 metal binding site [ion binding]; metal-binding site 316274003357 active site 316274003358 I-site; other site 316274003359 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274003360 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274003361 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274003362 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 316274003363 active site 316274003364 substrate binding site [chemical binding]; other site 316274003365 Mg2+ binding site [ion binding]; other site 316274003366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003367 putative substrate translocation pore; other site 316274003368 sugar efflux transporter; Region: 2A0120; TIGR00899 316274003369 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 316274003370 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 316274003371 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 316274003372 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316274003373 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316274003374 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003375 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003377 putative active site [active] 316274003378 heme pocket [chemical binding]; other site 316274003379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274003380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274003381 dimer interface [polypeptide binding]; other site 316274003382 phosphorylation site [posttranslational modification] 316274003383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003384 ATP binding site [chemical binding]; other site 316274003385 Mg2+ binding site [ion binding]; other site 316274003386 G-X-G motif; other site 316274003387 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 316274003388 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316274003389 active site 316274003390 nucleophile elbow; other site 316274003391 AAA ATPase domain; Region: AAA_16; pfam13191 316274003392 Predicted ATPase [General function prediction only]; Region: COG3903 316274003393 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274003394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274003395 binding surface 316274003396 TPR motif; other site 316274003397 TROVE domain; Region: TROVE; pfam05731 316274003398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274003399 metal ion-dependent adhesion site (MIDAS); other site 316274003400 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 316274003401 putative homodimer interface [polypeptide binding]; other site 316274003402 putative active site pocket [active] 316274003403 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 316274003404 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274003405 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003407 dimer interface [polypeptide binding]; other site 316274003408 conserved gate region; other site 316274003409 putative PBP binding loops; other site 316274003410 ABC-ATPase subunit interface; other site 316274003411 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274003412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003413 dimer interface [polypeptide binding]; other site 316274003414 conserved gate region; other site 316274003415 putative PBP binding loops; other site 316274003416 ABC-ATPase subunit interface; other site 316274003417 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 316274003418 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274003419 active site 316274003420 catalytic site [active] 316274003421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003422 Coenzyme A binding pocket [chemical binding]; other site 316274003423 BioY family; Region: BioY; pfam02632 316274003424 Protein of unknown function (DUF779); Region: DUF779; pfam05610 316274003425 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 316274003426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274003427 NAD(P) binding site [chemical binding]; other site 316274003428 catalytic residues [active] 316274003429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003430 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003431 active site 316274003432 phosphorylation site [posttranslational modification] 316274003433 intermolecular recognition site; other site 316274003434 dimerization interface [polypeptide binding]; other site 316274003435 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 316274003436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274003437 phosphorylation site [posttranslational modification] 316274003438 dimer interface [polypeptide binding]; other site 316274003439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003440 ATP binding site [chemical binding]; other site 316274003441 Mg2+ binding site [ion binding]; other site 316274003442 G-X-G motif; other site 316274003443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274003444 TPR motif; other site 316274003445 binding surface 316274003446 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274003447 Glyco_18 domain; Region: Glyco_18; smart00636 316274003448 active site 316274003449 hypothetical protein; Provisional; Region: PRK10621 316274003450 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316274003451 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316274003452 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316274003453 active site 316274003454 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 316274003455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274003456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274003457 active site 316274003458 catalytic tetrad [active] 316274003459 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 316274003460 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316274003461 dimer interface [polypeptide binding]; other site 316274003462 active site 316274003463 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316274003464 dimer interface [polypeptide binding]; other site 316274003465 active site 316274003466 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 316274003467 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 316274003468 active site 316274003469 dimer interface [polypeptide binding]; other site 316274003470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003471 Coenzyme A binding pocket [chemical binding]; other site 316274003472 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 316274003473 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 316274003474 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 316274003475 putative active site [active] 316274003476 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274003477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003478 dimer interface [polypeptide binding]; other site 316274003479 conserved gate region; other site 316274003480 putative PBP binding loops; other site 316274003481 ABC-ATPase subunit interface; other site 316274003482 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316274003483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003484 dimer interface [polypeptide binding]; other site 316274003485 conserved gate region; other site 316274003486 putative PBP binding loops; other site 316274003487 ABC-ATPase subunit interface; other site 316274003488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274003489 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 316274003490 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274003491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274003492 nucleotide binding site [chemical binding]; other site 316274003493 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274003494 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274003495 nucleotide binding site [chemical binding]; other site 316274003496 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 316274003497 putative active site [active] 316274003498 Zn binding site [ion binding]; other site 316274003499 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 316274003500 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274003501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003502 Coenzyme A binding pocket [chemical binding]; other site 316274003503 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274003504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274003505 active site 316274003506 metal binding site [ion binding]; metal-binding site 316274003507 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274003508 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 316274003509 active site 316274003510 catalytic triad [active] 316274003511 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274003512 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274003513 phosphopeptide binding site; other site 316274003514 Protein of unknown function (DUF456); Region: DUF456; pfam04306 316274003515 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 316274003516 Amino acid permease; Region: AA_permease_2; pfam13520 316274003517 Cna protein B-type domain; Region: Cna_B_2; pfam13715 316274003518 Cna protein B-type domain; Region: Cna_B_2; pfam13715 316274003519 Cna protein B-type domain; Region: Cna_B_2; pfam13715 316274003520 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 316274003521 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 316274003522 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 316274003523 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 316274003524 DNA binding site [nucleotide binding] 316274003525 catalytic residue [active] 316274003526 H2TH interface [polypeptide binding]; other site 316274003527 putative catalytic residues [active] 316274003528 turnover-facilitating residue; other site 316274003529 intercalation triad [nucleotide binding]; other site 316274003530 8OG recognition residue [nucleotide binding]; other site 316274003531 putative reading head residues; other site 316274003532 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316274003533 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316274003534 UGMP family protein; Validated; Region: PRK09604 316274003535 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 316274003536 Esterase/lipase [General function prediction only]; Region: COG1647 316274003537 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 316274003538 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 316274003539 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274003540 putative active site [active] 316274003541 putative metal binding site [ion binding]; other site 316274003542 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 316274003543 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 316274003544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 316274003545 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 316274003546 active site 316274003547 DinB superfamily; Region: DinB_2; pfam12867 316274003548 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 316274003549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316274003550 substrate binding site [chemical binding]; other site 316274003551 oxyanion hole (OAH) forming residues; other site 316274003552 trimer interface [polypeptide binding]; other site 316274003553 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 316274003554 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 316274003555 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316274003556 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274003557 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 316274003558 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274003559 Predicted transcriptional regulator [Transcription]; Region: COG1959 316274003560 Transcriptional regulator; Region: Rrf2; pfam02082 316274003561 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 316274003562 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 316274003563 putative NADP binding site [chemical binding]; other site 316274003564 putative substrate binding site [chemical binding]; other site 316274003565 active site 316274003566 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 316274003567 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 316274003568 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274003569 CHAT domain; Region: CHAT; pfam12770 316274003570 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316274003571 GTP binding site; other site 316274003572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274003573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274003574 Protein of unknown function (DUF422); Region: DUF422; pfam04240 316274003575 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274003576 cyclase homology domain; Region: CHD; cd07302 316274003577 nucleotidyl binding site; other site 316274003578 metal binding site [ion binding]; metal-binding site 316274003579 dimer interface [polypeptide binding]; other site 316274003580 cyclase homology domain; Region: CHD; cd07302 316274003581 nucleotidyl binding site; other site 316274003582 metal binding site [ion binding]; metal-binding site 316274003583 dimer interface [polypeptide binding]; other site 316274003584 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274003585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274003586 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003588 active site 316274003589 phosphorylation site [posttranslational modification] 316274003590 intermolecular recognition site; other site 316274003591 dimerization interface [polypeptide binding]; other site 316274003592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274003593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003594 Coenzyme A binding pocket [chemical binding]; other site 316274003595 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316274003596 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316274003597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274003598 dimerization interface [polypeptide binding]; other site 316274003599 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003600 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274003601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003602 PAS domain; Region: PAS_9; pfam13426 316274003603 putative active site [active] 316274003604 heme pocket [chemical binding]; other site 316274003605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274003606 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003607 putative active site [active] 316274003608 heme pocket [chemical binding]; other site 316274003609 PAS domain; Region: PAS; smart00091 316274003610 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274003611 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274003612 PAS domain S-box; Region: sensory_box; TIGR00229 316274003613 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003614 GAF domain; Region: GAF; pfam01590 316274003615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274003616 dimer interface [polypeptide binding]; other site 316274003617 phosphorylation site [posttranslational modification] 316274003618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003619 ATP binding site [chemical binding]; other site 316274003620 Mg2+ binding site [ion binding]; other site 316274003621 G-X-G motif; other site 316274003622 threonine synthase; Validated; Region: PRK06260 316274003623 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 316274003624 homodimer interface [polypeptide binding]; other site 316274003625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003626 catalytic residue [active] 316274003627 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003629 active site 316274003630 phosphorylation site [posttranslational modification] 316274003631 intermolecular recognition site; other site 316274003632 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003634 active site 316274003635 phosphorylation site [posttranslational modification] 316274003636 intermolecular recognition site; other site 316274003637 dimerization interface [polypeptide binding]; other site 316274003638 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003640 active site 316274003641 phosphorylation site [posttranslational modification] 316274003642 intermolecular recognition site; other site 316274003643 dimerization interface [polypeptide binding]; other site 316274003644 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274003645 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 316274003646 active site 316274003647 Substrate binding site; other site 316274003648 Mg++ binding site; other site 316274003649 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274003650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274003651 Walker A motif; other site 316274003652 ATP binding site [chemical binding]; other site 316274003653 Walker B motif; other site 316274003654 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274003655 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274003656 peptide binding site [polypeptide binding]; other site 316274003657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274003658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003659 dimer interface [polypeptide binding]; other site 316274003660 conserved gate region; other site 316274003661 putative PBP binding loops; other site 316274003662 ABC-ATPase subunit interface; other site 316274003663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274003664 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274003665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003666 dimer interface [polypeptide binding]; other site 316274003667 conserved gate region; other site 316274003668 putative PBP binding loops; other site 316274003669 ABC-ATPase subunit interface; other site 316274003670 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274003671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274003672 Walker A/P-loop; other site 316274003673 ATP binding site [chemical binding]; other site 316274003674 Q-loop/lid; other site 316274003675 ABC transporter signature motif; other site 316274003676 Walker B; other site 316274003677 D-loop; other site 316274003678 H-loop/switch region; other site 316274003679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274003680 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 316274003681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274003682 Walker A/P-loop; other site 316274003683 ATP binding site [chemical binding]; other site 316274003684 Q-loop/lid; other site 316274003685 ABC transporter signature motif; other site 316274003686 Walker B; other site 316274003687 D-loop; other site 316274003688 H-loop/switch region; other site 316274003689 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316274003690 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 316274003691 dimerization interface [polypeptide binding]; other site 316274003692 putative ATP binding site [chemical binding]; other site 316274003693 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 316274003694 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316274003695 Arginase family; Region: Arginase; cd09989 316274003696 agmatinase; Region: agmatinase; TIGR01230 316274003697 active site 316274003698 Mn binding site [ion binding]; other site 316274003699 oligomer interface [polypeptide binding]; other site 316274003700 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 316274003701 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003702 Bacterial Ig-like domain; Region: Big_5; pfam13205 316274003703 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 316274003704 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003705 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316274003706 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316274003707 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316274003708 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274003709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274003710 Walker A/P-loop; other site 316274003711 ATP binding site [chemical binding]; other site 316274003712 Q-loop/lid; other site 316274003713 ABC transporter signature motif; other site 316274003714 Walker B; other site 316274003715 D-loop; other site 316274003716 H-loop/switch region; other site 316274003717 TOBE domain; Region: TOBE_2; pfam08402 316274003718 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274003719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003720 dimer interface [polypeptide binding]; other site 316274003721 conserved gate region; other site 316274003722 putative PBP binding loops; other site 316274003723 ABC-ATPase subunit interface; other site 316274003724 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274003725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003726 dimer interface [polypeptide binding]; other site 316274003727 conserved gate region; other site 316274003728 putative PBP binding loops; other site 316274003729 ABC-ATPase subunit interface; other site 316274003730 hypothetical protein; Provisional; Region: PRK11622 316274003731 Uncharacterized conserved protein [Function unknown]; Region: COG0398 316274003732 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316274003733 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 316274003734 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 316274003735 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316274003736 NAD binding site [chemical binding]; other site 316274003737 substrate binding site [chemical binding]; other site 316274003738 homodimer interface [polypeptide binding]; other site 316274003739 active site 316274003740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316274003741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274003742 DNA-binding site [nucleotide binding]; DNA binding site 316274003743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274003744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274003745 homodimer interface [polypeptide binding]; other site 316274003746 catalytic residue [active] 316274003747 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274003748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274003749 catalytic residue [active] 316274003750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274003751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274003752 DNA binding site [nucleotide binding] 316274003753 domain linker motif; other site 316274003754 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274003755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274003756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274003757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003758 dimer interface [polypeptide binding]; other site 316274003759 conserved gate region; other site 316274003760 putative PBP binding loops; other site 316274003761 ABC-ATPase subunit interface; other site 316274003762 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274003764 dimer interface [polypeptide binding]; other site 316274003765 conserved gate region; other site 316274003766 putative PBP binding loops; other site 316274003767 ABC-ATPase subunit interface; other site 316274003768 putative alpha-glucosidase; Provisional; Region: PRK10658 316274003769 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 316274003770 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 316274003771 active site 316274003772 homotrimer interface [polypeptide binding]; other site 316274003773 catalytic site [active] 316274003774 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 316274003775 xylose isomerase; Provisional; Region: PRK12677 316274003776 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 316274003777 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274003778 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274003779 active site 316274003780 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316274003781 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 316274003782 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 316274003783 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274003784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274003785 putative substrate translocation pore; other site 316274003786 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 316274003787 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 316274003788 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 316274003789 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 316274003790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274003791 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274003792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274003793 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274003794 TLC ATP/ADP transporter; Region: TLC; cl03940 316274003795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003796 Coenzyme A binding pocket [chemical binding]; other site 316274003797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274003798 dimerization interface [polypeptide binding]; other site 316274003799 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274003800 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316274003801 catalytic site [active] 316274003802 hypothetical protein; Provisional; Region: PRK07758 316274003803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 316274003804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274003805 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 316274003806 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 316274003807 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 316274003808 Na(+)-translocating NADH-quinone reductase subunit A (NQRA); Region: NQRA; pfam05896 316274003809 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003811 active site 316274003812 phosphorylation site [posttranslational modification] 316274003813 intermolecular recognition site; other site 316274003814 dimerization interface [polypeptide binding]; other site 316274003815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274003816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274003817 dimer interface [polypeptide binding]; other site 316274003818 phosphorylation site [posttranslational modification] 316274003819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003820 ATP binding site [chemical binding]; other site 316274003821 Mg2+ binding site [ion binding]; other site 316274003822 G-X-G motif; other site 316274003823 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003825 active site 316274003826 phosphorylation site [posttranslational modification] 316274003827 intermolecular recognition site; other site 316274003828 Uncharacterized conserved protein [Function unknown]; Region: COG3287 316274003829 FIST N domain; Region: FIST; pfam08495 316274003830 FIST C domain; Region: FIST_C; pfam10442 316274003831 GAF domain; Region: GAF_2; pfam13185 316274003832 GAF domain; Region: GAF_3; pfam13492 316274003833 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003834 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274003835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003836 active site 316274003837 phosphorylation site [posttranslational modification] 316274003838 intermolecular recognition site; other site 316274003839 dimerization interface [polypeptide binding]; other site 316274003840 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274003841 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 316274003842 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 316274003843 active site 316274003844 DNA binding site [nucleotide binding] 316274003845 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274003846 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 316274003847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274003848 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274003849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274003850 DNA binding residues [nucleotide binding] 316274003851 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 316274003852 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 316274003853 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 316274003854 active site 316274003855 catalytic site [active] 316274003856 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 316274003857 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274003858 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 316274003859 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274003860 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316274003861 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 316274003862 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274003863 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 316274003864 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274003865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274003866 ATP binding site [chemical binding]; other site 316274003867 putative Mg++ binding site [ion binding]; other site 316274003868 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 316274003869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274003870 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274003871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274003872 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 316274003873 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 316274003874 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274003875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274003876 non-specific DNA binding site [nucleotide binding]; other site 316274003877 salt bridge; other site 316274003878 sequence-specific DNA binding site [nucleotide binding]; other site 316274003879 quinolinate synthetase; Provisional; Region: PRK09375 316274003880 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274003881 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 316274003882 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 316274003883 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 316274003884 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 316274003885 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 316274003886 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316274003887 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274003888 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274003889 ligand binding site [chemical binding]; other site 316274003890 flexible hinge region; other site 316274003891 Cupin domain; Region: Cupin_2; cl17218 316274003892 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274003893 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274003894 catalytic site [active] 316274003895 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274003896 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274003897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274003898 ATP binding site [chemical binding]; other site 316274003899 putative Mg++ binding site [ion binding]; other site 316274003900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274003901 nucleotide binding region [chemical binding]; other site 316274003902 ATP-binding site [chemical binding]; other site 316274003903 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 316274003904 Lumazine binding domain; Region: Lum_binding; pfam00677 316274003905 Lumazine binding domain; Region: Lum_binding; pfam00677 316274003906 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316274003907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274003908 S-adenosylmethionine binding site [chemical binding]; other site 316274003909 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 316274003910 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 316274003911 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 316274003912 dimerization interface [polypeptide binding]; other site 316274003913 active site 316274003914 hypothetical protein; Reviewed; Region: PRK00024 316274003915 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316274003916 MPN+ (JAMM) motif; other site 316274003917 Zinc-binding site [ion binding]; other site 316274003918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274003919 GAF domain; Region: GAF_3; pfam13492 316274003920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274003921 Histidine kinase; Region: HisKA_3; pfam07730 316274003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274003923 ATP binding site [chemical binding]; other site 316274003924 Mg2+ binding site [ion binding]; other site 316274003925 G-X-G motif; other site 316274003926 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274003927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003928 active site 316274003929 phosphorylation site [posttranslational modification] 316274003930 intermolecular recognition site; other site 316274003931 dimerization interface [polypeptide binding]; other site 316274003932 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274003933 DNA binding residues [nucleotide binding] 316274003934 dimerization interface [polypeptide binding]; other site 316274003935 Uncharacterized conserved protein [Function unknown]; Region: COG1739 316274003936 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 316274003937 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 316274003938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274003939 Coenzyme A binding pocket [chemical binding]; other site 316274003940 Lamin Tail Domain; Region: LTD; pfam00932 316274003941 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 316274003942 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 316274003943 trimer interface [polypeptide binding]; other site 316274003944 active site 316274003945 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003947 active site 316274003948 phosphorylation site [posttranslational modification] 316274003949 intermolecular recognition site; other site 316274003950 dimerization interface [polypeptide binding]; other site 316274003951 Helix-turn-helix domain; Region: HTH_25; pfam13413 316274003952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274003953 PAS domain; Region: PAS_9; pfam13426 316274003954 putative active site [active] 316274003955 heme pocket [chemical binding]; other site 316274003956 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003957 PAS domain; Region: PAS_9; pfam13426 316274003958 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274003959 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274003961 S-adenosylmethionine binding site [chemical binding]; other site 316274003962 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 316274003963 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274003964 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274003965 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274003966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274003967 DNA binding residues [nucleotide binding] 316274003968 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 316274003969 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 316274003970 amidase catalytic site [active] 316274003971 Zn binding residues [ion binding]; other site 316274003972 substrate binding site [chemical binding]; other site 316274003973 Holin family; Region: Phage_holin_4; pfam05105 316274003974 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274003975 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316274003976 cofactor binding site; other site 316274003977 DNA binding site [nucleotide binding] 316274003978 substrate interaction site [chemical binding]; other site 316274003979 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274003980 Z1 domain; Region: Z1; pfam10593 316274003981 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 316274003982 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274003983 active site 316274003984 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003986 active site 316274003987 phosphorylation site [posttranslational modification] 316274003988 intermolecular recognition site; other site 316274003989 dimerization interface [polypeptide binding]; other site 316274003990 Response regulator receiver domain; Region: Response_reg; pfam00072 316274003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274003992 active site 316274003993 phosphorylation site [posttranslational modification] 316274003994 intermolecular recognition site; other site 316274003995 dimerization interface [polypeptide binding]; other site 316274003996 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 316274003997 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 316274003998 Replication-relaxation; Region: Replic_Relax; pfam13814 316274003999 Rhomboid family; Region: Rhomboid; cl11446 316274004000 Replication-relaxation; Region: Replic_Relax; pfam13814 316274004001 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316274004002 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274004003 cofactor binding site; other site 316274004004 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 316274004005 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274004006 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 316274004007 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 316274004008 Phage-related protein [Function unknown]; Region: COG5412 316274004009 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 316274004010 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 316274004011 large terminase protein; Provisional; Region: 17; PHA02533 316274004012 Terminase-like family; Region: Terminase_6; pfam03237 316274004013 methionine gamma-lyase; Provisional; Region: PRK07503 316274004014 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 316274004015 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274004016 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 316274004017 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274004018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274004019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004020 non-specific DNA binding site [nucleotide binding]; other site 316274004021 salt bridge; other site 316274004022 sequence-specific DNA binding site [nucleotide binding]; other site 316274004023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274004024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004025 non-specific DNA binding site [nucleotide binding]; other site 316274004026 salt bridge; other site 316274004027 sequence-specific DNA binding site [nucleotide binding]; other site 316274004028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004029 non-specific DNA binding site [nucleotide binding]; other site 316274004030 salt bridge; other site 316274004031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274004032 sequence-specific DNA binding site [nucleotide binding]; other site 316274004033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004034 non-specific DNA binding site [nucleotide binding]; other site 316274004035 salt bridge; other site 316274004036 sequence-specific DNA binding site [nucleotide binding]; other site 316274004037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316274004038 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274004039 Walker A motif; other site 316274004040 ATP binding site [chemical binding]; other site 316274004041 Walker B motif; other site 316274004042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274004043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274004044 Walker A motif; other site 316274004045 ATP binding site [chemical binding]; other site 316274004046 Walker B motif; other site 316274004047 arginine finger; other site 316274004048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316274004049 putative DNA binding site [nucleotide binding]; other site 316274004050 putative Zn2+ binding site [ion binding]; other site 316274004051 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 316274004052 putative metal binding site [ion binding]; other site 316274004053 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 316274004054 YtkA-like; Region: YtkA; pfam13115 316274004055 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 316274004056 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 316274004057 dimer interface [polypeptide binding]; other site 316274004058 anticodon binding site; other site 316274004059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274004060 motif 1; other site 316274004061 dimer interface [polypeptide binding]; other site 316274004062 active site 316274004063 motif 2; other site 316274004064 GAD domain; Region: GAD; pfam02938 316274004065 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274004066 active site 316274004067 motif 3; other site 316274004068 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 316274004069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 316274004070 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 316274004071 DAK2 domain; Region: Dak2; pfam02734 316274004072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004073 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274004074 putative substrate translocation pore; other site 316274004075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004076 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316274004077 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274004078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274004079 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274004080 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274004081 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 316274004082 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 316274004083 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 316274004084 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 316274004085 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274004087 S-adenosylmethionine binding site [chemical binding]; other site 316274004088 short chain dehydrogenase; Provisional; Region: PRK06181 316274004089 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 316274004090 putative NAD(P) binding site [chemical binding]; other site 316274004091 homotetramer interface [polypeptide binding]; other site 316274004092 active site 316274004093 homodimer interface [polypeptide binding]; other site 316274004094 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274004095 GAF domain; Region: GAF_2; pfam13185 316274004096 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274004097 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274004098 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274004099 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274004100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274004101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274004102 anti sigma factor interaction site; other site 316274004103 regulatory phosphorylation site [posttranslational modification]; other site 316274004104 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274004105 anti sigma factor interaction site; other site 316274004106 regulatory phosphorylation site [posttranslational modification]; other site 316274004107 META domain; Region: META; pfam03724 316274004108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274004109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274004110 WHG domain; Region: WHG; pfam13305 316274004111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004112 NAD(P) binding site [chemical binding]; other site 316274004113 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274004114 active site 316274004115 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 316274004116 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274004117 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274004118 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 316274004119 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 316274004120 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 316274004121 putative sugar binding sites [chemical binding]; other site 316274004122 Q-X-W motif; other site 316274004123 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274004124 cyclase homology domain; Region: CHD; cd07302 316274004125 nucleotidyl binding site; other site 316274004126 metal binding site [ion binding]; metal-binding site 316274004127 dimer interface [polypeptide binding]; other site 316274004128 Predicted ATPase [General function prediction only]; Region: COG3899 316274004129 AAA ATPase domain; Region: AAA_16; pfam13191 316274004130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004132 TPR motif; other site 316274004133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004134 binding surface 316274004135 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 316274004136 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 316274004137 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 316274004138 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 316274004139 CVNH domain; Region: CVNH; pfam08881 316274004140 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316274004141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274004142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274004143 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 316274004144 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274004145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274004146 Walker A motif; other site 316274004147 ATP binding site [chemical binding]; other site 316274004148 Walker B motif; other site 316274004149 arginine finger; other site 316274004150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004151 Coenzyme A binding pocket [chemical binding]; other site 316274004152 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 316274004153 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274004154 RHS Repeat; Region: RHS_repeat; pfam05593 316274004155 RHS Repeat; Region: RHS_repeat; cl11982 316274004156 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274004157 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274004158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274004159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274004160 DNA binding site [nucleotide binding] 316274004161 Predicted ATPase [General function prediction only]; Region: COG3903 316274004162 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004164 binding surface 316274004165 TPR motif; other site 316274004166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004167 TPR repeat; Region: TPR_11; pfam13414 316274004168 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 316274004169 SmpB-tmRNA interface; other site 316274004170 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 316274004171 active site 316274004172 dimer interface [polypeptide binding]; other site 316274004173 GAF domain; Region: GAF_3; pfam13492 316274004174 GAF domain; Region: GAF_2; pfam13185 316274004175 GAF domain; Region: GAF_2; pfam13185 316274004176 GAF domain; Region: GAF_3; pfam13492 316274004177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274004178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274004179 dimer interface [polypeptide binding]; other site 316274004180 phosphorylation site [posttranslational modification] 316274004181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004182 ATP binding site [chemical binding]; other site 316274004183 Mg2+ binding site [ion binding]; other site 316274004184 G-X-G motif; other site 316274004185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274004186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274004187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274004188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004189 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 316274004190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274004191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274004192 active site 316274004193 ATP binding site [chemical binding]; other site 316274004194 substrate binding site [chemical binding]; other site 316274004195 activation loop (A-loop); other site 316274004196 Predicted ATPase [General function prediction only]; Region: COG3899 316274004197 AAA ATPase domain; Region: AAA_16; pfam13191 316274004198 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274004199 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274004200 GAF domain; Region: GAF; pfam01590 316274004201 GAF domain; Region: GAF_2; pfam13185 316274004202 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274004203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274004204 metal binding site [ion binding]; metal-binding site 316274004205 active site 316274004206 I-site; other site 316274004207 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274004208 Transposase domain (DUF772); Region: DUF772; pfam05598 316274004209 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274004210 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 316274004211 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274004212 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274004213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274004214 catalytic residue [active] 316274004215 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274004216 Ligand binding site; other site 316274004217 Putative Catalytic site; other site 316274004218 DXD motif; other site 316274004219 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 316274004220 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274004221 cyclase homology domain; Region: CHD; cd07302 316274004222 nucleotidyl binding site; other site 316274004223 metal binding site [ion binding]; metal-binding site 316274004224 dimer interface [polypeptide binding]; other site 316274004225 cyclase homology domain; Region: CHD; cd07302 316274004226 nucleotidyl binding site; other site 316274004227 dimer interface [polypeptide binding]; other site 316274004228 metal binding site [ion binding]; metal-binding site 316274004229 Predicted ATPase [General function prediction only]; Region: COG3899 316274004230 AAA ATPase domain; Region: AAA_16; pfam13191 316274004231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004232 binding surface 316274004233 TPR motif; other site 316274004234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004235 binding surface 316274004236 TPR motif; other site 316274004237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274004240 putative substrate translocation pore; other site 316274004241 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 316274004242 RibD C-terminal domain; Region: RibD_C; cl17279 316274004243 Protein of unknown function (DUF3344); Region: DUF3344; pfam11824 316274004244 hypothetical protein; Provisional; Region: PRK07236 316274004245 hypothetical protein; Provisional; Region: PRK07588 316274004246 maltose O-acetyltransferase; Provisional; Region: PRK10092 316274004247 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 316274004248 active site 316274004249 substrate binding site [chemical binding]; other site 316274004250 trimer interface [polypeptide binding]; other site 316274004251 CoA binding site [chemical binding]; other site 316274004252 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 316274004253 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316274004254 FMN binding site [chemical binding]; other site 316274004255 active site 316274004256 catalytic residues [active] 316274004257 substrate binding site [chemical binding]; other site 316274004258 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 316274004259 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 316274004260 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274004261 TrkA-C domain; Region: TrkA_C; pfam02080 316274004262 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316274004263 FtsX-like permease family; Region: FtsX; pfam02687 316274004264 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316274004265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316274004266 FtsX-like permease family; Region: FtsX; pfam02687 316274004267 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274004268 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316274004269 Walker A/P-loop; other site 316274004270 ATP binding site [chemical binding]; other site 316274004271 Q-loop/lid; other site 316274004272 ABC transporter signature motif; other site 316274004273 Walker B; other site 316274004274 D-loop; other site 316274004275 H-loop/switch region; other site 316274004276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316274004277 HSP70 interaction site [polypeptide binding]; other site 316274004278 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274004279 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274004280 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316274004281 putative acyl-acceptor binding pocket; other site 316274004282 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 316274004283 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274004284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274004285 putative active site [active] 316274004286 heme pocket [chemical binding]; other site 316274004287 PAS fold; Region: PAS_3; pfam08447 316274004288 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274004289 PAS domain S-box; Region: sensory_box; TIGR00229 316274004290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274004291 putative active site [active] 316274004292 heme pocket [chemical binding]; other site 316274004293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274004294 GAF domain; Region: GAF; pfam01590 316274004295 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274004296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274004297 dimer interface [polypeptide binding]; other site 316274004298 phosphorylation site [posttranslational modification] 316274004299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004300 ATP binding site [chemical binding]; other site 316274004301 Mg2+ binding site [ion binding]; other site 316274004302 G-X-G motif; other site 316274004303 Response regulator receiver domain; Region: Response_reg; pfam00072 316274004304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004305 active site 316274004306 phosphorylation site [posttranslational modification] 316274004307 intermolecular recognition site; other site 316274004308 dimerization interface [polypeptide binding]; other site 316274004309 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274004310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004311 active site 316274004312 phosphorylation site [posttranslational modification] 316274004313 intermolecular recognition site; other site 316274004314 dimerization interface [polypeptide binding]; other site 316274004315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274004316 Zn2+ binding site [ion binding]; other site 316274004317 Mg2+ binding site [ion binding]; other site 316274004318 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 316274004319 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 316274004320 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 316274004321 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 316274004322 active site residues [active] 316274004323 dimer interface [polypeptide binding]; other site 316274004324 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 316274004325 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 316274004326 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274004327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274004328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274004329 DNA binding site [nucleotide binding] 316274004330 domain linker motif; other site 316274004331 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 316274004332 putative dimerization interface [polypeptide binding]; other site 316274004333 putative ligand binding site [chemical binding]; other site 316274004334 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 316274004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004336 putative substrate translocation pore; other site 316274004337 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274004338 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 316274004339 catalytic residues [active] 316274004340 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 316274004341 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274004342 DNA binding residues [nucleotide binding] 316274004343 putative dimer interface [polypeptide binding]; other site 316274004344 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274004345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004346 putative substrate translocation pore; other site 316274004347 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274004348 CoenzymeA binding site [chemical binding]; other site 316274004349 subunit interaction site [polypeptide binding]; other site 316274004350 PHB binding site; other site 316274004351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274004352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004353 active site 316274004354 phosphorylation site [posttranslational modification] 316274004355 intermolecular recognition site; other site 316274004356 dimerization interface [polypeptide binding]; other site 316274004357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274004358 DNA binding site [nucleotide binding] 316274004359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274004360 dimerization interface [polypeptide binding]; other site 316274004361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274004362 dimer interface [polypeptide binding]; other site 316274004363 phosphorylation site [posttranslational modification] 316274004364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004365 ATP binding site [chemical binding]; other site 316274004366 Mg2+ binding site [ion binding]; other site 316274004367 G-X-G motif; other site 316274004368 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 316274004369 putative metal binding residues [ion binding]; other site 316274004370 signature motif; other site 316274004371 dimer interface [polypeptide binding]; other site 316274004372 active site 316274004373 polyP binding site; other site 316274004374 substrate binding site [chemical binding]; other site 316274004375 acceptor-phosphate pocket; other site 316274004376 CotH protein; Region: CotH; pfam08757 316274004377 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316274004378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316274004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004380 NAD(P) binding site [chemical binding]; other site 316274004381 active site 316274004382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274004383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274004384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004385 non-specific DNA binding site [nucleotide binding]; other site 316274004386 salt bridge; other site 316274004387 sequence-specific DNA binding site [nucleotide binding]; other site 316274004388 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 316274004389 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 316274004390 Potassium binding sites [ion binding]; other site 316274004391 Cesium cation binding sites [ion binding]; other site 316274004392 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 316274004393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274004394 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 316274004395 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274004396 nudix motif; other site 316274004397 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 316274004398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274004399 catalytic loop [active] 316274004400 iron binding site [ion binding]; other site 316274004401 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274004402 cyclase homology domain; Region: CHD; cd07302 316274004403 nucleotidyl binding site; other site 316274004404 metal binding site [ion binding]; metal-binding site 316274004405 dimer interface [polypeptide binding]; other site 316274004406 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274004407 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274004408 putative NAD(P) binding site [chemical binding]; other site 316274004409 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274004410 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274004411 putative NAD(P) binding site [chemical binding]; other site 316274004412 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274004413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004414 binding surface 316274004415 TPR motif; other site 316274004416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274004417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274004418 DNA binding residues [nucleotide binding] 316274004419 dimerization interface [polypeptide binding]; other site 316274004420 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274004421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004422 Coenzyme A binding pocket [chemical binding]; other site 316274004423 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274004424 active site 316274004425 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 316274004426 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 316274004427 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 316274004428 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 316274004429 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316274004430 substrate binding pocket [chemical binding]; other site 316274004431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274004432 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 316274004433 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316274004434 DNA polymerase III subunit beta; Validated; Region: PRK05643 316274004435 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 316274004436 putative DNA binding surface [nucleotide binding]; other site 316274004437 dimer interface [polypeptide binding]; other site 316274004438 beta-clamp/clamp loader binding surface; other site 316274004439 beta-clamp/translesion DNA polymerase binding surface; other site 316274004440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 316274004441 Beta-lactamase; Region: Beta-lactamase; pfam00144 316274004442 Right handed beta helix region; Region: Beta_helix; pfam13229 316274004443 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 316274004444 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 316274004445 PKC phosphorylation site [posttranslational modification]; other site 316274004446 Predicted transcriptional regulators [Transcription]; Region: COG1733 316274004447 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 316274004448 SCP-2 sterol transfer family; Region: SCP2; pfam02036 316274004449 RibD C-terminal domain; Region: RibD_C; cl17279 316274004450 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 316274004451 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 316274004452 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 316274004453 active site 316274004454 P-loop; other site 316274004455 phosphorylation site [posttranslational modification] 316274004456 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 316274004457 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 316274004458 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 316274004459 active site 316274004460 P-loop; other site 316274004461 phosphorylation site [posttranslational modification] 316274004462 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316274004463 active site 316274004464 phosphorylation site [posttranslational modification] 316274004465 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316274004466 dimerization domain swap beta strand [polypeptide binding]; other site 316274004467 regulatory protein interface [polypeptide binding]; other site 316274004468 active site 316274004469 regulatory phosphorylation site [posttranslational modification]; other site 316274004470 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316274004471 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 316274004472 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316274004473 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316274004474 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316274004475 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 316274004476 NAD(P) binding site [chemical binding]; other site 316274004477 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 316274004478 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 316274004479 putative NAD(P) binding site [chemical binding]; other site 316274004480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274004481 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274004482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 316274004483 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 316274004484 Zn2+ binding site [ion binding]; other site 316274004485 Mg2+ binding site [ion binding]; other site 316274004486 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004489 CHAT domain; Region: CHAT; pfam12770 316274004490 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 316274004491 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 316274004492 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 316274004493 Probable transposase; Region: OrfB_IS605; pfam01385 316274004494 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 316274004495 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 316274004496 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 316274004497 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 316274004498 iron-sulfur cluster [ion binding]; other site 316274004499 [2Fe-2S] cluster binding site [ion binding]; other site 316274004500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 316274004502 DinB family; Region: DinB; cl17821 316274004503 DinB superfamily; Region: DinB_2; pfam12867 316274004504 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 316274004505 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 316274004506 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 316274004507 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 316274004508 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 316274004509 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 316274004510 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 316274004511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274004512 catalytic residue [active] 316274004513 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 316274004514 active site 316274004515 metal binding site [ion binding]; metal-binding site 316274004516 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316274004517 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316274004518 active site 316274004519 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 316274004520 UbiA prenyltransferase family; Region: UbiA; pfam01040 316274004521 Uncharacterized conserved protein [Function unknown]; Region: COG3379 316274004522 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 316274004523 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 316274004524 Phosphotransferase enzyme family; Region: APH; pfam01636 316274004525 putative active site [active] 316274004526 putative substrate binding site [chemical binding]; other site 316274004527 ATP binding site [chemical binding]; other site 316274004528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274004529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274004530 active site 316274004531 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274004532 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274004533 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274004534 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274004535 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 316274004536 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 316274004537 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274004538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004539 active site 316274004540 phosphorylation site [posttranslational modification] 316274004541 intermolecular recognition site; other site 316274004542 dimerization interface [polypeptide binding]; other site 316274004543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274004544 DNA binding residues [nucleotide binding] 316274004545 dimerization interface [polypeptide binding]; other site 316274004546 Maf-like protein; Region: Maf; pfam02545 316274004547 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 316274004548 active site 316274004549 dimer interface [polypeptide binding]; other site 316274004550 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274004551 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 316274004552 active site 316274004553 catalytic residues [active] 316274004554 DNA binding site [nucleotide binding] 316274004555 Int/Topo IB signature motif; other site 316274004556 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 316274004557 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 316274004558 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 316274004559 homodimer interface [polypeptide binding]; other site 316274004560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004561 catalytic residue [active] 316274004562 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 316274004563 phosphate binding motif [ion binding]; other site 316274004564 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274004565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274004566 beta-alpha-beta structure motif; other site 316274004567 S-adenosylmethionine binding site [chemical binding]; other site 316274004568 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 316274004569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274004570 active site 316274004571 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274004572 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274004573 acyl-activating enzyme (AAE) consensus motif; other site 316274004574 AMP binding site [chemical binding]; other site 316274004575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274004576 CoA binding site [chemical binding]; other site 316274004577 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274004578 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274004579 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274004580 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274004581 acyl-activating enzyme (AAE) consensus motif; other site 316274004582 AMP binding site [chemical binding]; other site 316274004583 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274004584 Condensation domain; Region: Condensation; pfam00668 316274004585 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274004586 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274004587 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274004588 acyl-activating enzyme (AAE) consensus motif; other site 316274004589 AMP binding site [chemical binding]; other site 316274004590 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274004591 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274004592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274004593 putative substrate translocation pore; other site 316274004594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274004595 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 316274004596 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316274004597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274004598 dimer interface [polypeptide binding]; other site 316274004599 conserved gate region; other site 316274004600 putative PBP binding loops; other site 316274004601 ABC-ATPase subunit interface; other site 316274004602 NMT1/THI5 like; Region: NMT1; pfam09084 316274004603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 316274004604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 316274004605 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 316274004606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274004607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274004608 SnoaL-like domain; Region: SnoaL_2; pfam12680 316274004609 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 316274004610 ATP cone domain; Region: ATP-cone; pfam03477 316274004611 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 316274004612 Restriction endonuclease; Region: Mrr_cat; pfam04471 316274004613 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 316274004614 homopentamer interface [polypeptide binding]; other site 316274004615 active site 316274004616 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 316274004617 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274004618 dimer interface [polypeptide binding]; other site 316274004619 active site 316274004620 ribonuclease III; Reviewed; Region: rnc; PRK00102 316274004621 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 316274004622 dimerization interface [polypeptide binding]; other site 316274004623 active site 316274004624 metal binding site [ion binding]; metal-binding site 316274004625 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 316274004626 dsRNA binding site [nucleotide binding]; other site 316274004627 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274004630 DNA binding residues [nucleotide binding] 316274004631 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 316274004632 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 316274004633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274004634 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274004635 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274004636 Probable Catalytic site; other site 316274004637 metal-binding site 316274004638 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 316274004639 Putative esterase; Region: Esterase; pfam00756 316274004640 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 316274004641 putative active site [active] 316274004642 putative metal binding site [ion binding]; other site 316274004643 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 316274004644 Predicted ATPase [General function prediction only]; Region: COG3903 316274004645 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004648 binding surface 316274004649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004650 TPR motif; other site 316274004651 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 316274004652 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274004653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274004654 dimerization interface [polypeptide binding]; other site 316274004655 putative DNA binding site [nucleotide binding]; other site 316274004656 putative Zn2+ binding site [ion binding]; other site 316274004657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004659 active site 316274004660 phosphorylation site [posttranslational modification] 316274004661 intermolecular recognition site; other site 316274004662 dimerization interface [polypeptide binding]; other site 316274004663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274004664 DNA binding residues [nucleotide binding] 316274004665 dimerization interface [polypeptide binding]; other site 316274004666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274004667 Histidine kinase; Region: HisKA_3; pfam07730 316274004668 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316274004669 ATP binding site [chemical binding]; other site 316274004670 Mg2+ binding site [ion binding]; other site 316274004671 G-X-G motif; other site 316274004672 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316274004673 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316274004674 HlyD family secretion protein; Region: HlyD_3; pfam13437 316274004675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274004676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316274004677 Walker A/P-loop; other site 316274004678 ATP binding site [chemical binding]; other site 316274004679 Q-loop/lid; other site 316274004680 ABC transporter signature motif; other site 316274004681 Walker B; other site 316274004682 D-loop; other site 316274004683 H-loop/switch region; other site 316274004684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316274004685 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316274004686 FtsX-like permease family; Region: FtsX; pfam02687 316274004687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274004688 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 316274004689 peptide binding site [polypeptide binding]; other site 316274004690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274004692 dimer interface [polypeptide binding]; other site 316274004693 conserved gate region; other site 316274004694 putative PBP binding loops; other site 316274004695 ABC-ATPase subunit interface; other site 316274004696 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274004697 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274004698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274004699 dimer interface [polypeptide binding]; other site 316274004700 conserved gate region; other site 316274004701 putative PBP binding loops; other site 316274004702 ABC-ATPase subunit interface; other site 316274004703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274004704 non-specific DNA binding site [nucleotide binding]; other site 316274004705 salt bridge; other site 316274004706 sequence-specific DNA binding site [nucleotide binding]; other site 316274004707 Predicted ATPase [General function prediction only]; Region: COG3903 316274004708 AAA domain; Region: AAA_14; pfam13173 316274004709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274004710 TPR motif; other site 316274004711 binding surface 316274004712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004713 Response regulator receiver domain; Region: Response_reg; pfam00072 316274004714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004715 active site 316274004716 phosphorylation site [posttranslational modification] 316274004717 intermolecular recognition site; other site 316274004718 dimerization interface [polypeptide binding]; other site 316274004719 GAF domain; Region: GAF_2; pfam13185 316274004720 GAF domain; Region: GAF_3; pfam13492 316274004721 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274004722 cyclase homology domain; Region: CHD; cd07302 316274004723 nucleotidyl binding site; other site 316274004724 metal binding site [ion binding]; metal-binding site 316274004725 dimer interface [polypeptide binding]; other site 316274004726 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274004727 diphosphomevalonate decarboxylase; Region: PLN02407 316274004728 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 316274004729 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274004730 active site 316274004731 catalytic site [active] 316274004732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004733 binding surface 316274004734 TPR repeat; Region: TPR_11; pfam13414 316274004735 TPR motif; other site 316274004736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274004737 S-adenosylmethionine binding site [chemical binding]; other site 316274004738 V4R domain; Region: V4R; cl15268 316274004739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 316274004740 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 316274004741 Predicted acetyltransferase [General function prediction only]; Region: COG3393 316274004742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004743 Coenzyme A binding pocket [chemical binding]; other site 316274004744 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316274004745 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 316274004746 putative dimer interface [polypeptide binding]; other site 316274004747 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274004748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274004749 Walker A motif; other site 316274004750 ATP binding site [chemical binding]; other site 316274004751 Walker B motif; other site 316274004752 arginine finger; other site 316274004753 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274004754 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274004755 anti sigma factor interaction site; other site 316274004756 regulatory phosphorylation site [posttranslational modification]; other site 316274004757 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274004758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274004759 ATP binding site [chemical binding]; other site 316274004760 Mg2+ binding site [ion binding]; other site 316274004761 G-X-G motif; other site 316274004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274004763 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274004764 Mg2+ binding site [ion binding]; other site 316274004765 YaeQ protein; Region: YaeQ; pfam07152 316274004766 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 316274004767 endonuclease IV; Provisional; Region: PRK01060 316274004768 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 316274004769 AP (apurinic/apyrimidinic) site pocket; other site 316274004770 DNA interaction; other site 316274004771 Metal-binding active site; metal-binding site 316274004772 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 316274004773 MOSC domain; Region: MOSC; pfam03473 316274004774 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274004775 PhoU domain; Region: PhoU; pfam01895 316274004776 PhoU domain; Region: PhoU; pfam01895 316274004777 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274004778 PhoU domain; Region: PhoU; pfam01895 316274004779 PhoU domain; Region: PhoU; pfam01895 316274004780 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274004781 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274004782 SLBB domain; Region: SLBB; pfam10531 316274004783 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316274004784 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 316274004785 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 316274004786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274004787 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 316274004788 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 316274004789 Predicted permeases [General function prediction only]; Region: COG0730 316274004790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274004791 active site residue [active] 316274004792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274004793 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316274004794 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274004795 active site residue [active] 316274004796 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274004797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274004799 DNA binding residues [nucleotide binding] 316274004800 uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914 316274004801 putative active site [active] 316274004802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274004803 Cna protein B-type domain; Region: Cna_B; pfam05738 316274004804 Cna protein B-type domain; Region: Cna_B; pfam05738 316274004805 Cna protein B-type domain; Region: Cna_B; pfam05738 316274004806 Cna protein B-type domain; Region: Cna_B; pfam05738 316274004807 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 316274004808 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 316274004809 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 316274004810 active site 316274004811 catalytic site [active] 316274004812 metal binding site [ion binding]; metal-binding site 316274004813 dimer interface [polypeptide binding]; other site 316274004814 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316274004815 Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733 316274004816 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274004817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004818 Coenzyme A binding pocket [chemical binding]; other site 316274004819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274004820 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 316274004821 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 316274004822 classical (c) SDRs; Region: SDR_c; cd05233 316274004823 NAD(P) binding site [chemical binding]; other site 316274004824 active site 316274004825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274004826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274004827 Coenzyme A binding pocket [chemical binding]; other site 316274004828 hypothetical protein; Provisional; Region: PRK08201 316274004829 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 316274004830 metal binding site [ion binding]; metal-binding site 316274004831 putative dimer interface [polypeptide binding]; other site 316274004832 Predicted permeases [General function prediction only]; Region: RarD; COG2962 316274004833 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274004834 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316274004835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274004836 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274004837 Walker A/P-loop; other site 316274004838 ATP binding site [chemical binding]; other site 316274004839 Q-loop/lid; other site 316274004840 ABC transporter signature motif; other site 316274004841 Walker B; other site 316274004842 D-loop; other site 316274004843 H-loop/switch region; other site 316274004844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274004845 DNA-binding site [nucleotide binding]; DNA binding site 316274004846 Cellulose binding domain; Region: CBM_2; pfam00553 316274004847 DoxX-like family; Region: DoxX_2; pfam13564 316274004848 Predicted flavoprotein [General function prediction only]; Region: COG0431 316274004849 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 316274004850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274004851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274004852 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 316274004853 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274004854 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 316274004855 putative acyl-acceptor binding pocket; other site 316274004856 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 316274004857 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274004858 putative NAD(P) binding site [chemical binding]; other site 316274004859 active site 316274004860 putative substrate binding site [chemical binding]; other site 316274004861 Fic/DOC family; Region: Fic; pfam02661 316274004862 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 316274004863 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 316274004864 dimer interface [polypeptide binding]; other site 316274004865 putative anticodon binding site; other site 316274004866 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 316274004867 motif 1; other site 316274004868 active site 316274004869 motif 2; other site 316274004870 motif 3; other site 316274004871 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 316274004872 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 316274004873 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316274004874 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 316274004875 DEAD/DEAH box helicase; Region: DEAD; pfam00270 316274004876 DEAD/DEAH box helicase; Region: DEAD; pfam00270 316274004877 putative Mg++ binding site [ion binding]; other site 316274004878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274004879 ATP-binding site [chemical binding]; other site 316274004880 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 316274004881 Nuclease-related domain; Region: NERD; pfam08378 316274004882 Part of AAA domain; Region: AAA_19; pfam13245 316274004883 Family description; Region: UvrD_C_2; pfam13538 316274004884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 316274004885 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 316274004886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274004887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274004888 active site 316274004889 catalytic tetrad [active] 316274004890 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 316274004891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274004892 active site 316274004893 catalytic tetrad [active] 316274004894 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316274004895 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274004896 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274004897 acyl-activating enzyme (AAE) consensus motif; other site 316274004898 AMP binding site [chemical binding]; other site 316274004899 active site 316274004900 CoA binding site [chemical binding]; other site 316274004901 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 316274004902 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 316274004903 substrate binding site [chemical binding]; other site 316274004904 active site 316274004905 catalytic residues [active] 316274004906 heterodimer interface [polypeptide binding]; other site 316274004907 Predicted permeases [General function prediction only]; Region: COG0701 316274004908 TIGR03943 family protein; Region: TIGR03943 316274004909 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 316274004910 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 316274004911 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 316274004912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274004913 NmrA-like family; Region: NmrA; pfam05368 316274004914 NAD(P) binding site [chemical binding]; other site 316274004915 active site 316274004916 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274004917 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274004918 DNA binding residues [nucleotide binding] 316274004919 drug binding residues [chemical binding]; other site 316274004920 dimer interface [polypeptide binding]; other site 316274004921 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 316274004922 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 316274004923 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274004924 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 316274004925 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 316274004926 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 316274004927 active site 316274004928 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004930 binding surface 316274004931 TPR motif; other site 316274004932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274004934 binding surface 316274004935 TPR motif; other site 316274004936 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274004937 CHAT domain; Region: CHAT; pfam12770 316274004938 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 316274004939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274004940 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274004941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274004942 active site 316274004943 phosphorylation site [posttranslational modification] 316274004944 intermolecular recognition site; other site 316274004945 dimerization interface [polypeptide binding]; other site 316274004946 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 316274004947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274004948 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 316274004949 hydroxyglutarate oxidase; Provisional; Region: PRK11728 316274004950 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 316274004951 dimer interface [polypeptide binding]; other site 316274004952 substrate binding site [chemical binding]; other site 316274004953 metal binding sites [ion binding]; metal-binding site 316274004954 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 316274004955 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 316274004956 FMN binding site [chemical binding]; other site 316274004957 substrate binding site [chemical binding]; other site 316274004958 putative catalytic residue [active] 316274004959 MutS domain III; Region: MutS_III; cl17822 316274004960 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 316274004961 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274004962 DNA binding residues [nucleotide binding] 316274004963 putative dimer interface [polypeptide binding]; other site 316274004964 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 316274004965 DNA binding residues [nucleotide binding] 316274004966 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316274004967 putative dimer interface [polypeptide binding]; other site 316274004968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274004969 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 316274004970 Walker A/P-loop; other site 316274004971 ATP binding site [chemical binding]; other site 316274004972 Q-loop/lid; other site 316274004973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274004974 ABC transporter signature motif; other site 316274004975 Walker B; other site 316274004976 D-loop; other site 316274004977 H-loop/switch region; other site 316274004978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274004979 Walker A/P-loop; other site 316274004980 ATP binding site [chemical binding]; other site 316274004981 Q-loop/lid; other site 316274004982 ABC transporter signature motif; other site 316274004983 Walker B; other site 316274004984 D-loop; other site 316274004985 H-loop/switch region; other site 316274004986 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 316274004987 amidase catalytic site [active] 316274004988 Zn binding residues [ion binding]; other site 316274004989 substrate binding site [chemical binding]; other site 316274004990 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 316274004991 UbiA prenyltransferase family; Region: UbiA; pfam01040 316274004992 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 316274004993 homodimer interface [polypeptide binding]; other site 316274004994 substrate-cofactor binding pocket; other site 316274004995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274004996 catalytic residue [active] 316274004997 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274004998 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 316274004999 Walker A/P-loop; other site 316274005000 ATP binding site [chemical binding]; other site 316274005001 Q-loop/lid; other site 316274005002 ABC transporter signature motif; other site 316274005003 Walker B; other site 316274005004 D-loop; other site 316274005005 H-loop/switch region; other site 316274005006 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274005008 dimer interface [polypeptide binding]; other site 316274005009 conserved gate region; other site 316274005010 putative PBP binding loops; other site 316274005011 ABC-ATPase subunit interface; other site 316274005012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274005013 dimer interface [polypeptide binding]; other site 316274005014 conserved gate region; other site 316274005015 putative PBP binding loops; other site 316274005016 ABC-ATPase subunit interface; other site 316274005017 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 316274005018 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316274005019 Transposase domain (DUF772); Region: DUF772; pfam05598 316274005020 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274005021 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 316274005022 FAD binding domain; Region: FAD_binding_2; pfam00890 316274005023 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274005024 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 316274005025 putative NAD(P) binding site [chemical binding]; other site 316274005026 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 316274005027 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274005028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316274005029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005030 binding surface 316274005031 TPR motif; other site 316274005032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274005033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274005034 DNA binding residues [nucleotide binding] 316274005035 dimerization interface [polypeptide binding]; other site 316274005036 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 316274005037 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 316274005038 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 316274005039 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 316274005040 L-aspartate oxidase; Provisional; Region: PRK06175 316274005041 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316274005042 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 316274005043 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 316274005044 putative Iron-sulfur protein interface [polypeptide binding]; other site 316274005045 proximal heme binding site [chemical binding]; other site 316274005046 distal heme binding site [chemical binding]; other site 316274005047 putative dimer interface [polypeptide binding]; other site 316274005048 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316274005049 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005050 ABC-ATPase subunit interface; other site 316274005051 dimer interface [polypeptide binding]; other site 316274005052 putative PBP binding regions; other site 316274005053 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274005054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005055 ABC-ATPase subunit interface; other site 316274005056 dimer interface [polypeptide binding]; other site 316274005057 putative PBP binding regions; other site 316274005058 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274005059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274005060 Walker A/P-loop; other site 316274005061 ATP binding site [chemical binding]; other site 316274005062 Q-loop/lid; other site 316274005063 ABC transporter signature motif; other site 316274005064 Walker B; other site 316274005065 D-loop; other site 316274005066 H-loop/switch region; other site 316274005067 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 316274005068 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 316274005069 siderophore binding site; other site 316274005070 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 316274005071 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 316274005072 siderophore binding site; other site 316274005073 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 316274005074 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 316274005075 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 316274005076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274005077 MarR family; Region: MarR; pfam01047 316274005078 CTP synthetase; Validated; Region: pyrG; PRK05380 316274005079 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 316274005080 Catalytic site [active] 316274005081 active site 316274005082 UTP binding site [chemical binding]; other site 316274005083 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 316274005084 active site 316274005085 putative oxyanion hole; other site 316274005086 catalytic triad [active] 316274005087 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 316274005088 active site 316274005089 SAM binding site [chemical binding]; other site 316274005090 homodimer interface [polypeptide binding]; other site 316274005091 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 316274005092 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 316274005093 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 316274005094 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274005095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274005096 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 316274005097 ligand-binding site [chemical binding]; other site 316274005098 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 316274005099 ATP-sulfurylase; Region: ATPS; cd00517 316274005100 active site 316274005101 HXXH motif; other site 316274005102 flexible loop; other site 316274005103 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 316274005104 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316274005105 Active Sites [active] 316274005106 methionine sulfoxide reductase A; Provisional; Region: PRK14054 316274005107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005109 murein hydrolase B; Provisional; Region: PRK10760; cl17906 316274005110 Domain of unknown function DUF11; Region: DUF11; cl17728 316274005111 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316274005112 active site 316274005113 NTP binding site [chemical binding]; other site 316274005114 metal binding triad [ion binding]; metal-binding site 316274005115 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274005116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274005118 DNA binding residues [nucleotide binding] 316274005119 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316274005120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 316274005121 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 316274005122 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 316274005123 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274005124 translocation protein TolB; Provisional; Region: tolB; PRK01742 316274005125 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274005126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274005127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274005128 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 316274005129 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 316274005130 xylose isomerase; Provisional; Region: PRK12677 316274005131 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 316274005132 N- and C-terminal domain interface [polypeptide binding]; other site 316274005133 D-xylulose kinase; Region: XylB; TIGR01312 316274005134 active site 316274005135 MgATP binding site [chemical binding]; other site 316274005136 catalytic site [active] 316274005137 metal binding site [ion binding]; metal-binding site 316274005138 xylulose binding site [chemical binding]; other site 316274005139 homodimer interface [polypeptide binding]; other site 316274005140 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 316274005141 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 316274005142 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 316274005143 SWIM zinc finger; Region: SWIM; pfam04434 316274005144 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 316274005145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274005146 ATP binding site [chemical binding]; other site 316274005147 putative Mg++ binding site [ion binding]; other site 316274005148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274005149 nucleotide binding region [chemical binding]; other site 316274005150 ATP-binding site [chemical binding]; other site 316274005151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274005152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274005153 DNA binding site [nucleotide binding] 316274005154 domain linker motif; other site 316274005155 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274005156 putative dimerization interface [polypeptide binding]; other site 316274005157 putative ligand binding site [chemical binding]; other site 316274005158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274005159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274005160 active site 316274005161 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 316274005162 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 316274005163 NAD binding site [chemical binding]; other site 316274005164 homodimer interface [polypeptide binding]; other site 316274005165 active site 316274005166 substrate binding site [chemical binding]; other site 316274005167 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274005168 CoenzymeA binding site [chemical binding]; other site 316274005169 subunit interaction site [polypeptide binding]; other site 316274005170 PHB binding site; other site 316274005171 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 316274005172 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 316274005173 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 316274005174 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 316274005175 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 316274005176 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 316274005177 Baseplate J-like protein; Region: Baseplate_J; cl01294 316274005178 H-type lectin domain; Region: H_lectin; pfam09458 316274005179 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274005181 S-adenosylmethionine binding site [chemical binding]; other site 316274005182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 316274005183 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274005184 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274005185 Probable Catalytic site; other site 316274005186 metal-binding site 316274005187 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 316274005188 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316274005189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274005190 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274005191 active site 316274005192 catalytic tetrad [active] 316274005193 hypothetical protein; Provisional; Region: PRK02237 316274005194 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 316274005195 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 316274005196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274005197 NAD(P) binding site [chemical binding]; other site 316274005198 active site 316274005199 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 316274005200 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316274005201 isochorismate synthase DhbC; Validated; Region: PRK06923 316274005202 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 316274005203 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 316274005204 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 316274005205 acyl-activating enzyme (AAE) consensus motif; other site 316274005206 active site 316274005207 AMP binding site [chemical binding]; other site 316274005208 substrate binding site [chemical binding]; other site 316274005209 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316274005210 Isochorismatase family; Region: Isochorismatase; pfam00857 316274005211 catalytic triad [active] 316274005212 conserved cis-peptide bond; other site 316274005213 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 316274005214 Condensation domain; Region: Condensation; pfam00668 316274005215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005216 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005217 acyl-activating enzyme (AAE) consensus motif; other site 316274005218 AMP binding site [chemical binding]; other site 316274005219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005220 thioester reductase domain; Region: Thioester-redct; TIGR01746 316274005221 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 316274005222 putative NAD(P) binding site [chemical binding]; other site 316274005223 active site 316274005224 putative substrate binding site [chemical binding]; other site 316274005225 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 316274005226 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 316274005227 siderophore binding site; other site 316274005228 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274005229 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 316274005230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005231 ABC-ATPase subunit interface; other site 316274005232 dimer interface [polypeptide binding]; other site 316274005233 putative PBP binding regions; other site 316274005234 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274005235 ABC-ATPase subunit interface; other site 316274005236 dimer interface [polypeptide binding]; other site 316274005237 putative PBP binding regions; other site 316274005238 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274005239 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274005240 Walker A/P-loop; other site 316274005241 ATP binding site [chemical binding]; other site 316274005242 Q-loop/lid; other site 316274005243 ABC transporter signature motif; other site 316274005244 Walker B; other site 316274005245 D-loop; other site 316274005246 H-loop/switch region; other site 316274005247 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 316274005248 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 316274005249 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274005250 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274005251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274005252 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274005253 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274005254 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274005255 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274005256 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274005257 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274005258 Family description; Region: VCBS; pfam13517 316274005259 Family description; Region: VCBS; pfam13517 316274005260 Family description; Region: VCBS; pfam13517 316274005261 Clostripain family; Region: Peptidase_C11; pfam03415 316274005262 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316274005263 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 316274005264 active site 316274005265 Zn binding site [ion binding]; other site 316274005266 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 316274005267 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 316274005268 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274005269 sugar binding site [chemical binding]; other site 316274005270 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274005271 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 316274005272 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274005273 G1 box; other site 316274005274 GTP/Mg2+ binding site [chemical binding]; other site 316274005275 G2 box; other site 316274005276 Switch I region; other site 316274005277 G3 box; other site 316274005278 Switch II region; other site 316274005279 G4 box; other site 316274005280 G5 box; other site 316274005281 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274005282 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274005283 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274005284 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274005285 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274005286 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274005287 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 316274005288 putative active site [active] 316274005289 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274005290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274005291 Walker A/P-loop; other site 316274005292 ATP binding site [chemical binding]; other site 316274005293 Q-loop/lid; other site 316274005294 ABC transporter signature motif; other site 316274005295 Walker B; other site 316274005296 D-loop; other site 316274005297 H-loop/switch region; other site 316274005298 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 316274005299 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274005300 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274005301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274005302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274005303 Walker A/P-loop; other site 316274005304 ATP binding site [chemical binding]; other site 316274005305 Q-loop/lid; other site 316274005306 ABC transporter signature motif; other site 316274005307 Walker B; other site 316274005308 D-loop; other site 316274005309 H-loop/switch region; other site 316274005310 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274005311 Leucine-rich repeats; other site 316274005312 Substrate binding site [chemical binding]; other site 316274005313 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274005314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274005315 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005316 active site 316274005317 phosphorylation site [posttranslational modification] 316274005318 intermolecular recognition site; other site 316274005319 dimerization interface [polypeptide binding]; other site 316274005320 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 316274005321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274005322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274005323 dimer interface [polypeptide binding]; other site 316274005324 phosphorylation site [posttranslational modification] 316274005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005326 ATP binding site [chemical binding]; other site 316274005327 Mg2+ binding site [ion binding]; other site 316274005328 G-X-G motif; other site 316274005329 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274005330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274005331 active site 316274005332 phosphorylation site [posttranslational modification] 316274005333 intermolecular recognition site; other site 316274005334 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316274005335 Ligand binding site [chemical binding]; other site 316274005336 Electron transfer flavoprotein domain; Region: ETF; pfam01012 316274005337 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316274005338 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 316274005339 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316274005340 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 316274005341 active site 316274005342 homodimer interface [polypeptide binding]; other site 316274005343 homotetramer interface [polypeptide binding]; other site 316274005344 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 316274005345 glycogen synthase; Provisional; Region: glgA; PRK00654 316274005346 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316274005347 ADP-binding pocket [chemical binding]; other site 316274005348 homodimer interface [polypeptide binding]; other site 316274005349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274005350 FeS/SAM binding site; other site 316274005351 coproporphyrinogen III oxidase; Validated; Region: PRK08208 316274005352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274005353 FeS/SAM binding site; other site 316274005354 HemN C-terminal domain; Region: HemN_C; pfam06969 316274005355 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 316274005356 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 316274005357 homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP); Region: Mog1; cl00169 316274005358 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274005359 Substrate binding site [chemical binding]; other site 316274005360 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274005361 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316274005362 putative transporter; Validated; Region: PRK03818 316274005363 TrkA-C domain; Region: TrkA_C; pfam02080 316274005364 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 316274005365 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005366 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 316274005367 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005368 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005369 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 316274005370 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 316274005371 short chain dehydrogenase; Provisional; Region: PRK07806 316274005372 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 316274005373 NAD(P) binding site [chemical binding]; other site 316274005374 active site 316274005375 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274005376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274005377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274005378 DNA binding residues [nucleotide binding] 316274005379 dimerization interface [polypeptide binding]; other site 316274005380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005381 sequence-specific DNA binding site [nucleotide binding]; other site 316274005382 salt bridge; other site 316274005383 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274005384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005385 non-specific DNA binding site [nucleotide binding]; other site 316274005386 salt bridge; other site 316274005387 sequence-specific DNA binding site [nucleotide binding]; other site 316274005388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274005389 Predicted ATPase [General function prediction only]; Region: COG3903 316274005390 Walker A motif; other site 316274005391 ATP binding site [chemical binding]; other site 316274005392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005393 binding surface 316274005394 TPR motif; other site 316274005395 acyl-CoA synthetase; Validated; Region: PRK05850 316274005396 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 316274005397 acyl-activating enzyme (AAE) consensus motif; other site 316274005398 active site 316274005399 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274005400 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274005401 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274005402 active site 316274005403 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274005404 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274005405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005406 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 316274005407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274005408 inhibitor-cofactor binding pocket; inhibition site 316274005409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274005410 catalytic residue [active] 316274005411 Condensation domain; Region: Condensation; pfam00668 316274005412 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005413 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005414 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005415 acyl-activating enzyme (AAE) consensus motif; other site 316274005416 AMP binding site [chemical binding]; other site 316274005417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274005418 S-adenosylmethionine binding site [chemical binding]; other site 316274005419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274005420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005421 Condensation domain; Region: Condensation; pfam00668 316274005422 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005423 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005425 acyl-activating enzyme (AAE) consensus motif; other site 316274005426 AMP binding site [chemical binding]; other site 316274005427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005428 Condensation domain; Region: Condensation; pfam00668 316274005429 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005430 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005431 Condensation domain; Region: Condensation; pfam00668 316274005432 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005433 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005434 acyl-activating enzyme (AAE) consensus motif; other site 316274005435 AMP binding site [chemical binding]; other site 316274005436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005437 Condensation domain; Region: Condensation; pfam00668 316274005438 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005439 Condensation domain; Region: Condensation; pfam00668 316274005440 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005441 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005442 acyl-activating enzyme (AAE) consensus motif; other site 316274005443 AMP binding site [chemical binding]; other site 316274005444 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274005445 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274005446 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274005447 active site 316274005448 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274005449 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274005450 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274005451 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274005452 putative NADP binding site [chemical binding]; other site 316274005453 active site 316274005454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005455 Condensation domain; Region: Condensation; pfam00668 316274005456 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005457 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005458 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005459 acyl-activating enzyme (AAE) consensus motif; other site 316274005460 AMP binding site [chemical binding]; other site 316274005461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005462 Condensation domain; Region: Condensation; pfam00668 316274005463 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005464 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005465 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274005466 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 316274005467 acyl-activating enzyme (AAE) consensus motif; other site 316274005468 AMP binding site [chemical binding]; other site 316274005469 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005470 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274005471 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274005472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274005473 putative substrate translocation pore; other site 316274005474 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 316274005475 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316274005476 dimer interface [polypeptide binding]; other site 316274005477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274005478 catalytic residue [active] 316274005479 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 316274005480 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 316274005481 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 316274005482 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005483 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005484 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005485 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005486 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005487 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005488 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274005490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005491 non-specific DNA binding site [nucleotide binding]; other site 316274005492 salt bridge; other site 316274005493 sequence-specific DNA binding site [nucleotide binding]; other site 316274005494 Predicted ATPase [General function prediction only]; Region: COG3903 316274005495 AAA domain; Region: AAA_17; pfam13207 316274005496 TPR repeat; Region: TPR_11; pfam13414 316274005497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005498 binding surface 316274005499 TPR motif; other site 316274005500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005501 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274005503 Coenzyme A binding pocket [chemical binding]; other site 316274005504 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 316274005505 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 316274005506 active site 316274005507 zinc binding site [ion binding]; other site 316274005508 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274005509 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 316274005510 putative active site [active] 316274005511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274005512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274005513 Walker A/P-loop; other site 316274005514 ATP binding site [chemical binding]; other site 316274005515 Q-loop/lid; other site 316274005516 ABC transporter signature motif; other site 316274005517 Walker B; other site 316274005518 D-loop; other site 316274005519 H-loop/switch region; other site 316274005520 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 316274005521 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 316274005522 active site 316274005523 substrate binding site [chemical binding]; other site 316274005524 FMN binding site [chemical binding]; other site 316274005525 putative catalytic residues [active] 316274005526 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274005527 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274005528 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274005529 active site 316274005530 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274005531 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 316274005532 Methyltransferase domain; Region: Methyltransf_12; pfam08242 316274005533 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274005534 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274005535 KR domain; Region: KR; pfam08659 316274005536 putative NADP binding site [chemical binding]; other site 316274005537 active site 316274005538 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274005539 Condensation domain; Region: Condensation; pfam00668 316274005540 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005541 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005542 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005543 acyl-activating enzyme (AAE) consensus motif; other site 316274005544 AMP binding site [chemical binding]; other site 316274005545 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005546 Condensation domain; Region: Condensation; pfam00668 316274005547 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005548 Condensation domain; Region: Condensation; pfam00668 316274005549 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005551 acyl-activating enzyme (AAE) consensus motif; other site 316274005552 AMP binding site [chemical binding]; other site 316274005553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005554 Condensation domain; Region: Condensation; pfam00668 316274005555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005556 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005557 Condensation domain; Region: Condensation; pfam00668 316274005558 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005559 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 316274005560 Condensation domain; Region: Condensation; pfam00668 316274005561 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005562 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005563 acyl-activating enzyme (AAE) consensus motif; other site 316274005564 AMP binding site [chemical binding]; other site 316274005565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005566 Condensation domain; Region: Condensation; pfam00668 316274005567 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005568 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274005569 Condensation domain; Region: Condensation; pfam00668 316274005570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005571 Condensation domain; Region: Condensation; pfam00668 316274005572 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005573 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274005574 acyl-activating enzyme (AAE) consensus motif; other site 316274005575 AMP binding site [chemical binding]; other site 316274005576 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 316274005577 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005578 Condensation domain; Region: Condensation; pfam00668 316274005579 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005580 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005582 acyl-activating enzyme (AAE) consensus motif; other site 316274005583 AMP binding site [chemical binding]; other site 316274005584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005585 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 316274005586 Condensation domain; Region: Condensation; pfam00668 316274005587 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005588 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005589 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 316274005590 acyl-activating enzyme (AAE) consensus motif; other site 316274005591 AMP binding site [chemical binding]; other site 316274005592 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005593 Condensation domain; Region: Condensation; pfam00668 316274005594 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005595 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274005597 Condensation domain; Region: Condensation; pfam00668 316274005598 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005599 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005600 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 316274005601 acyl-activating enzyme (AAE) consensus motif; other site 316274005602 AMP binding site [chemical binding]; other site 316274005603 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005604 Condensation domain; Region: Condensation; pfam00668 316274005605 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005606 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005607 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005608 acyl-activating enzyme (AAE) consensus motif; other site 316274005609 AMP binding site [chemical binding]; other site 316274005610 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005611 Condensation domain; Region: Condensation; pfam00668 316274005612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005613 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005614 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 316274005615 acyl-activating enzyme (AAE) consensus motif; other site 316274005616 AMP binding site [chemical binding]; other site 316274005617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005618 Condensation domain; Region: Condensation; pfam00668 316274005619 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274005620 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005621 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274005622 acyl-activating enzyme (AAE) consensus motif; other site 316274005623 AMP binding site [chemical binding]; other site 316274005624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005625 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274005626 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274005627 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 316274005628 acyl-activating enzyme (AAE) consensus motif; other site 316274005629 AMP binding site [chemical binding]; other site 316274005630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274005631 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274005632 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274005633 active sites [active] 316274005634 tetramer interface [polypeptide binding]; other site 316274005635 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 316274005636 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 316274005637 acyl-activating enzyme (AAE) consensus motif; other site 316274005638 putative AMP binding site [chemical binding]; other site 316274005639 putative active site [active] 316274005640 putative CoA binding site [chemical binding]; other site 316274005641 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 316274005642 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274005643 homodimer interface [polypeptide binding]; other site 316274005644 glycosyltransferase, MGT family; Region: MGT; TIGR01426 316274005645 active site 316274005646 TDP-binding site; other site 316274005647 acceptor substrate-binding pocket; other site 316274005648 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 316274005649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274005650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274005651 homodimer interface [polypeptide binding]; other site 316274005652 catalytic residue [active] 316274005653 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 316274005654 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 316274005655 dimer interface [polypeptide binding]; other site 316274005656 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 316274005657 active site 316274005658 Fe binding site [ion binding]; other site 316274005659 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274005660 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274005661 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274005662 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 316274005663 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274005664 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316274005665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274005666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274005667 Walker A/P-loop; other site 316274005668 ATP binding site [chemical binding]; other site 316274005669 Q-loop/lid; other site 316274005670 ABC transporter signature motif; other site 316274005671 Walker B; other site 316274005672 D-loop; other site 316274005673 H-loop/switch region; other site 316274005674 SET domain; Region: SET; pfam00856 316274005675 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005676 transcriptional regulator MalT; Provisional; Region: PRK04841 316274005677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274005678 dimerization interface [polypeptide binding]; other site 316274005679 DNA binding residues [nucleotide binding] 316274005680 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 316274005681 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274005682 peptide binding site [polypeptide binding]; other site 316274005683 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274005684 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 316274005685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274005686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274005687 dimer interface [polypeptide binding]; other site 316274005688 conserved gate region; other site 316274005689 putative PBP binding loops; other site 316274005690 ABC-ATPase subunit interface; other site 316274005691 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274005692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274005693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274005694 dimer interface [polypeptide binding]; other site 316274005695 conserved gate region; other site 316274005696 putative PBP binding loops; other site 316274005697 ABC-ATPase subunit interface; other site 316274005698 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274005699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274005700 Walker A/P-loop; other site 316274005701 ATP binding site [chemical binding]; other site 316274005702 Q-loop/lid; other site 316274005703 ABC transporter signature motif; other site 316274005704 Walker B; other site 316274005705 D-loop; other site 316274005706 H-loop/switch region; other site 316274005707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274005708 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 316274005709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274005710 Walker A/P-loop; other site 316274005711 ATP binding site [chemical binding]; other site 316274005712 Q-loop/lid; other site 316274005713 ABC transporter signature motif; other site 316274005714 Walker B; other site 316274005715 D-loop; other site 316274005716 H-loop/switch region; other site 316274005717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316274005718 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 316274005719 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274005720 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 316274005721 ligand binding site [chemical binding]; other site 316274005722 dimerization interface [polypeptide binding]; other site 316274005723 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005724 peptide chain release factor 2; Validated; Region: prfB; PRK00578 316274005725 This domain is found in peptide chain release factors; Region: PCRF; smart00937 316274005726 RF-1 domain; Region: RF-1; pfam00472 316274005727 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316274005728 Zn binding site [ion binding]; other site 316274005729 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 316274005730 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 316274005731 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316274005732 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 316274005733 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274005734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005735 putative active site [active] 316274005736 heme pocket [chemical binding]; other site 316274005737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274005738 dimer interface [polypeptide binding]; other site 316274005739 phosphorylation site [posttranslational modification] 316274005740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274005741 ATP binding site [chemical binding]; other site 316274005742 Mg2+ binding site [ion binding]; other site 316274005743 G-X-G motif; other site 316274005744 Response regulator receiver domain; Region: Response_reg; pfam00072 316274005745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274005746 active site 316274005747 phosphorylation site [posttranslational modification] 316274005748 intermolecular recognition site; other site 316274005749 dimerization interface [polypeptide binding]; other site 316274005750 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274005751 active site residue [active] 316274005752 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316274005753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005754 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274005756 DNA binding residues [nucleotide binding] 316274005757 Putative zinc-finger; Region: zf-HC2; pfam13490 316274005758 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 316274005759 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 316274005760 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 316274005761 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 316274005762 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 316274005763 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 316274005764 CRISPR-associated protein; Region: TIGR03986 316274005765 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274005766 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274005767 putative active site [active] 316274005768 putative NTP binding site [chemical binding]; other site 316274005769 putative nucleic acid binding site [nucleotide binding]; other site 316274005770 Type II intron maturase; Region: Intron_maturas2; pfam01348 316274005771 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 316274005772 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 316274005773 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 316274005774 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 316274005775 triosephosphate isomerase; Provisional; Region: PRK14565 316274005776 substrate binding site [chemical binding]; other site 316274005777 dimer interface [polypeptide binding]; other site 316274005778 catalytic triad [active] 316274005779 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 316274005780 Peptidase family M50; Region: Peptidase_M50; pfam02163 316274005781 active site 316274005782 putative substrate binding region [chemical binding]; other site 316274005783 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 316274005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274005785 S-adenosylmethionine binding site [chemical binding]; other site 316274005786 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 316274005787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274005788 RNA binding surface [nucleotide binding]; other site 316274005789 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 316274005790 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274005791 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274005792 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274005793 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 316274005794 Family description; Region: VCBS; pfam13517 316274005795 Family description; Region: VCBS; pfam13517 316274005796 Family description; Region: VCBS; pfam13517 316274005797 Family description; Region: VCBS; pfam13517 316274005798 Family description; Region: VCBS; pfam13517 316274005799 Family description; Region: VCBS; pfam13517 316274005800 Family description; Region: VCBS; pfam13517 316274005801 Family description; Region: VCBS; pfam13517 316274005802 Family description; Region: VCBS; pfam13517 316274005803 Family description; Region: VCBS; pfam13517 316274005804 Family description; Region: VCBS; pfam13517 316274005805 Family description; Region: VCBS; pfam13517 316274005806 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 316274005807 Bacterial transcriptional activator domain; Region: BTAD; smart01043 316274005808 Predicted ATPase [General function prediction only]; Region: COG3903 316274005809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005810 binding surface 316274005811 TPR motif; other site 316274005812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005814 binding surface 316274005815 TPR motif; other site 316274005816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005817 TPR repeat; Region: TPR_11; pfam13414 316274005818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005819 binding surface 316274005820 TPR motif; other site 316274005821 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005822 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005823 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005824 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005825 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005826 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005827 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274005828 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274005829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274005830 non-specific DNA binding site [nucleotide binding]; other site 316274005831 salt bridge; other site 316274005832 sequence-specific DNA binding site [nucleotide binding]; other site 316274005833 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274005834 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316274005835 conserved cys residue [active] 316274005836 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 316274005837 Peptidase M35 family; Region: M35_like; cl03449 316274005838 active site 316274005839 Zn binding site [ion binding]; other site 316274005840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274005841 S-adenosylmethionine binding site [chemical binding]; other site 316274005842 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 316274005843 Predicted helicase [General function prediction only]; Region: COG4889 316274005844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274005845 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274005848 DNA binding residues [nucleotide binding] 316274005849 putative inner membrane protein; Provisional; Region: PRK11099 316274005850 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 316274005851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274005853 TPR motif; other site 316274005854 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274005855 binding surface 316274005856 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 316274005857 putative dimer interface [polypeptide binding]; other site 316274005858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274005859 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274005860 HTH domain; Region: HTH_11; pfam08279 316274005861 WYL domain; Region: WYL; pfam13280 316274005862 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 316274005863 Beta-lactamase; Region: Beta-lactamase; pfam00144 316274005864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274005865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274005866 Coenzyme A binding pocket [chemical binding]; other site 316274005867 phosphoenolpyruvate synthase; Validated; Region: PRK06241 316274005868 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316274005869 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316274005870 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 316274005871 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 316274005872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274005873 ATP binding site [chemical binding]; other site 316274005874 putative Mg++ binding site [ion binding]; other site 316274005875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274005876 ATP-binding site [chemical binding]; other site 316274005877 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 316274005878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274005879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316274005880 Walker A motif; other site 316274005881 ATP binding site [chemical binding]; other site 316274005882 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274005883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274005884 ATP binding site [chemical binding]; other site 316274005885 putative Mg++ binding site [ion binding]; other site 316274005886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274005887 nucleotide binding region [chemical binding]; other site 316274005888 ATP-binding site [chemical binding]; other site 316274005889 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 316274005890 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 316274005891 putative active site [active] 316274005892 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005893 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 316274005894 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 316274005895 PAS fold; Region: PAS_4; pfam08448 316274005896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005897 putative active site [active] 316274005898 heme pocket [chemical binding]; other site 316274005899 PAS domain S-box; Region: sensory_box; TIGR00229 316274005900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274005901 PAS domain; Region: PAS_9; pfam13426 316274005902 putative active site [active] 316274005903 heme pocket [chemical binding]; other site 316274005904 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274005905 putative cation:proton antiport protein; Provisional; Region: PRK10669 316274005906 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316274005907 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274005908 TrkA-N domain; Region: TrkA_N; pfam02254 316274005909 TrkA-C domain; Region: TrkA_C; pfam02080 316274005910 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274005911 MarR family; Region: MarR; pfam01047 316274005912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005914 Cytochrome P450; Region: p450; cl12078 316274005915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274005916 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005917 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274005918 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274005919 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 316274005920 protein-splicing catalytic site; other site 316274005921 thioester formation/cholesterol transfer; other site 316274005922 Pretoxin HINT domain; Region: PT-HINT; pfam07591 316274005923 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 316274005924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 316274005925 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 316274005926 DNA photolyase; Region: DNA_photolyase; pfam00875 316274005927 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 316274005928 active site 316274005929 active site 316274005930 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 316274005931 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005932 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274005933 Phage Tail Collar Domain; Region: Collar; pfam07484 316274005934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274005935 WYL domain; Region: WYL; pfam13280 316274005936 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 316274005937 hydrophobic ligand binding site; other site 316274005938 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 316274005939 putative active site [active] 316274005940 META domain; Region: META; pfam03724 316274005941 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005942 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005943 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005944 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316274005945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274005946 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274005947 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 316274005948 CHAT domain; Region: CHAT; pfam12770 316274005949 CHAT domain; Region: CHAT; cl17868 316274005950 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274005951 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005952 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274005953 Phage Tail Collar Domain; Region: Collar; pfam07484 316274005954 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 316274005955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 316274005956 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274005957 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274005958 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274005959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274005960 DNA binding residues [nucleotide binding] 316274005961 dimerization interface [polypeptide binding]; other site 316274005962 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 316274005963 active site 316274005964 catalytic triad [active] 316274005965 oxyanion hole [active] 316274005966 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005967 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005968 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 316274005969 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005970 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005971 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274005972 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274005973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274005974 putative substrate translocation pore; other site 316274005975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274005976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274005977 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274005978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274005979 putative DNA binding site [nucleotide binding]; other site 316274005980 putative Zn2+ binding site [ion binding]; other site 316274005981 dimerization interface [polypeptide binding]; other site 316274005982 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 316274005983 4Fe-4S binding domain; Region: Fer4; pfam00037 316274005984 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 316274005985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274005986 NAD(P) binding site [chemical binding]; other site 316274005987 active site 316274005988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274005989 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 316274005990 dimer interface [polypeptide binding]; other site 316274005991 substrate binding site [chemical binding]; other site 316274005992 metal binding site [ion binding]; metal-binding site 316274005993 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 316274005994 Citrate synthase; Region: Citrate_synt; pfam00285 316274005995 oxalacetate binding site [chemical binding]; other site 316274005996 citrylCoA binding site [chemical binding]; other site 316274005997 coenzyme A binding site [chemical binding]; other site 316274005998 catalytic triad [active] 316274005999 acyl-CoA synthetase; Validated; Region: PRK09192 316274006000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274006001 acyl-activating enzyme (AAE) consensus motif; other site 316274006002 AMP binding site [chemical binding]; other site 316274006003 active site 316274006004 CoA binding site [chemical binding]; other site 316274006005 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006006 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274006007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274006008 active site 316274006009 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274006010 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274006011 putative NADP binding site [chemical binding]; other site 316274006012 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274006013 active site 316274006014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006015 Condensation domain; Region: Condensation; pfam00668 316274006016 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274006017 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006018 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006019 acyl-activating enzyme (AAE) consensus motif; other site 316274006020 AMP binding site [chemical binding]; other site 316274006021 Condensation domain; Region: Condensation; pfam00668 316274006022 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006023 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 316274006024 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274006025 HTH domain; Region: HTH_11; pfam08279 316274006026 WYL domain; Region: WYL; pfam13280 316274006027 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274006028 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 316274006029 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 316274006030 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 316274006031 histidinol dehydrogenase; Region: hisD; TIGR00069 316274006032 NAD binding site [chemical binding]; other site 316274006033 dimerization interface [polypeptide binding]; other site 316274006034 product binding site; other site 316274006035 substrate binding site [chemical binding]; other site 316274006036 zinc binding site [ion binding]; other site 316274006037 catalytic residues [active] 316274006038 PrcB C-terminal; Region: PrcB_C; pfam14343 316274006039 Cytochrome P450; Region: p450; cl12078 316274006040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274006041 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 316274006042 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 316274006043 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 316274006044 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 316274006045 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 316274006046 hypothetical protein; Validated; Region: PRK06201 316274006047 Ycf48-like protein; Provisional; Region: PRK13684 316274006048 Ycf48-like protein; Provisional; Region: PRK13684 316274006049 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 316274006050 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 316274006051 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 316274006052 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 316274006053 active site 316274006054 non-prolyl cis peptide bond; other site 316274006055 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 316274006056 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 316274006057 dimerization interface [polypeptide binding]; other site 316274006058 NAD binding site [chemical binding]; other site 316274006059 ligand binding site [chemical binding]; other site 316274006060 catalytic site [active] 316274006061 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274006062 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274006063 active site 316274006064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274006065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274006066 putative substrate translocation pore; other site 316274006067 aconitate hydratase; Validated; Region: PRK09277 316274006068 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 316274006069 substrate binding site [chemical binding]; other site 316274006070 ligand binding site [chemical binding]; other site 316274006071 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 316274006072 substrate binding site [chemical binding]; other site 316274006073 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 316274006074 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006075 acyl-activating enzyme (AAE) consensus motif; other site 316274006076 AMP binding site [chemical binding]; other site 316274006077 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 316274006078 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 316274006079 dimer interface [polypeptide binding]; other site 316274006080 Citrate synthase; Region: Citrate_synt; pfam00285 316274006081 active site 316274006082 citrylCoA binding site [chemical binding]; other site 316274006083 oxalacetate/citrate binding site [chemical binding]; other site 316274006084 coenzyme A binding site [chemical binding]; other site 316274006085 catalytic triad [active] 316274006086 hypothetical protein; Provisional; Region: PRK10281 316274006087 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274006088 multiple promoter invertase; Provisional; Region: mpi; PRK13413 316274006089 catalytic residues [active] 316274006090 catalytic nucleophile [active] 316274006091 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274006092 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274006093 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274006094 Synaptic Site I dimer interface [polypeptide binding]; other site 316274006095 DNA binding site [nucleotide binding] 316274006096 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 316274006097 DNA-binding interface [nucleotide binding]; DNA binding site 316274006098 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 316274006099 putative active site [active] 316274006100 Cna protein B-type domain; Region: Cna_B_2; pfam13715 316274006101 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274006102 RHS Repeat; Region: RHS_repeat; cl11982 316274006103 RHS Repeat; Region: RHS_repeat; cl11982 316274006104 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274006105 RHS Repeat; Region: RHS_repeat; cl11982 316274006106 RHS Repeat; Region: RHS_repeat; pfam05593 316274006107 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274006108 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 316274006109 protein-splicing catalytic site; other site 316274006110 thioester formation/cholesterol transfer; other site 316274006111 Pretoxin HINT domain; Region: PT-HINT; pfam07591 316274006112 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 316274006113 NB-ARC domain; Region: NB-ARC; pfam00931 316274006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006115 TPR motif; other site 316274006116 binding surface 316274006117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006119 binding surface 316274006120 TPR motif; other site 316274006121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006124 binding surface 316274006125 TPR motif; other site 316274006126 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006127 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006129 binding surface 316274006130 TPR motif; other site 316274006131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006132 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274006133 MULE transposase domain; Region: MULE; pfam10551 316274006134 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316274006135 Putative transposase; Region: Y2_Tnp; pfam04986 316274006136 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274006137 DNA binding site [nucleotide binding] 316274006138 active site 316274006139 Int/Topo IB signature motif; other site 316274006140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274006141 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274006142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274006143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274006144 non-specific DNA binding site [nucleotide binding]; other site 316274006145 salt bridge; other site 316274006146 sequence-specific DNA binding site [nucleotide binding]; other site 316274006147 Transposase domain (DUF772); Region: DUF772; pfam05598 316274006148 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274006149 Leucine rich repeat; Region: LRR_8; pfam13855 316274006150 Leucine rich repeat; Region: LRR_8; pfam13855 316274006151 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274006152 Leucine-rich repeats; other site 316274006153 Substrate binding site [chemical binding]; other site 316274006154 Leucine rich repeat; Region: LRR_8; pfam13855 316274006155 response regulator PleD; Reviewed; Region: pleD; PRK09581 316274006156 short chain dehydrogenase; Provisional; Region: PRK06172 316274006157 classical (c) SDRs; Region: SDR_c; cd05233 316274006158 NAD(P) binding site [chemical binding]; other site 316274006159 active site 316274006160 CCC1-related family of proteins; Region: CCC1_like; cl00278 316274006161 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 316274006162 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274006163 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 316274006164 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 316274006165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274006166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274006167 Coenzyme A binding pocket [chemical binding]; other site 316274006168 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 316274006169 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274006170 intersubunit interface [polypeptide binding]; other site 316274006171 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274006172 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316274006173 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274006174 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274006175 ABC-ATPase subunit interface; other site 316274006176 dimer interface [polypeptide binding]; other site 316274006177 putative PBP binding regions; other site 316274006178 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274006179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 316274006180 Integrase core domain; Region: rve; pfam00665 316274006181 Integrase core domain; Region: rve_3; pfam13683 316274006182 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274006183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006184 S-adenosylmethionine binding site [chemical binding]; other site 316274006185 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 316274006186 metal binding site 2 [ion binding]; metal-binding site 316274006187 putative DNA binding helix; other site 316274006188 metal binding site 1 [ion binding]; metal-binding site 316274006189 dimer interface [polypeptide binding]; other site 316274006190 structural Zn2+ binding site [ion binding]; other site 316274006191 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274006192 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 316274006193 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 316274006194 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 316274006195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 316274006196 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274006197 G1 box; other site 316274006198 GTP/Mg2+ binding site [chemical binding]; other site 316274006199 G2 box; other site 316274006200 G3 box; other site 316274006201 Switch II region; other site 316274006202 G4 box; other site 316274006203 G5 box; other site 316274006204 Nucleoside recognition; Region: Gate; pfam07670 316274006205 Nucleoside recognition; Region: Gate; pfam07670 316274006206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274006207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006208 S-adenosylmethionine binding site [chemical binding]; other site 316274006209 electron transport complex protein RnfC; Provisional; Region: PRK05035 316274006210 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274006211 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274006212 homodimer interface [polypeptide binding]; other site 316274006213 active site 316274006214 TDP-binding site; other site 316274006215 acceptor substrate-binding pocket; other site 316274006216 RibD C-terminal domain; Region: RibD_C; cl17279 316274006217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274006218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274006219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274006220 Walker A/P-loop; other site 316274006221 ATP binding site [chemical binding]; other site 316274006222 Q-loop/lid; other site 316274006223 ABC transporter signature motif; other site 316274006224 Walker B; other site 316274006225 D-loop; other site 316274006226 H-loop/switch region; other site 316274006227 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274006228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274006229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274006230 Walker A/P-loop; other site 316274006231 ATP binding site [chemical binding]; other site 316274006232 Q-loop/lid; other site 316274006233 ABC transporter signature motif; other site 316274006234 Walker B; other site 316274006235 D-loop; other site 316274006236 H-loop/switch region; other site 316274006237 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 316274006238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274006239 inhibitor-cofactor binding pocket; inhibition site 316274006240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274006241 catalytic residue [active] 316274006242 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274006243 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274006244 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006245 acyl-activating enzyme (AAE) consensus motif; other site 316274006246 AMP binding site [chemical binding]; other site 316274006247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006248 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 316274006249 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006250 acyl-activating enzyme (AAE) consensus motif; other site 316274006251 AMP binding site [chemical binding]; other site 316274006252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006253 Condensation domain; Region: Condensation; pfam00668 316274006254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274006256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006257 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274006258 G4 box; other site 316274006259 Condensation domain; Region: Condensation; pfam00668 316274006260 G5 box; other site 316274006261 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006262 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274006263 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006264 acyl-activating enzyme (AAE) consensus motif; other site 316274006265 AMP binding site [chemical binding]; other site 316274006266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274006268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006269 Condensation domain; Region: Condensation; pfam00668 316274006270 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006271 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 316274006272 Condensation domain; Region: Condensation; pfam00668 316274006273 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006275 acyl-activating enzyme (AAE) consensus motif; other site 316274006276 AMP binding site [chemical binding]; other site 316274006277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006278 YtkA-like; Region: YtkA; pfam13115 316274006279 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274006280 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274006281 intersubunit interface [polypeptide binding]; other site 316274006282 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274006283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 316274006284 dimer interface [polypeptide binding]; other site 316274006285 putative PBP binding regions; other site 316274006286 ABC-ATPase subunit interface; other site 316274006287 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274006288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274006289 Walker A/P-loop; other site 316274006290 ATP binding site [chemical binding]; other site 316274006291 Q-loop/lid; other site 316274006292 ABC transporter signature motif; other site 316274006293 Walker B; other site 316274006294 D-loop; other site 316274006295 H-loop/switch region; other site 316274006296 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274006297 conserved cys residue [active] 316274006298 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274006299 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274006300 Walker A/P-loop; other site 316274006301 ATP binding site [chemical binding]; other site 316274006302 Q-loop/lid; other site 316274006303 ABC transporter signature motif; other site 316274006304 Walker B; other site 316274006305 D-loop; other site 316274006306 H-loop/switch region; other site 316274006307 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274006308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274006309 ABC-ATPase subunit interface; other site 316274006310 dimer interface [polypeptide binding]; other site 316274006311 putative PBP binding regions; other site 316274006312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274006313 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 316274006314 intersubunit interface [polypeptide binding]; other site 316274006315 hypothetical protein; Provisional; Region: PRK08317 316274006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006317 S-adenosylmethionine binding site [chemical binding]; other site 316274006318 Cut8; Region: Cut8; pfam08559 316274006319 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 316274006320 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 316274006321 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 316274006322 active site 316274006323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274006324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006325 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 316274006326 putative NAD(P) binding site [chemical binding]; other site 316274006327 active site 316274006328 putative substrate binding site [chemical binding]; other site 316274006329 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 316274006330 Condensation domain; Region: Condensation; pfam00668 316274006331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006332 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006333 acyl-activating enzyme (AAE) consensus motif; other site 316274006334 AMP binding site [chemical binding]; other site 316274006335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006336 Condensation domain; Region: Condensation; pfam00668 316274006337 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006338 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006339 acyl-activating enzyme (AAE) consensus motif; other site 316274006340 AMP binding site [chemical binding]; other site 316274006341 Condensation domain; Region: Condensation; pfam00668 316274006342 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274006343 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274006344 acyl-CoA synthetase; Validated; Region: PRK05850 316274006345 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 316274006346 acyl-activating enzyme (AAE) consensus motif; other site 316274006347 active site 316274006348 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274006349 Condensation domain; Region: Condensation; pfam00668 316274006350 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274006351 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274006352 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006353 acyl-activating enzyme (AAE) consensus motif; other site 316274006354 AMP binding site [chemical binding]; other site 316274006355 Condensation domain; Region: Condensation; pfam00668 316274006356 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 316274006357 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274006358 acyl-activating enzyme (AAE) consensus motif; other site 316274006359 AMP binding site [chemical binding]; other site 316274006360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274006361 MbtH-like protein; Region: MbtH; cl01279 316274006362 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274006363 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316274006364 intersubunit interface [polypeptide binding]; other site 316274006365 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316274006366 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274006367 ABC-ATPase subunit interface; other site 316274006368 dimer interface [polypeptide binding]; other site 316274006369 putative PBP binding regions; other site 316274006370 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316274006371 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316274006372 Walker A/P-loop; other site 316274006373 ATP binding site [chemical binding]; other site 316274006374 Q-loop/lid; other site 316274006375 ABC transporter signature motif; other site 316274006376 Walker B; other site 316274006377 D-loop; other site 316274006378 H-loop/switch region; other site 316274006379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274006380 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 316274006381 putative switch regulator; other site 316274006382 non-specific DNA interactions [nucleotide binding]; other site 316274006383 DNA binding site [nucleotide binding] 316274006384 sequence specific DNA binding site [nucleotide binding]; other site 316274006385 putative cAMP binding site [chemical binding]; other site 316274006386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274006387 sequence-specific DNA binding site [nucleotide binding]; other site 316274006388 salt bridge; other site 316274006389 AAA ATPase domain; Region: AAA_16; pfam13191 316274006390 Predicted ATPase [General function prediction only]; Region: COG3903 316274006391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006393 binding surface 316274006394 TPR motif; other site 316274006395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006398 binding surface 316274006399 TPR motif; other site 316274006400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006401 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 316274006402 Chloramphenicol acetyltransferase; Region: CAT; smart01059 316274006403 Agrin NtA domain; Region: NtA; pfam03146 316274006404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274006405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274006406 TM-ABC transporter signature motif; other site 316274006407 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274006408 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274006409 TM-ABC transporter signature motif; other site 316274006410 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 316274006411 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316274006412 Walker A/P-loop; other site 316274006413 ATP binding site [chemical binding]; other site 316274006414 Q-loop/lid; other site 316274006415 ABC transporter signature motif; other site 316274006416 Walker B; other site 316274006417 D-loop; other site 316274006418 H-loop/switch region; other site 316274006419 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 316274006420 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274006421 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 316274006422 putative ligand binding site [chemical binding]; other site 316274006423 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274006424 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 316274006425 putative ligand binding site [chemical binding]; other site 316274006426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274006427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274006428 dimerization interface [polypeptide binding]; other site 316274006429 Histidine kinase; Region: His_kinase; pfam06580 316274006430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006431 ATP binding site [chemical binding]; other site 316274006432 Mg2+ binding site [ion binding]; other site 316274006433 G-X-G motif; other site 316274006434 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006436 active site 316274006437 phosphorylation site [posttranslational modification] 316274006438 intermolecular recognition site; other site 316274006439 dimerization interface [polypeptide binding]; other site 316274006440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274006441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274006442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274006443 Rrf2 family protein; Region: rrf2_super; TIGR00738 316274006444 Transcriptional regulator; Region: Rrf2; pfam02082 316274006445 Transcriptional regulator; Region: Rrf2; cl17282 316274006446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274006447 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274006448 putative substrate translocation pore; other site 316274006449 AAA ATPase domain; Region: AAA_16; pfam13191 316274006450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006451 S-adenosylmethionine binding site [chemical binding]; other site 316274006452 TMAO/DMSO reductase; Reviewed; Region: PRK05363 316274006453 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274006454 Moco binding site; other site 316274006455 metal coordination site [ion binding]; other site 316274006456 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 316274006457 Cellulose binding domain; Region: CBM_2; pfam00553 316274006458 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 316274006459 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 316274006460 PAS domain; Region: PAS_9; pfam13426 316274006461 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274006462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274006463 PAS fold; Region: PAS_3; pfam08447 316274006464 putative active site [active] 316274006465 heme pocket [chemical binding]; other site 316274006466 PAS domain S-box; Region: sensory_box; TIGR00229 316274006467 PAS domain S-box; Region: sensory_box; TIGR00229 316274006468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274006469 putative active site [active] 316274006470 heme pocket [chemical binding]; other site 316274006471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274006472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274006473 dimer interface [polypeptide binding]; other site 316274006474 phosphorylation site [posttranslational modification] 316274006475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006476 ATP binding site [chemical binding]; other site 316274006477 G-X-G motif; other site 316274006478 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274006479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006480 active site 316274006481 phosphorylation site [posttranslational modification] 316274006482 intermolecular recognition site; other site 316274006483 dimerization interface [polypeptide binding]; other site 316274006484 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 316274006485 Trp docking motif [polypeptide binding]; other site 316274006486 Cellulose binding domain; Region: CBM_2; pfam00553 316274006487 AAA domain; Region: AAA_17; pfam13207 316274006488 AAA domain; Region: AAA_18; pfam13238 316274006489 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316274006490 von Willebrand factor; Region: vWF_A; pfam12450 316274006491 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274006492 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 316274006493 metal ion-dependent adhesion site (MIDAS); other site 316274006494 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 316274006495 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 316274006496 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274006497 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274006498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274006499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274006500 dimer interface [polypeptide binding]; other site 316274006501 phosphorylation site [posttranslational modification] 316274006502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006503 ATP binding site [chemical binding]; other site 316274006504 Mg2+ binding site [ion binding]; other site 316274006505 G-X-G motif; other site 316274006506 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006508 active site 316274006509 phosphorylation site [posttranslational modification] 316274006510 intermolecular recognition site; other site 316274006511 dimerization interface [polypeptide binding]; other site 316274006512 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274006513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006514 active site 316274006515 phosphorylation site [posttranslational modification] 316274006516 intermolecular recognition site; other site 316274006517 dimerization interface [polypeptide binding]; other site 316274006518 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006520 active site 316274006521 phosphorylation site [posttranslational modification] 316274006522 intermolecular recognition site; other site 316274006523 dimerization interface [polypeptide binding]; other site 316274006524 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 316274006525 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316274006526 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 316274006527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006528 S-adenosylmethionine binding site [chemical binding]; other site 316274006529 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006531 active site 316274006532 phosphorylation site [posttranslational modification] 316274006533 intermolecular recognition site; other site 316274006534 dimerization interface [polypeptide binding]; other site 316274006535 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274006536 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 316274006537 putative active site [active] 316274006538 putative metal binding site [ion binding]; other site 316274006539 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274006540 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274006541 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274006542 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006543 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006544 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 316274006545 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 316274006546 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274006547 amidase catalytic site [active] 316274006548 Zn binding residues [ion binding]; other site 316274006549 substrate binding site [chemical binding]; other site 316274006550 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274006551 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006552 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006553 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274006554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006555 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274006556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274006557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006558 active site 316274006559 phosphorylation site [posttranslational modification] 316274006560 intermolecular recognition site; other site 316274006561 dimerization interface [polypeptide binding]; other site 316274006562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274006563 DNA binding site [nucleotide binding] 316274006564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274006565 Predicted ATPase [General function prediction only]; Region: COG3903 316274006566 Walker A motif; other site 316274006567 ATP binding site [chemical binding]; other site 316274006568 Walker B motif; other site 316274006569 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006570 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 316274006571 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 316274006572 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274006573 active site 316274006574 catalytic triad [active] 316274006575 Predicted ATPase [General function prediction only]; Region: COG3903 316274006576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006577 Predicted ATPase [General function prediction only]; Region: COG3903 316274006578 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 316274006579 catalytic residues [active] 316274006580 Response regulator receiver domain; Region: Response_reg; pfam00072 316274006581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006582 active site 316274006583 phosphorylation site [posttranslational modification] 316274006584 intermolecular recognition site; other site 316274006585 dimerization interface [polypeptide binding]; other site 316274006586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274006587 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274006588 GAF domain; Region: GAF; cl17456 316274006589 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274006590 GAF domain; Region: GAF_3; pfam13492 316274006591 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316274006592 cyclase homology domain; Region: CHD; cd07302 316274006593 nucleotidyl binding site; other site 316274006594 metal binding site [ion binding]; metal-binding site 316274006595 dimer interface [polypeptide binding]; other site 316274006596 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 316274006597 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 316274006598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274006599 FeS/SAM binding site; other site 316274006600 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274006601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274006602 S-adenosylmethionine binding site [chemical binding]; other site 316274006603 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 316274006604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274006605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274006606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274006607 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274006608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274006609 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274006610 Methyltransferase domain; Region: Methyltransf_11; pfam08241 316274006611 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006612 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006613 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006614 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006615 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006616 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316274006617 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 316274006618 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006619 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316274006620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274006621 Histidine kinase; Region: HisKA_3; pfam07730 316274006622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006623 ATP binding site [chemical binding]; other site 316274006624 Mg2+ binding site [ion binding]; other site 316274006625 G-X-G motif; other site 316274006626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274006627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006628 active site 316274006629 phosphorylation site [posttranslational modification] 316274006630 intermolecular recognition site; other site 316274006631 dimerization interface [polypeptide binding]; other site 316274006632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274006633 DNA binding residues [nucleotide binding] 316274006634 dimerization interface [polypeptide binding]; other site 316274006635 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274006636 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 316274006637 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316274006638 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 316274006639 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316274006640 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 316274006641 putative sugar binding site [chemical binding]; other site 316274006642 catalytic residues [active] 316274006643 Glyco_18 domain; Region: Glyco_18; smart00636 316274006644 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274006645 active site 316274006646 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274006647 sugar binding site [chemical binding]; other site 316274006648 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274006649 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274006650 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 316274006651 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 316274006652 PKC phosphorylation site [posttranslational modification]; other site 316274006653 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 316274006654 Predicted integral membrane protein [Function unknown]; Region: COG5617 316274006655 putative glycosyl transferase; Provisional; Region: PRK10063 316274006656 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274006657 Ligand binding site; other site 316274006658 Ligand binding site; other site 316274006659 Ligand binding site; other site 316274006660 Putative Catalytic site; other site 316274006661 DXD motif; other site 316274006662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274006663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274006664 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274006665 anti sigma factor interaction site; other site 316274006666 regulatory phosphorylation site [posttranslational modification]; other site 316274006667 GAF domain; Region: GAF; cl17456 316274006668 GAF domain; Region: GAF_2; pfam13185 316274006669 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274006670 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274006671 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274006672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316274006673 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274006674 anti sigma factor interaction site; other site 316274006675 regulatory phosphorylation site [posttranslational modification]; other site 316274006676 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 316274006677 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274006678 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274006679 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274006680 putative trimer interface [polypeptide binding]; other site 316274006681 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274006682 putative trimer interface [polypeptide binding]; other site 316274006683 putative trimer interface [polypeptide binding]; other site 316274006684 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 316274006685 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274006686 Predicted helicase [General function prediction only]; Region: COG4889 316274006687 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274006688 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274006689 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274006690 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274006691 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274006692 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274006693 HEAT repeats; Region: HEAT_2; pfam13646 316274006694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274006695 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 316274006696 putative NAD(P) binding site [chemical binding]; other site 316274006697 active site 316274006698 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274006699 active site 316274006700 catalytic triad [active] 316274006701 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 316274006702 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 316274006703 ligand binding site [chemical binding]; other site 316274006704 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 316274006705 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274006706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274006707 non-specific DNA binding site [nucleotide binding]; other site 316274006708 salt bridge; other site 316274006709 sequence-specific DNA binding site [nucleotide binding]; other site 316274006710 Predicted ATPase [General function prediction only]; Region: COG3903 316274006711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274006712 TPR motif; other site 316274006713 binding surface 316274006714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006715 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006717 binding surface 316274006718 TPR motif; other site 316274006719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006720 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274006721 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 316274006722 active site 316274006723 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 316274006724 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 316274006725 Cache domain; Region: Cache_1; pfam02743 316274006726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274006727 dimerization interface [polypeptide binding]; other site 316274006728 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274006729 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 316274006730 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 316274006731 putative ligand binding site [chemical binding]; other site 316274006732 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 316274006733 homotrimer interaction site [polypeptide binding]; other site 316274006734 putative active site [active] 316274006735 Cupin domain; Region: Cupin_2; pfam07883 316274006736 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 316274006737 dimer interface [polypeptide binding]; other site 316274006738 ligand binding site [chemical binding]; other site 316274006739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006740 TPR motif; other site 316274006741 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316274006742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274006743 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 316274006744 putative active site [active] 316274006745 putative catalytic triad [active] 316274006746 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316274006747 HSP70 interaction site [polypeptide binding]; other site 316274006748 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 316274006749 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 316274006750 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274006751 DinB superfamily; Region: DinB_2; pfam12867 316274006752 DinB family; Region: DinB; cl17821 316274006753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274006754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274006755 Cytochrome P450; Region: p450; pfam00067 316274006756 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 316274006757 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 316274006758 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 316274006759 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 316274006760 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 316274006761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 316274006762 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 316274006763 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 316274006764 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 316274006765 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274006766 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274006767 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 316274006768 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 316274006769 trimer interface [polypeptide binding]; other site 316274006770 putative metal binding site [ion binding]; other site 316274006771 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316274006772 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 316274006773 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 316274006774 putative active site [active] 316274006775 putative metal binding site [ion binding]; other site 316274006776 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 316274006777 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316274006778 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 316274006779 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274006780 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 316274006781 putative acyl-acceptor binding pocket; other site 316274006782 histidyl-tRNA synthetase; Region: hisS; TIGR00442 316274006783 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 316274006784 dimer interface [polypeptide binding]; other site 316274006785 motif 1; other site 316274006786 active site 316274006787 motif 2; other site 316274006788 motif 3; other site 316274006789 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 316274006790 anticodon binding site; other site 316274006791 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316274006792 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316274006793 peptide binding site [polypeptide binding]; other site 316274006794 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 316274006795 aromatic arch; other site 316274006796 DCoH dimer interaction site [polypeptide binding]; other site 316274006797 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 316274006798 DCoH tetramer interaction site [polypeptide binding]; other site 316274006799 substrate binding site [chemical binding]; other site 316274006800 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 316274006801 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 316274006802 putative ADP-binding pocket [chemical binding]; other site 316274006803 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 316274006804 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316274006805 cyclase homology domain; Region: CHD; cd07302 316274006806 nucleotidyl binding site; other site 316274006807 metal binding site [ion binding]; metal-binding site 316274006808 dimer interface [polypeptide binding]; other site 316274006809 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274006810 cyclase homology domain; Region: CHD; cd07302 316274006811 nucleotidyl binding site; other site 316274006812 metal binding site [ion binding]; metal-binding site 316274006813 dimer interface [polypeptide binding]; other site 316274006814 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 316274006815 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 316274006816 AAA ATPase domain; Region: AAA_16; pfam13191 316274006817 NACHT domain; Region: NACHT; pfam05729 316274006818 cyclase homology domain; Region: CHD; cd07302 316274006819 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274006820 nucleotidyl binding site; other site 316274006821 metal binding site [ion binding]; metal-binding site 316274006822 dimer interface [polypeptide binding]; other site 316274006823 cyclase homology domain; Region: CHD; cd07302 316274006824 nucleotidyl binding site; other site 316274006825 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274006826 dimer interface [polypeptide binding]; other site 316274006827 metal binding site [ion binding]; metal-binding site 316274006828 AAA ATPase domain; Region: AAA_16; pfam13191 316274006829 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006832 binding surface 316274006833 TPR motif; other site 316274006834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006836 AAA ATPase domain; Region: AAA_16; pfam13191 316274006837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274006839 TPR motif; other site 316274006840 binding surface 316274006841 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006843 binding surface 316274006844 TPR motif; other site 316274006845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006849 binding surface 316274006850 TPR motif; other site 316274006851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006852 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274006854 TPR motif; other site 316274006855 binding surface 316274006856 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 316274006857 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 316274006858 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 316274006859 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274006860 GAF domain; Region: GAF_3; pfam13492 316274006861 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274006862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274006863 dimer interface [polypeptide binding]; other site 316274006864 phosphorylation site [posttranslational modification] 316274006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006866 ATP binding site [chemical binding]; other site 316274006867 Mg2+ binding site [ion binding]; other site 316274006868 G-X-G motif; other site 316274006869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274006870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006871 active site 316274006872 phosphorylation site [posttranslational modification] 316274006873 intermolecular recognition site; other site 316274006874 dimerization interface [polypeptide binding]; other site 316274006875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274006876 DNA binding site [nucleotide binding] 316274006877 CoA-transferase family III; Region: CoA_transf_3; pfam02515 316274006878 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 316274006879 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 316274006880 CoA-transferase family III; Region: CoA_transf_3; pfam02515 316274006881 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316274006882 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 316274006883 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274006884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274006885 dimer interface [polypeptide binding]; other site 316274006886 conserved gate region; other site 316274006887 putative PBP binding loops; other site 316274006888 ABC-ATPase subunit interface; other site 316274006889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274006890 dimer interface [polypeptide binding]; other site 316274006891 conserved gate region; other site 316274006892 putative PBP binding loops; other site 316274006893 ABC-ATPase subunit interface; other site 316274006894 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274006895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274006896 Walker A/P-loop; other site 316274006897 ATP binding site [chemical binding]; other site 316274006898 Q-loop/lid; other site 316274006899 ABC transporter signature motif; other site 316274006900 Walker B; other site 316274006901 D-loop; other site 316274006902 H-loop/switch region; other site 316274006903 TOBE domain; Region: TOBE_2; pfam08402 316274006904 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 316274006905 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 316274006906 putative ligand binding site [chemical binding]; other site 316274006907 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316274006908 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316274006909 catalytic residue [active] 316274006910 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274006911 amidase catalytic site [active] 316274006912 Zn binding residues [ion binding]; other site 316274006913 substrate binding site [chemical binding]; other site 316274006914 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 316274006915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274006916 Cytochrome P450; Region: p450; cl12078 316274006917 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 316274006918 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 316274006919 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 316274006920 Ligand Binding Site [chemical binding]; other site 316274006921 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316274006922 GAF domain; Region: GAF_3; pfam13492 316274006923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274006924 dimer interface [polypeptide binding]; other site 316274006925 phosphorylation site [posttranslational modification] 316274006926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274006927 ATP binding site [chemical binding]; other site 316274006928 Mg2+ binding site [ion binding]; other site 316274006929 G-X-G motif; other site 316274006930 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 316274006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006932 active site 316274006933 phosphorylation site [posttranslational modification] 316274006934 intermolecular recognition site; other site 316274006935 dimerization interface [polypeptide binding]; other site 316274006936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274006937 DNA binding site [nucleotide binding] 316274006938 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 316274006939 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 316274006940 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274006941 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 316274006942 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274006943 Double zinc ribbon; Region: DZR; pfam12773 316274006944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274006945 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274006946 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 316274006947 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 316274006948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 316274006949 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 316274006950 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 316274006951 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 316274006952 putative nucleotide binding site [chemical binding]; other site 316274006953 putative substrate binding site [chemical binding]; other site 316274006954 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316274006955 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 316274006956 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 316274006957 substrate binding site [chemical binding]; other site 316274006958 hexamer interface [polypeptide binding]; other site 316274006959 metal binding site [ion binding]; metal-binding site 316274006960 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 316274006961 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 316274006962 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316274006963 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 316274006964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274006965 Walker A motif; other site 316274006966 ATP binding site [chemical binding]; other site 316274006967 Walker B motif; other site 316274006968 arginine finger; other site 316274006969 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 316274006970 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274006971 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 316274006972 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 316274006973 substrate-cofactor binding pocket; other site 316274006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274006975 catalytic residue [active] 316274006976 Oligomerisation domain; Region: Oligomerisation; pfam02410 316274006977 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316274006978 DNA-binding site [nucleotide binding]; DNA binding site 316274006979 RNA-binding motif; other site 316274006980 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316274006981 RNA binding site [nucleotide binding]; other site 316274006982 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 316274006983 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274006984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274006985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274006986 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 316274006987 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 316274006988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274006989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274006990 active site 316274006991 phosphorylation site [posttranslational modification] 316274006992 intermolecular recognition site; other site 316274006993 dimerization interface [polypeptide binding]; other site 316274006994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274006995 DNA binding site [nucleotide binding] 316274006996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274006997 dimerization interface [polypeptide binding]; other site 316274006998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274006999 dimer interface [polypeptide binding]; other site 316274007000 phosphorylation site [posttranslational modification] 316274007001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007002 ATP binding site [chemical binding]; other site 316274007003 Mg2+ binding site [ion binding]; other site 316274007004 G-X-G motif; other site 316274007005 CAAX protease self-immunity; Region: Abi; pfam02517 316274007006 L-aspartate oxidase; Provisional; Region: PRK06175 316274007007 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 316274007008 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316274007009 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 316274007010 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 316274007011 active site 316274007012 (T/H)XGH motif; other site 316274007013 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 316274007014 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 316274007015 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274007016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274007018 DNA binding residues [nucleotide binding] 316274007019 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274007020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274007021 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 316274007022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274007023 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274007024 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 316274007025 HAMP domain; Region: HAMP; pfam00672 316274007026 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007027 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274007028 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 316274007029 putative ligand binding site [chemical binding]; other site 316274007030 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274007031 Cytochrome P450; Region: p450; pfam00067 316274007032 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316274007033 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316274007034 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 316274007035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274007036 GAF domain; Region: GAF; pfam01590 316274007037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274007038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274007039 dimer interface [polypeptide binding]; other site 316274007040 phosphorylation site [posttranslational modification] 316274007041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007042 ATP binding site [chemical binding]; other site 316274007043 Mg2+ binding site [ion binding]; other site 316274007044 G-X-G motif; other site 316274007045 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 316274007046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274007047 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 316274007048 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 316274007049 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 316274007050 catalytic triad [active] 316274007051 Right handed beta helix region; Region: Beta_helix; pfam13229 316274007052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316274007053 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 316274007054 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274007055 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316274007056 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 316274007057 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 316274007058 [4Fe-4S] binding site [ion binding]; other site 316274007059 molybdopterin cofactor binding site; other site 316274007060 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 316274007061 molybdopterin cofactor binding site; other site 316274007062 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 316274007063 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 316274007064 active site 316274007065 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 316274007066 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316274007067 NMT1-like family; Region: NMT1_2; pfam13379 316274007068 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316274007069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274007070 dimer interface [polypeptide binding]; other site 316274007071 conserved gate region; other site 316274007072 putative PBP binding loops; other site 316274007073 ABC-ATPase subunit interface; other site 316274007074 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316274007075 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 316274007076 Walker A/P-loop; other site 316274007077 ATP binding site [chemical binding]; other site 316274007078 Q-loop/lid; other site 316274007079 ABC transporter signature motif; other site 316274007080 Walker B; other site 316274007081 D-loop; other site 316274007082 H-loop/switch region; other site 316274007083 hypothetical protein; Provisional; Region: PRK06753 316274007084 hypothetical protein; Provisional; Region: PRK07236 316274007085 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274007086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274007087 Zn binding site [ion binding]; other site 316274007088 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 316274007089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274007090 Zn binding site [ion binding]; other site 316274007091 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 316274007092 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 316274007093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274007094 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 316274007095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274007096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274007097 active site 316274007098 phosphorylation site [posttranslational modification] 316274007099 intermolecular recognition site; other site 316274007100 dimerization interface [polypeptide binding]; other site 316274007101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274007102 DNA binding site [nucleotide binding] 316274007103 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 316274007104 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 316274007105 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316274007106 substrate binding pocket [chemical binding]; other site 316274007107 chain length determination region; other site 316274007108 substrate-Mg2+ binding site; other site 316274007109 catalytic residues [active] 316274007110 aspartate-rich region 1; other site 316274007111 active site lid residues [active] 316274007112 aspartate-rich region 2; other site 316274007113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274007114 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 316274007115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316274007116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274007117 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316274007118 active site residue [active] 316274007119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274007120 Coenzyme A binding pocket [chemical binding]; other site 316274007121 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 316274007122 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274007123 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 316274007124 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 316274007125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274007126 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 316274007127 substrate binding site [chemical binding]; other site 316274007128 ATP binding site [chemical binding]; other site 316274007129 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 316274007130 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 316274007131 homotetramer interface [polypeptide binding]; other site 316274007132 ligand binding site [chemical binding]; other site 316274007133 catalytic site [active] 316274007134 NAD binding site [chemical binding]; other site 316274007135 S-adenosylmethionine synthetase; Validated; Region: PRK05250 316274007136 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 316274007137 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 316274007138 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 316274007139 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316274007140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274007141 Coenzyme A binding pocket [chemical binding]; other site 316274007142 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 316274007143 ADP-ribose binding site [chemical binding]; other site 316274007144 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274007145 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 316274007146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274007147 dimerization interface [polypeptide binding]; other site 316274007148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274007149 dimer interface [polypeptide binding]; other site 316274007150 phosphorylation site [posttranslational modification] 316274007151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007152 ATP binding site [chemical binding]; other site 316274007153 G-X-G motif; other site 316274007154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274007155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274007156 active site 316274007157 phosphorylation site [posttranslational modification] 316274007158 intermolecular recognition site; other site 316274007159 dimerization interface [polypeptide binding]; other site 316274007160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274007161 DNA binding site [nucleotide binding] 316274007162 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 316274007163 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 316274007164 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 316274007165 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 316274007166 putative dimer interface [polypeptide binding]; other site 316274007167 putative anticodon binding site; other site 316274007168 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 316274007169 homodimer interface [polypeptide binding]; other site 316274007170 motif 1; other site 316274007171 motif 2; other site 316274007172 active site 316274007173 motif 3; other site 316274007174 short chain dehydrogenase; Provisional; Region: PRK06701 316274007175 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 316274007176 NAD binding site [chemical binding]; other site 316274007177 metal binding site [ion binding]; metal-binding site 316274007178 active site 316274007179 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 316274007180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274007181 active site 316274007182 phosphorylation site [posttranslational modification] 316274007183 intermolecular recognition site; other site 316274007184 dimerization interface [polypeptide binding]; other site 316274007185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316274007186 Walker A motif; other site 316274007187 ATP binding site [chemical binding]; other site 316274007188 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316274007189 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316274007190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007191 ATP binding site [chemical binding]; other site 316274007192 G-X-G motif; other site 316274007193 Domain of unknown function (DUF305); Region: DUF305; pfam03713 316274007194 Predicted transcriptional regulator [Transcription]; Region: COG2345 316274007195 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 316274007196 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274007197 dimer interface [polypeptide binding]; other site 316274007198 active site 316274007199 Cellulose binding domain; Region: CBM_2; pfam00553 316274007200 CHAT domain; Region: CHAT; pfam12770 316274007201 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274007202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007203 O-Antigen ligase; Region: Wzy_C; pfam04932 316274007204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544 316274007205 homodimer interface [polypeptide binding]; other site 316274007206 active site 316274007207 metal binding site [ion binding]; metal-binding site 316274007208 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274007209 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274007210 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 316274007211 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274007212 active site 316274007213 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 316274007214 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274007215 putative NTP binding site [chemical binding]; other site 316274007216 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274007217 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274007218 putative active site [active] 316274007219 putative nucleic acid binding site [nucleotide binding]; other site 316274007220 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274007221 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274007222 WYL domain; Region: WYL; pfam13280 316274007223 Predicted membrane protein [Function unknown]; Region: COG4325 316274007224 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 316274007225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274007226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274007227 TPR motif; other site 316274007228 binding surface 316274007229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274007230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274007231 binding surface 316274007232 TPR motif; other site 316274007233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274007234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274007235 metal binding site [ion binding]; metal-binding site 316274007236 active site 316274007237 I-site; other site 316274007238 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 316274007239 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 316274007240 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274007241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274007242 Walker A/P-loop; other site 316274007243 ATP binding site [chemical binding]; other site 316274007244 Q-loop/lid; other site 316274007245 ABC transporter signature motif; other site 316274007246 Walker B; other site 316274007247 D-loop; other site 316274007248 H-loop/switch region; other site 316274007249 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316274007250 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274007251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274007252 Walker A/P-loop; other site 316274007253 ATP binding site [chemical binding]; other site 316274007254 Q-loop/lid; other site 316274007255 ABC transporter signature motif; other site 316274007256 Walker B; other site 316274007257 D-loop; other site 316274007258 H-loop/switch region; other site 316274007259 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316274007260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274007261 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274007262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274007263 dimer interface [polypeptide binding]; other site 316274007264 conserved gate region; other site 316274007265 putative PBP binding loops; other site 316274007266 ABC-ATPase subunit interface; other site 316274007267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274007268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274007269 dimer interface [polypeptide binding]; other site 316274007270 conserved gate region; other site 316274007271 putative PBP binding loops; other site 316274007272 ABC-ATPase subunit interface; other site 316274007273 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 316274007274 substrate binding site [chemical binding]; other site 316274007275 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274007276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274007277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274007278 DNA binding site [nucleotide binding] 316274007279 domain linker motif; other site 316274007280 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274007281 putative dimerization interface [polypeptide binding]; other site 316274007282 putative ligand binding site [chemical binding]; other site 316274007283 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 316274007284 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 316274007285 conserved cys residue [active] 316274007286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274007287 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274007288 conserved cys residue [active] 316274007289 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 316274007290 beta-galactosidase; Region: BGL; TIGR03356 316274007291 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 316274007292 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274007293 minor groove reading motif; other site 316274007294 helix-hairpin-helix signature motif; other site 316274007295 substrate binding pocket [chemical binding]; other site 316274007296 active site 316274007297 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 316274007298 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007299 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007300 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007301 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007302 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007303 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007304 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274007305 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 316274007306 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 316274007307 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274007308 active sites [active] 316274007309 tetramer interface [polypeptide binding]; other site 316274007310 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274007311 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 316274007312 acyl-activating enzyme (AAE) consensus motif; other site 316274007313 putative AMP binding site [chemical binding]; other site 316274007314 putative active site [active] 316274007315 putative CoA binding site [chemical binding]; other site 316274007316 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274007317 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274007318 active site 316274007319 TDP-binding site; other site 316274007320 acceptor substrate-binding pocket; other site 316274007321 homodimer interface [polypeptide binding]; other site 316274007322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274007323 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 316274007324 Walker A/P-loop; other site 316274007325 ATP binding site [chemical binding]; other site 316274007326 Q-loop/lid; other site 316274007327 ABC transporter signature motif; other site 316274007328 Walker B; other site 316274007329 D-loop; other site 316274007330 H-loop/switch region; other site 316274007331 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 316274007332 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274007333 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274007334 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274007335 active site 316274007336 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274007337 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 316274007338 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274007339 KR domain; Region: KR; pfam08659 316274007340 putative NADP binding site [chemical binding]; other site 316274007341 active site 316274007342 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274007343 Condensation domain; Region: Condensation; pfam00668 316274007344 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274007345 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274007346 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274007347 acyl-activating enzyme (AAE) consensus motif; other site 316274007348 AMP binding site [chemical binding]; other site 316274007349 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274007350 Condensation domain; Region: Condensation; pfam00668 316274007351 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274007352 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274007353 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274007354 AMP-binding enzyme; Region: AMP-binding; pfam00501 316274007355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274007356 AMP binding site [chemical binding]; other site 316274007357 active site 316274007358 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 316274007359 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274007360 acyl-activating enzyme (AAE) consensus motif; other site 316274007361 putative AMP binding site [chemical binding]; other site 316274007362 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274007363 putative NADP binding site [chemical binding]; other site 316274007364 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274007365 active site 316274007366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274007367 Condensation domain; Region: Condensation; pfam00668 316274007368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274007369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274007370 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274007371 acyl-activating enzyme (AAE) consensus motif; other site 316274007372 AMP binding site [chemical binding]; other site 316274007373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274007374 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274007375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274007376 active site 316274007377 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274007378 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274007379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274007380 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274007381 Thioesterase domain; Region: Thioesterase; pfam00975 316274007382 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274007383 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274007384 homodimer interface [polypeptide binding]; other site 316274007385 active site 316274007386 TDP-binding site; other site 316274007387 acceptor substrate-binding pocket; other site 316274007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274007389 HAMP domain; Region: HAMP; pfam00672 316274007390 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007391 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 316274007392 beta-galactosidase; Region: BGL; TIGR03356 316274007393 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 316274007394 catalytic motif [active] 316274007395 Zn binding site [ion binding]; other site 316274007396 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 316274007397 RibD C-terminal domain; Region: RibD_C; cl17279 316274007398 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274007399 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274007400 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 316274007401 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 316274007402 active site 316274007403 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 316274007404 active site 316274007405 Ap6A binding site [chemical binding]; other site 316274007406 nudix motif; other site 316274007407 metal binding site [ion binding]; metal-binding site 316274007408 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274007409 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274007410 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 316274007411 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274007412 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274007413 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274007414 active site 316274007415 catalytic tetrad [active] 316274007416 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 316274007417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007419 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 316274007420 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274007421 active site 316274007422 catalytic site [active] 316274007423 WYL domain; Region: WYL; pfam13280 316274007424 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 316274007425 putative active site pocket [active] 316274007426 dimerization interface [polypeptide binding]; other site 316274007427 putative catalytic residue [active] 316274007428 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 316274007429 dimer interface [polypeptide binding]; other site 316274007430 substrate binding site [chemical binding]; other site 316274007431 ATP binding site [chemical binding]; other site 316274007432 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 316274007433 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316274007434 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316274007435 Walker A/P-loop; other site 316274007436 ATP binding site [chemical binding]; other site 316274007437 Q-loop/lid; other site 316274007438 ABC transporter signature motif; other site 316274007439 Walker B; other site 316274007440 D-loop; other site 316274007441 H-loop/switch region; other site 316274007442 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 316274007443 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316274007444 Walker A/P-loop; other site 316274007445 ATP binding site [chemical binding]; other site 316274007446 Q-loop/lid; other site 316274007447 ABC transporter signature motif; other site 316274007448 Walker B; other site 316274007449 D-loop; other site 316274007450 H-loop/switch region; other site 316274007451 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 316274007452 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 316274007453 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 316274007454 thiamine phosphate binding site [chemical binding]; other site 316274007455 active site 316274007456 pyrophosphate binding site [ion binding]; other site 316274007457 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 316274007458 substrate binding site [chemical binding]; other site 316274007459 multimerization interface [polypeptide binding]; other site 316274007460 ATP binding site [chemical binding]; other site 316274007461 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 316274007462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274007463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316274007464 Isochorismatase family; Region: Isochorismatase; pfam00857 316274007465 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316274007466 catalytic triad [active] 316274007467 conserved cis-peptide bond; other site 316274007468 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 316274007469 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274007470 urease subunit alpha; Reviewed; Region: ureC; PRK13207 316274007471 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 316274007472 subunit interactions [polypeptide binding]; other site 316274007473 active site 316274007474 flap region; other site 316274007475 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 316274007476 gamma-beta subunit interface [polypeptide binding]; other site 316274007477 alpha-beta subunit interface [polypeptide binding]; other site 316274007478 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 316274007479 alpha-gamma subunit interface [polypeptide binding]; other site 316274007480 beta-gamma subunit interface [polypeptide binding]; other site 316274007481 UreD urease accessory protein; Region: UreD; pfam01774 316274007482 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 316274007483 UreF; Region: UreF; pfam01730 316274007484 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274007485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007486 active site 316274007487 ATP binding site [chemical binding]; other site 316274007488 substrate binding site [chemical binding]; other site 316274007489 activation loop (A-loop); other site 316274007490 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 316274007491 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 316274007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274007493 Coenzyme A binding pocket [chemical binding]; other site 316274007494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274007495 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316274007496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274007497 NAD(P) binding site [chemical binding]; other site 316274007498 active site 316274007499 HEAT repeats; Region: HEAT_2; pfam13646 316274007500 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 316274007501 protein binding surface [polypeptide binding]; other site 316274007502 HEAT repeats; Region: HEAT_2; pfam13646 316274007503 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 316274007504 nucleotide binding site/active site [active] 316274007505 HIT family signature motif; other site 316274007506 catalytic residue [active] 316274007507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007508 Interdomain contacts; other site 316274007509 Cytokine receptor motif; other site 316274007510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007511 Interdomain contacts; other site 316274007512 Cytokine receptor motif; other site 316274007513 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007514 Interdomain contacts; other site 316274007515 Cytokine receptor motif; other site 316274007516 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007517 Interdomain contacts; other site 316274007518 Cytokine receptor motif; other site 316274007519 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007520 Interdomain contacts; other site 316274007521 Cytokine receptor motif; other site 316274007522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274007523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274007524 DNA binding site [nucleotide binding] 316274007525 domain linker motif; other site 316274007526 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 316274007527 putative dimerization interface [polypeptide binding]; other site 316274007528 putative ligand binding site [chemical binding]; other site 316274007529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274007530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274007531 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274007532 AAA ATPase domain; Region: AAA_16; pfam13191 316274007533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274007534 DNA binding residues [nucleotide binding] 316274007535 dimerization interface [polypeptide binding]; other site 316274007536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274007537 catalytic core [active] 316274007538 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 316274007539 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316274007540 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 316274007541 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274007542 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316274007543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274007544 dimer interface [polypeptide binding]; other site 316274007545 conserved gate region; other site 316274007546 putative PBP binding loops; other site 316274007547 ABC-ATPase subunit interface; other site 316274007548 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274007549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274007550 Walker A/P-loop; other site 316274007551 ATP binding site [chemical binding]; other site 316274007552 Q-loop/lid; other site 316274007553 ABC transporter signature motif; other site 316274007554 Walker B; other site 316274007555 D-loop; other site 316274007556 H-loop/switch region; other site 316274007557 TOBE domain; Region: TOBE_2; pfam08402 316274007558 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 316274007559 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 316274007560 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 316274007561 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 316274007562 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 316274007563 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 316274007564 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274007565 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274007566 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274007567 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274007568 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274007569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 316274007570 putative dimer interface [polypeptide binding]; other site 316274007571 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274007572 Uncharacterized conserved protein [Function unknown]; Region: COG1479 316274007573 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 316274007574 DinB superfamily; Region: DinB_2; pfam12867 316274007575 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 316274007576 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 316274007577 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 316274007578 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 316274007579 active site 316274007580 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 316274007581 Chitinase C; Region: ChiC; pfam06483 316274007582 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 316274007583 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316274007584 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274007585 Putative zinc-finger; Region: zf-HC2; pfam13490 316274007586 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274007587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274007589 DNA binding residues [nucleotide binding] 316274007590 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274007591 PAS fold; Region: PAS_4; pfam08448 316274007592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274007593 putative active site [active] 316274007594 heme pocket [chemical binding]; other site 316274007595 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316274007596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274007597 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 316274007598 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 316274007599 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 316274007600 hydroxyglutarate oxidase; Provisional; Region: PRK11728 316274007601 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 316274007602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 316274007603 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316274007604 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 316274007605 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 316274007606 inhibitor site; inhibition site 316274007607 active site 316274007608 dimer interface [polypeptide binding]; other site 316274007609 catalytic residue [active] 316274007610 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 316274007611 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 316274007612 dimer interface [polypeptide binding]; other site 316274007613 NADP binding site [chemical binding]; other site 316274007614 catalytic residues [active] 316274007615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274007616 Walker A motif; other site 316274007617 ATP binding site [chemical binding]; other site 316274007618 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 316274007619 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 316274007620 ATP binding site [chemical binding]; other site 316274007621 Walker A motif; other site 316274007622 hexamer interface [polypeptide binding]; other site 316274007623 Walker B motif; other site 316274007624 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 316274007625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274007626 Coenzyme A binding pocket [chemical binding]; other site 316274007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 316274007628 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 316274007629 catalytic nucleophile [active] 316274007630 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 316274007631 active site 316274007632 catalytic residues [active] 316274007633 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274007634 Interdomain contacts; other site 316274007635 Cytokine receptor motif; other site 316274007636 Cellulose binding domain; Region: CBM_2; pfam00553 316274007637 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274007638 sugar binding site [chemical binding]; other site 316274007639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274007640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274007641 DNA binding residues [nucleotide binding] 316274007642 dimerization interface [polypeptide binding]; other site 316274007643 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 316274007644 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 316274007645 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 316274007646 RuvA N terminal domain; Region: RuvA_N; pfam01330 316274007647 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274007648 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316274007649 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 316274007650 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 316274007651 inhibitor binding site; inhibition site 316274007652 active site 316274007653 Methyltransferase domain; Region: Methyltransf_12; pfam08242 316274007654 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 316274007655 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 316274007656 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 316274007657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007659 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274007660 Cytochrome P450; Region: p450; pfam00067 316274007661 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 316274007662 Flavodoxin; Region: Flavodoxin_1; pfam00258 316274007663 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 316274007664 FAD binding pocket [chemical binding]; other site 316274007665 FAD binding motif [chemical binding]; other site 316274007666 catalytic residues [active] 316274007667 NAD binding pocket [chemical binding]; other site 316274007668 phosphate binding motif [ion binding]; other site 316274007669 beta-alpha-beta structure motif; other site 316274007670 PAS fold; Region: PAS_4; pfam08448 316274007671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274007672 putative active site [active] 316274007673 heme pocket [chemical binding]; other site 316274007674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274007675 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274007676 putative active site [active] 316274007677 heme pocket [chemical binding]; other site 316274007678 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274007679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274007680 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274007681 putative active site [active] 316274007682 heme pocket [chemical binding]; other site 316274007683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274007684 putative active site [active] 316274007685 heme pocket [chemical binding]; other site 316274007686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274007687 dimer interface [polypeptide binding]; other site 316274007688 phosphorylation site [posttranslational modification] 316274007689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274007690 ATP binding site [chemical binding]; other site 316274007691 Mg2+ binding site [ion binding]; other site 316274007692 G-X-G motif; other site 316274007693 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274007694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274007695 active site 316274007696 phosphorylation site [posttranslational modification] 316274007697 intermolecular recognition site; other site 316274007698 dimerization interface [polypeptide binding]; other site 316274007699 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 316274007700 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 316274007701 NAD(P) binding site [chemical binding]; other site 316274007702 catalytic residues [active] 316274007703 Helix-turn-helix domain; Region: HTH_17; cl17695 316274007704 Predicted transcriptional regulators [Transcription]; Region: COG1695 316274007705 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 316274007706 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 316274007707 nudix motif; other site 316274007708 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 316274007709 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316274007710 trimerization site [polypeptide binding]; other site 316274007711 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 316274007712 active site 316274007713 PGAP1-like protein; Region: PGAP1; pfam07819 316274007714 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 316274007715 AAA ATPase domain; Region: AAA_16; pfam13191 316274007716 Predicted ATPase [General function prediction only]; Region: COG3903 316274007717 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274007718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274007719 binding surface 316274007720 TPR motif; other site 316274007721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274007722 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 316274007723 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 316274007724 Ligand Binding Site [chemical binding]; other site 316274007725 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 316274007726 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 316274007727 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 316274007728 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274007729 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 316274007730 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 316274007731 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 316274007732 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 316274007733 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 316274007734 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 316274007735 PLD-like domain; Region: PLDc_2; pfam13091 316274007736 putative homodimer interface [polypeptide binding]; other site 316274007737 putative active site [active] 316274007738 catalytic site [active] 316274007739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274007740 ATP binding site [chemical binding]; other site 316274007741 putative Mg++ binding site [ion binding]; other site 316274007742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274007743 nucleotide binding region [chemical binding]; other site 316274007744 ATP-binding site [chemical binding]; other site 316274007745 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 316274007746 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 316274007747 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 316274007748 active site 316274007749 nucleophile elbow; other site 316274007750 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 316274007751 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 316274007752 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 316274007753 substrate binding pocket [chemical binding]; other site 316274007754 dimer interface [polypeptide binding]; other site 316274007755 inhibitor binding site; inhibition site 316274007756 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316274007757 B12 binding site [chemical binding]; other site 316274007758 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 316274007759 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 316274007760 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 316274007761 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 316274007762 trimer interface [polypeptide binding]; other site 316274007763 active site 316274007764 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 316274007765 catalytic site [active] 316274007766 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 316274007767 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 316274007768 5S rRNA interface [nucleotide binding]; other site 316274007769 CTC domain interface [polypeptide binding]; other site 316274007770 L16 interface [polypeptide binding]; other site 316274007771 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 316274007772 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274007773 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274007774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274007775 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274007776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274007777 DNA binding residues [nucleotide binding] 316274007778 HerA helicase [Replication, recombination, and repair]; Region: COG0433 316274007779 Domain of unknown function DUF87; Region: DUF87; pfam01935 316274007780 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 316274007781 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274007782 Walker A/P-loop; other site 316274007783 ATP binding site [chemical binding]; other site 316274007784 Q-loop/lid; other site 316274007785 ABC transporter signature motif; other site 316274007786 Walker B; other site 316274007787 D-loop; other site 316274007788 H-loop/switch region; other site 316274007789 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274007790 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274007791 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 316274007792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007794 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 316274007795 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316274007796 catalytic site [active] 316274007797 TAP-like protein; Region: Abhydrolase_4; pfam08386 316274007798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274007799 S-adenosylmethionine binding site [chemical binding]; other site 316274007800 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 316274007801 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316274007802 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274007803 classical (c) SDRs; Region: SDR_c; cd05233 316274007804 NAD(P) binding site [chemical binding]; other site 316274007805 active site 316274007806 Threonine dehydrogenase; Region: TDH; cd05281 316274007807 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 316274007808 structural Zn binding site [ion binding]; other site 316274007809 catalytic Zn binding site [ion binding]; other site 316274007810 tetramer interface [polypeptide binding]; other site 316274007811 NADP binding site [chemical binding]; other site 316274007812 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 316274007813 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316274007814 active site 316274007815 substrate binding site [chemical binding]; other site 316274007816 metal binding site [ion binding]; metal-binding site 316274007817 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 316274007818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274007819 inhibitor-cofactor binding pocket; inhibition site 316274007820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274007821 catalytic residue [active] 316274007822 Double zinc ribbon; Region: DZR; pfam12773 316274007823 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274007824 Uncharacterized conserved protein [Function unknown]; Region: COG0327 316274007825 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 316274007826 Integral membrane protein TerC family; Region: TerC; cl10468 316274007827 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 316274007828 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 316274007829 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 316274007830 substrate binding site [chemical binding]; other site 316274007831 THF binding site; other site 316274007832 zinc-binding site [ion binding]; other site 316274007833 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 316274007834 dimer interface [polypeptide binding]; other site 316274007835 putative radical transfer pathway; other site 316274007836 diiron center [ion binding]; other site 316274007837 tyrosyl radical; other site 316274007838 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 316274007839 Class I ribonucleotide reductase; Region: RNR_I; cd01679 316274007840 active site 316274007841 dimer interface [polypeptide binding]; other site 316274007842 catalytic residues [active] 316274007843 effector binding site; other site 316274007844 R2 peptide binding site; other site 316274007845 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274007846 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274007847 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 316274007848 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274007849 active site 316274007850 ATP binding site [chemical binding]; other site 316274007851 substrate binding site [chemical binding]; other site 316274007852 activation loop (A-loop); other site 316274007853 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274007854 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 316274007855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007857 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007858 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 316274007859 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007860 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007861 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007862 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274007863 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274007864 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 316274007865 phosphopeptide binding site; other site 316274007866 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274007867 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274007868 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274007869 metal ion-dependent adhesion site (MIDAS); other site 316274007870 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274007871 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274007872 phosphopeptide binding site; other site 316274007873 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 316274007874 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 316274007875 tetramer interface [polypeptide binding]; other site 316274007876 TPP-binding site [chemical binding]; other site 316274007877 heterodimer interface [polypeptide binding]; other site 316274007878 phosphorylation loop region [posttranslational modification] 316274007879 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 316274007880 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 316274007881 alpha subunit interface [polypeptide binding]; other site 316274007882 TPP binding site [chemical binding]; other site 316274007883 heterodimer interface [polypeptide binding]; other site 316274007884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274007885 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 316274007886 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274007887 E3 interaction surface; other site 316274007888 lipoyl attachment site [posttranslational modification]; other site 316274007889 e3 binding domain; Region: E3_binding; pfam02817 316274007890 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316274007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274007892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274007893 putative substrate translocation pore; other site 316274007894 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274007895 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274007896 Ligand binding site; other site 316274007897 Ligand binding site; other site 316274007898 Ligand binding site; other site 316274007899 Putative Catalytic site; other site 316274007900 DXD motif; other site 316274007901 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274007902 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274007903 Probable Catalytic site; other site 316274007904 metal-binding site 316274007905 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316274007906 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 316274007907 NADP binding site [chemical binding]; other site 316274007908 active site 316274007909 putative substrate binding site [chemical binding]; other site 316274007910 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 316274007911 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274007912 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274007913 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274007914 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 316274007915 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 316274007916 domain interfaces; other site 316274007917 active site 316274007918 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 316274007919 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316274007920 active site 316274007921 homodimer interface [polypeptide binding]; other site 316274007922 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 316274007923 active site 316274007924 catalytic triad [active] 316274007925 oxyanion hole [active] 316274007926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316274007927 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316274007928 Walker A/P-loop; other site 316274007929 ATP binding site [chemical binding]; other site 316274007930 Q-loop/lid; other site 316274007931 ABC transporter signature motif; other site 316274007932 Walker B; other site 316274007933 D-loop; other site 316274007934 H-loop/switch region; other site 316274007935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316274007936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316274007937 FtsX-like permease family; Region: FtsX; pfam02687 316274007938 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 316274007939 active site 316274007940 metal binding site [ion binding]; metal-binding site 316274007941 homotetramer interface [polypeptide binding]; other site 316274007942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274007943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274007944 active site 316274007945 catalytic tetrad [active] 316274007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274007948 Y-family of DNA polymerases; Region: PolY; cl12025 316274007949 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316274007950 catalytic triad [active] 316274007951 short chain dehydrogenase; Provisional; Region: PRK07035 316274007952 classical (c) SDRs; Region: SDR_c; cd05233 316274007953 NAD(P) binding site [chemical binding]; other site 316274007954 active site 316274007955 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 316274007956 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316274007957 active site 316274007958 NTP binding site [chemical binding]; other site 316274007959 metal binding triad [ion binding]; metal-binding site 316274007960 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316274007961 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 316274007962 active site 316274007963 catalytic triad [active] 316274007964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 316274007965 catalytic residues [active] 316274007966 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274007967 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274007968 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274007969 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 316274007970 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 316274007971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274007972 active site 316274007973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274007974 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 316274007975 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316274007976 Uncharacterized conserved protein [Function unknown]; Region: COG3339 316274007977 TPR repeat; Region: TPR_11; pfam13414 316274007978 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316274007979 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 316274007980 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 316274007981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274007982 binding surface 316274007983 TPR motif; other site 316274007984 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 316274007985 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274007986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274007987 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316274007988 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316274007989 carboxyltransferase (CT) interaction site; other site 316274007990 biotinylation site [posttranslational modification]; other site 316274007991 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 316274007992 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274007993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274007994 motif II; other site 316274007995 Phosphotransferase enzyme family; Region: APH; pfam01636 316274007996 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274007997 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 316274007998 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274007999 active site 316274008000 NTP binding site [chemical binding]; other site 316274008001 nucleic acid binding site [nucleotide binding]; other site 316274008002 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 316274008003 ATP phosphoribosyltransferase; Region: HisG; cl15266 316274008004 HisG, C-terminal domain; Region: HisG_C; cl06867 316274008005 CopC domain; Region: CopC; pfam04234 316274008006 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 316274008007 CopC domain; Region: CopC; pfam04234 316274008008 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 316274008009 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316274008010 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 316274008011 AAA domain; Region: AAA_23; pfam13476 316274008012 Walker A/P-loop; other site 316274008013 ATP binding site [chemical binding]; other site 316274008014 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 316274008015 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 316274008016 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 316274008017 ABC transporter signature motif; other site 316274008018 Walker B; other site 316274008019 D-loop; other site 316274008020 H-loop/switch region; other site 316274008021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274008022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274008023 Coenzyme A binding pocket [chemical binding]; other site 316274008024 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 316274008025 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 316274008026 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274008027 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316274008028 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316274008029 cofactor binding site; other site 316274008030 DNA binding site [nucleotide binding] 316274008031 substrate interaction site [chemical binding]; other site 316274008032 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 316274008033 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 316274008034 Cellulose binding domain; Region: CBM_2; pfam00553 316274008035 Chitin binding domain; Region: Chitin_bind_3; pfam03067 316274008036 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274008037 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316274008038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274008039 salt bridge; other site 316274008040 non-specific DNA binding site [nucleotide binding]; other site 316274008041 sequence-specific DNA binding site [nucleotide binding]; other site 316274008042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274008043 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 316274008044 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316274008045 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316274008046 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 316274008047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008048 NAD(P) binding site [chemical binding]; other site 316274008049 active site 316274008050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274008051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274008052 ligand binding site [chemical binding]; other site 316274008053 flexible hinge region; other site 316274008054 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 316274008055 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 316274008056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274008057 ATP binding site [chemical binding]; other site 316274008058 putative Mg++ binding site [ion binding]; other site 316274008059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274008060 nucleotide binding region [chemical binding]; other site 316274008061 ATP-binding site [chemical binding]; other site 316274008062 TRCF domain; Region: TRCF; pfam03461 316274008063 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274008064 peptide binding site [polypeptide binding]; other site 316274008065 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274008066 dimer interface [polypeptide binding]; other site 316274008067 phosphodiesterase YaeI; Provisional; Region: PRK11340 316274008068 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274008069 putative active site [active] 316274008070 putative metal binding site [ion binding]; other site 316274008071 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 316274008072 Yqey-like protein; Region: YqeY; pfam09424 316274008073 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 316274008074 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 316274008075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274008076 Zn2+ binding site [ion binding]; other site 316274008077 Mg2+ binding site [ion binding]; other site 316274008078 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 316274008079 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 316274008080 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 316274008081 active site 316274008082 Zn binding site [ion binding]; other site 316274008083 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274008084 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274008085 VanW like protein; Region: VanW; pfam04294 316274008086 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 316274008087 active site 316274008088 thymidine kinase; Provisional; Region: PRK04296 316274008089 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 316274008090 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 316274008091 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 316274008092 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 316274008093 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274008094 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 316274008095 active site 316274008096 substrate binding site [chemical binding]; other site 316274008097 Mg2+ binding site [ion binding]; other site 316274008098 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 316274008099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008100 Walker A/P-loop; other site 316274008101 ATP binding site [chemical binding]; other site 316274008102 Q-loop/lid; other site 316274008103 ABC transporter signature motif; other site 316274008104 Walker B; other site 316274008105 D-loop; other site 316274008106 H-loop/switch region; other site 316274008107 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 316274008108 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274008109 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274008110 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 316274008111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274008112 Thiamine pyrophosphokinase; Region: TPK; cd07995 316274008113 active site 316274008114 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 316274008115 dimerization interface [polypeptide binding]; other site 316274008116 thiamine binding site [chemical binding]; other site 316274008117 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316274008118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274008119 motif II; other site 316274008120 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274008121 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274008122 Probable Catalytic site; other site 316274008123 metal-binding site 316274008124 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274008125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008126 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274008127 putative catalytic site [active] 316274008128 putative metal binding site [ion binding]; other site 316274008129 putative phosphate binding site [ion binding]; other site 316274008130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274008131 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274008132 TM-ABC transporter signature motif; other site 316274008133 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274008134 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 316274008135 TM-ABC transporter signature motif; other site 316274008136 polyphosphate kinase; Provisional; Region: PRK05443 316274008137 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 316274008138 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 316274008139 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 316274008140 putative domain interface [polypeptide binding]; other site 316274008141 putative active site [active] 316274008142 catalytic site [active] 316274008143 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 316274008144 putative domain interface [polypeptide binding]; other site 316274008145 putative active site [active] 316274008146 catalytic site [active] 316274008147 Protein of unknown function (DUF983); Region: DUF983; cl02211 316274008148 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008149 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 316274008150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008151 ATP binding site [chemical binding]; other site 316274008152 Mg2+ binding site [ion binding]; other site 316274008153 G-X-G motif; other site 316274008154 Predicted flavoprotein [General function prediction only]; Region: COG0431 316274008155 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 316274008156 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274008157 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274008158 Zn binding site [ion binding]; other site 316274008159 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 316274008160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274008161 Zn binding site [ion binding]; other site 316274008162 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 316274008163 putative hydrolase; Provisional; Region: PRK11460 316274008164 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 316274008165 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316274008166 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316274008167 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274008168 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274008169 Probable Catalytic site; other site 316274008170 metal-binding site 316274008171 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 316274008172 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 316274008173 Timeless protein; Region: TIMELESS; pfam04821 316274008174 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 316274008175 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 316274008176 VanZ like family; Region: VanZ; pfam04892 316274008177 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316274008178 active site residue [active] 316274008179 Domain of unknown function (DUF309); Region: DUF309; pfam03745 316274008180 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316274008181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274008182 active site 316274008183 phosphorylation site [posttranslational modification] 316274008184 intermolecular recognition site; other site 316274008185 dimerization interface [polypeptide binding]; other site 316274008186 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274008187 Zn2+ binding site [ion binding]; other site 316274008188 Mg2+ binding site [ion binding]; other site 316274008189 Trm112p-like protein; Region: Trm112p; pfam03966 316274008190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274008191 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274008192 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 316274008193 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274008194 DNA binding residues [nucleotide binding] 316274008195 B12 binding domain; Region: B12-binding_2; pfam02607 316274008196 B12 binding domain; Region: B12-binding; pfam02310 316274008197 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 316274008198 active site lid residues [active] 316274008199 substrate binding pocket [chemical binding]; other site 316274008200 catalytic residues [active] 316274008201 substrate-Mg2+ binding site; other site 316274008202 aspartate-rich region 1; other site 316274008203 aspartate-rich region 2; other site 316274008204 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316274008205 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 316274008206 putative NAD(P) binding site [chemical binding]; other site 316274008207 active site 316274008208 calcium/proton exchanger (cax); Region: cax; TIGR00378 316274008209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 316274008210 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 316274008211 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 316274008212 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 316274008213 Recombination protein O N terminal; Region: RecO_N; pfam11967 316274008214 Recombination protein O C terminal; Region: RecO_C; pfam02565 316274008215 Bacterial PH domain; Region: DUF304; pfam03703 316274008216 Short C-terminal domain; Region: SHOCT; pfam09851 316274008217 purine nucleoside phosphorylase; Provisional; Region: PRK08202 316274008218 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274008219 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316274008220 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274008221 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274008222 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274008223 ligand binding site [chemical binding]; other site 316274008224 flexible hinge region; other site 316274008225 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 316274008226 nucleotide binding site/active site [active] 316274008227 HIT family signature motif; other site 316274008228 catalytic residue [active] 316274008229 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 316274008230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008231 Walker A/P-loop; other site 316274008232 ATP binding site [chemical binding]; other site 316274008233 Q-loop/lid; other site 316274008234 ABC transporter signature motif; other site 316274008235 Walker B; other site 316274008236 D-loop; other site 316274008237 CcmB protein; Region: CcmB; cl17444 316274008238 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316274008239 CcmE; Region: CcmE; cl00994 316274008240 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 316274008241 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 316274008242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274008243 TPR motif; other site 316274008244 binding surface 316274008245 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 316274008246 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274008247 catalytic residues [active] 316274008248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274008249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274008250 active site 316274008251 phosphorylation site [posttranslational modification] 316274008252 intermolecular recognition site; other site 316274008253 dimerization interface [polypeptide binding]; other site 316274008254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274008255 DNA binding site [nucleotide binding] 316274008256 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 316274008257 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274008258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008259 Walker A/P-loop; other site 316274008260 ATP binding site [chemical binding]; other site 316274008261 Q-loop/lid; other site 316274008262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274008263 ABC transporter signature motif; other site 316274008264 Walker B; other site 316274008265 D-loop; other site 316274008266 ABC transporter; Region: ABC_tran_2; pfam12848 316274008267 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274008268 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 316274008269 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 316274008270 CoA-binding site [chemical binding]; other site 316274008271 ATP-binding [chemical binding]; other site 316274008272 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008273 GAF domain; Region: GAF; pfam01590 316274008274 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274008275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274008276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274008277 Histidine kinase; Region: HisKA_3; pfam07730 316274008278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008279 ATP binding site [chemical binding]; other site 316274008280 Mg2+ binding site [ion binding]; other site 316274008281 G-X-G motif; other site 316274008282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008283 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008284 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 316274008285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 316274008286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274008287 putative DNA binding site [nucleotide binding]; other site 316274008288 putative Zn2+ binding site [ion binding]; other site 316274008289 AsnC family; Region: AsnC_trans_reg; pfam01037 316274008290 VanW like protein; Region: VanW; pfam04294 316274008291 GAF domain; Region: GAF_2; pfam13185 316274008292 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274008293 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008294 GAF domain; Region: GAF; cl17456 316274008295 GAF domain; Region: GAF_2; pfam13185 316274008296 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008297 Uncharacterized conserved protein [Function unknown]; Region: COG3603 316274008298 Family description; Region: ACT_7; pfam13840 316274008299 ABC transporter G family member; Provisional; Region: PLN03140 316274008300 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 316274008301 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 316274008302 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 316274008303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 316274008304 metal binding site [ion binding]; metal-binding site 316274008305 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 316274008306 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 316274008307 purine monophosphate binding site [chemical binding]; other site 316274008308 dimer interface [polypeptide binding]; other site 316274008309 putative catalytic residues [active] 316274008310 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 316274008311 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 316274008312 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 316274008313 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274008314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274008315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008316 Walker A/P-loop; other site 316274008317 ATP binding site [chemical binding]; other site 316274008318 Q-loop/lid; other site 316274008319 ABC transporter signature motif; other site 316274008320 Walker B; other site 316274008321 D-loop; other site 316274008322 H-loop/switch region; other site 316274008323 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 316274008324 Glyco_18 domain; Region: Glyco_18; smart00636 316274008325 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 316274008326 active site 316274008327 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274008328 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316274008329 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 316274008330 active site 316274008331 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274008332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274008333 non-specific DNA binding site [nucleotide binding]; other site 316274008334 salt bridge; other site 316274008335 sequence-specific DNA binding site [nucleotide binding]; other site 316274008336 Restriction endonuclease BamHI; Region: BamHI; pfam02923 316274008337 Restriction endonuclease BamHI; Region: BamHI; pfam02923 316274008338 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274008339 DNA methylase; Region: N6_N4_Mtase; pfam01555 316274008340 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316274008341 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 316274008342 Walker A/P-loop; other site 316274008343 ATP binding site [chemical binding]; other site 316274008344 Q-loop/lid; other site 316274008345 ABC transporter signature motif; other site 316274008346 Walker B; other site 316274008347 D-loop; other site 316274008348 H-loop/switch region; other site 316274008349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274008350 dimer interface [polypeptide binding]; other site 316274008351 conserved gate region; other site 316274008352 putative PBP binding loops; other site 316274008353 ABC-ATPase subunit interface; other site 316274008354 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316274008355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316274008356 substrate binding pocket [chemical binding]; other site 316274008357 membrane-bound complex binding site; other site 316274008358 hinge residues; other site 316274008359 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316274008360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008361 putative substrate translocation pore; other site 316274008362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008363 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 316274008364 Predicted transcriptional regulators [Transcription]; Region: COG1378 316274008365 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 316274008366 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 316274008367 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 316274008368 dimer interface [polypeptide binding]; other site 316274008369 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 316274008370 active site 316274008371 Fe binding site [ion binding]; other site 316274008372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274008373 DNA binding residues [nucleotide binding] 316274008374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274008375 dimerization interface [polypeptide binding]; other site 316274008376 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 316274008377 active site 316274008378 homodimer interface [polypeptide binding]; other site 316274008379 SAM binding site [chemical binding]; other site 316274008380 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274008381 Predicted ATPase [General function prediction only]; Region: COG3903 316274008382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274008383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274008384 binding surface 316274008385 TPR motif; other site 316274008386 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274008387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274008388 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 316274008389 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 316274008390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274008391 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274008392 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 316274008393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274008394 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 316274008395 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274008396 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274008397 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 316274008398 putative metal binding site [ion binding]; other site 316274008399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274008400 E3 interaction surface; other site 316274008401 lipoyl attachment site [posttranslational modification]; other site 316274008402 e3 binding domain; Region: E3_binding; pfam02817 316274008403 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316274008404 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274008405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274008406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274008407 DNA binding residues [nucleotide binding] 316274008408 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 316274008409 SnoaL-like domain; Region: SnoaL_2; pfam12680 316274008410 classical (c) SDRs; Region: SDR_c; cd05233 316274008411 NAD(P) binding site [chemical binding]; other site 316274008412 active site 316274008413 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 316274008414 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 316274008415 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274008416 Phosphotransferase enzyme family; Region: APH; pfam01636 316274008417 active site 316274008418 substrate binding site [chemical binding]; other site 316274008419 ATP binding site [chemical binding]; other site 316274008420 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 316274008421 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 316274008422 active site 316274008423 HIGH motif; other site 316274008424 KMSKS motif; other site 316274008425 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 316274008426 tRNA binding surface [nucleotide binding]; other site 316274008427 anticodon binding site; other site 316274008428 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 316274008429 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316274008430 Walker A/P-loop; other site 316274008431 ATP binding site [chemical binding]; other site 316274008432 Q-loop/lid; other site 316274008433 ABC transporter signature motif; other site 316274008434 Walker B; other site 316274008435 D-loop; other site 316274008436 H-loop/switch region; other site 316274008437 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316274008438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274008439 dimer interface [polypeptide binding]; other site 316274008440 conserved gate region; other site 316274008441 putative PBP binding loops; other site 316274008442 ABC-ATPase subunit interface; other site 316274008443 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 316274008444 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 316274008445 active site 316274008446 dimer interface [polypeptide binding]; other site 316274008447 non-prolyl cis peptide bond; other site 316274008448 insertion regions; other site 316274008449 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316274008450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316274008451 substrate binding pocket [chemical binding]; other site 316274008452 membrane-bound complex binding site; other site 316274008453 hinge residues; other site 316274008454 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 316274008455 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 316274008456 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 316274008457 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 316274008458 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 316274008459 hypothetical protein; Provisional; Region: PRK07233 316274008460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274008461 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 316274008462 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 316274008463 peptide chain release factor 1; Validated; Region: prfA; PRK00591 316274008464 This domain is found in peptide chain release factors; Region: PCRF; smart00937 316274008465 RF-1 domain; Region: RF-1; pfam00472 316274008466 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 316274008467 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 316274008468 active site 316274008469 purine riboside binding site [chemical binding]; other site 316274008470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274008471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 316274008472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274008473 dimer interface [polypeptide binding]; other site 316274008474 phosphorylation site [posttranslational modification] 316274008475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008476 ATP binding site [chemical binding]; other site 316274008477 Mg2+ binding site [ion binding]; other site 316274008478 G-X-G motif; other site 316274008479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274008480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274008481 active site 316274008482 phosphorylation site [posttranslational modification] 316274008483 intermolecular recognition site; other site 316274008484 dimerization interface [polypeptide binding]; other site 316274008485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274008486 DNA binding site [nucleotide binding] 316274008487 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274008488 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316274008489 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274008490 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316274008491 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 316274008492 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 316274008493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274008494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008495 homodimer interface [polypeptide binding]; other site 316274008496 catalytic residue [active] 316274008497 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008498 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274008499 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274008500 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274008501 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316274008502 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316274008503 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316274008504 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 316274008505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274008506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274008507 catalytic residue [active] 316274008508 Predicted transcriptional regulators [Transcription]; Region: COG1695 316274008509 Transcriptional regulator PadR-like family; Region: PadR; cl17335 316274008510 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 316274008511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274008512 Membrane bound O-acyl transferase family; Region: MBOAT_2; pfam13813 316274008513 Kelch motif; Region: Kelch_1; pfam01344 316274008514 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 316274008515 Kelch motif; Region: Kelch_1; pfam01344 316274008516 Kelch motif; Region: Kelch_1; pfam01344 316274008517 Kelch motif; Region: Kelch_2; pfam07646 316274008518 Galactose oxidase, central domain; Region: Kelch_3; cl02701 316274008519 Kelch motif; Region: Kelch_1; pfam01344 316274008520 Kelch motif; Region: Kelch_6; pfam13964 316274008521 Kelch domain; Region: Kelch; smart00612 316274008522 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 316274008523 active site 316274008524 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 316274008525 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274008526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274008527 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 316274008528 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274008529 sugar binding site [chemical binding]; other site 316274008530 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274008531 sugar binding site [chemical binding]; other site 316274008532 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 316274008533 sugar binding site [chemical binding]; other site 316274008534 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 316274008535 active site 316274008536 catalytic residues [active] 316274008537 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 316274008538 Cellulose binding domain; Region: CBM_2; pfam00553 316274008539 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 316274008540 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 316274008541 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 316274008542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274008543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274008544 DNA binding residues [nucleotide binding] 316274008545 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 316274008546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 316274008547 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 316274008548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274008549 putative substrate translocation pore; other site 316274008550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 316274008551 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 316274008552 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 316274008553 trehalose synthase; Region: treS_nterm; TIGR02456 316274008554 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 316274008555 active site 316274008556 catalytic site [active] 316274008557 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 316274008558 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 316274008559 active site 316274008560 homotetramer interface [polypeptide binding]; other site 316274008561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 316274008562 Trehalase; Region: Trehalase; cl17346 316274008563 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 316274008564 hypothetical protein; Provisional; Region: PRK06446 316274008565 metal binding site [ion binding]; metal-binding site 316274008566 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 316274008567 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 316274008568 active site 316274008569 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 316274008570 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 316274008571 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 316274008572 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 316274008573 active site 316274008574 Response regulator receiver domain; Region: Response_reg; pfam00072 316274008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274008576 active site 316274008577 phosphorylation site [posttranslational modification] 316274008578 intermolecular recognition site; other site 316274008579 dimerization interface [polypeptide binding]; other site 316274008580 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274008581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274008582 ABC-ATPase subunit interface; other site 316274008583 dimer interface [polypeptide binding]; other site 316274008584 putative PBP binding regions; other site 316274008585 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274008586 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316274008587 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274008588 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274008589 intersubunit interface [polypeptide binding]; other site 316274008590 phosphopentomutase; Provisional; Region: PRK05362 316274008591 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 316274008592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274008593 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274008594 active site 316274008595 catalytic tetrad [active] 316274008596 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 316274008597 active site 316274008598 catalytic residues [active] 316274008599 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 316274008600 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 316274008601 PA/protease or protease-like domain interface [polypeptide binding]; other site 316274008602 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 316274008603 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316274008604 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 316274008605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 316274008606 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 316274008607 active site 316274008608 dimer interface [polypeptide binding]; other site 316274008609 motif 1; other site 316274008610 motif 2; other site 316274008611 motif 3; other site 316274008612 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 316274008613 anticodon binding site; other site 316274008614 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274008615 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274008616 catalytic site [active] 316274008617 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 316274008618 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316274008619 HIGH motif; other site 316274008620 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316274008621 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316274008622 active site 316274008623 KMSKS motif; other site 316274008624 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 316274008625 tRNA binding surface [nucleotide binding]; other site 316274008626 anticodon binding site; other site 316274008627 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 316274008628 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274008629 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 316274008630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274008631 FemAB family; Region: FemAB; pfam02388 316274008632 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 316274008633 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 316274008634 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 316274008635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274008636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008637 ATP binding site [chemical binding]; other site 316274008638 Mg2+ binding site [ion binding]; other site 316274008639 G-X-G motif; other site 316274008640 sulfite oxidase; Provisional; Region: PLN00177 316274008641 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 316274008642 Moco binding site; other site 316274008643 metal coordination site [ion binding]; other site 316274008644 dimerization interface [polypeptide binding]; other site 316274008645 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 316274008646 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274008647 AMMECR1; Region: AMMECR1; cl00911 316274008648 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 316274008649 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 316274008650 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 316274008651 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 316274008652 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316274008653 glycine cleavage system protein H; Provisional; Region: PRK13380 316274008654 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 316274008655 lipoyl attachment site [posttranslational modification]; other site 316274008656 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 316274008657 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 316274008658 tetramer interface [polypeptide binding]; other site 316274008659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008660 catalytic residue [active] 316274008661 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 316274008662 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 316274008663 tetramer interface [polypeptide binding]; other site 316274008664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008665 catalytic residue [active] 316274008666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274008668 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274008669 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274008670 HTH domain; Region: HTH_11; pfam08279 316274008671 WYL domain; Region: WYL; pfam13280 316274008672 Beta-lactamase; Region: Beta-lactamase; pfam00144 316274008673 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 316274008674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274008675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008676 Walker A/P-loop; other site 316274008677 ATP binding site [chemical binding]; other site 316274008678 Q-loop/lid; other site 316274008679 ABC transporter signature motif; other site 316274008680 Walker B; other site 316274008681 D-loop; other site 316274008682 H-loop/switch region; other site 316274008683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274008684 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316274008685 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274008686 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274008687 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274008688 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 316274008689 NADP binding site [chemical binding]; other site 316274008690 dimer interface [polypeptide binding]; other site 316274008691 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274008692 MarR family; Region: MarR_2; pfam12802 316274008693 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512 316274008694 active site 316274008695 dimer interface [polypeptide binding]; other site 316274008696 catalytic nucleophile [active] 316274008697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274008698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008699 NAD(P) binding site [chemical binding]; other site 316274008700 active site 316274008701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274008702 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 316274008703 ligand binding site [chemical binding]; other site 316274008704 flexible hinge region; other site 316274008705 putative switch regulator; other site 316274008706 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 316274008707 non-specific DNA interactions [nucleotide binding]; other site 316274008708 DNA binding site [nucleotide binding] 316274008709 sequence specific DNA binding site [nucleotide binding]; other site 316274008710 putative cAMP binding site [chemical binding]; other site 316274008711 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274008712 putative active site [active] 316274008713 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 316274008714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274008715 active site 316274008716 metal binding site [ion binding]; metal-binding site 316274008717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274008718 active site 316274008719 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274008720 active site 316274008721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274008722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274008723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274008724 cytochrome P450 83B1; Provisional; Region: PLN03234 316274008725 Cytochrome P450; Region: p450; pfam00067 316274008726 Resistant to P. syringae 6; Provisional; Region: PLN03210 316274008727 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274008728 MarR family; Region: MarR; pfam01047 316274008729 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 316274008730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008731 NAD(P) binding site [chemical binding]; other site 316274008732 active site 316274008733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316274008734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274008735 dimer interface [polypeptide binding]; other site 316274008736 conserved gate region; other site 316274008737 putative PBP binding loops; other site 316274008738 ABC-ATPase subunit interface; other site 316274008739 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 316274008740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316274008741 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316274008742 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274008743 RNA binding surface [nucleotide binding]; other site 316274008744 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316274008745 active site 316274008746 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 316274008747 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316274008748 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274008749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274008750 active site 316274008751 metal binding site [ion binding]; metal-binding site 316274008752 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274008753 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274008754 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274008755 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274008756 Interdomain contacts; other site 316274008757 Cytokine receptor motif; other site 316274008758 E3 Ubiquitin ligase; Region: GIDE; pfam12483 316274008759 Peptidase family M48; Region: Peptidase_M48; cl12018 316274008760 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 316274008761 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 316274008762 active site 316274008763 Zn binding site [ion binding]; other site 316274008764 4-alpha-glucanotransferase; Provisional; Region: PRK14508 316274008765 NHL repeat; Region: NHL; pfam01436 316274008766 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274008767 NHL repeat; Region: NHL; pfam01436 316274008768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274008769 dimerization interface [polypeptide binding]; other site 316274008770 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274008771 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274008772 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 316274008773 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 316274008774 Predicted esterase [General function prediction only]; Region: COG0400 316274008775 putative hydrolase; Provisional; Region: PRK11460 316274008776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274008777 pteridine reductase; Provisional; Region: PRK09135 316274008778 NAD(P) binding site [chemical binding]; other site 316274008779 active site 316274008780 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274008782 S-adenosylmethionine binding site [chemical binding]; other site 316274008783 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 316274008784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274008785 binding surface 316274008786 TPR motif; other site 316274008787 TPR repeat; Region: TPR_11; pfam13414 316274008788 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 316274008789 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 316274008790 putative active site [active] 316274008791 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 316274008792 putative active site [active] 316274008793 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 316274008794 Active_site [active] 316274008795 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316274008796 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 316274008797 putative [Fe4-S4] binding site [ion binding]; other site 316274008798 putative molybdopterin cofactor binding site [chemical binding]; other site 316274008799 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 316274008800 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 316274008801 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 316274008802 HflX GTPase family; Region: HflX; cd01878 316274008803 G1 box; other site 316274008804 GTP/Mg2+ binding site [chemical binding]; other site 316274008805 Switch I region; other site 316274008806 G2 box; other site 316274008807 G3 box; other site 316274008808 Switch II region; other site 316274008809 G4 box; other site 316274008810 G5 box; other site 316274008811 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274008812 amidase catalytic site [active] 316274008813 Zn binding residues [ion binding]; other site 316274008814 substrate binding site [chemical binding]; other site 316274008815 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274008816 catalytic core [active] 316274008817 Cache domain; Region: Cache_1; pfam02743 316274008818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274008819 dimerization interface [polypeptide binding]; other site 316274008820 bZIP Maf transcription factor; Region: bZIP_Maf; pfam03131 316274008821 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008822 NMT1/THI5 like; Region: NMT1; pfam09084 316274008823 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 316274008824 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 316274008825 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 316274008826 NADP binding site [chemical binding]; other site 316274008827 active site 316274008828 steroid binding site; other site 316274008829 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 316274008830 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008831 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 316274008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274008833 ATP binding site [chemical binding]; other site 316274008834 Mg2+ binding site [ion binding]; other site 316274008835 G-X-G motif; other site 316274008836 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274008837 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274008838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316274008839 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 316274008840 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 316274008841 putative active site; other site 316274008842 catalytic residue [active] 316274008843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274008844 active site 316274008845 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274008846 nudix motif; other site 316274008847 putative acetyltransferase; Provisional; Region: PRK03624 316274008848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274008849 Coenzyme A binding pocket [chemical binding]; other site 316274008850 Predicted acetyltransferase [General function prediction only]; Region: COG5628 316274008851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 316274008852 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 316274008853 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 316274008854 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 316274008855 putative NAD(P) binding site [chemical binding]; other site 316274008856 putative substrate binding site [chemical binding]; other site 316274008857 catalytic Zn binding site [ion binding]; other site 316274008858 structural Zn binding site [ion binding]; other site 316274008859 dimer interface [polypeptide binding]; other site 316274008860 PAS fold; Region: PAS_4; pfam08448 316274008861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274008862 putative active site [active] 316274008863 heme pocket [chemical binding]; other site 316274008864 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274008865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274008866 putative active site [active] 316274008867 heme pocket [chemical binding]; other site 316274008868 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008869 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274008870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274008871 Serine hydrolase; Region: Ser_hydrolase; cl17834 316274008872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274008873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274008874 WHG domain; Region: WHG; pfam13305 316274008875 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 316274008876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274008877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274008878 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274008879 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 316274008880 PLD-like domain; Region: PLDc_2; pfam13091 316274008881 putative active site [active] 316274008882 catalytic site [active] 316274008883 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 316274008884 PLD-like domain; Region: PLDc_2; pfam13091 316274008885 putative active site [active] 316274008886 catalytic site [active] 316274008887 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 316274008888 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274008889 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274008890 active site 316274008891 ATP binding site [chemical binding]; other site 316274008892 substrate binding site [chemical binding]; other site 316274008893 activation loop (A-loop); other site 316274008894 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 316274008895 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 316274008896 RNase_H superfamily; Region: RNase_H_2; pfam13482 316274008897 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 316274008898 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 316274008899 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 316274008900 Rrf2 family protein; Region: rrf2_super; TIGR00738 316274008901 Transcriptional regulator; Region: Rrf2; pfam02082 316274008902 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 316274008903 selenocysteine synthase; Provisional; Region: PRK04311 316274008904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274008905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274008906 catalytic residue [active] 316274008907 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274008908 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274008909 active site 316274008910 ATP binding site [chemical binding]; other site 316274008911 substrate binding site [chemical binding]; other site 316274008912 activation loop (A-loop); other site 316274008913 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274008914 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274008915 phosphopeptide binding site; other site 316274008916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274008917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274008918 DNA binding site [nucleotide binding] 316274008919 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 316274008920 GTP/Mg2+ binding site [chemical binding]; other site 316274008921 G5 box; other site 316274008922 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 316274008923 Dynamin family; Region: Dynamin_N; pfam00350 316274008924 G1 box; other site 316274008925 G1 box; other site 316274008926 GTP/Mg2+ binding site [chemical binding]; other site 316274008927 G2 box; other site 316274008928 Switch I region; other site 316274008929 G3 box; other site 316274008930 Switch II region; other site 316274008931 G4 box; other site 316274008932 G5 box; other site 316274008933 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 316274008934 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274008935 active site 316274008936 catalytic site [active] 316274008937 Protein of unknown function (DUF952); Region: DUF952; cl01393 316274008938 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 316274008939 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274008940 active site 316274008941 HIGH motif; other site 316274008942 nucleotide binding site [chemical binding]; other site 316274008943 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 316274008944 active site 316274008945 KMSKS motif; other site 316274008946 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 316274008947 tRNA binding surface [nucleotide binding]; other site 316274008948 anticodon binding site; other site 316274008949 Dehydroquinase class II; Region: DHquinase_II; pfam01220 316274008950 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 316274008951 trimer interface [polypeptide binding]; other site 316274008952 active site 316274008953 dimer interface [polypeptide binding]; other site 316274008954 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316274008955 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316274008956 CAAX protease self-immunity; Region: Abi; pfam02517 316274008957 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274008958 Putative Ig domain; Region: He_PIG; pfam05345 316274008959 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 316274008960 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 316274008961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008962 Walker A/P-loop; other site 316274008963 ATP binding site [chemical binding]; other site 316274008964 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 316274008965 active site 316274008966 metal binding site [ion binding]; metal-binding site 316274008967 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 316274008968 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 316274008969 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 316274008970 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274008971 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274008972 substrate binding pocket [chemical binding]; other site 316274008973 substrate-Mg2+ binding site; other site 316274008974 aspartate-rich region 1; other site 316274008975 aspartate-rich region 2; other site 316274008976 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274008977 substrate binding pocket [chemical binding]; other site 316274008978 substrate-Mg2+ binding site; other site 316274008979 aspartate-rich region 1; other site 316274008980 aspartate-rich region 2; other site 316274008981 aminodeoxychorismate synthase; Provisional; Region: PRK07508 316274008982 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316274008983 hypothetical protein; Provisional; Region: PRK07546 316274008984 substrate-cofactor binding pocket; other site 316274008985 homodimer interface [polypeptide binding]; other site 316274008986 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 316274008987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274008988 catalytic residue [active] 316274008989 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 316274008990 active site 316274008991 ribulose/triose binding site [chemical binding]; other site 316274008992 phosphate binding site [ion binding]; other site 316274008993 substrate (anthranilate) binding pocket [chemical binding]; other site 316274008994 product (indole) binding pocket [chemical binding]; other site 316274008995 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 316274008996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274008997 Walker A/P-loop; other site 316274008998 ATP binding site [chemical binding]; other site 316274008999 Q-loop/lid; other site 316274009000 ABC transporter signature motif; other site 316274009001 Walker B; other site 316274009002 D-loop; other site 316274009003 H-loop/switch region; other site 316274009004 ABC transporter; Region: ABC_tran_2; pfam12848 316274009005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274009006 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 316274009007 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316274009008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274009009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274009010 dimerization interface [polypeptide binding]; other site 316274009011 putative DNA binding site [nucleotide binding]; other site 316274009012 putative Zn2+ binding site [ion binding]; other site 316274009013 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 316274009014 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 316274009015 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 316274009016 CPxP motif; other site 316274009017 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316274009018 Found in ATP-dependent protease La (LON); Region: LON; smart00464 316274009019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274009020 Walker A motif; other site 316274009021 ATP binding site [chemical binding]; other site 316274009022 Walker B motif; other site 316274009023 arginine finger; other site 316274009024 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316274009025 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274009027 active site 316274009028 phosphorylation site [posttranslational modification] 316274009029 intermolecular recognition site; other site 316274009030 dimerization interface [polypeptide binding]; other site 316274009031 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274009032 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316274009033 putative RNA binding site [nucleotide binding]; other site 316274009034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274009035 S-adenosylmethionine binding site [chemical binding]; other site 316274009036 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 316274009037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009038 ATP binding site [chemical binding]; other site 316274009039 Mg2+ binding site [ion binding]; other site 316274009040 G-X-G motif; other site 316274009041 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 316274009042 ATP binding site [chemical binding]; other site 316274009043 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 316274009044 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 316274009045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 316274009046 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 316274009047 Walker A/P-loop; other site 316274009048 ATP binding site [chemical binding]; other site 316274009049 Q-loop/lid; other site 316274009050 ABC transporter signature motif; other site 316274009051 Walker B; other site 316274009052 D-loop; other site 316274009053 H-loop/switch region; other site 316274009054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274009055 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 316274009056 Walker A/P-loop; other site 316274009057 ATP binding site [chemical binding]; other site 316274009058 Q-loop/lid; other site 316274009059 ABC transporter signature motif; other site 316274009060 Walker B; other site 316274009061 D-loop; other site 316274009062 H-loop/switch region; other site 316274009063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274009064 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274009065 TM-ABC transporter signature motif; other site 316274009066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274009067 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274009068 TM-ABC transporter signature motif; other site 316274009069 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 316274009070 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316274009071 dimerization interface [polypeptide binding]; other site 316274009072 ligand binding site [chemical binding]; other site 316274009073 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 316274009074 ligand binding site [chemical binding]; other site 316274009075 putative catalytic site [active] 316274009076 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 316274009077 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 316274009078 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274009079 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316274009080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274009081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274009082 Walker A/P-loop; other site 316274009083 ATP binding site [chemical binding]; other site 316274009084 Q-loop/lid; other site 316274009085 ABC transporter signature motif; other site 316274009086 Walker B; other site 316274009087 D-loop; other site 316274009088 H-loop/switch region; other site 316274009089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274009090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274009091 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274009092 active site 316274009093 catalytic triad [active] 316274009094 CHASE4 domain; Region: CHASE4; pfam05228 316274009095 HAMP domain; Region: HAMP; pfam00672 316274009096 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009097 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 316274009098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274009100 motif II; other site 316274009101 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316274009102 metal binding site 2 [ion binding]; metal-binding site 316274009103 putative DNA binding helix; other site 316274009104 metal binding site 1 [ion binding]; metal-binding site 316274009105 dimer interface [polypeptide binding]; other site 316274009106 structural Zn2+ binding site [ion binding]; other site 316274009107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274009108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274009109 dimer interface [polypeptide binding]; other site 316274009110 phosphorylation site [posttranslational modification] 316274009111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009112 ATP binding site [chemical binding]; other site 316274009113 Mg2+ binding site [ion binding]; other site 316274009114 G-X-G motif; other site 316274009115 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 316274009116 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 316274009117 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 316274009118 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 316274009119 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 316274009120 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 316274009121 putative active site [active] 316274009122 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274009123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316274009124 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 316274009125 Catalytic site [active] 316274009126 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316274009127 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 316274009128 Catalytic site [active] 316274009129 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 316274009130 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 316274009131 Ligand Binding Site [chemical binding]; other site 316274009132 TilS substrate C-terminal domain; Region: TilS_C; smart00977 316274009133 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 316274009134 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274009135 active site 316274009136 FtsH Extracellular; Region: FtsH_ext; pfam06480 316274009137 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 316274009138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274009139 Walker A motif; other site 316274009140 ATP binding site [chemical binding]; other site 316274009141 Walker B motif; other site 316274009142 arginine finger; other site 316274009143 Peptidase family M41; Region: Peptidase_M41; pfam01434 316274009144 hypothetical protein; Validated; Region: PRK00110 316274009145 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274009146 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274009147 phosphopeptide binding site; other site 316274009148 von Willebrand factor type A domain; Region: VWA_2; pfam13519 316274009149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009150 active site 316274009151 ATP binding site [chemical binding]; other site 316274009152 substrate binding site [chemical binding]; other site 316274009153 activation loop (A-loop); other site 316274009154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274009155 active site 316274009156 Calx-beta domain; Region: Calx-beta; cl02522 316274009157 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 316274009158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009159 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009160 active site 316274009161 ATP binding site [chemical binding]; other site 316274009162 substrate binding site [chemical binding]; other site 316274009163 activation loop (A-loop); other site 316274009164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009166 active site 316274009167 ATP binding site [chemical binding]; other site 316274009168 substrate binding site [chemical binding]; other site 316274009169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274009170 substrate binding site [chemical binding]; other site 316274009171 activation loop (A-loop); other site 316274009172 activation loop (A-loop); other site 316274009173 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274009174 epoxyqueuosine reductase; Region: TIGR00276 316274009175 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 316274009176 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274009177 DNA methylase; Region: N6_N4_Mtase; pfam01555 316274009178 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274009179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274009180 ABC-ATPase subunit interface; other site 316274009181 dimer interface [polypeptide binding]; other site 316274009182 putative PBP binding regions; other site 316274009183 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274009184 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316274009185 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274009186 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316274009187 intersubunit interface [polypeptide binding]; other site 316274009188 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274009189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274009190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274009191 DNA binding residues [nucleotide binding] 316274009192 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274009193 translocation protein TolB; Provisional; Region: tolB; PRK04922 316274009194 mercuric reductase; Validated; Region: PRK06370 316274009195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274009196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316274009197 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274009198 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 316274009199 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 316274009200 ligand binding site [chemical binding]; other site 316274009201 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 316274009202 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316274009203 Walker A/P-loop; other site 316274009204 ATP binding site [chemical binding]; other site 316274009205 Q-loop/lid; other site 316274009206 ABC transporter signature motif; other site 316274009207 Walker B; other site 316274009208 D-loop; other site 316274009209 H-loop/switch region; other site 316274009210 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 316274009211 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274009212 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274009213 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274009214 TM-ABC transporter signature motif; other site 316274009215 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274009216 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 316274009217 TM-ABC transporter signature motif; other site 316274009218 CHAT domain; Region: CHAT; cl17868 316274009219 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 316274009220 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 316274009221 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 316274009222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 316274009223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274009224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274009225 active site 316274009226 phosphorylation site [posttranslational modification] 316274009227 intermolecular recognition site; other site 316274009228 dimerization interface [polypeptide binding]; other site 316274009229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274009230 DNA binding site [nucleotide binding] 316274009231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274009232 dimerization interface [polypeptide binding]; other site 316274009233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274009234 dimer interface [polypeptide binding]; other site 316274009235 phosphorylation site [posttranslational modification] 316274009236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009237 ATP binding site [chemical binding]; other site 316274009238 G-X-G motif; other site 316274009239 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316274009240 CoenzymeA binding site [chemical binding]; other site 316274009241 subunit interaction site [polypeptide binding]; other site 316274009242 PHB binding site; other site 316274009243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274009244 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 316274009245 active site 316274009246 motif I; other site 316274009247 motif II; other site 316274009248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274009249 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 316274009250 Peptidase family M50; Region: Peptidase_M50; pfam02163 316274009251 active site 316274009252 putative substrate binding region [chemical binding]; other site 316274009253 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316274009254 Double zinc ribbon; Region: DZR; pfam12773 316274009255 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274009256 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009258 active site 316274009259 ATP binding site [chemical binding]; other site 316274009260 substrate binding site [chemical binding]; other site 316274009261 activation loop (A-loop); other site 316274009262 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274009263 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274009264 Isochorismatase family; Region: Isochorismatase; pfam00857 316274009265 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 316274009266 catalytic triad [active] 316274009267 conserved cis-peptide bond; other site 316274009268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274009269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274009270 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 316274009271 Walker A/P-loop; other site 316274009272 ATP binding site [chemical binding]; other site 316274009273 Q-loop/lid; other site 316274009274 ABC transporter signature motif; other site 316274009275 Walker B; other site 316274009276 D-loop; other site 316274009277 H-loop/switch region; other site 316274009278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274009279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274009280 Cytochrome P450; Region: p450; cl12078 316274009281 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 316274009282 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274009283 active site 316274009284 homodimer interface [polypeptide binding]; other site 316274009285 catalytic site [active] 316274009286 Phospholipid methyltransferase; Region: PEMT; pfam04191 316274009287 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 316274009288 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316274009289 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316274009290 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316274009291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316274009292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316274009293 catalytic residue [active] 316274009294 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 316274009295 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 316274009296 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 316274009297 NADH dehydrogenase subunit B; Validated; Region: PRK06411 316274009298 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 316274009299 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 316274009300 NADH dehydrogenase subunit D; Validated; Region: PRK06075 316274009301 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 316274009302 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 316274009303 putative dimer interface [polypeptide binding]; other site 316274009304 [2Fe-2S] cluster binding site [ion binding]; other site 316274009305 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 316274009306 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4020; cl07907 316274009307 SLBB domain; Region: SLBB; pfam10531 316274009308 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316274009309 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 316274009310 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 316274009311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316274009312 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 316274009313 catalytic loop [active] 316274009314 iron binding site [ion binding]; other site 316274009315 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 316274009316 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316274009317 molybdopterin cofactor binding site; other site 316274009318 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316274009319 molybdopterin cofactor binding site; other site 316274009320 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 316274009321 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 316274009322 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274009323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316274009324 short chain dehydrogenase; Provisional; Region: PRK08303 316274009325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009326 NAD(P) binding site [chemical binding]; other site 316274009327 active site 316274009328 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 316274009329 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 316274009330 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274009332 active site 316274009333 phosphorylation site [posttranslational modification] 316274009334 intermolecular recognition site; other site 316274009335 dimerization interface [polypeptide binding]; other site 316274009336 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 316274009337 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 316274009338 RNA binding site [nucleotide binding]; other site 316274009339 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 316274009340 RNA binding site [nucleotide binding]; other site 316274009341 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316274009342 RNA binding site [nucleotide binding]; other site 316274009343 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 316274009344 metal ion-dependent adhesion site (MIDAS); other site 316274009345 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 316274009346 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 316274009347 Uncharacterized conserved protein [Function unknown]; Region: COG3342 316274009348 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 316274009349 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 316274009350 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 316274009351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274009352 S-adenosylmethionine binding site [chemical binding]; other site 316274009353 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274009354 SPFH domain / Band 7 family; Region: Band_7; pfam01145 316274009355 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 316274009356 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 316274009357 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274009358 Moco binding site; other site 316274009359 metal coordination site [ion binding]; other site 316274009360 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009361 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274009362 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009363 GAF domain; Region: GAF; pfam01590 316274009364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009365 GAF domain; Region: GAF; cl17456 316274009366 GAF domain; Region: GAF_3; pfam13492 316274009367 GAF domain; Region: GAF_2; pfam13185 316274009368 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274009369 PAS domain; Region: PAS_8; pfam13188 316274009370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274009371 dimer interface [polypeptide binding]; other site 316274009372 phosphorylation site [posttranslational modification] 316274009373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009374 ATP binding site [chemical binding]; other site 316274009375 Mg2+ binding site [ion binding]; other site 316274009376 G-X-G motif; other site 316274009377 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 316274009378 Protein export membrane protein; Region: SecD_SecF; cl14618 316274009379 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 316274009380 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 316274009381 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 316274009382 putative active site [active] 316274009383 Zn binding site [ion binding]; other site 316274009384 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 316274009385 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 316274009386 serine O-acetyltransferase; Region: cysE; TIGR01172 316274009387 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 316274009388 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 316274009389 trimer interface [polypeptide binding]; other site 316274009390 active site 316274009391 substrate binding site [chemical binding]; other site 316274009392 CoA binding site [chemical binding]; other site 316274009393 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 316274009394 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274009395 active site 316274009396 HIGH motif; other site 316274009397 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274009398 KMSKS motif; other site 316274009399 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 316274009400 tRNA binding surface [nucleotide binding]; other site 316274009401 anticodon binding site; other site 316274009402 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 316274009403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274009404 S-adenosylmethionine binding site [chemical binding]; other site 316274009405 RNA methyltransferase, RsmE family; Region: TIGR00046 316274009406 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 316274009407 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 316274009408 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 316274009409 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316274009410 protein binding site [polypeptide binding]; other site 316274009411 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 316274009412 Catalytic dyad [active] 316274009413 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 316274009414 tyramine oxidase; Provisional; Region: tynA; PRK11504 316274009415 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 316274009416 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 316274009417 oligoendopeptidase F; Region: pepF; TIGR00181 316274009418 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 316274009419 active site 316274009420 Zn binding site [ion binding]; other site 316274009421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274009422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274009423 Walker A/P-loop; other site 316274009424 ATP binding site [chemical binding]; other site 316274009425 Q-loop/lid; other site 316274009426 ABC transporter signature motif; other site 316274009427 Walker B; other site 316274009428 D-loop; other site 316274009429 H-loop/switch region; other site 316274009430 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274009431 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274009432 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274009433 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274009434 Integral membrane protein DUF95; Region: DUF95; pfam01944 316274009435 CHAT domain; Region: CHAT; cl17868 316274009436 recombination factor protein RarA; Reviewed; Region: PRK13342 316274009437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274009438 Walker A motif; other site 316274009439 ATP binding site [chemical binding]; other site 316274009440 Walker B motif; other site 316274009441 arginine finger; other site 316274009442 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 316274009443 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 316274009444 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 316274009445 Moco binding site; other site 316274009446 metal coordination site [ion binding]; other site 316274009447 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009448 Isochorismatase family; Region: Isochorismatase; pfam00857 316274009449 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 316274009450 catalytic triad [active] 316274009451 conserved cis-peptide bond; other site 316274009452 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316274009453 FAD binding domain; Region: FAD_binding_4; pfam01565 316274009454 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316274009455 Cysteine-rich domain; Region: CCG; pfam02754 316274009456 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274009457 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274009458 acyl-activating enzyme (AAE) consensus motif; other site 316274009459 AMP binding site [chemical binding]; other site 316274009460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274009461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274009462 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274009463 Condensation domain; Region: Condensation; pfam00668 316274009464 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274009465 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274009466 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274009467 acyl-activating enzyme (AAE) consensus motif; other site 316274009468 AMP binding site [chemical binding]; other site 316274009469 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274009470 Thioesterase domain; Region: Thioesterase; pfam00975 316274009471 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274009472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274009473 putative substrate translocation pore; other site 316274009474 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 316274009475 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 316274009476 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 316274009477 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 316274009478 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 316274009479 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274009480 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316274009481 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 316274009482 Walker A/P-loop; other site 316274009483 ATP binding site [chemical binding]; other site 316274009484 Q-loop/lid; other site 316274009485 ABC transporter signature motif; other site 316274009486 Walker B; other site 316274009487 D-loop; other site 316274009488 H-loop/switch region; other site 316274009489 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 316274009490 putative carbohydrate binding site [chemical binding]; other site 316274009491 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 316274009492 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 316274009493 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 316274009494 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274009495 Ligand binding site; other site 316274009496 Putative Catalytic site; other site 316274009497 DXD motif; other site 316274009498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274009499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274009500 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274009501 putative catalytic residues [active] 316274009502 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 316274009503 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 316274009504 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316274009505 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 316274009506 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316274009507 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274009508 Coenzyme A binding pocket [chemical binding]; other site 316274009509 cytidylate kinase; Provisional; Region: cmk; PRK00023 316274009510 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 316274009511 CMP-binding site; other site 316274009512 The sites determining sugar specificity; other site 316274009513 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316274009514 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316274009515 putative acyl-acceptor binding pocket; other site 316274009516 Bacterial PH domain; Region: DUF304; pfam03703 316274009517 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274009518 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274009519 Walker A/P-loop; other site 316274009520 ATP binding site [chemical binding]; other site 316274009521 Q-loop/lid; other site 316274009522 ABC transporter signature motif; other site 316274009523 Walker B; other site 316274009524 D-loop; other site 316274009525 H-loop/switch region; other site 316274009526 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274009527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274009528 Response regulator receiver domain; Region: Response_reg; pfam00072 316274009529 active site 316274009530 phosphorylation site [posttranslational modification] 316274009531 intermolecular recognition site; other site 316274009532 dimerization interface [polypeptide binding]; other site 316274009533 AAA ATPase domain; Region: AAA_16; pfam13191 316274009534 Predicted ATPase [General function prediction only]; Region: COG3903 316274009535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274009536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274009537 catalytic residues [active] 316274009538 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 316274009539 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274009540 DNA binding residues [nucleotide binding] 316274009541 putative dimer interface [polypeptide binding]; other site 316274009542 putative metal binding residues [ion binding]; other site 316274009543 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 316274009544 SpoOM protein; Region: Spo0M; pfam07070 316274009545 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 316274009546 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 316274009547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274009548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274009549 catalytic residue [active] 316274009550 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 316274009551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009552 NAD(P) binding site [chemical binding]; other site 316274009553 active site 316274009554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274009556 TPR motif; other site 316274009557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009558 binding surface 316274009559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274009560 binding surface 316274009561 TPR motif; other site 316274009562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274009565 binding surface 316274009566 TPR motif; other site 316274009567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009568 Probable zinc-binding domain; Region: zf-trcl; pfam13451 316274009569 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 316274009570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274009571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274009572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 316274009573 PAS domain; Region: PAS_8; pfam13188 316274009574 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009575 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 316274009576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316274009577 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274009578 metal ion-dependent adhesion site (MIDAS); other site 316274009579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274009580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274009581 active site 316274009582 ATP binding site [chemical binding]; other site 316274009583 substrate binding site [chemical binding]; other site 316274009584 activation loop (A-loop); other site 316274009585 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 316274009586 Zn binding sites [ion binding]; other site 316274009587 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 316274009588 dihydropteroate synthase; Region: DHPS; TIGR01496 316274009589 substrate binding pocket [chemical binding]; other site 316274009590 dimer interface [polypeptide binding]; other site 316274009591 inhibitor binding site; inhibition site 316274009592 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 316274009593 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 316274009594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274009595 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274009596 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 316274009597 NAD-dependent deacetylase; Provisional; Region: PRK00481 316274009598 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 316274009599 NAD+ binding site [chemical binding]; other site 316274009600 substrate binding site [chemical binding]; other site 316274009601 Zn binding site [ion binding]; other site 316274009602 NAD-dependent deacetylase; Provisional; Region: PRK00481 316274009603 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 316274009604 NAD+ binding site [chemical binding]; other site 316274009605 substrate binding site [chemical binding]; other site 316274009606 Zn binding site [ion binding]; other site 316274009607 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 316274009608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274009609 active site 316274009610 ATP binding site [chemical binding]; other site 316274009611 activation loop (A-loop); other site 316274009612 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274009613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274009614 S-adenosylmethionine binding site [chemical binding]; other site 316274009615 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274009616 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274009617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274009618 catalytic residue [active] 316274009619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274009620 HEAT repeats; Region: HEAT_2; pfam13646 316274009621 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 316274009622 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316274009623 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 316274009624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274009625 Walker A/P-loop; other site 316274009626 ATP binding site [chemical binding]; other site 316274009627 Q-loop/lid; other site 316274009628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274009629 ABC transporter signature motif; other site 316274009630 Walker B; other site 316274009631 D-loop; other site 316274009632 H-loop/switch region; other site 316274009633 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316274009634 B12 binding site [chemical binding]; other site 316274009635 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316274009636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274009637 FeS/SAM binding site; other site 316274009638 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 316274009639 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274009640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274009641 Walker A/P-loop; other site 316274009642 ATP binding site [chemical binding]; other site 316274009643 Q-loop/lid; other site 316274009644 ABC transporter signature motif; other site 316274009645 Walker B; other site 316274009646 D-loop; other site 316274009647 H-loop/switch region; other site 316274009648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316274009649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316274009650 substrate binding pocket [chemical binding]; other site 316274009651 membrane-bound complex binding site; other site 316274009652 hinge residues; other site 316274009653 phytoene desaturase; Region: crtI_fam; TIGR02734 316274009654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274009655 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 316274009656 ParB-like nuclease domain; Region: ParBc; pfam02195 316274009657 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274009658 active site 316274009659 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274009660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274009661 nucleotide binding site [chemical binding]; other site 316274009662 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 316274009663 GTP-binding protein LepA; Provisional; Region: PRK05433 316274009664 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 316274009665 G1 box; other site 316274009666 putative GEF interaction site [polypeptide binding]; other site 316274009667 GTP/Mg2+ binding site [chemical binding]; other site 316274009668 Switch I region; other site 316274009669 G2 box; other site 316274009670 G3 box; other site 316274009671 Switch II region; other site 316274009672 G4 box; other site 316274009673 G5 box; other site 316274009674 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 316274009675 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 316274009676 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 316274009677 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 316274009678 Protein of unknown function, DUF393; Region: DUF393; pfam04134 316274009679 Competence-damaged protein; Region: CinA; pfam02464 316274009680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 316274009681 AsnC family; Region: AsnC_trans_reg; pfam01037 316274009682 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 316274009683 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 316274009684 active site 316274009685 catalytic triad [active] 316274009686 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274009687 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 316274009688 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 316274009689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274009690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274009691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274009692 NAD(P) binding site [chemical binding]; other site 316274009693 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274009694 active site 316274009695 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 316274009696 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 316274009697 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274009698 nudix motif; other site 316274009699 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 316274009700 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 316274009701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 316274009702 nucleotide binding region [chemical binding]; other site 316274009703 SEC-C motif; Region: SEC-C; pfam02810 316274009704 gamma-glutamyl kinase; Provisional; Region: PRK05429 316274009705 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 316274009706 nucleotide binding site [chemical binding]; other site 316274009707 homotetrameric interface [polypeptide binding]; other site 316274009708 putative phosphate binding site [ion binding]; other site 316274009709 putative allosteric binding site; other site 316274009710 PUA domain; Region: PUA; pfam01472 316274009711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274009712 catalytic core [active] 316274009713 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 316274009714 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 316274009715 putative catalytic cysteine [active] 316274009716 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 316274009717 DNA binding residues [nucleotide binding] 316274009718 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 316274009719 dimer interface [polypeptide binding]; other site 316274009720 metal binding site [ion binding]; metal-binding site 316274009721 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316274009722 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274009723 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274009724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274009725 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 316274009726 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316274009727 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274009728 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 316274009729 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 316274009730 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 316274009731 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 316274009732 4Fe-4S binding domain; Region: Fer4; pfam00037 316274009733 4Fe-4S binding domain; Region: Fer4; pfam00037 316274009734 FOG: WD40-like repeat [Function unknown]; Region: COG1520 316274009735 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 316274009736 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 316274009737 PAS domain S-box; Region: sensory_box; TIGR00229 316274009738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274009739 putative active site [active] 316274009740 heme pocket [chemical binding]; other site 316274009741 PAS domain S-box; Region: sensory_box; TIGR00229 316274009742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274009743 putative active site [active] 316274009744 heme pocket [chemical binding]; other site 316274009745 GAF domain; Region: GAF_3; pfam13492 316274009746 GAF domain; Region: GAF_2; pfam13185 316274009747 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316274009748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274009749 Zn2+ binding site [ion binding]; other site 316274009750 Mg2+ binding site [ion binding]; other site 316274009751 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274009752 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 316274009753 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 316274009754 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316274009755 active site 316274009756 catalytic site [active] 316274009757 substrate binding site [chemical binding]; other site 316274009758 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 316274009759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274009760 putative Mg++ binding site [ion binding]; other site 316274009761 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 316274009762 Transglycosylase; Region: Transgly; pfam00912 316274009763 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 316274009764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316274009765 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 316274009766 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274009767 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316274009768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316274009769 protein binding site [polypeptide binding]; other site 316274009770 Predicted ATPase [General function prediction only]; Region: COG3903 316274009771 AAA domain; Region: AAA_14; pfam13173 316274009772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274009774 TPR motif; other site 316274009775 binding surface 316274009776 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274009777 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 316274009778 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 316274009779 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009780 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274009781 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009782 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274009783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 316274009784 Histidine kinase; Region: HisKA_2; pfam07568 316274009785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009786 ATP binding site [chemical binding]; other site 316274009787 Mg2+ binding site [ion binding]; other site 316274009788 G-X-G motif; other site 316274009789 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274009790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316274009791 active site 316274009792 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274009793 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274009794 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 316274009795 GTPase Era; Reviewed; Region: era; PRK00089 316274009796 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 316274009797 G1 box; other site 316274009798 GTP/Mg2+ binding site [chemical binding]; other site 316274009799 Switch I region; other site 316274009800 G2 box; other site 316274009801 Switch II region; other site 316274009802 G3 box; other site 316274009803 G4 box; other site 316274009804 G5 box; other site 316274009805 KH domain; Region: KH_2; pfam07650 316274009806 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274009807 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274009808 Uncharacterized conserved protein [Function unknown]; Region: COG0327 316274009809 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 316274009810 Uncharacterized conserved protein [Function unknown]; Region: COG2835 316274009811 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 316274009812 active site 316274009813 LabA_like proteins; Region: LabA_like; cd06167 316274009814 Uncharacterized conserved protein [Function unknown]; Region: COG1432 316274009815 putative metal binding site [ion binding]; other site 316274009816 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 316274009817 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 316274009818 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316274009819 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 316274009820 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 316274009821 NAD(P) binding site [chemical binding]; other site 316274009822 adenylosuccinate lyase; Provisional; Region: PRK09285 316274009823 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 316274009824 tetramer interface [polypeptide binding]; other site 316274009825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274009826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274009827 nucleotide binding site [chemical binding]; other site 316274009828 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274009829 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274009830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316274009831 structural tetrad; other site 316274009832 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274009833 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274009834 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 316274009835 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 316274009836 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 316274009837 NAD binding site [chemical binding]; other site 316274009838 homotetramer interface [polypeptide binding]; other site 316274009839 homodimer interface [polypeptide binding]; other site 316274009840 substrate binding site [chemical binding]; other site 316274009841 active site 316274009842 Predicted esterase [General function prediction only]; Region: COG0627 316274009843 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 316274009844 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 316274009845 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 316274009846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 316274009847 putative dimer interface [polypeptide binding]; other site 316274009848 active site pocket [active] 316274009849 putative cataytic base [active] 316274009850 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274009851 active site 316274009852 catalytic triad [active] 316274009853 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274009854 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274009855 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316274009856 ferredoxin-NADP+ reductase; Region: PLN02852 316274009857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274009858 FOG: CBS domain [General function prediction only]; Region: COG0517 316274009859 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 316274009860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274009861 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274009862 Predicted membrane protein [Function unknown]; Region: COG4270 316274009863 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 316274009864 intersubunit interface [polypeptide binding]; other site 316274009865 active site 316274009866 catalytic residue [active] 316274009867 Class I aldolases; Region: Aldolase_Class_I; cl17187 316274009868 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 316274009869 16S rRNA interaction site [nucleotide binding]; other site 316274009870 streptomycin interaction site [chemical binding]; other site 316274009871 23S rRNA interaction site [nucleotide binding]; other site 316274009872 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 316274009873 30S ribosomal protein S7; Validated; Region: PRK05302 316274009874 elongation factor G; Reviewed; Region: PRK00007 316274009875 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 316274009876 G1 box; other site 316274009877 putative GEF interaction site [polypeptide binding]; other site 316274009878 GTP/Mg2+ binding site [chemical binding]; other site 316274009879 Switch I region; other site 316274009880 G2 box; other site 316274009881 G3 box; other site 316274009882 Switch II region; other site 316274009883 G4 box; other site 316274009884 G5 box; other site 316274009885 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316274009886 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 316274009887 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316274009888 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274009889 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 316274009890 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 316274009891 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274009892 DNA binding residues [nucleotide binding] 316274009893 putative dimer interface [polypeptide binding]; other site 316274009894 putative metal binding residues [ion binding]; other site 316274009895 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316274009896 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274009897 metal-binding site [ion binding] 316274009898 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274009899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274009900 motif II; other site 316274009901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274009902 dimerization interface [polypeptide binding]; other site 316274009903 putative DNA binding site [nucleotide binding]; other site 316274009904 putative Zn2+ binding site [ion binding]; other site 316274009905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274009906 putative DNA binding site [nucleotide binding]; other site 316274009907 dimerization interface [polypeptide binding]; other site 316274009908 putative Zn2+ binding site [ion binding]; other site 316274009909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274009910 active site residue [active] 316274009911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316274009912 active site residue [active] 316274009913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274009914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274009915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274009916 putative substrate translocation pore; other site 316274009917 Thioredoxin; Region: Thioredoxin_4; pfam13462 316274009918 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316274009919 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 316274009920 YtkA-like; Region: YtkA; pfam13115 316274009921 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 316274009922 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274009923 GAF domain; Region: GAF; pfam01590 316274009924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274009925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274009926 putative active site [active] 316274009927 heme pocket [chemical binding]; other site 316274009928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274009929 dimer interface [polypeptide binding]; other site 316274009930 phosphorylation site [posttranslational modification] 316274009931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274009932 ATP binding site [chemical binding]; other site 316274009933 Mg2+ binding site [ion binding]; other site 316274009934 G-X-G motif; other site 316274009935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274009936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274009937 active site 316274009938 phosphorylation site [posttranslational modification] 316274009939 intermolecular recognition site; other site 316274009940 dimerization interface [polypeptide binding]; other site 316274009941 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274009942 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 316274009943 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 316274009944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 316274009945 active site 316274009946 dimerization interface [polypeptide binding]; other site 316274009947 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274009948 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274009949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274009950 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 316274009951 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 316274009952 active site 316274009953 catalytic residues [active] 316274009954 metal binding site [ion binding]; metal-binding site 316274009955 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 316274009956 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 316274009957 substrate binding site [chemical binding]; other site 316274009958 ligand binding site [chemical binding]; other site 316274009959 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 316274009960 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 316274009961 substrate binding site [chemical binding]; other site 316274009962 tartrate dehydrogenase; Region: TTC; TIGR02089 316274009963 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 316274009964 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 316274009965 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 316274009966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274009967 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316274009968 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316274009969 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 316274009970 putative nucleotide binding site [chemical binding]; other site 316274009971 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 316274009972 acetylornithine aminotransferase; Provisional; Region: PRK02627 316274009973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274009974 inhibitor-cofactor binding pocket; inhibition site 316274009975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274009976 catalytic residue [active] 316274009977 acetyl-lysine deacetylase; Provisional; Region: PRK04443 316274009978 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 316274009979 metal binding site [ion binding]; metal-binding site 316274009980 putative dimer interface [polypeptide binding]; other site 316274009981 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316274009982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274009983 active site 316274009984 metal binding site [ion binding]; metal-binding site 316274009985 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 316274009986 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 316274009987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274009988 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274009989 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 316274009990 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274009991 active site 316274009992 catalytic site [active] 316274009993 HEAT repeats; Region: HEAT_2; pfam13646 316274009994 Bacterial SH3 domain; Region: SH3_3; pfam08239 316274009995 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 316274009996 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316274009997 Walker A/P-loop; other site 316274009998 ATP binding site [chemical binding]; other site 316274009999 Q-loop/lid; other site 316274010000 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316274010001 Q-loop/lid; other site 316274010002 ABC transporter signature motif; other site 316274010003 Walker B; other site 316274010004 D-loop; other site 316274010005 H-loop/switch region; other site 316274010006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010007 TPR motif; other site 316274010008 binding surface 316274010009 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 316274010010 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 316274010011 Mg++ binding site [ion binding]; other site 316274010012 putative catalytic motif [active] 316274010013 substrate binding site [chemical binding]; other site 316274010014 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 316274010015 nudix motif; other site 316274010016 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 316274010017 homodimer interface [polypeptide binding]; other site 316274010018 chemical substrate binding site [chemical binding]; other site 316274010019 oligomer interface [polypeptide binding]; other site 316274010020 metal binding site [ion binding]; metal-binding site 316274010021 Helix-turn-helix domain; Region: HTH_28; pfam13518 316274010022 Winged helix-turn helix; Region: HTH_29; pfam13551 316274010023 Homeodomain-like domain; Region: HTH_32; pfam13565 316274010024 Integrase core domain; Region: rve; pfam00665 316274010025 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274010026 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274010027 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274010028 nudix motif; other site 316274010029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316274010030 classical (c) SDRs; Region: SDR_c; cd05233 316274010031 NAD(P) binding site [chemical binding]; other site 316274010032 active site 316274010033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274010034 dimerization interface [polypeptide binding]; other site 316274010035 putative DNA binding site [nucleotide binding]; other site 316274010036 putative Zn2+ binding site [ion binding]; other site 316274010037 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 316274010038 Low molecular weight phosphatase family; Region: LMWPc; cl00105 316274010039 active site 316274010040 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 316274010041 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316274010042 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316274010043 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 316274010044 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316274010045 dimer interface [polypeptide binding]; other site 316274010046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274010047 catalytic residue [active] 316274010048 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274010049 TrkA-N domain; Region: TrkA_N; pfam02254 316274010050 TrkA-C domain; Region: TrkA_C; pfam02080 316274010051 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316274010052 TrkA-N domain; Region: TrkA_N; pfam02254 316274010053 TrkA-C domain; Region: TrkA_C; pfam02080 316274010054 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 316274010055 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316274010056 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 316274010057 PAS domain S-box; Region: sensory_box; TIGR00229 316274010058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274010059 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 316274010060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010061 ATP binding site [chemical binding]; other site 316274010062 Mg2+ binding site [ion binding]; other site 316274010063 G-X-G motif; other site 316274010064 SEC-C motif; Region: SEC-C; pfam02810 316274010065 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274010066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274010067 DNA binding residues [nucleotide binding] 316274010068 dimerization interface [polypeptide binding]; other site 316274010069 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274010070 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274010071 Kelch domain; Region: Kelch; smart00612 316274010072 Kelch motif; Region: Kelch_1; pfam01344 316274010073 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316274010074 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 316274010075 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274010076 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 316274010077 active site 316274010078 metal binding site [ion binding]; metal-binding site 316274010079 Sporulation and spore germination; Region: Germane; pfam10646 316274010080 Sporulation and spore germination; Region: Germane; pfam10646 316274010081 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 316274010082 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 316274010083 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 316274010084 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 316274010085 RNA binding site [nucleotide binding]; other site 316274010086 Deoxyhypusine synthase; Region: DS; cl00826 316274010087 deoxyhypusine synthase; Region: dhys; TIGR00321 316274010088 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316274010089 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 316274010090 dimer interface [polypeptide binding]; other site 316274010091 acyl-activating enzyme (AAE) consensus motif; other site 316274010092 putative active site [active] 316274010093 AMP binding site [chemical binding]; other site 316274010094 putative CoA binding site [chemical binding]; other site 316274010095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274010096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274010097 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274010098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274010099 Walker A/P-loop; other site 316274010100 ATP binding site [chemical binding]; other site 316274010101 Q-loop/lid; other site 316274010102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274010103 ABC transporter signature motif; other site 316274010104 Walker B; other site 316274010105 D-loop; other site 316274010106 ABC transporter; Region: ABC_tran_2; pfam12848 316274010107 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274010108 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 316274010109 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 316274010110 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 316274010111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010112 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 316274010113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010114 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 316274010115 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274010116 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316274010117 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 316274010118 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 316274010119 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 316274010120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274010122 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274010123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274010124 S-adenosylmethionine binding site [chemical binding]; other site 316274010125 branched-chain amino acid aminotransferase; Validated; Region: PRK06606 316274010126 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 316274010127 homodimer interface [polypeptide binding]; other site 316274010128 substrate-cofactor binding pocket; other site 316274010129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274010130 catalytic residue [active] 316274010131 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316274010132 EamA-like transporter family; Region: EamA; pfam00892 316274010133 EamA-like transporter family; Region: EamA; pfam00892 316274010134 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316274010135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316274010136 DNA-binding site [nucleotide binding]; DNA binding site 316274010137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274010138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274010139 homodimer interface [polypeptide binding]; other site 316274010140 catalytic residue [active] 316274010141 CHASE3 domain; Region: CHASE3; pfam05227 316274010142 PAS fold; Region: PAS; pfam00989 316274010143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274010144 putative active site [active] 316274010145 heme pocket [chemical binding]; other site 316274010146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274010147 dimer interface [polypeptide binding]; other site 316274010148 phosphorylation site [posttranslational modification] 316274010149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010150 ATP binding site [chemical binding]; other site 316274010151 Mg2+ binding site [ion binding]; other site 316274010152 G-X-G motif; other site 316274010153 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 316274010154 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 316274010155 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316274010156 putative acyl-acceptor binding pocket; other site 316274010157 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 316274010158 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274010159 Ligand binding site; other site 316274010160 Putative Catalytic site; other site 316274010161 DXD motif; other site 316274010162 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 316274010163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274010164 active site 316274010165 motif I; other site 316274010166 motif II; other site 316274010167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274010168 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 316274010169 oligomerization interface [polypeptide binding]; other site 316274010170 active site 316274010171 metal binding site [ion binding]; metal-binding site 316274010172 Rossmann-like domain; Region: Rossmann-like; pfam10727 316274010173 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 316274010174 YhhN-like protein; Region: YhhN; pfam07947 316274010175 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 316274010176 Uncharacterized conserved protein [Function unknown]; Region: COG1359 316274010177 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316274010178 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274010179 transcription termination factor Rho; Provisional; Region: rho; PRK09376 316274010180 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 316274010181 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 316274010182 RNA binding site [nucleotide binding]; other site 316274010183 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 316274010184 multimer interface [polypeptide binding]; other site 316274010185 Walker A motif; other site 316274010186 ATP binding site [chemical binding]; other site 316274010187 Walker B motif; other site 316274010188 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 316274010189 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 316274010190 putative active site [active] 316274010191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274010192 Walker A motif; other site 316274010193 ATP binding site [chemical binding]; other site 316274010194 Walker B motif; other site 316274010195 arginine finger; other site 316274010196 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 316274010197 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 316274010198 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 316274010199 active site 316274010200 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 316274010201 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 316274010202 dimerization interface [polypeptide binding]; other site 316274010203 active site 316274010204 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274010205 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274010206 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 316274010207 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274010208 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274010209 Walker A/P-loop; other site 316274010210 ATP binding site [chemical binding]; other site 316274010211 Q-loop/lid; other site 316274010212 ABC transporter signature motif; other site 316274010213 Walker B; other site 316274010214 D-loop; other site 316274010215 H-loop/switch region; other site 316274010216 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 316274010217 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 316274010218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316274010219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274010220 dimerization interface [polypeptide binding]; other site 316274010221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274010222 putative active site [active] 316274010223 heme pocket [chemical binding]; other site 316274010224 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 316274010225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010226 ATP binding site [chemical binding]; other site 316274010227 Mg2+ binding site [ion binding]; other site 316274010228 G-X-G motif; other site 316274010229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274010230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010231 active site 316274010232 phosphorylation site [posttranslational modification] 316274010233 intermolecular recognition site; other site 316274010234 dimerization interface [polypeptide binding]; other site 316274010235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274010236 DNA binding site [nucleotide binding] 316274010237 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 316274010238 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 316274010239 dimer interface [polypeptide binding]; other site 316274010240 catalytic triad [active] 316274010241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274010242 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274010243 Probable transposase; Region: OrfB_IS605; pfam01385 316274010244 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 316274010245 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 316274010246 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316274010247 IHF - DNA interface [nucleotide binding]; other site 316274010248 IHF dimer interface [polypeptide binding]; other site 316274010249 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 316274010250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274010251 catalytic core [active] 316274010252 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 316274010253 conserved hypothetical protein; Region: TIGR03843 316274010254 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 316274010255 FMN binding site [chemical binding]; other site 316274010256 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 316274010257 dimer interface [polypeptide binding]; other site 316274010258 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274010259 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274010260 active site 316274010261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274010262 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316274010263 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 316274010264 Walker A motif; other site 316274010265 ATP binding site [chemical binding]; other site 316274010266 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 316274010267 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274010268 metal ion-dependent adhesion site (MIDAS); other site 316274010269 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316274010270 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 316274010271 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316274010272 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 316274010273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 316274010274 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 316274010275 Uncharacterized conserved protein [Function unknown]; Region: COG2308 316274010276 Uncharacterized conserved protein [Function unknown]; Region: COG1624 316274010277 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 316274010278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 316274010279 AAA domain; Region: AAA_22; pfam13401 316274010280 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 316274010281 G1 box; other site 316274010282 GTP/Mg2+ binding site [chemical binding]; other site 316274010283 Bacterial transcriptional activator domain; Region: BTAD; smart01043 316274010284 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 316274010285 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274010286 dimer interface [polypeptide binding]; other site 316274010287 putative metal binding site [ion binding]; other site 316274010288 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316274010289 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274010290 active site 316274010291 Substrate binding site; other site 316274010292 Mg++ binding site; other site 316274010293 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274010294 putative trimer interface [polypeptide binding]; other site 316274010295 putative CoA binding site [chemical binding]; other site 316274010296 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 316274010297 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 316274010298 septum formation inhibitor; Reviewed; Region: minC; PRK00513 316274010299 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 316274010300 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 316274010301 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 316274010302 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 316274010303 Switch I; other site 316274010304 Switch II; other site 316274010305 cell division topological specificity factor MinE; Provisional; Region: PRK13991 316274010306 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274010307 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316274010308 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274010309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274010310 metal binding site [ion binding]; metal-binding site 316274010311 active site 316274010312 I-site; other site 316274010313 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316274010314 Walker A motif; other site 316274010315 ATP binding site [chemical binding]; other site 316274010316 Walker B motif; other site 316274010317 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274010318 Protein of unknown function (DUF461); Region: DUF461; pfam04314 316274010319 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 316274010320 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 316274010321 Cu(I) binding site [ion binding]; other site 316274010322 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316274010323 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274010324 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316274010325 putative active site [active] 316274010326 CpXC protein; Region: CpXC; pfam14353 316274010327 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 316274010328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274010329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274010330 DNA binding residues [nucleotide binding] 316274010331 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 316274010332 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 316274010333 AAA domain; Region: AAA_33; pfam13671 316274010334 ATP-binding site [chemical binding]; other site 316274010335 SWIM zinc finger; Region: SWIM; pfam04434 316274010336 ski2-like helicase; Provisional; Region: PRK01172 316274010337 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 316274010338 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 316274010339 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 316274010340 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 316274010341 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 316274010342 trmE is a tRNA modification GTPase; Region: trmE; cd04164 316274010343 G1 box; other site 316274010344 GTP/Mg2+ binding site [chemical binding]; other site 316274010345 Switch I region; other site 316274010346 G2 box; other site 316274010347 Switch II region; other site 316274010348 G3 box; other site 316274010349 G4 box; other site 316274010350 G5 box; other site 316274010351 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 316274010352 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274010353 acylphosphatase; Provisional; Region: PRK14444 316274010354 DJ-1 family protein; Region: not_thiJ; TIGR01383 316274010355 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 316274010356 conserved cys residue [active] 316274010357 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316274010358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274010359 dimer interface [polypeptide binding]; other site 316274010360 conserved gate region; other site 316274010361 putative PBP binding loops; other site 316274010362 ABC-ATPase subunit interface; other site 316274010363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274010364 dimer interface [polypeptide binding]; other site 316274010365 conserved gate region; other site 316274010366 putative PBP binding loops; other site 316274010367 ABC-ATPase subunit interface; other site 316274010368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274010369 dimerization interface [polypeptide binding]; other site 316274010370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274010371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274010372 dimer interface [polypeptide binding]; other site 316274010373 phosphorylation site [posttranslational modification] 316274010374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010375 ATP binding site [chemical binding]; other site 316274010376 Mg2+ binding site [ion binding]; other site 316274010377 G-X-G motif; other site 316274010378 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010380 active site 316274010381 phosphorylation site [posttranslational modification] 316274010382 intermolecular recognition site; other site 316274010383 dimerization interface [polypeptide binding]; other site 316274010384 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010386 active site 316274010387 phosphorylation site [posttranslational modification] 316274010388 intermolecular recognition site; other site 316274010389 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316274010390 putative active site [active] 316274010391 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274010392 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 316274010393 catalytic site [active] 316274010394 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 316274010395 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 316274010396 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316274010397 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 316274010398 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 316274010399 catalytic residues [active] 316274010400 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 316274010401 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274010402 active site 316274010403 metal binding site [ion binding]; metal-binding site 316274010404 DNA binding site [nucleotide binding] 316274010405 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 316274010406 L-aspartate oxidase; Provisional; Region: PRK06175 316274010407 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316274010408 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 316274010409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316274010410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316274010411 dimerization interface [polypeptide binding]; other site 316274010412 Bacterial Ig-like domain; Region: Big_5; pfam13205 316274010413 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 316274010414 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010416 active site 316274010417 phosphorylation site [posttranslational modification] 316274010418 intermolecular recognition site; other site 316274010419 dimerization interface [polypeptide binding]; other site 316274010420 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010421 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274010422 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010423 GAF domain; Region: GAF_3; pfam13492 316274010424 PAS domain; Region: PAS; smart00091 316274010425 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274010426 putative active site [active] 316274010427 heme pocket [chemical binding]; other site 316274010428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274010429 dimer interface [polypeptide binding]; other site 316274010430 phosphorylation site [posttranslational modification] 316274010431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010432 ATP binding site [chemical binding]; other site 316274010433 Mg2+ binding site [ion binding]; other site 316274010434 G-X-G motif; other site 316274010435 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010437 active site 316274010438 phosphorylation site [posttranslational modification] 316274010439 intermolecular recognition site; other site 316274010440 dimerization interface [polypeptide binding]; other site 316274010441 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010442 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274010443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274010444 dimer interface [polypeptide binding]; other site 316274010445 phosphorylation site [posttranslational modification] 316274010446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010447 ATP binding site [chemical binding]; other site 316274010448 Mg2+ binding site [ion binding]; other site 316274010449 G-X-G motif; other site 316274010450 pantoate--beta-alanine ligase; Region: panC; TIGR00018 316274010451 Pantoate-beta-alanine ligase; Region: PanC; cd00560 316274010452 active site 316274010453 ATP-binding site [chemical binding]; other site 316274010454 pantoate-binding site; other site 316274010455 HXXH motif; other site 316274010456 Cellulose binding domain; Region: CBM_2; pfam00553 316274010457 Pectate lyase; Region: Pec_lyase_C; cl01593 316274010458 Cellulose binding domain; Region: CBM_2; pfam00553 316274010459 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 316274010460 metal binding site [ion binding]; metal-binding site 316274010461 active site 316274010462 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 316274010463 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 316274010464 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 316274010465 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 316274010466 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 316274010467 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 316274010468 SPFH domain / Band 7 family; Region: Band_7; pfam01145 316274010469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316274010470 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274010471 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 316274010472 substrate binding site [chemical binding]; other site 316274010473 ATP binding site [chemical binding]; other site 316274010474 Response regulator receiver domain; Region: Response_reg; pfam00072 316274010475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010476 active site 316274010477 phosphorylation site [posttranslational modification] 316274010478 intermolecular recognition site; other site 316274010479 dimerization interface [polypeptide binding]; other site 316274010480 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274010481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274010482 metal binding site [ion binding]; metal-binding site 316274010483 active site 316274010484 I-site; other site 316274010485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010486 binding surface 316274010487 TPR motif; other site 316274010488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010489 binding surface 316274010490 TPR motif; other site 316274010491 TPR repeat; Region: TPR_11; pfam13414 316274010492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010493 binding surface 316274010494 TPR motif; other site 316274010495 TPR repeat; Region: TPR_11; pfam13414 316274010496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010497 binding surface 316274010498 TPR motif; other site 316274010499 TPR repeat; Region: TPR_11; pfam13414 316274010500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010501 binding surface 316274010502 TPR motif; other site 316274010503 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274010504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010505 binding surface 316274010506 TPR motif; other site 316274010507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010508 binding surface 316274010509 TPR motif; other site 316274010510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274010511 acyl-coenzyme A oxidase; Region: PLN02526 316274010512 active site 316274010513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274010514 S-adenosylmethionine binding site [chemical binding]; other site 316274010515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274010517 active site 316274010518 ATP binding site [chemical binding]; other site 316274010519 substrate binding site [chemical binding]; other site 316274010520 activation loop (A-loop); other site 316274010521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010522 TPR motif; other site 316274010523 binding surface 316274010524 TPR repeat; Region: TPR_11; pfam13414 316274010525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010526 binding surface 316274010527 TPR motif; other site 316274010528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010529 TPR motif; other site 316274010530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010531 binding surface 316274010532 TPR repeat; Region: TPR_11; pfam13414 316274010533 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 316274010534 active site 316274010535 catalytic residues [active] 316274010536 metal binding site [ion binding]; metal-binding site 316274010537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274010538 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 316274010539 AAA ATPase domain; Region: AAA_16; pfam13191 316274010540 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274010541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274010542 DNA binding residues [nucleotide binding] 316274010543 dimerization interface [polypeptide binding]; other site 316274010544 GMP synthase; Reviewed; Region: guaA; PRK00074 316274010545 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 316274010546 AMP/PPi binding site [chemical binding]; other site 316274010547 candidate oxyanion hole; other site 316274010548 catalytic triad [active] 316274010549 potential glutamine specificity residues [chemical binding]; other site 316274010550 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 316274010551 ATP Binding subdomain [chemical binding]; other site 316274010552 Ligand Binding sites [chemical binding]; other site 316274010553 Dimerization subdomain; other site 316274010554 Predicted membrane protein [Function unknown]; Region: COG2860 316274010555 UPF0126 domain; Region: UPF0126; pfam03458 316274010556 UPF0126 domain; Region: UPF0126; pfam03458 316274010557 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316274010558 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274010559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274010561 active site 316274010562 ATP binding site [chemical binding]; other site 316274010563 substrate binding site [chemical binding]; other site 316274010564 activation loop (A-loop); other site 316274010565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010566 binding surface 316274010567 TPR motif; other site 316274010568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274010569 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274010570 active site 316274010571 ATP binding site [chemical binding]; other site 316274010572 substrate binding site [chemical binding]; other site 316274010573 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274010574 substrate binding site [chemical binding]; other site 316274010575 activation loop (A-loop); other site 316274010576 activation loop (A-loop); other site 316274010577 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 316274010578 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274010579 metal-dependent hydrolase; Provisional; Region: PRK13291 316274010580 DinB superfamily; Region: DinB_2; pfam12867 316274010581 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 316274010582 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 316274010583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010584 TPR motif; other site 316274010585 binding surface 316274010586 TPR repeat; Region: TPR_11; pfam13414 316274010587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274010588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274010589 Coenzyme A binding pocket [chemical binding]; other site 316274010590 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274010591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274010592 S-adenosylmethionine binding site [chemical binding]; other site 316274010593 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316274010594 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316274010595 active site 316274010596 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316274010597 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274010598 putative RNA binding site [nucleotide binding]; other site 316274010599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274010600 S-adenosylmethionine binding site [chemical binding]; other site 316274010601 ScpA/B protein; Region: ScpA_ScpB; cl00598 316274010602 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 316274010603 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 316274010604 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 316274010605 NAD(P) binding site [chemical binding]; other site 316274010606 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 316274010607 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274010608 peptide binding site [polypeptide binding]; other site 316274010609 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274010610 dimer interface [polypeptide binding]; other site 316274010611 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 316274010612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274010613 Walker A/P-loop; other site 316274010614 ATP binding site [chemical binding]; other site 316274010615 Q-loop/lid; other site 316274010616 ABC transporter signature motif; other site 316274010617 Walker B; other site 316274010618 D-loop; other site 316274010619 H-loop/switch region; other site 316274010620 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316274010621 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316274010622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316274010623 Walker A/P-loop; other site 316274010624 ATP binding site [chemical binding]; other site 316274010625 Q-loop/lid; other site 316274010626 ABC transporter signature motif; other site 316274010627 Walker B; other site 316274010628 D-loop; other site 316274010629 H-loop/switch region; other site 316274010630 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316274010631 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274010632 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274010633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274010634 dimer interface [polypeptide binding]; other site 316274010635 conserved gate region; other site 316274010636 putative PBP binding loops; other site 316274010637 ABC-ATPase subunit interface; other site 316274010638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274010639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274010640 dimer interface [polypeptide binding]; other site 316274010641 conserved gate region; other site 316274010642 putative PBP binding loops; other site 316274010643 ABC-ATPase subunit interface; other site 316274010644 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274010645 peptide binding site [polypeptide binding]; other site 316274010646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274010647 dimer interface [polypeptide binding]; other site 316274010648 cell division protein FtsZ; Validated; Region: PRK09330 316274010649 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 316274010650 nucleotide binding site [chemical binding]; other site 316274010651 SulA interaction site; other site 316274010652 cell division protein FtsA; Region: ftsA; TIGR01174 316274010653 Cell division protein FtsA; Region: FtsA; smart00842 316274010654 Cell division protein FtsA; Region: FtsA; pfam14450 316274010655 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 316274010656 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 316274010657 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 316274010658 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 316274010659 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 316274010660 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 316274010661 FAD binding domain; Region: FAD_binding_4; pfam01565 316274010662 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 316274010663 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010666 binding surface 316274010667 TPR motif; other site 316274010668 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010669 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 316274010670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274010671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274010672 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 316274010673 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 316274010674 homodimer interface [polypeptide binding]; other site 316274010675 active site 316274010676 cell division protein FtsW; Region: ftsW; TIGR02614 316274010677 Rhomboid family; Region: Rhomboid; pfam01694 316274010678 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 316274010679 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 316274010680 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274010681 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 316274010682 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 316274010683 Mg++ binding site [ion binding]; other site 316274010684 putative catalytic motif [active] 316274010685 putative substrate binding site [chemical binding]; other site 316274010686 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 316274010687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274010688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274010689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274010690 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 316274010691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274010692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316274010693 MraW methylase family; Region: Methyltransf_5; pfam01795 316274010694 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 316274010695 cell division protein MraZ; Reviewed; Region: PRK00326 316274010696 MraZ protein; Region: MraZ; pfam02381 316274010697 MraZ protein; Region: MraZ; pfam02381 316274010698 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316274010699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010700 GAF domain; Region: GAF_3; pfam13492 316274010701 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274010702 GAF domain; Region: GAF_3; pfam13492 316274010703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274010704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274010705 dimer interface [polypeptide binding]; other site 316274010706 phosphorylation site [posttranslational modification] 316274010707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274010708 ATP binding site [chemical binding]; other site 316274010709 Mg2+ binding site [ion binding]; other site 316274010710 G-X-G motif; other site 316274010711 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274010712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274010713 active site 316274010714 phosphorylation site [posttranslational modification] 316274010715 intermolecular recognition site; other site 316274010716 dimerization interface [polypeptide binding]; other site 316274010717 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 316274010718 putative active site [active] 316274010719 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 316274010720 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274010721 Phosphotransferase enzyme family; Region: APH; pfam01636 316274010722 active site 316274010723 substrate binding site [chemical binding]; other site 316274010724 ATP binding site [chemical binding]; other site 316274010725 PAS fold; Region: PAS_4; pfam08448 316274010726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274010727 putative active site [active] 316274010728 heme pocket [chemical binding]; other site 316274010729 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316274010730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 316274010731 putative active site [active] 316274010732 heme pocket [chemical binding]; other site 316274010733 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 316274010734 PAS fold; Region: PAS_3; pfam08447 316274010735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274010736 putative active site [active] 316274010737 heme pocket [chemical binding]; other site 316274010738 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274010739 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 316274010740 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 316274010741 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 316274010742 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 316274010743 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 316274010744 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 316274010745 Walker A motif; other site 316274010746 ATP binding site [chemical binding]; other site 316274010747 Walker B motif; other site 316274010748 DNA binding loops [nucleotide binding] 316274010749 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 316274010750 protein-splicing catalytic site; other site 316274010751 thioester formation/cholesterol transfer; other site 316274010752 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316274010753 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274010754 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274010755 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 316274010756 Divergent AAA domain; Region: AAA_4; pfam04326 316274010757 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 316274010758 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 316274010759 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316274010760 putative acyl-acceptor binding pocket; other site 316274010761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 316274010762 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 316274010763 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 316274010764 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 316274010765 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 316274010766 homodimer interface [polypeptide binding]; other site 316274010767 catalytic residues [active] 316274010768 NAD binding site [chemical binding]; other site 316274010769 substrate binding pocket [chemical binding]; other site 316274010770 flexible flap; other site 316274010771 MG2 domain; Region: A2M_N; pfam01835 316274010772 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274010773 active site 316274010774 catalytic triad [active] 316274010775 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 316274010776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274010777 DNA binding residues [nucleotide binding] 316274010778 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 316274010779 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 316274010780 tRNA; other site 316274010781 putative tRNA binding site [nucleotide binding]; other site 316274010782 putative NADP binding site [chemical binding]; other site 316274010783 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 316274010784 Chlorite dismutase; Region: Chlor_dismutase; cl01280 316274010785 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 316274010786 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 316274010787 substrate binding site [chemical binding]; other site 316274010788 active site 316274010789 Ferrochelatase; Region: Ferrochelatase; pfam00762 316274010790 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 316274010791 C-terminal domain interface [polypeptide binding]; other site 316274010792 active site 316274010793 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 316274010794 active site 316274010795 N-terminal domain interface [polypeptide binding]; other site 316274010796 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 316274010797 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 316274010798 domain interfaces; other site 316274010799 active site 316274010800 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 316274010801 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 316274010802 active site 316274010803 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 316274010804 dimer interface [polypeptide binding]; other site 316274010805 active site 316274010806 Schiff base residues; other site 316274010807 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 316274010808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274010809 inhibitor-cofactor binding pocket; inhibition site 316274010810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274010811 catalytic residue [active] 316274010812 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316274010813 putative catalytic site [active] 316274010814 putative metal binding site [ion binding]; other site 316274010815 putative phosphate binding site [ion binding]; other site 316274010816 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274010817 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316274010818 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274010819 motif 1; other site 316274010820 dimer interface [polypeptide binding]; other site 316274010821 active site 316274010822 motif 2; other site 316274010823 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 316274010824 putative deacylase active site [active] 316274010825 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274010826 active site 316274010827 motif 3; other site 316274010828 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 316274010829 anticodon binding site; other site 316274010830 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 316274010831 pyrroline-5-carboxylate reductase; Region: PLN02688 316274010832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274010833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274010834 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274010835 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274010836 active site 316274010837 GTP-binding protein Der; Reviewed; Region: PRK00093 316274010838 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 316274010839 G1 box; other site 316274010840 GTP/Mg2+ binding site [chemical binding]; other site 316274010841 Switch I region; other site 316274010842 G2 box; other site 316274010843 Switch II region; other site 316274010844 G3 box; other site 316274010845 G4 box; other site 316274010846 G5 box; other site 316274010847 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 316274010848 G1 box; other site 316274010849 GTP/Mg2+ binding site [chemical binding]; other site 316274010850 Switch I region; other site 316274010851 G2 box; other site 316274010852 G3 box; other site 316274010853 Switch II region; other site 316274010854 G4 box; other site 316274010855 G5 box; other site 316274010856 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 316274010857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274010858 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274010859 GAF domain; Region: GAF; pfam01590 316274010860 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316274010861 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274010862 Zn2+ binding site [ion binding]; other site 316274010863 Mg2+ binding site [ion binding]; other site 316274010864 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316274010865 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 316274010866 Protein of unknown function (DUF512); Region: DUF512; pfam04459 316274010867 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 316274010868 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316274010869 ATP binding site [chemical binding]; other site 316274010870 Mg2+ binding site [ion binding]; other site 316274010871 G-X-G motif; other site 316274010872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274010873 metal binding site [ion binding]; metal-binding site 316274010874 active site 316274010875 I-site; other site 316274010876 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316274010877 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 316274010878 putative ADP-binding pocket [chemical binding]; other site 316274010879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010880 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274010881 Chain length determinant protein; Region: Wzz; cl15801 316274010882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274010883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274010884 active site 316274010885 I-site; other site 316274010886 metal binding site [ion binding]; metal-binding site 316274010887 O-Antigen ligase; Region: Wzy_C; cl04850 316274010888 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316274010889 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 316274010890 colanic acid exporter; Provisional; Region: PRK10459 316274010891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010892 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 316274010893 putative ADP-binding pocket [chemical binding]; other site 316274010894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274010895 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274010896 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 316274010897 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274010898 DXD motif; other site 316274010899 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274010900 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274010901 active site 316274010902 dimer interface [polypeptide binding]; other site 316274010903 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 316274010904 Ligand Binding Site [chemical binding]; other site 316274010905 Molecular Tunnel; other site 316274010906 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 316274010907 Double zinc ribbon; Region: DZR; pfam12773 316274010908 cyclase homology domain; Region: CHD; cd07302 316274010909 nucleotidyl binding site; other site 316274010910 metal binding site [ion binding]; metal-binding site 316274010911 dimer interface [polypeptide binding]; other site 316274010912 AAA ATPase domain; Region: AAA_16; pfam13191 316274010913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010914 TPR motif; other site 316274010915 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010916 binding surface 316274010917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274010919 binding surface 316274010920 TPR motif; other site 316274010921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274010924 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 316274010925 active site 316274010926 catalytic triad [active] 316274010927 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316274010928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274010929 putative active site [active] 316274010930 putative metal binding site [ion binding]; other site 316274010931 Protease prsW family; Region: PrsW-protease; pfam13367 316274010932 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316274010933 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316274010934 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316274010935 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 316274010936 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 316274010937 active site 316274010938 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316274010939 NlpC/P60 family; Region: NLPC_P60; pfam00877 316274010940 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 316274010941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274010942 Walker A/P-loop; other site 316274010943 ATP binding site [chemical binding]; other site 316274010944 Q-loop/lid; other site 316274010945 ABC transporter signature motif; other site 316274010946 Walker B; other site 316274010947 D-loop; other site 316274010948 H-loop/switch region; other site 316274010949 GTPase RsgA; Reviewed; Region: PRK00098 316274010950 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 316274010951 RNA binding site [nucleotide binding]; other site 316274010952 homodimer interface [polypeptide binding]; other site 316274010953 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 316274010954 GTPase/Zn-binding domain interface [polypeptide binding]; other site 316274010955 GTP/Mg2+ binding site [chemical binding]; other site 316274010956 G4 box; other site 316274010957 G5 box; other site 316274010958 G1 box; other site 316274010959 Switch I region; other site 316274010960 G2 box; other site 316274010961 G3 box; other site 316274010962 Switch II region; other site 316274010963 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 316274010964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274010965 Walker A motif; other site 316274010966 ATP binding site [chemical binding]; other site 316274010967 Walker B motif; other site 316274010968 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316274010969 Bacterial SH3 domain; Region: SH3_3; cl17532 316274010970 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274010971 catalytic core [active] 316274010972 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 316274010973 active site 316274010974 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274010975 active site clefts [active] 316274010976 zinc binding site [ion binding]; other site 316274010977 dimer interface [polypeptide binding]; other site 316274010978 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316274010979 active site clefts [active] 316274010980 zinc binding site [ion binding]; other site 316274010981 dimer interface [polypeptide binding]; other site 316274010982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274010983 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 316274010984 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 316274010985 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274010986 catalytic residues [active] 316274010987 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 316274010988 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274010989 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 316274010990 AzlC protein; Region: AzlC; pfam03591 316274010991 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 316274010992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274010993 dimerization interface [polypeptide binding]; other site 316274010994 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274010995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274010996 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274010997 nucleotide binding site [chemical binding]; other site 316274010998 Type III pantothenate kinase; Region: Pan_kinase; cl17198 316274010999 Nuclease-related domain; Region: NERD; pfam08378 316274011000 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 316274011001 AAA domain; Region: AAA_30; pfam13604 316274011002 Family description; Region: UvrD_C_2; pfam13538 316274011003 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 316274011004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274011005 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 316274011006 Cupin domain; Region: Cupin_2; cl17218 316274011007 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 316274011008 putative metal binding site [ion binding]; other site 316274011009 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 316274011010 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 316274011011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011012 Coenzyme A binding pocket [chemical binding]; other site 316274011013 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 316274011014 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 316274011015 CoA-transferase family III; Region: CoA_transf_3; pfam02515 316274011016 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274011017 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011018 Predicted membrane protein [Function unknown]; Region: COG2246 316274011019 GtrA-like protein; Region: GtrA; pfam04138 316274011020 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274011021 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274011022 Ligand binding site; other site 316274011023 Putative Catalytic site; other site 316274011024 DXD motif; other site 316274011025 DinB superfamily; Region: DinB_2; pfam12867 316274011026 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274011027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274011028 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316274011029 Walker A/P-loop; other site 316274011030 ATP binding site [chemical binding]; other site 316274011031 Q-loop/lid; other site 316274011032 ABC transporter signature motif; other site 316274011033 Walker B; other site 316274011034 D-loop; other site 316274011035 H-loop/switch region; other site 316274011036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316274011037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274011038 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316274011039 Walker A/P-loop; other site 316274011040 ATP binding site [chemical binding]; other site 316274011041 Q-loop/lid; other site 316274011042 ABC transporter signature motif; other site 316274011043 Walker B; other site 316274011044 D-loop; other site 316274011045 H-loop/switch region; other site 316274011046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274011047 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011048 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 316274011049 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 316274011050 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 316274011051 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 316274011052 FAD binding site [chemical binding]; other site 316274011053 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 316274011054 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 316274011055 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 316274011056 motif 1; other site 316274011057 active site 316274011058 motif 2; other site 316274011059 motif 3; other site 316274011060 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 316274011061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011062 Coenzyme A binding pocket [chemical binding]; other site 316274011063 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 316274011064 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 316274011065 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 316274011066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274011067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274011068 dimer interface [polypeptide binding]; other site 316274011069 conserved gate region; other site 316274011070 putative PBP binding loops; other site 316274011071 ABC-ATPase subunit interface; other site 316274011072 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 316274011073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274011074 dimer interface [polypeptide binding]; other site 316274011075 conserved gate region; other site 316274011076 putative PBP binding loops; other site 316274011077 ABC-ATPase subunit interface; other site 316274011078 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274011079 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 316274011080 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 316274011081 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 316274011082 active site 316274011083 substrate binding site [chemical binding]; other site 316274011084 Mg2+ binding site [ion binding]; other site 316274011085 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 316274011086 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 316274011087 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 316274011088 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 316274011089 active site 316274011090 Zn binding site [ion binding]; other site 316274011091 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 316274011092 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 316274011093 Competence protein; Region: Competence; pfam03772 316274011094 Cupin domain; Region: Cupin_2; cl17218 316274011095 Bacterial SH3 domain; Region: SH3_4; pfam06347 316274011096 Bacterial SH3 domain; Region: SH3_3; pfam08239 316274011097 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316274011098 NlpC/P60 family; Region: NLPC_P60; pfam00877 316274011099 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011100 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 316274011101 Part of AAA domain; Region: AAA_19; pfam13245 316274011102 Family description; Region: UvrD_C_2; pfam13538 316274011103 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 316274011104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274011105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274011106 active site 316274011107 phosphorylation site [posttranslational modification] 316274011108 intermolecular recognition site; other site 316274011109 dimerization interface [polypeptide binding]; other site 316274011110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274011111 DNA binding residues [nucleotide binding] 316274011112 dimerization interface [polypeptide binding]; other site 316274011113 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316274011114 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 316274011115 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274011116 putative ligand binding site [chemical binding]; other site 316274011117 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 316274011118 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316274011119 Walker A/P-loop; other site 316274011120 ATP binding site [chemical binding]; other site 316274011121 Q-loop/lid; other site 316274011122 ABC transporter signature motif; other site 316274011123 Walker B; other site 316274011124 D-loop; other site 316274011125 H-loop/switch region; other site 316274011126 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 316274011127 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274011128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274011129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274011130 TM-ABC transporter signature motif; other site 316274011131 ribulokinase; Provisional; Region: PRK04123 316274011132 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 316274011133 N- and C-terminal domain interface [polypeptide binding]; other site 316274011134 active site 316274011135 MgATP binding site [chemical binding]; other site 316274011136 catalytic site [active] 316274011137 metal binding site [ion binding]; metal-binding site 316274011138 carbohydrate binding site [chemical binding]; other site 316274011139 homodimer interface [polypeptide binding]; other site 316274011140 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 316274011141 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 316274011142 intersubunit interface [polypeptide binding]; other site 316274011143 active site 316274011144 Zn2+ binding site [ion binding]; other site 316274011145 L-arabinose isomerase; Provisional; Region: PRK02929 316274011146 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 316274011147 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 316274011148 trimer interface [polypeptide binding]; other site 316274011149 putative substrate binding site [chemical binding]; other site 316274011150 putative metal binding site [ion binding]; other site 316274011151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274011152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274011153 DNA binding site [nucleotide binding] 316274011154 domain linker motif; other site 316274011155 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 316274011156 putative dimerization interface [polypeptide binding]; other site 316274011157 putative ligand binding site [chemical binding]; other site 316274011158 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 316274011159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 316274011160 aspartate aminotransferase; Provisional; Region: PRK05764 316274011161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274011162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274011163 homodimer interface [polypeptide binding]; other site 316274011164 catalytic residue [active] 316274011165 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274011166 catalytic core [active] 316274011167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011168 AAA domain; Region: AAA_21; pfam13304 316274011169 Walker A/P-loop; other site 316274011170 ATP binding site [chemical binding]; other site 316274011171 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 316274011172 active site 316274011173 metal binding site [ion binding]; metal-binding site 316274011174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316274011175 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316274011176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274011177 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 316274011178 oligomerisation interface [polypeptide binding]; other site 316274011179 mobile loop; other site 316274011180 roof hairpin; other site 316274011181 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 316274011182 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 316274011183 ring oligomerisation interface [polypeptide binding]; other site 316274011184 ATP/Mg binding site [chemical binding]; other site 316274011185 stacking interactions; other site 316274011186 hinge regions; other site 316274011187 dihydrodipicolinate reductase; Provisional; Region: PRK00048 316274011188 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 316274011189 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 316274011190 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274011191 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 316274011192 AAA ATPase domain; Region: AAA_16; pfam13191 316274011193 Protein of unknown function (DUF1670); Region: DUF1670; pfam07900 316274011194 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 316274011195 Bacterial transcriptional activator domain; Region: BTAD; smart01043 316274011196 AAA ATPase domain; Region: AAA_16; pfam13191 316274011197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274011198 TPR motif; other site 316274011199 binding surface 316274011200 DinB superfamily; Region: DinB_2; pfam12867 316274011201 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 316274011202 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274011203 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274011204 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274011205 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274011206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274011207 ligand binding site [chemical binding]; other site 316274011208 flexible hinge region; other site 316274011209 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274011210 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274011211 ligand binding site [chemical binding]; other site 316274011212 flexible hinge region; other site 316274011213 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316274011214 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316274011215 Putative esterase; Region: Esterase; pfam00756 316274011216 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 316274011217 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 316274011218 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 316274011219 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316274011220 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 316274011221 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274011222 Cytochrome P450; Region: p450; cl12078 316274011223 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 316274011224 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 316274011225 Sporulation and spore germination; Region: Germane; pfam10646 316274011226 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 316274011227 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 316274011228 active site 316274011229 HIGH motif; other site 316274011230 dimer interface [polypeptide binding]; other site 316274011231 KMSKS motif; other site 316274011232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274011233 RNA binding surface [nucleotide binding]; other site 316274011234 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 316274011235 ligand binding site [chemical binding]; other site 316274011236 active site 316274011237 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 316274011238 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 316274011239 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316274011240 putative RNA binding site [nucleotide binding]; other site 316274011241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011242 S-adenosylmethionine binding site [chemical binding]; other site 316274011243 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 316274011244 active site pocket [active] 316274011245 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316274011246 Protein of unknown function (DUF503); Region: DUF503; pfam04456 316274011247 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 316274011248 homodimer interface [polypeptide binding]; other site 316274011249 maltodextrin glucosidase; Provisional; Region: PRK10785 316274011250 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 316274011251 active site 316274011252 homodimer interface [polypeptide binding]; other site 316274011253 catalytic site [active] 316274011254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274011255 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 316274011256 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 316274011257 UbiA prenyltransferase family; Region: UbiA; pfam01040 316274011258 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011259 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274011260 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274011261 active site 316274011262 dimer interface [polypeptide binding]; other site 316274011263 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 316274011264 Ligand Binding Site [chemical binding]; other site 316274011265 Molecular Tunnel; other site 316274011266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011267 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274011268 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316274011269 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 316274011270 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316274011271 RNA binding site [nucleotide binding]; other site 316274011272 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316274011273 RNA binding site [nucleotide binding]; other site 316274011274 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 316274011275 RNA binding site [nucleotide binding]; other site 316274011276 Family description; Region: VCBS; pfam13517 316274011277 Family description; Region: VCBS; pfam13517 316274011278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274011279 Family description; Region: VCBS; pfam13517 316274011280 Family description; Region: VCBS; pfam13517 316274011281 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 316274011282 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 316274011283 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316274011284 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 316274011285 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316274011286 dimer interface [polypeptide binding]; other site 316274011287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274011288 catalytic residue [active] 316274011289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 316274011290 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274011291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011292 S-adenosylmethionine binding site [chemical binding]; other site 316274011293 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 316274011294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274011295 active site 316274011296 ATP binding site [chemical binding]; other site 316274011297 substrate binding site [chemical binding]; other site 316274011298 activation loop (A-loop); other site 316274011299 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 316274011300 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 316274011301 recombination protein F; Reviewed; Region: recF; PRK00064 316274011302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011303 Walker A/P-loop; other site 316274011304 ATP binding site [chemical binding]; other site 316274011305 Q-loop/lid; other site 316274011306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011307 Q-loop/lid; other site 316274011308 ABC transporter signature motif; other site 316274011309 Walker B; other site 316274011310 D-loop; other site 316274011311 H-loop/switch region; other site 316274011312 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 316274011313 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 316274011314 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 316274011315 Membrane bound O-acyl transferase family; Region: MBOAT_2; pfam13813 316274011316 DinB superfamily; Region: DinB_2; pfam12867 316274011317 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 316274011318 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 316274011319 acyl-activating enzyme (AAE) consensus motif; other site 316274011320 putative AMP binding site [chemical binding]; other site 316274011321 putative active site [active] 316274011322 putative CoA binding site [chemical binding]; other site 316274011323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 316274011324 MOSC domain; Region: MOSC; pfam03473 316274011325 3-alpha domain; Region: 3-alpha; pfam03475 316274011326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011327 Coenzyme A binding pocket [chemical binding]; other site 316274011328 IKI3 family; Region: IKI3; pfam04762 316274011329 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316274011330 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011332 Cytochrome c; Region: Cytochrom_C; pfam00034 316274011333 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 316274011334 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 316274011335 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 316274011336 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 316274011337 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274011338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274011339 non-specific DNA binding site [nucleotide binding]; other site 316274011340 salt bridge; other site 316274011341 sequence-specific DNA binding site [nucleotide binding]; other site 316274011342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274011343 Predicted ATPase [General function prediction only]; Region: COG3903 316274011344 Walker A motif; other site 316274011345 ATP binding site [chemical binding]; other site 316274011346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274011347 binding surface 316274011348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274011349 TPR motif; other site 316274011350 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274011351 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 316274011352 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316274011353 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 316274011354 putative active site [active] 316274011355 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274011356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011357 Walker A/P-loop; other site 316274011358 ATP binding site [chemical binding]; other site 316274011359 Q-loop/lid; other site 316274011360 ABC transporter signature motif; other site 316274011361 Walker B; other site 316274011362 D-loop; other site 316274011363 H-loop/switch region; other site 316274011364 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274011365 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274011366 NADP-binding site; other site 316274011367 homotetramer interface [polypeptide binding]; other site 316274011368 substrate binding site [chemical binding]; other site 316274011369 homodimer interface [polypeptide binding]; other site 316274011370 active site 316274011371 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 316274011372 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316274011373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274011374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274011375 ligand binding site [chemical binding]; other site 316274011376 flexible hinge region; other site 316274011377 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316274011378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011379 Walker A/P-loop; other site 316274011380 ATP binding site [chemical binding]; other site 316274011381 Q-loop/lid; other site 316274011382 ABC transporter signature motif; other site 316274011383 Walker B; other site 316274011384 D-loop; other site 316274011385 H-loop/switch region; other site 316274011386 TOBE domain; Region: TOBE_2; pfam08402 316274011387 Homeodomain-like domain; Region: HTH_23; cl17451 316274011388 Transposase; Region: HTH_Tnp_IS630; pfam01710 316274011389 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 316274011390 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 316274011391 CoA binding domain; Region: CoA_binding_2; pfam13380 316274011392 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 316274011393 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 316274011394 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 316274011395 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 316274011396 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 316274011397 DRTGG domain; Region: DRTGG; pfam07085 316274011398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011399 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316274011400 NAD(P) binding site [chemical binding]; other site 316274011401 active site 316274011402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 316274011403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274011404 DNA binding site [nucleotide binding] 316274011405 active site 316274011406 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 316274011407 Helix-turn-helix domain; Region: HTH_18; pfam12833 316274011408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316274011409 AlkA N-terminal domain; Region: AlkA_N; cl05528 316274011410 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 316274011411 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274011412 minor groove reading motif; other site 316274011413 helix-hairpin-helix signature motif; other site 316274011414 substrate binding pocket [chemical binding]; other site 316274011415 active site 316274011416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 316274011417 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 316274011418 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 316274011419 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 316274011420 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316274011421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274011422 Walker A/P-loop; other site 316274011423 ATP binding site [chemical binding]; other site 316274011424 Q-loop/lid; other site 316274011425 ABC transporter signature motif; other site 316274011426 Walker B; other site 316274011427 D-loop; other site 316274011428 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316274011429 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 316274011430 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 316274011431 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 316274011432 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 316274011433 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 316274011434 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 316274011435 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 316274011436 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 316274011437 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 316274011438 catalytic residues [active] 316274011439 Cytochrome c; Region: Cytochrom_C; cl11414 316274011440 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 316274011441 Phospholipid methyltransferase; Region: PEMT; cl17370 316274011442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274011443 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274011444 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274011445 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274011446 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274011447 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274011448 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316274011449 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316274011450 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 316274011451 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 316274011452 putative active site [active] 316274011453 catalytic triad [active] 316274011454 Protein of unknown function (DUF1444); Region: DUF1444; pfam07285 316274011455 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 316274011456 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 316274011457 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 316274011458 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 316274011459 dimerization interface [polypeptide binding]; other site 316274011460 ATP binding site [chemical binding]; other site 316274011461 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 316274011462 dimerization interface [polypeptide binding]; other site 316274011463 ATP binding site [chemical binding]; other site 316274011464 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 316274011465 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316274011466 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316274011467 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316274011468 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011469 GAF domain; Region: GAF; pfam01590 316274011470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274011471 Histidine kinase; Region: HisKA_3; pfam07730 316274011472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011473 ATP binding site [chemical binding]; other site 316274011474 Mg2+ binding site [ion binding]; other site 316274011475 G-X-G motif; other site 316274011476 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 316274011477 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 316274011478 MOSC domain; Region: MOSC; pfam03473 316274011479 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 316274011480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274011481 catalytic core [active] 316274011482 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316274011483 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274011484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274011485 catalytic residue [active] 316274011486 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 316274011487 Iron-sulfur protein interface; other site 316274011488 proximal heme binding site [chemical binding]; other site 316274011489 L-aspartate oxidase; Provisional; Region: PRK06175 316274011490 FAD binding domain; Region: FAD_binding_2; pfam00890 316274011491 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 316274011492 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 316274011493 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 316274011494 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316274011495 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274011496 NAD(P) binding site [chemical binding]; other site 316274011497 catalytic residues [active] 316274011498 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 316274011499 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 316274011500 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 316274011501 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 316274011502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 316274011503 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 316274011504 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274011505 NAD(P) binding site [chemical binding]; other site 316274011506 catalytic residues [active] 316274011507 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316274011508 NAD(P) binding site [chemical binding]; other site 316274011509 catalytic residues [active] 316274011510 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 316274011511 Ferritin-like domain; Region: Ferritin; pfam00210 316274011512 ferroxidase diiron center [ion binding]; other site 316274011513 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 316274011514 dimer interaction site [polypeptide binding]; other site 316274011515 substrate-binding tunnel; other site 316274011516 active site 316274011517 catalytic site [active] 316274011518 substrate binding site [chemical binding]; other site 316274011519 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316274011520 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 316274011521 acyl-activating enzyme (AAE) consensus motif; other site 316274011522 putative AMP binding site [chemical binding]; other site 316274011523 putative active site [active] 316274011524 putative CoA binding site [chemical binding]; other site 316274011525 hypothetical protein; Validated; Region: PRK06840 316274011526 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 316274011527 active site 316274011528 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 316274011529 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316274011530 TM-ABC transporter signature motif; other site 316274011531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274011532 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274011533 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316274011534 TM-ABC transporter signature motif; other site 316274011535 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 316274011536 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 316274011537 Walker A/P-loop; other site 316274011538 ATP binding site [chemical binding]; other site 316274011539 Q-loop/lid; other site 316274011540 ABC transporter signature motif; other site 316274011541 Walker B; other site 316274011542 D-loop; other site 316274011543 H-loop/switch region; other site 316274011544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274011545 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 316274011546 Walker A/P-loop; other site 316274011547 ATP binding site [chemical binding]; other site 316274011548 Q-loop/lid; other site 316274011549 ABC transporter signature motif; other site 316274011550 Walker B; other site 316274011551 D-loop; other site 316274011552 H-loop/switch region; other site 316274011553 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 316274011554 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 316274011555 putative ligand binding site [chemical binding]; other site 316274011556 Bacterial transcriptional activator domain; Region: BTAD; smart01043 316274011557 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 316274011558 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 316274011559 predicted active site [active] 316274011560 catalytic triad [active] 316274011561 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 316274011562 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 316274011563 active site 316274011564 multimer interface [polypeptide binding]; other site 316274011565 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274011566 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316274011567 Cobalt transport protein; Region: CbiQ; cl00463 316274011568 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 316274011569 C-terminal peptidase (prc); Region: prc; TIGR00225 316274011570 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 316274011571 Domain interface; other site 316274011572 Peptide binding site; other site 316274011573 Active site tetrad [active] 316274011574 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 316274011575 peptidase T-like protein; Region: PepT-like; TIGR01883 316274011576 metal binding site [ion binding]; metal-binding site 316274011577 putative dimer interface [polypeptide binding]; other site 316274011578 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 316274011579 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274011580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316274011581 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 316274011582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274011583 RibD C-terminal domain; Region: RibD_C; cl17279 316274011584 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 316274011585 EamA-like transporter family; Region: EamA; pfam00892 316274011586 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316274011587 EamA-like transporter family; Region: EamA; pfam00892 316274011588 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274011589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011590 S-adenosylmethionine binding site [chemical binding]; other site 316274011591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274011592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011593 S-adenosylmethionine binding site [chemical binding]; other site 316274011594 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274011595 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 316274011596 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316274011597 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011598 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011599 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011600 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 316274011601 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 316274011602 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 316274011603 NAD binding site [chemical binding]; other site 316274011604 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316274011605 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 316274011606 Clp protease; Region: CLP_protease; pfam00574 316274011607 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 316274011608 oligomer interface [polypeptide binding]; other site 316274011609 active site residues [active] 316274011610 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 316274011611 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 316274011612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274011613 Walker A motif; other site 316274011614 ATP binding site [chemical binding]; other site 316274011615 Walker B motif; other site 316274011616 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316274011617 short chain dehydrogenase; Provisional; Region: PRK06197 316274011618 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 316274011619 putative NAD(P) binding site [chemical binding]; other site 316274011620 active site 316274011621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274011622 Protein of unknown function (DUF554); Region: DUF554; pfam04474 316274011623 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274011624 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274011625 DNA binding residues [nucleotide binding] 316274011626 drug binding residues [chemical binding]; other site 316274011627 dimer interface [polypeptide binding]; other site 316274011628 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 316274011629 histidyl-tRNA synthetase; Region: hisS; TIGR00442 316274011630 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 316274011631 dimer interface [polypeptide binding]; other site 316274011632 motif 1; other site 316274011633 motif 2; other site 316274011634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274011635 active site 316274011636 motif 3; other site 316274011637 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 316274011638 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 316274011639 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 316274011640 dimer interface [polypeptide binding]; other site 316274011641 motif 1; other site 316274011642 active site 316274011643 motif 2; other site 316274011644 motif 3; other site 316274011645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274011646 dimerization interface [polypeptide binding]; other site 316274011647 putative DNA binding site [nucleotide binding]; other site 316274011648 putative Zn2+ binding site [ion binding]; other site 316274011649 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 316274011650 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011651 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011652 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274011653 YGGT family; Region: YGGT; pfam02325 316274011654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011655 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274011656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274011657 S-adenosylmethionine binding site [chemical binding]; other site 316274011658 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274011659 catalytic core [active] 316274011660 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 316274011661 cofactor binding site; other site 316274011662 metal binding site [ion binding]; metal-binding site 316274011663 NB-ARC domain; Region: NB-ARC; pfam00931 316274011664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274011665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274011666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274011667 binding surface 316274011668 TPR motif; other site 316274011669 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 316274011670 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 316274011671 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274011672 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 316274011673 Phosphotransferase enzyme family; Region: APH; pfam01636 316274011674 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274011675 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 316274011676 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 316274011677 active site 316274011678 PHP Thumb interface [polypeptide binding]; other site 316274011679 metal binding site [ion binding]; metal-binding site 316274011680 Head binding; Region: Head_binding; pfam09008 316274011681 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 316274011682 generic binding surface II; other site 316274011683 generic binding surface I; other site 316274011684 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 316274011685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274011686 DNA binding residues [nucleotide binding] 316274011687 CsbD-like; Region: CsbD; pfam05532 316274011688 CsbD-like; Region: CsbD; pfam05532 316274011689 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 316274011690 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011691 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274011692 NHL repeat; Region: NHL; pfam01436 316274011693 NHL repeat; Region: NHL; pfam01436 316274011694 NHL repeat; Region: NHL; pfam01436 316274011695 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274011696 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 316274011697 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316274011698 NAD binding site [chemical binding]; other site 316274011699 catalytic residues [active] 316274011700 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 316274011701 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274011702 active site 316274011703 catalytic site [active] 316274011704 hypothetical protein; Provisional; Region: PRK04262 316274011705 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 316274011706 dimer interface [polypeptide binding]; other site 316274011707 active site 316274011708 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 316274011709 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 316274011710 active site 316274011711 DUF35 OB-fold domain; Region: DUF35; pfam01796 316274011712 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 316274011713 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 316274011714 putative trimer interface [polypeptide binding]; other site 316274011715 putative CoA binding site [chemical binding]; other site 316274011716 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316274011717 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 316274011718 hydrophobic ligand binding site; other site 316274011719 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 316274011720 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 316274011721 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 316274011722 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316274011723 Predicted membrane protein [Function unknown]; Region: COG1238 316274011724 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 316274011725 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 316274011726 DTAP/Switch II; other site 316274011727 Switch I; other site 316274011728 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 316274011729 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 316274011730 RNase E interface [polypeptide binding]; other site 316274011731 trimer interface [polypeptide binding]; other site 316274011732 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 316274011733 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 316274011734 RNase E interface [polypeptide binding]; other site 316274011735 trimer interface [polypeptide binding]; other site 316274011736 active site 316274011737 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 316274011738 putative nucleic acid binding region [nucleotide binding]; other site 316274011739 G-X-X-G motif; other site 316274011740 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 316274011741 RNA binding site [nucleotide binding]; other site 316274011742 domain interface; other site 316274011743 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 316274011744 16S/18S rRNA binding site [nucleotide binding]; other site 316274011745 S13e-L30e interaction site [polypeptide binding]; other site 316274011746 25S rRNA binding site [nucleotide binding]; other site 316274011747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274011748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274011749 Coenzyme A binding pocket [chemical binding]; other site 316274011750 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 316274011751 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 316274011752 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 316274011753 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 316274011754 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 316274011755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274011756 catalytic residue [active] 316274011757 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 316274011758 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316274011759 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 316274011760 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 316274011761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274011762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274011763 alpha-galactosidase; Region: PLN02808; cl17638 316274011764 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 316274011765 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274011766 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 316274011767 putative NAD(P) binding site [chemical binding]; other site 316274011768 Predicted transcriptional regulators [Transcription]; Region: COG1733 316274011769 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 316274011770 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316274011771 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274011772 intersubunit interface [polypeptide binding]; other site 316274011773 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274011774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274011775 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274011776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011777 NAD(P) binding site [chemical binding]; other site 316274011778 active site 316274011779 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274011780 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274011781 Ligand binding site; other site 316274011782 Putative Catalytic site; other site 316274011783 DXD motif; other site 316274011784 Predicted membrane protein [Function unknown]; Region: COG2261 316274011785 Predicted membrane protein [Function unknown]; Region: COG2261 316274011786 aminotransferase; Validated; Region: PRK07777 316274011787 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274011788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274011789 homodimer interface [polypeptide binding]; other site 316274011790 catalytic residue [active] 316274011791 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316274011792 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 316274011793 NADP binding site [chemical binding]; other site 316274011794 dimer interface [polypeptide binding]; other site 316274011795 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 316274011796 GAF domain; Region: GAF_3; pfam13492 316274011797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011798 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274011799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274011800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274011801 dimer interface [polypeptide binding]; other site 316274011802 phosphorylation site [posttranslational modification] 316274011803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011804 ATP binding site [chemical binding]; other site 316274011805 Mg2+ binding site [ion binding]; other site 316274011806 G-X-G motif; other site 316274011807 Response regulator receiver domain; Region: Response_reg; pfam00072 316274011808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274011809 active site 316274011810 phosphorylation site [posttranslational modification] 316274011811 intermolecular recognition site; other site 316274011812 dimerization interface [polypeptide binding]; other site 316274011813 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 316274011814 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 316274011815 Chromate transporter; Region: Chromate_transp; pfam02417 316274011816 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274011817 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274011818 rhodanese superfamily protein; Provisional; Region: PRK05320 316274011819 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 316274011820 active site residue [active] 316274011821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011822 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 316274011823 NAD(P) binding site [chemical binding]; other site 316274011824 active site 316274011825 HD domain; Region: HD_4; pfam13328 316274011826 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 316274011827 Predicted methyltransferases [General function prediction only]; Region: COG0313 316274011828 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 316274011829 putative SAM binding site [chemical binding]; other site 316274011830 putative homodimer interface [polypeptide binding]; other site 316274011831 Small T antigen; Reviewed; Region: PHA03102 316274011832 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 316274011833 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 316274011834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274011835 Walker A motif; other site 316274011836 ATP binding site [chemical binding]; other site 316274011837 Walker B motif; other site 316274011838 arginine finger; other site 316274011839 hypothetical protein; Validated; Region: PRK00153 316274011840 recombination protein RecR; Reviewed; Region: recR; PRK00076 316274011841 RecR protein; Region: RecR; pfam02132 316274011842 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 316274011843 putative active site [active] 316274011844 putative metal-binding site [ion binding]; other site 316274011845 tetramer interface [polypeptide binding]; other site 316274011846 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316274011847 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274011848 metal ion-dependent adhesion site (MIDAS); other site 316274011849 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274011850 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274011851 metal ion-dependent adhesion site (MIDAS); other site 316274011852 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274011853 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 316274011854 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 316274011855 ApbE family; Region: ApbE; pfam02424 316274011856 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 316274011857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274011858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274011859 active site 316274011860 phosphorylation site [posttranslational modification] 316274011861 intermolecular recognition site; other site 316274011862 dimerization interface [polypeptide binding]; other site 316274011863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274011864 DNA binding site [nucleotide binding] 316274011865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274011866 dimer interface [polypeptide binding]; other site 316274011867 phosphorylation site [posttranslational modification] 316274011868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011869 ATP binding site [chemical binding]; other site 316274011870 Mg2+ binding site [ion binding]; other site 316274011871 G-X-G motif; other site 316274011872 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 316274011873 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 316274011874 DinB family; Region: DinB; cl17821 316274011875 DinB superfamily; Region: DinB_2; pfam12867 316274011876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274011877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274011878 putative substrate translocation pore; other site 316274011879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274011880 GAF domain; Region: GAF; pfam01590 316274011881 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274011882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274011883 dimer interface [polypeptide binding]; other site 316274011884 phosphorylation site [posttranslational modification] 316274011885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274011886 ATP binding site [chemical binding]; other site 316274011887 Mg2+ binding site [ion binding]; other site 316274011888 G-X-G motif; other site 316274011889 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274011890 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274011891 nucleotide binding site [chemical binding]; other site 316274011892 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274011893 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274011894 metal ion-dependent adhesion site (MIDAS); other site 316274011895 TadE-like protein; Region: TadE; pfam07811 316274011896 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 316274011897 TadE-like protein; Region: TadE; pfam07811 316274011898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274011899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274011900 active site 316274011901 ATP binding site [chemical binding]; other site 316274011902 substrate binding site [chemical binding]; other site 316274011903 activation loop (A-loop); other site 316274011904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274011905 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274011906 active site 316274011907 ATP binding site [chemical binding]; other site 316274011908 substrate binding site [chemical binding]; other site 316274011909 activation loop (A-loop); other site 316274011910 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 316274011911 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 316274011912 glutaminase active site [active] 316274011913 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316274011914 dimer interface [polypeptide binding]; other site 316274011915 active site 316274011916 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316274011917 dimer interface [polypeptide binding]; other site 316274011918 active site 316274011919 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 316274011920 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 316274011921 AAA domain; Region: AAA_22; pfam13401 316274011922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274011923 Walker B motif; other site 316274011924 TniQ; Region: TniQ; pfam06527 316274011925 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274011926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274011927 sequence-specific DNA binding site [nucleotide binding]; other site 316274011928 salt bridge; other site 316274011929 Chorismate lyase; Region: Chor_lyase; cl01230 316274011930 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274011931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316274011932 acyl-activating enzyme (AAE) consensus motif; other site 316274011933 AMP binding site [chemical binding]; other site 316274011934 active site 316274011935 CoA binding site [chemical binding]; other site 316274011936 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274011937 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274011938 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011939 active site 316274011940 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011941 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 316274011942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011943 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 316274011944 Enoylreductase; Region: PKS_ER; smart00829 316274011945 NAD(P) binding site [chemical binding]; other site 316274011946 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274011947 KR domain; Region: KR; pfam08659 316274011948 putative NADP binding site [chemical binding]; other site 316274011949 active site 316274011950 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274011951 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274011952 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011953 active site 316274011954 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011955 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 316274011956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274011957 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316274011958 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 316274011959 Enoylreductase; Region: PKS_ER; smart00829 316274011960 NAD(P) binding site [chemical binding]; other site 316274011961 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 316274011962 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274011963 putative NADP binding site [chemical binding]; other site 316274011964 active site 316274011965 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 316274011966 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274011967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011968 active site 316274011969 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011970 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274011971 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274011972 putative NADP binding site [chemical binding]; other site 316274011973 active site 316274011974 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274011975 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011976 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274011977 active site 316274011978 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274011979 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011980 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274011981 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274011982 putative NADP binding site [chemical binding]; other site 316274011983 active site 316274011984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274011985 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274011986 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011987 active site 316274011988 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274011989 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011990 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274011991 putative NADP binding site [chemical binding]; other site 316274011992 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274011993 active site 316274011994 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274011995 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274011996 active site 316274011997 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274011998 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274011999 putative NADP binding site [chemical binding]; other site 316274012000 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012001 active site 316274012002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012003 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012004 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012005 active site 316274012006 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012007 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012008 putative NADP binding site [chemical binding]; other site 316274012009 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012010 active site 316274012011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012012 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012013 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012014 active site 316274012015 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274012017 NAD(P) binding site [chemical binding]; other site 316274012018 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012019 active site 316274012020 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012021 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012022 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012023 active site 316274012024 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012025 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012026 putative NADP binding site [chemical binding]; other site 316274012027 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012028 active site 316274012029 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012030 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012031 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012032 active site 316274012033 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012034 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012035 putative NADP binding site [chemical binding]; other site 316274012036 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012037 active site 316274012038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012039 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012040 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316274012041 active site 316274012042 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316274012043 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274012045 NAD(P) binding site [chemical binding]; other site 316274012046 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012047 active site 316274012048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012049 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012050 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012051 active site 316274012052 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012053 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012054 putative NADP binding site [chemical binding]; other site 316274012055 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012056 active site 316274012057 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012058 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012059 active site 316274012060 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012061 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012062 putative NADP binding site [chemical binding]; other site 316274012063 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012064 active site 316274012065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012066 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012067 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012068 active site 316274012069 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012070 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012071 putative NADP binding site [chemical binding]; other site 316274012072 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012073 active site 316274012074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012075 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012076 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012077 active site 316274012078 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012079 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012080 putative NADP binding site [chemical binding]; other site 316274012081 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012082 active site 316274012083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012084 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316274012085 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316274012086 active site 316274012087 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 316274012088 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316274012089 putative NADP binding site [chemical binding]; other site 316274012090 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 316274012091 active site 316274012092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012093 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 316274012094 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316274012095 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274012096 acyl carrier protein; Provisional; Region: PRK07081 316274012097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274012098 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274012099 active site 316274012100 FkbH-like domain; Region: FkbH; TIGR01686 316274012101 Acid Phosphatase; Region: Acid_PPase; cl17256 316274012102 Condensation domain; Region: Condensation; pfam00668 316274012103 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274012104 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012105 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274012106 acyl-activating enzyme (AAE) consensus motif; other site 316274012107 AMP binding site [chemical binding]; other site 316274012108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274012110 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 316274012111 acyl-activating enzyme (AAE) consensus motif; other site 316274012112 AMP binding site [chemical binding]; other site 316274012113 peptide synthase; Validated; Region: PRK05691 316274012114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012115 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012116 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 316274012117 acyl-activating enzyme (AAE) consensus motif; other site 316274012118 AMP binding site [chemical binding]; other site 316274012119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012120 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012121 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 316274012122 acyl-activating enzyme (AAE) consensus motif; other site 316274012123 AMP binding site [chemical binding]; other site 316274012124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012126 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012127 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 316274012128 acyl-activating enzyme (AAE) consensus motif; other site 316274012129 AMP binding site [chemical binding]; other site 316274012130 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012131 Condensation domain; Region: Condensation; pfam00668 316274012132 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 316274012133 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012134 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274012135 acyl-activating enzyme (AAE) consensus motif; other site 316274012136 AMP binding site [chemical binding]; other site 316274012137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012138 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 316274012139 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 316274012140 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 316274012141 acyl-activating enzyme (AAE) consensus motif; other site 316274012142 AMP binding site [chemical binding]; other site 316274012143 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316274012144 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 316274012145 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 316274012146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274012147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274012148 Walker A/P-loop; other site 316274012149 ATP binding site [chemical binding]; other site 316274012150 Q-loop/lid; other site 316274012151 ABC transporter signature motif; other site 316274012152 Walker B; other site 316274012153 D-loop; other site 316274012154 H-loop/switch region; other site 316274012155 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274012156 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316274012157 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 316274012158 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316274012159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 316274012160 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 316274012161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274012162 S-adenosylmethionine binding site [chemical binding]; other site 316274012163 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 316274012164 classical (c) SDRs; Region: SDR_c; cd05233 316274012165 NAD(P) binding site [chemical binding]; other site 316274012166 active site 316274012167 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316274012168 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 316274012169 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 316274012170 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 316274012171 Cna protein B-type domain; Region: Cna_B; pfam05738 316274012172 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 316274012173 B12 binding site [chemical binding]; other site 316274012174 cobalt ligand [ion binding]; other site 316274012175 LAO/AO transport system ATPase; Region: lao; TIGR00750 316274012176 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 316274012177 Walker A; other site 316274012178 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 316274012179 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 316274012180 Ligand binding site; other site 316274012181 Ligand binding site; other site 316274012182 Ligand binding site; other site 316274012183 Putative Catalytic site; other site 316274012184 DXD motif; other site 316274012185 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 316274012186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274012187 active site 316274012188 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 316274012189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274012190 Walker A motif; other site 316274012191 ATP binding site [chemical binding]; other site 316274012192 Walker B motif; other site 316274012193 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316274012194 peptide chain release factor 2; Region: prfB; TIGR00020 316274012195 PCRF domain; Region: PCRF; cl17745 316274012196 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 316274012197 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316274012198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316274012199 Clostripain family; Region: Peptidase_C11; pfam03415 316274012200 CARDB; Region: CARDB; pfam07705 316274012201 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274012202 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012203 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012205 binding surface 316274012206 TPR motif; other site 316274012207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012208 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 316274012209 PBP superfamily domain; Region: PBP_like_2; cl17296 316274012210 PBP superfamily domain; Region: PBP_like_2; cl17296 316274012211 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 316274012212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274012213 dimer interface [polypeptide binding]; other site 316274012214 conserved gate region; other site 316274012215 putative PBP binding loops; other site 316274012216 ABC-ATPase subunit interface; other site 316274012217 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 316274012218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274012219 dimer interface [polypeptide binding]; other site 316274012220 conserved gate region; other site 316274012221 putative PBP binding loops; other site 316274012222 ABC-ATPase subunit interface; other site 316274012223 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 316274012224 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 316274012225 Walker A/P-loop; other site 316274012226 ATP binding site [chemical binding]; other site 316274012227 Q-loop/lid; other site 316274012228 ABC transporter signature motif; other site 316274012229 Walker B; other site 316274012230 D-loop; other site 316274012231 H-loop/switch region; other site 316274012232 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316274012233 PhoU domain; Region: PhoU; pfam01895 316274012234 PhoU domain; Region: PhoU; pfam01895 316274012235 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 316274012236 active site 316274012237 catalytic residues [active] 316274012238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 316274012239 Putative esterase; Region: Esterase; pfam00756 316274012240 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 316274012241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012242 putative ADP-binding pocket [chemical binding]; other site 316274012243 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 316274012244 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316274012245 active site 316274012246 dimer interface [polypeptide binding]; other site 316274012247 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 316274012248 Ligand Binding Site [chemical binding]; other site 316274012249 Molecular Tunnel; other site 316274012250 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 316274012251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274012252 Chain length determinant protein; Region: Wzz; cl15801 316274012253 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 316274012254 Chain length determinant protein; Region: Wzz; cl15801 316274012255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012256 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 316274012257 putative ADP-binding pocket [chemical binding]; other site 316274012258 YCII-related domain; Region: YCII; cl00999 316274012259 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274012260 active site 316274012261 metal binding site [ion binding]; metal-binding site 316274012262 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 316274012263 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 316274012264 hypothetical protein; Provisional; Region: PRK08609 316274012265 active site 316274012266 primer binding site [nucleotide binding]; other site 316274012267 NTP binding site [chemical binding]; other site 316274012268 metal binding triad [ion binding]; metal-binding site 316274012269 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 316274012270 active site 316274012271 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 316274012272 HIT family signature motif; other site 316274012273 catalytic residue [active] 316274012274 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 316274012275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316274012276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316274012277 catalytic residue [active] 316274012278 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 316274012279 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 316274012280 MOFRL family; Region: MOFRL; pfam05161 316274012281 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274012282 peptide binding site [polypeptide binding]; other site 316274012283 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274012284 dimer interface [polypeptide binding]; other site 316274012285 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316274012286 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316274012287 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 316274012288 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 316274012289 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 316274012290 active site 316274012291 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316274012292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012293 binding surface 316274012294 TPR motif; other site 316274012295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012296 binding surface 316274012297 TPR motif; other site 316274012298 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 316274012299 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316274012300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316274012301 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 316274012302 Uncharacterized conserved protein [Function unknown]; Region: COG1479 316274012303 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274012304 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274012305 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 316274012306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274012307 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274012308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274012309 Bacterial SH3 domain; Region: SH3_4; pfam06347 316274012310 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274012311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274012312 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274012313 ABC-ATPase subunit interface; other site 316274012314 dimer interface [polypeptide binding]; other site 316274012315 putative PBP binding regions; other site 316274012316 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316274012317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316274012318 ABC-ATPase subunit interface; other site 316274012319 dimer interface [polypeptide binding]; other site 316274012320 putative PBP binding regions; other site 316274012321 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316274012322 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316274012323 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 316274012324 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316274012325 intersubunit interface [polypeptide binding]; other site 316274012326 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 316274012327 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 316274012328 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 316274012329 FeoA domain; Region: FeoA; pfam04023 316274012330 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 316274012331 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316274012332 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316274012333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274012334 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274012335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274012336 dimer interface [polypeptide binding]; other site 316274012337 conserved gate region; other site 316274012338 putative PBP binding loops; other site 316274012339 ABC-ATPase subunit interface; other site 316274012340 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274012341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274012342 dimer interface [polypeptide binding]; other site 316274012343 conserved gate region; other site 316274012344 putative PBP binding loops; other site 316274012345 ABC-ATPase subunit interface; other site 316274012346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274012347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012348 active site 316274012349 phosphorylation site [posttranslational modification] 316274012350 intermolecular recognition site; other site 316274012351 dimerization interface [polypeptide binding]; other site 316274012352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274012353 DNA binding site [nucleotide binding] 316274012354 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 316274012355 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 316274012356 oligomer interface [polypeptide binding]; other site 316274012357 metal binding site [ion binding]; metal-binding site 316274012358 metal binding site [ion binding]; metal-binding site 316274012359 putative Cl binding site [ion binding]; other site 316274012360 aspartate ring; other site 316274012361 basic sphincter; other site 316274012362 hydrophobic gate; other site 316274012363 periplasmic entrance; other site 316274012364 translocation protein TolB; Provisional; Region: tolB; PRK01742 316274012365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274012366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012367 active site 316274012368 phosphorylation site [posttranslational modification] 316274012369 intermolecular recognition site; other site 316274012370 dimerization interface [polypeptide binding]; other site 316274012371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274012372 DNA binding residues [nucleotide binding] 316274012373 dimerization interface [polypeptide binding]; other site 316274012374 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 316274012375 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274012376 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274012377 active site 316274012378 ATP binding site [chemical binding]; other site 316274012379 substrate binding site [chemical binding]; other site 316274012380 activation loop (A-loop); other site 316274012381 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 316274012382 Trp docking motif [polypeptide binding]; other site 316274012383 active site 316274012384 PQQ-like domain; Region: PQQ_2; pfam13360 316274012385 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274012386 Protein phosphatase 2C; Region: PP2C; pfam00481 316274012387 active site 316274012388 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274012389 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274012390 metal ion-dependent adhesion site (MIDAS); other site 316274012391 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274012392 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274012393 phosphopeptide binding site; other site 316274012394 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 316274012395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274012396 non-specific DNA binding site [nucleotide binding]; other site 316274012397 salt bridge; other site 316274012398 sequence-specific DNA binding site [nucleotide binding]; other site 316274012399 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 316274012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 316274012401 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 316274012402 putative oxidoreductase; Provisional; Region: PRK11579 316274012403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316274012404 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 316274012405 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 316274012406 Uncharacterized conserved protein [Function unknown]; Region: COG4021 316274012407 Thg1 C terminal domain; Region: Thg1C; pfam14413 316274012408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 316274012409 AAA domain; Region: AAA_33; pfam13671 316274012410 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274012411 Leucine-rich repeats; other site 316274012412 Substrate binding site [chemical binding]; other site 316274012413 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 316274012414 Leucine-rich repeats; other site 316274012415 Substrate binding site [chemical binding]; other site 316274012416 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 316274012417 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 316274012418 active site 316274012419 nucleophile elbow; other site 316274012420 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 316274012421 catalytic center binding site [active] 316274012422 ATP binding site [chemical binding]; other site 316274012423 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316274012424 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274012425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012426 active site 316274012427 phosphorylation site [posttranslational modification] 316274012428 intermolecular recognition site; other site 316274012429 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274012430 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274012431 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274012432 PhoD-like phosphatase; Region: PhoD; pfam09423 316274012433 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 316274012434 putative active site [active] 316274012435 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274012436 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012437 TPR repeat; Region: TPR_11; pfam13414 316274012438 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274012439 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 316274012440 VanW like protein; Region: VanW; pfam04294 316274012441 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274012442 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316274012443 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012444 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012445 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 316274012446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274012447 dimer interface [polypeptide binding]; other site 316274012448 phosphorylation site [posttranslational modification] 316274012449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012450 ATP binding site [chemical binding]; other site 316274012451 Mg2+ binding site [ion binding]; other site 316274012452 G-X-G motif; other site 316274012453 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 316274012454 putative active site [active] 316274012455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 316274012456 salt bridge; other site 316274012457 non-specific DNA binding site [nucleotide binding]; other site 316274012458 sequence-specific DNA binding site [nucleotide binding]; other site 316274012459 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 316274012460 DNA methylase; Region: N6_N4_Mtase; pfam01555 316274012461 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 316274012462 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316274012463 active site 316274012464 Ca binding site [ion binding]; other site 316274012465 catalytic site [active] 316274012466 Aamy_C domain; Region: Aamy_C; smart00632 316274012467 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 316274012468 starch-binding site 2 [chemical binding]; other site 316274012469 starch-binding site 1 [chemical binding]; other site 316274012470 ATP synthase A chain; Region: ATP-synt_A; cl00413 316274012471 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 316274012472 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 316274012473 F0F1 ATP synthase subunit B; Provisional; Region: PRK14473 316274012474 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 316274012475 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 316274012476 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 316274012477 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 316274012478 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316274012479 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 316274012480 beta subunit interaction interface [polypeptide binding]; other site 316274012481 Walker A motif; other site 316274012482 ATP binding site [chemical binding]; other site 316274012483 Walker B motif; other site 316274012484 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316274012485 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 316274012486 core domain interface [polypeptide binding]; other site 316274012487 delta subunit interface [polypeptide binding]; other site 316274012488 epsilon subunit interface [polypeptide binding]; other site 316274012489 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 316274012490 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316274012491 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 316274012492 alpha subunit interaction interface [polypeptide binding]; other site 316274012493 Walker A motif; other site 316274012494 ATP binding site [chemical binding]; other site 316274012495 Walker B motif; other site 316274012496 inhibitor binding site; inhibition site 316274012497 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316274012498 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 316274012499 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 316274012500 gamma subunit interface [polypeptide binding]; other site 316274012501 epsilon subunit interface [polypeptide binding]; other site 316274012502 LBP interface [polypeptide binding]; other site 316274012503 rod shape-determining protein MreB; Provisional; Region: PRK13930 316274012504 MreB and similar proteins; Region: MreB_like; cd10225 316274012505 nucleotide binding site [chemical binding]; other site 316274012506 Mg binding site [ion binding]; other site 316274012507 putative protofilament interaction site [polypeptide binding]; other site 316274012508 RodZ interaction site [polypeptide binding]; other site 316274012509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274012510 Zn2+ binding site [ion binding]; other site 316274012511 Mg2+ binding site [ion binding]; other site 316274012512 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 316274012513 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 316274012514 active site 316274012515 substrate-binding site [chemical binding]; other site 316274012516 metal-binding site [ion binding] 316274012517 ATP binding site [chemical binding]; other site 316274012518 CHAT domain; Region: CHAT; cl17868 316274012519 AAA domain; Region: AAA_22; pfam13401 316274012520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012521 TPR motif; other site 316274012522 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012523 binding surface 316274012524 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274012526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012527 binding surface 316274012528 TPR motif; other site 316274012529 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 316274012530 MutS domain I; Region: MutS_I; pfam01624 316274012531 MutS domain II; Region: MutS_II; pfam05188 316274012532 MutS domain III; Region: MutS_III; pfam05192 316274012533 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 316274012534 Walker A/P-loop; other site 316274012535 ATP binding site [chemical binding]; other site 316274012536 Q-loop/lid; other site 316274012537 ABC transporter signature motif; other site 316274012538 Walker B; other site 316274012539 D-loop; other site 316274012540 H-loop/switch region; other site 316274012541 prephenate dehydrogenase; Validated; Region: PRK08507 316274012542 Prephenate dehydrogenase; Region: PDH; pfam02153 316274012543 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 316274012544 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 316274012545 Tetramer interface [polypeptide binding]; other site 316274012546 active site 316274012547 FMN-binding site [chemical binding]; other site 316274012548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274012549 TPR motif; other site 316274012550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012551 TPR motif; other site 316274012552 TPR repeat; Region: TPR_11; pfam13414 316274012553 binding surface 316274012554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274012555 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274012556 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 316274012557 dimer interface [polypeptide binding]; other site 316274012558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316274012559 ligand binding site [chemical binding]; other site 316274012560 NAD-dependent deacetylase; Provisional; Region: PRK00481 316274012561 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 316274012562 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274012563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316274012564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316274012565 protein binding site [polypeptide binding]; other site 316274012566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274012567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274012568 DNA binding residues [nucleotide binding] 316274012569 dimerization interface [polypeptide binding]; other site 316274012570 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 316274012571 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 316274012572 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316274012573 anti sigma factor interaction site; other site 316274012574 regulatory phosphorylation site [posttranslational modification]; other site 316274012575 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 316274012576 competence damage-inducible protein A; Provisional; Region: PRK00549 316274012577 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 316274012578 putative MPT binding site; other site 316274012579 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 316274012580 dihydroorotase; Validated; Region: pyrC; PRK09357 316274012581 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316274012582 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 316274012583 active site 316274012584 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 316274012585 6-phosphofructokinase; Provisional; Region: PRK03202 316274012586 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 316274012587 active site 316274012588 ADP/pyrophosphate binding site [chemical binding]; other site 316274012589 dimerization interface [polypeptide binding]; other site 316274012590 allosteric effector site; other site 316274012591 fructose-1,6-bisphosphate binding site; other site 316274012592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274012593 primosomal protein N' Region: priA; TIGR00595 316274012594 ATP binding site [chemical binding]; other site 316274012595 putative Mg++ binding site [ion binding]; other site 316274012596 aconitate hydratase; Validated; Region: PRK09277 316274012597 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 316274012598 substrate binding site [chemical binding]; other site 316274012599 ligand binding site [chemical binding]; other site 316274012600 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 316274012601 substrate binding site [chemical binding]; other site 316274012602 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316274012603 cyclase homology domain; Region: CHD; cd07302 316274012604 nucleotidyl binding site; other site 316274012605 metal binding site [ion binding]; metal-binding site 316274012606 dimer interface [polypeptide binding]; other site 316274012607 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 316274012608 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316274012609 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274012610 dimer interface [polypeptide binding]; other site 316274012611 ssDNA binding site [nucleotide binding]; other site 316274012612 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274012613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274012614 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274012615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012616 active site 316274012617 phosphorylation site [posttranslational modification] 316274012618 intermolecular recognition site; other site 316274012619 dimerization interface [polypeptide binding]; other site 316274012620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012621 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012622 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012623 GAF domain; Region: GAF; pfam01590 316274012624 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012625 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012626 GAF domain; Region: GAF_2; pfam13185 316274012627 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012628 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012629 GAF domain; Region: GAF_3; pfam13492 316274012630 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012633 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012634 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012635 GAF domain; Region: GAF; pfam01590 316274012636 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012637 GAF domain; Region: GAF_3; pfam13492 316274012638 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012639 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012640 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012641 GAF domain; Region: GAF; pfam01590 316274012642 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012643 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012644 GAF domain; Region: GAF_2; pfam13185 316274012645 GAF domain; Region: GAF; pfam01590 316274012646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274012647 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012648 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012649 GAF domain; Region: GAF_2; pfam13185 316274012650 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274012651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274012652 putative active site [active] 316274012653 heme pocket [chemical binding]; other site 316274012654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274012655 dimer interface [polypeptide binding]; other site 316274012656 phosphorylation site [posttranslational modification] 316274012657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274012658 ATP binding site [chemical binding]; other site 316274012659 Mg2+ binding site [ion binding]; other site 316274012660 G-X-G motif; other site 316274012661 Response regulator receiver domain; Region: Response_reg; pfam00072 316274012662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012663 active site 316274012664 phosphorylation site [posttranslational modification] 316274012665 intermolecular recognition site; other site 316274012666 dimerization interface [polypeptide binding]; other site 316274012667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274012668 metal binding site [ion binding]; metal-binding site 316274012669 active site 316274012670 I-site; other site 316274012671 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274012672 putative trimer interface [polypeptide binding]; other site 316274012673 putative CoA binding site [chemical binding]; other site 316274012674 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316274012675 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316274012676 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316274012677 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 316274012678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274012679 Cytochrome P450; Region: p450; cl12078 316274012680 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316274012681 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 316274012682 active site 316274012683 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 316274012684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274012685 FeS/SAM binding site; other site 316274012686 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316274012687 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 316274012688 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 316274012689 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316274012690 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 316274012691 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 316274012692 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316274012693 active site 316274012694 HIGH motif; other site 316274012695 KMSK motif region; other site 316274012696 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316274012697 tRNA binding surface [nucleotide binding]; other site 316274012698 anticodon binding site; other site 316274012699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274012700 S-adenosylmethionine binding site [chemical binding]; other site 316274012701 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 316274012702 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316274012703 active site 316274012704 HIGH motif; other site 316274012705 KMSK motif region; other site 316274012706 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316274012707 tRNA binding surface [nucleotide binding]; other site 316274012708 anticodon binding site; other site 316274012709 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 316274012710 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274012711 ornithine carbamoyltransferase; Provisional; Region: PRK00779 316274012712 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316274012713 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316274012714 argininosuccinate lyase; Provisional; Region: PRK00855 316274012715 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 316274012716 active sites [active] 316274012717 tetramer interface [polypeptide binding]; other site 316274012718 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 316274012719 heterotetramer interface [polypeptide binding]; other site 316274012720 active site pocket [active] 316274012721 cleavage site 316274012722 argininosuccinate synthase; Provisional; Region: PRK13820 316274012723 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 316274012724 ANP binding site [chemical binding]; other site 316274012725 Substrate Binding Site II [chemical binding]; other site 316274012726 Substrate Binding Site I [chemical binding]; other site 316274012727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274012728 Coenzyme A binding pocket [chemical binding]; other site 316274012729 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274012730 nudix motif; other site 316274012731 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 316274012732 nucleotide binding site [chemical binding]; other site 316274012733 N-acetyl-L-glutamate binding site [chemical binding]; other site 316274012734 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316274012735 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316274012736 Helix-turn-helix domain; Region: HTH_17; pfam12728 316274012737 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 316274012738 dimer interface [polypeptide binding]; other site 316274012739 active site 316274012740 coenzyme A binding site [chemical binding]; other site 316274012741 citrylCoA binding site [chemical binding]; other site 316274012742 Citrate synthase; Region: Citrate_synt; pfam00285 316274012743 oxalacetate/citrate binding site [chemical binding]; other site 316274012744 catalytic triad [active] 316274012745 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 316274012746 dimer interface [polypeptide binding]; other site 316274012747 Citrate synthase; Region: Citrate_synt; pfam00285 316274012748 active site 316274012749 citrylCoA binding site [chemical binding]; other site 316274012750 oxalacetate/citrate binding site [chemical binding]; other site 316274012751 coenzyme A binding site [chemical binding]; other site 316274012752 catalytic triad [active] 316274012753 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274012754 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274012755 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274012756 substrate binding pocket [chemical binding]; other site 316274012757 substrate-Mg2+ binding site; other site 316274012758 aspartate-rich region 1; other site 316274012759 aspartate-rich region 2; other site 316274012760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274012761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274012762 Coenzyme A binding pocket [chemical binding]; other site 316274012763 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316274012764 EamA-like transporter family; Region: EamA; pfam00892 316274012765 EamA-like transporter family; Region: EamA; pfam00892 316274012766 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 316274012767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274012768 motif II; other site 316274012769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274012770 dimerization interface [polypeptide binding]; other site 316274012771 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012772 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 316274012773 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 316274012774 putative ligand binding site [chemical binding]; other site 316274012775 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 316274012776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274012777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012778 active site 316274012779 phosphorylation site [posttranslational modification] 316274012780 intermolecular recognition site; other site 316274012781 dimerization interface [polypeptide binding]; other site 316274012782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274012783 DNA binding site [nucleotide binding] 316274012784 High-affinity nickel-transport protein; Region: NicO; cl00964 316274012785 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 316274012786 Low molecular weight phosphatase family; Region: LMWPc; cl00105 316274012787 active site 316274012788 Protein of unknown function (DUF524); Region: DUF524; pfam04411 316274012789 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 316274012790 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 316274012791 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 316274012792 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316274012793 P loop; other site 316274012794 GTP binding site [chemical binding]; other site 316274012795 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 316274012796 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 316274012797 substrate binding site; other site 316274012798 metal-binding site 316274012799 Oligomer interface; other site 316274012800 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274012801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012802 binding surface 316274012803 TPR motif; other site 316274012804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012805 binding surface 316274012806 TPR motif; other site 316274012807 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316274012808 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316274012809 ATP binding site [chemical binding]; other site 316274012810 Mg2+ binding site [ion binding]; other site 316274012811 G-X-G motif; other site 316274012812 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316274012813 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316274012814 ligand binding site [chemical binding]; other site 316274012815 flexible hinge region; other site 316274012816 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274012817 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274012818 translocation protein TolB; Provisional; Region: tolB; PRK00178 316274012819 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316274012820 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274012821 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 316274012822 DinB superfamily; Region: DinB_2; pfam12867 316274012823 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 316274012824 DinB superfamily; Region: DinB_2; pfam12867 316274012825 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 316274012826 SpoVR like protein; Region: SpoVR; pfam04293 316274012827 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 316274012828 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 316274012829 four helix bundle protein; Region: TIGR02436 316274012830 hypothetical protein; Provisional; Region: PRK05325 316274012831 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 316274012832 AAA ATPase domain; Region: AAA_16; pfam13191 316274012833 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 316274012834 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274012835 Cytochrome P450; Region: p450; pfam00067 316274012836 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 316274012837 active site 316274012838 Zn binding site [ion binding]; other site 316274012839 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316274012840 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316274012841 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 316274012842 homotrimer interaction site [polypeptide binding]; other site 316274012843 active site 316274012844 Uncharacterized conserved protein [Function unknown]; Region: COG0062 316274012845 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 316274012846 putative substrate binding site [chemical binding]; other site 316274012847 putative ATP binding site [chemical binding]; other site 316274012848 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 316274012849 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316274012850 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316274012851 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 316274012852 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 316274012853 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 316274012854 Proteins of 100 residues with WXG; Region: WXG100; cl02005 316274012855 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274012856 metal ion-dependent adhesion site (MIDAS); other site 316274012857 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274012858 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274012859 metal ion-dependent adhesion site (MIDAS); other site 316274012860 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 316274012861 CHAT domain; Region: CHAT; pfam12770 316274012862 Caspase domain; Region: Peptidase_C14; pfam00656 316274012863 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012864 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274012865 RecX family; Region: RecX; cl00936 316274012866 recombinase A; Provisional; Region: recA; PRK09354 316274012867 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 316274012868 hexamer interface [polypeptide binding]; other site 316274012869 Walker A motif; other site 316274012870 ATP binding site [chemical binding]; other site 316274012871 Walker B motif; other site 316274012872 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 316274012873 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 316274012874 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 316274012875 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316274012876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274012877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274012878 WHG domain; Region: WHG; pfam13305 316274012879 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 316274012880 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316274012881 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 316274012882 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 316274012883 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 316274012884 active site 316274012885 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316274012886 IHF - DNA interface [nucleotide binding]; other site 316274012887 IHF dimer interface [polypeptide binding]; other site 316274012888 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316274012889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012890 active site 316274012891 phosphorylation site [posttranslational modification] 316274012892 intermolecular recognition site; other site 316274012893 dimerization interface [polypeptide binding]; other site 316274012894 ANTAR domain; Region: ANTAR; pfam03861 316274012895 malate dehydrogenase; Reviewed; Region: PRK06223 316274012896 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 316274012897 NAD(P) binding site [chemical binding]; other site 316274012898 dimer interface [polypeptide binding]; other site 316274012899 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274012900 substrate binding site [chemical binding]; other site 316274012901 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 316274012902 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316274012903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274012904 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316274012905 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316274012906 carboxyltransferase (CT) interaction site; other site 316274012907 biotinylation site [posttranslational modification]; other site 316274012908 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274012909 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274012910 metal ion-dependent adhesion site (MIDAS); other site 316274012911 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 316274012912 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274012913 metal ion-dependent adhesion site (MIDAS); other site 316274012914 Double zinc ribbon; Region: DZR; pfam12773 316274012915 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316274012916 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274012917 substrate binding site [chemical binding]; other site 316274012918 activation loop (A-loop); other site 316274012919 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316274012920 Protein phosphatase 2C; Region: PP2C; pfam00481 316274012921 active site 316274012922 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274012923 metal ion-dependent adhesion site (MIDAS); other site 316274012924 glutamate racemase; Provisional; Region: PRK00865 316274012925 Peptidase C26; Region: Peptidase_C26; pfam07722 316274012926 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 316274012927 catalytic triad [active] 316274012928 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274012929 GAF domain; Region: GAF_2; pfam13185 316274012930 GAF domain; Region: GAF; pfam01590 316274012931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316274012932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274012933 metal binding site [ion binding]; metal-binding site 316274012934 active site 316274012935 I-site; other site 316274012936 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 316274012937 MgtE intracellular N domain; Region: MgtE_N; pfam03448 316274012938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 316274012939 Divalent cation transporter; Region: MgtE; pfam01769 316274012940 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274012941 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274012942 active site 316274012943 catalytic tetrad [active] 316274012944 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 316274012945 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274012946 active site 316274012947 Response regulator receiver domain; Region: Response_reg; pfam00072 316274012948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274012949 active site 316274012950 phosphorylation site [posttranslational modification] 316274012951 intermolecular recognition site; other site 316274012952 dimerization interface [polypeptide binding]; other site 316274012953 TPR repeat; Region: TPR_11; pfam13414 316274012954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012955 binding surface 316274012956 TPR repeat; Region: TPR_11; pfam13414 316274012957 TPR motif; other site 316274012958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274012959 binding surface 316274012960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274012961 TPR motif; other site 316274012962 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274012963 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 316274012964 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 316274012965 active site 316274012966 multimer interface [polypeptide binding]; other site 316274012967 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316274012968 GTPase CgtA; Reviewed; Region: obgE; PRK12297 316274012969 GTP1/OBG; Region: GTP1_OBG; pfam01018 316274012970 Obg GTPase; Region: Obg; cd01898 316274012971 G1 box; other site 316274012972 GTP/Mg2+ binding site [chemical binding]; other site 316274012973 Switch I region; other site 316274012974 G2 box; other site 316274012975 G3 box; other site 316274012976 Switch II region; other site 316274012977 G4 box; other site 316274012978 G5 box; other site 316274012979 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 316274012980 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 316274012981 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316274012982 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 316274012983 PLD-like domain; Region: PLDc_2; pfam13091 316274012984 putative active site [active] 316274012985 catalytic site [active] 316274012986 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 316274012987 PLD-like domain; Region: PLDc_2; pfam13091 316274012988 putative active site [active] 316274012989 catalytic site [active] 316274012990 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316274012991 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316274012992 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274012993 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 316274012994 Walker A/P-loop; other site 316274012995 ATP binding site [chemical binding]; other site 316274012996 Q-loop/lid; other site 316274012997 ABC transporter signature motif; other site 316274012998 Walker B; other site 316274012999 D-loop; other site 316274013000 H-loop/switch region; other site 316274013001 hypothetical protein; Provisional; Region: PRK08317 316274013002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013003 S-adenosylmethionine binding site [chemical binding]; other site 316274013004 Predicted transcriptional regulators [Transcription]; Region: COG1695 316274013005 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 316274013006 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 316274013007 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316274013008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274013009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013010 active site 316274013011 phosphorylation site [posttranslational modification] 316274013012 intermolecular recognition site; other site 316274013013 dimerization interface [polypeptide binding]; other site 316274013014 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 316274013015 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 316274013016 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 316274013017 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 316274013018 acyl-activating enzyme (AAE) consensus motif; other site 316274013019 putative AMP binding site [chemical binding]; other site 316274013020 putative active site [active] 316274013021 putative CoA binding site [chemical binding]; other site 316274013022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013023 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013024 active site 316274013025 phosphorylation site [posttranslational modification] 316274013026 intermolecular recognition site; other site 316274013027 dimerization interface [polypeptide binding]; other site 316274013028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013029 GAF domain; Region: GAF; pfam01590 316274013030 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274013031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013032 putative active site [active] 316274013033 heme pocket [chemical binding]; other site 316274013034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013035 dimer interface [polypeptide binding]; other site 316274013036 phosphorylation site [posttranslational modification] 316274013037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013038 ATP binding site [chemical binding]; other site 316274013039 Mg2+ binding site [ion binding]; other site 316274013040 G-X-G motif; other site 316274013041 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013043 active site 316274013044 phosphorylation site [posttranslational modification] 316274013045 intermolecular recognition site; other site 316274013046 dimerization interface [polypeptide binding]; other site 316274013047 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274013048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013049 active site 316274013050 phosphorylation site [posttranslational modification] 316274013051 intermolecular recognition site; other site 316274013052 dimerization interface [polypeptide binding]; other site 316274013053 enoyl-CoA hydratase; Provisional; Region: PRK06688 316274013054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316274013055 substrate binding site [chemical binding]; other site 316274013056 oxyanion hole (OAH) forming residues; other site 316274013057 trimer interface [polypeptide binding]; other site 316274013058 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 316274013059 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 316274013060 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 316274013061 catalytic site [active] 316274013062 subunit interface [polypeptide binding]; other site 316274013063 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316274013064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274013065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274013066 DNA binding residues [nucleotide binding] 316274013067 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274013068 amidase catalytic site [active] 316274013069 Zn binding residues [ion binding]; other site 316274013070 substrate binding site [chemical binding]; other site 316274013071 PA14 domain; Region: PA14; cl08459 316274013072 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274013073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 316274013074 putative substrate translocation pore; other site 316274013075 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 316274013076 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 316274013077 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 316274013078 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 316274013079 putative active site [active] 316274013080 Zn binding site [ion binding]; other site 316274013081 Cytochrome c; Region: Cytochrom_C; pfam00034 316274013082 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316274013083 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 316274013084 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 316274013085 heme bH binding site [chemical binding]; other site 316274013086 intrachain domain interface; other site 316274013087 Qi binding site; other site 316274013088 heme bL binding site [chemical binding]; other site 316274013089 interchain domain interface [polypeptide binding]; other site 316274013090 Qo binding site; other site 316274013091 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 316274013092 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 316274013093 iron-sulfur cluster [ion binding]; other site 316274013094 [2Fe-2S] cluster binding site [ion binding]; other site 316274013095 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274013096 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274013097 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013099 active site 316274013100 phosphorylation site [posttranslational modification] 316274013101 intermolecular recognition site; other site 316274013102 dimerization interface [polypeptide binding]; other site 316274013103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274013105 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316274013106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013107 putative active site [active] 316274013108 heme pocket [chemical binding]; other site 316274013109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013110 dimer interface [polypeptide binding]; other site 316274013111 phosphorylation site [posttranslational modification] 316274013112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013113 ATP binding site [chemical binding]; other site 316274013114 Mg2+ binding site [ion binding]; other site 316274013115 G-X-G motif; other site 316274013116 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274013117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013118 active site 316274013119 phosphorylation site [posttranslational modification] 316274013120 intermolecular recognition site; other site 316274013121 dimerization interface [polypeptide binding]; other site 316274013122 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 316274013123 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 316274013124 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274013125 WYL domain; Region: WYL; pfam13280 316274013126 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 316274013127 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316274013128 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 316274013129 active site 316274013130 HIGH motif; other site 316274013131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274013132 active site 316274013133 KMSKS motif; other site 316274013134 DALR domain; Region: DALR_2; pfam09190 316274013135 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 316274013136 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 316274013137 RDD family; Region: RDD; pfam06271 316274013138 Integral membrane protein DUF95; Region: DUF95; pfam01944 316274013139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316274013140 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316274013141 Putative methyltransferase; Region: Methyltransf_4; cl17290 316274013142 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274013143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013144 S-adenosylmethionine binding site [chemical binding]; other site 316274013145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013146 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013147 Predicted membrane protein [Function unknown]; Region: COG3463 316274013148 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 316274013149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013150 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013151 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316274013152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013153 S-adenosylmethionine binding site [chemical binding]; other site 316274013154 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316274013155 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 316274013156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274013157 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 316274013158 NAD binding site [chemical binding]; other site 316274013159 substrate binding site [chemical binding]; other site 316274013160 homodimer interface [polypeptide binding]; other site 316274013161 active site 316274013162 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 316274013163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013164 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 316274013165 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013167 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274013168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013169 S-adenosylmethionine binding site [chemical binding]; other site 316274013170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274013171 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 316274013172 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 316274013173 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 316274013174 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 316274013175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274013176 minor groove reading motif; other site 316274013177 helix-hairpin-helix signature motif; other site 316274013178 substrate binding pocket [chemical binding]; other site 316274013179 active site 316274013180 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 316274013181 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274013182 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316274013183 catalytic site [active] 316274013184 Isochorismatase family; Region: Isochorismatase; pfam00857 316274013185 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 316274013186 catalytic triad [active] 316274013187 conserved cis-peptide bond; other site 316274013188 Predicted amidohydrolase [General function prediction only]; Region: COG0388 316274013189 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 316274013190 active site 316274013191 catalytic triad [active] 316274013192 dimer interface [polypeptide binding]; other site 316274013193 NAD synthetase; Provisional; Region: PRK13980 316274013194 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 316274013195 homodimer interface [polypeptide binding]; other site 316274013196 NAD binding pocket [chemical binding]; other site 316274013197 ATP binding pocket [chemical binding]; other site 316274013198 Mg binding site [ion binding]; other site 316274013199 active-site loop [active] 316274013200 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274013201 nudix motif; other site 316274013202 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 316274013203 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 316274013204 30S subunit binding site; other site 316274013205 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316274013206 catalytic core [active] 316274013207 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 316274013208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274013209 Coenzyme A binding pocket [chemical binding]; other site 316274013210 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 316274013211 TIGR02588 family protein; Region: TIGR02588 316274013212 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 316274013213 Thymidylate synthase complementing protein; Region: Thy1; cl03630 316274013214 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 316274013215 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 316274013216 The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; Region: THUMP; smart00981 316274013217 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 316274013218 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461 316274013219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274013220 FeS/SAM binding site; other site 316274013221 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 316274013222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013223 active site 316274013224 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 316274013225 phosphorylation site [posttranslational modification] 316274013226 intermolecular recognition site; other site 316274013227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013228 active site 316274013229 phosphorylation site [posttranslational modification] 316274013230 intermolecular recognition site; other site 316274013231 dimerization interface [polypeptide binding]; other site 316274013232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316274013233 metal binding site [ion binding]; metal-binding site 316274013234 active site 316274013235 I-site; other site 316274013236 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 316274013237 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274013238 nudix motif; other site 316274013239 Protein kinase domain; Region: Pkinase; pfam00069 316274013240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013241 active site 316274013242 ATP binding site [chemical binding]; other site 316274013243 substrate binding site [chemical binding]; other site 316274013244 activation loop (A-loop); other site 316274013245 TPR repeat; Region: TPR_11; pfam13414 316274013246 TPR repeat; Region: TPR_11; pfam13414 316274013247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274013248 binding surface 316274013249 TPR motif; other site 316274013250 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274013251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274013252 binding surface 316274013253 TPR motif; other site 316274013254 TPR repeat; Region: TPR_11; pfam13414 316274013255 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274013256 nudix motif; other site 316274013257 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274013258 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274013259 Probable Catalytic site; other site 316274013260 metal-binding site 316274013261 mevalonate kinase; Region: mevalon_kin; TIGR00549 316274013262 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316274013263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316274013264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274013265 Coenzyme A binding pocket [chemical binding]; other site 316274013266 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316274013267 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316274013268 Protein export membrane protein; Region: SecD_SecF; cl14618 316274013269 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274013270 MarR family; Region: MarR_2; pfam12802 316274013271 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 316274013272 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 316274013273 active site 316274013274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274013275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013276 active site 316274013277 ATP binding site [chemical binding]; other site 316274013278 substrate binding site [chemical binding]; other site 316274013279 activation loop (A-loop); other site 316274013280 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316274013281 nudix motif; other site 316274013282 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 316274013283 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316274013284 inhibitor-cofactor binding pocket; inhibition site 316274013285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274013286 catalytic residue [active] 316274013287 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274013288 extended (e) SDRs; Region: SDR_e; cd08946 316274013289 NAD(P) binding site [chemical binding]; other site 316274013290 active site 316274013291 substrate binding site [chemical binding]; other site 316274013292 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013293 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316274013294 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274013295 metal-binding site [ion binding] 316274013296 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316274013297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274013298 metal-binding site [ion binding] 316274013299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274013300 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316274013301 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316274013302 metal-binding site [ion binding] 316274013303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013304 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013305 Helix-turn-helix domain; Region: HTH_17; pfam12728 316274013306 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316274013307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013308 S-adenosylmethionine binding site [chemical binding]; other site 316274013309 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 316274013310 Flavoprotein; Region: Flavoprotein; pfam02441 316274013311 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274013312 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 316274013313 active site 316274013314 Divergent AAA domain; Region: AAA_4; pfam04326 316274013315 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 316274013316 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316274013317 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 316274013318 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 316274013319 putative active site [active] 316274013320 putative catalytic site [active] 316274013321 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 316274013322 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 316274013323 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 316274013324 homodimer interface [polypeptide binding]; other site 316274013325 maltodextrin glucosidase; Provisional; Region: PRK10785 316274013326 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 316274013327 active site 316274013328 homodimer interface [polypeptide binding]; other site 316274013329 catalytic site [active] 316274013330 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316274013331 Interdomain contacts; other site 316274013332 Cytokine receptor motif; other site 316274013333 Starch binding domain; Region: CBM_2; smart01065 316274013334 Bacterial Ig-like domain; Region: Big_5; pfam13205 316274013335 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 316274013336 maltodextrin glucosidase; Provisional; Region: PRK10785 316274013337 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 316274013338 active site 316274013339 homodimer interface [polypeptide binding]; other site 316274013340 catalytic site [active] 316274013341 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 316274013342 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274013343 DNA binding site [nucleotide binding] 316274013344 active site 316274013345 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 316274013346 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274013347 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316274013348 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316274013349 TM-ABC transporter signature motif; other site 316274013350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274013351 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316274013352 Walker A/P-loop; other site 316274013353 ATP binding site [chemical binding]; other site 316274013354 Q-loop/lid; other site 316274013355 ABC transporter signature motif; other site 316274013356 Walker B; other site 316274013357 D-loop; other site 316274013358 H-loop/switch region; other site 316274013359 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 316274013360 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274013361 putative ligand binding site [chemical binding]; other site 316274013362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013364 active site 316274013365 phosphorylation site [posttranslational modification] 316274013366 intermolecular recognition site; other site 316274013367 dimerization interface [polypeptide binding]; other site 316274013368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274013369 DNA binding residues [nucleotide binding] 316274013370 dimerization interface [polypeptide binding]; other site 316274013371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013372 active site 316274013373 phosphorylation site [posttranslational modification] 316274013374 intermolecular recognition site; other site 316274013375 seryl-tRNA synthetase; Provisional; Region: PRK05431 316274013376 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 316274013377 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 316274013378 dimer interface [polypeptide binding]; other site 316274013379 active site 316274013380 motif 1; other site 316274013381 motif 2; other site 316274013382 motif 3; other site 316274013383 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 316274013384 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 316274013385 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 316274013386 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 316274013387 active site 316274013388 NAD binding site [chemical binding]; other site 316274013389 metal binding site [ion binding]; metal-binding site 316274013390 CpXC protein; Region: CpXC; pfam14353 316274013391 CpXC protein; Region: CpXC; pfam14353 316274013392 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316274013393 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 316274013394 acyl-activating enzyme (AAE) consensus motif; other site 316274013395 putative AMP binding site [chemical binding]; other site 316274013396 putative active site [active] 316274013397 putative CoA binding site [chemical binding]; other site 316274013398 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 316274013399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274013400 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274013401 Coenzyme A binding pocket [chemical binding]; other site 316274013402 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316274013403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013404 active site 316274013405 phosphorylation site [posttranslational modification] 316274013406 intermolecular recognition site; other site 316274013407 dimerization interface [polypeptide binding]; other site 316274013408 ANTAR domain; Region: ANTAR; pfam03861 316274013409 Bifunctional nuclease; Region: DNase-RNase; pfam02577 316274013410 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 316274013411 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 316274013412 quinone interaction residues [chemical binding]; other site 316274013413 active site 316274013414 catalytic residues [active] 316274013415 FMN binding site [chemical binding]; other site 316274013416 substrate binding site [chemical binding]; other site 316274013417 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 316274013418 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 316274013419 Galactose oxidase, central domain; Region: Kelch_3; cl02701 316274013420 Galactose oxidase, central domain; Region: Kelch_3; cl02701 316274013421 Kelch domain; Region: Kelch; smart00612 316274013422 Kelch motif; Region: Kelch_1; pfam01344 316274013423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274013424 Zn2+ binding site [ion binding]; other site 316274013425 Mg2+ binding site [ion binding]; other site 316274013426 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316274013427 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 316274013428 active site 316274013429 metal binding site [ion binding]; metal-binding site 316274013430 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316274013431 Predicted dehydrogenase [General function prediction only]; Region: COG5322 316274013432 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 316274013433 NAD(P) binding pocket [chemical binding]; other site 316274013434 Double zinc ribbon; Region: DZR; pfam12773 316274013435 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 316274013436 pentamer interface [polypeptide binding]; other site 316274013437 dodecaamer interface [polypeptide binding]; other site 316274013438 Uncharacterized conserved protein [Function unknown]; Region: COG5276 316274013439 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 316274013440 PA/protease or protease-like domain interface [polypeptide binding]; other site 316274013441 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316274013442 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 316274013443 nucleophilic elbow; other site 316274013444 catalytic triad; other site 316274013445 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316274013446 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274013447 dimer interface [polypeptide binding]; other site 316274013448 ssDNA binding site [nucleotide binding]; other site 316274013449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274013450 KTSC domain; Region: KTSC; pfam13619 316274013451 DNA topoisomerase II large subunit; Provisional; Region: 39; PHA02569 316274013452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013453 ATP binding site [chemical binding]; other site 316274013454 Mg2+ binding site [ion binding]; other site 316274013455 G-X-G motif; other site 316274013456 Src homology 2 (SH2) domain; Region: SH2; cl15255 316274013457 hydrophobic binding pocket [polypeptide binding]; other site 316274013458 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 316274013459 anchoring element; other site 316274013460 dimer interface [polypeptide binding]; other site 316274013461 ATP binding site [chemical binding]; other site 316274013462 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 316274013463 active site 316274013464 metal binding site [ion binding]; metal-binding site 316274013465 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 316274013466 protein-splicing catalytic site; other site 316274013467 thioester formation/cholesterol transfer; other site 316274013468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274013469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274013470 non-specific DNA binding site [nucleotide binding]; other site 316274013471 salt bridge; other site 316274013472 sequence-specific DNA binding site [nucleotide binding]; other site 316274013473 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 316274013474 active site 316274013475 metal binding site [ion binding]; metal-binding site 316274013476 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 316274013477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013478 GAF domain; Region: GAF_3; pfam13492 316274013479 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274013480 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274013481 HSP90 family protein; Provisional; Region: PRK14083 316274013482 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 316274013483 ATP binding site [chemical binding]; other site 316274013484 Mg2+ binding site [ion binding]; other site 316274013485 G-X-G motif; other site 316274013486 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 316274013487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013488 ATP binding site [chemical binding]; other site 316274013489 Mg2+ binding site [ion binding]; other site 316274013490 G-X-G motif; other site 316274013491 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274013492 active site 316274013493 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 316274013494 putative active site [active] 316274013495 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316274013496 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316274013497 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 316274013498 Bacterial SH3 domain; Region: SH3_3; pfam08239 316274013499 Bacterial SH3 domain homologues; Region: SH3b; smart00287 316274013500 Bacterial SH3 domain homologues; Region: SH3b; smart00287 316274013501 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316274013502 NlpC/P60 family; Region: NLPC_P60; pfam00877 316274013503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013504 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274013505 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 316274013506 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 316274013507 NAD binding site [chemical binding]; other site 316274013508 homodimer interface [polypeptide binding]; other site 316274013509 homotetramer interface [polypeptide binding]; other site 316274013510 active site 316274013511 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274013512 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 316274013513 dimer interface [polypeptide binding]; other site 316274013514 active site 316274013515 DNA topoisomerase I; Validated; Region: PRK06599 316274013516 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 316274013517 active site 316274013518 interdomain interaction site; other site 316274013519 putative metal-binding site [ion binding]; other site 316274013520 nucleotide binding site [chemical binding]; other site 316274013521 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 316274013522 domain I; other site 316274013523 DNA binding groove [nucleotide binding] 316274013524 phosphate binding site [ion binding]; other site 316274013525 domain II; other site 316274013526 domain III; other site 316274013527 nucleotide binding site [chemical binding]; other site 316274013528 catalytic site [active] 316274013529 domain IV; other site 316274013530 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316274013531 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 316274013532 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316274013533 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316274013534 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316274013535 cobalamin synthase; Reviewed; Region: cobS; PRK00235 316274013536 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274013537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274013538 active site 316274013539 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 316274013540 active site 316274013541 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 316274013542 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 316274013543 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316274013544 dimer interface [polypeptide binding]; other site 316274013545 active site 316274013546 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 316274013547 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316274013548 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274013549 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316274013550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316274013551 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 316274013552 substrate binding site [chemical binding]; other site 316274013553 oxyanion hole (OAH) forming residues; other site 316274013554 trimer interface [polypeptide binding]; other site 316274013555 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316274013556 MarR family; Region: MarR; pfam01047 316274013557 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 316274013558 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 316274013559 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 316274013560 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 316274013561 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 316274013562 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316274013563 endonuclease III; Region: ENDO3c; smart00478 316274013564 minor groove reading motif; other site 316274013565 helix-hairpin-helix signature motif; other site 316274013566 substrate binding pocket [chemical binding]; other site 316274013567 active site 316274013568 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 316274013569 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 316274013570 Response regulator receiver domain; Region: Response_reg; pfam00072 316274013571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013572 active site 316274013573 phosphorylation site [posttranslational modification] 316274013574 intermolecular recognition site; other site 316274013575 dimerization interface [polypeptide binding]; other site 316274013576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013577 dimer interface [polypeptide binding]; other site 316274013578 phosphorylation site [posttranslational modification] 316274013579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013580 ATP binding site [chemical binding]; other site 316274013581 Mg2+ binding site [ion binding]; other site 316274013582 G-X-G motif; other site 316274013583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316274013584 catalytic residues [active] 316274013585 adenylate kinase; Reviewed; Region: adk; PRK00279 316274013586 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316274013587 AMP-binding site [chemical binding]; other site 316274013588 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316274013589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316274013590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274013591 S-adenosylmethionine binding site [chemical binding]; other site 316274013592 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 316274013593 active site 316274013594 intersubunit interactions; other site 316274013595 catalytic residue [active] 316274013596 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316274013597 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 316274013598 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 316274013599 Fe-S cluster binding site [ion binding]; other site 316274013600 active site 316274013601 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 316274013602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 316274013603 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 316274013604 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274013605 active site 316274013606 catalytic triad [active] 316274013607 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013608 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013609 Cna protein B-type domain; Region: Cna_B_2; pfam13715 316274013610 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013611 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 316274013612 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316274013613 active site 316274013614 catalytic triad [active] 316274013615 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013616 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013617 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013618 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013619 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 316274013620 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 316274013621 HIGH motif; other site 316274013622 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316274013623 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316274013624 active site 316274013625 KMSKS motif; other site 316274013626 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 316274013627 tRNA binding surface [nucleotide binding]; other site 316274013628 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013629 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013630 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274013631 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 316274013632 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 316274013633 CoA binding domain; Region: CoA_binding; smart00881 316274013634 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274013635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013636 active site 316274013637 phosphorylation site [posttranslational modification] 316274013638 dimerization interface [polypeptide binding]; other site 316274013639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274013640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013641 ATP binding site [chemical binding]; other site 316274013642 Mg2+ binding site [ion binding]; other site 316274013643 G-X-G motif; other site 316274013644 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274013645 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 316274013646 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 316274013647 active site 316274013648 catalytic residues [active] 316274013649 metal binding site [ion binding]; metal-binding site 316274013650 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274013651 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 316274013652 NAD binding site [chemical binding]; other site 316274013653 putative substrate binding site 2 [chemical binding]; other site 316274013654 putative substrate binding site 1 [chemical binding]; other site 316274013655 active site 316274013656 O-Antigen ligase; Region: Wzy_C; pfam04932 316274013657 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316274013658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316274013659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274013660 NAD(P) binding site [chemical binding]; other site 316274013661 active site 316274013662 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 316274013663 metal-dependent hydrolase; Provisional; Region: PRK13291 316274013664 DinB superfamily; Region: DinB_2; pfam12867 316274013665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013666 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274013667 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 316274013668 tartrate dehydrogenase; Region: TTC; TIGR02089 316274013669 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 316274013670 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 316274013671 substrate binding site [chemical binding]; other site 316274013672 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 316274013673 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 316274013674 substrate binding site [chemical binding]; other site 316274013675 ligand binding site [chemical binding]; other site 316274013676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274013677 Coenzyme A binding pocket [chemical binding]; other site 316274013678 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 316274013679 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 316274013680 homodimer interface [polypeptide binding]; other site 316274013681 substrate-cofactor binding pocket; other site 316274013682 catalytic residue [active] 316274013683 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 316274013684 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 316274013685 active site 316274013686 catalytic residues [active] 316274013687 metal binding site [ion binding]; metal-binding site 316274013688 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 316274013689 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 316274013690 Prephenate dehydratase; Region: PDT; pfam00800 316274013691 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 316274013692 putative L-Phe binding site [chemical binding]; other site 316274013693 2-isopropylmalate synthase; Validated; Region: PRK00915 316274013694 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 316274013695 active site 316274013696 catalytic residues [active] 316274013697 metal binding site [ion binding]; metal-binding site 316274013698 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 316274013699 ketol-acid reductoisomerase; Provisional; Region: PRK05479 316274013700 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 316274013701 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 316274013702 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 316274013703 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 316274013704 putative valine binding site [chemical binding]; other site 316274013705 dimer interface [polypeptide binding]; other site 316274013706 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 316274013707 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 316274013708 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 316274013709 PYR/PP interface [polypeptide binding]; other site 316274013710 dimer interface [polypeptide binding]; other site 316274013711 TPP binding site [chemical binding]; other site 316274013712 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 316274013713 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 316274013714 TPP-binding site [chemical binding]; other site 316274013715 dimer interface [polypeptide binding]; other site 316274013716 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 316274013717 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 316274013718 HEAT repeats; Region: HEAT_2; pfam13646 316274013719 HEAT repeats; Region: HEAT_2; pfam13646 316274013720 HEAT repeats; Region: HEAT_2; pfam13646 316274013721 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 316274013722 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 316274013723 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316274013724 4Fe-4S binding domain; Region: Fer4_2; pfam12797 316274013725 Cysteine-rich domain; Region: CCG; pfam02754 316274013726 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274013727 Cysteine-rich domain; Region: CCG; pfam02754 316274013728 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 316274013729 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316274013730 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274013731 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316274013732 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 316274013733 N-terminal catalytic domain of Gh57 branching enzyme TK 1436 and similar proteins; Region: GH57N_BE_TK1436_like; cd10816 316274013734 Uncharacterized conserved protein [Function unknown]; Region: COG1543 316274013735 active site 316274013736 substrate binding site [chemical binding]; other site 316274013737 catalytic site [active] 316274013738 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 316274013739 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274013740 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274013741 active site 316274013742 catalytic tetrad [active] 316274013743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274013744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274013745 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 316274013746 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 316274013747 conserved repeat domain; Region: B_ant_repeat; TIGR01451 316274013748 YceG-like family; Region: YceG; pfam02618 316274013749 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 316274013750 dimerization interface [polypeptide binding]; other site 316274013751 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 316274013752 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 316274013753 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 316274013754 shikimate binding site; other site 316274013755 NAD(P) binding site [chemical binding]; other site 316274013756 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 316274013757 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 316274013758 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 316274013759 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 316274013760 homodimer interface [polypeptide binding]; other site 316274013761 NADP binding site [chemical binding]; other site 316274013762 substrate binding site [chemical binding]; other site 316274013763 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274013764 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274013765 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316274013766 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274013767 active site 316274013768 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 316274013769 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274013770 Zn2+ binding site [ion binding]; other site 316274013771 Mg2+ binding site [ion binding]; other site 316274013772 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 316274013773 synthetase active site [active] 316274013774 NTP binding site [chemical binding]; other site 316274013775 metal binding site [ion binding]; metal-binding site 316274013776 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 316274013777 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 316274013778 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 316274013779 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 316274013780 active site 316274013781 dimer interface [polypeptide binding]; other site 316274013782 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 316274013783 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 316274013784 active site 316274013785 FMN binding site [chemical binding]; other site 316274013786 substrate binding site [chemical binding]; other site 316274013787 3Fe-4S cluster binding site [ion binding]; other site 316274013788 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 316274013789 domain_subunit interface; other site 316274013790 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274013791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274013792 putative active site [active] 316274013793 heme pocket [chemical binding]; other site 316274013794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013795 dimer interface [polypeptide binding]; other site 316274013796 phosphorylation site [posttranslational modification] 316274013797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013798 ATP binding site [chemical binding]; other site 316274013799 Mg2+ binding site [ion binding]; other site 316274013800 G-X-G motif; other site 316274013801 Bacterial Ig-like domain; Region: Big_5; pfam13205 316274013802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274013803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274013804 active site 316274013805 phosphorylation site [posttranslational modification] 316274013806 intermolecular recognition site; other site 316274013807 dimerization interface [polypeptide binding]; other site 316274013808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274013809 DNA binding residues [nucleotide binding] 316274013810 dimerization interface [polypeptide binding]; other site 316274013811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013812 GAF domain; Region: GAF_3; pfam13492 316274013813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274013814 GAF domain; Region: GAF; cl17456 316274013815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274013816 Histidine kinase; Region: HisKA_3; pfam07730 316274013817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013818 ATP binding site [chemical binding]; other site 316274013819 Mg2+ binding site [ion binding]; other site 316274013820 G-X-G motif; other site 316274013821 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 316274013822 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 316274013823 Substrate binding site; other site 316274013824 Mg++ binding site; other site 316274013825 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 316274013826 active site 316274013827 substrate binding site [chemical binding]; other site 316274013828 CoA binding site [chemical binding]; other site 316274013829 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 316274013830 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 316274013831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274013832 active site 316274013833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013834 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013835 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274013836 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274013837 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274013838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013839 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274013840 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316274013841 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 316274013842 substrate binding pocket [chemical binding]; other site 316274013843 chain length determination region; other site 316274013844 substrate-Mg2+ binding site; other site 316274013845 catalytic residues [active] 316274013846 aspartate-rich region 1; other site 316274013847 active site lid residues [active] 316274013848 aspartate-rich region 2; other site 316274013849 Penicillinase repressor; Region: Pencillinase_R; pfam03965 316274013850 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 316274013851 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316274013852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274013853 FeS/SAM binding site; other site 316274013854 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316274013855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274013856 Coenzyme A binding pocket [chemical binding]; other site 316274013857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274013858 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 316274013859 6-phosphofructokinase; Provisional; Region: PRK03202 316274013860 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 316274013861 active site 316274013862 ADP/pyrophosphate binding site [chemical binding]; other site 316274013863 dimerization interface [polypeptide binding]; other site 316274013864 allosteric effector site; other site 316274013865 fructose-1,6-bisphosphate binding site; other site 316274013866 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274013867 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274013868 glycogen synthase; Provisional; Region: glgA; PRK00654 316274013869 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316274013870 ADP-binding pocket [chemical binding]; other site 316274013871 homodimer interface [polypeptide binding]; other site 316274013872 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316274013873 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 316274013874 G1 box; other site 316274013875 GTP/Mg2+ binding site [chemical binding]; other site 316274013876 G2 box; other site 316274013877 Switch I region; other site 316274013878 G3 box; other site 316274013879 Switch II region; other site 316274013880 G4 box; other site 316274013881 G5 box; other site 316274013882 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 316274013883 threonine synthase; Reviewed; Region: PRK06721 316274013884 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 316274013885 homodimer interface [polypeptide binding]; other site 316274013886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274013887 catalytic residue [active] 316274013888 aspartate kinase; Provisional; Region: PRK06291 316274013889 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 316274013890 putative catalytic residues [active] 316274013891 nucleotide binding site [chemical binding]; other site 316274013892 aspartate binding site [chemical binding]; other site 316274013893 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 316274013894 dimer interface [polypeptide binding]; other site 316274013895 putative threonine allosteric regulatory site; other site 316274013896 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 316274013897 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316274013898 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316274013899 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316274013900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274013901 Coenzyme A binding pocket [chemical binding]; other site 316274013902 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 316274013903 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 316274013904 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 316274013905 NAD(P) binding site [chemical binding]; other site 316274013906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274013907 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 316274013908 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 316274013909 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 316274013910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316274013911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316274013912 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 316274013913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 316274013914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274013915 catalytic residue [active] 316274013916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274013917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013918 dimer interface [polypeptide binding]; other site 316274013919 phosphorylation site [posttranslational modification] 316274013920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013921 ATP binding site [chemical binding]; other site 316274013922 Mg2+ binding site [ion binding]; other site 316274013923 G-X-G motif; other site 316274013924 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 316274013925 EspG family; Region: ESX-1_EspG; pfam14011 316274013926 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 316274013927 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 316274013928 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 316274013929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274013930 nucleophilic elbow; other site 316274013931 catalytic triad; other site 316274013932 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316274013933 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 316274013934 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316274013935 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274013936 homodimer interface [polypeptide binding]; other site 316274013937 active site 316274013938 TDP-binding site; other site 316274013939 acceptor substrate-binding pocket; other site 316274013940 Putative esterase; Region: Esterase; pfam00756 316274013941 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 316274013942 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 316274013943 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 316274013944 transmembrane helices; other site 316274013945 Asp23 family; Region: Asp23; cl00574 316274013946 Haemolysin XhlA; Region: XhlA; pfam10779 316274013947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274013948 dimerization interface [polypeptide binding]; other site 316274013949 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274013950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274013951 dimer interface [polypeptide binding]; other site 316274013952 phosphorylation site [posttranslational modification] 316274013953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274013954 ATP binding site [chemical binding]; other site 316274013955 Mg2+ binding site [ion binding]; other site 316274013956 G-X-G motif; other site 316274013957 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274013958 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013959 active site 316274013960 ATP binding site [chemical binding]; other site 316274013961 substrate binding site [chemical binding]; other site 316274013962 activation loop (A-loop); other site 316274013963 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013964 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013965 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013966 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274013967 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013968 active site 316274013969 ATP binding site [chemical binding]; other site 316274013970 substrate binding site [chemical binding]; other site 316274013971 activation loop (A-loop); other site 316274013972 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013973 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013974 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274013975 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274013976 active site 316274013977 ATP binding site [chemical binding]; other site 316274013978 substrate binding site [chemical binding]; other site 316274013979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274013980 TPR repeat; Region: TPR_11; pfam13414 316274013981 TPR motif; other site 316274013982 Double zinc ribbon; Region: DZR; pfam12773 316274013983 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274013984 phosphopeptide binding site; other site 316274013985 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274013986 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 316274013987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274013988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274013989 homodimer interface [polypeptide binding]; other site 316274013990 catalytic residue [active] 316274013991 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 316274013992 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 316274013993 active site 316274013994 large tegument protein UL36; Provisional; Region: PHA03247 316274013995 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 316274013996 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 316274013997 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 316274013998 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316274013999 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 316274014000 active site 316274014001 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 316274014002 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 316274014003 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 316274014004 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316274014005 ferric uptake regulator; Provisional; Region: fur; PRK09462 316274014006 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316274014007 metal binding site 2 [ion binding]; metal-binding site 316274014008 putative DNA binding helix; other site 316274014009 metal binding site 1 [ion binding]; metal-binding site 316274014010 dimer interface [polypeptide binding]; other site 316274014011 structural Zn2+ binding site [ion binding]; other site 316274014012 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 316274014013 DNA protecting protein DprA; Region: dprA; TIGR00732 316274014014 PAS domain S-box; Region: sensory_box; TIGR00229 316274014015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274014016 putative active site [active] 316274014017 heme pocket [chemical binding]; other site 316274014018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014019 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274014021 PAS fold; Region: PAS_3; pfam08447 316274014022 putative active site [active] 316274014023 heme pocket [chemical binding]; other site 316274014024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274014025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014026 dimer interface [polypeptide binding]; other site 316274014027 phosphorylation site [posttranslational modification] 316274014028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014029 ATP binding site [chemical binding]; other site 316274014030 Mg2+ binding site [ion binding]; other site 316274014031 G-X-G motif; other site 316274014032 Response regulator receiver domain; Region: Response_reg; pfam00072 316274014033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014034 active site 316274014035 phosphorylation site [posttranslational modification] 316274014036 intermolecular recognition site; other site 316274014037 dimerization interface [polypeptide binding]; other site 316274014038 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 316274014039 ligand binding site [chemical binding]; other site 316274014040 active site 316274014041 UGI interface [polypeptide binding]; other site 316274014042 catalytic site [active] 316274014043 CHRD domain; Region: CHRD; pfam07452 316274014044 CHRD domain; Region: CHRD; pfam07452 316274014045 CHRD domain; Region: CHRD; pfam07452 316274014046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274014047 Coenzyme A binding pocket [chemical binding]; other site 316274014048 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 316274014049 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316274014050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274014051 ATP binding site [chemical binding]; other site 316274014052 putative Mg++ binding site [ion binding]; other site 316274014053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274014054 nucleotide binding region [chemical binding]; other site 316274014055 ATP-binding site [chemical binding]; other site 316274014056 HRDC domain; Region: HRDC; pfam00570 316274014057 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 316274014058 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316274014059 inhibitor-cofactor binding pocket; inhibition site 316274014060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274014061 catalytic residue [active] 316274014062 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 316274014063 putative ADP-ribose binding site [chemical binding]; other site 316274014064 putative active site [active] 316274014065 CAAX protease self-immunity; Region: Abi; pfam02517 316274014066 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 316274014067 aspartate racemase; Region: asp_race; TIGR00035 316274014068 TPR repeat; Region: TPR_11; pfam13414 316274014069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274014070 binding surface 316274014071 TPR motif; other site 316274014072 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 316274014073 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316274014074 Cysteine-rich domain; Region: CCG; pfam02754 316274014075 Cysteine-rich domain; Region: CCG; pfam02754 316274014076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274014077 dimerization interface [polypeptide binding]; other site 316274014078 putative DNA binding site [nucleotide binding]; other site 316274014079 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316274014080 putative Zn2+ binding site [ion binding]; other site 316274014081 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316274014082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316274014083 nucleotide binding site [chemical binding]; other site 316274014084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 316274014085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 316274014086 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316274014087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274014088 dimer interface [polypeptide binding]; other site 316274014089 conserved gate region; other site 316274014090 putative PBP binding loops; other site 316274014091 ABC-ATPase subunit interface; other site 316274014092 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274014093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 316274014094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316274014095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274014096 putative PBP binding loops; other site 316274014097 dimer interface [polypeptide binding]; other site 316274014098 ABC-ATPase subunit interface; other site 316274014099 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 316274014100 CoA binding domain; Region: CoA_binding; smart00881 316274014101 CoA-ligase; Region: Ligase_CoA; pfam00549 316274014102 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274014103 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274014104 NADP-binding site; other site 316274014105 homotetramer interface [polypeptide binding]; other site 316274014106 substrate binding site [chemical binding]; other site 316274014107 homodimer interface [polypeptide binding]; other site 316274014108 active site 316274014109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274014110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274014111 non-specific DNA binding site [nucleotide binding]; other site 316274014112 salt bridge; other site 316274014113 sequence-specific DNA binding site [nucleotide binding]; other site 316274014114 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 316274014115 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 316274014116 CoA-ligase; Region: Ligase_CoA; pfam00549 316274014117 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 316274014118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274014119 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 316274014120 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 316274014121 active site 316274014122 tetramer interface [polypeptide binding]; other site 316274014123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316274014124 active site 316274014125 putative anti-sigmaE protein; Provisional; Region: PRK13920 316274014126 Anti-sigma-K factor rskA; Region: RskA; pfam10099 316274014127 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 316274014128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274014129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274014130 DNA binding residues [nucleotide binding] 316274014131 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 316274014132 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 316274014133 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 316274014134 putative sugar binding sites [chemical binding]; other site 316274014135 Q-X-W motif; other site 316274014136 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 316274014137 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 316274014138 putative sugar binding sites [chemical binding]; other site 316274014139 Q-X-W motif; other site 316274014140 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 316274014141 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 316274014142 G1 box; other site 316274014143 putative GEF interaction site [polypeptide binding]; other site 316274014144 GTP/Mg2+ binding site [chemical binding]; other site 316274014145 Switch I region; other site 316274014146 G2 box; other site 316274014147 G3 box; other site 316274014148 Switch II region; other site 316274014149 G4 box; other site 316274014150 G5 box; other site 316274014151 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 316274014152 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 316274014153 Restriction endonuclease; Region: Mrr_cat; pfam04471 316274014154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274014155 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274014156 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316274014157 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 316274014158 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316274014159 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316274014160 Walker A/P-loop; other site 316274014161 ATP binding site [chemical binding]; other site 316274014162 Q-loop/lid; other site 316274014163 ABC transporter signature motif; other site 316274014164 Walker B; other site 316274014165 D-loop; other site 316274014166 H-loop/switch region; other site 316274014167 MarR family; Region: MarR_2; cl17246 316274014168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274014169 dimerization interface [polypeptide binding]; other site 316274014170 putative DNA binding site [nucleotide binding]; other site 316274014171 putative Zn2+ binding site [ion binding]; other site 316274014172 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 316274014173 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 316274014174 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316274014175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316274014176 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 316274014177 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316274014178 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 316274014179 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 316274014180 Low molecular weight phosphatase family; Region: LMWPc; cd00115 316274014181 active site 316274014182 FG-GAP repeat; Region: FG-GAP; cl15299 316274014183 FG-GAP repeat; Region: FG-GAP; cl15299 316274014184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316274014185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316274014186 active site 316274014187 catalytic tetrad [active] 316274014188 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 316274014189 active site 316274014190 catalytic motif [active] 316274014191 Zn binding site [ion binding]; other site 316274014192 Domain of unknown function DUF21; Region: DUF21; pfam01595 316274014193 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316274014194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316274014195 Transporter associated domain; Region: CorC_HlyC; smart01091 316274014196 hypothetical protein; Validated; Region: PRK07682 316274014197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316274014198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316274014199 homodimer interface [polypeptide binding]; other site 316274014200 catalytic residue [active] 316274014201 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274014202 Ligand binding site; other site 316274014203 Putative Catalytic site; other site 316274014204 DXD motif; other site 316274014205 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 316274014206 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 316274014207 GDP-binding site [chemical binding]; other site 316274014208 ACT binding site; other site 316274014209 IMP binding site; other site 316274014210 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 316274014211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274014212 Walker A/P-loop; other site 316274014213 ATP binding site [chemical binding]; other site 316274014214 Q-loop/lid; other site 316274014215 ABC transporter signature motif; other site 316274014216 Walker B; other site 316274014217 D-loop; other site 316274014218 H-loop/switch region; other site 316274014219 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 316274014220 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 316274014221 SnoaL-like domain; Region: SnoaL_3; pfam13474 316274014222 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 316274014223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274014224 S-adenosylmethionine binding site [chemical binding]; other site 316274014225 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 316274014226 Part of AAA domain; Region: AAA_19; pfam13245 316274014227 Family description; Region: UvrD_C_2; pfam13538 316274014228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316274014229 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316274014230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274014231 ABC-ATPase subunit interface; other site 316274014232 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316274014233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316274014234 dimer interface [polypeptide binding]; other site 316274014235 conserved gate region; other site 316274014236 putative PBP binding loops; other site 316274014237 ABC-ATPase subunit interface; other site 316274014238 CHRD domain; Region: CHRD; cl06473 316274014239 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274014240 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274014241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274014242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274014243 active site 316274014244 ATP binding site [chemical binding]; other site 316274014245 substrate binding site [chemical binding]; other site 316274014246 activation loop (A-loop); other site 316274014247 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 316274014248 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 316274014249 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316274014250 active site 316274014251 DNA binding site [nucleotide binding] 316274014252 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 316274014253 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 316274014254 putative catalytic cysteine [active] 316274014255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274014256 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 316274014257 FAD binding site [chemical binding]; other site 316274014258 homotetramer interface [polypeptide binding]; other site 316274014259 substrate binding pocket [chemical binding]; other site 316274014260 catalytic base [active] 316274014261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014262 active site 316274014263 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 316274014264 phosphorylation site [posttranslational modification] 316274014265 intermolecular recognition site; other site 316274014266 dimerization interface [polypeptide binding]; other site 316274014267 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316274014268 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 316274014269 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 316274014270 ATP binding site [chemical binding]; other site 316274014271 Walker A motif; other site 316274014272 hexamer interface [polypeptide binding]; other site 316274014273 Walker B motif; other site 316274014274 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 316274014275 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316274014276 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 316274014277 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316274014278 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 316274014279 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 316274014280 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 316274014281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 316274014282 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316274014283 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 316274014284 RimM N-terminal domain; Region: RimM; pfam01782 316274014285 PRC-barrel domain; Region: PRC; pfam05239 316274014286 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 316274014287 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 316274014288 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 316274014289 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 316274014290 signal recognition particle protein; Provisional; Region: PRK10867 316274014291 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 316274014292 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316274014293 P loop; other site 316274014294 GTP binding site [chemical binding]; other site 316274014295 Signal peptide binding domain; Region: SRP_SPB; pfam02978 316274014296 Predicted membrane protein [Function unknown]; Region: COG2259 316274014297 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 316274014298 DNA gyrase subunit A; Validated; Region: PRK05560 316274014299 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 316274014300 CAP-like domain; other site 316274014301 active site 316274014302 primary dimer interface [polypeptide binding]; other site 316274014303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014304 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014305 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014306 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316274014309 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316274014310 active sites [active] 316274014311 tetramer interface [polypeptide binding]; other site 316274014312 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316274014313 active site 316274014314 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 316274014315 DinB superfamily; Region: DinB_2; pfam12867 316274014316 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 316274014317 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 316274014318 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 316274014319 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 316274014320 putative tRNA-binding site [nucleotide binding]; other site 316274014321 B3/4 domain; Region: B3_4; pfam03483 316274014322 tRNA synthetase B5 domain; Region: B5; pfam03484 316274014323 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 316274014324 dimer interface [polypeptide binding]; other site 316274014325 motif 1; other site 316274014326 motif 3; other site 316274014327 motif 2; other site 316274014328 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 316274014329 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 316274014330 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 316274014331 tetramer interface [polypeptide binding]; other site 316274014332 TPP-binding site [chemical binding]; other site 316274014333 heterodimer interface [polypeptide binding]; other site 316274014334 phosphorylation loop region [posttranslational modification] 316274014335 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 316274014336 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 316274014337 alpha subunit interface [polypeptide binding]; other site 316274014338 TPP binding site [chemical binding]; other site 316274014339 heterodimer interface [polypeptide binding]; other site 316274014340 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316274014341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316274014342 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 316274014343 E3 interaction surface; other site 316274014344 lipoyl attachment site [posttranslational modification]; other site 316274014345 e3 binding domain; Region: E3_binding; pfam02817 316274014346 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316274014347 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316274014348 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 316274014349 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316274014350 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 316274014351 23S rRNA binding site [nucleotide binding]; other site 316274014352 L21 binding site [polypeptide binding]; other site 316274014353 L13 binding site [polypeptide binding]; other site 316274014354 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 316274014355 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 316274014356 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 316274014357 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 316274014358 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274014359 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274014360 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274014361 active site 316274014362 catalytic site [active] 316274014363 uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914 316274014364 putative active site [active] 316274014365 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 316274014366 Catalytic site [active] 316274014367 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 316274014368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316274014369 FeS/SAM binding site; other site 316274014370 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 316274014371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274014372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014373 active site 316274014374 phosphorylation site [posttranslational modification] 316274014375 intermolecular recognition site; other site 316274014376 dimerization interface [polypeptide binding]; other site 316274014377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274014378 DNA binding residues [nucleotide binding] 316274014379 dimerization interface [polypeptide binding]; other site 316274014380 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014381 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014382 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274014383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274014384 putative active site [active] 316274014385 heme pocket [chemical binding]; other site 316274014386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014387 dimer interface [polypeptide binding]; other site 316274014388 phosphorylation site [posttranslational modification] 316274014389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014390 ATP binding site [chemical binding]; other site 316274014391 Mg2+ binding site [ion binding]; other site 316274014392 G-X-G motif; other site 316274014393 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 316274014394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274014395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274014396 DNA binding residues [nucleotide binding] 316274014397 Anti-sigma-K factor rskA; Region: RskA; pfam10099 316274014398 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 316274014399 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 316274014400 active site 316274014401 catalytic triad [active] 316274014402 Membrane protein of unknown function; Region: DUF360; pfam04020 316274014403 RDD family; Region: RDD; pfam06271 316274014404 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014405 GAF domain; Region: GAF; pfam01590 316274014406 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274014407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274014408 putative active site [active] 316274014409 heme pocket [chemical binding]; other site 316274014410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014411 dimer interface [polypeptide binding]; other site 316274014412 phosphorylation site [posttranslational modification] 316274014413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014414 ATP binding site [chemical binding]; other site 316274014415 Mg2+ binding site [ion binding]; other site 316274014416 G-X-G motif; other site 316274014417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274014418 dimerization interface [polypeptide binding]; other site 316274014419 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274014420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274014421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014422 dimer interface [polypeptide binding]; other site 316274014423 phosphorylation site [posttranslational modification] 316274014424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014425 ATP binding site [chemical binding]; other site 316274014426 Mg2+ binding site [ion binding]; other site 316274014427 G-X-G motif; other site 316274014428 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 316274014429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316274014430 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 316274014431 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 316274014432 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274014433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274014434 putative substrate translocation pore; other site 316274014435 Electron transfer DM13; Region: DM13; pfam10517 316274014436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316274014437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014438 active site 316274014439 phosphorylation site [posttranslational modification] 316274014440 intermolecular recognition site; other site 316274014441 dimerization interface [polypeptide binding]; other site 316274014442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316274014443 DNA binding site [nucleotide binding] 316274014444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014445 dimer interface [polypeptide binding]; other site 316274014446 phosphorylation site [posttranslational modification] 316274014447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014448 ATP binding site [chemical binding]; other site 316274014449 Mg2+ binding site [ion binding]; other site 316274014450 G-X-G motif; other site 316274014451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274014452 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 316274014453 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 316274014454 putative active site pocket [active] 316274014455 4-fold oligomerization interface [polypeptide binding]; other site 316274014456 metal binding residues [ion binding]; metal-binding site 316274014457 3-fold/trimer interface [polypeptide binding]; other site 316274014458 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 316274014459 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 316274014460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274014461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274014462 PspC domain; Region: PspC; pfam04024 316274014463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316274014464 putative DNA binding site [nucleotide binding]; other site 316274014465 dimerization interface [polypeptide binding]; other site 316274014466 putative Zn2+ binding site [ion binding]; other site 316274014467 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 316274014468 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316274014469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316274014470 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316274014471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316274014472 DNA binding residues [nucleotide binding] 316274014473 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316274014474 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 316274014475 putative [4Fe-4S] binding site [ion binding]; other site 316274014476 putative molybdopterin cofactor binding site [chemical binding]; other site 316274014477 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 316274014478 putative molybdopterin cofactor binding site; other site 316274014479 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 316274014480 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 316274014481 active site 316274014482 dimer interface [polypeptide binding]; other site 316274014483 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 316274014484 dimer interface [polypeptide binding]; other site 316274014485 active site 316274014486 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 316274014487 putative active site; other site 316274014488 putative metal binding residues [ion binding]; other site 316274014489 signature motif; other site 316274014490 putative triphosphate binding site [ion binding]; other site 316274014491 CHAD domain; Region: CHAD; pfam05235 316274014492 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 316274014493 putative RNAase interaction site [polypeptide binding]; other site 316274014494 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 316274014495 active site 316274014496 barstar interaction site; other site 316274014497 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 316274014498 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 316274014499 putative ligand binding site [chemical binding]; other site 316274014500 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316274014501 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 316274014502 active site 316274014503 Zn binding site [ion binding]; other site 316274014504 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 316274014505 peptide binding site [polypeptide binding]; other site 316274014506 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316274014507 dimer interface [polypeptide binding]; other site 316274014508 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 316274014509 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 316274014510 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274014511 Zn2+ binding site [ion binding]; other site 316274014512 Mg2+ binding site [ion binding]; other site 316274014513 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 316274014514 YacP-like NYN domain; Region: NYN_YacP; cl01491 316274014515 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 316274014516 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 316274014517 homotetramer interface [polypeptide binding]; other site 316274014518 FMN binding site [chemical binding]; other site 316274014519 homodimer contacts [polypeptide binding]; other site 316274014520 putative active site [active] 316274014521 putative substrate binding site [chemical binding]; other site 316274014522 putative acetyltransferase YhhY; Provisional; Region: PRK10140 316274014523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274014524 Coenzyme A binding pocket [chemical binding]; other site 316274014525 Transglycosylase; Region: Transgly; pfam00912 316274014526 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 316274014527 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316274014528 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 316274014529 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274014530 GTP-binding protein YchF; Reviewed; Region: PRK09601 316274014531 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274014532 G1 box; other site 316274014533 GTP/Mg2+ binding site [chemical binding]; other site 316274014534 G2 box; other site 316274014535 Switch I region; other site 316274014536 G3 box; other site 316274014537 Switch II region; other site 316274014538 G4 box; other site 316274014539 G5 box; other site 316274014540 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 316274014541 Leucine rich repeat; Region: LRR_8; pfam13855 316274014542 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274014543 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 316274014544 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 316274014545 active site 316274014546 substrate binding site [chemical binding]; other site 316274014547 metal binding site [ion binding]; metal-binding site 316274014548 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 316274014549 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 316274014550 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 316274014551 active site 316274014552 Int/Topo IB signature motif; other site 316274014553 glycyl-tRNA synthetase; Provisional; Region: PRK04173 316274014554 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 316274014555 dimer interface [polypeptide binding]; other site 316274014556 motif 1; other site 316274014557 active site 316274014558 motif 2; other site 316274014559 motif 3; other site 316274014560 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 316274014561 anticodon binding site; other site 316274014562 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274014563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274014564 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 316274014565 NAD(P) binding site [chemical binding]; other site 316274014566 active site 316274014567 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 316274014568 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316274014569 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316274014570 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 316274014571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274014572 sequence-specific DNA binding site [nucleotide binding]; other site 316274014573 salt bridge; other site 316274014574 AAA ATPase domain; Region: AAA_16; pfam13191 316274014575 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 316274014576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274014577 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 316274014578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 316274014579 FeS/SAM binding site; other site 316274014580 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316274014581 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316274014582 Walker A/P-loop; other site 316274014583 ATP binding site [chemical binding]; other site 316274014584 Q-loop/lid; other site 316274014585 ABC transporter signature motif; other site 316274014586 Walker B; other site 316274014587 D-loop; other site 316274014588 H-loop/switch region; other site 316274014589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274014590 Histidine kinase; Region: HisKA_3; pfam07730 316274014591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316274014592 ATP binding site [chemical binding]; other site 316274014593 Mg2+ binding site [ion binding]; other site 316274014594 G-X-G motif; other site 316274014595 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 316274014596 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 316274014597 RNA/DNA hybrid binding site [nucleotide binding]; other site 316274014598 active site 316274014599 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 316274014600 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 316274014601 catalytic triad [active] 316274014602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274014603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274014604 DNA binding site [nucleotide binding] 316274014605 domain linker motif; other site 316274014606 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 316274014607 putative dimerization interface [polypeptide binding]; other site 316274014608 putative ligand binding site [chemical binding]; other site 316274014609 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316274014610 active site 316274014611 phosphorylation site [posttranslational modification] 316274014612 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316274014613 dimerization domain swap beta strand [polypeptide binding]; other site 316274014614 regulatory protein interface [polypeptide binding]; other site 316274014615 active site 316274014616 regulatory phosphorylation site [posttranslational modification]; other site 316274014617 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 316274014618 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316274014619 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316274014620 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316274014621 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 316274014622 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 316274014623 putative substrate binding site [chemical binding]; other site 316274014624 putative ATP binding site [chemical binding]; other site 316274014625 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 316274014626 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316274014627 active site 316274014628 P-loop; other site 316274014629 phosphorylation site [posttranslational modification] 316274014630 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 316274014631 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316274014632 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274014633 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 316274014634 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 316274014635 ligand binding site; other site 316274014636 oligomer interface; other site 316274014637 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 316274014638 dimer interface [polypeptide binding]; other site 316274014639 N-terminal domain interface [polypeptide binding]; other site 316274014640 sulfate 1 binding site; other site 316274014641 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 316274014642 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 316274014643 ligand binding site; other site 316274014644 oligomer interface; other site 316274014645 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 316274014646 dimer interface [polypeptide binding]; other site 316274014647 N-terminal domain interface [polypeptide binding]; other site 316274014648 sulfate 1 binding site; other site 316274014649 metal-dependent hydrolase; Provisional; Region: PRK13291 316274014650 DinB superfamily; Region: DinB_2; pfam12867 316274014651 DinB superfamily; Region: DinB_2; pfam12867 316274014652 metal-dependent hydrolase; Provisional; Region: PRK13291 316274014653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274014654 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 316274014655 ABC1 family; Region: ABC1; cl17513 316274014656 ABC1 family; Region: ABC1; cl17513 316274014657 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 316274014658 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274014659 catalytic triad [active] 316274014660 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 316274014661 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316274014662 catalytic triad [active] 316274014663 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 316274014664 AAA ATPase domain; Region: AAA_16; pfam13191 316274014665 Predicted ATPase [General function prediction only]; Region: COG3899 316274014666 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316274014667 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316274014668 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 316274014669 active site 316274014670 elongation factor P; Validated; Region: PRK00529 316274014671 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316274014672 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 316274014673 RNA binding site [nucleotide binding]; other site 316274014674 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 316274014675 RNA binding site [nucleotide binding]; other site 316274014676 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 316274014677 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316274014678 carboxyltransferase (CT) interaction site; other site 316274014679 biotinylation site [posttranslational modification]; other site 316274014680 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 316274014681 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 316274014682 generic binding surface II; other site 316274014683 generic binding surface I; other site 316274014684 Predicted ATPase [General function prediction only]; Region: COG3910 316274014685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274014686 Walker A/P-loop; other site 316274014687 ATP binding site [chemical binding]; other site 316274014688 Q-loop/lid; other site 316274014689 ABC transporter signature motif; other site 316274014690 Walker B; other site 316274014691 D-loop; other site 316274014692 H-loop/switch region; other site 316274014693 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 316274014694 FAD binding pocket [chemical binding]; other site 316274014695 FAD binding motif [chemical binding]; other site 316274014696 phosphate binding motif [ion binding]; other site 316274014697 beta-alpha-beta structure motif; other site 316274014698 NAD binding pocket [chemical binding]; other site 316274014699 Iron coordination center [ion binding]; other site 316274014700 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 316274014701 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 316274014702 Glutamate binding site [chemical binding]; other site 316274014703 homodimer interface [polypeptide binding]; other site 316274014704 NAD binding site [chemical binding]; other site 316274014705 catalytic residues [active] 316274014706 Response regulator receiver domain; Region: Response_reg; pfam00072 316274014707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014708 active site 316274014709 phosphorylation site [posttranslational modification] 316274014710 intermolecular recognition site; other site 316274014711 dimerization interface [polypeptide binding]; other site 316274014712 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274014713 nudix motif; other site 316274014714 Transposase IS200 like; Region: Y1_Tnp; pfam01797 316274014715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 316274014716 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 316274014717 Probable transposase; Region: OrfB_IS605; pfam01385 316274014718 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 316274014719 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 316274014720 putative FMN binding site [chemical binding]; other site 316274014721 DinB family; Region: DinB; cl17821 316274014722 Protein of unknown function (DUF402); Region: DUF402; cl00979 316274014723 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316274014724 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274014725 Probable Catalytic site; other site 316274014726 metal-binding site 316274014727 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 316274014728 Uncharacterized conserved protein [Function unknown]; Region: COG1543 316274014729 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 316274014730 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 316274014731 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274014732 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316274014733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274014734 S-adenosylmethionine binding site [chemical binding]; other site 316274014735 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 316274014736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274014737 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316274014738 oligoendopeptidase F; Region: pepF; TIGR00181 316274014739 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 316274014740 active site 316274014741 Zn binding site [ion binding]; other site 316274014742 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 316274014743 active site 316274014744 putative DNA-binding cleft [nucleotide binding]; other site 316274014745 dimer interface [polypeptide binding]; other site 316274014746 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 316274014747 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 316274014748 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274014749 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274014750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274014751 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274014752 active site 316274014753 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 316274014754 Aspartase; Region: Aspartase; cd01357 316274014755 active sites [active] 316274014756 tetramer interface [polypeptide binding]; other site 316274014757 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 316274014758 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 316274014759 nad+ binding pocket [chemical binding]; other site 316274014760 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 316274014761 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316274014762 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316274014763 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316274014764 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 316274014765 active site 316274014766 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316274014767 dimer interface [polypeptide binding]; other site 316274014768 substrate binding site [chemical binding]; other site 316274014769 catalytic residues [active] 316274014770 ATP cone domain; Region: ATP-cone; pfam03477 316274014771 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 316274014772 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 316274014773 GAF domain; Region: GAF_3; pfam13492 316274014774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274014775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274014776 dimer interface [polypeptide binding]; other site 316274014777 phosphorylation site [posttranslational modification] 316274014778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274014779 ATP binding site [chemical binding]; other site 316274014780 Mg2+ binding site [ion binding]; other site 316274014781 G-X-G motif; other site 316274014782 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014783 GAF domain; Region: GAF_2; pfam13185 316274014784 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014785 GAF domain; Region: GAF_3; pfam13492 316274014786 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014787 GAF domain; Region: GAF; pfam01590 316274014788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014789 GAF domain; Region: GAF; pfam01590 316274014790 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014791 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014793 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014794 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274014795 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316274014796 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316274014797 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316274014798 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 316274014799 intersubunit interface [polypeptide binding]; other site 316274014800 active site 316274014801 Zn2+ binding site [ion binding]; other site 316274014802 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274014803 cytokinin dehydrogenase; Region: PLN02441 316274014804 FAD binding domain; Region: FAD_binding_4; pfam01565 316274014805 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 316274014806 Predicted amidohydrolase [General function prediction only]; Region: COG0388 316274014807 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 316274014808 putative active site [active] 316274014809 catalytic triad [active] 316274014810 putative dimer interface [polypeptide binding]; other site 316274014811 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316274014812 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316274014813 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274014814 rod shape-determining protein MreC; Region: MreC; pfam04085 316274014815 rod shape-determining protein MreB; Provisional; Region: PRK13927 316274014816 MreB and similar proteins; Region: MreB_like; cd10225 316274014817 nucleotide binding site [chemical binding]; other site 316274014818 Mg binding site [ion binding]; other site 316274014819 putative protofilament interaction site [polypeptide binding]; other site 316274014820 RodZ interaction site [polypeptide binding]; other site 316274014821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274014822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274014823 active site 316274014824 phosphorylation site [posttranslational modification] 316274014825 intermolecular recognition site; other site 316274014826 dimerization interface [polypeptide binding]; other site 316274014827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274014828 DNA binding residues [nucleotide binding] 316274014829 dimerization interface [polypeptide binding]; other site 316274014830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274014831 H+ Antiporter protein; Region: 2A0121; TIGR00900 316274014832 putative substrate translocation pore; other site 316274014833 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316274014834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274014835 S-adenosylmethionine binding site [chemical binding]; other site 316274014836 HNH endonuclease; Region: HNH_2; pfam13391 316274014837 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 316274014838 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316274014839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274014840 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 316274014841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274014842 active site 316274014843 metal binding site [ion binding]; metal-binding site 316274014844 HEAT repeats; Region: HEAT_2; pfam13646 316274014845 HEAT repeat; Region: HEAT; pfam02985 316274014846 HEAT repeats; Region: HEAT_2; pfam13646 316274014847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274014848 Phosphotransferase enzyme family; Region: APH; pfam01636 316274014849 active site 316274014850 ATP binding site [chemical binding]; other site 316274014851 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274014852 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 316274014853 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 316274014854 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274014855 putative active site [active] 316274014856 putative NTP binding site [chemical binding]; other site 316274014857 putative nucleic acid binding site [nucleotide binding]; other site 316274014858 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274014859 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274014860 active site 316274014861 ribonuclease Y; Region: RNase_Y; TIGR03319 316274014862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316274014863 Zn2+ binding site [ion binding]; other site 316274014864 Mg2+ binding site [ion binding]; other site 316274014865 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 316274014866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274014867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274014868 active site 316274014869 ATP binding site [chemical binding]; other site 316274014870 substrate binding site [chemical binding]; other site 316274014871 activation loop (A-loop); other site 316274014872 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316274014873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316274014874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316274014875 DNA binding site [nucleotide binding] 316274014876 domain linker motif; other site 316274014877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 316274014878 ligand binding site [chemical binding]; other site 316274014879 dimerization interface [polypeptide binding]; other site 316274014880 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316274014881 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 316274014882 putative substrate binding site [chemical binding]; other site 316274014883 putative ATP binding site [chemical binding]; other site 316274014884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316274014885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316274014886 putative substrate translocation pore; other site 316274014887 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 316274014888 active site 316274014889 oxyanion hole [active] 316274014890 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274014891 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274014892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274014893 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274014894 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316274014895 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316274014896 active site 316274014897 metal binding site [ion binding]; metal-binding site 316274014898 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 316274014899 Cellulose binding domain; Region: CBM_2; pfam00553 316274014900 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 316274014901 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274014902 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274014903 ParB-like nuclease domain; Region: ParB; smart00470 316274014904 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 316274014905 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274014906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316274014907 P-loop; other site 316274014908 Magnesium ion binding site [ion binding]; other site 316274014909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316274014910 Magnesium ion binding site [ion binding]; other site 316274014911 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 316274014912 MPT binding site; other site 316274014913 trimer interface [polypeptide binding]; other site 316274014914 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316274014915 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316274014916 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 316274014917 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 316274014918 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 316274014919 dimerization interface [polypeptide binding]; other site 316274014920 DPS ferroxidase diiron center [ion binding]; other site 316274014921 ion pore; other site 316274014922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316274014923 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 316274014924 putative metal binding site; other site 316274014925 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316274014926 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316274014927 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 316274014928 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316274014929 nudix motif; other site 316274014930 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316274014931 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316274014932 NADP-binding site; other site 316274014933 homotetramer interface [polypeptide binding]; other site 316274014934 substrate binding site [chemical binding]; other site 316274014935 homodimer interface [polypeptide binding]; other site 316274014936 active site 316274014937 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 316274014938 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 316274014939 Substrate binding site; other site 316274014940 Cupin domain; Region: Cupin_2; cl17218 316274014941 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 316274014942 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316274014943 active site 316274014944 Substrate binding site; other site 316274014945 Mg++ binding site; other site 316274014946 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316274014947 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316274014948 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 316274014949 active site 316274014950 substrate binding site [chemical binding]; other site 316274014951 metal binding site [ion binding]; metal-binding site 316274014952 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 316274014953 dimer interface [polypeptide binding]; other site 316274014954 FMN binding site [chemical binding]; other site 316274014955 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 316274014956 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 316274014957 Flavoprotein; Region: Flavoprotein; pfam02441 316274014958 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 316274014959 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 316274014960 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 316274014961 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 316274014962 protein binding site [polypeptide binding]; other site 316274014963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274014964 non-specific DNA binding site [nucleotide binding]; other site 316274014965 salt bridge; other site 316274014966 sequence-specific DNA binding site [nucleotide binding]; other site 316274014967 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274014968 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 316274014969 carboxylate-amine ligase; Provisional; Region: PRK13515 316274014970 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 316274014971 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 316274014972 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 316274014973 putative active site [active] 316274014974 substrate binding site [chemical binding]; other site 316274014975 putative cosubstrate binding site; other site 316274014976 catalytic site [active] 316274014977 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 316274014978 substrate binding site [chemical binding]; other site 316274014979 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 316274014980 DHH family; Region: DHH; pfam01368 316274014981 DHHA1 domain; Region: DHHA1; pfam02272 316274014982 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 316274014983 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 316274014984 ATP binding site [chemical binding]; other site 316274014985 active site 316274014986 substrate binding site [chemical binding]; other site 316274014987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274014988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274014989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316274014990 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 316274014991 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 316274014992 putative active site [active] 316274014993 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316274014994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316274014995 P-loop; other site 316274014996 Magnesium ion binding site [ion binding]; other site 316274014997 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316274014998 Magnesium ion binding site [ion binding]; other site 316274014999 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 316274015000 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 316274015001 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 316274015002 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274015003 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 316274015004 Phosphoglycerate kinase; Region: PGK; pfam00162 316274015005 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 316274015006 substrate binding site [chemical binding]; other site 316274015007 hinge regions; other site 316274015008 ADP binding site [chemical binding]; other site 316274015009 catalytic site [active] 316274015010 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 316274015011 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 316274015012 GAF domain; Region: GAF_3; pfam13492 316274015013 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274015014 GAF domain; Region: GAF; pfam01590 316274015015 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316274015016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274015017 putative active site [active] 316274015018 heme pocket [chemical binding]; other site 316274015019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274015020 dimer interface [polypeptide binding]; other site 316274015021 phosphorylation site [posttranslational modification] 316274015022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015023 ATP binding site [chemical binding]; other site 316274015024 Mg2+ binding site [ion binding]; other site 316274015025 G-X-G motif; other site 316274015026 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274015027 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 316274015028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015029 ATP binding site [chemical binding]; other site 316274015030 Mg2+ binding site [ion binding]; other site 316274015031 G-X-G motif; other site 316274015032 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 316274015033 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 316274015034 dimerization interface [polypeptide binding]; other site 316274015035 putative ATP binding site [chemical binding]; other site 316274015036 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 316274015037 Right handed beta helix region; Region: Beta_helix; pfam13229 316274015038 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 316274015039 agmatinase; Region: agmatinase; TIGR01230 316274015040 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 316274015041 putative active site [active] 316274015042 Mn binding site [ion binding]; other site 316274015043 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274015044 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 316274015045 trimer interface [polypeptide binding]; other site 316274015046 dimer interface [polypeptide binding]; other site 316274015047 putative active site [active] 316274015048 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 316274015049 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 316274015050 active site 316274015051 nucleophile elbow; other site 316274015052 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 316274015053 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 316274015054 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 316274015055 PspC domain; Region: PspC; pfam04024 316274015056 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 316274015057 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 316274015058 active site 316274015059 putative substrate binding pocket [chemical binding]; other site 316274015060 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 316274015061 putative active site; other site 316274015062 putative metal binding residues [ion binding]; other site 316274015063 signature motif; other site 316274015064 putative triphosphate binding site [ion binding]; other site 316274015065 Uncharacterized conserved protein [Function unknown]; Region: COG1434 316274015066 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316274015067 putative active site [active] 316274015068 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 316274015069 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 316274015070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274015071 Coenzyme A binding pocket [chemical binding]; other site 316274015072 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 316274015073 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316274015074 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 316274015075 dimer interface [polypeptide binding]; other site 316274015076 motif 1; other site 316274015077 active site 316274015078 motif 2; other site 316274015079 YbaK / prolyl-tRNA synthetases associated domain; Region: YbaK; pfam04073 316274015080 putative deacylase active site [active] 316274015081 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316274015082 active site 316274015083 motif 3; other site 316274015084 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 316274015085 anticodon binding site; other site 316274015086 Protein of unknown function (DUF328); Region: DUF328; cl01143 316274015087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 316274015088 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 316274015089 substrate binding pocket [chemical binding]; other site 316274015090 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 316274015091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274015092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274015093 phosphorylation site [posttranslational modification] 316274015094 dimer interface [polypeptide binding]; other site 316274015095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015096 ATP binding site [chemical binding]; other site 316274015097 Mg2+ binding site [ion binding]; other site 316274015098 G-X-G motif; other site 316274015099 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 316274015100 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316274015101 ATP binding site [chemical binding]; other site 316274015102 substrate interface [chemical binding]; other site 316274015103 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 316274015104 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 316274015105 Mg++ binding site [ion binding]; other site 316274015106 putative catalytic motif [active] 316274015107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274015108 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274015109 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 316274015110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316274015111 motif II; other site 316274015112 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 316274015113 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316274015114 Zn binding site [ion binding]; other site 316274015115 Integral membrane protein DUF92; Region: DUF92; pfam01940 316274015116 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 316274015117 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 316274015118 oligomer interface [polypeptide binding]; other site 316274015119 active site 316274015120 metal binding site [ion binding]; metal-binding site 316274015121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274015122 S-adenosylmethionine binding site [chemical binding]; other site 316274015123 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 316274015124 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 316274015125 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 316274015126 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 316274015127 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 316274015128 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 316274015129 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 316274015130 MutS domain III; Region: MutS_III; pfam05192 316274015131 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 316274015132 Walker A/P-loop; other site 316274015133 ATP binding site [chemical binding]; other site 316274015134 Q-loop/lid; other site 316274015135 ABC transporter signature motif; other site 316274015136 Walker B; other site 316274015137 D-loop; other site 316274015138 H-loop/switch region; other site 316274015139 Smr domain; Region: Smr; pfam01713 316274015140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274015141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015142 ATP binding site [chemical binding]; other site 316274015143 Mg2+ binding site [ion binding]; other site 316274015144 G-X-G motif; other site 316274015145 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 316274015146 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 316274015147 Substrate-binding site [chemical binding]; other site 316274015148 Substrate specificity [chemical binding]; other site 316274015149 Uncharacterized conserved protein [Function unknown]; Region: COG1284 316274015150 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274015151 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 316274015152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274015153 Histidine kinase; Region: HisKA_3; pfam07730 316274015154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015155 ATP binding site [chemical binding]; other site 316274015156 Mg2+ binding site [ion binding]; other site 316274015157 G-X-G motif; other site 316274015158 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 316274015159 putative catalytic residues [active] 316274015160 TPR repeat; Region: TPR_11; pfam13414 316274015161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015162 TPR motif; other site 316274015163 binding surface 316274015164 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316274015165 von Willebrand factor type A domain; Region: VWA_2; pfam13519 316274015166 metal ion-dependent adhesion site (MIDAS); other site 316274015167 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 316274015168 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 316274015169 metal ion-dependent adhesion site (MIDAS); other site 316274015170 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316274015171 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316274015172 metal ion-dependent adhesion site (MIDAS); other site 316274015173 MoxR-like ATPases [General function prediction only]; Region: COG0714 316274015174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274015175 Walker A motif; other site 316274015176 ATP binding site [chemical binding]; other site 316274015177 Walker B motif; other site 316274015178 arginine finger; other site 316274015179 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 316274015180 PBP superfamily domain; Region: PBP_like_2; cl17296 316274015181 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 316274015182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274015183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316274015184 dimerization interface [polypeptide binding]; other site 316274015185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316274015186 dimer interface [polypeptide binding]; other site 316274015187 phosphorylation site [posttranslational modification] 316274015188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015189 ATP binding site [chemical binding]; other site 316274015190 Mg2+ binding site [ion binding]; other site 316274015191 G-X-G motif; other site 316274015192 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274015193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274015194 active site 316274015195 phosphorylation site [posttranslational modification] 316274015196 intermolecular recognition site; other site 316274015197 dimerization interface [polypeptide binding]; other site 316274015198 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316274015199 Sensor protein DegS; Region: DegS; pfam05384 316274015200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274015201 Histidine kinase; Region: HisKA_3; pfam07730 316274015202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015203 ATP binding site [chemical binding]; other site 316274015204 Mg2+ binding site [ion binding]; other site 316274015205 G-X-G motif; other site 316274015206 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 316274015207 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316274015208 dimer interface [polypeptide binding]; other site 316274015209 active site 316274015210 Protein of unknown function DUF72; Region: DUF72; pfam01904 316274015211 elongation factor Tu; Reviewed; Region: PRK00049 316274015212 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 316274015213 G1 box; other site 316274015214 GEF interaction site [polypeptide binding]; other site 316274015215 GTP/Mg2+ binding site [chemical binding]; other site 316274015216 Switch I region; other site 316274015217 G2 box; other site 316274015218 G3 box; other site 316274015219 Switch II region; other site 316274015220 G4 box; other site 316274015221 G5 box; other site 316274015222 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316274015223 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 316274015224 Antibiotic Binding Site [chemical binding]; other site 316274015225 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 316274015226 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 316274015227 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 316274015228 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 316274015229 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 316274015230 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 316274015231 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 316274015232 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 316274015233 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 316274015234 putative translocon binding site; other site 316274015235 protein-rRNA interface [nucleotide binding]; other site 316274015236 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 316274015237 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 316274015238 G-X-X-G motif; other site 316274015239 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 316274015240 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 316274015241 23S rRNA interface [nucleotide binding]; other site 316274015242 5S rRNA interface [nucleotide binding]; other site 316274015243 putative antibiotic binding site [chemical binding]; other site 316274015244 L25 interface [polypeptide binding]; other site 316274015245 L27 interface [polypeptide binding]; other site 316274015246 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 316274015247 23S rRNA interface [nucleotide binding]; other site 316274015248 putative translocon interaction site; other site 316274015249 signal recognition particle (SRP54) interaction site; other site 316274015250 L23 interface [polypeptide binding]; other site 316274015251 trigger factor interaction site; other site 316274015252 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 316274015253 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 316274015254 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 316274015255 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 316274015256 RNA binding site [nucleotide binding]; other site 316274015257 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 316274015258 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 316274015259 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 316274015260 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 316274015261 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 316274015262 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 316274015263 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316274015264 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316274015265 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 316274015266 23S rRNA interface [nucleotide binding]; other site 316274015267 5S rRNA interface [nucleotide binding]; other site 316274015268 L27 interface [polypeptide binding]; other site 316274015269 L5 interface [polypeptide binding]; other site 316274015270 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 316274015271 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 316274015272 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 316274015273 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 316274015274 23S rRNA binding site [nucleotide binding]; other site 316274015275 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 316274015276 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 316274015277 SecY translocase; Region: SecY; pfam00344 316274015278 adenylate kinase; Reviewed; Region: adk; PRK00279 316274015279 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316274015280 AMP-binding site [chemical binding]; other site 316274015281 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316274015282 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 316274015283 rRNA binding site [nucleotide binding]; other site 316274015284 predicted 30S ribosome binding site; other site 316274015285 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 316274015286 30S ribosomal protein S13; Region: bact_S13; TIGR03631 316274015287 30S ribosomal protein S11; Validated; Region: PRK05309 316274015288 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 316274015289 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 316274015290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316274015291 RNA binding surface [nucleotide binding]; other site 316274015292 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 316274015293 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 316274015294 alphaNTD homodimer interface [polypeptide binding]; other site 316274015295 alphaNTD - beta interaction site [polypeptide binding]; other site 316274015296 alphaNTD - beta' interaction site [polypeptide binding]; other site 316274015297 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 316274015298 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 316274015299 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 316274015300 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 316274015301 dimerization interface 3.5A [polypeptide binding]; other site 316274015302 active site 316274015303 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 316274015304 23S rRNA interface [nucleotide binding]; other site 316274015305 L3 interface [polypeptide binding]; other site 316274015306 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 316274015307 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316274015308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274015309 Walker A/P-loop; other site 316274015310 ATP binding site [chemical binding]; other site 316274015311 Q-loop/lid; other site 316274015312 ABC transporter signature motif; other site 316274015313 Walker B; other site 316274015314 D-loop; other site 316274015315 H-loop/switch region; other site 316274015316 ABC transporter; Region: ABC_tran_2; pfam12848 316274015317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316274015318 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 316274015319 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274015320 Predicted membrane protein [Function unknown]; Region: COG2364 316274015321 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316274015322 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 316274015323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316274015324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316274015325 protein binding site [polypeptide binding]; other site 316274015326 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 316274015327 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 316274015328 metal binding site [ion binding]; metal-binding site 316274015329 dimer interface [polypeptide binding]; other site 316274015330 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316274015331 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274015332 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274015333 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274015334 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274015335 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 316274015336 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274015337 Calx-beta domain; Region: Calx-beta; pfam03160 316274015338 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274015339 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274015340 Phage Tail Collar Domain; Region: Collar; pfam07484 316274015341 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274015342 Phage Tail Collar Domain; Region: Collar; pfam07484 316274015343 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316274015344 Phage Tail Collar Domain; Region: Collar; pfam07484 316274015345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316274015346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316274015347 Coenzyme A binding pocket [chemical binding]; other site 316274015348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316274015349 ribosome recycling factor; Reviewed; Region: frr; PRK00083 316274015350 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 316274015351 hinge region; other site 316274015352 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 316274015353 putative nucleotide binding site [chemical binding]; other site 316274015354 uridine monophosphate binding site [chemical binding]; other site 316274015355 homohexameric interface [polypeptide binding]; other site 316274015356 elongation factor Ts; Reviewed; Region: tsf; PRK12332 316274015357 UBA/TS-N domain; Region: UBA; pfam00627 316274015358 Elongation factor TS; Region: EF_TS; pfam00889 316274015359 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 316274015360 rRNA interaction site [nucleotide binding]; other site 316274015361 S8 interaction site; other site 316274015362 putative laminin-1 binding site; other site 316274015363 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 316274015364 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316274015365 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274015366 dimer interface [polypeptide binding]; other site 316274015367 ssDNA binding site [nucleotide binding]; other site 316274015368 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274015369 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 316274015370 excinuclease ABC subunit B; Provisional; Region: PRK05298 316274015371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274015372 ATP binding site [chemical binding]; other site 316274015373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274015374 nucleotide binding region [chemical binding]; other site 316274015375 ATP-binding site [chemical binding]; other site 316274015376 Ultra-violet resistance protein B; Region: UvrB; pfam12344 316274015377 UvrB/uvrC motif; Region: UVR; pfam02151 316274015378 helicase 45; Provisional; Region: PTZ00424 316274015379 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316274015380 ATP binding site [chemical binding]; other site 316274015381 Mg++ binding site [ion binding]; other site 316274015382 motif III; other site 316274015383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274015384 nucleotide binding region [chemical binding]; other site 316274015385 ATP-binding site [chemical binding]; other site 316274015386 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 316274015387 RNA binding site [nucleotide binding]; other site 316274015388 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 316274015389 active site 316274015390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316274015391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015392 ATP binding site [chemical binding]; other site 316274015393 Mg2+ binding site [ion binding]; other site 316274015394 G-X-G motif; other site 316274015395 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 316274015396 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316274015397 Clp amino terminal domain; Region: Clp_N; pfam02861 316274015398 Clp amino terminal domain; Region: Clp_N; pfam02861 316274015399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274015400 Walker A motif; other site 316274015401 ATP binding site [chemical binding]; other site 316274015402 Walker B motif; other site 316274015403 arginine finger; other site 316274015404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274015405 Walker A motif; other site 316274015406 ATP binding site [chemical binding]; other site 316274015407 Walker B motif; other site 316274015408 arginine finger; other site 316274015409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316274015410 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 316274015411 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 316274015412 Glycoprotease family; Region: Peptidase_M22; pfam00814 316274015413 topology modulation protein; Reviewed; Region: PRK08118 316274015414 AAA domain; Region: AAA_17; pfam13207 316274015415 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 316274015416 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274015417 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274015418 phosphopeptide binding site; other site 316274015419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316274015420 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 316274015421 phosphopeptide binding site; other site 316274015422 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 316274015423 NADH dehydrogenase subunit B; Provisional; Region: PRK14819 316274015424 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 316274015425 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 316274015426 NADH dehydrogenase subunit D; Validated; Region: PRK06075 316274015427 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 316274015428 4Fe-4S binding domain; Region: Fer4; pfam00037 316274015429 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 316274015430 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 316274015431 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 316274015432 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 316274015433 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 316274015434 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316274015435 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274015436 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274015437 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274015438 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316274015439 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274015440 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316274015441 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316274015442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316274015443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316274015444 active site 316274015445 ATP binding site [chemical binding]; other site 316274015446 substrate binding site [chemical binding]; other site 316274015447 activation loop (A-loop); other site 316274015448 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 316274015449 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 316274015450 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 316274015451 active site 316274015452 PspC domain; Region: PspC; pfam04024 316274015453 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316274015454 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316274015455 putative RNA binding site [nucleotide binding]; other site 316274015456 Calx-beta domain; Region: Calx-beta; cl02522 316274015457 Calx-beta domain; Region: Calx-beta; pfam03160 316274015458 Calx-beta domain; Region: Calx-beta; cl02522 316274015459 Calx-beta domain; Region: Calx-beta; cl02522 316274015460 Calx-beta domain; Region: Calx-beta; cl02522 316274015461 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316274015462 MPN+ (JAMM) motif; other site 316274015463 Zinc-binding site [ion binding]; other site 316274015464 Uncharacterized conserved protein [Function unknown]; Region: COG4715 316274015465 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 316274015466 putative active site [active] 316274015467 putative catalytic site [active] 316274015468 putative Mg binding site IVb [ion binding]; other site 316274015469 putative phosphate binding site [ion binding]; other site 316274015470 putative DNA binding site [nucleotide binding]; other site 316274015471 putative Mg binding site IVa [ion binding]; other site 316274015472 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 316274015473 potassium uptake protein; Region: kup; TIGR00794 316274015474 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274015475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316274015476 nucleotide binding site [chemical binding]; other site 316274015477 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 316274015478 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 316274015479 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 316274015480 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 316274015481 DNA binding residues [nucleotide binding] 316274015482 drug binding residues [chemical binding]; other site 316274015483 dimer interface [polypeptide binding]; other site 316274015484 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 316274015485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316274015486 Uncharacterized conserved protein [Function unknown]; Region: COG2442 316274015487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274015488 non-specific DNA binding site [nucleotide binding]; other site 316274015489 salt bridge; other site 316274015490 sequence-specific DNA binding site [nucleotide binding]; other site 316274015491 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274015492 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 316274015493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316274015494 Integrase core domain; Region: rve; pfam00665 316274015495 Integrase core domain; Region: rve_3; pfam13683 316274015496 Homeodomain-like domain; Region: HTH_23; pfam13384 316274015497 Winged helix-turn helix; Region: HTH_29; pfam13551 316274015498 Homeodomain-like domain; Region: HTH_32; pfam13565 316274015499 Integrase core domain; Region: rve; pfam00665 316274015500 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274015501 CARDB; Region: CARDB; pfam07705 316274015502 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 316274015503 Cupin domain; Region: Cupin_2; pfam07883 316274015504 glycosyltransferase, MGT family; Region: MGT; TIGR01426 316274015505 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 316274015506 active site 316274015507 TDP-binding site; other site 316274015508 acceptor substrate-binding pocket; other site 316274015509 homodimer interface [polypeptide binding]; other site 316274015510 Bacterial transcriptional activator domain; Region: BTAD; smart01043 316274015511 AAA ATPase domain; Region: AAA_16; pfam13191 316274015512 Predicted ATPase [General function prediction only]; Region: COG3903 316274015513 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274015514 Transposase domain (DUF772); Region: DUF772; pfam05598 316274015515 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 316274015516 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 316274015517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 316274015518 Transposase; Region: DDE_Tnp_ISL3; pfam01610 316274015519 Helix-turn-helix domain; Region: HTH_38; pfam13936 316274015520 DNA-binding interface [nucleotide binding]; DNA binding site 316274015521 Transposase; Region: DDE_Tnp_ISL3; pfam01610 316274015522 MULE transposase domain; Region: MULE; pfam10551 316274015523 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274015524 rod shape-determining protein MreC; Provisional; Region: PRK13922 316274015525 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 316274015526 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316274015527 active site 316274015528 ATP binding site [chemical binding]; other site 316274015529 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316274015530 Putative transposase; Region: Y2_Tnp; pfam04986 316274015531 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274015532 active site 316274015533 DNA binding site [nucleotide binding] 316274015534 Int/Topo IB signature motif; other site 316274015535 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 316274015536 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 316274015537 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 316274015538 active site 316274015539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274015540 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274015541 Winged helix-turn helix; Region: HTH_29; pfam13551 316274015542 Integrase core domain; Region: rve; pfam00665 316274015543 Integrase core domain; Region: rve_3; pfam13683 316274015544 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 316274015545 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 316274015546 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316274015547 oligomeric interface; other site 316274015548 putative active site [active] 316274015549 homodimer interface [polypeptide binding]; other site 316274015550 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274015552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274015553 DNA binding residues [nucleotide binding] 316274015554 Winged helix-turn helix; Region: HTH_29; pfam13551 316274015555 Homeodomain-like domain; Region: HTH_32; pfam13565 316274015556 Integrase core domain; Region: rve; pfam00665 316274015557 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015558 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015559 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 316274015560 active site 316274015561 catalytic site [active] 316274015562 Apolipoprotein M (ApoM); Region: ApoM; pfam11032 316274015563 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274015564 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316274015565 Domain of unknown function DUF11; Region: DUF11; pfam01345 316274015566 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 316274015567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274015568 CAAX protease self-immunity; Region: Abi; pfam02517 316274015569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274015570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015571 ATP binding site [chemical binding]; other site 316274015572 Mg2+ binding site [ion binding]; other site 316274015573 G-X-G motif; other site 316274015574 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 316274015575 substrate binding pocket [chemical binding]; other site 316274015576 substrate-Mg2+ binding site; other site 316274015577 aspartate-rich region 1; other site 316274015578 aspartate-rich region 2; other site 316274015579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274015580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 316274015581 active site 316274015582 phosphorylation site [posttranslational modification] 316274015583 intermolecular recognition site; other site 316274015584 dimerization interface [polypeptide binding]; other site 316274015585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274015586 DNA binding residues [nucleotide binding] 316274015587 dimerization interface [polypeptide binding]; other site 316274015588 PHAX RNA-binding domain; Region: RNA_GG_bind; pfam10258 316274015589 WYL domain; Region: WYL; pfam13280 316274015590 Predicted transcriptional regulator [Transcription]; Region: COG2378 316274015591 WYL domain; Region: WYL; pfam13280 316274015592 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 316274015593 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 316274015594 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 316274015595 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 316274015596 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 316274015597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 316274015598 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 316274015599 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 316274015600 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 316274015601 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316274015602 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 316274015603 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 316274015604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274015605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274015606 DNA binding residues [nucleotide binding] 316274015607 dimerization interface [polypeptide binding]; other site 316274015608 Ornithine decarboxylase antizyme; Region: ODC_AZ; pfam02100 316274015609 NMT1/THI5 like; Region: NMT1; pfam09084 316274015610 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 316274015611 substrate binding pocket [chemical binding]; other site 316274015612 membrane-bound complex binding site; other site 316274015613 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 316274015614 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 316274015615 active site 316274015616 substrate binding site [chemical binding]; other site 316274015617 trimer interface [polypeptide binding]; other site 316274015618 CoA binding site [chemical binding]; other site 316274015619 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 316274015620 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 316274015621 active site 316274015622 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274015623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274015624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316274015625 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316274015626 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 316274015627 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 316274015628 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316274015629 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316274015630 Probable Catalytic site; other site 316274015631 metal-binding site 316274015632 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316274015633 Ligand binding site; other site 316274015634 Putative Catalytic site; other site 316274015635 DXD motif; other site 316274015636 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274015637 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274015638 putative trimer interface [polypeptide binding]; other site 316274015639 putative trimer interface [polypeptide binding]; other site 316274015640 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 316274015641 putative trimer interface [polypeptide binding]; other site 316274015642 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 316274015643 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015644 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015645 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015646 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015647 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015648 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015649 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015650 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 316274015651 WYL domain; Region: WYL; pfam13280 316274015652 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274015653 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274015654 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 316274015655 active site 316274015656 catalytic site [active] 316274015657 substrate binding site [chemical binding]; other site 316274015658 uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914 316274015659 putative active site [active] 316274015660 Domain of unknown function DUF87; Region: DUF87; pfam01935 316274015661 AAA-like domain; Region: AAA_10; pfam12846 316274015662 AAA-like domain; Region: AAA_10; pfam12846 316274015663 Domain of unknown function DUF87; Region: DUF87; pfam01935 316274015664 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 316274015665 Replication-relaxation; Region: Replic_Relax; pfam13814 316274015666 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316274015667 NlpC/P60 family; Region: NLPC_P60; pfam00877 316274015668 NACHT domain; Region: NACHT; pfam05729 316274015669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274015670 Walker A motif; other site 316274015671 ATP binding site [chemical binding]; other site 316274015672 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274015673 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274015674 NACHT domain; Region: NACHT; pfam05729 316274015675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 316274015676 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274015677 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274015678 NACHT domain; Region: NACHT; pfam05729 316274015679 RNA helicase; Region: RNA_helicase; pfam00910 316274015680 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274015681 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274015682 Caspase domain; Region: Peptidase_C14; pfam00656 316274015683 AAA ATPase domain; Region: AAA_16; pfam13191 316274015684 NACHT domain; Region: NACHT; pfam05729 316274015685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274015686 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274015687 MULE transposase domain; Region: MULE; pfam10551 316274015688 CHAT domain; Region: CHAT; pfam12770 316274015689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316274015690 Walker B motif; other site 316274015691 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316274015692 metal ion-dependent adhesion site (MIDAS); other site 316274015693 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 316274015694 active site 316274015695 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316274015696 active site 316274015697 ATP binding site [chemical binding]; other site 316274015698 substrate binding site [chemical binding]; other site 316274015699 activation loop (A-loop); other site 316274015700 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316274015701 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274015702 catalytic residues [active] 316274015703 catalytic nucleophile [active] 316274015704 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274015705 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274015706 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274015707 Synaptic Site I dimer interface [polypeptide binding]; other site 316274015708 DNA binding site [nucleotide binding] 316274015709 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015710 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015711 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015712 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015713 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015714 FG-GAP repeat; Region: FG-GAP_2; pfam14312 316274015715 CHAT domain; Region: CHAT; cl17868 316274015716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015717 binding surface 316274015718 TPR motif; other site 316274015719 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316274015720 RHS Repeat; Region: RHS_repeat; cl11982 316274015721 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316274015722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015723 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274015724 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274015725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015727 binding surface 316274015728 TPR motif; other site 316274015729 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015730 AAA ATPase domain; Region: AAA_16; pfam13191 316274015731 AAA ATPase domain; Region: AAA_16; pfam13191 316274015732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015733 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274015734 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015736 binding surface 316274015737 TPR motif; other site 316274015738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015740 binding surface 316274015741 TPR motif; other site 316274015742 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015743 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015745 binding surface 316274015746 TPR motif; other site 316274015747 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015750 binding surface 316274015751 TPR motif; other site 316274015752 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015754 binding surface 316274015755 TPR motif; other site 316274015756 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015757 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 316274015758 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274015759 putative active site [active] 316274015760 putative NTP binding site [chemical binding]; other site 316274015761 putative nucleic acid binding site [nucleotide binding]; other site 316274015762 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 316274015763 CHAT domain; Region: CHAT; cl17868 316274015764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015766 binding surface 316274015767 TPR motif; other site 316274015768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015771 binding surface 316274015772 TPR motif; other site 316274015773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015775 binding surface 316274015776 TPR motif; other site 316274015777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015780 TPR motif; other site 316274015781 binding surface 316274015782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274015784 binding surface 316274015785 TPR motif; other site 316274015786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015788 binding surface 316274015789 TPR motif; other site 316274015790 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015791 AAA ATPase domain; Region: AAA_16; pfam13191 316274015792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015794 binding surface 316274015795 TPR motif; other site 316274015796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015800 TPR motif; other site 316274015801 binding surface 316274015802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015803 NACHT domain; Region: NACHT; pfam05729 316274015804 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 316274015805 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316274015806 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316274015807 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316274015808 Putative transposase; Region: Y2_Tnp; pfam04986 316274015809 integron integrase; Region: integrase_gron; TIGR02249 316274015810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274015811 active site 316274015812 DNA binding site [nucleotide binding] 316274015813 Int/Topo IB signature motif; other site 316274015814 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 316274015815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274015816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316274015817 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274015818 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 316274015819 DNA binding site [nucleotide binding] 316274015820 Int/Topo IB signature motif; other site 316274015821 active site 316274015822 catalytic residues [active] 316274015823 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 316274015824 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316274015825 XisI protein; Region: XisI; pfam08869 316274015826 XisH protein; Region: XisH; pfam08814 316274015827 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316274015828 oligomeric interface; other site 316274015829 putative active site [active] 316274015830 homodimer interface [polypeptide binding]; other site 316274015831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274015832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274015833 non-specific DNA binding site [nucleotide binding]; other site 316274015834 salt bridge; other site 316274015835 sequence-specific DNA binding site [nucleotide binding]; other site 316274015836 AAA ATPase domain; Region: AAA_16; pfam13191 316274015837 Predicted ATPase [General function prediction only]; Region: COG3903 316274015838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274015840 binding surface 316274015841 TPR motif; other site 316274015842 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 316274015843 active site 316274015844 catalytic triad [active] 316274015845 Cupin domain; Region: Cupin_2; cl17218 316274015846 CCC1-related family of proteins; Region: CCC1_like; cl00278 316274015847 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 316274015848 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 316274015849 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316274015850 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 316274015851 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316274015852 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 316274015853 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 316274015854 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316274015855 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316274015856 catalytic residues [active] 316274015857 catalytic nucleophile [active] 316274015858 Presynaptic Site I dimer interface [polypeptide binding]; other site 316274015859 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316274015860 Synaptic Flat tetramer interface [polypeptide binding]; other site 316274015861 Synaptic Site I dimer interface [polypeptide binding]; other site 316274015862 DNA binding site [nucleotide binding] 316274015863 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 316274015864 DNA-binding interface [nucleotide binding]; DNA binding site 316274015865 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 316274015866 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274015867 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015868 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015869 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316274015870 amidase catalytic site [active] 316274015871 Zn binding residues [ion binding]; other site 316274015872 substrate binding site [chemical binding]; other site 316274015873 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015874 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274015875 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015876 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316274015877 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015878 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316274015879 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 316274015880 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274015881 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316274015882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274015883 active site 316274015884 phosphorylation site [posttranslational modification] 316274015885 intermolecular recognition site; other site 316274015886 dimerization interface [polypeptide binding]; other site 316274015887 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274015888 GAF domain; Region: GAF; pfam01590 316274015889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274015890 PAS fold; Region: PAS_3; pfam08447 316274015891 putative active site [active] 316274015892 heme pocket [chemical binding]; other site 316274015893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274015894 putative active site [active] 316274015895 PAS fold; Region: PAS_3; pfam08447 316274015896 heme pocket [chemical binding]; other site 316274015897 PAS domain; Region: PAS_9; pfam13426 316274015898 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 316274015899 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274015900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316274015901 active site 316274015902 phosphorylation site [posttranslational modification] 316274015903 intermolecular recognition site; other site 316274015904 dimerization interface [polypeptide binding]; other site 316274015905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274015906 DNA binding residues [nucleotide binding] 316274015907 dimerization interface [polypeptide binding]; other site 316274015908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316274015909 PAS domain; Region: PAS_9; pfam13426 316274015910 putative active site [active] 316274015911 heme pocket [chemical binding]; other site 316274015912 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316274015913 GAF domain; Region: GAF; pfam01590 316274015914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316274015915 Histidine kinase; Region: HisKA_3; pfam07730 316274015916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316274015917 ATP binding site [chemical binding]; other site 316274015918 Mg2+ binding site [ion binding]; other site 316274015919 G-X-G motif; other site 316274015920 NMT1/THI5 like; Region: NMT1; pfam09084 316274015921 short chain dehydrogenase; Provisional; Region: PRK06197 316274015922 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 316274015923 putative NAD(P) binding site [chemical binding]; other site 316274015924 active site 316274015925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316274015926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316274015927 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316274015928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 316274015929 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316274015930 AAA ATPase domain; Region: AAA_16; pfam13191 316274015931 NB-ARC domain; Region: NB-ARC; pfam00931 316274015932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274015934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316274015935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316274015936 active site 316274015937 AAA ATPase domain; Region: AAA_16; pfam13191 316274015938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 316274015939 Uncharacterized conserved protein [Function unknown]; Region: COG1479 316274015940 Protein of unknown function DUF262; Region: DUF262; pfam03235 316274015941 Uncharacterized conserved protein [Function unknown]; Region: COG3472 316274015942 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 316274015943 Family description; Region: UvrD_C_2; pfam13538 316274015944 AAA domain; Region: AAA_22; pfam13401 316274015945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316274015946 ATP binding site [chemical binding]; other site 316274015947 Walker A motif; other site 316274015948 Walker B motif; other site 316274015949 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316274015950 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316274015951 active site 316274015952 DNA binding site [nucleotide binding] 316274015953 Int/Topo IB signature motif; other site 316274015954 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 316274015955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316274015956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316274015957 DNA binding residues [nucleotide binding] 316274015958 Winged helix-turn helix; Region: HTH_29; pfam13551 316274015959 Homeodomain-like domain; Region: HTH_32; pfam13565 316274015960 Integrase core domain; Region: rve; pfam00665 316274015961 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 316274015962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316274015963 binding surface 316274015964 TPR motif; other site 316274015965 SWIM zinc finger; Region: SWIM; pfam04434 316274015966 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 316274015967 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 316274015968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274015969 ATP binding site [chemical binding]; other site 316274015970 putative Mg++ binding site [ion binding]; other site 316274015971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316274015972 nucleotide binding region [chemical binding]; other site 316274015973 ATP-binding site [chemical binding]; other site 316274015974 legume lectins; Region: lectin_L-type; cd01951 316274015975 homotetramer interaction site [polypeptide binding]; other site 316274015976 homodimer interaction site [polypeptide binding]; other site 316274015977 carbohydrate binding site [chemical binding]; other site 316274015978 metal binding site [ion binding]; metal-binding site 316274015979 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316274015980 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316274015981 structural tetrad; other site 316274015982 AAA domain; Region: AAA_33; pfam13671 316274015983 AAA domain; Region: AAA_17; pfam13207 316274015984 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274015985 Replication-relaxation; Region: Replic_Relax; pfam13814 316274015986 AAA-like domain; Region: AAA_10; pfam12846 316274015987 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 316274015988 AAA-like domain; Region: AAA_10; pfam12846 316274015989 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316274015990 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316274015991 putative active site [active] 316274015992 putative NTP binding site [chemical binding]; other site 316274015993 putative nucleic acid binding site [nucleotide binding]; other site 316274015994 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316274015995 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 316274015996 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316274015997 active site 316274015998 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274015999 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274016000 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274016001 BNR repeat-like domain; Region: BNR_2; pfam13088 316274016002 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316274016003 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316274016004 dimer interface [polypeptide binding]; other site 316274016005 ssDNA binding site [nucleotide binding]; other site 316274016006 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316274016007 Homeodomain-like domain; Region: HTH_23; pfam13384 316274016008 Winged helix-turn helix; Region: HTH_29; pfam13551 316274016009 Homeodomain-like domain; Region: HTH_32; pfam13565 316274016010 Integrase core domain; Region: rve; pfam00665 316274016011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 316274016012 Cytochrome P450; Region: p450; pfam00067 316274016013 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274016014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316274016015 active site 316274016016 Leucine rich repeat; Region: LRR_8; pfam13855 316274016017 Leucine rich repeat; Region: LRR_8; pfam13855 316274016018 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 316274016019 Leucine rich repeat; Region: LRR_8; pfam13855 316274016020 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 316274016021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 316274016022 Beta-Casp domain; Region: Beta-Casp; smart01027 316274016023 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 316274016024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016025 TPR motif; other site 316274016026 binding surface 316274016027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016029 binding surface 316274016030 TPR motif; other site 316274016031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016033 binding surface 316274016034 TPR motif; other site 316274016035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 316274016037 MULE transposase domain; Region: MULE; pfam10551 316274016038 AAA ATPase domain; Region: AAA_16; pfam13191 316274016039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016041 binding surface 316274016042 CHAT domain; Region: CHAT; cl17868 316274016043 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 316274016044 AAA ATPase domain; Region: AAA_16; pfam13191 316274016045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016048 binding surface 316274016049 TPR motif; other site 316274016050 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016051 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016053 binding surface 316274016054 TPR motif; other site 316274016055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016057 binding surface 316274016058 TPR motif; other site 316274016059 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016062 binding surface 316274016063 TPR motif; other site 316274016064 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016065 Ribosomally synthesized peptide in Herpetosiphon; Region: Herpeto_peptide; pfam14409 316274016066 HNH endonuclease; Region: HNH; pfam01844 316274016067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274016068 AAA domain; Region: AAA_23; pfam13476 316274016069 Walker A/P-loop; other site 316274016070 ATP binding site [chemical binding]; other site 316274016071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316274016072 AAA domain; Region: AAA_21; pfam13304 316274016073 ABC transporter signature motif; other site 316274016074 Walker B; other site 316274016075 D-loop; other site 316274016076 H-loop/switch region; other site 316274016077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316274016078 S-adenosylmethionine binding site [chemical binding]; other site 316274016079 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 316274016080 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316274016081 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316274016082 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 316274016083 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316274016084 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 316274016085 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 316274016086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316274016087 ATP binding site [chemical binding]; other site 316274016088 putative Mg++ binding site [ion binding]; other site 316274016089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 316274016090 nucleotide binding region [chemical binding]; other site 316274016091 ATP-binding site [chemical binding]; other site 316274016092 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316274016093 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 316274016094 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 316274016095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016098 binding surface 316274016099 TPR motif; other site 316274016100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016101 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016102 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016103 Tetratricopeptide repeat; Region: TPR_10; pfam13374 316274016104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316274016106 binding surface 316274016107 TPR motif; other site 316274016108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316274016109 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316274016110 Peptidase family M23; Region: Peptidase_M23; pfam01551 316274016111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316274016112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316274016113 non-specific DNA binding site [nucleotide binding]; other site 316274016114 salt bridge; other site 316274016115 sequence-specific DNA binding site [nucleotide binding]; other site 316274016116 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316274016117 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316274016118 nucleotide binding site [chemical binding]; other site 316274016119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697